Sanjay S. Shete, Ph.D
PRESENT TITLE AND AFFILIATION
Primary Appointment
Associate Professor, Department of Epidemiology, Division of
OVP, Cancer Prevention and Population Sciences,
The University of Texas M. D. Anderson Cancer Center,
Houston, TX
Dual/Joint/Adjunct Appointment
Regular Member, Graduate School of Biomedical Sciences, The
University of Texas Health Science Center at Houston, Houston,
TX
Adjunct Associate Professor, Department of Statistics, Rice University, Houston,
TX
Adjunct Member of Graduate Faculty, Texas A&M University, College Station, TX
OFFICE ADDRESS
The University of Texas M. D. Anderson Cancer Center
Department of Epidemiology, Unit 1340
1155 Pressler Blvd
Unit Number: 1340
Houston, TX 77030
Room Number: CPB4.3628
Phone: (713) 745-2483
Email: sshete@mdanderson.org
EDUCATION
Degree-Granting Education
Shivaji University, Kolhapur, Maharashtra, India, BS, First Class honors with
distinction, 1987, Statistics
Shivaji University, Kolhapur, Maharashtra, India, MS, First class honors with
distinction, 1989, Statistics
Shivaji University, Kolhapur, Maharashtra, India, Master of Philosophy, Overall A
Grade, 1990, Statistics
Indian Statistical Institute, Calcutta, West Bengal, India, Research Scholar in
Statistics, 1993, Statistics
The University of Georgia, Athens, GA, PHD, GPA 4.0/4.0, 1998, Statistics
Postgraduate Training
Research Associate, Genetic Epidemiology, Case Western Reserve University,
Cleveland, OH, 8/1998−3/2000
Continuing Education, Introduction to Genetics in Epidemiology, The University
of Michigan School of Public Health, Ann Arbor, MI, 2002−2002
Continuing Education, Analysis of Epidemiologic Data: An Applied Approach,
The University of Michigan School of Public Health, Ann Arbor, MI, 2002−2002
Continuing Education, Analysis of Clinical Trials, The University of Michigan
School of Public Health, Ann Arbor, MI, 2002−2002
Continuing Education, Advanced Gene Mapping/Linkage Course, The
Rockefeller University, New York, NY, 2002−2002
Continuing Education, Bayesian Biostatistics Short Course and Symposium, UT
M.D. Anderson Cancer Center, Houston, TX, 2003−2003
Continuing Education, Genomics in Biomedical Research: Principles and
Applications of Computational and Experimental Genomic Tools to Biomedical
Problems, Lawrence Berkeley National Laboratory, Berkeley, CA, 2004−2004
Continuing Education, Bayesian Analysis in Practice, American Statistical
Association, Salt Lake City, UT, 2007−2007
PUBLICATIONS
Peer-Reviewed Original Research Articles
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Shete S, Sriram TN. Fixed precision estimator of the offspring mean in branching
processes. Stochastic Processes and their Applications 77:17-33, 1998.
Shete S, Tiwari H, Elston RC. On estimating the heterozygosity and polymorphism
information content value. Theoretical Population Biology 57(3):265-271, 2000.
Kececioglu J, Shete S, Arnold J. Reconstructing distances in physical maps of
chromosomes with nonoverlapping probes. Proceedings of the International Conference on
Computational Molecular Biology (RECOMB):183-192, 2000.
Bhandarkar, SM, Machaka SA, Shete S, Arnold J. Parallel computation for chromosome
reconstruction on a cluster of workstations. International Parallel and Distributed
Processing symposium:63-70, 2000.
Shete S, Amos CI. A new test for linkage in affected sib pairs. GeneScreen 1:53-54, 2000.
Elston RC, Shete S. Adding power to Haseman and Elston’s (1972) method. GeneScreen
1:63-64, 2000.
Spitz MR, Wu X, Wang Y, Wang LE, Shete S, Amos CI, Guo Z, Lei L, Mohrenweiser H,
Wei Q. Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung
cancer patients. Cancer Research 61(4):1354-1357, 2001.
Bhandarkar SM, Machaka SA, Shete S, Kota RN. Parallel computation of a maximumlikelihood estimator of a physical map. Genetics 157(3):1021-1043, 2001.
Shete S, Chen J, Zhou X, Amos CI. Modeling age by major gene interaction by a variance
component approach. Genetic Epidemiology 21:S849-S853, 2001.
Guo D, Hasham S, Kuang SQ, Vaughan CJ, Boerwinkle E, Chen H, Abuelo D, Dietz HC,
Basson CT, Shete S, Milewicz DM. Familial thoracic aortic aneurysms and dissections:
genetic heterogeneity with a major locus mapping to 5q13-14. Circulation 103(20):24612468, 2001.
Amos CI, Shete S, Gu X. Variance components analysis for genetic linkage of time to
onset for disease. Genetic Epidemiology 21:S768-S773, 2001.
Bosken CH, Ko YC, Shete S, Wang TN, Chen J, Amos CI, Cheng LS. Modications in
linkage and association studies that improve the power in studies of complex traits.
Genetic Epidemiology 21:S89-S96, 2001.
Shete S, Amos CI, Hwang SJ, Strong LC. Individual-specific liability groups in genetic
linkage, with applications to kindreds with Li-Fraumeni syndrome. American Journal of
Human Genetics 70(3):813-817, 2002.
Qiao Y, Spitz MR, Shen H, Guo Z, Shete S, Hedayati M, Grossman L, Mohrenweiser H,
Wei Q. Comparison of two host-cell reactivation assays and their applicatin to molecular
epidemiology of DNA repair capacity. Carcinogenesis 23(2):295-299, 2002.
Shete S, Amos CI. Testing for genetic linkage in families by a variance-components
approach in the presence of genomic imprinting. American Journal of Human Genetics
70(3):751-757, 2002.
Wu X, Zhao H, Amos CI, Shete S, Makan N, Hong WK, Kadlubar FF, Spitz MR. Lung
Cancer susceptibility associated with p53 genotypes and haplotypes in various ethnic
groups. Journal of National Cancer Institute 94(9):681-690, 2002.
17. Fernandez JR, Etzel C, Beasley TM, Shete S, Amos CI, Allison DB. Improving the power
of sib pair quantitative trait loci detection by phenotype winsorization. Human Heredity
53(2):59-67, 2002.
18. Zheng Y, Shen H, Sturgis EM, Wang LE, Shete S, Spitz MR, Wei Q. Haplotypes of two
variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the
head and neck: a case-control study. Cancer Epidemiology, Biomarkers and Prevention
11(7):640-645, 2002.
19. Shete S, Sriram TN. Estimation theory for multitype branching processes with immigration.
Journal Sankhya Series A 65:107-121, 2003.
20. Shete S. A note on the optimal measure of allelic association. Annals of Human Genetics
67:189-191, 2003.
21. Shete S, Jacobs KB, Elston RC. Adding further power to the Haseman and Elston method
for detecting linkage in larger sibships: weighting sums and differences. Human Heredity
55:79-85, 2003.
22. Hasham SN, Willing MC, Guo DC, Muilenburg A, He R, Tran VT, Scherer SE, Shete S,
Milewicz DM. Mapping a locus for familial thoracic aortic aneurysms and dissections
(TAAD2) to 3p24-25. Circulation 107(25):3184-3190, 2003.
23. Etzel CJ, Shete S, Beasley TM, Fernandez JR, Allison DB, Amos CI. Effect of Box-Cox
transformation on power of Haseman-Elston and maximum-likelihood variance
components tests to detect quantitative trait Loci. Human Heredity 55:108-116, 2003.
24. Zeng Y, Shen, H, Sturgis EM, Wang L-E, Shete S, Spitz MR, Wei Q. Haplotypes of two
variants in p16 (CDKD2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the
head and neck-a case-control study: reply letter. Cancer Epidemiology, Biomarkers and
Prevention 12((1)):72-72, 2003.
25. Shete S. Uniformly minimum variance unbiased estimation of gene diversity. Journal of
Heredity 94(5):421-424, 2003.
26. Gorlova OY, Amos CI, Wang NW, Shete S, Turner ST, Boerwinkle E. Genetic linkage and
imprinting effects on body mass index in children and young adults. European Journal of
Human Genetics 11(6):425-432, 2003.
27. Shete S, Zhou X, Amos CI. Genomic imprinting and linkage test for quantitative-trait Loci in
extended pedigrees. American Journal of Human Genetics 73(4):933-938, 2003.
28. Wang Y, Spitz MR, Zhu Y, Dong Q, Shete S, Wu X. From genotype to phenotype:
correlating XRCC1 polymorphisms with mutagen sensitivity. DNA Repair 2(8):901-908,
2003.
29. Amos CI, Shete S, Chen J, Yu RK. Positional identification of microdeletions with genetic
markers. Human Heredity 56:107-118, 2003.
30. Liu E, Percy MJ, Amos CI, Guan Y, Shete S, Stockton DW, McMullin MF, Polyakova LA,
Ang SO, Pastore YD, Jedlickova K, Lappin TR, Gordeuk V, Prchal JT. The worldwide
distribution of the VHL 598C>T mutation indicates a single founding event. Blood
103(5):1937-1940, 2004.
31. Xu H, Wu X, Spitz MR, Shete S. Comparison of haplotype inference methods using
genotypic data from unrelated individuals. Human Heredity 58(2):63-68, 2004.
32. Strom SS, Gu Y, Zhang H, Troncoso P, Babaian RJ, Pettaway CA, Shete S, Spitz MR,
Logothetis CJ. Androgen receptor polymorphisms and risk of biochemical failure among
prostatectomy patients. The Prostate 60(4):343-351, 2004.
33. Meng S, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D,
Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D,
Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J, Uhr J. HER-2 gene
amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A
101(25):9393-9398, 2004.
34. Huang Q, Shete S, Amos CI. Ignoring linkage disequilibrium among tightly linked markers
induces false-positive evidence of linkage for affected sib pair analysis. American Journal
of Human Genetics 75(6):1106-1112, 2004.
35. Shete S, Beasley TM, Etzel CJ, Fernandez JR, Chen J, Allison DB, Amos CI. Effect of
winsorization on power and type 1 error of variance components and related methods of
QTL detection. Behavior Genetics 34(2):153-159, 2004.
36. Meng S, Tripathy D, Frenkel EP, Shete S, Naftalis EZ, Huth JF, Beitsch PD, Leitch M,
Hoover S, Euhus D, Haley B, Morrison L, Fleming TP, Herlyn D, Terstappen LW, Fehm T,
Tucker TF, Lane N, Wang J, Uhr JW. Circulating tumor cells in patients with breast cancer
dormancy. Clinical Cancer Research 10(24):8152-8162, 2004.
37. Xu H, Shete S. Effects of population structure on genetic association studies. BMC
Genetics 6:S109 (5 pages), 2005.
38. Neumann AS, Lyons HJ, Shen H, Liu Z, Shi Q, Sturgis EM, Shete S, Spitz MR, El-Naggar
A, Hong WK, Wei Q. Methylenetetrahydrofolate reductase polymorphisms and risk of
squamous cell carcinoma of the head and neck: a case-control analysis. International
Journal of Cancer 115(1):131-136, 2005.
39. Pannu H, Fadulu VT, Chang J, Lafont A, Hasham SN, Sparks E, Giampietro PF, Zaleski C,
Estrera AL, Safi HJ, Shete S, Willing MC, Raman CS, Milewicz DM. Mutations in
transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms
and dissections. Circulation 112(4):513-520, 2005.
40. Shete S, Yu R. Genetic imprinting analysis for alcoholism genes using variance
components approach. BMC Genetics 6:S161 (4 pages), 2005.
41. Xu H, Spitz MR, Amos CI, Shete S. Complex segregation analysis reveals a multigene
model for lung cancer. Human Genetics 116(1-2):121-127, 2005.
42. Wu CC, Shete S, Amos CI. Linkage analysis of affected sib pairs allowing for parent-oforigin effects. Annals of Human Genetics 69:113-126, 2005.
43. Yu R, Shete S. Analysis of alcoholism data using support vector machines. BMC Genetics
6:S136 (5 pages), 2005.
44. Bachinski LL, Olufemi SE, Zhou X, Wu CC, Yip L, Shete S, Lozano G, Amos CI, Strong
LC, Krahe R. Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to
human chromosome 1q23. Cancer Research 65(2):427-431, 2005.
45. Shete S, Zhou X. Parametric approach to genomic imprinting analysis with applications to
Angelman's syndrome. Human Heredity 59(1):26-33, 2005.
46. Huang Q, Shete S, Swartz M, Amos CI. Examining the effect of linkage disequilibrium on
multipoint linkage analysis. BMC Genetics 6:S83 (5 pages), 2005.
47. Pannu H, Kim DH, Seaman R, Van G, Shete S, Milewicz DM. Lack of an association
between the angiotensin-converting enzyme insertion/deletion polymorphism and
intracranial aneurysms in a Caucasian population in the United States. Journal of
Neurosurgery(103):92-96, 2005.
48. Wu CC, Shete S. Analysis of genes for alcoholism using two-disease-locus models. BMC
Genetics Suppl:S149 (4 pages), 2005.
49. Selvan MS, Ross MW, Nagaraj S, Etzel CJ, Shete S. Perception among upper middle
class adolescent in Bombay regarding sex and sexuality. Indian Journal of Public Health
49(4):250-251, 2005.
50. Wu CC, Shete S, Amos CI, Strong LC. Joint Effects of Germ-Line p53 Mutation and Sex
on Cancer Risk in Li-Fraumeni Syndrome. Cancer Research 66(16):8287-8292, 2006.
51. Pannu H, Kim DH, Guo D, King TM, Van Ginhoven G, Chin T, Chang K, Qi Y, Shete S,
Milewicz DM. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial
aneurysms. Journal of Neurosurgery 105(3):418-423, 2006.
52. Zhou X, Shete S. Linkage Analysis of Variation in Gene Expression Using a VarianceComponents Approach with Imprinting. Proceedings of the Genetic Analysis
Workshop(5):59-61, 2006.
53. Zaggar UA, Shete S, Kachroo S. Comparison of Multifactor Dimensionality Reduction
Techniques. Proceedings of the Genetic Analysis Workshop(6):73-74, 2006.
54. Tran-Fadulu V, Chen JH, Lemuth D, Neichoy BT, Yuan J, Gomes N, Sparks E, Kramer LA,
Guo D, Pannu H, Braverman AC, Shete S, Milewicz DM. Familial thoracic aortic
aneurysms and dissections: three families with early-onset ascending and descending
aortic dissections in women. American Journal of Medical Genetics 140(11):1196-1202,
2006.
55. Shete S, Zhou X. TLINKAGE-IMPRINT: a model-based approach to performing two-locus
genetic imprinting analysis. Human Heredity 62(3):145-156, 2006.
56. Lu J, Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F,
Hunt KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1
gene are associated with risk of sporadic breast cancer in non-Hispanic white women
<or=55 years. Carcinogenesis 27(11):2209-2216, 2006.
57. Wu CC, Chen W, Amos CI, Shete S. Two-Locus SNP Genome-Wide Scan in Caucasian
Families with Rheumatoid Arthritis. Proceedings of the Genetic Analysis Workshop(7):6770, 2006.
58. Shete S, Chen W, Swartz M, Zhou X, Lu Y, Yu R, Amos C, Wu CC. Joint linkage and
Imprinting analyses in Rheumatoid Arthritis Families. Proceedings of the Genetic Analysis
Workshop(10):53-55, 2006.
59. Meng S, Tripathy D, Shete S, Ashfaq R, Saboorian H, Haley B, Frenkel E, Euhus D, Leitch
M, Osborne C, Clifford E, Perkins S, Beitsch P, Khan A, Morrison L, Herlyn D, Terstappen
LW, Lane N, Wang J, Uhr J. uPAR and HER-2 gene status in individual breast cancer cells
from blood and tissues. Proc Natl Acad Sci U S A 103(46):17361-17365, 2006.
60. Lu J, Wei Q, Bondy ML, Yu TK, Li D, Brewster A, Shete S, Sahin A, Meric-Bernstam F,
Wang LE. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene
is associated with risk of sporadic breast cancer in non-Hispanic white women age younger
than 55 years. Cancer 107(9):2245-2253, 2006.
61. Xu H, Shete S. Mixed-effects logistic approach for association following linkage scan for
complex disorders. Annals of Human Genetics 71:230-237, 2007.
62. Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT,
Marian AJ. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy.
Circulation Research 100(6):766-768, 2007.
63. Spitz MR, Hong WK, Amos CI, Wu X, Schabath MB, Dong Q, Shete S, Etzel CJ. A risk
model for prediction of lung cancer. Journal of National Cancer Institute 99(9):715-726,
2007.
64. Chen WV, Amos CI, Etzel CJ, Shete S, Gregersen PK. Comparison of genome-wide
single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC
families. BMC Proc Suppl:S97, 2007.
65. Reyes-Gibby CC, Shete S, Rakvag T, Bhat SV, Skorpen F, Bruera E, Kaasa S, Klepstad
P. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain:
OPRM1 and COMT gene. Pain(130):25-30, 2007.
66. Yu R, Dehoff K, Amos CI, Shete S. Seeking gene relationships in gene expression data
using support vector machine regression. BMC Proc Suppl:S51, 2007.
67. Zhou X, Chen W, Swartz MD, Lu Y, Yu R, Amos CI, Wu CC, Shete S. Joint linkage and
imprinting analyses of GAW15 rheumatoid arthritis and gene expression data. BMC Proc
Suppl:S53, 2007.
68. Shete S, Elston RC, Lu Y. A novel approach to detect parent-of-origin effects from
pedigree data with application to Beckwith-Wiedemann syndrome. Annals of Human
Genetics 71:804-814, 2007.
69. Swartz MD, Shete S. The null distribution of stochastic search gene suggestion: a
Bayesian approach to gene mapping. BMC Proc Suppl:S113, 2007.
70. Wu CC, Grimson RC, Amos CI, Shete S. Statistical methods for anomalous discrete time
series based on minimum cell count. Biometrical Journal 50(1):86-96, 2008.
71. Gorlova OY, Lei L, Zhu D, Weng SF, Shete S, Zhang Y, Li WD, Price RA, Amos CI.
Imprinting detection by extending a regression-based QTL analysis method. Human
Genetics 122(2):159-174, 2007.
72. Daw EW, Chen SN, Czernuszewicz G, Lombardi R, Lu Y, Ma J, Roberts R, Shete S,
Marian AJ. Genome-wide mapping of modifier chromosomal loci for human hypertrophic
cardiomyopathy. Human and Molecular Genetics 16(20):2463-2471, 2007.
73. Reyes-Gibby CC, Spitz M, Wu X, Merriman K, Etzel C, Bruera E, Kurzrock R, Shete S.
Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308
G/A IL6-174G/C and IL8-251T/A. Cancer Epidemiology, Biomarkers and Prevention
16(12):2745-2751, 2007.
74. Guo DC, Pannu H, Tran-Fadulu V, Papke CL, Yu RK, Avidan N, Bourgeois S, Estrera AL,
Safi HJ, Sparks E, Amor D, Ades L, McConnell V, Willoughby CE, Abuelo D, Willing M,
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Lewis RA, Kim DH, Scherer S, Tung PP, Ahn C, Buja LM, Raman CS, Shete S, Milewicz
DM. Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms
and dissections. Nature Genetics 39(12):1488-1493, 2007.
Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F,
Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H,
Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE an
International Consortium to Understand Familial Glioma. Cancer Epidemiology Biomarkers
and Prevention 16(9):1730-1734, 2007.
Falk CT, Finch SJ, Kim W, Mukhopadhyay ND, Gong B, Hinrichs A, Li X, Liu X, Malhotra
A, Mehta T, Page G, Rao S, Saccone N, Shete S, Yang Y, Yu R, Zhao JH, Zhou X. Data
mining of RNA expression and DNA genotype data: presentation group 5 contributions to
Genetic Analysis Workshop 15. Genetic Epidemiology 31 Suppl:S43-50, 2007.
Ghosh S, Babron MC, Amos CI, Briollais L, Chen P, Chen WV, Chiu WF, Drigalenko E,
Etzel CJ, Hamshere ML, Holmans PA, Margaritte-Jeannin P, Lebrec JJ, Lin S, Lin WY,
Mandhyan DD, Nishchenko I, Schaid DJ, Seguardo R, Shete S, Taylor K, Tayo BO, Wan
S, Wei LY, Wu CO, Yang XR. Linkage analyses of rheumatoid arthritis and related
quantitative phenotypes: the GAW15 experience. Genetic Epidemiology 31 Suppl:S86-95,
2007.
Daw EW, Lu Y, Marian AJ, Shete S. Identifying Modifier Loci in Existing Genome Scan
Data. Annals of Human Genetics 72:670-675, 2008.
Reyes-Gibby C, Wu X, Spitz MR, Kurzrock R, Fisch M, Bruera E, Shete S. Molecular
Epidemiology, Cancer-related Symptoms, and Cytokines Pathway. Lancet
Oncology(8):777-785, 2008.
Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X,
Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV,
Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a
susceptibility locus for lung cancer at 15q25.1. Nature Genetics 40(5):616-622, 2008.
Wang J, Shete S. A test for genetic association that incorporates information about
deviation from Hardy-Weinberg proportions in cases. The American Journal of Human
Genetics 83(1):53-63, 2008.
Reyes-Gibby C, Osta B, Spitz MR, Parsons H, Kurzrock R, Wu X, Shete S, Bruera E. The
Influence of polymorphisms i cytokine genes on pain and response to analgesia in lung
cancer patients referred for Palliative Treatment: TNF-308 G/A, IL-6-174 G/c, and IL-8251T/A. Cancer Epidemiology Biomarkers and Prevention 17:3262-3267, 2008.
Wilkinson AV, Shete S, Vasedevan V, Prokhorov AV, Bondy ML, Spitz MR. The influence
of subjective social status on the relationship between positive outcome expectations and
experimentation with cigarettes. Journal of Adolescent Health. In Press.
Wang J, Shete S. Is the tail strength measure more powerful for genetic association test?
And Tail Strength to Combine Two P-values: Their Correlation Cannot Be Ignored: Authors
reply. The American Journal of Human Genetics. In Press.
Wilkinson AV, Shete S, Prokhorov AV. The moderating role of parental smoking on their
children's attitudes toward smoking among a predominantly minority sample: a crosssectional analysis. Substance Abuse Treatment, Prevention, and Policy 3(1):18, 2008.
Swartz, MD, Yu R, Shete S. Finding Factors Influencing Risk: Comparing Variable
Selection Methods Applied to Logistic Regression Models of Cases and Controls. Statistics
in Medicine 27:6158-6174, 2008