DEPARTMENT OF NEUROSURGERY Peer Reviewed Journal Articles: 2010 DR. DRAKE 2010 Kulkarni AV, Warf BC, Drake JM, Mallucci CL, Sgouros S, Constantini S; Canadian Pediatric Neurosurgery Study Group. Surgery for hydrocephalus in sub-Saharan Africa versus developed nations: a risk-adjusted comparison of outcome. Childs Nerv Syst. 2010 Dec;26(12):1711-7. Coauthor or Collaborator. Kulkarni AV, Drake JM, Kestle JR, Mallucci CL, Sgouros S, Constantini S; Canadian Pediatric Neurosurgery Study Group. Endoscopic third ventriculostomy vs cerebrospinal fluid shunt in the treatment of hydrocephalus in children: a propensity score-adjusted analysis. Neurosurgery. 67(3):588-93. Senior Responsible Author. Drake JM. Shunt Failure. J Neurosurg Pediatr. 2010 Oct 6(4):316-7. Principal Author. Kukarni AV, Drake JM, Kestle JR, Mallucci CL, Sgouros S, Constantini S; Canadian Pediatric Neurosurgery Study Group. Predicting who will benefit from endoscopic third ventriculostomy compared with shunt insertion in childhood hydrocephalus using the ETV Success Score. J Neurosurg Pediatr. 2010 Oct;6(4):310-5. Senior Responsible Author. Drake JM, Riva-Cambrin J, Jea A, Auguste K, Tamber M, Lamberti-Pasculli M. Prospective surveillance of complications in a pediatric neurosurgery unit. J Neurosurg Pediatr. 2010 Jun; 5(6):544-8. Senior Responsible Author. King JA, Auguste KI, Halliday W, Drake JM, Kulkarni AV. Ventrculocystostomy and endoscopic third ventriculostomy/shunt placement in the management of hydrocephalus secondary to giant retrocerebellar cysts in infancy. J Neurosurg Pediatr. 2010 Apr;5(4): 403-7. Coauthor or Collaborator. Drake J, Zeller R, Kulkarni AV, Strantzas S, Holmes L. Intraoperative neurphysiological monitoring during complex spinal deformity cases in pediatric patients: methodolgy, utility, prognostication, and outcome. Childs Nerv Syst. 2010 Apr;26(4):523-44. Senior Responsible Author. Van de Beek D, Drake JM, Tunkel A. Nosocomial bacterial meningitis. New England Journal of Medicine. 2010, Apr 8;362(14). Coauthor or Collaborator. Burn SC, Zeller R, Drake JM. Do baclofen pumps influence the development of scoliosis in children? J Neurosurg Pediatr. Vol 5(2):195-9. Principal Author Ng WH, Drake JM. Symptomatic spinal epidural CSF collection after lumbar puncture in a young adult: case report and review of literature. Child‘s Nervous System: 2010: 26(2): pp 259-62. Principal Author. Low D, Seow WT, Ng WH, Drake J:. Management of ventriculo-peritoneal shunts in the paediatric population. Asian Journal of Neurosurgery. 2010 Jan;5(1):7-14. Coauthor or Collaborator. DR. DIRKS 2010 Scheinemann K, Bartels U, Tsangaris E, Hawkins C, Huang A, Dirks P, Fried I, Bouffet E, Tabori U. Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas. Pediatr Blood Cancer. 2010 Dec 1. Coauthor or Collaborator. Beier AD, Cheshier SH, Chakraborty A, Dirks P. Suprasellar arachnoid cyst resulting in the syndrome of inappropriate antidiuretic hormone secretion. J Neurosurg Pediatr. 2010 Nov;6(5):486-8. Senior Responsible Author. Ellis MJ, Kulkarni AV, Drake JM, Rutka JT, Armstrong D, Dirks PB. Intraoperative angiography during microsurgical removal of arteriovenous malformations in children. J Neurosurg Pediatr. 2010 Nov;6(5):435-43. Senior Responsible Author. Dirks PB. Brain tumor stem cells: the cancer stem cell hypothesis writ large. Mol Oncol. 2010 Oct;4(5):420-30. Epub 2010 Aug 10. Review. Principal Author. Mondal S, Dirks P, Rutka JT. Immunolocalization of Fascin, an Actin Bundling Protein and Glial Fibrillary Acidic Protein in Human Astrocytoma Cells. Brain Pathol 2010: 20: pp 190-199. C. Co-Principal Author. Peter Dirks. Cancer Stem Cells: Invitation to a Second Round. Nature: Vol 466.40-41. Principal Author. King JA, Armstrong D, Vachhrajani S, Dirks PB. Relative contributions of the middle meningeal artery and superficial temporal artery in revascularization surgery for moyamoya syndrome in children: the results of superselective angiography. Journal of Neurosurgery (Pediatrics) 2010: 5: pp 184-9. SRI. Senior Responsible Author DR. KULKARNI 2010 Kulkarni A.V., Warf B.C., Drake J.M., Mallucci C.L., Sgouros S., Constantini S. Surgery for hydrocephalus in sub‐Saharan Africa versus developed nations: A risk‐adjusted comparison of outcome 2010 Child's Nervous System Vol 26 pg. 17111717. Ellis M.J., Kulkarni A.V., Drake J.M., Rutka J.T., Armstrong D., Dirks P.B. Intraoperative angiography during microsurgical removal of arteriovenous malformations in children: Clinical article 2010 Journal of Neurosurgery:Pediatrics Vol 6 pg. 435-443. Fulkerson D.H., Vachhrajani S., Brayton A., Kulkarni A.V., Jea A. The perception of complications in pediatric spine surgery: A comparative survey of surgeons, caregivers and patients 2010 Pediatric Neurosurgery Vol 46 pg. 213-220. Kulkarni A.V., Shams I., Cochrane D.D., McNeely P.D. Does treatment with endoscopic third ventriculostomy result in less concern among parents of children with hydrocephalus? 2010 Child's Nervous System Vol 26 pg.1529-1534. O'Kelly C.J., Kulkarni A.V., Austin P.C., Wallace C., Urbach D. The impact of therapeutic modality on outcomes following repair of ruptured intracranial aneurysms: An administrative data analysis: Clinical article 2010 Journal of Neurosurgery Vol 113 pg. 795-801. Kulkarni A.V., Drake J.M., Kestle J.R.W., Mallucci C.L., Sgouros S., Constantini S., Hader W., Hamilton M., Cochrane D.D., Steinbok P., Vassilyadi M., Ventureyra E., Dirks P.B., Rutka J.T., Van Der Stoel A., Veltman I., Howes W., McNeely P.D., Walling S.A., Ranger A., Atkinson J., Farmer J.P., Montes J., Aronyk K., Mehta V., McDonald P.J. Predicting who will benefit from endoscopic third ventriculostomy compared with shunt insertion in childhood hydrocephalus using the ETV success score: Clinical article 2010 Journal of Neurosurgery: Pediatrics Vol 6 pg. 310-315. Kulkarni A.V., Drake J.M., Kestle J.R.W., Mallucci C.L., Sgouros S., Constantini S. Response 2010 Journal of Neurosurgery: Pediatrics Vol 6 pg. 309. Kulkarni A.V., Drake J.M., Kestle J.R.W., Mallucci C.L., Sgouros S., Constantini S. Endoscopic third ventriculostomy vs cerebrospinal fluid shunt in the treatment of hydrocephalus in children: A propensity score‐adjusted analysis 2010 Neurosurgery Vol 67 pg. 588-593. Ronghe M., Hargrave D., Bartels U., Tabori U., Vaidya S., Chandler C., Kulkarni A., Bouffet E. Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low‐grade astrocytoma of the brainstem 2010 Pediatric Blood and Cancer Vol 55 pg. 471 -477. Simon T.D., Hall M., Dean J.M., Kestle J.R.W., Riva‐Cambrin J., Walker M., Bach T., Langley M., Yearley J., Holubkov R., Kulkarni A., Drake J.M., O'Connor L., Oakes J., Wellons J., Shannon C., Whitehead W., Luerssen T., Ryan S.N., Browd S., Anderson A. Reinfection following initial cerebrospinal fluid shunt infection: Clinical article 2010 Journal of Neurosurgery: Pediatrics Vol 6 pg. 277-285. Kulkarni A.V., Shams I., Cochrane D.D., McNeely P.D. Quality of life after endoscopic third ventriculostomy and cerebrospinal fluid shunting: An adjusted multivariable analysis in a large cohort ‐ Clinical article 2010 Journal of Neurosurgery: PediatricsVol 6 pg. 11—16. Lafay‐Cousin L., Mabbott D.J., Halliday W., Taylor M.D., Tabori U., Kamaly‐Asl I.D., Kulkarni A.V., Bartels U., Greenberg M., Bouffet E. Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma 2010 Journal of Neurosurgery: Pediatrics Vol 5 pg. 615-621. Kulkarni A.V. Quality of life in childhood hydrocephalus: A review 2010 Child's Nervous System Vol 26 pg. 737-743. McDonald P.J., Kulkarni A.V., Farrokhyar F., Bhandari M. Ethical issues in surgical research 2010 Canadian Journal of Surgery Vol 53 pg. 133-136. King J.A.J., Auguste K.I., Halliday W., Drake J.M., Kulkarni A.V. Ventriculocystostomy and endoscopic third ventriculostomy/shunt placement in the management of hydrocephalus secondary to giant retrocerebellar cysts in infancy: Report of 3 cases 2010 Journal of Neurosurgery: Pediatrics Vol 5 pg. 403-407. Drake J., Zeller R., Kulkarni A.V., Strantzas S., Holmes L. Intraoperative neurophysiological monitoring during complex spinal deformity cases in pediatric patients: Methodology, utility, prognostication, and outcome 2010 Child's Nervous SystemVol 26 pg. 523-544. Warf B.C., Mugamba J., Kulkarni A.V. Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus in Uganda: Report of a scoring system that predicts success. Clinical article 2010 Journal of Neurosurgery: Pediatrics Vol 5 pg. 143-148. Warf B.C., Kulkarni A.V. Intraoperative assessment of cerebral aqueduct patency and cisternal scarring: Impact on success of endoscopic third ventriculostomy in 403 African children: Clinical article 2010 Journal of Neurosurgery: Pediatrics Vol 5 pg. 204-209. Kulkarni A.V., Hui S., Shams I., Donnelly R. Quality of life in obstructive hydrocephalus: Endoscopic third ventriculostomy compared to cerebrospinal fluid shunt 2010 Child's Nervous System Vol 26 pg. 75 -79. Dijkman B.G., Abouali J.A.K., Kooistra B.W., Conter H.J., Poolman R.W., Kulkarni A.V., Tornetta III P., Bhandari M. Twenty years of meta‐analyses in orthopaedic surgery: Has quality kept up with quantity? 2010 Journal of Bone and Joint Surgery ‐ Series A Vol 92 pg. 48-57. DR. JAMES RUTKA 2010 Northcott PA, Rutka JT, Taylor MD: Genomics of medulloblastoma: From Giemsabanding to next-generation sequencing in 20 years. Neurosurg Focus 2010: 28(1): pp E6. CPA Rutka JT, Berger MS, Couldwell WT, Selden NR: Neurogenomics and neuroproteomics. Neurosurg Focus 2010: 28(1): pp E1. CPA Bhardwaj RD, Mahmoddabadi SZ, Otsubo H, Snead OC, Rutka JT, Widjaja E: Diffusion tensor tractography detection of functional pathway for the spread of epileptiform activity between temporal lobe and rolandic lesion. Childs Nervous System 2010: 26: pp 185-190. C Nakahara Y, Northcott P, Li M, Kongkham P, Smith C, Yan H, Croul S, Ra Y, Eberhart C, Huang A, Bigner D, Grajkowska W, Van Meter T, Rutka JT, Taylor MD: Genetic and epigenetic inactivation of Kruppel-Like factor 4 in medulloblastoma. Neoplasia 2010: 12(1): pp 20-27. C Onvani S, Etame AB, Smith CA, Rutka JT: Genetics of medulloblastoma: clues for novel therapies. Expert Reviews 2010: 10(5): pp 811-823. SRI Widjaja E, Simao G, Mahmoodabadi SZ, Ochi A, Snead OC, Rutka JT, Otsubo H: Diffusion tensor imaging identifies changes in normal-appearing white matter within the epileptogenic zone in tuberous sclerosis complex. Epilepsy Research 2010: 89: pp 246253. C Kongkham P, Northcott PA, Croul SE, Smith CA, Taylor MD, Rutka JT: The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 2010: 29: pp 3017-3024. SRI Ng WH, Donner E, Go C, Abou-Hamden A, Rutka JT: Revision of vagal nerve stimulation (VNS) electrodes: review and report on use of ultra-sharp monopolar tip. Childs Nervous System 2010: 26: pp 1081-1084. SRI Li M, Lee KF, Lu y, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Oicard D, Zhou L, Boutros PC, Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A: Frequent amplification of chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 2010: 8;16(6): pp 533-546. C Ng WH, Mukhida K, Rutka JT: Image guidance and neuromonitoring in neurosurgery. Childs Nervous System 2010: 26: pp 491-502. SRI Lessard F, Morin F, Ivanchuk S, Langlois F, Stefanovsky V, Rutka JT, Moss T: The ARF Tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I. Molecular Cell 2010: 38: pp 539-550. CPA Gaetz W, Scantlebury N, Widjaja E, Rutka JT, Bouffet E, Rocket C, Dockstader C, Mabbott D: Mapping of the cortical spinal tracts using magnetoencephalography and diffusion tensor tractography in pediatric brain tumor patients. Childs Nervous System 2010. C Northcott P A, Korshunov A, Witt H, Hielscher T, Eberhart C, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD: Medulloblastoma comprises four distinct molecular variants. Journal of Clinical Oncology 2010: pp 1-12. C Chakraborty A, Rutka JT: Surgical approaches to epilepsy. Future Medicine Therapy 2010: 7(5): pp 467-479. SRI Rutka JT: Excellence in clinical neurosurgery: Practice and judgment make perfect. Clinical Neurosurgery 2010: 57: pp 69-78. SRI Rutka JT: Excellence in neurosurgical research: The neuro-oncology paradigm. Clinical Neurosurgery 2010: 57: pp 38-48. SRI Rutka JT, Wallace C: Excellence in neurosurgery program building: Enhancing the academic mission. Clinical Neurosurgery 2010: 57: pp 100-111. SRI Zhou L, Picard D, Ra y, Li M, Northcott PA, Hu Y, Steams D, Hawkins C, Taylor MD, Rutka JT, Der SD, Huang A: Silencing of thombospondin-1 is critical for Myc-induced metastatic phenotypes in medulloblastoma. Cancer Research 2010: 70(20): pp 1-12. C Ng WH, Ochi A, Rutka JT, Strantzas S, Holmes L, Otsubo H: Stimulation threshold potentials of intraoperative cortical motor mapping using monopolar trains of five in pediatric epilepsy surgery. Childs Nervous System 2010: 26: pp 675-679. C Ellis MJ, Kulkarni AV, Drake JM, Rutka JT, Armstrong D, Dirks PB: Intraoperative angiography during microsurgical removal of arteriovenous malformations in children. Journal Neurosurgery Pediatric 2010: 6(5): pp 435-443. C Wilson JR, Vachhrajani S, Li J, Hawkins C, Rutka JT: Pediatric sinonasal undifferentiated carcinoma: case report and literature review. Canadian Journal of Neurological Science 2010: 37(6): pp 873-877. SRI Restrepo A, Smith CA, Agnihotri S, Shekarforoush M, Kongkham P, Seol HJ, Rutka JT: Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas. Neuro-Oncology 2010: 13(1): pp 42-50. SRI Kongkham PN, Onvani S, Smith CA, Rutka JT: Inhibition of the MET receptor tyrosine kinase as a novel therapeutic strategy in medulloblastoma. Translational Oncology 2010: 3(6): pp 336-43. SRI Kwan A, Ng WH, Otsubo H, Ochi A, Sneas OC, Tamber MS, Rutka JT: Hemispherectomy for the control of intractable epilepsy in childhood: Comparison of 2 surgical techniques in a single institution. Neurosurgery 2010: 67: pp 429-436. SRI Kim BYS, Rutka JT, Chan WCW: Nanomedicine. The New England Journal of Medicine 2010: 363(25): pp 2434-43. CPA DR. MICHAEL TAYLOR 2010 Kongkham PK,Northcott PA, Croul SE, Smith CA, Taylor MD, Rutka JT. The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene. 2010. 29: 3017-3024. Coauthor or Collaborator. Hudson TJ, Anderson W, Aretz A, Barker AD, Bell C, ETAL, Taylor MD, ETAL, Spellman PT, Stunnenberg HG, Wainwright BJ, Wilson RK, Yang H. International Network of Cancer Genome Projects. International Cancer Genome Consortium. Nature, 2010. Vol 464 (993-998). Coauthor or Collaborator. Lafay-Cousin L, Mabbot DJ, Halliday W, Taylor MD, Tabori U, Kamaly-Asi I, Kulkarni A, Bartels U, Greenberg M, Bouffet E. Use of Ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. J. Neurosurg Pediatric 2010. 5: 615-621. Coauthor or Collaborator. Finkelstein-Shechter T, Gassas A, Mabbot D, Huang A, Bartels U, Tabori U, Laura J, Hawkins C, Taylor M. Bouffet E. Atypical Teratoid or Rhabdoid Tumors: Improved Outcome with High Dose Chemotherapy. J Pediatr Hematol Oncol. 32(5): 182-6. 2010. Coauthor or Collaborator. Dubuc AM, Northcott PA, Mack S, Witt H, Pfister S, Taylor MD. The Genetics of Pediatric Brain Tumors. Curr Neurol Neurosci Rep. 10: 215-223. 2010. Senior Responsible Author. Christopher Traenka, Marc Remke, Andrey Korshunov, Sebastian Bender, Thomas Hielscher, Paul A Northcott, Hendrik Witt, Marina Ryzhova, Jörg Felsberg, Axel Benner, Stephanie Riester, Wolfram Scheurlen, Thomas GP Grunewald, Andreas von Deimling, Andreas E. Kulozik, Guido Reifenberger, Michael D Taylor, Peter Lichter, Elke Butt, and Stefan M Pfister. Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma. Cancer Research 2010. Vol 70(20). 8003-8014. Coauthor or Collaborator. Finkelstein-Shechter T, Gassas A, Mabbot D, Huang A, Bartels U, Tabori U, Laura J, Hawkins C, Taylor M. Bouffet E. Atypical Teratoid or Rhabdoid Tumors: Improved Outcome with High Dose Chemotherapy. J Pediatr Hematol Oncol. 2010. 32(5). 182-6. Coauthor or Collaborator. Milde T, Oehme I, Korshunov A, Kopp-Schneider, Remke M, Northcott P, Deubzer HE, Lodrini M, Taylor MD, von Deimling A, Pfister S, Witt O. HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth. Clin Caner Res. 2010. 16(12); 3240-3452. Coauthor or Collaborator. Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SES, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang Y, Coyle B, Atkinson J, DeWire M, Kranenberg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison D, Taylor MD, Grundy RG, Gilbertson RJ. Cross species genomics matches driver mutations and cell compartments to model ependymoma. Nature 2010. Vol 466. Pges 632-636. Coauthor or Collaborator. Pfister SM, Korshunov A, Kool M, Hasselblatt M, Eberhart C, Taylor MD. Molecular Diagnostics of CNS Embryonal Tumors. Acta Neuropathologica 2010. Vol 120: 553-566. Senior Responsible Author. U-King-Im JM, Taylor MD, Raybaud C. Posterior fossa ependymomas: new radiological classification with surgical correlation. Child‘s Nervous System. 2010. Vol 26: 17651772. Coauthor or Collaborator. Dubuc AM, Northcott PA, Kenney AM, Taylor MD. Calculating a Cure for Cancer: Managing Medulloblastoma MATH1-ematically. Expert Review of Neurotherapeutics 2010. Vol 10(10): 1489-92. Senior Responsible Author. Zhou L, Picard D, Ra YS, Li M, Northcott PA, Hu Y, Stearns D, Hawkins C, Taylor MD, Rutka J, Der SD, Huang A. Silencing of Thrombospondin-1 is Critical for MycInduced Metastatic Phenotype in Medulloblastoma. Cancer Research 2010. Vol 70(20), 8199-8210. Coauthor or Collaborator. Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, von Buren AO, Wittman A, Schottler A, Jorch N, Graf N, Kulozik AE, Witt O, Scheurlen W, von Deimling A, Rutkowski S, Taylor MD, Tabori U, Lichter P, Korshunov A, Pfister SM. TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma. Journal of Clinical Oncology 2010. Vol 28, 5188-5196. Coauthor or Collaborator. Yukiko Nakahara, Paul A. Northcott, Meihua Li, Paul N. Kongkham, Hai Yan, Sidney Croul, Young-Shin Ra, Charles Eberhart, Annie Huang, James T. Rutka, Michael D Taylor. Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma. Neoplasia. 12(1), 20-27. 2010. Senior Responsible Author. David C. Adamson, Qun Shi, Matthew J.Wortham, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan. OTX2 is a commonly amplified medulloblastoma oncogene that promotes tumor progression, Maintains tumor cell survival, and regulates c-Myc. Cancer Research. 2010. 70(1), 181-191. Coauthor or Collaborator. Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan Q, Goldeberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe X, Flynn Gilmer HC, Collins R, Nagoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L. Pleiotropic role for MYCN in medulloblastoma. Genes and Development. 24, 1059-1072. 2010. Coauthor or Collaborator. Tabori U, Baskin B, Alon N, Taylor MD, Ray PN, Bouffet E, Malkin D, Hawkins C. Universal poor survival in children with medulloblastoma harbouring somatic TP53 mutations. Journal of Clinical Oncology. 2010.28(8). 1345-1350. Coauthor or Collaborator. Lam C, Bouffet E, Tabori U, Mabbott D, Taylor MD, Bartels U. Rapamycin (Sirolimus) in Tuberous Sclerosis Associated Pediatric Central Nervous System Tumors. Pediatric Blood and Cancer. 54(3), 476-9. 2010. Coauthor or Collaborator. Northcott PA, Rutka JT, Taylor MD. Genomics of Medulloblastoma. From G-banding to Next Gen in 20 years. Neurosurgery Focus. 28(1), 1-20. 2010. Senior Responsible Author