PUBLICATIONS
Ben-Ze'ev, H. (1972). The development of the phage CP-51 trapped in spores of B. cereus during spore
germination. M.Sc. Thesis, Hebrew University, Jerusalem, Israel.
Cohen, A., Ben-Ze'ev, H. and Yashouv, J. (1973). Outgrowth of Bacillus cereus spores harboring
bacteriophage CP-51 DNA. I. Initiation of bacteriophage development. J Virol 11: 648-654.
Mazor, Z., Ben-Ze'ev, H., Silberstein, Z. and Cohen, A. (1974). Bacillus cereus outgrowth "early proteins"
and their possible role in control of transcription. Adv Exp Med Biol 44: 25-35.
Ben-Ze'ev, H., Hattori, J., Silberstein, Z., Tesone, C. and Torriani, A. (1975). Ribonucleic acid polymerase
from dormant and germinating spores of Bacillus cereus T. Spores IV, American Society for Microbiology.
Washington. 472-477.
Cohen, A., Ben-Ze'ev, H. and Silberstein, Z. (1975). Control of temporal gene expression during outgrowth
of Bacillus cereus spores. Spores IV. American Society for Microbiology. Washington. 478-482.
Hattori, J., Ben-Ze'ev, H., Silberstein, Z., Tesone, C. and Torriani, A. (1975). Ribonucleic acid polymerase
of germinating Bacillus cereus T. J Bacteriol 124: 542-549.
Sussman, R. and Ben-Ze'ev, H. (1975). Proposed mechanism of bacteriophage lambda induction:
acquisition of binding sites for lambda repressor by DNA of the host. Proc Natl Acad Sci U S A 72: 19731976.
Sonenshein, A. L., Alexander, H. B., Rothstein, D. M. and Fisher, S. H. (1977). Lipiarmycin-resistant
ribonucleic acid polymerase mutants of Bacillus subtilis. J Bacteriol 132: 73-79.
Sonenshein, A. L. and Alexander, H. B. (1979). Initiation of transcription in vitro inhibited by lipiarmycin.
J Mol Biol 127: 55-72.
Lerner, R. A., Green, N., Alexander, H., Liu, F. T., Sutcliffe, J. G. and Shinnick, T. M. (1981). Chemically
synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit
antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci USA 78: 34033407.
Bittle, J. L., Houghten, R. A., Alexander, H., Shinnick, T. M., Sutcliffe, J. G., Lerner, R. A., Rowlands, D. J.
and Brown, F. (1982). Protection against foot-and-mouth disease by immunization with a chemically
synthesized peptide predicted from the viral nucleotide sequence. Nature 298: 30-33.
Green, N., Alexander, H., Olson, A., Alexander, S., Shinnick, T. M., Sutcliffe, J. G. and Lerner, R. A.
(1982). Immunogenic structure of the influenza virus hemagglutinin. Cell 28: 477-487.
Alexander, H., Johnson, D. A., Rosen, J., Jerabek, L., Green, N., Weissman, I. L. and Lerner, R. A. (1983).
Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino
acids. Nature 306: 697-699.
Gerin, J. L., Alexander, H., Shih, J. W., Purcell, R. H., Dapolito, G., Engle, R., Green, N., Sutcliffe, J. G.,
Shinnick, T. M. and Lerner, R. A. (1983). Chemically synthesized peptides of hepatitis B surface antigen
duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci
USA 80: 2365-2369.
Milich, D. R., Alexander, H. and Chisari, F. V. (1983). Genetic regulation of the immune response to
hepatitis B surface antigen (HBsAg). III. Circumvention of nonresponsiveness in mice bearing HBsAg
nonresponder haplotypes. J Immunol 130: 1401-1407.
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Shinnick, T. M., Sutcliffe, J. G., Gerin, J. L., Purcell, R. H., Bittle, J. L., Alexander, H., Rowlands, D. J.,
Brown, F. and Lerner, R. A. (1983). The chemical nature of antiviral serotype specificity. Affinity
Chromatography and Biological Recognition. (Chaiken, I. M.). Academic Press, Inc., Orlando. 343-353.
Alexander, H. and Lerner, R. A. (1984). Chemically synthesized peptide analogs of the hepatitis B Surface
Antigen. Advances in Hepatitis Research. (Chisari, F. V.). Masson Publishing USA, Inc., New York. 223229.
Dillner, J., Sternas, L., Kallin, B., Alexander, H., Ehlin-Henriksson, B., Jornvall, H., Klein, G. and Lerner,
R. (1984). Antibodies against a synthetic peptide identify the Epstein-Barr virus- determined nuclear
antigen. Proc Natl Acad Sci USA 81: 4652-4656.
LeGrice, S. F. J., Alexander, H., Miller, S. and Sonenshein, A. L. (1984). Inhibition of lipiarmycin of
Bacillus subtilis RNA polymerase. Genetics and Biotechnology of Bacilli. (Ganesan, A. T. and Hoch, J.).
Academic Press, Inc., Orlando. 223-234.
Shinnick, T. M., Sutcliffe, J. G., Green, N., Bittle, J. L., Alexander, H., Lerner, R. A., Gerin, J. L.,
Rowlands, D. J. and Brown, F. (1984). Molecular basis of antivirus serotype specificity. Modern
Approaches to Vaccines. (Channock, R. M. and Lerner, R. A.). Cold Spring Harbor Press, New York. 7785.
Tainer, J. A., Getzoff, E. D., Alexander, H., Houghten, R. A., Olson, A. J., Lerner, R. A. and Hendrickson,
W. A. (1984). The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a
protein. Nature 312: 127-134. (COVER ARTICLE)
Dillner, J., Kallin, B., Klein, G., Jornvall, H., Alexander, H. and Lerner, R. (1985). Antibodies against
synthetic peptides react with the second Epstein- Barr virus-associated nuclear antigen. EMBO J. 4: 18131818.
Moriarty, A. M., Alexander, H., Lerner, R. A. and Thornton, G. B. (1985). Antibodies to peptides detect
new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science 227: 429-433.
Dillner, J., Kallin, B., Alexander, H., Ernberg, I., Uno, M., Ono, Y., Klein, G. and Lerner, R. A. (1986). An
Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformationassociated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl
Acad Sci USA 83: 6641-6645.
Getzoff, E. D., Geysen, H. M., Rodda, S. J., Alexander, H., Tainer, J. A. and Lerner, R. A. (1987).
Mechanisms of antibody binding to a protein. Science 235: 1191-1196.
Geysen, H. M., Tainer, J. A., Rodda, S. J., Mason, T. J., Alexander, H., Getzoff, E. D. and Lerner, R. A.
(1987). Chemistry of antibody binding to a protein. Science 235: 1184-1190.
Norrby, E., Mufson, M. A., Alexander, H., Houghten, R. A. and Lerner, R. A. (1987). Site-directed serology
with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Proc Natl Acad
Sci USA 84: 6572-6576.
Ricksten, A., Kallin, B., Alexander, H., Dillner, J., Fahraeus, R., Klein, G., Lerner, R. and Rymo, L. (1988).
BamHI E region of the Epstein-Barr virus genome encodes three transformation-associated nuclear
proteins. Proc Natl Acad Sci USA 85: 995-999.
Sussman, R. and Alexander, H. B. (1989). Structural analysis of the carboxy terminus of bacteriophage
lambda repressor determined by antipeptide antibodies. J Bacteriol 171: 1235-1244.
2
Alexander, H., Alexander, S., Heffron, F., Fieser, T. M., Hay, B. N., Getzoff, E. D., Tainer, J. A. and Lerner,
R. A. (1991). Synthesis and characterization of a recombinant myohemerythrin protein encoded by a
synthetic gene. Gene 99: 151-156.
Alexander, H. (1992). Probing the antigenicity of myohemerythrin. Ph.D. Thesis, University of Missouri,
Columbia, MO.
Alexander, H., Alexander, S., Getzoff, E. D., Tainer, J. A., Geysen, H. M. and Lerner, R. A. (1992). Altering
the antigenicity of proteins. Proc Natl Acad Sci USA 89: 3352-3356.
Alexander, H. (1996). Epitope mapping using an oligonucleotide replacement method. Epitope Mapping
Protocols. (Morris, G.). Humana Press, Inc., Totowa. 221-232.
Alexander, H. and Alexander, S. (1996). Identification of introns by reverse-transcription PCR.
Biotechniques 20: 778-780.
Alexander, H., Lee, S. K., Yu, S. L. and Alexander, S. (1996). repE--the Dictyostelium homolog of the
human xeroderma pigmentosum group E gene is developmentally regulated and contains a leucine zipper
motif. Nucleic Acids Res 24: 2295-2301.
Lee, S. K., Yu, S. L., Alexander, H. and Alexander, S. (1996). Increasing the specificity of colony
hybridization when using heterologous probes. Biotechniques 21: 630-632.
Lee, S. K., Li, G., Yu, S. L., Alexander, H. and Alexander, S. (1997). The Dictyostelium discoideum -1,4mannosyltransferase gene, mntA, has two periods of developmental expression. Gene 204: 251-258.
Lee, S. K., Yu, S. L., Garcia, M. X., Alexander, H. and Alexander, S. (1997). Differential developmental
expression of the rep B and rep D xeroderma pigmentosum related DNA helicase genes from
Dictyostelium discoideum. Nucleic Acids Res 25: 2365-2374.
Lee, S. K., Yu, S. L., Alexander, H. and Alexander, S. (1998). A mutation in repB, the Dictyostelium
homolog of the human xeroderma pigmentosum B gene, has increased sensitivity to UV-light but normal
morphogenesis. Biochim Biophys Acta 1399: 161-172.
Yu, S. L., Lee, S. K., Alexander, H. and Alexander, S. (1998). Rapid changes of nucleotide excision repair
gene expression following UV-irradiation and cisplatin treatment of Dictyostelium discoideum. Nucleic
Acids Res 26: 3397-3403.
Srinivasan, S., Alexander, H. and Alexander, S. (1999). The prespore vesicles of Dictyostelium
discoideum. Purification, characterization, and developmental regulation. J Biol Chem 274: 3582335831.
Garcia, M. X. U., Foote, C., van Es, S., Devreotes, P. N., Alexander, S. and Alexander, H. (2000).
Differential developmental expression and cell type specificity of Dictyostelium catalases and their
response to oxidative stress and UV- light. Biochim Biophys Acta 1492: 295-310.
Li, G., Alexander, H., Schneider, N. and Alexander, S. (2000). Molecular basis for resistance to the
anticancer drug cisplatin in Dictyostelium. Microbiology 146: 2219-2227. (Featured in Microbiology
Today 27: 203 (2000))
Srinivasan, S., Alexander, H. and Alexander, S. (2000). The Dictyostelium fruiting body - a structure of
cells and cellulose. Trends in Cell Biol 10: 315.
Srinivasan, S., Alexander, H. and Alexander, S. (2000). Crossing the finish line of development: regulated
secretion of Dictyostelium proteins. Trends Cell Biol 10: 215-219.
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Barth, C., Greferath, U., Kotsifas, M., Tanaka, Y., Alexander, S., Alexander, H. and Fisher, P. R. (2001).
Transcript mapping and processing of mitochondrial RNA in Dictyostelium discoideum. Current Genetics
39: 355-364.
Li, G., Foote, C., Alexander, S. and Alexander, H. (2001). Sphingosine-1-phosphate lyase has a central role
in the development of Dictyostelium discoideum. Development 128: 3473-3483.
Srinivasan, S., Traini, M., Herbert, B., Sexton, D., Harry, J., Alexander, H., Williams, K. L. and Alexander,
S. (2001). Proteomic analysis of a developmentally regulated secretory vesicle. Proteomics 1: 1119-1127.
Garcia, M. X. U., Roberts, C., Alexander, H., Stewart, A. M., Harwood, A., H., A. and Insall, R. H. (2002).
Methanol and acriflavine resistance in Dictyostelium are caused by loss of catalase. Microbiology 148:
333-340.
Alexander, H., Vomund, A.N., and Alexander, S. (2003a). Viability assay for Dictyostelium for use in drug
studies. Biotechniques 35: 464-466, 468, 470. (FEATURED ARTICLE)
Alexander, S., Srinivasan, S., and Alexander, H. (2003b). Proteomics opens doors to the mechanisms of
developmentally regulated secretion. Mol Cell Proteomics 2: 1156-1163. (COVER ARTICLE)
Garcia, M.X., Alexander, H., Mahadeo, D., Cotter, D.A., and Alexander, S. (2003). The Dictyostelium
discoideum prespore-specific catalase B functions to control late development and to protect spore
viability. Biochim Biophys Acta 1641: 55-64.
Alexander, H., Stegner, A.L., Wagner-Mann, C., Du Bois, G.C., Alexander, S., and Sauter, E.R. (2004).
Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid. Clin Cancer Res 10:
7500-7510.
Kumar, A., Wessels, D., Daniels, K.J., Alexander, H., Alexander, S., and Soll, D.R. (2004). Sphingosine-1phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium
discoideum cell migration and chemotaxis. Cell Motil Cytoskeleton 59: 227-241.
Min, J., Stegner, A.L., Alexander, H., and Alexander, S. (2004). Overexpression of sphingosine-1phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective
increase in sensitivity to platinum-based chemotherapy drugs. Eukaryot Cell 3: 795-805.
Min, J., Traynor, D., Stegner, A.L., Zhang, L., Hanigan, M.H., Alexander, H., and Alexander, S. (2005a).
Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug
cisplatin. Eukaryot Cell 4: 178-189.
Min, J., Van Veldhoven, P.P., Zhang, L., Hanigan, M.H., Alexander, H., and Alexander, S. (2005b).
Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38dependent manner. Mol Cancer Res 3: 287-296.
Alexander, S., Min, J., and Alexander, H. (2006). Dictyostelium discoideum to human cells:
pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance. Biochim Biophys Acta
1760: 301-309. Epub. December 22, 2005.
Min, J., Sridevi, P., Alexander, S., and Alexander, H. (2006). Sensitive cell viability assay for use in drug
screens and for studying the mechanism of action of drugs in Dictyostelium discoideum. Biotechniques
41: 591-595. Epub. October 1, 2006. (Chosen for early on-line publication and FEATURED
ARTICLE)
Williams, R.S., Boeckeler, K., Graf, R., Muller-Taubenberger, A., Li, Z., Isberg, R.R., Wessels, D., Soll,
D.R., Alexander, H., and Alexander, S. (2006). Towards a molecular understanding of human diseases
using Dictyostelium discoideum. Trends Mol Med 12: 415-424. Epub. August 4, 2006.
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McCaw, D. L., Chan, A.S., Stegner, A.L., Mooney, B., Bryan, J.N, Turquist, S.E., Henry, C.J., Alexander,
H., and Alexander, S. (2007) Proteomics of canine lymphoma identifies potential cancer specific protein
markers. Clin Cancer Res 13: 2496-2503.
Min, J., Mesika, A., Sivaguru, M., Van Veldhoven, P.P., Alexander, H., Futerman, A.H., and Alexander, S.
(2007) (Dihydro)ceramide Synthase 1–regulated sensitivity to cisplatin is associated with the activation of
p38 MAP kinase and is abrogated by sphingosine kinase 1. Mol Cancer Res 5: 801-812. (COVER
ARTICLE)
Van Driessche, N., Alexander, H., Min, J., Kuspa, A., Alexander, S., and Shaulsky, G. (2007) Global
transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets. Proc
Natl Acad Sci USA 104(39) 15406-11.
Sridevi, P., Alexander, H., Laviad, E.L., Pewzner-Jung, Y., Hannink, M., Futerman, A.H., Alexander, S.
(2009) Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochem. Biophys. Acta,
1793: 1218-1227.
Sridevi, P., Alexander, H., Laviad, E.L., Min, J., Mesika, A., Hannink, M., Futerman, A.H., Alexander, S.
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.
(2010), Exp. Cell Res. 316, 78-91. epub. October 2, 2009.
Alexander, H. and Abell, S. (2010) Intergenerational interaction rewards both sides. Journal of
Intergenerational Relationships. 8: 79-82.
OTHER PUBLICATIONS
Alexander, H. Synthetic Peptides in Biological Research. Molecular Biology Newsletter-Technical Tip
February, 1992.
Alexander, H. and Alexander, S. Slime molds, flies and your health. Columbia Missourian. April 20,
2000.
Alexander, H., Walker, John. and Alexander, S. Proteomics hits the post-genomic era running. Molecular
Biology Newsletter-Technical Tips. 2002.
PATENTS
Moriarty, A. M., Alexander, H., Lerner, R. A. (1988) SV40 expression vector containing HBxAg as an
expression marker. US Patent 4777,240
Moriarty, A. M., Alexander, H., Lerner, R. A. (1996) Antibodies, diagnostic systems and methods for
assaying HBxAg. US Patent 5,534,405
Alexander, H. and Alexander, S. (2004). Methods of screening novel agents for use in cancer therapy and
prevention. US Patent 6,746,843; (2005) US Patent 6,867,034; (2006) Australian Patent 2001284666.
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