Brain Lexicon Design Documented on 7/25/02: JN Purpose: The purpose of this study is to get brain activation signatures for both individual low-frequency nouns and verbs, as well as their combination into two-word sentences, for use in training up a neural network on the data. The neural network will be used to determine if individual words can be recognized via their brain signatures and whether sentences can be identified from their component words, among other things. Stimuli: Sixteen low-frequency nouns and eight low-frequency verbs were chosen for use in this study. Eight of the nouns were animate and eight were inanimate. All the verbs had a K-F written frequency of 10 or below. All verbs but one had only verb meanings (one had a secondary noun meaning). Design: This study was broken down into three phases. Phase One: Eight words (four nouns and four verbs) were chosen from the list of 24 words. They appeared on the screen for one second each and were separated from each other by a 14 second fixation (so they were presented 15 seconds apart, onset to onset). This was in order to get the full hemodynamic response for each word. Phase one consists of two cycles (so each word is presented twice). Each cycle was randomized. Participants’ task in Phase One was to note whether each word presented was a noun or a verb. 8 words x 2 cycles x 15 seconds = 240 seconds (4 min) Phase Two: All 24 words were presented in Phase Two, repeated six times each, in six separately randomized cycles (actually, the 16 nouns were randomized and the 8 verbs were inserted to fit the other experimental criteria). Each word appeared on the screen for a duration of one second and was followed by a blank screen that lasted two seconds before the next word appeared. There were no breaks between cycles. Participants’ task in Phase Two was to note whether each word presented was a noun or a verb. Also, 20 sentences, created by pairing nouns and verbs together to form true and false statements, were embedded in each cycle (3-4 sentences per cycle). These were intended not to be noticed. 24 words x 6 cycles x 3 seconds = 432 seconds (7 min 12 sec) Phase Three: In Phase Three, the 20 embedded sentences from Phase Two were presented as sentences. The two words of each sentence were presented one at a time, appearing on the screen for one second each. There was a two second blank screen between the noun and the verb and an eleven second fixation cross after the verb before the next sentence appeared. This was a surprise task that participants had not practiced. Instructions appeared on the screen directing them to note (via a button press) whether each sentence presented was true or false. There were 10 true sentences and 10 false sentences presented. 20 sentences x 1 cycle x 15 seconds = 300 seconds (5 min) Surprise Instructions = 25 seconds (.42 min) Fixations: Four fixation periods of 30 seconds each were presented as well. One was presented before Phase One, one after Phase One, one after Phase Two, and the final fixation after Phase Three. 4 fixations x 30 seconds = 120 seconds (2 min) Miscellaneous (Instructions) = 7.5 seconds (.13 min) Total Running Time (without Scope Pulses) = 1140.5 seconds (19 min .5 sec) **Subject Number 1279 ran through this version (called BLex) with the following problems: Time was miscalculated for the experiment because power was out at CMU and the time could not be checked with Scope Pulses. Also, Phase Three was typed in the Scan Control Room and not checked or edited before being run. The surprise instructions only appeared on the screen for 1 second, so the subject did not even know what to do with the sentence task. Alterations: 7/22/02: Fixations were dropped to 24sec. P2C6 was deleted and miscellaneous instructions were cut to 6.50sec. Even with these cuts, the expt was still too long for the scanner (timed with SP it was at 19m). P2 was not edited to replace the lost embedded sentences from C6. This version, run with Subject Number 1280, was called BLex5cycles. 7/25/02: Before Scan: Miscellaneous instructions were cut to 6s. Two sentences were deleted (saved 30s) from P3, and more surprise instructions were included (examples and rewording) that added 7s. This version, run with Subject Number 1281, was called BLex5cycles2. After Scan: P2C1-P2C5 were edited to include the lost sentences from the prior deletion of C6 and to make changes as per the two new deleted sentences. So now P2 has 18 embedded sentences (required some reworking of the word order in those cycles) and P3 has 18 sentences. Surprise instructions were edited and a picture of button boxes added. This version, first to be run on Subject Number 1282 (on 7/29/02), was called BLex. The original BLex was renamed as BLex-OLD. The new time breakdown is as follows: Phase One: 240s Phase Two: 360s Surprise Instructions: 42s Phase Three: 270s Fixations: 96s Misc Instructions: 6s Total Time (without Scope Pulses): 1014s (16 min 54 sec)