CURRICULUM VITAE
HANS-PETTER HERSLETH
Current status:
Personal data:
Post doctor
Department of Molecular Bioscience
University of Oslo, P.O. Box 1041 Blindern,
N-0316 Oslo, Norway
Phone +47 22855465, Fax +47 22855441
E-mail: h.p.hersleth@kjemi.uio.no
Born:
January 11, 1976, Norway.
Citizenship:
Norwegian
Civil status:
Single
Private address: Hersletveien 185, N-1850
Mysen, Norway
Phone:
+47 41333126
Education
1998
2000
2004
2007
Candidatus Magisterius, University of Oslo, Norway
Candidatus Scientiarum, Department of Chemistry, University of Oslo, Norway
Teacher Education Program, (one-year), Deparment of Teacher Education and School
Development, University of Oslo, Norway
Doctor Scientarum, Department of Chemistry, University of Oslo, Norway
Employment
2000-2006
2006-2007
2007
2007-
PhD Fellow with 40% teaching, Department of Chemistry, University of Oslo,
Temporary College lecturer (38% per week), Faculty of Engineering, Oslo
University College, Norway
Temporary lecturer and researcher (25% per week, january-august), Department of
Chemistry, University of Oslo, Norway
Post doc., Department of Molecular Bioscience, University of Oslo, Norway
Areas of Research Interest
Protein crystallography, X-ray diffraction, radiation damage, single-crystal light absorption,
metalloproteins, proteins, hydrogen bonds, hydrophobic interactions, radicals, EPR, resonance
Raman spectroscopy, crystal growth, solvates, crystallographic databases.
Other activities
Member of the Norwegian Chemistry Olympiad Committee under the Norwegian Chemical
Society since 2004.
Teaching Experience
(at University of Oslo)
2000 Autumn – General Chemistry (KJ100) - Exercises and laboratory assistant (40%)
2001 Spring – Plan work on the new chemistry course “Introduction to Chemistry” (40%)
2001 Autumn – Introduction to Chemistry (KJ050) - Exercises and laboratory assistant (40%)
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2002 Spring
2002 Autumn
2003 Spring
2004 Spring
2004 Autumn
2005 Spring
2005 Autumn
2006 Spring
2006 Autumn
2007 Spring
2007 Spring
– Protein Crystallography (KJ-KJB234) – Lectures (4h) and laboratory assistant (20%)
– Introduction to Chemistry (KJ050) - Exercises and laboratory assistant (40%)
– Protein Crystallography (KJ-KJB234) – Lectures (8h) and laboratory assistant (20%)
– Protein Crystallography (KJM5310) – Lectures (6h)
– Structure of Biological Macromolecules (KJM5310) – Lectures (30h), exercises (
---(12h) (course responsible) (corresponds to 40%)
– Protein Crystallography (KJM5300) – Lectures (15h), exercises (8h) and laboratory
– assistant (40h) (course responsible) (corresponds to 40%)
– Structure of Biological Macromolecules (KJM5310) – Lectures (30h), exercises -- --- (12h), (course responsible), (corresponds to 40%)
– Organic Chemistry I (KJM1011) – Laboratory assistant (corresponds to 40%)
– Pre-course in chemistry for Engineering students at the Oslo University College
(14 h per week including teaching and preparation)
– Structure of Biological Macromolecules (KJM5310) – Lectures (24h), exercises -- --- (12h)
– Pre-course in chemistry for Engineering students at the University College of Oslo
(14 h per week including teaching and preparation)
Long term visit
February 2001 – August 2001: Institute of Pharmacology and toxicology, Karl Franzens
Universität Graz, Austria.
Short term visit
Regularly colleting data at the synchrotrons mainly in Grenoble, but also in Hamburg and Lund
with 2-4 visits per year since 1999.
Awards
1999
2005
Norsk Hydro’s Price for Excellent Results in Chemistry (Cand. Mag. Degree), 1998-99.
Erice Poster Price 2005 for the most attractive poster at the 37th International School of
Crystallography “Evolving Methods in Macromolecular Crystallography”
List of articles
1.
2.
3.
4.
On the inclusion of solvent molecules in the crystal structure of organic compounds.
Görbitz, C. H. & Hersleth, H.-P. Acta Cryst. B56, 526-534 (2000).
Selective solvent inclusion as a tool for mapping molecular properties in crystal structures
- a diethylstilbestrol example.
Görbitz, C. H. & Hersleth, H.-P. Acta Cryst. B56, 1094-1102 (2000).
An iron hydroxide moiety in the 1.35 Å resolution structure of hydrogen peroxide derived
myoglobin compund II at pH 5.2.
Hersleth, H.-P., Dalhus, B., Görbitz, C. H. & Andersson, K. K. J. Biol. Inorg. Chem. 7,
299-304 (2002).
The Protonation Status of Compound II in Myoglobin, Studied by a Combination of
Experimental Data and Quantum Chemical Calculations: Quantum Refinement
Nilsson, K., Hersleth, H.-P., Rod, T.H., Andersson, K.K. & Ryde, U. Biophys. J., 87,
3437-3447 (2004).
2 of 6
5.
6.
Crystallographic and spectroscopical studies of peroxide-derived myoglobin compound II
and Occurence of protonated FeIV-O.
Hersleth, H.-P., Uchida, T., Røhr, Å. K., Teschner, T., Schünemann, V., Kitagawa, T.,
Trautwein, A. X., Görbitz, C. H. & Andersson, K. K. J. Biol. Chem., 280, 23372-23386
(2007).
The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of
myoglobin compound III during data collection.
Hersleth, H.-P., Hsiao, Y.-W., Ryde, U., Görbitz, C. H. & Andersson, K. K. Biochem. J.
412, 257-264 (2008)
List of review articles
1.
2.
3.
Structures of the high-valent metal-ion haem-oxygen intermediates in peroxidases,
oxygenases and catalases.
Hersleth, H.-P., Ryde, U., Rydberg, P., Görbitz, C.H. & Andersson, K.K. J. Inorg.
Biochem., 100, 460-476 (2006).
Reactive Complexes in Myoglobin and Nitric Oxide Synthase.
Hersleth, H.-P., Varnier, A., Harbitz, E, Røhr, Å. K., Schmidt, P. P., Sørlie,, M.,
Cederkvist, F. H., Marchal, S., Gorren, A. C. F., Mayer, B., Uchida, T., Schünemann, V.,
Kitagawa, T., Trautwein, A. X., Shimizu, T., Lange, R., Görbitz, C. H. & Andersson, K.
K. Inorg. Chim. Acta 361, 831-846 (2008).
The Influence of X-Rays on the Structural Studies of Peroxide-Derived Myoglobin
Intermediates.
Hersleth, H.-P., Hsiao, Y.-W., Ryde, U., Görbitz, C. H. & Andersson, K. K. Chem. Biodiv.
In press. (2008)
4.
Lectures
2000
2001
2002
2003
2003
2006
Iron-Oxygen Protein Network Meeting, 14th–15th April 2000, Gardermoen, Norway.
Crystal Structure at 1.45 Å of the Ferryl Myoglobin (Compound II Model).
Norwegian Synchrotron Research User Meeting, 18th–19th January 2001, Gardermoen,
Norway.
The Structure of the Myoglobin Compound II Intermediate Formed by Reaction with
Hydrogen Peroxide.
38th Norwegian Biochemical Society Contact Meeting, 17th–20th Jan 2002, Røros, Norway.
High Resolution Crystal Structure of Intermediates Formed In Myoglobin-Peroxide
reactions.
1st Meeting of the Protein Structure and Spectroscopy Subgroup of MedCoast
Scancdinavia, 14th-15th January 2003, Oslo, Norway.
Structural Studies of the Myoglobin-Peroxide Reaction.
2nd Swiss-Norwegian Beam Line Highlights meeting, 23th–25th Jun 2003, Tromsø, Norway.
Trapping reaction intermediates in the myoglobin-peroxide reaction. A crystallographic
study supported by single crystal light absorption spectroscopy.
2nd Meeting of the Protein Structure and Spectroscopy Subgroup of MedCoast
Scancdinavia, 25th-26th January 2006, Göteborg, Sweden.
The second function of myoglobin. A structural study of the intermediates in the reaction
between myoglobin and peroxides.
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2007
19th Nordic Structural Chemistry Meeting, 8th-11th January 2007, Spåtind, Norway.
Combining protein crystallography and single crystal light absorption spectroscopy –
Structures of intermediates in the reaction between myoglobin and peroxides.
Posters with published abstracts
2001
2001
2002
2002
2004
2005
2005
2005
17th Nordic Structural Chemistry Meeting, 7th–10th January 2001, Aarhus, Denmark.
The Structure of the Myoglobin Compound II Intermediate Formed by Reaction with
Hydrogen Peroxide.
Hersleth, H.-P., Dalhus, B., Görbitz, C. H. & Andersson, K.K., P14.
10th International Conference on Bioinorganic Chemistry, 26th–31th August 2001,
Florence, Italy.
Compound II in Peroxidases: New Resonance Forms Suggested by pH Dependent
Structures of Intermediates Formed in Myoglobin-Peroxide Reactions.
Hersleth, H.-P., Dalhus, B., Görbitz, C. H. & Andersson, K. K. J. Inorg. Biochem. 86,
260-260 (2001).
6th European Conference on Biological Inorganic Chemistry, 29th July – 3th August 2002,
Lund, Sweden and Copenhagen, Denmark.
Crystallographic and Spectroscopical Studies of Peroxide-Derived Myoglobin Compound
II.
Hersleth, H.-P., Uchida, T., Teschner, T., Shünemann, V., Görbitz, C. H., Kitagawa, T.,
Trautwein, A. X. & Andersson, K. K., P180, 256
XIX Congress and General Assembly of the International Union of Crystallography, 6th–
15th August 2002, Geneva, Switzerland.
pH Dependence of Peroxide Derived High Valent Haem in Myoglobin Studied by X-Ray
Crystallography.
Hersleth, H.-P., Dalhus, B., Görbitz, C. H. & Andersson, K. K. Acta Cryst. A58
(Supplement), C117 (2002).
7th European Conference on Biological Inorganic Chemistry, 29th August – 2nd September
2004, Garmisch-Partenkirchen, Germany.
Intermediates of the myoglobin-peroxide reaction – A structural investigation
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K., P106, 171
3rd Norwegian User Meeting – Application of Synchrotron Radiation, 10th – 11th March
2005, Trondheim, Norway.
Combination of protein crystallography and microspectrophotometry. Trapping
intermediates in the myoglobin-peroxide reaction cycle
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K.,
37th International School of Crystallography: Evolving methods in macromolecular
crystallography, 12th –22nd May 2005, Erice (Sicilia), Italia.
Structural Studies of the intermediates in the myoglobin-peroxide reaction
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K., P18, 198
XX Congress and General Assembly of the International Union of Crystallography, 23rd–
31st August 2005, Florence, Italy
Structure of the intermediates in the myoglobin-peroxide reaction..
4 of 6
2006
2006
2006
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K., Acta Cryst. A61, C214 (2005).
38th International School of Crystallography: The Structure and Function of Large
Molecular Assemblies, 9th –18th June 2006, Erice (Sicilia), Italia.
Structural Studies of intermediates in the reaction between myoglobin and peroxides.
Hersleth, H.-P., Uchida, T., Røhr, Å. K., Teschner, T., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K.
8th European Conference on Biological Inorganic Chemistry, 2nd – 6th July 2006, Aveiro,
Portugal.
Structural studies of intermediates in the myoglobin-peroxide reaction.
Hersleth, H.-P., Uchida, Røhr, Å. K., T., Teschner, T., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K.
Peroxidase 2006 meeting 6th–9th July 2006, Aveiro, Portugal.
Structures of intermediates in the myoglobin-peroxide reaction.
Hersleth, H.-P., Uchida, Røhr, Å. K., T., Teschner, T., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T., & Andersson,
K. K.
Workshops
2001
2002
2002
2003
2005
2006
Application of Synchrotron Radiation in Chemsitry, Biology and Physics – NorFA
Research Training Course, 24th June –1st July 2001, Sønderborg, Denmark.
Nordic Summer School in Synchrotron Radiation Research, 3rd –11th June 2002,
Smygehus/Lund, Sweden.
MedCoast Workshop on Expression & Structural Studies of Membrane Proteins, 28th –29th
October 2002, Göteborg, Sweden.
Current Trends in Structure-Aided Drug Design Workshop, 22nd –24th May 2003, Lund,
Sweden.
37th International School of Crystallography: Evolving methods in macromolecular
crystallography, 12th –22nd May 2005, Erice (Sicilia), Italia.
38th International School of Crystallography: The Structure and Function of Large
Molecular Assemblies, 9th –18th June 2006, Erice (Sicilia), Italia.
Abstracts
2001
37th Norwegian Biochemical Society Contact Meeting, 18th–21th Jan 2001, Beito, Norway
High Resolution Structures of a Model for Compound II in Peroxidases Obtained From
Hydrogen Peroxide Incubation with Myoglobin at Different pH.
Hersleth, H.-P., Dalhus, B., Görbitz, C. H. & Andersson, K.K., SF4.
2005
15th IUPAB & 5th EBSA International Biophysics Congress, 27th August – 1st September
2005, Montpellier, France.
High resolution crystal structures of two of the intermediates in the peroxide reaction of
myoglobin.
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
5 of 6
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T. & Andersson, K.
K., . Eur. Biophys. J. 34, 661 (2005)
2005
11th International Conference on Bioinorganic Chemistry, 31th July – 5th August 2005,
Ann Arbor, USA.
High resolution crystal structures of two of the intermediates in the myoglobin peroxide
reaction.
Hersleth, H.-P., Uchida, T., Teschner, T., Røhr, Å. K., Schünemann, V., Nilsson, K.,
Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Görbitz, C. H., Kitagawa, T. & Andersson, K.
K., .
2006
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th
FAOBMB Congress, 18th–23rd June 2006, Kyoto, Japan.
Crystallographic and spectroscopic studies of two of the intermediates in the myoglobinperoxide reaction.
Andersson, K. K., Hersleth, H.-P., Uchida, T., Røhr, Å. K., Teschner, T., Schünemann, V.,
Nilsson, K., Hsiao, Ya-wen, Trautwein, A. X., Ryde, U., Kitagawa, T. &. Görbitz, C. H.
Other chemistry related articles and lectures
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The chemistry olympiad 2004.
Hersleth, H.-P. KJEMI (publication of the Norwegian Chemical Society). 7, 18 (2004).
Norwegian chemistry olympiad finale.
Hersleth, H.-P. KJEMI (publication of the Norwegian Chemical Society). 2, 12-13 (2005).
Norwegian finale in the chemistry olympiad 2006.
Hersleth, H.-P. & Dalhus, B. KJEMI (publication of the Norwegian Chemical Society). 4,
20-21 (2006).
The chemistry olympiad.
Dalhus, B., Hersleth, H.-P. Jacobsen, Ø. Lecture at the “Day of educational science” at
University of Oslo (2006).
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