ETM 6 June 2014
ETMRC (2014) 2nd Meeting
Scottish Government Health Directorates
Chief Scientist Office
Experimental and Translational Medicine Research Committee
Minute of the meeting of the ETMRC on 6 June 2014 held in Conference Rooms A&B,
St Andrew’s House, Edinburgh, at 9:30 am.
Present:
Professor Eleanor Davies
Dr Fiona Denison
Professor Ruth Jarrett
Professor Alistair Leanord
Dr Andrew McIntosh
Professor Keith Muir
Dr Russell Petty
Professor Philip Rowe
Professor Donald Salter
Scottish Government:
Dr Alan McNair
Ms Diane Brockie
Mr Michael McLeod
Ms Barbara Lamb (Lay Member)
Ms Joanna McGregor (Lay Member)
1.
Apologies for absence and intimations
Professor Siddarthan Chandran, Dr Elaina Collie-Duguid, Dr Faisel Khan
Professor Sarah Howie, Professor Alasdair MacLullich Dr Calum Sutherland
and Dr Simon Powis sent their apologies.
2.
Approval of minutes of ETMRC meeting held on 27 December 2013
The minutes of the meeting were approved.
3.
Matters arising from the ETMRC meeting held on 6 June 2014 full details of the 7 successful applications from the meeting are attached at
Annex A.
4.
Final Reports
4.1
Dr Philip Leonard Riches, University of Edinburgh (ETM/46)
Do neutralising antibodies to osteoprotegerin explain the association between
cardiovascular disease and osteoporosis.
Speakers – Sutherland / MacLullich / Denison
The Committee graded the as report as Satisfactory
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ETM 6 June 2014
4.2
Professor Helen Colhoun, University of Dundee (ETM/47)
Scottish diabetes research network type1 diabetes bioresource.
Speakers – Davies / McIntosh / Chandran
The Committee graded the as report as Good
4.3
Dr A.J.E Green (ETM/58)
Development and evaluation of a disease-specific diagnostic test for CreutzfeldtJakob disease based on the detection of PrP in the cerebrospinal fluid using
real-time QuIC analysis.
Speakers – Collie-Duguid / Khan / Petty
The Committee graded the as report as Good
4.4
Professor Rob Mairs, University of Glasgow (ETM/60)
Evaluation of melanin-targeted radiotherapy in combination with cytotoxic drugs
and the role of bystander effects in the treatment of melanoma.
Speakers –Petty / Howie / Salter
The Committee graded the as report as Good
4.5
Professor Adriano Rossi, University of Edinburgh (ETM/86)
Augmenting human eosinophil apoptosis; the role of cyclin-dependent kinase
inhibitors
Speakers – Collie-Duguid / Leanord / Davies
CSO is working with the PI to resolve the issues if possible
4.6
Professor G. Graham (ETM/115)
Assessing the value and function of D6 as a novel marker of inflammatory
diseases.
Speakers – Collie-Duguid / MacLullich / Sutherland
CSO is working with the PI to resolve the issues if possible
4.7
Professor David Newby, University of Edinburgh(ETM/160)
Novel imaging approaches to identify unstable coronary plaques.
Speakers – Khan / Muir / Rowe
The Committee graded the as report as Excellent
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ETM 6 June 2014
5.
Applications
5.1
Professor Allan D. Struthers, Professor Rory McCrimmon, Professor Chim
Lang, Dr Eleanor Dow. University of Dundee / NHS Tayside (ETM/352)
Moving towards a new personalised medicine approach to primary prevention in
diabetes: The first steps.
Speakers – Muir / Chandran / McIntosh
The committee recommended funding for this project
5.2
Dr Monika Harvey, Professor Keith Muir, Dr Marie-Helene Grosbras,
Professor Matthew Walters. NHS Greater Glasgow & Clyde (ETM/353)
Non-invasive brain stimulation in stroke patients.
Speakers – Rowe / McIntosh / MacLullich
The committee recommended funding for this project
5.3
Professor Helen Galley, Professor Nigel Webster, Professor John Norrie,
Dr Lorna Aucott, Dr Damon Lowes. University of Aberdeen / NHS Grampian
(ETM/358)
A pilot study of oral melatonin in patients with sepsis
Speakers – Leanord / Howie / Khan
The committee recommended funding for this project
5.4
Professor Kamil R. Kranc, Patrick J. Pollard. University of Edinburgh
(ETM/362)
Targeting metabolism to eradicate human leukaemic stem cells.
Speakers – Petty / Howie / Salter
The committee did not recommend funding for this project
5.5
Dr Malcolm John Watson, Dr Alex McConnachie, Dr Alison Wood. NHS
Greater Glasgow and Clyde (ETM/364)
A project to determine the dose of levobupivacaine required to provide greater
than 12 hours of pain relief for patients with a fractured hip.
Speakers – MacLullich / Denison / Salter
The committee did not recommend funding for this project
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ETM 6 June 2014
5.6
Jennifer Robson, David Newby, Marc Dweck, Edwin van Beek, Graeme
Weir, Alex Vesey. University of Edinburgh / NHS Lothian (ETM/365)
18F-sodium fluoride imaging of abdominal aortic aneurysms.
Speakers – Muir / MacLullich / Leanord
The committee recommended funding for this project
5.7
Nicholas Reid Leslie, Rafael Pulido. Heriot Watt University (ETM/371)
Optimising PTEN-long for use as a biologic cancer therapy.
Speakers – Howie / Davies / Khan
The committee did not recommend funding for this project
5.8
Dr Christina Halsey, Professor Eyal Gottlieb, Dr Pawel Herzyk. University of
Glasgow (ETM/374)
Identifying novel targets for eradication of acute lymphoblastic leukaemia in the
central nervous system.
Speakers – Chandran / Petty / Denison
The committee recommended funding for this project
5.9
Professor Anita J Simmers, Professor Dennis Levi, Ms Heather Murray, Dr
Richard Harrad. Glasgow Caledonian University (ETM/375)
Perceptual learning in enhanced amblyopia treatment (PLEAT): an exploratory
randomised control trial in the treatment of amblyopia.
Speakers – Denison / McIntosh / Rowe
The committee recommended funding for this project
5.10
Professor Mihalis Panagiotidis, Dr. George Goussetis, Professor Marc
Philip Yves Desmulliez, Dr Ewan R S Brown. Heriot-Watt University
(ETM/377)
Turn the heat on malignant melanoma: novel insights of microwave-induced
hyperthermia in promoting therapeutic effectiveness
Speakers - Leanord / Chandran / Khan
The committee did not recommend funding for this project
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ETM 6 June 2014
5.11
Dr Stelios Psycharakis, Dr Simon Coleman, Ms Linda Linton, Dr
Konstantinos Kaliarntas. Edinburgh Napier University (ETM/378)
The WATER project: Which AquaTic ExeRcises work best? Identifying muscle
recruitment for aquatic exercises used in interventions for core strengthening
and rehabilitation from musculoskeletal disorders.
Speakers – Rowe / Salter / Howie
The committee recommended funding for this project
6.
Any other business
7.
Date of next meeting
Thursday 4 December 2014, conference rooms A&B, St. Andrew’s House,
Edinburgh, 9:30 am.
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ETM 6 June 2014
Annex A
Matters arising from the minutes of the ETMRC meeting held on 6 June 2014
3.1
Dr Monika Harvey, Professor Keith Muir, Dr Marie-Helene Grosbras,
Professor Matthew Walters. NHS Greater Glasgow & Clyde (ETM/353)
Non-invasive brain stimulation in stroke patients.
A funding letter has now been issued.
Start 01/07/2014
2014-15
2015-16
69,328
91,850
3.2
Completion 30/11/16
2016-17
2017-18
53,875
5,298
Total
220,351
Professor Helen Galley, Professor Nigel Webster, Professor John Norrie,
Dr Lorna Aucott, Dr Damon Lowes. University of Aberdeen / NHS Grampian
(ETM/358)
A pilot study of oral melatonin in patients with sepsis
A funding letter has now been issued.
Start 01/10/2014
2014-15
2015-16
81,503
90,588
3.3.
Completion 30/09/2016
2016-17
Total
52,485
224,576
Jennifer Robson, David Newby, Marc Dweck, Edwin van Beek, Graeme
Weir, Alex Vesey. University of Edinburgh / NHS Lothian (ETM/365)
18F-sodium fluoride imaging of abdominal aortic aneurysms.
A funding letter has now been issued.
Start 01/07/2014
2014-15
2015-16
50,850
68,370
3.4.
Completion 30/06/2017
2016-17
2017-18
69,170
17,327
Total
205,747
Dr Christina Halsey, Professor Eyal Gottlieb, Dr Pawel Herzyk. University of
Glasgow (ETM/374)
Identifying novel targets for eradication of acute lymphoblastic leukaemia in the
central nervous system.
A funding letter has now been issued.
Start 01/11/2014
2014-15
2015-16
56,621
110,103
Completion 30/10/2016
2016-17
Total
57,050
223,774
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ETM 6 June 2014
3.5
Professor Anita J Simmers, Professor Dennis Levi, Ms Heather Murray, Dr
Richard Harrad. Glasgow Caledonian University (ETM/375)
Perceptual learning in enhanced amblyopia treatment (PLEAT): an exploratory
randomised control trial in the treatment of amblyopia.
A funding letter has now been issued.
Start 01/09/2014
2014-15
2015-16
73,108
108,972
3.6
Completion 31/08/2016
2016-17
Total
42262
224,342
Dr Stelios Psycharakis, Dr Simon Coleman, Ms Linda Linton, Dr
Konstantinos Kaliarntas. Edinburgh Napier University (ETM/378)
The WATER project: Which AquaTic ExeRcises work best? Identifying muscle
recruitment for aquatic exercises used in interventions for core strengthening
and rehabilitation from musculoskeletal disorders.
A funding letter has now been issued.
Start 01-10-2014
2014-15
2015-16
55,714
109,387
3.7
Completion 31-09-2016
2016-17
Total
78,581
24,3682
Professor Allan D. Struthers, Professor Rory McCrimmon, Professor Chim
Lang, Dr Eleanor Dow. University of Dundee / NHS Tayside (ETM/352)
Moving towards a new personalised medicine approach to primary prevention in
diabetes: The first steps.
Start 01-08-2014
2014-15
2015-16
79,940
120,270
Completion 31-05-2016
2016-17
Total
20,244
220,454
A funding letter has now been issued.
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