Saturday, July 7, 2006
10:00 AM Registration of the participants
05:00 PM
02:00 PM E.C.A. Permanent Working Groups
Co-ordinator: E. Blennow
02:00-03:00 Prenatal Diagnosis - Dolmabahçe A
Cytogenetics of Germ Cells, Pre-Implantation Cytogenetic Studies –
Dolmabahçe B
European Association of Cytogenetic Technologists EATC - Dolmabahçe C
Eurogentest: European Cytogenetic National Representatives Meeting
(by invitation only) - Press room
03:00-04:00 Cancer Cytogenetics, Solid Tumor Studies - Dolmabahçe A
Clinical and Molecular Approach of Cytogenetic Syndromes - Dolmabahçe B
Marker Chromosomes - Dolmabahçe C
Genetic Testing in Europe: A network for test development, harmonisation, validation and standardisation - Pressroom .
04:00-05:00 Cytogenetic Toxicology and Mutagenesis - Dolmabahçe A
Molecular Cytogenetics and Array CGH - Dolmabahçe B
Meiotic Studies - Dolmabahçe C
Cytogenetics and Society - Pressroom
05:00-06:00 Applied Imaging International Satellite Symposium – Haliç
06:30 PM Opening ceremony – Anadolu Auditorium
Chaired by L. Larizza
A. Schinzel: How human chromosome aberrations are formed.
07:30 PM Transfer to the welcome receptıon at Istanbul Unıversıty rectorat
08:00 PM Welcome Reception.
Sunday, July 8, 2006
08:30 AM Plenary sessions
Clinical cytogenetics I - Anadolu Auditorium (400)
Chaired by K. Madan, G. Lüleci
W. Bickmore: Nuclear organisation of chromatin and human disease.
K.H. Ørstavik: Skewed X-inactivation and human disease.
G. van Buggenhout: Chromosome aberrations in ageing mentally retarded persons.
Selected abstracts
S. Van Vooren: Literature Mining for Constitutional Cytogenetics.
A. Baumer: Trisomies represent risk factors for further independent nondisjunction events.
10:30 AM Coffee break and Trade Exhibition
11:00 AM Animal cytogenetics and karyotype evolution - Anadolu Auditorium (50)
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Chaired by M. Rocchi, R. Stanyon
B. Dutrillaux: Meiosis in beetles: an example of biodiversity.
F. Yang: Comparative cytogenetics and karyotype evolution of muntjacs
(Muntiacus).
L. Iannuzzi: Animal cytogenetics and karyotype evolution in Bovids.
Selected abstract
A. Cellamare: Progression Dynamics of Evolutionary-New Centromeres.
12:30 PM Lunch
01:00-02:00 Abbott Satellite Symposium Haliç
01:30 PM Poster session no. 1
02:30 PM Concurrent sessions
Chromosome instability in constitutional pathology and cancer
- Anadolu Auditorium (200)
Chaired by L. Larizza, J.P. Bureau
M. O'Driscoll: Cellular and clinical impact of genomic haploinsufficiency for genes involved in the ATR-dependent DNA damage response signalling pathway.
W. Saunders: Centrosomal amplification and multipolarity in cancer cells.
Selected abstracts:
I. Amir: Altered allelic replication timing in microdeleted genome.
I. Demidova: Evidences for increased level of mosaic aneuploidy involving chromosome 1 in the schizophrenia brain.
Gamete chromosomes –
Topkapı A (150)
Chaired by J.M. Garcia-Sagredo
M. Garcia-Caldes: Maternal origin of human trisomy.
F. Pellestor: The study of chromosomal translocations in male gametes: segregation, interchromosomal effect and impact on fertility.
Selected abstracts:
J. Delhanty: Comprehensive analysis of human oocytes and 1st polar bodies by comparative genomic hybridisation (CGH).
E. Anton: Human reciprocal translocations: approximation to their segregation behavior using sperm FISH analysis.
04:00 PM Coffee break and Trade Exhibition
04:30 PM Concurrent sessions
New microdeletion syndromes, use of MLPA for cytogenetic diagnosis
- Anadolu Auditorium (200)
Chaired by A. Schinzel, S. Artan
B. de Vries: New microdeletion syndromes.
F. Kooy: Application of MLPA for cytogenetic diagnostics and research.
Selected abstract:
A. Delahaye: Evaluation of MLPA in routine diagnostics for the detection of subtelomeric rearrangements in 1040 patients with idiopathic mental retardation.
E. Andreucci: 6q24 duplication and transient neonatal diabetes: A possible differential diagnosis with Beckwith-Wiedemann syndrome?
Quality assessment in cytogenetics – Marmara (150)
Chaired by K. Miller, M. Alikasifoglu
U. Kristoffersson: Quality assessment and validation in clinical cytogenetic services.
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S.J. Hamilton: Quality assessment in QF-PCR for rapid aneuploidy screening:
The UK experience.
B. Quellhorst-Prawley: EQA in Europe.
05:45–06.45 Agilent Satellite Symposium - Haliç
Monday, July 9, 2006
08:30 AM Plenary sessions
Cancer cytogenetics - Anadolu Auditorium
Chaired by J. Limon, B. Young
B. Young: Linking cytogenetics to genotype analysis can uncover new events in leukaemia.
F. Speleman: Integration of molecular cytogenetics, arrayCGH and expression profiling in the study of neuroblastoma: implications for future therapy.
A. Geurts van Kessel: Cycle (de)regulation in t(X;1)(p11;q21)-positive renal cell
Cancer.
Selected abstracts :
J. Suela: Combination of different genomic approaches to define a candidate deleted gene in AML.
L. Russell: Multiple novel genes are deregulated by IGH@ in B cell precursor acute lymphoblastic leukaemia including five members of the CEBP gene family.
P. Edwards: Array painting shows a number of balanced translocations that target cancer-relevant genes in breast cancer cell lines.
A. Elliott: MLPA analysis of neuroblastoma tumours.
10:30 AM Coffee break and Trade Exhibition
10:45 AM Affymetrix Satellite Symposium –
Haliç
A. Dufke: Genomic copy number analysis using the Affymetrix 500K SNP arrays.
11:30 AM Cytogenetics, biodiversity and plant evolution in Turkey and the wider Middle East - Anadolu Auditorium (30)
Chaired by P. Heslop-Harrison
P. Heslop-Harrison: Chromosome evolution and centres of diversity of crops.
M. Ørgaard: Crocus cytogenetics, speciation and phylogeny.
A. Belyayev: Cereal Genomes and the evolution of diversity.
H. Ozkan: Genome changes and cereal ploidy.
D. Pignone: Germplasms, diversity, cytogenetics around the Mediterranean.
01:00-02:00 Ikonysis Satellite Symposium:
Ikoniscope® Robotic Microscopy in Cytogenetics and Rare Cell Detection
- Haliç
J. Wauters: Fully automated FISH examination in prenatal and bladder cancer diagnosis.
Sir W. Bodmer: Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope (Ikoniscope®).
01:30 PM Poster session no. 2
02:30 PM Concurrent sessions
Microarrays linked to cytogenetic diagnosis - Anadolu Auditorium
Chaired by J. Wolstenholme
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E. Maher: Microarrays in the diagnostic laboratory.
A. Reymond: Flanking gene expresion in microdeletion syndromes.
Selected abstracts:
R. Hochstenbach: Copy number variants complicate interpretation of pathogenic segmental aneuploidy.
N. de Leeuw: Diagnostic use of molecular karyotyping by tiling-resolution array
CGH in patients with mental retardation.
Preimplantation genetic diagnosis – Topkapı A
Chaired by E. Blennow, M. Bahce
C. Le Caignec: Application of metaphase and array CGH to preimplantation genetic diagnosis.
C. Staessen: Review: PGD for chromosomal abnormalities with FISH.
Selected abstracts:
A. Mantzouratou: Evidence for variable aneuploidy mechanisms in embryos from couples with distinct indications for preimplantaion genetic screening (PGS).
E. Vanneste: Aneuploidy and aneusomy detection in human embryos by array
CGH.
Y. Saglam: Preimplantation genetic diagnosis for HLA typing.
04:00 PM Coffee break and Trade Exhibition
04:30 PM Concurrent sessions
Clinical cytogenetics II (evolution of phenotypes) - Anadolu Auditorium
(300)
Chaired by G. Kosztolányi, A. Schinzel
G. Kosztolányi: Consequences of ring formation of human chromosomes.
E. Rossi: Array CGH findings of ring chromosomes.
Selected abstracts:
L. Backx: Array painting using microdissected chromosomes to map chromosomal breakpoints.
S. Cheung: Detection of somatic mosaicism by Targeted aCGH: Clinical experience of 5000 samples.
Architecture of the human genome - Marmara (150)
Chaired by M. Rocchi ,
E. Eichler: The evolution of human segmental duplication architecture.
G. Bernardi: Molecular basis of chromosomal bands.
P. Stankiewicz: Mechanisms of DNA rearrangements underlying genomic disorders.
M. Rocchi: Human neocentromeres and evolutionary-new centromeres.
Selected abstract:
O. Uyguner: The formation of isochromosome 12p in 8 cases with Pallister-
Killian syndrome.
06:00 PM General Assembly of the European Cytogeneticists Association – Topkapı A (100)
08:30 PM Conference Dinner
Tuesday, July 10, 2006
08:30 AM Plenary sessions
New developments in prenatal diagnosis – Anadolu Auditorium (200)
Chaired by S. Basaran, J. Vermeesch
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H. Fiegler: Array CGH in prenatal diagnosis.
J. Crolla: To quit or not to quit prenatal cytogenetic diagnosis?
M. Rodriguez de Alba: Non-invasive prenatal diagnosis.
J. Wouters: Towards automated FISH screening.
Selected abstract:
B. Faas: MLPA for prenatal aneuploidy testing: analytical validation and retrospective clinical evaluation.
10:30 AM
11:00 AM
Coffee break and Trade Exhibition
Array-CGH: New cytogenetic epidemiology, new chromosome rearrangements
- Anadolu Auditorium (300)
Chaired by A. Schinzel , O. Zuffardi
O. Zuffardi: Frequency and types of unbalanced chromosome rearrangements combining new and old data.
M.C. Bonaglia: The history of chromosome 22q distal deletions: actual frequency and related phenotype.
J. Vermeesch: “Balanced” complex rearrangements: how many are really balanced?
G. Hobson: Triplication and more than triplication rearrangements.
R. Redon: Normal copy number variation in the human genome.
01:00 PM Discussion of difficult clinical cytogenetic cases –
Topkapı B (50)
02:00 PM Closing session - Anadolu Auditorium
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