Curriculum Vita NAME: Karen Sue Pawlowski, PhD 3393 County Road 324 McKinney, TX 75069 karen.pawlowski@utsouthwestern.edu 214-648-2574 office, 214-648-7280 lab MAIDEN NAME: Robinson EDUCATION: 2000 Ph. D. Program in Human Development and Communication Sciences, University of Texas at Dallas, Richardson, Texas. 1997 M.S. Applied Cognition and Neuroscience, University of Texas at Dallas, Richardson, Texas. 1981 B.S. Biology, College of Biological Sciences, University of Minnesota, St. Paul, Minnesota. 1978 A.A. Fine Arts, Rochester Community College, Rochester, Minnesota. RELATED POSITIONS HELD: 7/03 - present Assistant Professor, University of Texas Southwestern Medical Center, Department of Otolaryngology Head and Neck Surgery, Dallas, Texas. 8/05-present Assistant Professor, University of Texas Southwestern Graduate School of Biomedical Sciences-Biomedical Engineering Program, Dallas, Texas. 03/01-04/02& 7/03 - present Adjunct Professor, University of Texas at Dallas Department of Behavioral and Brain Sciences, Richardson, Texas. 04/02- 7/03 Research Scientist, University of Texas at Dallas Department of Behavioral and Brain Sciences, Richardson, Texas. 10/00-7/03 Independent Consultant, Alcon Laboratories Otologic Research Division, Fort Worth, Texas. 9/99-04/02 Book Editing Assistant to Professor Aage Moller, Margaret Fonde Jonnson Chair, University of Texas at Dallas, Richardson, Texas. 1/91-7/00 Senior Research Associate, University of Texas Southwestern Medical Center, Department of Otolaryngology Head and Neck Surgery, Dallas, Texas. 7/82-12/90 Senior Laboratory Technician-Lab Manager, University of Minnesota Department of Otolaryngology Electron Microscopy Laboratory, Minneapolis, Minnesota. 11/80-9/81 Undergraduate Technician, Electron Microscopy Core Facility, University of Minnesota Department of Plant Pathology, St. Paul, Minnesota PROFESSIONAL SOCIETIES: 2010-present 2000-present 1993-present 2005-present 1991-94 1989-92 Sigma Xi [President UTSW Chapter 2010-11, Vice President 2011-present] Society for Neuroscience Association for Research in Otolaryngology UT Southwestern Imaging Society Electron Microscopic Society of America Minnesota Electron Microscopic Society (Secretary, 1990) COMMITTEES: 2011-present 2011-present 2006-present 2003-present 2008-2010 2006-2010 TEACHING: Student Committees: UTSW Institutional Animal Care and Use Committee Association for Research in Otolaryngology Animal Research Committee UTSW Dept. of Otolaryngology Curriculum Committee UTSW Dept. of Otolaryngology Research Committee University of Texas Faculty Advisory Council [Executive Council 09-10] University of Texas Southwestern Medical School Faculty Senate [President 08-09] Master of Science Ph.D. Maritza Rodrigues, Biomedical Engineering, University of Texas Southwestern medical Center, 2007 Guimel Molina, Biology, University of Texas at Arlington, 2006 Bakkyu Lee, Biomedical Engineering, University of Texas at Arlington, Incomplete Che Xu, Biomedical Engineering, University of Texas at Arlington, 2007 Mentorships: Master of Science Pavithra Raghavan, Biomedical Engineering, University of Texas at Arlington, 2008 Postdoctoral Fellow Yayoi Kikkawa, MD, PhD, University of Texas Southwestern Medical Center, 2003-2006 Teaching Courses: Invited Lecturer, Bacterial biofilms in the ear: Otitis media and Cochlear implants, III International Otology Course, Bogotá, Colombia, Nov. 30, 2007. Invited Lecturer, Influences of Micro- and Nano-patterning on Biofilm Formation and Host Response to Cochlear Implants, Metrocon 2006, Fort Worth, Texas Professor-2006-07; Lecturer Fall 2007-2012, Anatomy and Physiology of Hearing, University of Texas at Dallas, Dallas, Texas Invited lecturer 2005-06, Clinical Audiology, University of Texas at Dallas, Dallas, Texas Interviewer- UTSW Dept. of Otolaryngology Resident Match 2005-06, 2008, 2010-12 Interviewer- UTSW Medical School Match 2009-12 Manuscript Reviewer: Laryngoscope Otology and Neurotology Otolaryngology Head and Neck Surgery Annals of Otology Rhinology and Laryngology Infection Journal of the Association for Research in Otolaryngology Journal for Biomedical Materials Research-A International Journal of Audiology Neuroscience Letters Histology and Histopathology Grant Reviewer: Medical Research Council, United Kingdom PUBLICATIONS: 1. 2. 3. 4. 5. 6. 7. 8. Pawlowski KS, Koulich E, Wright CG, Roland PS. Ototopical applications of povidone. Iodine/Dexamethasone in the rat. Otology and Neurotology, 34(1):167-74, 2013. Nielan R, Pawlowski K, Isaacson B, Roland PS. Cochlear implant device failure secondary to cholesterol granuloma-mediated cochlear erosion. Otology and Neurotology, 33(5):733-5, 2012. Pawlowski KS, Koulich E, Cuda D, Wright GW, Stabilini E, Roland PS. Effects of drilling with Piezosurgery Medical Device in rats. Laryngoscope, 212(1):182-6, 2011. Koulich E, Pawlowski KS, Roland PS. Comparison of systemic and otic administration of ofloxacin. Laryngoscope, 120(10):2083-8, 2010. Xu CC, Chan RW, Weinberger DG, Efune G, Pawlowski KS. Controlled release of hepatocyte growth factor from a bovine acellular scaffold for vocal fold reconstruction. Journal of Biomedical Materials Research: Part A, 93(4):1335-47, 2010. Lee M, Pawlowski KS, Luong A, Furze A, Roland PS. Biofilm presence in humans with chronic suppurative otitis media. Otolaryngology-Head and Neck Surgery, 141(5):567-71, 2010. Pawlowski KS, Si E, Wright CG, Koulich E, Hosseini K, Roland PS. Ototoxicity of topical azithromycin solutions in the guinea pig. Archives of Otolaryngology-Head & Neck Surgery, 136(5):481-7, 2010. Xu CC, Chan RW, Weinberger DG, Efune G, Pawlowski KS. A bovine acellular scaffold for vocal fold reconstruction in a rat model. Journal of Biomedical Materials Research: Part A, 92(1):18-32, 2010. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. Pawlowski KS and Roland RS, Ototoxicity, in Ballenger’s Otorhinolaryngology Head and Neck Surgery, 17th ed., 2009, Eds. Snow JB, Wackym PA, BC Decker Inc, London, pp. 273-8. Wawro D, Ding Y, Gimlin S, Zimmerman S, Kearney C, Pawlowski K, Magnusson R. Guidedmode sensors for rapid medical diagnostic testing applications. Proceedings of the Society of Photographic Instrumentation Engineers (SPIE), 7173, 717303 (2009), DOI:10.1117/12.809523, Feb. 20, 2009. Kikkawa YS, Pawlowski KS, Wright GW, Alagramam KN. Development of outer hair cells in Ames waltzer mice: Mutation in protocadherin 15 affects development of cuticular plate and associated structures. Anatomical Record, 291(2)224-232, 2008. Megerian CA, Semaan MT, Aftab S, Kisley LB, Zheng QY, Pawlowski KS, Wright CG, Alagramam KN. A mouse model with postnatal endolymphatic hydrops and hearing loss. Hearing Research 237(1-2):90-105, 2008. Kikkawa YS, Pawlowski KS, Cochlear neuronal tracing for frequency mapping with DiI, NeuroVue, and Golgi methods, Acta Otolaryngologica (Stockholm) Supplement 559:19-23, 2007. Zheng QY, Yu H, Washington JL 3rd, Kisley LB, Kikkawa YS, Pawlowski KS, Wright CG, Alagramam KN. A new spontaneous mutation in the mouse protocadherin 15 gene. Hearing Research. 219(1-2):110-20, 2006. Pawlowski KS, Kikkawa YS, Wright CG, Alagramam KN. Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development. Journal of the Association for Research in Otolaryngology, 219(1-2):110-20, 2006. Pawlowski KS, Wawro D, Roland PS. Bacterial Biofilm Formation on a Human Cochlear Implant. Otology and Neurotology, 26:972-975, 2005. Alagramam KN, Stahl JS, Jones SM, Pawlowski KS, Wright CG. Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F. Journal of the Association for Research in Otolaryngology, 6(2):106-118, 2005. Pawlowski KS. Anatomy and Physiology of the Cochlea. In Ototoxicity, 2004, Eds. Roland PS and Rutka JA, BC Decker Inc, London, pp.1-19. Ulualp SO. Wright CG, Pawlowski KS, Roland PS. Cochlear degeneration in Leigh Disease, histopathologic features. Laryngoscope, 114(12):2239-42, 2004. Ulualp SO, Wright CG, Pawlowski KS, Roland PS. Histopathological basis of hearing impairment in Wolf-Hirschhorn syndrome. Laryngoscope, 114(8):1426-30, 2004. Alagramam KN, Murcia CL, Kwon HY, Pawlowski KS, Wright CG, and Woychik RP. The mouse Ames Waltzer gene encodes a protocadherin required for the normal development of inner ear neuroepithelial cells. Nature Genetics, 27(1):99-102, 2001. Alagramam KN, Zahorsky-Reeves J, Wright CG, Pawlowski KS, Erway LC, Stubbs L, and Woychik RP. Neuroepithelial defects of the inner ear in a new allele of the mouse mutant Ames waltzer, Hearing Research, 148(1-2):181-191, 2000. Wright CG, Pawlowski KS, Roland PS, and Meyerhoff WL. An animal model for external ear canal inflammation. Laryngoscope, 110(7):1112-1118, 2000. (Also presented at the Southern Section of the American Laryngological, Rhinological, and Otological Society Meeting, St. Petersburg Beach, Fla. Jan. 2000.) Pawlowski KS, Wright CG, Meyerhoff WL. Histological demonstration of glycosaminoglycans in inner ear fluids. Acta Otolaryngologica (Stockholm), 118(4):505-10, 1998. Levine JL, Wright CG, Pawlowski KS, Meyerhoff WL. Postnatal persistence of epidermoid rests in the human middle ear. Laryngoscope, 108(1 Pt 1):70-3, 1998. Friedman NR, Wright CG, Pawlowski KS, Meyerhoff WL. Effect of basic fibroblast growth factor on perforated chinchilla tympanic membranes. Ear Nose Throat J, 76(8):559-64, 1997. Badr-El-Dine M, Gerken GM, Wright CG, Robinson KS, Meyerhoff WL. Electrocochleographic evaluation of the guinea pig model of endolymphatic hydrops. Annals of Otology Rhinology and Laryngology, 106(11):934-42, 1997. Wright CG, Robinson KS, Meyerhoff WL External and middle ear pathology in TGF-alphadeficient animals. American Journal of Otology, 17(2):360-5, 1996. White SJ, Wright CG, Robinson KS, Meyerhoff WL. Effect of topical hyaluronic acid on experimental cholesteatoma. American Journal of Otolaryngology, 16(5):312-8, 1995. Jakob T, Wright CG, Robinson K, Meyerhoff WL. Ototoxicity of topical ticarcillin and clavulanic acid in the chinchilla. Archives of Otolaryngology Head and Neck Surgery. 121(1):39-43, 1995. Pownell PH, Wright CG, Robinson KS, Meyerhoff WL.The effect of cyclophosphamide on development of experimental cholesteatoma. Archives of Otolaryngology Head and Neck Surgery, 120(10):1114-6, 1994. 32. 33. 34. 35. Duvall AJ 3rd, Robinson KS. Effects on cochlear morphology of repeated insults to the stria vascularis. Annals of Otology Rhinology and Laryngology, 100(7):572-6, 1991. Duvall AJ 3rd, Robinson KS, Feist SJ. Cochlear permeability of neomycin and gentamicin: an immunohistochemical study. European Archives of Otorhinolaryngology, 248(6):319-25, 1991. Duvall AJ 3rd, Robinson KS. Cochlear vessel permeability to horseradish peroxidase after diuretic administration in the chinchilla. Acta Otolaryngologica (Stockholm), 108(5-6):397-403, 1989. Duvall AJ 3rd, Robinson KS. Local vs systemic effects of acoustic trauma on cochlear structure and transport. Archives of Otolaryngology Head and Neck Surgery, 113(10):1066-71, 1987. PUBLISHED ABSTRACTS: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. Pawlowski K, Koulich E, Wright CG, Roland PS. Lack of ototoxicity from ototopical application of FST-w00 or FST-201. Abrstact 319, Midwinter Research Meeting of the Association for Research in Otolaryngology, San Diego, CA, Feb.26, 2012. Pawlowski K, Koulich E, Kruger P, Isaacson B, and Roland P. Incidence of bacterial biofilms on explanted cochlear implants. Abstract 231, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore, MD Feb.19, 2011. Koulich E, Pawlowski K. Biofilm formation on platinum/iridium electrodes subjected to low-level electrical current. Abstract 232, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore, MD Feb.19, 2011. Pawlowski K, Koulich E, Cuda D, Wright CG, Stabilini E, Roland P. Ultrasonic approach to cochleostomy: Inner ear effects of otic capsule drilling in the rat. Abstract 418, Midwinter Research Meeting of the Association for Research in Otolaryngology, Anaheim, CA Feb. 6, 2010. Koulich E, Raghavan P, Zimmerman S, Pawlowski K. Effect of DC current on biofilm formation on platinum iridium electrodes. Abstract 419, Midwinter Research Meeting of the Association for Research in Otolaryngology, Anaheim, CA Feb. 6, 2010. Pawlowski KS, Si E, Wright C, Koulich E, Hossieni K, Roland PS. Ototoxicity of topical azithromycin solutions in the guinea pig. Abstract 749, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore MD Feb. 18, 2009. Koulich E, Pawlowski KS, Roland PS. Comparison of systemic and otic methods of drug administration in a new animal model of otitis media. Abstract 173, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore MD Feb.15, 2009. Megerian C, Semaan M, Aftab S, Kisley L, Zheng Q, Pawlowski K, Wright C, Alagramam K. A mouse model with postnatal endolymphatic hydrops and hearing loss. Abstract 47, Midwinter Research Meeting of the Association for Research in Otolaryngology, Phoenix AZ Feb. 17, 2008. Kikkawa Y, Pawlowski K, Wright C, Alagramam K. Protocadherin 15 is necessary for the coordinated maturation of apical cell components in developing hair cell. Abstract 661, Midwinter Research Meeting of the Association for Research in Otolaryngology, Phoenix AZ Feb. 19, 2008. Pawlowski KS, Bacterial biofilms in the ear: Otitis media and cochlear implants, Invited Speaker, V Pan-American Congress in Audiology, Bogotá, Colombia, Nov. 29, 2007. Pawlowski KS. Bacterial biofilms in the ear, invited speaker, III International Otology Course, Bogota Colombia, Nov. 30, 2007. Pawlowksi KS, Wawro D, Chan RW, Roland PS, Can linear micro- and nano- patterning of silicone surfaces affect biofilm formation and fibroblast growth? 6th Asia Pacific Symposium on Cochlear Implants and Related Sciences, Sydney Australia, Oct. 31, 2007. Pawlowski KS, Biofilms in Otolaryngology, Invited Speaker, Monterey Surgeons College, Monterey, Mexico July, 2007. Zheng Q, Yu H, Kisley L, Kikkawa Y, Pawlowski K, Wright C, Alagramam K. Characterization of Pcdh15av-6J, an allele of mouse protocadherin 15 Gene. Abstract 382, Midwinter Research Meeting of the Association for Research in Otolaryngology, Denver Co, Feb. 2007. Pawlowksi KS, Wawro D, Magnusson R, Chan RW, Roland PS. Influence of Periodic Micro and Nano Patterning on Fibroblast Growth and Biofilm Formation, UT Metroplex Days, Dallas, TX, 2006. Pawlowski KS. Micro- and nano-patterned features on implant surfaces for reduction of biofilm formation Metrocon 2006, Fort Worth, TX, 2006. Invited Speaker. Pawlowski KS, Kikkawa YS, Wright CG, Alagramam KN. Transmission electron microscopy of the developing mouse outer hair cell cuticular plate and associated structures. Abstract 824, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore MD, Mar. 2006. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. Alagramam KN, Zheng Q, Yu H, Jones SM, Pawlowski KS, Kikkawa YS, Wright CG. Functional analysis of protocadherin 15. Abstract 367, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore MD, Mar. 2006. Zheng Q, Yu H, Pawlowski KS, Kikkawa YS, Wright CG, Washington J, Kisley L, Alagramam KN. Characterization of a new allele of Ames waltzer, Pcdh15 Av-6J. Abstract 370, Midwinter Research Meeting of the Association for Research in Otolaryngology, Baltimore MD, Mar. 2006. Kikkawa YS, Pawlowski KS. Cochlear Neuronal Tracing and frequency mapping with DiI and Golgi methods. Mouse as an Instrument in Ear Research II, The Jackson Laboratory, Bar Harbor, Me, Oct. 2005. Pawlowski KS, Wawro D, Roland PS. Bacterial biofilm formation on human cochlear implants. 10th Symposium on Cochlear Implants in Children, Dallas, TX, March 15-19, 2005. Pawlowski KS, Infection and biofilms in the cochlea. Presentation to Med El Corporation at Asilomar, Ca, July 2005. Invited Speaker. Kikkawa YS, Pawlowski KS, Wright CG, Alagramam KN. Morphological analysis of Ames waltzer (AV) mice and developmental and spatial expression of protocadherin 15. Abstract 621, Midwinter Research Meeting of the Association for Research in Otolaryngology, New Orleans, La, Feb, 2005. Pawlowski KS, Wright CG, Alagramam KN. Progression of Inner Ear Pathology in Ames waltzer Mice. Abstract 615, Midwinter Research Meeting of the Association for Research in Otolaryngology, New Orleans, La, Feb, 2005. Pawlowski KS, Wright CG, Alagramam KN. Ultrastructure of inner and outer hair cells of Ames Waltzer mice during development. Abstract 226, Midwinter Research Meeting of the Association for Research in Otolaryngology, Daytona Beach, FL, Feb. 2004. Alagramam KN, Stahl JS, Jones SJ, Pawlowski KS, Wright CG. Characterization of vestibular function in Ames waltzer mice. Abstract 980, Midwinter Research Meeting of the Association for Research in Otolaryngology, Daytona Beach, FL, Feb. 2004. Wright CG, Pawlowski KS, Alagramam KN. Epidermoid rests in the developing mouse middle ear. Abstract 387, Midwinter Research Meeting of the Association for Research in Otolaryngology, Daytona Beach, FL, Feb. 2003. Alagramam KN, Adappa N, Pawlowski KS, Wright CG. Towards functional analysis of protocadherin 15, the gene associated with Ames waltzer (AV) mouse mutation and Usher Syndrome 1F. Abstract 519, Midwinter Research Meeting of the Association for Research in Otolaryngology, Daytona Beach, FL, Feb. 2003. Alagramam KN, Erway LC, Pawlowski KS, Wright CG. Characterization of protocadherin 15, the gene associated with the mouse mutation Ames waltzer (AV). Abstract 569, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, Feb. 2002. Alagramam KN, Murcia C, Erway LC, Pawlowski KS, Wright CG, and Woychik R. Molecular and phenotypic characterization of the mouse mutation Ames waltzer. Abstract 515, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 2001. Pawlowski KS, Caller L, Wright CG. Immunohistochemical demonstration of sulfated GAGs in guinea pig inner ear fluids. Abstract 5512, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 2000. Alagramam KN, Rohrbaugh CL, Zahorsky-Reeves J, Stubbs L, Erway LC, Pawlowski KS, Wright CG, Woychik RP. Molecular characterization of a new murine deafness mutant that is allelic with Ames Waltzer. Abstract #221, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1999. Pawlowski KS, Wright CG, Gerken G. A simple technique for quantitation of cochlear hydrops. Abstract #780, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1998. Wright CG, Pawlowski KS, Bachor E, Karmody CS. Epithelial formations of the inferior utricular sinus. Abstract #38, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1998. C.G. Wright, K.S. Pawlowski, L.J. Stubbs, C.T. Culiat. Cochleosaccular degeneration and vestibular atelectasis in a new mouse mutant. Abstract #444, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1997. Pawlowski KS, Wright CG. Histological demonstration of glycosaminoglycans in inner ear fluids. Abstract #634, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1997. 37. 38. 39. 40. Wright CG, Robinson KS. Use of scanning electron microscopy for study of human otoconia. Abstract #804, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1996. Wright CG, Robinson KS, Comerford SA. Transforming growth factor alpha in the adult mammalian inner ear. Abstract #435, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1995. Wright CG, Robinson KS, Comerford SA. Abnormalities of the stria vascularis and dark cell epithelium in transgenic mice with ocular melanoma. Abstract # 835, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1994. Wright CG, Marple BF, Robinson KS, Meyerhoff WL. Cochlear deafferentation in congenital Rubella, Abstract #28, Midwinter Research Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL., Feb. 1993. GRANTS AND CONTRACTS: 1. Molecular deafness in Usher Syndrome IIIA, Collaborator with Kumar Alagramam, Case Western Reserve from NIDCD NIH-RO1 1/2011-12/2014. 2. Ototoxic potential of an ototopical application of a medication containing FST 200 or FST 201 (2% or 1% providone iodine with 0.1% dexamethasone). Contract with Foresight Biotherapeutics, New York, NY, Feb-Dec 2011. 3. Effects of Absorbance enhancers on antibiotic concentrations in the middle ear after ototopical application. Contract with Actin Biomedical, New York, NY, July-Oct 2011. 4. Ototoxicity Screening of Azithromycin Solutions for Ototopical Use, Contract with Insite Vision Incorporated, Alameda, California 4/2008-3/2009. 5. Tympanic Membrane Permeability to Otic Agents, Contract with Alcon Laboratories, Fort Worth, TX 8/2007-4/2009. 6. Development of Resonant Waveguide-Granting elements for high throughput screening of proteins, SBIR-Contract with Resonant Sensors, Inc. Arlington, TX 8/2008-7/2009. 7. Non-charge-balanced electrical stimulation for biofilm removal on cochlear implant: in-vitro and in-vivo studies, Grant from UT Dallas-UTSW Joint Research Program 4/2007-8/2008. 8. Molecular and morphological analysis of protocadherin 15 in vestibular stereocilia development, Grant from Deafness Research Foundation, Washington, DC 7/2006-6/2007. 9. Penetration of fluoroquinolones, ciprofloxacin or moxifloxacin, into external ear canal tissues during inflammation, Contract with Alcon Laboratories, Inc. Fort Worth, TX 10/2006-2/2007. 10. Animal models for assessing the safety and biocompatibility of otic products, Contract with Alcon Research Ltd, Fort Worth, TX 11/2003-7/2009. 11. Presence of bacterial biofilms on multiply sterilized titanium mandibular reconstruction plates, Grant from AO North America 6/2006-5/2007. 12. Experimental drug delivery system using Med-El cochlear implants, Grant from Med-El Clinical Research Fund, Durham, NC 11/2004-11/2005. 13. Efficacy of ototopical antibiotic agents on external canal inflammation, Contract with Alcon Research Ltd, Fort Worth, TX 11/2004-11/2005. 14. Molecular genetics of deafness in the Ames waltzer model, Collaborator with Kumar Alagramam, Case Western Reserve, NIDCD NIH-RO1 4/2002-3/2006.