ETM 4 December 2014
ETMRC (2014) 3rd Meeting
Scottish Government Health Directorates
Chief Scientist Office
Experimental and Translational Medicine Research Committee
Minute of the meeting of the ETMRC on 4 December 2014 held in Conference Rooms
A&B, St Andrew’s House, Edinburgh, at 9:30 am.
Present:
Professor Elaina Collie-Duguid
Professor Eleanor Davies
Professor Sarah Howie
Dr Faisel Khan
Professor Alistair Leanord
Dr Andrew McIntosh
Professor Alisdair MacLullich
Dr Simon Powis
Dr Russell Petty
Professor Philip Rowe
Professor Donald Salter
Professor Calum Sutherland
Scottish Government:
Dr Alan McNair
Dr Tom Barlow
Ms Diane Brockie
Ms Barbara Lamb (Lay Member)
Ms Joanna McGregor (Lay Member)
Dr Carl Goodyear (Observer)
1.
Apologies for absence and intimations
Professor Siddarthan Chandran, Professor Fiona Denison and Professor Keith
Muir.
2.
Approval of minutes of ETMRC meeting held on 6 June 2014
The minutes of the meeting were approved.
3.
Matters arising from the ETMRC meeting held on 4 December 2014 full details of the 8 successful applications from the meeting are attached at
Annex A.
4.
Final Reports
4.1
Professor Heather Cubie, NHS Lothian (CZB/4/658)
Long-Term Follow-Up Of HPV Vaccination In Women Attending First Cervical
Smear - Role And Development Of HPV Testing
Speakers – Davies – Petty - McIntosh
1
ETM 4 December 2014
The Committee graded the as report as Excellent
4.2
Professor Ian Reid, University of Aberdeen (ETM/6)
The Use Of Ketamine As An Anaesthetic During Electroconvulsive Therapy
(ECT) For Depression: Does It Improve Treatment Outcome?
Speakers – McIntosh – Denison – Rowe
The Committee graded the as report as Good
4.3
Mr Grant Stewart, University of Edinburgh (ETM/37)
Scottish Collaboration On Translational Research into Renal Cell Cancer
(SCOTRRCC): Proteomic Reconstruction Of Molecular Pathways To Predict
Renal Cell Cancer Recurrence And Response To Treatment.
Speakers - Petty – Collie-Duguid - Salter
The Committee graded the as report as Good
4.4
Dr Duncan Porter, NHS Greater Glasgow (ETM/40)
Scottish Early Rheumatoid Arthritis (SERA) Bio-Bank From An Inception Cohort
Of Patients With Newly Diagnosed Rheumatoid Arthritis
Speakers – Sutherland – Howie - MacLullich
The Committee graded the as report as Excellent
4.5
Dr Russell Petty, University of Aberdeen (ETM/116)
Qualification of Predictive Biomarkers for Epidermal Growth Factor Receptor
Tyrosine Kinase Inhibitor Therapy in Oesophagogastric Carcinoma
(Translational Cancer Oesophagus Gefitinib Study- TRANSCOG)
Speakers – MacLullich – Howie - Salter
The Committee graded the as report as Excellent
4.6
Professor Christian Schwarzbauer, University of Aberdeen (ETM/127)
Quantitative Neuroimaging In Disorders Of Consciousness Caused By Acquired
Brain Injury
Speakers – Muir – McIntosh – Howie
2
ETM 4 December 2014
The Committee graded the as report as Good
4.7
Professor Sarah Howie, University of Edinburgh (ETM/145)
Cervical HPV Infection In Vaccinated And Unvaccinated Women– New Markers
Of Infection, Immunity And Disease.
Speakers – Collie-Duguid – Chandran - Khan
The Committee graded the as report as Good
4.8
Dr Nik Hirani, University of Edinburgh (ETM/153)
Characterisation And Modulation Of Monocyte/Macrophage Lineage Cells In
Idiopathic Pulmonary Fibrosis
Speakers – Khan– Rowe – Davies
The Committee graded the as report as Good
4.9
Dr John Plevris, University of Edinburgh (ETM/182)
Tissue Engineering Of 3D Human Hepatic Organotypic Model Using Novel Cell
Biomatrix And Brioreactor Enabling Technologies For Pharmaceutical
Applications.
Speakers – Rowe – Salter - Sutherland
The Committee graded the as report as Excellent
4.10
Dr Marie Boyd, University of Strathclyde (ETM/194)
Investigations Of Very High Energy Electron Tumour Therapy Based On LaserPlasma Wakefield Accelerators
Speakers – Salter – Petty - Muir
The Committee graded the as report as Good
4.11
Professor Peter Ghazal, University of Edinburgh (ETM/202)
High Accuracy, Low Volume Host-Directed Detection Of Neonatal Sepsis
Speakers – Leanord – Collie-Duguid - Khan
The Committee graded the as report as Good
3
ETM 4 December 2014
4.12
Dr David Griffith, University of Edinburgh (ETM/221)
Persisting Inflammation Following Critical Illness: Prevalence, Relationship To
Physical Recovery, And Exploration Of Defects In Inflammatory Resolution
Pathways.
Speakers – Chandran – MacLullich - Denison
The Committee graded the as report as Good
4.13
Dr Kate Templeton, NHS Lothian (ETM/250)
MICAP: Microbiological Investigation of Community Acquired Pneumonia
Speakers –Leanord – Collie-Duguid - Denison
The Committee graded the as report as Good
5.
Applications
5.1
Professor Iain McEwan. University of Aberdeen (ETM/382)
Antiandrogen Therapy In Prostate Cancer: Impact Of Auto-Regulation Of The
Androgen Receptor Gene And Receptor Point Mutations.
Speakers – Davies – Sutherland - Howie
The committee recommended funding for this project
5.2
Professor Kenneth McColl, Dr James Going.
University of Glasgow (ETM/385)
H. Pylori Infection And Acid Secretory Function Of Entire Gastric Mucosa And Of
Mucosa Close To The Gastroesophageal Junction In Healthy Volunteers
Speakers – Salter – Petty – McIntosh
The committee did not recommend funding for this project
5.3
Dr Peter Barlow, Dr Craig Stevens. Napier University (ETM/389)
Cathelicidins As Novel Therapeutic Antiviral Agents In Rhinovirus Infection
Speakers – Howie – Chandran - Leanord
4
ETM 4 December 2014
The committee recommended funding for this project
5.4
Dr Edmund Chan,Professor Hing Leung.
University of Strathclyde (ETM/393)
Defining The Biomarker Potential And Downstream Transcriptional Signature Of
Nuclear Receptor Binding Proteins In Prostate Cancer
Speakers – Sutherland – Petty – Collie-Duguid
The committee did not recommend funding for this project
5.5
Dr Elaine Nimmo, Professor Jack Satsangi, Professor David Wilson.
University of Edinburgh (ETM/395)
Characterisation Of Genetic And Epigenetic Alterations In The VMP1/Mir21
Region In Crohn's Disease - Implications For Pathogenesis And Translation To
Clinical Application
Speakers – MacLullich – Khan – Howie
The committee recommended funding for this project
5.6
Professor David Fitzpatrick, Dr Hemant Bangani, Dr Andrew Wood.
University of Edinburgh (ETM/396)
Assessing The Potential Of Crispr/Cas9 Genome Editing Technology For Ex
Vivo And In Vivo Therapeutic Correction Using Phenylketonuria As A Model
Speakers – Collie-Duguid – Muir - Sutherland
The committee did not recommend funding for this project
5.7
Dr Calum Sutherland, Dr Ashleigh Duthie, Professor Simon Lovestone,
Professor John Geddes. University of Dundee (ETM/401)
Preliminary Evaluation Of The Therapeutic Potential Of Lithium In Mild Cognitive
Impairment
Speakers – MacLullich – McIntosh – Muir
The committee recommended funding for this project
5
ETM 4 December 2014
5.8
Professor James Scobbie, Dr Joanne Cleland.
Queen Margaret University (ETM/402)
Ultrasound Visual Biofeedback Treatment For Speech Sound Disorders In
Children
Speakers – Denison – Howie - Salter
The committee recommended funding for this project
5.9
Professor George MacFarlane, Dr Nigel Reynolds.
University of Dundee (ETM/403)
Resistant Starch And Non-Starch Polysaccharide (Dietary Fibre) Intake In
Relation To The Structure And Metabolic Activities Of The Colonic Microbiome
In Older People
Speakers – MacLullich – Leanord – Chandran
The committee recommended funding for this project
5.10
Professor Anthony Chalmers, Dr Natividad Gomez-Roman
University of Glasgow (ETM/405)
Mitochondrial Poisoning As A Novel Strategy To Overcome Radiation
Resistance Of Glioblastoma
Speakers – Petty – Salter - Chandran
The committee recommended funding for this project
5.11
Dr Dana Dawson, Dr Ornella Rimoldi, Professor Andy Welch, Professor
Matteo Zanda, Professor Michael Frenneaux. University of Aberdeen
(ETM/409)
Metabolic Pathways In Acute Stress Induced (Tako-Tsubo) Cardiomyopathy
Speakers – Khan – Davies – Chandran
The committee did not recommend funding for this project
5.12
Dr Stefan Siebert, Professor Iain McInnes, Professor Stuart Ralston,
Dr Neil Basu, Professor Ian Ford, Dr Neil McKay University of Glasgow
(ETM/414)
Towards A Predictive Molecular Taxonomy For Psoriatic Arthritis
Speakers – Salter – Chandran – MacLullich
The committee recommended funding for this project
6
ETM 4 December 2014
5.13
Dr Veronique Vitart, Dr Danny Mitry, Mr David Charteris,
Professor Harry Campbell, Dr Aman Chandra University of Edinburgh
(ETM/416)
Geneic Study Of Primary Rhematogenous Retinal Detachment: Building On The
Scottish National Study Resource
Speakers – Collie-Duguid – McIntosh - Sutherland
The committee did not recommend funding for this project
6.
Any other business
7.
Date of next meeting
Friday 5 June 2015, conference rooms A&B, St. Andrew’s House, Edinburgh,
9:30 am.
Annex A
Matters arising from the minutes of the ETMRC meeting held on 4 December
2014
3.1
Professor Iain McEwan. University of Aberdeen (ETM/382)
Antiandrogen Therapy In Prostate Cancer: Impact Of Auto-Regulation Of The
Androgen Receptor Gene And Receptor Point Mutations.
.
A funding letter has now been issued.
Start 01/03/2015
2015-16
2016-17
11,396
110,363
3.2
Completion 28/02/17
2017-18
Total
99,025
220,784
Dr Peter Barlow, Dr Craig Stevens. Napier University (ETM/389)
Cathelicidins As Novel Therapeutic Antiviral Agents In Rhinovirus Infection
A funding letter has now been issued.
Start 01/05/2015
2015-16
2016-17
76,294
81,136
Completion 30/04/2017
2017-18
Total
5,722
163,152
7
ETM 4 December 2014
3.3.
Dr Elaine Nimmo, Professor Jack Satsangi, Professor David Wilson.
University of Edinburgh (ETM/395)
Characterisation Of Genetic And Epigenetic Alterations In The VMP1/Mir21
Region In Crohn's Disease - Implications For Pathogenesis And Translation To
Clinical Application
.
A funding letter has now been issued.
Start 01/03/2015
2015-16
2016-17
35,581
94,290
3.4.
Completion 31/08/2017
2017-18
Total
95,127
224,998
Dr Calum Sutherland, Dr Ashleigh Duthie, Professor Simon Lovestone,
Professor John Geddes. University of Dundee (ETM/401)
Preliminary Evaluation Of The Therapeutic Potential Of Lithium In Mild Cognitive
Impairment
A funding letter has now been issued.
Start 01/04/2015
2015-16
Total
113,793
113,793
3.5
Completion 31/03/2016
Professor James Scobbie, Dr Joanne Cleland.
Queen Margaret University (ETM/402)
Ultrasound Visual Biofeedback Treatment For Speech Sound Disorders In
Children.
A funding letter has now been issued.
Start 01/04/2015
2015-16
2016-17
93,217
45,206
3.6
Completion 30/09/2016
Total
138,423
Professor George MacFarlane, Dr Nigel Reynolds.
University of Dundee (ETM/403)
Resistant Starch And Non-Starch Polysaccharide (Dietary Fibre) Intake In
Relation To The Structure And Metabolic Activities Of The Colonic Microbiome
In Older People
A funding letter has now been issued.
Start 01-02-2015
Completion 31-01-2017
8
ETM 4 December 2014
2015-16
18,247
3.7
2016-17
112,400
2017-18
93,736
Total
224,383
Professor Anthony Chalmers, Dr Natividad Gomez-Roman
University of Glasgow (ETM/405)
Mitochondrial Poisoning As A Novel Strategy To Overcome Radiation
Resistance Of Glioblastoma
A funding letter has now been issued.
Start 01-02-2015
2015-16
2016-17
62,365
88,335
3.8
Completion 31-01-2017
2017-18
Total
74,573
225,273
Dr Stefan Siebert, Professor Iain McInnes, Professor Stuart Ralston,
Dr Neil Basu, Professor Ian Ford, Dr Neil McKay University of Glasgow
(ETM/414)
Towards A Predictive Molecular Taxonomy For Psoriatic Arthritis
A funding letter has now been issued.
Start 01-04-2015
2015-16
2016-17
75,549
75,549
Completion 31-03-2018
2017-18
Total
75,549
226,647
9