Appendix 2: List of excluded articles 1. Ali ME, Albar HM. Measles in pregnancy: maternal morbidity and perinatal outcome. Int J Gynaecol Obstet. 1997;59:109-113. 2. Bakali-el Kassimi A, Achour M, Oudghiri A, Saoura A, Chaoui A. Management of fever during pregnancy [French]. Maroc Med. 1985;7:604-611. 3. Botto LD, Erickson JD, Mulinare J, Lynberg MC, Liu Y. Maternal fever, multivitamin use, and selected birth defects: evidence of interaction? Epidemiology. 2002;13:485-488. 4. Chemla JP, Jannet D, Milliez J. Fever in pregnancy [French]. Rev Prat. 1995;45:15551560. 5. Dietzel F, Vahrson H, Kern W. Fever as a cause of abortion [German]. Med Klin. 1972;67:387-390. 6. Erickson JD. Risk factors for birth defects: data from the Atlanta Birth Defects CaseControl Study. Teratol. 1991;43:41-51. 7. Fraser FC, Skelton J. Possible teratogenicity of maternal fever [letter]. Lancet. 1978;2:634. 8. Gericke GS, Isaacs H. An association between certain congenital abnormalities and the malignant hyperthermia trait. S Afr Med J. 1990;77:570-574. 9. Hirayama Y, Suzuki H, Arima M. Maternal hyperthermia during pregnancy in severely multi-disabled children [Japanese]. No To Hattatsu. 1992;24:559-564. 10. Hunter AG. Neural tube defects in Eastern Ontario and Western Quebec: demography and family data. Am J Med Genet. 1984;19:45-63. 11. Isaacs H, Gericke G. Concurrence of malignant hyperthermia and congenital abnormalities. Muscle Nerve. 1990;13:915-917. 12. Ivarsson SA, Henriksson P. Septic shock and hyperthermia as possible teratogenic factors. Acta Paediatr Scand. 1984;73:875-876. 13. Kline J, Stein Z, Susser M, Warburton D. Fever during pregnancy and spontaneous abortion. Am J Epidemiol. 1985;121:832-842. 14. Larsson LT, Okmian L, Kristoffersson U. No correlation between hyperthermia during pregnancy and Hirschsprung disease in the offspring. Am J Med Genet. 1989;32:260-261. 15. Layde PM, Edmonds LD, Erickson JD. Maternal fever and neural tube defects. Teratol. 1980;21:105-108. 16. Lipson A. Hirschsprung disease in the offspring of mothers exposed to hyperthermia during pregnancy. Am J Med Genet. 1988;29:117-124. 17. McDonald AD. Maternal health and congenital defect; a prospective investigation. N Engl J Med. 1958;258:767-773. 18. Mehes K. Teratogenic effect of hyperthermia [Hungarian]. Orv Hetil. 1979;120:2493-2494. 19. Piquet P, Engelmann P. Fever and pregnancy [French]. Soins. 1982;3-6. 20. Pleet H, Graham JM, Jr., Smith DW. Central nervous system and facial defects associated with maternal hyperthermia at four to 14 weeks' gestation. Pediatrics. 1981;67:785-789. 21. Pleet HB, Graham JM, Jr., Harvey MA, Smith DW. Patterns of malformation resulting from the teratogenic effects of first trimester hyperthermia [abstract]. Pediatr Res. 1980;14:587. 22. Ruscillo MM. Fever and pregnancy [French]. Soins Gynecol Obstet Pueric Pediatr. 1993;47-48. 23. Saxen L, Holmberg PC, Nurminen M, Kuosma E. Sauna and congenital defects. Teratol. 1982;25:309-313. 24. Smith DW, Clarren SK, Harvey MA. Hyperthermia as a possible teratogenic agent. J Pediatr. 1978;92:878-883. 25. Smith MS, Upfold JB, Edwards MJ, Shiota K, Cawdell-Smith J. The induction of neural tube defects by maternal hyperthermia: a comparison of the guinea-pig and human. Neuropathol Appl Neurobiol. 1992;18:71-80. 26. Tikkanen J, Heinonen OP. Maternal hyperthermia during pregnancy and cardiovascular malformations in the offspring. Eur J Epidemiol. 1991;7:628-635. 27. Uhari M, Mustonen A, Kouvalainen K. Sauna habits of Finnish women during pregnancy. Br Med J. 1979;1:1216.