Stem Cell Research at UC Davis
Disease Teams- Basic, Translational and Clinical Faculty Members
Liver disease Adult stem cell trial pending at UC Davis
 Collaboration with UCSF
 hESC trial in development/CIRM Translational grant approved
 Collaborative stem cell trials ongoing in Egypt (Autologous CD34+ cells)
 CIRM and NIH funded team
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Mark Zern, M.D.
Jan Nolta, Ph.D.
Alice Tarantal, Ph.D.
Alexander Revzin, Ph.D.
Jian Wu, M.D., Ph.D.
Ping Zhou, Ph.D.
Natalie Torok, M.D.
Yu-you Duan, Ph.D.
Eye degeneration/blindness Adult stem cell trial for retinal repair pending – IND submitted-collaboration with
Betastem
 hESC studies ongoing-retina specification
 Collaborative studies with the vet school for dry eye syndrome
 Corneal development from stem cells – ongoing
 Funded by foundations
9. David Telander, M.D.
10. Leonard Hjelmeland, Ph.D.
11. Susanna Parks, M.D.
12. Rivkah Isseroff, M.D.
13. Ivan Schwab, M.D.
14. Chris Murphy, Ph.D.
15. Paul Russell, Ph.D.
16. Tingrui Pan, Ph.D.
Jan Nolta, Ph.D.
17. Fu-Tong Liu, M.D.
Vascular group/Peripheral artery disease, Heart disease, heart attacks
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Cardiac Adult stem cell trial initiated 10-09 (MSC to treat heart attack, Osiris
sponsored)
Adult stem cell peripheral artery disease clinical trials pending at the UCD Vascular
Center – partnering with Aldagen
Research collaboration with Thermogenesis, Rancho Cordova, CA
hESC/iPSC studies ongoing
Po1 including heart team in preparation- organ bioengineering
Collaboration with Travis AFB- DOD grant
18. John Laird, M.D.
19. William Pevec, MD
20. Jeffrey Southard, MD
21. Walter (Doug) Boyd, MD
Jan Nolta, Ph.D.
22. Fitz-Roy Curry, Ph.D.
23. John Rutledge, Ph.D.
24. Nipavan Chiamvimonvat, M.D.
25. Kim Janatpour, M.D.
26. Dan Yan Xu, M.D., Ph.D.
Alice Tarantal, Ph.D.
27. Anne Knowlton, M.D.
28. Jidong Fu, Ph.D.
29. Reggie Low, M.D.
30. Leigh Griffiths, Ph.D.
31. Deborah Lieu, Ph.D.
Hematopoiesis- Regeneration of the Blood-forming system
 Bone Marrow transplantation ongoing (the “original” stem cell therapy)
 Novel Clinical trials pending
 iPSC to hematopoietic stem cell differentiation under development
 Cord blood collection efforts are developing through AB52
 hESC research ongoing in xenograft and non-human primate models
 NIH funding- Nolta, Tarantal, Dandekar
 Foundation funding- Anderson
 CIRM funding- W. Murphy and Nolta- Immunology grant
 Cord blood- Children’s network funding (Walker, Pontow, Nolta)
32. Carol Richman, M.D.
33. William Murphy, Ph.D.
34. Cheryl Walker, MD
35. Eric Gershwin, MD
36. Christopher Bowlus, M.D.
37. Joe Tuscano, M.D.
38. Doug Taylor, M.D.
39. Elena Nedelcu, MD
Alice Tarantal, Ph.D.
40. Ursula Esser, Ph.D.
Jan Nolta, Ph.D.
41. Gerhard Bauer, MD
42. Kit Lam, M.D.
43. Paul Knoepfler, Ph.D.
44. Leonor Fernando, MD
45. Ralph Green, M.D.
46. Kim Janatpour, Ph.D.
47. Satya Dandekar, M.D.
48. Scott Simon, Ph.D.
49. Noriko Satake, MD
Skin disorders; non-healing skin ulcers, burns Clinical Cell Therapy trial ongoing for wound repair
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New trials pending – Isseroff/MSC treated with beta blockers
GMP Contract with Stanford to generate skin sheets from iPSC for Epidermolysis
Bullosa
Program project submitted- Isseroff/Nolta/C. Murphy
Rivkah Isseroff
50. Tina Palmieri
51. Min Zhao
52. Fu-Tong Liu
53. David Greenhalgh
HIV (and other virus) treatment using stem cells
 Collaborative adult stem cell and hESC Research ongoing
 Gene therapy to render hematopoietic stem cells HIV-resistant
 Targeting vector technology – GMP contracting for vector production
 Modified iPSC-derived stem cell transplantation to regenerate an immune system
 Adult stem cell transplantation ongoing for patients with HIV-induced lymphoma
 Contracting to regenerate human immune system in our Xenotransplantation mouse
core: Iperian, HuMurine
Gerhard Bauer, MD
54. David Asmuth, MD
55. Richard Pollard, MD
56. Joe Anderson, Ph.D.
57. Satya Dandekar, Ph.D.
58. Jon Walker, MT
59. Suzanne Pontow, PH.D.
60. Christopher Polage, MD
61. Paul Luciw, Ph.D.
62. Michael George, Ph.D.
Jan Nolta, Ph.D.
Neurodegenerative (Parkinson’s, Huntington’s, Alzheimer’s diseases and ALS) and
neurodevelopmental diseases (autism, fragile X, FXTAS) and injury (stroke, TBI)
 Research on clinically relevant hESC lines and neural differentiation
 iPSC to neuronal development to study autism, fragile X, FXTAS- funded through NIh
Challenge grant (one of 200 awarded from 25,000 applications)- Hagerman, Nolta,
Pessah
 hESC and MSC-based therapies for Parkinson’s disease in development
 Clinical trial for Huntington’s disease in development: MSC to deliver anti-htt siRNA
 MARBLES study ongoing to examine umbilical cord stem cells/iPSC in autism
 Philanthropy- HD community, Roberson foundation, Pue family donations to Drs.
Nolta and Wheelock
 CIRM translational grant for Huntington’s disease - Nolta/Wheelock
 Alzheimer’s Center of excellence- DeCarli
 Huntington’s disease Center of excellence
63. Vicki Wheelock, M.D.
64. Lin Zhang, MD
65. Michael Rogawski, MD, Ph.D.
66. Charles DeCarli, M.D.
67. Fred Gorin, M.D.
68. Huguette Albrecht, Ph.D.
69. Richard Latchaw, M.D.
70. Wenbin Deng, Ph.D.
71. David Pleasure, M.D.
Paul Knoepfler, Ph.D
72. James Angelastro, Ph.D.
73. Randi Hagerman, MD
74. Isaac Pessah
75. Paul Hagerman, Ph.D.
76. Cheryl Walker, MD
77. Paul Ashwood, Ph.D.
Suzanne Pontow, Ph.D.
Jan Nolta, Ph.D.
78. Bjorn Oskarsson, MD
79. Nannette Joyce, MD
80. Martha O’Donnell, Ph.D.
81. Frank Sharp. Ph.D.
82. Karen Sigvardt, MD
83. Pablo Ross, Ph.D.
Lung and Kidney disease
 Adult stem cells to reduce inflammation and fibrosis
 hESC research ongoing in non-human primate models
 Asthma and environmental toxin models
 Kidney bioengineering from hESC/iPSC
 NIh funding- Tarantal
 Fenwick Family Philanthropy-Nolta/Tarantal
84. Dallas Hyde, Ph.D.
85. Reen Wu, Ph.D.
86. Kent Pinkerton, Ph.D.
87. Cynthia Batchelder, Ph.D.
Alice Tarantal, Ph.D
Eric Gershwin, MD
88. Thomas Depner, M.D.
Cartilage, bone and tendon Pre-clinical trials ongoing in the equine system and controlled sheep trials
 Human trials initiated in 2008- bone marrow stem cells harvested and infused for
avascular necrosis and non-union fractures (Lee and Jamali)
 Racehorses treated with autologous MSC implanted in novel biomatrices for bone
 Sheep models for bone and cartilage repair
 hESC-derived mesenchymal stem cells
 Osteoporosis models- MSC targeting to bone
 Corporate collaborations; Synthes, Thermogenesis, Cormatrix
 Randall family Philanthropy
89. Hari Reddi, Ph.D.
90. Kyriacos Athanasiou
91. Martin Vidal, PH.D., DVM
92. John Peters, MD
93. Kent Leach, Ph.D.
94. Mark Lee, MD
95. Amir Jamali, MD
96. Denis Dwyre, MD
Jan Nolta, Ph.D.
97. Nancy Lane, M.D.
98. Simeon Boyd, M.D.
99. Jinoh Kim, Ph.D.
100. Wei Yao, MD, Ph.D.
101. Kei Hayashi
Elena Nedelcu
Bladder/ Gastrointestinal Clinical trial sponsored by Osiris pending; adult MSC to treat Crohn’s disease
 Intestinal bioengineering/ repair in HIV
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Eric Kurzrock
103. Ravi Thangappan
104. Thomas Prindiville
Jan Nolta
Ping Zhou
Chong-xian Pan, M.D.
Kit Lam M.D.
David Asmuth, Ph.D.
Hearing/ Inner ear cilia repair
 Adult and hESC studies ongoing – CIRM funded
105. Ebenezer Yamoah
106. LiPing Nie, Ph.D.
107. Karen Doyle, MD
Immunology/ immunotherapeutics
 Clinical trial pending – Biliary Cirrhosis (Phase 1 at Northwestern)
 Immunotherapy for cancer stem cells
 CIRM funding- Murphy/Nolta Immunology grant
Eric Gershwin, M.D.
Christopher Bowlus, M.D.
Carlo Selmi, M.D., Ph.D.
Joseph Tuscano, M.D.
Kit Lam
108. William Murphy, Ph.D.
109. Merhdad Abedi
Carol Richman, M.D.
Doug Taylor, M.D.
Cancer Stem Cells
 Breast cancer studies – large group of researchers in addition to the CSC studies
 Studies ongoing to define and defeat cancer stem cells in pancreatic, prostate, brain,
liver cancer, and leukemia
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Novel cancer stem cell-targeting ligands identified via combinatorial chemistry- one
clinical trial in development
Leukemic stem cell engraftment models established for drug testing – xenograft core
UpA inhibitor developed to target glioblastoma stem cells – clinical trial in development
Over $7 million in cancer stem cell funding- strong collaborations between stem cell
program and cancer center
Levy family Philanthropy
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Chong-xian Pan, M.D.
Ralph Devere-White, M.D.
Shiro Urayama, MD
Xinbin Chen, Ph.D.
Kent Erickson, Ph.D.
Peter Cala, Ph.D.
Douglas Taylor, M.D.
Fred Gorin, M.D.
Ruben Fragoso, MD
Rudy Schrot, M.D.
James Boggan, MD
Alexander (Sandy) Borowsky, M.D.
Sean Deane, MD
Robert Cardiff, Ph.D.
Colleen Sweeney, Ph.D.
Kit Lam, MD
Noriko Satake, MD
Paul Knoepfler, Ph.D
James Angelastro, Ph.D.
William Murphy, Ph.D.
“Bench to the bedside” GMP/Scale-up/Translation of stem cell therapies to the Clinic/
CTSC interaction
Clinical trials of stem cell therapy: paperwork for IND application ongoing for 9 disease teams
Others under study at the level of good laboratory practice/ scale-up
$1.2 million induced pluripotent stem cell manufacturing contract with Stanford
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Gerhard Bauer, M.D.
Jan Nolta, Ph.D.
Lars Berglund, M.D.
Elva Diaz, Ph.D.
Geralyn Annett, CLS
Primo Lara, MD
Kate Marusina, Ph.D.
Alice Tarantal, Ph.D.
Jon Walker, M.T.
Carol Richman, M.D.
Imaging of stem cells at the bench and in the body, Center for Biophotonics
CIRM funding to better define siRNA transfer form MSC to treat Huntington’s disease
Sutcliffe training grant funding from NBIB for the next generation of radiochemists
129. Simon Cherry, Ph.D.
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Julie Sutcliffe, Ph.D.
Ramsey Badawi, Ph.D.
Grete Adamson, Ph.D.
Thomas Huser, Ph.D.
Dennis Mathews, Ph.D.
Frank Chuang, Ph.D.
Sebastian Wachsmann-Hogiu, Ph.D.
James Boggan, M.D.
Frank Yaghmaie, Ph.D.
Cristina Davis
Alice Tarantal, Ph.D.
Jan Nolta, Ph.D.
Stem Cells to cure horses, dogs and cats with cancer and tissue injuries
 Veterinary clinical trials ongoing using the animal’s own stem cells: equine bone
fractures, tendon injuries and cartilage/hoof damage
 Autologous adipose-derived stem cells to treat canines with spinal cord injury
 Novel drugs tested for canine glioblastoma
 Equine cord blood bank has been established. Units thawed to successfully treat bone
cysts
 Numerous models for athletic injuries- sheep, equine
 Corporate collaborations; Synthes, Thermogenesis, Cormatrix
 Randall family Philanthropy
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Claire Yellowly, Ph.D.
Greg Ferraro, DVM
Susan Stover, DVM
Murray Gardner, DVM
Martin Vidal, Ph.D., DVM
Dori Borjesson, Ph.D.
Larry Galuppo, DVM
Eric Wisener, DVM
Xinbin Chen, Ph.D.
Richard Vulliet, DVM, Ph.D.
Sean Owens, Ph.D.
Michael Kent, DVM
Peter Dickinson, DVM
Stem Cell Bioethics
152. Mark Yarborough, PhD (Dean's Professor of Bioethics)
153. Lisa Ikemoto, J.D.
154. Ben Rich, Ph. D., J.D.
Revision October 2010