Libo Cao
CONTACT INFORMATION
Metara, Inc., 1225 East Arques, Sunnyvalue, CA 94085, USA. Tel: (408) -331-5248 (office), (408)-429-0892 (cell)
Email: libocao@gmail.com
SUMMARY
 Over seven years experience in analytical method development, three years in Chemometrics and intelligent
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instrumentation.
Hands-on experience with chemical instruments: HPLC, GC, MS, IMS, NIR, TLC, FTIR, CE and UV-Vis.
Six years experience in method development and data processing for GC-MS and IMS data.
Expert in Chemometrics algorithm and GUI design with MATLAB, C, C++, and LabVIEW.
Excellent computer skills. Experience in operating systems, software design and development, and database systems.
Quick learner and effective problem solver with leadership experience.
Strong communication skills. Proficiency in English and Chinese.
EDUCATION
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Ph.D. in Analytical Chemistry, Ohio University, 2000-2004.
M.S. of Mathematics in Computer Science Option, Ohio University, 2000-2003.
M.S. candidate in Applied Chemistry, Dalian University of Technology, 1998-2000.
B.S. of Engineering in Applied Chemistry, Dalian University of Technology, 1995-1998.
RELATED EXPERIENCE
Metara Inc., Chemometrics Software Scientist
04/04 ~ present
 Developed Data Analysis Engine Patent for automated mass spectrometer in semiconductor industry.
 Design and develop complex data reduction algorithms for spectral peak identification, baseline and background
subtraction, de-convolution and quantization. Develop high quality, low defect data analysis software for chemical
instrument with user friendly GUI and complex mathematical peak processing algorithms.
 Expertise on mechanism, operation and diagnose of automated MS used in semiconductor manufacture industry.
 Demonstrate created and analytical problem solving skills in Microsoft Windows/Unix Platform including C++, MFC,
ATL, COM, DCOM and SQL using MS SQL Server
 OOA/OOD software design and development methods, excellent written and verbal communication skills.
Center for Intelligent Chemical Instrumentation at Ohio University, Athens, OH
9/00~ 04/04
Research Assistant/Teaching Assistant
 Doctoral dissertation: Nonlinear wavelet compression methods for ion analyses and dynamic modeling of complex
systems.
 Developed MATLAB GUI software for dynamic equation modeling and data fitting for GC-MS and IMS data.
 Designed novel multivariate curve resolution methods for rapid detection of chemical warfare agents.
 Formulated two-dimensional nonlinear wavelet algorithm for data compression on IMS data.
 Supervised undergraduate general chemistry lab.
Department of Mathematics at Ohio University, Athens, OH
Research Assistant/Teaching Assistant
 Developed map/direction search software package.
 Designed genealogy tree answering software combined with a database system.
 Taught undergraduate basic mathematics courses.
9/01~12/03
Department of Chemistry, Dalian University of Technology, Dalian, China
7/97- 7/00
Research Associate
 Synthesized the intermediate for a new near-infrared absorbing dye used in enzyme immunoassay.
 Expertise with GC/MS, NIR, IR, UV, and HPLC at PRC national state key lab of DUT.
 Study on the systems for the analysis of DNA by capillary electrophoresis with laser induced fluorescence.
 Developed validation methods for a new-developed medicine.
COMPUTER SKILLS
 Proficient in programming languages: MATLAB, C, C++, HTML, COM, DCOM, SQL, and LabVIEW.
 Microsoft Certified Professional + Internet, Microsoft Certificated Software Engineer (MCSE).
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Libo Cao
SELECTED PUBLICATIONS AND PATENT
1) Gresham, G. L.; Gianotto, A. K.; Harrington, P. B.; Cao, L.; Scott, J. R.; Olson, J. E.; Appelhans, A. D.; Stipdonk, M.
J.; Groenewold, G. S. Gas-Phase hydration of U(IV), U(V), and U(VI) dioxo monocations. J. Phys. Chem. A 2003,
107, 8530-8538.
2) Cao, L.; Harrington, P. B.; Harden, C. S.; McHugh, V. M.; Thomas, M. A. Nonlinear wavelet compression of ion
mobility spectra from ion mobility spectrometers mounted in an unmanned aerial vehicle. Anal. Chem. 2004, 76,
1069-1077.
3) Cao, L.; Harrington, P. B.; Liu, C. Two-dimensional nonlinear wavelet compression (NLWC) of ion mobility spectra
of chemical warfare agent simulants. Anal. Chem., 2004, 76, 2859-2868.
4) Cao, L.; Harrington, P. B. ALS to modeling of ion mobility spectra. International Conference on Ion Mobility
Spectrometry; Cambridge, 2003.
5) Cao, L.; Harrington, P. B.; Liu, J. SIMPLISMA and ALS applied to two-dimensional nonlinear wavelet compressed
ion mobility spectra of chemical warfare agent simulants. Anal. Chem., 2005, 77, 2575-2586.
6) Cao, L.; Janko, C.; Chen, G. Mass Spectrometer Data Analysis Engine. U.S. Provisional Patent Application No.
60/711,083, filed August 23, 2005.
7) Cao, L. Auto-recognition of Chemical Components in Chemical Spectrum. U.S. Patent Application No. (in process).
SELECTED CONFERENCE PRESENTATIONS
1)
P.B. Harrington and Libo Cao, “Modeling Nonlinear Wavelet Compressed Ion Mobility Spectrometry”, presented at
the 12th International Conference on Ion Mobility Spectrometry, Umeå, Sweden, July 28, 2003.
2)
P.B. Harrington and Libo Cao, “Tutorial on Modeling and Wavelet Compression for Ion Mobility Spectrometrists”,
presented at the 12th International Conference on Ion Mobility Spectrometry, Umeå, Sweden, July 28, 2003.
3)
L. Cao, P.B. Harrington, and G. Chen, “Wavelet Compressed Mass Spectral Profiles Perform as Better Alternative to
Histogram Mass Spectra” presented at The 54th Pittsburgh Conference and Exposition on Analytical Chemistry &
Applied Spectroscopy, Orlando, FL, March 12, 2003, 1770-8P.
4)
L. Cao, P.B. Harrington, and G. Chen, “Wavelet Compressed Mass Spectral Profiles Perform as Better Alternative to
Histogram Mass Spectra” presented at The 54th Pittsburgh Conference and Exposition on Analytical Chemistry &
Applied Spectroscopy, Orlando, FL , March 10, 2003, 730-1.
5)
L. Cao, G. Chen, and P.B. Harrington, “Histogram Mass Spectra Lose Key Chemical Information: Are Wavelet
Compressed Mass Spectral Profiles a Viable Alternative?” presented at The 1st Ohio Analytical Chemistry
Consortium, Columbus, OH, November 8, 2002.
6)
L. Cao, G. Chen, and P.B. Harrington, “Histogram Mass Spectra Lose Key Chemical Information: Are Wavelet
Compressed Mass Spectral Profiles a Viable Alternative?”, The 50th ASMS Conference on Mass Spectrometry and
Applied Topics, Orlando, FL, June 3, 2002, MPK349.
PROFESSIONAL AFFILIATIONS
 Member, Sigma Xi, Scientific Research Society.
 Member, American Chemical Society.
 Member, International Chemometrics Society.
KEYWORDS
Chemometrics, Computational Chemistry, Analytical Chemistry, Method Development, LabVIEW, MATLAB, and C/C++.
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