CURRICULUM VITAE
MAРИO ФЕДЯ СИМЕОНОВ
mario.simeonov@hotmail.com
GSM: 0893588821
РЕЗЮМЕ:
ЯМР спектроскопия, биофизична химия, аналитична химия, лекарствен
дизайн, лекарствен метаболизъм
I. ОБРАЗОВАНИЕ:
1980 - Доктор (Ph.D.) научна степен, естествени науки, органична химия, физични
методи, ЯМР спектроскопия, БЪЛГАРСКА АКАДЕМИЯ НА НАУКИТЕ, София,
България
1975 -1980 Докторант, БЪЛГАРСКА АКАДЕМИЯ НА НАУКИТЕ, София
1967 – 1972 – инженер-химик, УНИВЕРСИТЕТ ПРОФЕСОР Д-Р АСЕН ЗЛАТАРОВ
Бургас
II. СПЕЦИАЛИЗАЦИИ:
Bulgarian-Finish Academic Exchange Program – 1990, 1995, 1996, 1997;
Prof. Dr. K. Pihlaja, University of Turku, Finland;
Heinrich-Hertz Foundation, Germany – 1983, 1985, 1987; Prof. Dr. H. Duddeck, RuhrUniversity, Bochum, Germany.
DAAD, Germany – 1986; Prof. Dr. Horst Kessler, University of Frankfurt, Germany,
British Council, England –1979; Prof. Dr. Ed. Randall, University of London, London
III. ЗАЕМАНИ ДЛЪЖНОСТИ:
2010 – present - Assoc. Prof., “Prof. A. Zlatarov University”, Burgas, Bulgaria
August 2007- December 2008 - Research Associate, UAB, Birmingham, AL, USA
February 2006 - May 2006 – Research Scientist, AS LP, Exton PA, USA
September 2003– January 2006 - Research Associate Professor, (PI, Prof. Dr. Mario
Rivera, University of Kansas, Lawrence, KS), USA
June 2000 - September 2003 - Research Associate Professor, Prof. Dr. Jeffrey Urbauer,
University of Kansas, Lawrence, KS, USA
September 1997-April 1999 - Postdoctoral Research Fellow, Prof. Dr. M. Stones,
Vanderbilt University, Nashville, TN, USA
1998 - 2002 – старши научен сътрудник, ИОХЦФ, БЪЛГАРСКА АКАДЕМИЯ НА
НАУКИТЕ, София
1980 – 1998 - научен сътрудник, ИОХЦФ, БЪЛГАРСКА АКАДЕМИЯ НА
НАУКИТЕ, София
1980 – 1997 – преподавателска дейност, ИОХЦФ, СУ-Химически факултет,
Югозападен университет, Благоевград
IV. ИЗСЛЕДОВАТЕЛСКИ ИНТЕРЕСИ:
Приложение на ЯМР спектроскопията за структурни, стереохимични и динамични
изследвания в областта на органичната химия, фитохимия и структурна биологияпротеини и ДНК фрагменти.
- Application of 1D and 2D NMR techniques and methodology (e.g. ab initio
manner) for study of structure, stereochemistry and dynamic of complex
synthetic, or small natural organic compounds with biological activity (19751997).
- Computational methods in chemistry (molecular mechanics (MM), semi-empirical
MO methods for molecular modeling of organic compounds and bio-molecules)
(1992 - 1997)
- Bio-molecular NMR spectroscopy/Structural Biology of DNA Adducts - (199799) Vanderbilt University, Nashville, TN
- 3D solution structure of protein and protein-peptide complexes by high resolution
3D NMR spectroscopy and MD calculations (2000-2003), University of Kansas,
Lawrence, KS
- 3D solution structure and dynamics of heme-proteins (2003- 2006)
University of Kansas, Lawrence, KS, (PI in the group of Prof. Dr. M. Rivera)
- Protein structure and dynamics by NMR spectroscopy (2007 – 2008) UAB,
Birmingham, AL
V. COURSES OFFERED:
- Physical/Instrumental Methods in Chemistry
- Organic Analysis
- Analytical Chemistry
VI. ПУБЛИКАЦИИ:
Повече от 40 публикации в областта на приложение на ЯМР спектроскопията за
структурни, стереохимични и динамични изследвания в органичната химия и структурната
биология.
Изнесени са научни доклади на престижни международни конференции в областта
на ЯМР спектроскопия като ISMAR, AMPER, Keystone Symposium on Frontiers of
NMR in Biology, NMR in Chemistry and Stereochemistry, Chemistry of Natural
Products и други в САЩ, Германия, Англия, Испания, Израел, Финландия, Чехия и
др.
LIST OF PUBLICATIONS:
1. I. Mladenov, K. Kurtev and M. Simeonov, Jahrbuch der hochshule fur
ChemischeTechnologie, Bourgas, X 195 (1973);
2. S. Spassov and M. Simeonov, “Conformational Study of Dibenzyl by means of 13CSatellite NMR spectra”, Compt. Rend. Bulg. Acad. Sci., 29 1145 (1976);
3. S. Spassov and M. Simeonov, “Conformationl Study of Some Biologically Active 1,2Disubstituted Ethanes by means of NMR-spectroscopy”, Compt. Rend. Bulg. Acad. Sci.,
30 723 (1977);
4. M. Simeonov, I. Bangov, S. Spassov and R. Radeglia, “NMR and Theoretical
Conformational Investigation of Some 3-Substituted Propionitriles”, Journal of
Molecular Structure, 65 189 (1980);
5.
S. Spassov, M. Simeonov and E. W. Randall, “1H and 1R Study of Hydrogen
Bonding and Conformation of Some 2-Substituted Ethanols”, Journal of Molecular
Structure, 77 289 (1981);
6.
K. Troev and M. Simeonov, “On the Side Reactions accompaning the TransEsterification on the Acid Diesters of Phosphorous Acids”, Phosphorous and Sulfur, 19
363 (1984);
7.
L. Lazarov, M. Simeonov and S. Marinov, “Structural Analysis of alkylated Coal
by 1H and 13C NMR Spectroscopy”, Fuel, 63 552 (1984);
8.
L. Markova, M. Simeonov, S. Spassov, A. Bojilova and C. Ivanov, “1H and 13C
NMR Spectra and Stereochemistry of Substituted 3,4-hydrocoumarines”, Commun. Dept.
Chem. Bulg. Acad. Sci., 18(1) 123 (1985);
9.
M. Simeonov, S. Spassov, A. Bojilova, C. Ivanov and R. Radeglia,
“Conformational and Tautomeric Equilibria of 3-Acyl-3,4-Dihydrocoumarins: 1H and
13C NMR Study”, 127 127 (1985);
10.
B. Mikhova, M. Simeonov and S. Spassov, “Applicability of Vicinal Heteronuclear
(13C-1H, 15N-1H, 13C-15N) Coupling constants for Conformational Analysis of
Aminoacids: Phenylalanine, -Aminobutiric acid and -Alanine”, Magnetic Resonance
in Chemistry, 23 (6) 474 (1985);
11.
T. Nikiforov and M. Simeonov, “Synthesis and Absolute Configuratin of
Diasteriomeric 3-Substituted 1-((S)-1-Phenylethyl)-2-Pyrrolidinones”, Commun. Dept.
Chem. Bulg. Acad. Sci., 39 (3) 73 (1986);
12.
J. Sandstrom, M. Simeonov and S. Spassov, “Rotational Isomerism of N,NDiacyl-1,2-Diaminoethanes and Their Thio Analogues as Studied by 1H and 13C NMR
and by Molecular Mechanics”, Acta Chemica Scandinavica, B42 183 (1988);
13.
M. Simeonov, S. Spassov, H. Duddeck, U. Maichrzak-Kuczynska and J. Skolik,
“Complete 1H and 13C NMR Assignment of Two -Isosparteine Salts by the Use of TwoDimensional NMR Spectroscopy”, Magnetic Resonance in Chemistry, 27(5) 476 (1989);
14.
H. Duddeck, M. Hiegemann, M. Simeonov, B. Kojic-Prodic, B. Nigovic and V.
Magnus, “Conformational Study of Some Amino Acid Conjugates of Indol-3-yl-acetic Acid
(IAA) by 1H-NOE-Difference Spectroscopy. Structure/Auxine activity Relationship”,
Zeitschrift fur Naturforschung (Tubingen), 44c (7-8) 543 (1989);
15. S. Spassov, M. Simeonov, B. P. Mikhova and P. S. Denkova, “Application of Modern
NMR Techniques for Conformational Analysis and Assignment of NMR Parameters of
Biologically Active Compounds”, Journal of Molecular Structure, 217 169 (1990);
16.
F. Fulop, M. Simeonov, and K. Pihaja, “Formation of 1,2-Dihydroquinazolin4(3H)-ones. Reinvestigation of a Recently Reported 1,3,4-Benzotriazepine Synthesis”,
Tetrahedron, 48 531-538 (1992);
17.
M. Simeonov, F. Fulop, R. Sillanpaa and K. Pihlaja, “2D NMR Variable
Temperature Study of Conformational Complexity in Seven-Membered Cyclic
Triazepinone/Open-Chain Hydrazones”, TAMU NMR Newsletter No. 387, 3 (1990);
18.
K. Pihlaja, M. Simeonov, M. Michalik, K. Peseke, V. Sinnwell and J. Voss,
“Tautomerism of Some Alkyl Carboxylates of Amino-substituted Dihydrobenzoxazepine
Thiones and Dihydrobenzodiazepiine Thiones by 2D NMR Spectroscopy. Some
Stereochemical Effects on 2J(C,H) and 3J(C,H) Couplings”, Magn. Reson. Chem., 30
673-677 (1992);
19.
I. Ivanov, St. Karagiosov and M. Simeonov, “A Facile Synthesis of 5-Oxo-5H(1)Benzopyrano(4,3b)Pyridines. A New Case of N,N-Alkyl Migration”, Liebigs Ann.
Chem., 203 (1992);
20.
J. Chiara, R. Petrova, M. Simeonov, S. Spassov, A. Khan and J. Sandstrom,
“Stereochemical Studies of N,N-Diacetyl-N,N-Dimethyl-1,2-Diamino-1,2-Diphenylethanes
and Their Mono- and Dithio Analogues by NMR and CD Spectroscopy and by Molecular
Mechanics Calculations”, Acta Chemica Scandinavica Ser B, 46(6) 555 (1992);
21.
K. Neuvonen, F. Fulop, H. Neuvonen, M. Simeonov and K. Pihlaja, “Correlation
Analysis of the 13C Chemical Shifts of Substituted Benzaldehyde 2Aminobenzoylhydrazones. Study of the Propagation of Substituent Effects Along A
Heteroatomic Chain”, J. Physical Organic Chemistry, 10 55 (1997);
22.
K. Pihlaja, M. Simeonov and F. Fulop, “Conformational Complexity in SevenMembered Cyclic Triazepinone/Open Hydrazones. Part 1. 2D Variable Temperature NMR
Study”, J. Org. Chem., 62(15) 5080 (1997);
23.
M. Simeonov, F. Fulop, R. Sillanpaa and K. Pihlaja, “Conformational Complexity
in Seven-Membered Cyclic Triazepinone/Open Hydrazones. Part II. Molecular Modelling
and X-Ray Study”, J. Org. Chem., 62(15) 5089 (1997);
24.
V. Christov, M. Simeonov and L. Evstatieva, “Alkaloid Content of Species from
Genus Senecio”, Compt. Rend. Bulg. Acad. Sci., 50(1) 47 (1997);
25.
V. Christov, M. Simeonov, N. Velcheva, O. Karadjova, N. Atanassov, I. Ivanova
and L. Evstatieva, “Pyrrolizidine Alkaloids from Bulgarian Species-Genus Senecio and
Their Insecticidal Properties”, Biotechnology and Biotechnological Ed., 11(1) 53
(1997);
26.
I. Kostova, M. Simeonov, I. Iossifova, R. Tappe, N. Pardeshi and H. Budzikiewicz,
“Three 9,19-Cyclotetracyclic Triterpenes from Skimmia Wallichii”, Phytochemistry,
43(3) 643 (1996);
27.
Ch. Roussev, M. Simeonov, and D. Petkov, “Arabinonucleotides Bond Synthesis
by the Epoxide Route”, J. Org. Chem., 62(15) 5238 (1997);
28.
I. Kostova, M. Simeonov and D. Todorova, “A Monoterpene Glucoside from
Peonia Peregina Roots”, Phytochemistry, 47 (7) 1303 (1998);
29.
I. Kostova, M. Simeonov, D. Todorova and P. Petkova, “Two Acylated
Monoterpene Glucosides from Paeonia Peregina”, Phytochemistry, 48(3) 511 (1998);
30.
Iv. Stankova, M. Simeonov, V. Maximova, A. Galabov and Ev. Golovinsky,
“Synthesis and Anti-Virus Activity of Some Nucleosides Analogues”, Z. Naturforsch., 54c
75 (1999);
31.
M. Simeonov, P. J. Tamura, A. Slick, C. M. Harris, T. M. Harris and M. P. Stone,
“Sequence- and Stereospecific Conformational Rearrangement of the R(61,3)- and
S(61,3)--(N6-Adenyl) Styrene Oxide (SO) Adducts Located at A.C Mismatch Base Pairs
in an Oligodeoxynucleotide Containing the Human N-ras codon 61”, Biochemistry, 39(5)
924-937 (2000);
32. J. Urbauer, K. Adelman, R. J. Bieber Urbauer, M. Simeonov, J. M. Gilmore, M.
Zolkiewski and Ed. N. Brody, “Conserved Region 4.1 and 4.2 of sigma-70 Constitute the
Recognition Sites for the Anti-sigma Factor AsiA, and AsiA Is a Dimer Free in Solution”,
J. Biol. Chem., 276 (44) 41128-41132 (2001);
33. J. Urbauer, M. Simeonov, R. J. Bieber Urbauer, K. Adelman, J. M. Gilmore and Ed.
N. Brody “ Solution Structure and Stability of the Anti-sigma Factor AsiA and
Implications for Novel Functions’”, Proc. Natl. Acad. Sci. USA, 99 (4) 1831-1835
(2002);
34. M. Simeonov, R. J. Bieber Urbauer, J. M. Gilmore, K. Adelman, Ed. N. Brody, A.
Niedziela-Majka, L. Minakhin, T. Heyduk and J. L. Urbauer, "Characterization of the
Interactions Between the Bacteriophage T4 AsiA Protein and RNA Polymerase",
Biochemistry, 42, 7717-7726 (2003);
35. M. Simeonov, R. J. Bieber Urbauer, J. M. Gilmore, K. Adelman, Ed. N. Brody and J.
L. Urbauer, “High-Resolution NMR solution structure of the AsiA-region 4 of sigma 70
of RNA Polymerase complex” (in preparation);
36. Mario Simeonov, Adriana Altuve, Michael A. Massiah, An Wang, Margaret A.
Eastman, A, David R. Benson, and Mario Rivera, “Mitochondrial and Microsomal
Ferric Cytochromes b5, Exhibit Identical Fold but Different Conformational Plasticity”,
Biochemistry (2005) (http://dx.doi.org/10.1021/bi050564l);
37. Mario Simeonov, M. Rivera “NMR Dynamics Study of Mitochondrial and Microsomal
Ferric Cytochromes b5 Proteins” (in preparation);
38. Nenad Juranic ‡*, Mario F. Simeonov §, Keith A. Jones §, Alan R. Penheiter ‡,
Thomas J Hock §, and John H. Streiff § “Halothane Binds [Ca2+] 4-CaM, but Does Not
Inhibit [Ca2+] 4-CaM Activation of Skeletal Muscle Myosin Light-Chain Kinase †”‡Mayo
College of Medicine and §University of Alabama at Birmingham (in preparation);
39. Mario F. Simeonov §, Nenad Juranic ‡*, John H. Streiff and Keith A. Jones § NMR
Dynamics of Halothane [Ca2+] 4-CaM Complex” †”‡Mayo College of Medicine and
§
University of Alabama at Birmingham (in preparation);