International Kidney and Monoclonal Gammopathy Research Group 2nd International Meeting La Rochelle, France, September 3-4, 2015 Dear Friends and Colleagues, We are particularly honored to invite you to the second international IKMG meeting in La Rochelle in September 2015. The goal of the IKMG is to promote the research and understanding of kidney diseases resulting from monoclonal gammopathies and we are very excited about the program our organizing committee has put together. Planned are state of the art lectures in pathology, diagnostics and treatment of monoclonal gammopathy related kidney diseases presented by experts from around the world. A poster and plenary session will cover the latest advances in this evolving field. This meeting will hopefully stimulate exchanges between clinicians and researchers, and open up new perspectives in the diagnostic and therapeutic approach of these rare disorders, through better understanding of their pathophysiological mechanisms. La Rochelle is a very pleasant city located on the west coast of France. The meeting will be held at the Espace Encan, close to the old port in the historical city center, with a wide choice of hotels within walking distance. The social program will be a unique opportunity to discover the best local food. Looking forward to meeting you in La Rochelle, Guy Touchard, Congress President Nelson Leung, IKMG President GENERAL INFORMATION Meeting address: Espace Encan, Quai Louis Prunier, BP 3106, 17033 La Rochelle, France. Online Registration and Hotel Reservation: http://reservation.larochelle-evenements.fr/event/registration?eventid=73&langue=UK Contact: Tiffany Barbier, La Rochelle Evenements, Quai Louis Prunier – BP 3106 17033 La Rochelle cedex 01, France. Tel : (33) 5 46 45 91 43. E-mail: www.larochelle-evenements.fr Registration fees (including lunchs and dinner on Thursday September 3rd): Seniors: 300 euros MD or PhD aged less than 35 years: 150 euros Trainees, PhD students: 50 euros The number of participants will be limited to 250. Registration will be closed on Wednesday August 26, 2015 Sponsors: PRELIMINARY PROGRAM Thursday, sept. 3 8:00 a.m. – 9:15 a.m. Introduction: Guy Touchard and Nelson Leung - The history of monoclonal gammopathies: Robert A. Kyle (Mayo Clinic, Rochester, USA) MGRS: an evolving concept: Nelson Leung (Mayo Clinic, Rochester, USA) - Classification of renal disorders in monoclonal gammopathies: Guy Touchard (University of Poitiers, France) - The kidney biopsy in MGRS: recent advances in pathology: Samih Nasr (Mayo Clinic, Rochester, USA) - Coffee break 9:30 a.m. – 12:30 a.m. Proximal Tubule in Monoclonal Gammopathy: From the microscope to the Lab - Light chain tubulopathy with crystals: Vivette D’Agati (Columbia University, New-York, USA) - LC proximal tubulopathy without crystals: Guillermo Herrera (Louisiana State University, Shreveport, USA) - LC-induced interstitial nephritis: Maria Picken (Loyola University Medical Center, Chicago, USA) - Inflammatory pathways involved in proximal tubular injury: Veichi Batuman (Tulane University, New Orleans, USA) - Panel discussion 2:00 p.m. – 3:00 p.m. Update on monoclonal protein detection/measurement - New free light chain assays: Ashu Wechalekar (National Amyloidosis Centre, London, UK) - Mass spectrometry: David Murray (Mayo Clinic, Rochester, USA) 3:00 p.m. – 4:15 p.m. New Renal response and emerging therapies in AL amyloidosis - Assessing renal response in AL amyloidosis: Giampaolo Merlini (University of Pavia, Italy) - Anti-SAP therapy: Julian Gillmore (National Amyloidosis Centre, London, UK) - Anti-fibril therapy: Brendan Weiss (University of Pennsylvania, Philadelphia, USA) - Coffee break 4:30 p.m. – 6:00 p.m. Update on the management of myeloma cast nephropathy - Chemotherapeutic options: Efstathios Kastritis (University of Athens, Athens, Greece) - Free light chain removal: Colin Hutchison (Hawke's Bay DHB, New Zealand) - Response measurement: Heinz Ludwig (Wilhelmine Hospital, Vienna, Austria) - Group discussion 6:00 p.m. Poster viewing and wine reception Friday, sept. 4 8:30 a.m. – 10:30 a.m. Update in pathophysiology: animal models - Cast nephropathy: Paul Sanders (University of Birmingham Alabama, Birmingham, USA) - LC Fanconi syndrome: mouse and cellular studies: Olivier Devuyst (University of Zurich, Zwitzerland) - AL amyloidosis: Guillermo Herrera (Louisiana State University, Shreveport, USA) - Randall-type MIDD: Christophe Sirac (University of Limoges, France) - Coffee break 10:45 a.m. – 12:00 a.m. C3 glomerulopathy and monoclonal gammopathy - C3 GP and monoclonal gammopathy: the disease spectrum: Frank Bridoux (University of Poitiers, France) - The complement system in C3GP and monoclonal gammopathy: Véronique FrémeauxBacchi (HEGP, Paris, France) 12:00 – 12:45: Extra-renal manifestations of monoclonal gammopathy: Jean Paul Fermand (Saint Louis University Hospital, Paris, France) 2:00 p.m. – 4:00 p.m. Oral communications 4:00 p.m. Closing remarks 4:30 p.m. – 5:30 p.m. IKMG board meeting