Advanced processing of biomaterials Compiled and edited by Roger J Narayan Published April 2010 FREELY AVAILABLE ONLINE UNTIL 30 NOVEMBER 2010 Special offer price for print issue: £47.50 (usual price: £58) The natural human desire to reduce the limitations caused by disability propels the study of novel medical devices. Novel microscale and nanoscale techniques for processing metals, ceramics, polymers, and natural materials are being developed that will enable enhanced diagnosis and treatment of medical conditions. Recent advances in the development of nanostructured materials for medical applications have resulted from two forces: first, there is a natural transition from the microscale to the nanoscale as novel processing, characterization, and modeling techniques become available; second, nanostructured biomaterials provide the capability for specific interactions with DNA, proteins, viruses, subcellular organelles, and other nanoscale biological structures. As a result, nanostructured biomaterials may provide unique functionalities that are not seen with conventional microstructured materials. This volume discusses advanced techniques for processing materials that may be used in scaffolds for tissue engineering, biosensors, functional medical prostheses, and other medical devices. Access at: rsta.royalsocietypublishing.org/site/issues/biomaterial_processing.xhtml The print issue is available at the specially reduced price shown above. To place an order at this price, please send payment by cheque (made payable to Portland Customer Services) or by Visa or MasterCard (quoting reference TA 1917) to: Portland Customer Services, Commerce Way, Colchester CO2 8HP, UK Tel: +44 (0)1206 796351 Email: sales@portland-services.com Philosophical Transactions A welcomes unsolicited Theme Proposals. For further information on how to become a Guest Editor of the journal, please visit rsta.royalsocietypublishing.org and click on ‘Guest Editor Information’. Alternatively, please contact us at philtransa@royalsociety.org Full contents listed overleaf… Contents Preface: The next generation of biomaterial development RJ Narayan Building off-the-shelf tissue-engineered composites T Burg, CAP Cass, R Groff, M Pepper and KJL Burg Wetting behaviour of laser synthetic surface microtextures on Ti–6Al–4V for bioapplication NB Dahotre, SR Paital, AN Samant and C Daniel Vascular tissue engineering by computer-aided laser micromachining A Doraiswamy and RJ Narayan The role of disc-type crystal shape for micromechanical predictions of elasticity and strength of hydroxyapatite biomaterials A Fritsch, C Hellmich and L Dormieux Molecular mechanisms of crystallization impacting calcium phosphate cements JL Giocondi, BS El-Dasher, GH Nancollas and CA Orme Use of unnatural amino acids for design of novel organomodified clays as components of nanocomposite biomaterials KS Katti, AH Ambre, N Peterka and DR Katti Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering H-F Ko, C Sfeir and PN Kumta Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays LE Murr, SM Gaytan, F Medina, H Lopez, E Martinez, BI Machado, DH Hernandez, L Martinez, MI Lopez, RB Wicker and J Bracke Atomic layer deposition-based functionalization of materials for medical and environmental health applications RJ Narayan, SP Adiga, MJ Pellin, LA Curtiss, AJ Hryn, S Stafslien, B Chisholm, C-C Shih, C-M Shih, S-J Lin, Y-Y Su, C Jin, J Zhang, NA Monteiro-Riviere and JW Elam Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering J Venugopal, MP Prabhakaran, Y Zhang, S Low, AT Choon and S Ramakrishna Osteoblast adhesion, proliferation and growth on polyelectrolyte complex–hydroxyapatite nanocomposites D Verma, KS Katti and DR Katti Biomaterials by freeze casting UGK Wegst, M Schecter, AE Donius and PM Hunger Biologically active collagen-based scaffolds: advances in processing and characterization IV Yannas, DS Tzeranis, BA Harley and PTC So denotes articles that are free to access via EXiS Open Choice