Erik M. Shapiro, PhD
Departments of Diagnostic Radiology and Biomedical Engineering
Yale University School of Medicine
300 Cedar Street, TAC N129
New Haven, CT 06510
Phone: (203) 785-2899; Fax (203) 785-6643; Email: erik.shapiro@yale.edu
PROFESSIONAL EXPERIENCE
Department of Biomedical Engineering
Yale University
Assistant Professor, September 2007Department of Diagnostic Radiology
Yale University School of Medicine
Assistant Professor, May 2006Department of Radiology and The Helen and Martin Kimmel Center for Stem Cell Biology,
New York University School of Medicine
Assistant Professor, January 2005-April 2006
EDUCATION
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Post-doctoral Fellow, Laboratory of Functional and Molecular Imaging, November 2001 - December 2004
Mentor: Dr. Alan P. Koretsky
Fellowship: "Molecular and Cellular Imaging"
University of Pennsylvania, Philadelphia, PA
Ph.D. in Chemistry, May 2001
Thesis advisor: Dr. John S. Leigh (Radiology)
Thesis title: "Multi-nuclear Magnetic Resonance Methods for Evaluating Cartilage Degeneration"
University of Pennsylvania, Philadelphia, PA
M.S. in Chemistry, December 1997
Thesis advisor: Dr. Stanley J. Opella
Thesis title: "Isolation and Solid-State NMR Studies of merT, a Bacterial Membrane Protein"
State University of New York at Binghamton, Binghamton, NY
B.S. in Chemistry, 1991-1995
PUBLICATIONS
32. Nelson, G.N., Roh, J.D., Mirensky, T.L., Wang, Y., Yi, T., Tellides, G., Pober, J.S., Shkarin, O., Shapiro,
E.M., Saltzman, W.M., Papademetris, X., Fhamy, T.M., Breuer, C.K., Initial evaluation of the use of USPIO cell
labelling and non-invasive MR monitoring of human tissue-engineered vascular grafts in vivo, FASEB J., in press
(2008).
31. Sumner, J.P., Shapiro, E.M., Maric, D., Conroy, R., Koretsky, A.P., In vivo labelling of adult neural
progenitors for MRI with micron sized particles of iron oxide: Quantitation of labelled phenotype, NeuroImage,
in press (2008).
30. Shapiro, E.M., Koretsky, A.P., Convertible manganese contrast for molecular and cellular imaging, Magnetic
Resonance in Medicine, 60(2), 265-269 (2008).
29. Bennett, K.M., Shapiro, E.M., Sotak, C.H., Koretsky, A.P., Controlled aggregation of ferritin to modulate
MRI relaxivity, Biophysical Journal, 95(1), 342-351 (2008).
28. Sumner, J.P., Conroy, R., Shapiro, E.M., Moreland, J., Koretsky, A.P., Delivery of fluorescent probes using
iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance
imaging and optical imaging, Journal of Biomedical Optics, 12(5) (2007).
27. Slotkin, J.R., Cahill, K.S., Tharin, S.A., Shapiro, E.M., Cellular Magnetic Resonance Imaging: Nanometer
and Micrometer Size Particles for Noninvasive Cell Localization, Neurotherapeutics, 4(3), 428-433 (2007).
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26. Shapiro, E.M., Medford-Davis, L.N., Fahmy, T., Dunbar, C.E., Koretsky, A.P., Antibody-mediated cell
labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI,
Contrast Media and Molecular Imaging, 2(3), 147-153 (2007).
25. Shapiro, E.M., Gonzalez-Perez, O., Garcia-Verdugo, J.M., Alvarez-Buylla, A., Koretsky, A.P., Magnetic
resonance imaging of the migration of neuronal precursors generated in the adult rodent brain, NeuroImage,
32(3), 1150-1157 (2006).
24. Rodriguez, O., Fricke, S., Chien, C., Dettin, L., VanMeter, J., Shapiro, E.M., Dai., H., Casimiro, M., Ileva,
L., Dagata, J., Johnson, M., Koretsky, A.P., Albanese, C., Contrast-enhanced in vivo imaging of breast and
prostate cancer cells by MRI, Cell Cycle, 5(1), 113-119 (2006).
23. Shapiro, E.M., Sharer, K., Skrtic, S., Koretsky, A.P., In vivo detection of single cells by MRI, Magnetic
Resonance in Medicine, 55, 242-249 (2006).
22. Himmelreich, U., Weber, R., Ramos-Cabrer, P., Wegener, S., Kandal, K., Shapiro, E.M., Koretsky, A.P.,
Hoehn, M., Improved stem cell MR detectability in animal models by modification of the inhalation gas,
Molecular Imaging, 4(2), 104-109 (2005).
21. Shapiro, E.M., Skrtic, S., Koretsky, A.P., Sizing it up: Cellular MRI using micron sized iron oxide particles,
Magnetic Resonance in Medicine, 53, 329-338 (2005).
20. Gougoutas, A.J., Wheaton, A.J., Borthakur, A., Shapiro, E.M., Kneeland, J.B., Udupa, J.K., Reddy, R.,
Cartilage volume quantification via Live Wire segmentation, Academic Radiology, 11(12), 1389-1395 (2004).
19. Shapiro, E.M., Skrtic, S., Sharer, K., Hill, J.M., Dunbar, C.E., Koretsky, A.P., MRI detection of single
particles for molecular and cellular imaging, Proceedings of the National Academy of Sciences, 191(30), 1090110906 (2004).
18. Wheaton, A.J., Borthakur, A., Shapiro, E.M., Regatte, R.R., Akella, S.V.S., Kneeland, J.B., Reddy, R.,
Proteoglycan loss in human knee cartilage: Quantitation with sodium MR imaging – Feasibility Study, Radiology,
231, 900-905 (2004).
17. Hinds, K.A., Hill, J.M., Shapiro, E.M., Silva, A.C., Varney, T.R., Combs, C.A., Balaban, R.S., Koretsky,
A.P., Dunbar, C.E., Highly efficient endosomal labelling of progenitor and stem cells with large magnetic
particles allows magnetic resonance imaging of single cells, Blood, 102(3), 867-872 (2003).
16. Borthakur, A., Wheaton, A., Charagundla, S.R., Shapiro, E.M., Regatte, R.R., Akella, S.V.S., Kneeland, J.B.,
Reddy, R., 3D T1-weighted MRI at 1.5 Tesla, Journal of Magnetic Resonance Imaging, 17, 730-736 (2003).
15. Aoki, I., Ebisu, T., Tanaka, C., Katsuta, K., Fujikawa, A., Umeda, M., Fukunaga, M., Takegami, T., Shapiro,
E.M., Naruse, S., Detection of the anoxic depolarization of focal ischemia using manganese enhanced MRI,
Magnetic Resonance in Medicine, 48, 927-933 (2002).
14. Borthakur, A., Shapiro, E.M., Akella, S.V.S., Gougoutas, A., Kneeland, J.B., Reddy, R., Quantifying sodium
in the human wrist in vivo using MRI, Radiology, 224, 598-602 (2002).
13. Shapiro, E.M., Borthakur, A., Shapiro, M.J., Reddy, R., and Leigh, J.S., Fast MR imaging of RF heating via
phase difference mapping, Magnetic Resonance in Medicine, 47, 492-498 (2002).
12. Shapiro, E.M., Borthakur, A., Gougoutas, A. and Reddy, R., 23Na MRI accurately measures fixed charge
density in articular cartilage, Magnetic Resonance in Medicine, 47, 284-291 (2002).
11. Borthakur, A., Shapiro, E.M., Beers, J., Kudchodkar, S., Kneeland, J.B.and Reddy, R., Effect of IL-1
induced macromolecular depletion on residual quadrupolar interaction in articular cartilage, Journal of Magnetic
Resonance Imaging, 15(3), 315-323 (2002).
10. Sydow B.D., Gougoutas A.J., Shapiro E.M., Lonner J., Khurana J., Schumacher H.R., Kneeland J.B., Reddy
R., Osteoarthritis: In vitro correlation of sodium MRI with histologic findings in human osteoarthritic cartilage,
Arthritis and Rheumatism 44(9), 515 (2001).
9. Shapiro, E.M., Borthakur, A., Kaufman, J., Leigh, J.S., and Reddy, R., Water distribution patterns inside
bovine articular cartilage as visualized by 1H magnetic resonance imaging, Osteoarthritis and Cartilage, 9(6),
533-538 (2001).
8. Li, L., Shapiro, E.M. and Leigh, J.S. Significant precision improvement for temperature mapping, Magnetic
Resonance in Medicine, 46, 678-682 (2001).
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7. Akella, S.V.S., Regatte, R.R., Gougoutas, A.J., Borthakur, A., Shapiro, E.M., Kneeland, J.B., Leigh, J.S. and
Reddy, R., Proteoglycan induced changes in T1-relaxation of articular cartilage at 4T, Magnetic Resonance in
Medicine, 46,419-423 (2001).
6. Shapiro, E.M., Borthakur, A., and Reddy, R., MR imaging of RF heating using a paramagnetic doped agarose
phantom, MAGMA 10(2), 114-121 (2000).
5. Borthakur, A., Shapiro, E.M., Beers, J., Kudchodkar, S., and Reddy, R., Sensitivity of MRI to proteoglycan
depletion in cartilage: Comparison of sodium and proton MRI, Osteoarthritis and Cartilage 8(4), 288-293 (2000).
4. Shapiro, E.M., Borthakur, A., Reddy, R.R., Bansal, N, Leigh, J.S., and Reddy, R., Temperature dependent
chemical shift and relaxation times of 23Na in Na4HTm[DOTP], Journal of Magnetic Resonance 143, 213-216
(2000).
3. Shapiro, E.M., Borthakur, A., Dandora, R., Kriss, A., Leigh, J.S., and Reddy, R., Sodium visibility and
quantitation in intact bovine articular cartilage using high field 23Na MRI and MRS, Journal of Magnetic
Resonance 142, 24-31 (2000).
2. Borthakur, A., Hancu I., Boada, F.E., Shen, G.X., Shapiro, E.M., and Reddy, R., In vivo triple quantum
filtered twisted projection sodium MRI of human articular cartilage, Journal of Magnetic Resonance 141, 286290 (1999).
1. Reddy, R., Borthakur, A., Shapiro, E.M., Duvvuri, U., Schumacher, R., and Kneeland, J.B., Sensitivity of
proton and sodium MRI in quantitating proteoglycan distribution in cartilage, Arthritis and Rheumatism 42(9),
454 (1999).
Book Chapters
Shapiro, E.M., Koretsky, A.P., “Micron-Sized Iron Oxide particles (MPIOs) for Cellular Imaging: More Bang
for the Buck”, in Nanoparticles in Biomedical Imaging: Emerging Technologies and Applications (Fundamental
Biomedical Technologies Series), Springer Media, eds. Jeff W.M. Bulte and Michel M.J. Modo, 2008.
HONORS, FELLOWSHIPS, SOCIETIES AND PATENTS
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Yale University Medical School Clinical and Translational Science Award, 2007
Kingsley Fellowship in Medical Research, 2006-2008
Young Investigator’s Award Finalist, International Society of Magnetic Resonance in Medicine, 2005
NIH Fellows Award for Research Excellence, 2004
Finalist, Wharton Business Plan Competition, 2001
Young Investigator’s Award Winner, Osteoarthritis Research Society International, 2000
Phi Lambda Upsilon Chemistry Honor Society, President, 1996-1997.
Graduate Fellowship in Structural and Molecular Genetic Studies, Plant Science Institute, University of
Pennsylvania, 1995-1998.
Sandoz Pharmaceuticals Summer Internship Program, 1991-1995.
Member, International Society of Magnetic Resonance in Medicine.
Member, Society for Molecular Imaging
Member, New York Academy of Sciences
United States Patent # 6,836,114 - Pulse Imaging Sequences and Methods for T1ρ-Weighted MRI.
INVITED LECTURES and COURSES
2005
University of Maryland School of Pharmaceutical Science, PHAR 639: Molecular Spectroscopy and Imaging,
“Introduction to Molecular Imaging”
New York Academy of Sciences, Of Molecules and Magnets: Designer Contrast Agents for Better Looking MRI,
“Sizing Up Cellular Magnetic Resonance Imaging”
2006
International Society for Magnetic Resonance in Medicine 14th Annual Symposium, Seattle, WA, New Horizons
in Musculoskeletal MRI Categorical Course, “MRI Techniques for Stem Cell Trafficking”, Graded 1.5 on NIH 5
point scale.
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Third Spring School on Regenerative Medicine, University of Rostock, Germany, “In Vivo Detection of Single
Cells by MRI”
International Brain Mapping and Intraoperative Surgical Planning Society Third Annual Congress, ClermontFerrand, France, “Magnetic Resonance Imaging of Neural Progenitor Cell Migration”
**Session chair, “Cellular and Molecular MRI”
National Institute of Radiological Sciences, Chiba, Japan, “Use of Iron Oxide Microspheres for Molecular and
Cellular MRI”
Japanese Society of Magnetic Resonance in Medicine 34th Scientific Meeting, Tsukuba, Japan, “Sizing Up
Cellular MRI”
Yale University, Department of Bioengineering, BENG 351: Quantitative Physiology, “Molecular and Cellular
Imaging by MRI”
The Clore Workshop on Novel Imaging Technologies in Disease Models, Weizmann Institute, Israel, “More Bang
for the Buck: Cellular MRI with Micron-Sized Particles”
University of Maryland School of Pharmaceutical Science, PHAR 639: Molecular Spectroscopy and Imaging,
“Introduction to Molecular Imaging”
2007
International Society for Magnetic Resonance in Medicine Workshop: Cruising into Molecular and Cellular
Imaging, Galveston, TX, “Sizing Up Cellular MRI with Micron Sized Iron Oxide Particles (MPIOs)”
**Session chair - “The bright future of MEMRI”
Penn State College of Medicine, Hershey, PA, Neuroscience Research Institute Seminar Series, “Sizing up
Cellular MRI: Towards in vivo Single Cell Imaging”
Yale Institute of Nanoscience and Quantum Engineering Seminar Series, “Sizing up Cellular MRI: Towards in
vivo Single Cell Imaging”
Yale University, Department of Bioengineering, BENG 351: Quantitative Physiology, “Molecular and Cellular
Imaging of the Immune System”
Yale University, Department of Bioengineering, BENG 421: Physics of Medical Imaging, “Molecular and
Cellular Imaging by MRI”
Johns Hopkins School of Medicine, Institute for Cellular Engineering Seminar Series, “Sizing up Cellular MRI:
Towards in vivo Single Cell Imaging”
Yale University, 1st Annual Molecular and Cellular Magnetic Resonance Imaging Symposium, “Cellular Imaging
by MRI”
International Society for Magnetic Resonance 16th Triennial Conference, Kenting, Taiwan, “Sizing up Single Cell
Imaging by MRI”
**Session chair - “MRI”
Cambridge Healthtech Institute 4th Annual In Vitro Molecular Imaging Symposium, San Diego, CA, “Sizing Up
Cellular MRI with Micron Sized Iron Oxide Particles”
2008
Brown University, Department of Chemistry Inorganic/Materials Science Seminar Series, “Magnetic
nanoparticles and MRI”
Yale University, Symposium on Quantitative Neuroscience with Magnetic Resonance, “Cellular Imaging by
MRI”
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