HARVARD MEDICAL SCHOOL
CURRICULUM VITAE
Part I:
General Information
Date Prepared:
July 31, 2008
Name:
Leslie Eric Silberstein, M.D.
Office Address:
Children’s Hospital, Boston
Karp Family Research Building
10th floor, room 10217
1 Blackfan Circle
Boston, Massachusetts 02115
Home Address:
500 Commercial Street
Boston, Massachusetts 02109
E-mail:
leslie.silberstein@childrens.harvard.edu
Phone: (617) 919-2588
Fax: (617) 730-0765
Place of Birth:
New York, NY
Education:
1963 – 1969
1969 - 1977
B.A.
Gymnasium-B Peter Stuyvesant Lyceum,
Curacao, Netherlands Antilles
M.D. College and Medical School
University of Leiden
Leiden, The Netherlands
Postdoctoral Training and Fellowship Appointments:
1977-1978
Intern
Internal Medicine
1978-1980
Resident
Internal Medicine
Georgetown University
Medical Division
D.C. General Hospital
Washington, D.C. 20003
St. Francis Hospital and
Medical Center
Hartford, CT 06105
Leslie Eric Silberstein, M.D.
Curriculum Vitae
Page 2
1980-1981
Clin. Fellow
Hematology/Oncology
Tufts-New England
Medical Center Hospital
Department of Medicine
Boston, MA 02111
1981-1983
Fellow
Blood Bank
Hematology/Oncology
Tufts-New England
Medical Center Hospital
Boston, MA 02111
Licensure and Certification:
1980
American Board of Internal Medicine – Member #77204
1980
Board of Registration in Medicine, Massachusetts
1982
American Board of Internal Medicine, subspecialty in Hematology
Member #77204
1984
American Board of Pathology, subspecialty in Blood Banking
Academic Appointments:
1983-1987
1988-1994
1994-2000
Assistant Professor
Associate Professor
Professor
2000-present
Professor
Hospital or Affiliated Institution Appointments:
1983-1985
Assistant Director, Blood Bank
1985-2000
Director, Blood Bank and
Transfusion Medicine Section
1992-2000
Associate Director, Bone Marrow
Transplant Program
2000-present Director, Joint Program in
Transfusion Medicine
2005-present
Director, Center for Human Cell Therapy
Departments of Pathology,
Laboratory Medicine, and Medicine
University of Pennsylvania
Philadelphia, PA 19104
Harvard Medical School
Department of Pathology
Brigham and Women’s Hospital,
Children’s Hospital, Dana-Farber
Cancer Institute.
Boston, MA 02115
Hospital of the University of
Pennsylvania
Hospital of the University of
Pennsylvania
University of Pennsylvania
Cancer Center
Children's Hospital, Boston
Brigham and Women’s Hospital
Dana-Farber Cancer Institute
CBR Institute for Biomedical
Research
Awards, Honors and Membership in Honorary Societies:
Leslie Eric Silberstein, M.D.
1980-1982
19922000
Page 3
American Cancer Society Fellowship Award
American Society of Clinical Investigation
Henry Kunkel Society, Rockefeller University.
Membership in Professional and Scientific Societies:
1983-present American Society of Hematology
1983-present American Association for the
Advancement of Science
1983-present Pennsylvania Association of Blood Banks
1984-present American Red Cross, Penn Jersey Region
1984-present American Federation for Clinical Research
1985-present American Association of Pathologists
1985-1988
American Association of Blood Banks
1986-1989
Curriculum Vitae
1986-1993
Philadelphia Society of Hematology/
Oncology
American Association of Blood Banks
1986-1990
American Association of Blood Banks
1987-1990
American Association of Blood Banks
1988-present American Association of Immunologists
1988-present Greater Philadelphia Hospitals
Blood Bank Association
1990
Greater Philadelphia Hospitals
Blood Bank Association
1991-1994
American Association of Blood Banks
Member
Member
Member
Member, Medical Advisory Board
Member
Member
Member, Committee on Self-Testing
and Review
Secretary/Treasurer
Chairman, Committee on
Transfusion Practices
Elected by Membership, Scientific
Section Coordinating Committee
Liaison Member, Molecular and
Cellular Biotechnology
Member
Member, Board of Directors
Vice President
Member, Scientific Program
Committee
1992-1998
American Society of Hematology
Member, Subcommittee on
Transfusion Medicine
1993-present American Society of Clinical Investigation Member
1993-present American Association of Blood Banks
Member, Transfusion Medicine
Research Strategies Committee
1994-1997
American Association of Blood Banks
Chairman, Scientific Program
Committee
1994-2002
National Blood Foundation
Member
1995-present Lymphoma Research Foundation of
Member, Scientific Review
America, Inc.
Committee
1995-1996
American Society of Hematology
Chairman, Subcommittee on
Transfusion Medicine
1996
Philadelphia Immunology Conference
Co-Chairman
1996-2002
American Board of Internal Medicine
Member, Subspecialty Board on
Hematology
Leslie Eric Silberstein, M.D.
Curriculum Vitae
1996
Coordinating Reviewer of Abstracts,
Annual Meeting
Member, Leukocyte Reduction
Committee
Chair, Grants Review Committee
Board Member
Member, Nominating Committee
Scientific Committee on Transfusion
Medicine
Member, Scientific Advisory Board
Co-Chair of 2003 Scientific Program
Program Head of Translational
Research
Member, Advisory Committee
American Society of Hematology
1998-present American Association of Blood Banks
2000
2000-present
2000-present
2001-present
National Blood Foundation
National Blood Foundation
American Association of Blood Banks
American Society of Hematology
2001-present Blood Research Institute, Milwaukee, WI
2003
American Society of Hematology
2005
Harvard Stem Cell Institute
2006-present K-12 Program in Non-Malignant
Hematology Program, HMS
2006
American Association of Blood Banks
2007
Committee in Immunology, HMS
Page 4
Standards Program Committee
Membership Subcommittee
Editorial Boards:
Reviewer for Journals, Publishers, and Abstracts:
 Anesthesia and Analgesia
 Annals of Internal Medicine
 Acta Haematologica
 Blood
 Journal of Clinical Apheresis
 Journal of Clinical Investigation
 Journal of Immunology
 New England Journal of Medicine
 Transfusion
 Williams and Wilkins Publishers
 Internal Immunology
 International Blood Group Reference Laboratory, Bristol, UK
 Canadian Red Cross Society, Research and Development Program
1990-present Member
1992-present Editor
Journal: Pathobiology
Textbook: “Hematology: Basic Principles and Practice.”
Churchill Livingstone. R. Hoffman, E. Benz, S. Shattil, B. Furie,
H. Cohen, L.E. Silberstein eds.
1993-present Member
Journal: Laboratory and Clinical Immunology
1995-2001
Assoc. Editor Journal of Immunology
1995
Editor
Textbook: “Immunoglobin Gene Expression in Development and
Disease.” Annals of the New York Academy of Sciences. P.
Casali and L.E. Silberstein eds.
1996-2001
Assoc. Editor Transfusion
Leslie Eric Silberstein, M.D.
1996
Member
2001
Member
2001
Member
2002-present Editor
Curriculum Vitae
Page 5
Nouvelle Revue Francaise d’Hematologie (Hematology and Cell
Therapy)
Journal of Autoimmunity
Blood
Textbook: “Blood Banking and Transfusion Medicine: Basic
Principles and Practice.” Christopher Hillyer, P. Ness, K.
Anderson, L.E. Silberstein eds.
Committees for the National Institutes of Health:
1994
19961997-2001
1997 1997 19981998
19981999200020012004200420052005
2005
2005
2006
2006
2007
Ad Hoc Reviewer for N.I.H. Study Section for RFA on Immunobiology of
AIDS-related lymphoma.
Reviewer, Special Emphasis Panel for N.I.H. study section to review
program projects on transfusion biology.
Member of Program Project Review Committee, National Heart, Lung,
and Blood Institute; Four-year appointment.
Invited member of Special Emphasis Panel, National Heart, Lung, Blood
Institute, Bethesda, MD.
Reviewer, Centers for AIDS Research, National Institute of Allergy and
Infectious Diseases, Bethesda, MD.
Immunobiology Study Section, (Ad Hoc member, 10/98)
Chair, Immunology, “Topics in Transfusion Medicine Research”,
sponsored by the National Heart, Lung and Blood Institute, Bethesda, MD.
September 14 and 15, 1998.
ASH Academic Awards Committee/Reviewer for Year 2000 Awards.
Invited member of National Cancer Institute Research Evaluation and
Decision Panel of the AIDS Specimen Bank.
Chair, Review Committee of REDS Program, NHLBI
Special emphasis panel. National Heart, Lung and Blood Institute.
“Research on stem cell therapies”
Chair, Review Committee of REDS Program, NHLBI
Reviewer, Tumor Microenvironment (TME) Program, NIH
Scientific Committee Chairs Meeting, ASH, Washington, DC
Chair, Review Committee, Special Emphasis Panel, Review of PPG
Applications (PO1s), February 23, 2005
Reviewer, NHLBI Loan Repayment Program Review of Applications,
Online Review, March 7-26, 2005
Consultant, NHLBI Special Emphasis Panel, SCCOR in Transfusion
Biology and Medicine , March, 29, 2005
NIH P01 Review – Division of Extramural Affairs, Review Branch, April
25-26, 2006
NHLBI – Strategic Planning Meeting, “Research in Global Blood Safety
and Availability (Domestic and International)” May 9, 2006
NIH TME Study Section, Bethesda, MD February 12-13, 2007
Leslie Eric Silberstein, M.D.
2007
2007
Curriculum Vitae
Page 6
NIH Operational Review of the Department of Transfusion Medicine.
Bethesda, MD. March 5-7, 2007.
NIH Grantees’ Meeting for SCCOR in Transfusion Biology and Medicine
and Working Group on Immune Consequences of Allogeneic Exposures.
Bethesda, MD. May 9, 2007.
Principal Investigator of Grants:
1987 - 1988
Purification and Characterization of Monoclonal Red Blood Cell
Autoantibodies Derived from B-Cell Lines.
Biomedical Research Support, University of Pennsylvania
School of Medicine
$10,000 ADC
1987 - 1988
A Double-Blind, Placebo - Controlled Study to Determine Whether RHuEPO Can Facilitate Presurgical Autologous Blood Donations and
Determine its Safety for this Purpose.
Ortho Pharmaceutical Corporation
$25,000
5/88 - 4/93
The Human B-Cell Repertoire of Erythrocyte Autoantibodies.
National Institute of Diabetes/Digestive/Kidney Diseases National
Institutes of Health, Bethesda, MD; R29DK39065-01
$70,000 ADC
9/89 - 9/94
Analyses of Methods of Lymphocyte Separation for Sterile Culture and
Flow Cytometry.
Becton-Dickinson, Mountain View, CA
$55,000 ADC
12/89 - 12/92
1/90 - 1/91
10/89 - 10/95
3/90 - 3/91
6/91 - 6/93
7/91 - 6/96
Harvest of Enriched Human Monocyte Preparations for the
Characterization of Interleukin-1
Merck, Sharp & Dohme, Rahway, NJ
$20,500 ADC
Variable Region Gene Alterations in Human B-Cell Neoplasia With
Autoreactive Specificity
Research Foundation, University of Pennsylvania, School of Medicine
$4,500
5% effort on Transfusion Medicine Academic Award Grant Award to Dr.
Urs Giger/University of Pennsylvania, School of Veterinary
Medicine
$4,000 per year
Molecular Characterization of the Rhesus (Rh) Blood Group Antigen
Complex
Biomedical Research Support, University of Pennsylvania
School of Medicine
$5,900
Cold Agglutinins in Relation to Autoimmunity, Autoimmune Disease, and
Neoplasia
NATO Collaborative Research Grants Program
$10,000
15% effort on Transfusion Medicine Academic Award Grant Award to Dr.
Leigh Jefferies.
Leslie Eric Silberstein, M.D.
9/91 - 9/96
7/94 - 7/99
1/94 - 1/95
8/94 - 8/99
12/94 -12/98
1/96 - 1/98
2/96 - 2/01
9/96 - 9/01
7/99-7/04
7/01-7/11
09/01-08/06
9/02-8/07
8/02-2/04
Curriculum Vitae
Page 7
University of Pennsylvania, School of Medicine; National Heart, Lung
and Blood Institute; National Institutes of Health, Bethesda MD; # 1 K07
HL02673 - 01
$460,387 TDC
National Heart, Lung, and Blood Institutes of Health, Bethesda MD; #1
T35 HL07719-01; Short-Term Training for Minority Students Program;
5% effort
$119,475 TDC
National Heart, Lung, and Blood Institutes of Health, Bethesda MD;
Academic Transfusion Medicine Training Program;
1T322HL07775-01; 5% effort
$343,980 TDC
Lupus Foundation of Philadelphia, "Pathogenesis of autoimmune
hemolysis in SLE"
$15,000 TDC
National Cancer Institute, "HIV associated B cell activation and
lymphoma development"; RO1CA65394 - 20% effort
$748,702 TDC
National Institute of Diabetes, Digestive and Kidney Diseases.
RO1DK39065-06-20% effort: “Pathogenesis of Autoimmune Hemolytic
Anemia”
$785,617 TDC
National Institute of Child Health and Human Development R44
HD31812-02-Consultant “Prenatal Blood Group Analysis in High Risk
Pregnancy” (ATGC)
$323,493 TDC
National Heart, Lung and Blood Institute, Bethesda, MD; #1P50HL5451601 - 37.5% effort "Cellular & Humoral Aspects of Immunomodulation"
$9,299,732 TDC
National Heart, Lung, and Blood Institute of Health, Bethesda, MD;
#2T35 HL07719-06; Short-Term Training for Minority Students Program;
5% effort
$108,750 TDC
National Heart, Lung, and Blood Institute of Health, Bethesda, MD;
Academic Transfusion Medicine Training Program; 2T32HL07775;
$634,722 TDC
National Heart, Lung, and Blood Institute of Health, Bethesda, MD;
Academic Transfusion Medicine Training Program; 2T32HL66987;
$1,653,057 TDC
National Heart, Lung, and Blood Institute of Health, Bethesda, MD
P01 HL056949; (PI: Denisa Wagner): Adhesion Molecules in Transfusion
Biology. Project Leader, “Role of Chemokine-Mediated Adhesion in B
Lymphopoiesis.”
$234,069
National Heart, Lung, and Blood Institute of Health, Bethesda, MD;
“Transfusion Medicine/Hemostasis Clinical Research” Co-PI;
1U01HL72291 – 5% effort
$252,587
Baxter Healthcare Corporation, “S-303 Treated Red Blood Cell Use in
Patients Requiring Chronic Transfusion Support” Investigator; RBC3B01
Leslie Eric Silberstein, M.D.
7/04-6/09
Curriculum Vitae
Page 8
- 4% effort
$120,586
National Institutes of Health; “Center for Human Cell Therapy”; Principal
Investigator; 1 R24 HL074355-01
$12,600,000
Regional, national, or international contributions:
Invited Presentations
1/31/91
"B-cell Origin of Cold Agglutinins" - Symposium on Autoimmunity and
Immunology, Tufts University, Boston, Massachusetts
2/6/91
"The Role of Autoreactivity in Human B-cell Neoplasia" - Medical
Biology Institute, La Jolla, California
3/26/91
"The Role of Autoreactivity in Human B-cell Neoplasia" - University of
California, San Diego, Department of Medicine, CA
9/10/91
"The Relationship Between Autoreactivity and Human B-Cell Neoplasia"
- Blood Center of Southeastern Wisconsin
6/6/92
"Autoreactive B-cell Neoplasms" - Tenovus Research Institute; Molecular
Immunology Group, Southampton, United Kingdom
7/15/92
"The Relationship Between Self Reactive B-cells and Lymphomagenesis",
GenPharm International Corp., Mountainview, CA.
10/5/92
"B-cell Origin of Cold Agglutinins", International Symposium on
Immunology of Proteins and Peptides, Banff, Canada.
12/5/92
"Pathologic Cold Agglutinins Recognize i, I and PR2 Determinants on
Both Murine and Human Lymphocyte Subsets", American Society of
Hematology Annual Meeting, Anaheim, CA.
12/5-7/92
Reviewer of abstracts and Moderator for the session on "Lymphocytes and
Immunology" at the American Society of Hematology Annual Meeting,
Anaheim, CA.
4/13/93
"The Role of Self Reactivity in Lymphomagenesis" Departments of
Pediatrics and Medicine, University of Rochester, Rochester, NY.
4/23-24/93
"The Origin of Red Cell Autoantibodies" at Harvard-Yale Update in
Transfusion Medicine, Boston, MA.
5/20/93
"Origin of Naturally Occurring Versus Pathogenic Cold Agglutinins.
Fundamental Aspects of Autoimmunity" - NATO conference, Acqua
Fredda Di Maratea, Italy.
10/12/93
"B-cell Responses to Antigens", Hoxworth Blood Center, Cincinnati, OH.
10/25/93
"The Antibody Response to Antigen" at the American Association of
Blood Banks Annual Meeting, Miami, FL.
2/22/94
"Role of Self-reactivity in Lymphomagenesis", Department of Laboratory
Medicine, Yale University, New Haven, CT.
5/16/94
"Role of Self-reactivity in Lymphomagenesis", North Shore University
Hospital, Manhasset, N.Y.
7/3-17/94
Chair: New York Academy of Sciences sponsored conference entitled:
"Immunoglobulin Gene Expression in Development and Disease",
Montreal, Canada.
Leslie Eric Silberstein, M.D.
12/3/94
2/9/95
6/5/95
6/9/95
6/24/95
10/10/95
10/15/95
11/12/95
11/13/95
12/3/95
2/26/96
3/7/96
5/16/96
6/17/96
11/15/96
1/9/97
3/8/97
3/10/97
3/15/97
9/17/97
Curriculum Vitae
Page 9
American Society of Hematology, National Meeting, Nashville, TN;
Educational Session: Peripheral Stem Cell Collection and Processing.
New Jersey Medical School, Newark, NJ, Department of Pathology,
“Autoreactivity and Lymphomagenesis”.
Blood Center of Southeastern Wisconsin, Milwaukee, WI, “Origin of
Autoimmune and Neoplastic B-Cells”.
New York University, New York, NY, Department of Hematology
Oncology, “Immunoglobulin Gene Analysis in Normal, Autoimmune and
Neoplastic B Cells”.
Oxford Forum, Oxford, UK, “Perspectives of Idiotypic Vaccines in B
CLL”.
Institut Pasteur, Division of Immunology, Paris, France. "Is
Immunoglobulin Gene Expression in Humans a Stochastic Process?".
NATO Conference on B-cells in Development and Disease, Luteren, The
Netherlands, "Expression of the VH4-34 Gene in Normal, Autoimmune
and Neoplastic Repertoires".
Chair, Annual Seminar: "Functional and Molecular Aspects of Blood
Group Antigens". American Association of Blood Banks, New Orleans,
LA.
Moderator, Plenary Session, American Association of Blood Banks, New
Orleans, LA.
Chairman, Scientific Subcommittee on Transfusion Medicine, American
Society of Hematology, Seattle, WA.
NIH Scientific Review Panel, “Adhesion Molecules in Transfusion
Medicine”, Bethesda, MD.
Blood Research Institute, Blood Center of Southeastern Wisconsin, “Ig
Gene Expression in Human B-cell Development”, Milwaukee, WI.
NIH, Heart, Lung and Blood Program Project Review Committee,
“Cellular Therapies in Transfusion Medicine”, Bethesda, MD.
Blood Center Research Foundation External Review, Blood Center
Research Institute, Milwaukee, WI.
St. Christopher’s Hospital for Children, “Pathophysiology of Autoimmune
Hemolytic Anemia”, Philadelphia, PA.
Temple University School of Medicine, Clinical Pathology Conference,
Department of Medicine.
National Cancer Institute, “HIV Induced B Cell Activation and
Lymphomagenesis”, Rockville MD.
Emory University Hospital, “AIDS Related Lymphoma: B-cell Activation
Preceding Lymphomagenesis”, Atlanta, GA. Visiting Professor, Dept. of
Pathology and Laboratory Medicine.
National Blood Foundation Grants Review Committee, Bethesda, MD
The Johns Hopkins University, “HIV Induced B Cell Activation and
Lymphomagenesis”, Baltimore, MD. Visiting Professor, Dept. of
Pathology and Laboratory Medicine.
Leslie Eric Silberstein, M.D.
9/21/97
9/29/97
10/19/97
11/25/97
12/8/97
4/2/98
4/19/98
6/1/98
6/13/98
9/16-17/98
12/5-6/98
1/19/99
5/22-29/99
9/22-23/99
10/12/99
11/8/99
Curriculum Vitae
Page 10
Harvard Medical School, Cancer Medicine and Hematology,
“Autoimmune Hemolytic Anemias”, Boston, MA.
National Institutes of Health, National Heart, Lung and Blood Institute,
Special Emphasis Panel Meeting, Research Priorities in Blood Diseases
and Resources, Bethesda, MD.
Chair, Short topic seminar: “Novel Cellular Therapies”, American
Association of Blood Banks Annual Meeting, Denver, Co.
Children’s Hospital of Pennsylvania, “Immunoglobulin Mediated
Mechanisms in B-Cell Development: Implications for Autoimmunity and
Lymphomagenesis”, Philadelphia, Pa.
Moderator, “Transfusion Medicine Session”, ASH Conference, American
Society of Hematology, San Diego, CA
University of Miami School of Medicine, Department of Pathology, “HIV
induced B-cell activation and lymphoma development”, Miami, FL.
“Role of Superantigen in Lymphomagenesis and Clonal evolution”, BCell Lymphoproliferative Disorders Conference, Imidex USA, Inc., New
York, NY.
University of California, Los Angeles, Department of Pathology and
Laboratory Medicine, Grand Rounds, “HIV induced B-cell activation and
lymphoma development”, Los Angeles, CA. Visiting Professor, Dept. of
Pathology and Laboratory Medicine.
“ Role of human VH genes in normal and neoplastic B cell development”,
ACPLS Conference, Boston MA
National Heart Lung and Blood Institute, Chair, “Research in Transfusion
Medicine”, Bethesda, MD
October 12, 1998. Workshop: B Cell Regulation, “Chemokine Receptors
and B-cell Activation”, European Research Conferences, Research
Conference of B Cells in Health and Disease: B Cells and Autoimmunity,
Maratea, Italy
"Immunomodulation in Leukoreduced Blood Components";
Transfusion Medicine Educational Symposium, American Society of
Hematology, Miami Beach, Florida
Keystone Symposia, “Role of Chemokines in Human B Cell
Development,” Silverthorne, CO.
Visiting Professor, Department of Pathology and Laboratory Medicine at
Albert Einstein Medical Center, New York, NY.
Coordinator and Chair for Alloimmunization Panel at AABB Scientific
Think Tank: “Setting the Research Agenda for Immunolobiology in
Transfusion Medicine,” Ellicott City, MD.
“Role of Chemokines in Human B Lymphopoieses,” The Richard and
Nancy Leeds Seminars in Experimental Immunology, North Shore
University Hospital, Manhasset, NY.
“Role of Chemokines in Human B Cell Development,” Children’s
Hospital Oakland Research Institute (CHORI), Oakland, CA.
Leslie Eric Silberstein, M.D.
11/5/00
12/3/00
5/9/01
6/01
10/13-14/01
10/16-22/01
4/2-7/02
12/17-18/02
2/11/03
3/13/03
3/24/03
3/9/04
4/14/05
6/24/05
1/6/06
Curriculum Vitae
Page 11
American Association of Blood Banks Annual Meeting, Meet the Expert
Session, Transfusion Medicine Expert
American Society of Hematology Annual Meeting, Meet the Expert
Session, Transfusion Medicine Expert
Bay State Medical Center, Update in Diagnostic Pathology and Medicine
Series 2000-2001
Cancer Research Institute, “Chemokine Mediated Adhesion in B
Lymphopoiesis”, Genoa, Italy
American Society of Blood Banks 54th Annual Meeting, “NBF Grants in
the Spotlight”, San Antonio Texas
Amsterdam Zoo 3rd Annual Meeting, “Sustained Versus Transient SDF-1
Induced Adhesion During B Call Development”, Amsterdam, Netherlands
Centro Nacional de Biotecnoloie (CNB), “B Linage Stage Determines
Prolonged Versus Transient Adhesion through Distinct Chemokine
Signaling Pathways”, Madrid, Spain
“Sustained Activation of Cell Adhesion in a Differentially Regulated
Process in B Lymphopoiesis,” University of Illinois, Chicago, IL.
“Sustained Chemokine-Induced Cell Adhesion is a Differentially
Regulated Process in B Lymphopoiesis,” University of Louisville,
Louisville, KY
“Sustained Activation of Cell Adhesion is a Differentially Regulated
Process in B Lymphopoiesis,” New York Blood Center, NY
“Chemokine Induced Adhesion in B Cell Development,” Yale Cancer
Center Grand Rounds, Yale University, CT
“Biology of Chemokine Mediated Adhesion During B Lymphopoiesis“
College of Physicians and Surgeons of Columbia University, New York
“The Role of Chemokines in the Bone Marrow Compartment” Montefiore
Medical Center, The University Hospital for the Albert Einstein College
of Medicine, New York
American Society of Hematology (ASH) Representative at the
International Society for Cellular Therapy (ISCT) Liaison Meeting,
Bethesda, MD
“Lymphocyte Activation and Signaling” Keystone Symposia, Steamboat
Springs, CO
5/07/06
“Targets and Delivery for Immunotherapy”- International Society for
Cellular Therapy, Berlin, Germany
12/10/06
Meet the Experts Session – American Society of Hematology Annual
Meeting, Orlando, FL
8/22/07
CELLutions Summit – Presentation: “Challenges of Translational Cell
Therapy.” World Trade Center, Boston, MA
Leslie Eric Silberstein, M.D.
10/20/07
Curriculum Vitae
Page 12
American Association of Blood Banks (AABB) Annual Meeting.
Director/Moderator of session 5122-S-CT, Molecular Mechanisms in
Stem Cell Therapy. Anaheim, CA
Bibliography:
Original Papers
1.
Schoenfeld, Y.S., Hsu-Lin, S.C., Gabriels, J.E., Silberstein, L.E., Furie, B. C., Furie, B.,
Stollar, B.D., Schwartz, R.S. Production of autoantibodies by human-human
hybridomas. Journal Clinical Investigation, 70(2):205-208, 1982.
2.
Silberstein, L.E., Berkman, E.M., Fanburg, B.L. Serum angiotensin-1-converting
enzyme after plasma exchange. Proceedings Society Experimental
Medicine,173:222,1983.
3.
Silberstein, L.E. and Berkman, E.M. Plasma exchange in autoimmune hemolytic anemia.
Journal Clinical Apheresis, 1 (4):238, 1984.
4.
Sherman, L.A., Silberstein, L.E., Berkman, E.M. Altered expression and
thrombocytopenia responsive to plasma infusion in a patient with congenital rubella.
Transfusion, 24:267-270, 1984.
5.
Silberstein, L.E., Schoenfeld, Y., Schwartz, R.S., Berkman, E.M. A Combination of IgG
and IgM autoantibodies in chronic cold agglutinin disease: immunologic studies and
response to splenectomy. Vox Sanguinis, 48:105-109, 1985.
6.
Silberstein, L.E., Duggan, D., Berkman, E.M. Plasma exchange in osteosclerotic
myeloma associated with the POEMS syndrome. Journal Clinical Apheresis, 2:253,1985.
7.
Silberstein, L.E. and Shaw, L. The effect of plasma exchange on phenytoin plasma
concentration. Therapeutic Drug Monitor, 8:172-176, 1986.
8.
Levine, S.B., Kimmelman, C.P., Zwillenberg, S., Silberstein, L. Blood transfusions in
surgery of the larynx and neck. Laryngoscope, 96(10):1095, 1986.
9.
Silberstein, L.E., Naryshkin, S., Haddad, J., Strauss, J.F. III. Calcium homeostasis during
plasma exchange. Transfusion, 26:151, 1986.
10.
Silberstein, L.E., Robertson, G.A., Hannam-Harris, A.C., Moreau, L., Besa, E., Nowell,
P.C. Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined
clones of lymphoid cells and the demonstration that an anti Pr cold autoantibody is
derived from a chromosomally aberrant B-cell clone. Blood, 67(6):1705-1709, 1986.
11.
Cameron, P., Limjuco, G., Chin, Y., Silberstein, L.E., Schmidt, J.A. Purification of the
pI 5.1 and pI 5.4 species of human IL-1. Journal Experimental Medicine, 164:237-250,
1986.
12.
Lichtin, A.E., Silberstein, L.E., Schreiber, A.D. Thrombotic thrombocytopenic purpura
with colitis in an elderly woman. JAMA, 255:11, 1986.
13.
Silberstein, L.E., Berkman, E.M., Schreiber, A.D. Cold hemagglutinin disease associated
with IgG cold reactive antibody. Annals of Internal Medicine, 106:238-242, 1987.
14.
Silberstein, L.E., Abrahm, J., Shattil, S.J. Intensive plasma exchange is an effective
therapeutic modality in acquired von Willebrand's disease. Transfusion, 27:234-237,
1987.
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Silberstein, L.E. and Spitalnik, S. Autoantibodies to erythrocytes. Clinical Immunology
Newsletter, 8(12) 177-188, 1987.
Lichtin, A.E., Schreiber, A.D., Hurwitz, S., and Silberstein, L.E. Efficacy of intensive
plasmapheresis in thrombotic thrombocytopenic purpura. Archives of Internal Medicine,
147:2122-2126, 1987.
Silberstein, L.E., Williams, L., Magee, D., Hughlett, M., and Weisman, R. An
autologous fibrinogen based adhesive for use in otologic surgery. Transfusion, 28:319321, 1988.
Andrzejewski, C., Gault, E., Briggs, M., and Silberstein, L.E. The benefit of a 37oC
extracorporeal circuit in plasma exchange therapy for selected cases with cold agglutinin
disease. Journal of Clinical Apheresis, 4:13-17, 1988.
Kruskall, M.S., Mintz, P.D., Bergin, J.J., Johnston, M.F.M., Klein, H., Miller, J.D.,
Rutman, R., Silberstein, L. Transfusion therapy in emergency medicine. Annals of
Emergency Medicine, 17:327-335, 1988.
Silberstein, L.E., Goldman, J., Kant, J.A., Spitalnik, S.L. Comparative biochemical and
genetic characterization of clonally related human B-cell lines secreting pathogenic anti
Pr2 cold agglutinins. Archives Biochemistry Biophysics, 264:244-252, 1988.
Andrzejewski, C., Young, P., Goldman, J., Spitalnik, S., Silberstein, L.E. Production of
human warm reacting anti-erythrocyte monoclonal autoantibodies by Epstein-Barr virus
transformation. Transfusion, 29:196-200, 1989.
Silberstein, L.E., Litwin, S., Carmack, C. Relationship of V genes expressed by a human
B-cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. Journal
Experimental Medicine, 169:1631-1643, 1989.
Silberstein, L.E., Kruskall, M.S., Stehling, L.C., et al., Strategies for the review of
transfusion practices. JAMA, 262:1993-1997, 1989.
Goodnough, L.T., Rudnick, S., Price, T.H., Ballas, S., Collins, M., Crowley, J., Kosmin,
M., Kruskall, M., Lenes, B., Menitove, J., Silberstein, L.E., Smith, K., Wallas, C., Von
Tress, M. Increased preoperative collection of autologous blood with recombinant
human erythropoietin therapy. New England Journal of Medicine, 321:1163-1168, 1989.
Silberstein, L.E., Jefferies, L.C., Goldman, J., Spitalnik, S.L. Production of
carbohydrate-specific human monoclonal antibodies in vitro. Methods in Enzymology,
179:299-304, 1989.
Judd, W.J., Luban, N.L.C., Ness, P.M., Silberstein, L.E., Stroup, M., Widmann, F.K.
Prenatal and perinatal immunohematology: recommendations for serologic management
of the fetus, newborn infant, and obstetric patient. Transfusion, 30:175-183, 1990.
Gordon, J., Silberstein, L.E., Moreau, L., Nowell, P.C. Trisomy 3 in cold agglutinin
disease. Cancer Genetics and Cytogenetics, 46:89-92, 1990.
Jefferies, L.C., Goldman, J., Bennett, I.M., Spitalnik, S.L., Silberstein, L.E. Antiidiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. Transfusion,
30:495-502, 1990.
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Goodnough, L. T., Johnston, M. F., Ramsey, G., Sayers, M.H., Eisenstadt, R.S.,
Anderson, K.C., Rutman, R.C., and Silberstein, L.E. Guidelines for transfusion support
in patients undergoing coronary artery bypass grafting. Annals of Thoracic Surgery,
50:675-683, 1990.
Andrzejewski, C., Young, P.J., Cines, D.B., Silberstein, L.E. Heterogeneity of Human
Anti-Erythrocyte autoantibodies assesed by isoelectric focusing. Transfusion, 31:236244, 1991.
Anderson, K.C., Goodnough, L.T., Sayers, M., Pisciotto, P.T., Kurtz, S.R., Lane, T.A.,
Anderson, C.S., Silberstein, L.E. Variation in blood component irradiation practice:
Implications for prevention of transfusion-associated graft-vs-host-disease. Blood,
77:2096-2102, 1991.
Friedman, D.F., Cho, E.A., Goldman, J., Carmack, C.E., Besa, E.C., Hardy, R.R.,
Silberstein, L.E. The role of clonal selection in the pathogenesis of an autoreactive
human B cell lymphoma. Journal of Experimental Medicine, 174:525-537, 1991.
Silberstein, L.E., Jefferies, L.C., Goldman, J., Friedman, D., Moore, J.S., Nowell, P.C.,
Roelcke, D., Pruzanski, W., Roudier, J., Silverman, G.J. Variable region gene analysis of
pathologic human autoantibodies to the related i and I red blood cell antigens. Blood,
78(9):2372-2386, 1991.
Reidl, L.S., Friedman, D.F., Goldman, J., Hardy, R.R., Jefferies, L.C., Silberstein, L.E.
Structural basis of a conserved idiotope expressed by an autoreactive human B-cell
lymphoma: Evidence that a VH CDR3 mutation alters idiotypy and specificity. Journal
of Immunology, 147(10):3623-3631, 1991.
Sayers, M.H., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Pisciotto, P.,
and Silberstein, L.E. Reducing the risk for transfusion-transmitted cytomegalovirus
infection. Annals of Internal Medicine, 116:1, 1992.
Grillot-Courvalin, C., Brouet, J.C., Piller, F., Rassenti, L.Z., Labaume, S., Silverman,
G.J., Silberstein, L.E., Kipps, T.J. An anti-B cell autoantibody from Wiskott-Aldrich
syndrome which recognizes i blood group specificity on normal human B cells.
European Journal of Immunology, 22:1781, 1992.
Lane, T.A., Anderson, K.C., Goodnough, L.T., Kurtz, S., Moroff, G., Pisciotto, P.T.,
Sayers, M., Silberstein, L.E. Leukocyte reduction in blood component therapy. Annals
of Internal Medicine, 117:2, 1992.
Stadtmauer, E.A., Edelstein, M., Lin, E., Spitalnik, S., Silberstein, L., Cassileth, P.A.
Autologous bone marrow transplantation with in vitro chemotherapy purge in first
remission chemotherapy of acute myeloid leukemia. Progress in Clinical and Biological
Research, 377:274-279, 1992.
Jefferies, L.C., Silverman, G.J., Carchidi, C.M., Silberstein, L.E. Idiotypic heterogeneity
of V III autoantibodies to the related i and I red blood cell antigens. Clinical
Immunology and Immunopathology, 65(2):119-128, 1992.
Friedman, D.F., Moore, J.S., Erikson, J., Manz, J., Goldman, J., Nowell, P.C., Silberstein,
L.E. Variable region gene analysis of an isotype switched (IgA) variant of chronic
lymphocytic leukemia. Blood, 80:2287-2297, 1992.
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Konrad, R.J., Krica, L.J., Goodman, D.B.P., Goldman, J, Silberstein, L.E. A myelomaassociated paraprotein in an HIV-1 seropositive patient directed against the HIV-1 p24
antigen. New England Journal of Medicine, 328:1817-1819, 1993.
Stevenson, F.K., Spellerberg, M.B., Treasure, J., Chapman, C.J., Silberstein, L.E.,
Hamblin, T.J., Jones, D.B. Differential usage of an Ig heavy chain variable region gene
by human B-cell tumors. Blood, 82:224-231, 1993.
Schutte, M.E.M., van Es, J.H., Silberstein, L.E., Logtenberg, T. VH4.21-encoded
autoantibodies with anti-i specificity mirror those associated with cold haemagglutinin
disease. Journal of Immunology, 151:6569-6576, 1993.
Goodnough, L.T., Anderson, K.C., Hurtz, S., Lane, T.A., Pisciotto, P.T., Sayers, M.H.,
Silberstein, L.E. Indications and guidelines for the use of hematopoietic growth factors.
Transfusion, 33:944-959, 1993.
Jefferies, L.C., Carchidi C.M., Silberstein, L.E. Naturally occurring anti-i/I cold
agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment.
Journal of Clinical Investigation, 92:2821-2833, 1993.
Siegel, D.L., Silberstein, L.E. Expression and characterization of recombinant antiRh(D) antibodies on filamentous phage: A model system for isolating human red cell
antibodies by repertoire cloning. Blood, 83:2334-2344, 1994.
Biggs, D.D., Stadtmauer, E., Mangan, P., Edelstein, M., Powlis, W., Buzby, G., Magee,
D., Sachs, B, Silberstein, L. 4-Hydroperoxycyclophosphamide purged autologous bone
marrow transplantation of relapsed, responding Non-Hodgkin's Lymphoma with
granulocyte colony stimulating factor support results in reliable hematopoietic recovery.
Progress in Clinical and Biological Research, in press, 1994.
Stadtmauer, E.A., Hodi, F.S., Sickles, C., Biggs, D.D., Mangan, P., Buzby, G., Zaleta, E.,
Silberstein, L.E. High-dose therapy and growth factor mobilized peripheral blood
progenitor cell support for responding patients with metastatic breast cancer. Advances
in Bone Marrow Purging and Processing: Fourth International Symposium, 487-495,
1994.
Biggs, D.D., Kraj, P., Goldman, J., Jefferies, L., Carchidi, C., Anderson, K. and
Silberstein, L.E. Immunoglobulin gene sequence analysis to further assess B-cell origin
of multiple myeloma. Clinical Diagnostic Immunology, 2:44-52, 1995.
Parr, T.B., Johnson, T.A., Silberstein, L.E., Kipps, T.J. Anti-B cell autoantibodies
encoded by VH4-21 genes in human fetal spleen do not require in vivo somatic selection.
European Journal of Immunology, 24:2941-2949, 1995.
Kraj, P., Friedman, D.F., Stevenson, F., Silberstein, L.E. Evidence for the
overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human
peripheral blood B cell repertoire. Journal of Immunology, 154:6406-6420, 1995.
Stadtmauer, E.A., Schneider, C.J., Silberstein, L.E. Peripheral blood progenitor cell
generation and harvesting. Seminars in Oncology, 22:291-300, 1995.
Stoerker, J., Hurwitz, C., Rose, N.C., Silberstein, L.E., Highsmith, W.W. Heteroduplex
generator in analysis of Rh blood group alleles. Clinical Chemistry, 42:356-360, 1996.
Przybylski, G.K., Goldman, J., Ng, V.L., McGrath, M.S., Herndier, B.G., Schenkein,
D.P., Monroe, J.G., Silberstein, L.E. Evidence for early B-cell activation preceding the
development of EBV-negative AIDS-related lymphoma. Blood, 88:4620-4629, 1996.
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Silberstein, L.E., George, A., Durdik, J.M., Kipps, T.J. The V4-34 encoded anti-i
autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells,
Molecules, and Diseases, 22:126-138, 1996.
Dighiero, G., Kipps, T., Schroeder, H.W., Chiorazzi, N., Stevenson, F., Silberstein, L.E.,
Caligaris-Cappio, F., Ferrarini, M. What is the CLL B-lymphocyte? Leukemia and
Lymphoma, 22:13-39, 1996.
Rose, N.C., Hurwitz, C., Silberstein, L., Andovalu, R., Stoerker, J. Prenatal analysis of
rhesus CcDEe blood groups by heteroduplex generator. American Journal Obstetrics and
Gynecology, 176:1084-1089, 1997.
Kraj, P., Rao, S.P., Glas, A.M., Hardy, R.R., Milner, E.C.B., Silberstein, L.E. The
human heavy chain immunoglobulin variable region gene repertoire is biased at all stages
of B cell ontogeny including early pre-B cell. Journal of Immunology, 158:5824-5832,
1998.
Shan, H., Goldman, J., Cunto, G., Manuppello, J., Chaiken, I., Cines, D.B., and
Silberstein, L.E.
Heterogenity of Anti-Phospholipid and Anti-Endothelial Cell
Antibodies. Journal of Autoimmunity, 11:651-660, 1998.
Westhoff, C.M., Schultze, A., From, A., Wylie, D., Silberstein, L.E. Characterization of
the Mouse Rh Blood Group Gene. Genomics, 57: 451-454, 1999.
Moore, H.C., Mick, R., Solin, L. J., Sickles, C., Mangan, P.A., Luger, S.M., Fox, K.R.,
Schuchter, L.M., Loh, E., Porter, D.L., Schuster, S., Buzby, G.P., Glatstein, E.,
Silberstein, L.E. and Stadtmauer, E.A.
Autologous stem-cell transplant after
conventional dose adjuvant chemotherapy for high-risk breast cancer: impact on the
delivery of local-regional radiation therapy. Annals of Oncology, 10: 929-936, 1999.
Rao, S.P., Riggs, J.M., Friedman, D.F., Scully, M., LeBien, T.W., Silberstein, L.E.
Biased VH gene usage in early lineage human B cells: Evidence for preferential
rearrangement in the absence of selection. Journal of Immunology, 163: 2732-40, 1999.
Honczarenko, M., Douglas, R.S., Mathias, C., Lee, B., Ratajczak, M.Z., and Silberstein,
L.E.
SDF-1 responsiveness does not correlate with CXCR4 expression levels of
developing human bone marrow B cells. Blood, 94:2990-2998, 1999.
Majka, M., Rozmyslowicz, T., Lee, B., Murphy, S.L., Pietrzkowski, Z., Gaulton, G.N.,
Silberstein, L.E., Ratajczak. M.Z. Bone Marrow CD34+ Cells and Megakaryoblasts
-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV.
Journal of Clinical Investigation, 104:1739-1749, 1999.
Cunto, G., Honczarenko, M., Przybilski, G., Monroe, J. and Silberstein, L..E. Evidence
that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIVrelated antigens. Blood, 95:1393-1399, 2000.
Majka, M., Ratajczak, J., Lee, B., Honczarenko, M., Douglas, R., Kowalska, M.A.,
Silberstein, L.E., Gewirtz, A.M., Ratajczak, M.Z. The role of HIV related Chemokine
Receptors and Chemokines in Human Erythropoiesis in Vitro. Stem Cells, 18: 2000.
Silberstein, L.E., Toy P Research Opportunities in Transfusion Medicine. The Journal of
the American Medical Association, 285:5, 577-580, 2001.
Honczarenko, Marek, Le, Y., Glodek, A.M., Majka, M., Campbell, J.J., Ratajczak, M.Z.,
Silberstein, L.E. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced
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responses of progenitor B cells in human bone marrow through heterologous
desensitization of the CXCR4 chemokine receptor. Blood, 100:2321-2329, 2002.
Zubair, A., Silberstein, L.E., Ritz, J. Adult hematopoietic stem cell plasticity.
Transfusion. 42:1096-1101. 2002.
Glodek, Aleksandra M., Honczarenko, M., Le, Y., Campbell, J.J., Silberstein, L.E.
Sustained Activation of Cell Adhesion is a Differentially Regulated Process in B
Lymphopoiesis. Journal of Experimental Medicine, 197:4, 1-14, 2003.
Burger, M., Glodek, A., Hartmann, T., Schmitt-Graff, A., Silberstein, L.E., Fujii, N.,
Kipps, T., Burger, J. Functional Expression of CXCR4 (CD184) on Small-Cell Lung
Cancer Cells Mediates Migration, Integrin Activation, and Adhesion to Stromal Cells.
Oncogene, 22, 8093-8101, 2003.
Le, Y., Honczarenko, M., Glodek, A.M., Ho, D., Silberstein, L.E. CXC Chemokine
Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane
Domain is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells. Journal of
Immunology, 2582-2590, 2005.
Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W.,
Engelke, K., Xia, L., McEver, R.P., Koni, P.A., Silberstein, L.E., von Andrian, U.H.
Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T
Cells. Immunity, 22(2):259-270, 2005.
Honczarenko, M., Lu, B., Nicholson-Weller, A., Gerard, N.P., Silberstein, L.E., Gerard,
C. C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone
marrow hematopoietic cell migration to CXCL12. Leukemia. 2005; 19: 1682-1683.
Honczarenko, M., Ratajczak, M.Z., Nicholson-Weller, A., Silberstein, L.E. Complement
C3a Enhances CXCL12 (SDF-1)-Mediated Chemotaxis of Bone Marrow Hematopoietic
Cells Independently of C3a Receptor (C3aR). J. Immunology. 2005; 195:3698-3706.
Honczarenko, M., Le, Y., Swierkowski, M., Ghiran, I., Glodek, A., Silberstein, L.E.
Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional
Chemokine Receptors. Stem Cells. 2006. Apr. 24(4):1030-41. Epub Oct. 2005.
Honczarenko M, Glodek AM, Swierkowski M, Na IK, Silberstein LE. Developmental
stage-specific shift in responsiveness to chemokines during human B-cell development.
Exp. Hematol. 2006 Aug;34(8):1093-1100.
Zhu D, Hattori H, Jo H, Jia Y, Subramanian K, Loison F, You J, Le Y, Honczarenko M,
Silberstein L, Luo H. Deactivation of phosphatidylinositol 3,4,5-triphosphate/Akt
signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci USA. 2006 Oct
3;103(40):14836-14841.
Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE,
Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of
galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007
Mar;47(3):442-451.
Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y.
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad
Sci USA 2007 Jun 19;104(25):10494-9.
Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J,
Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for
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CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor
cells. Leukemia. 2007 Aug;21(8):1723-32.
Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A,
Hennighausen L, Silberstein LE. SOCS3 Protein Developmentally Regulates the
Chemokine Receptor CXCR4-FAK Signaling Pathway During B Lymphopoiesis.
Immunity. 2007 Nov;27(5):811-23.
Editorials, Reviews, Chapters:
1.
Berkman, E.M. and Silberstein, L.E. Hemodynamics of plasma exchange and its clinical
effects. Proc. Fourth Annual Apheresis Symposium "Current Concepts and Future
Trends," 1982.
2.
Silberstein, L.E and Cines, D.B. Autoimmune hemolytic anemia, IN: Conn's Current
Therapy, R.E. Rakel, ed., W.B. Saunders, 1985.
3.
Silberstein, L.E. Cold hemagglutinin disease, IN: Current Therapy in
Hematology/Oncology, eds. M.D. Brain & P.P Carbone; C.V. Mosby Co., Toronto, 1985.
4.
Silberstein, L.E., and Cines, D.B. Autoimmune hemolytic anemia, IN: Conn's Current
Therapy, R.E. Rakel, ed. W.B. Saunders, 1986.
5.
Ellison, N., Silberstein, L.E. Hemostasis in the perioperative period. IN: Advances in
Anesthesia, ed. Stoelting, R.K. Vol. 3, 1986.
6.
White, K.W., and Silberstein, L.E. Quality Control in the Blood Bank, IN: Clinics in
Laboratory Medicine.
7.
Spitalnik, S.L., Andrzejewski, C., Goldman, J., Williams, L.J., Silberstein, L.E.
Biochemical and molecular studies of human autoantibodies to erythrocytes. IN: The
First International Workshop. Monoclonal Antibodies Against Human Red Blood Cells
and Related Antigens, eds. Peter Rouger, D. Anstee, and C. Salmon, Paris, 1988.
8.
Silberstein, L.E. and Rutman, R. Out-of-Hospital Transfusions. American Association of
Blood Banks, Arlington, VA 1989.
9.
Silberstein, L.E. Quality Assurance for Out-of-Hospital Transfusion Programs, IN:
Improving Transfusion Practice: The Role of Quality Assurance, eds. SS.R. Kurtz, S.
Summers, Kruskall, M.S.; American Association of Blood Banks, 1989.
10. Ellison, N. and Silberstein, L.E. A Commentary on Three Consensus Development
Conferences on Transfusion Medicine, IN: Anesthesiology Clinics of North America,
Bruce D. Spiess, M.D., Guest Editor, W. B. Saunders, 1990.
11. Silberstein, L.E., and Spitalnik, S.L. Blood Group Antigens and Antibodies, IN:
Principles of Transfusion Medicine, eds. Rossi, E.C., Simon, T.L., Moss, G S., Williams
and Wilkins, 1991.
12. Silberstein, L.E., and Spitalnik, S.L. Human Blood Group Antigens and Antibodies, IN:
Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil, S.J.,
Furie, B., and Cohen, H.J., Churchill Livingstone, 1991.
13. Schwartz, R.S., Berkman, E.M., Silberstein, L.E. The Autoimmune Hemolytic Anemias,
IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil,
S.J., Furie, B., and Cohen, H.J., Churchill Livingstone, 1991.
14. Siegel, D.L., Silberstein, L.E. Acquired Hemolytic Anemia. IN: Conn's Current Therapy,
R.B. Conn, ed. W.B. Saunders, 1991.
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Eshleman, J.R., and Silberstein, L.E. The Development of Selective Plasmapheresis as a
Means for Specific Therapeutic Intervention. Transfusion 31:96, 1991
Stevenson, F.K., Spellerberg, M.B., Jefferies, L.C., Goldman, J., Hamblin, T.J., Pascual,
V., Capra, J.D., and Silberstein, L.E. Monoclonal gammopathies and autoimmunity. IN:
Topics in aging research in Europe, eds. J. Radkl and B. vanCamp. Eurage, 14, 1991.
Siegel, D.L. and Silberstein, L.E. Red Cell Antigen Specificities and Autoimmune
Hemolytic Anemias. IN: Protein Blood Group Antigens of the Human Red Cell,
Structure, Function and Clinical Significance. eds. Peter C. Agre and Jean-Pierre Cartron;
The Johns Hopkins University Press, Baltimore, MD, 1992.
Lane, T.A., Anderson, K.C., Goodnough, L.T., Kurtz, S., Moroff, G., Pisciotto, P.T.,
Sayers, M., Silberstein, L.E. Leukocyte Reduction in Blood Component Therapy. Annals
of Internal Medicine, 117:151-162, 1992.
Sayers, M.H., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Pisciotto, P.
Silberstein, L.E. Reducing the Risk for Transfusion-transmitted Cytomegalovirus
Infection. Annals of Internal Medicine, 116:55-62, 1992.
Siegel, D.L. and Silberstein, L.E. Structural Analyses of Red Blood Cell Antibodies. IN:
Immunobiology of Transfusion Medicine. eds. George Garratty; Marcel Dekker, New
York, NY, 1993.
Silberstein, L.E. Natural and Pathologic Human Autoimmune Responses to Carbohydrate
Antigens on Red Blood Cells. IN: Springer Seminars in Immunopathology. eds. Peter A.
Miescher and Hans L. Spiegelberg, Springer-Verlag, Heidelberg, Germany. 1993.
Pisciotto, P.T., Anderson, K.C., Goodnough, L.T., Kurtz, S.R., Lane, T.A., Sayers, M.H.,
Silberstein, L.E. Current Trends: Evolving Concepts in Transfusion Medicine. The Need
for Standardization of Cryoprecipitate-derived Fibrin Adhesive. Transfusion Science
14:291-294, 1993.
Silberstein, L.E. The Antibody Response to Antigen. IN: Nance ST, ed. Alloimmunity:
1993 and Beyond Bethesda, MD: American Association of Blood Banks, 2:25-47, 1993.
Silberstein, L.E., Jefferies, L.E. Complications of Transfusion in Surgical Patients. IN:
Perioperative Medicine, eds. David R. Goldman, Frank H. Brown, David M. Guarnieri.
McGraw-Hill, New York, NY, 1994.
Siegel, D.L. and Silberstein, L.E. Red Blood Cell Autoantibodies. IN: Scientific Basis of
Transfusion Medicine. Implications for Clinical Practice. eds. Kenneth C. Anderson and
Paul M. Ness. W.B Saunders, Philadelphia, PA, 1994.
Silberstein, L.E. B-Cell Origin of Cold Agglutinins. Advances in Experimental Medicine
and Biology. 347:193-205, 1994.
Biggs, D.D., Silberstein, L.E. Laboratory Aspects of Bone Marrow Transplantation:
Collection, Processing, and Storage of Hematopoietic Stem Cells. eds. Ronald S.
Weinstein, Anna R. Graham, Robert E. Anderson, et al; Advances in Pathology and
Laboratory Medicine. 7:389-407, 1994.
Schwartz, R.S., Berkman, E.M., Silberstein, L.E. The Autoimmune Hemolytic Anemias,
IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil,
S.J., Furie, B., and Cohen, H.J. and Silberstein, L.E., 2nd edition Churchill Livingstone,
1994.
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34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
Curriculum Vitae
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Monroe, J.G., Silberstein, L.E. HIV-Mediated B-Lymphocyte Activation and
Lymphomagenesis. Journal of Clinical Immunology. 15:61-68, 1995.
Moore, J.S., Friedman, D.F., Silberstein, L.E., Besa, E.C., Nowell, P.C. Clinical
Heterogeneity Reflects Biologic Diversity in Chronic Lymphocytic Leukemia, Critical
Reviews in Oncology/Hematology, 20:141-164, 1995.
Silberstein, L.E. Molecular and Functional Aspects of Blood Group Antigens, editor,
American Association of Blood Banks, 1995.
Casali, P. and Silberstein, L.E. Immunoglobulin Gene Expression in Development and
Disease, editors, Annals of the New York Academy of Sciences, New York, NY, 1995.
Friedman, D.F., Kraj, P., Silberstein, L.E. VH4.21 Expression in the Normal Human BCell Repertoire. IN: Immunoglobulin Gene Expression in Development and Disease.
eds. Casali, P. and Silberstein, L.E. Annals of the New York Academy of Sciences, New
York, NY, 1995.
Jefferies, L.C., Carchidi, C.M., Silberstein, L.E. Immunoglobulin Gene Use by Naturally
Occurring Cold Agglutinins. IN: Immunoglobulin Gene Expression in Development and
Disease. eds. Casali, P. and Silberstein, L.E. Annals of the New York Academy of
Sciences, New York, NY, 1995.
Stadtmauer, E.A., Schneider, C.J., Silberstein, L.E. Peripheral Blood Progenitor Cell
Generation and Harvesting. Seminars in Oncology, 22:291-300, 1995.
Silberstein, L.E., Jefferies, L.C. Placental Blood Banking - A New Frontier in Transfusion
Medicine. New England Journal of Medicine, 335:199-201, 1996.
Frattali, A.L., Silberstein, L.E., Spitalnik, S.L. Human Blood Group Antigens and
Antibodies. In Principles of Transfusion Medicine (Rossi, E.C., Simon, T.L., Moss, G.S.,
eds.). Second Edition. Williams & Wilkins, Baltimore, 67-87, 1996.
Silberstein, L.E. Autoimmune Disorders of Blood, editor, American Association of Blood
Banks, 1996.
Sloan, S. R. and Silberstein, L.E. Transfusion in the Face of Autoantibodies. IN: Red Cell
Transfusions, A Practical Guide, eds. Reid, M.E., and Nance, S.J., Humana Press, 1998.
Eder, A.F. and Silberstein, L.E. Placental Blood: Immunology, Transplantation and Gene
Therapy, In: Molecular Biology of B-cell and T-cell Development. John G. Monroe and
Ellen V. Rothenberg, eds. Humana Press.1998.
Klein HG, Dzik WH, Slichter SJ, Hillyer CD, Silberstein LE: Leukocyte-reduced blood
components: current status, in McArthur JR, Schecter GP, Schrier SL (eds). Hematology
1998: American Society of Hematology Education Program Book. The American Society
of Hematology, Washington, DC, pp 154-77, 1998.
Hillyer, C.D., Lankford, K.V., Roback, J.D., Gillespie, T.W. and Silberstein, L.E.
Transfusion of the HIV-seropositive patient: immunomodulation, viral reactivation, and
limiting exposure to EBV (HHV-4), CMV (HHV-5), and HHV-6, 7, and 8. Transfusion
Medicine Reviews, 13: 1-17, 1999.
Silberstein, L.E., Berkman, E.M., Schwartz, R.S. The Autoimmune Hemolytic Anemias,
IN: Hematology Basic Principles and Practice, eds. Hoffman, R., Benz, Jr., E.J., Shattil,
S.J., Furie, B., and Cohen, H.J. and Silberstein, L.E., 3rd edition Churchill Livingstone,
1999.
Leslie Eric Silberstein, M.D.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
Curriculum Vitae
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Hug, B. and Silberstein, L.E. Red Blood Cell Autoantibodies. IN: Scientific Basis of
Transfusion Medicine. Implications for Clinical Practice. 2nd edition, eds. Kenneth C.
Anderson and Paul M. Ness. W.B Saunders, Philadelphia, PA, 2000.
Ninos, J.M., and Silberstein, L.E. Therapeutic Use of Blood Components. IN: Conn’s
Current Therapy 2000. Ed. Robert E. Rakel. W.B. Saunders, Philadelphia, PA, 2000.
Honczarenko, M. and Silberstein, L.E. Chemokines, Chemokine Receptor and their Role
in B Cell Development. Clinical Immunology, Second Edition. Edited by R. Rich, T.
Fleisher, B. Kotzin, W. Shearer and H. Schroeder. Mosby, pp 13.1-13.14, 2001.
Hillyer, C.D., Hillyer, K.L., Srobl, F. J., Jefferies, L.C., and Silberstein, L.E., eds
Handbook of Transfusion Medicine. Academic Press, San Diego, CA, 2001.
Silberstein, L.E., Cunningham, M.J. Autoimmune Hemolytic Anemias, In: Blood Banking
and Transfusion Medicine, Basic Principles & Practice, eds Hillyer, C.D., Silberstein,
L.E., Ness, P.M., Anderson, K.C., Churchill Livingstone, 2003.
Benjamin, R.J., Friedman, D.F., Silberstein, L.E., Sloan, S.R., Webb, I. Transfusion
Medicine, In: Nathan and Oski’s Hematology of Infancy and Childhood, eds Nathan, D.G.,
Orkin, S.H., Look, A.T., Ginsberg, D., W.B. Saunders, Philadelphia, PA. 2003.
Sloan, S.R. and Silberstein, L.E. Transfusion Medicine. In: Clinical Hematology and
Oncology, Presentation, Diagnosis, and Treatment, eds. Furie, B., Cassileth, P. A., Atkins,
M. B., Mayer, R. J., Churchill Livingstone, 2003.
Campbell, J., Sloan, S., Silberstein, L.E., “Leukocyte Trafficking,” In: Hematology: Basic
Principles and Practice, 4th Edition. Eds. Hoffman et al., Elsevier, Churchill Livingstone,
Philadelphia, PA. 2005.
Cunningham, M., Silberstein, L.E., “Autoimmune Hemolytic Anemias,” In: Hematology:
Basic Principles and Practice, 4th Edition. Eds. Hoffman et al., Elsevier, Churchill
Livingstone, Philadelphia, PA. 2005.
Silberstein, L.E., Cunningham, M. “Autoimmune Hemolytic Anemias,” In: Blood
Banking and Transfusion Medicine: Basic Principles and Practice. 2nd Edition. Eds.
Hillyer et al. Elsevier, Churchill Livingstone, Philadelphia, PA. 2006.