NATIONAL CANCER INSTITUTE
Postdoctoral Fellowship Opportunity
Cell Biology-Molecular Biology-Molecular Immunology
A postdoctoral fellowship position is available in the Molecular Regulation Section of the
Experimental Immunology Branch to investigate the molecular mechanisms regulating
gene transcription initiation and elongation. Using the major histocompatibility complex
(MHC) class I genes as a model, research is focused on characterizing the regulatory
pathways that govern their transcription in order to understand how class I molecules
function in immune surveillance. Research projects focus on the 1) characterization of
the transcription factors, DNA sequence elements and core promoter structure using in
vitro assays or in vivo mouse transgenic models, 2) molecular mechanisms of
transcription initiation and elongation using in vitro systems, 3) chromatin organization
and promoter organization in vivo in transgenic model systems, and 4) the role of locus
control regions and boundary elements in regulating gene expression. Experimental
approaches include standard molecular and cell biology (including sequencing, ChIP
analysis, in vitro transcription, microarrays, siRNA etc), confocal microscopy, flow
cytometry, DNA-mediated gene transfer techniques including transgenesis,
bioinformatics. In addition, the Branch provides exposure to a large scope of biological
processes (transcription, DNA repair, cell trafficking, T cell development) within the
scope of the immunological landscape
The laboratory and Branch are committed to effective and personal mentoring of all
trainees to prepare them for future careers as independent investigators. This includes
direct and frequent interactions and collaborations within the lab, Branch and other NIH
labs, participation in national/international meetings and support for FAES courses.
Program duration is 2 to 5 years. Candidates must have a Ph.D. and/or M.D. with less
than 5 years postdoctoral experience. Training/experience in either cell biology,
molecular biology or molecular immunology required. Stipend range $37,000 to $47,000
commensurate with experience. Standard self and family health insurance is provided
and high option coverage is available.
Interested candidates should submit a cover letter, resume, bibliography and three letters
of references to Dr. Dinah Singer – via email ds13@nih.gov or mail to National Cancer
Institute, 6130 Executive Blvd, Rm. 5044, Bethesda, MD 20892-8342
DHHS, NIH and NCI are EQUAL OPPORTUNITY EMPLOYERS