Pure Insight Executive Membership - Best Practice Visit Outline Company AstraZeneca Topic(s) R&D Portfolio Management & Business Performance Management (specific focus on Development rather than Discovery) Date and Location November 11, 2008 Alderley Park, Macclesfield, Cheshire Visit leader Speaker 1: Dr Mellor Hennessy (Global Portfolio Strategist) Speaker 2: David Scanlon (Business Manager) Company/ Presentation background Mellor Hennessy was part of the Portfolio integration task force when Astra and Zeneca merged in 1999. Since then he has been a member of the cross functional team running the Portfolio process and making incremental improvements at each annual review. Recently he has taken on leadership of the R&D Performance Network – cascading the R&D scorecard throughout the organisation. His professional interest is innovation in management practice. AstraZeneca is a global Pharmaceutical company with an R&D organisation of 13,000 people and annual budget of $3-4B. A stage/gate process is at the heart of Pharmaceutical R&D and the Development organisation at AstraZeneca is currently focused on establishing a project management and continuous improvement culture. Performance metrics throughout R&D are pipeline progressions, time, unit cost, and value. Mellor and David will describe the evolution of both Portfolio Management and Business Performance Management at AstraZeneca, explaining what innovations in practice have worked well and why. They will also share learning from some of the failures, and describe future ambitions. As well as the presentations, the visit will include: Recommended for 30 minute tour of Alderley Park Country Estate 60 minutes of Q&A: An opportunity to dig deeper with the AstraZeneca team 45 minutes of Roundtable Discussions: Addressing participants’ most pressing challenges 90 minutes Open Networking sessions: Meet and develop relationships with other Executive and Group members Anyone interested in understanding what generates significant and lasting change in an organisation; how to manage product portfolios and business performance in large and complex environments; and what works and what doesn’t when integrating, teams, processes and companies. Draft itinerary 10.00 – 10.15 Introductions and welcome 10.15 – 10.30 Mellor Hennessy - Pharma, R&D and AstraZeneca The pharma stage/gate process Industry and AstraZeneca dimensions The merger of Astra and Zeneca, and evolution to date 10.30 – 11.15 Mellor Hennessy - R&D Business Performance Management Cascade of objectives to 12,000 people in R&D Managing performance of 20 organisation units within R&D Using performance management process to drive portfolio objectives Factors determining success over past 10 years Does it really work? 11.15 – 11.45 Coffee, networking break 11.45 – 12.30 David Scanlon - Project and Portfolio Management Merging Astra & Zeneca to create one portfolio & one process Evolving the portfolio process over the past decade - what has changed and why Integrating project and portfolio management The future - integrated systems and behaviour change - will it work? 12.30 – 13.30 Networking lunch 13.30 – 14.00 Q&A session with AstraZeneca team 14.00 – 14.30 Tour of Alderley Park Country Estate 14.30 – 15.15 Roundtable discussions Additional information For those arriving the night before the visit, The Alderley Edge hotel is situated 10 minutes drive from the AstraZeneca site (www.alderleyedgehotel.com)