THE CYPRUS INSTITUTE OF NEUROLOGY & GENETICS Electron Microscopy/Molecular Pathology Department P.O. Box 23462 1683 Nicosia, Cyprus Tel.: (+357) 22 392 631 (+357) 22 358 600 Fax: (+357) 22 392 641 E-mail: kyriacos@cing.ac.cy Website: www.cing.ac.cy November 23, 2009 To the Editor, I am enclosing a manuscript titled “Epidemiology of breast cancer in Cyprus: a population based case control study” to be considered for publication in BMC Cancer. This manuscript has not been submitted elsewhere for publication. This study presents the first report, for breast cancer risk factors in Cypriot women, and provides the first scientific evidence for more targeted campaigns of prevention and early diagnosis, in our population. In addition, this investigation provides important background information, for designing more detailed studies that aim to improve our understanding of the epidemiology of breast cancer in the Cypriot population. I appreciate your consideration of this manuscript for publication and look forward to hearing from you. Sincerely yours, Kyriacos Kyriacou, PhD Senior Scientist, Head of the Department of EM/Molecular Pathology