Robert C. Dickson
CURRICULUM VITAE
Robert Carl Dickson
I.
General Information
Business address
Dept. of Molecular and Cellular Biochemistry
University of Kentucky Medical Center
741 Limestone St.
BBSRB, Rm B173
Lexington, KY 40536
Phone: (859) 323-6052
e-mail: bobd@uky.edu
II.
Education
University of Redlands, Redlands, CA
University of California, Los Angeles, CA
III.
1961 - 1965 B.S. (Biology)
1966 - 1970 Ph.D. (Molecular Biology)
Professional Experiences
1966 - 1970 Graduate student, Molecular Biology Institute, U.C.L.A.
Dr. Frederic A. Eiserling, advisor
1970 - 1972 Postdoctoral Fellow, Division of Biology, California Institute
of Technology. Dr. William B. Wood, advisor.
1972 - 1973 Postdoctoral Fellow, Department of Bacteriology, U.C.L.A.
Dr. R. John Collier, advisor.
1973 - 1975 Postdoctoral Fellow, Department of Chemistry, University of
California, San Diego. Dr. John Abelson, advisor.
IV.
Academic Appointments
1975 - 1979
1979 - 1988
1988 - present
V.
Assistant Professor, Department of Biochemistry
University of Kentucky, Lexington, KY
Associate Professor, Department of Biochemistry
University of Kentucky, Lexington, KY
Professor, Department of Biochemistry
University of Kentucky, Lexington, KY
Honors
Graduated cum laude in Biology, University of Redlands, 1965
Ph.D. with distinction (Molecular Biology) U.C.L.A., 1970
Faculty Research Award, American Cancer Society, 1979 - 1984
University of Kentucky Research Professor, 1988 – present
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Robert C. Dickson
Faculty Research Award, UK College of Medicine, 1999
Robert L. Lester Professor of Biochemistry, 1999 - present
VI.
Research and Creative Productivity
Publications:
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Dickson, R. C., Barnes, S. L., and Eiserling, F. A. (1970) Structural proteins of
bacteriophage T4. J. Mol. Biol. 53:461-473.
Ward, S., and Dickson, R. C. (1971) Assembly of bacteriophage T4 tail fibers III.
Genetic control of the major tail fiber polypeptides. J. Mol. Biol. 62:479-492.
Eiserling, F. A., and Dickson, R. C. (1972) Assembly of Viruses. Ann. Rev.
Biochem. 41:467-501. (Review)
Wood, W. B., Dickson, R. C., Bishop, R. J., and Revel, H. R. (1972) Self-assembly
and non-self-assembly in bacteriophage T4 morphogenesis in genetic mechanisms
of development (Academic Press, New York).
Dickson, R. C. (1973) Assembly of bacteriophage T4 tail fibers. IV. Subunit
composition of tail fibers and fiber precursors. J. Mol. Biol. 79:633-647.
Dickson, R. C. (1974) Protein composition of the tail and contracted sheath of
bacteriophage T4. Virology 59:123-138.
Dickson, R. C., Abelson, J., Barnes, W. M., and Reznikoff, W. S. (1975) Genetic
Regulation: the lac control region. Science 187:27-35.
Barnes, W. M., Reznikoff, W. S., Blattner, F. R., Dickson, R. C., and Abelson, J.
(1975) The isolation of RNA homologous to the genetic control elements of the
lactose operon. J. Biol. Chem. 250:8184-8192.
Dickson, R. C., Abelson, J., Johnson, P., Barnes, W. M., and Reznikoff, W. S.
(1977) Nucleotide sequence changes produced by mutations in the lac promoter of
E. coli. J. Mol. Biol. 111:65-75.
Wood, W. B., Conley, M. P., Lyle, H. H., and Dickson, R. C. (1978) Attachment of
Tail Fibers in Bacteriophage T4 Assembly. II. Purification, properties, and site of
action of the catalytic protein 63P. J. Biol. Chem. 253:2437-2445.
Dickson, R. C., and Markin, J. S. (1978) Molecular cloning and expression in
Escherichia coli of a yeast gene coding for ß-galactosidase. Cell 15: 123-130.
Dickson, R. C., Dickson, L. R., and Markin, J. S. (1979) Purification and properties
of an inducible ß-galactosidase Isolated from the yeast Kluyveromyces lactis. J.
Bacteriol. 137:51-61.
Dickson, R. C., and Markin, J. S. (1980) Physiological studies of ß-galactosidase
induction in the yeast Kluyveromyces lactis. J. Bacteriol. 142:777-785.
Dickson, R. C. (1980) Expression of a foreign eucaryotic gene in Saccharomyces
cerevisiae: ß-galactosidase from Kluyveromyces lactis. Gene 10: 347-355.
Sheetz, R. M., and Dickson, R. C. (1980) Mutations affecting synthesis of ßgalactosidase activity in the yeast Kluyveromyces lactis. Genetics 95:877-890.
Lacy, L. R., and Dickson, R. C. (1981) Transcriptional regulation of the
Kluyveromyces lactis ß-galactosidase gene. Mol. Cell. Biol. 1:629-634.
Sheetz, R. M., and Dickson, R. C. (1981) LAC4 is the structural gene for ßgalactosidase in Kluyveromyces lactis. Genetics 98:729-745.
Dickson, R. C., Sheetz, R. M., and Lacy, L. R. (1981) Genetic regulation:
Constitutive mutants of Kluyveromyces lactis increase the level of ß-galactosidase
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mRNA. Mol. Cell. Biol. 1:1048-1056.
Dickson, R. C., and Barr, K. (1983) Characterization of lactose transport in
Kluyveromyces lactis. J. Bacteriol. 154:1245-1251.
Webster, T. D., and Dickson, R. C. (1983) Direct selection of Saccharomyces
cerevisiae resistant to the antibiotic G418 following transformation with a DNA
vector carrying the kanamycin resistance gene of Tn903. Gene 26:243-252.
Riley, M. I., and Dickson, R. C. (1984) Genetic and biochemical characterization of
the galactose gene cluster in Kluyveromyces lactis. J. Bacteriol. 158:705-712.
Sreekrishna, K., Webster, T. D., and Dickson, R. C. (1984) Transformation of
Kluyveromyces lactis with the kanamycin (G418) resistance gene of Tn903. Gene
28:73-81.
Sreekrishna, K. and Dickson, R. C. (1985) Construction of Saccharomyces
cerevisiae that grow on lactose. Proc. Natl. Acad. of Sci. USA 82:7909-7913.
Riley, M. I., Hopper, J. E. Johnston, S. A. and Dickson, R. C. (1987) GAL4 of
Saccharomyces cerevisiae activates the lactose-galactose regulon of
Kluyveromyces lactis and creates a new phenotype-glucose repression of the
regulon. Mol. and Cell. Biol. 7:780-786.
Wray, L. V., Jr., Witte, M. M. Dickson, R. C. and Riley, M. I. (1987) Characterization
of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose
regulon of Kluyveromyces lactis: Structural and functional relationships to GAL4 of
Saccharomyces cerevisiae. Mol. and Cell Biol. 7:111-1121.
Riley, M. I., Sreekrishna, K., Bhairi, S. and Dickson, R. C. (1987) Isolation and
characterization of mutants of Kluyveromyces lactis defective in lactose transport.
Molec. Gen. Genetics 208:145-151.
Marek, E. T. and Dickson, R. C. (1987) Cloning and characterization of yeast genes
that confer methionine sulfoximine and tabtoxin resistance on Saccharomyces
cerevisiae. J. Bacteriol. 169:2440-2448.
Leonardo, J., Bhairi, S. and Dickson, R. C. (1987) Identification of an upstream
activator sequence that regulates induction of the ß-galactosidase gene in
Kluyveromyces lactis. Mol. and Cell. Biol. 7:4369-4376.
Webster, T. D. and Dickson, R. C. (1988) The organization and transcription of the
galactose gene cluster of Kluyveromyces lactis. Nuc. Acids Res. 16:8011-8028.
Webster, T. D. and Dickson, R. C. (1988) Nucleotide sequence of the galactose
gene cluster of Kluyveromyces lactis. Nuc. Acids Res. 16:8192-8194.
Chang, Y. D. and Dickson, R. C. (1988) primary structure of the lactose permease
gene of Kluyveromyces lactis. J. Biol. Chem. 263:16696-16703.
Witte, M. M. and Dickson, R. C. (1988) Cysteine residues in the zinc finger and
amino acids adjacent to the finger are necessary for DNA binding by the LAC9
regulatory protein of Kluyveromyces lactis. Mol. and Cell Biol. 8:3726-3733.
Bookjans, G., Altschuler, M., Brockman, J., Yenofsky, R., Polacco, J., Dickson, R.,
Collins, G. and Hildebrand, D. (1988) "Molecular Biological Studies of Plant
Lipoxygenases" in Proceedings World Conference on Biotechnology for the Fats
and Oils Industry, T. H. Applewhite, ed., American Oil Chemists' Society.
Dickson, R. C. and Riley, M. I. (1989) "Lactose regulation in Kluyveromyces lactis"
in Genetic Engineering of Yeast, P. J. Barr, A. J. Brake and P. Valenzula, eds.,
Butterworth, pp. 19-40.
Dickson, R. C., Wells, G. B., Schmidt, A. and Lester, R. L. (1990) Isolation of mutant
Saccharomyces cerevisiae strains that survive without sphingolipids. Mol. and Cell.
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Biol. 10:2176-2181.
Halvorsen, Y-D. C., Nandabalan, K., and Dickson, R. C. (1990) LAC9 DNA-binding
domain coordinates two zinc atoms per monomer and contacts DNA as a dimer, J.
Biol. Chem. 265:13283-13289.
Witte, M. M. and Dickson, R. C. (1990) The C6 zinc finger and adjacent amino acids
determine DNA-binding specificity and affinity in the yeast activator proteins LAC9
and PPR1, Mol. and Cell. Biol. 10:5128-5137.
Dickson, R. C., Gerardot, C. J., and Martin, A. K. (1990) Genetic evidence for
similar negative regulatory domains in the yeast transcription activators GAL4 and
LAC9. Nuc. Acids Res. 18:5213-5217.
Pan, T., Halvorsen Y.-D., Dickson, R. C., and Coleman J. E. (1990) The
transcription factor LAC9 from K. lactis like GAL4 from S. cerevisiae forms a
Zn(II)2Cys6 binuclear cluster. J. Biol. Chem. 265:21427-21429.
Halvorsen, Y.-D., Nandabalan, K., and Dickson, R. C. (1991) Identification of base
and backbone contacts used for DNA sequence recognition and high affinity binding
by LAC9, a transcription activator containing a C6 zinc finger, Mol. and Cell. Biol.
11:1777-1784.
Mylin, L. M., Gerardot, C. J., Hopper, J. E., and Dickson, R. C. (1991) Sequence
conservation in the Saccharomyces and Kluyveromyces GAL11 transcription
activators suggests functional domains. Nuc. Acids Res. 19:5345-5350.
Buede, R., Rinker-Schaffer, C., Pinto, W. J., Lester, R. L., and R. C. Dickson,
(1991) Cloning and characterization of LCB1, a Saccharomyces gene required for
biosynthesis of the long chair base component of sphingolipids. J. Bacteriol.
173:4325-4332.
Kuzhandhaivelu, N., Jones, W. K., Martin, A. K., and Dickson, R. C. (1992) The
signal for glucose repression of the lactose-galactose regulon is amplified through
subtle modulation of transcription of the Kluyveromyces lactis Kl-GAL4 activator
gene. Mol. Cell. Biol. 12:1924-1931.
Pinto, W. J., Srinivasan, B., Shepperd, S., Schmidt, A., Dickson, R. C., and Lester,
R. L. (1992) Sphingolipid long-chain base auxotrophs of Saccharomyces cerevisiae:
Genetics, Physiology, and a method for their selection. J. Bacteriol. 174:2565-2574.
Patton, J. L., Srinivasan, B., Dickson, R. C., and Lester, R. L. (1992) Phenotypes of
sphingolipid-dependent strains of Saccharomyces cerevisiae. J. Bacteriol.
174:7180-7184.
Lester, R. L. Wells, G. B., Oxford, G., Dickson, R. C. (1993) Mutant strains of
Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol
glycerophospholipids that mimic sphingolipid structures. J. Biol. Chem. 268:845856.
Lester, R. L. and R. C. Dickson. (1993) Sphingolipids with inositolphosphatecontaining head groups. Adv. Lipid Research. 26:253-274. (Invited review)
Nagiec, M. M., Wells, G. B., Lester, R. L. and R. C. Dickson. (1993) A suppressor
gene that enables Saccharomyces cerevisiae to grow without making sphingolipids
encodes a protein that resembles an Escherichia coli fatty acyltransferase. J. Biol.
Chem. 268:22156-22163.
Czyz, M., Nagiec, M. M. and Dickson, R. C. (1993) Autoregulation of GAL4
transcription is essential for rapid growth of Kluyveromyces lactis on lactose and
galactose. Nuc. Acids Res. 21:4378-4382.
Miller, C. S., Dickson, R. C., Anderson, P. E., and Jacob, R. J. (1994) Recent
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studies on ultraviolet light and hormonal stimulation of herpesvirus replication and
its potential in LATs gene expression: A Brief Review. SAAS Bulitin:Biochem. &
Biotech. 7:24-30.
Nagiec, M. M., Baltisberger, J. A., Wells, G. B., Lester R. L. and Dickson, R. C.
(1994) The LCB2 gene of Saccharomyces cerevisiae and the related LCB1 gene
encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid
synthesis. Proc. Natl. Acad. Sci. USA. 91:7899-7902.
Nagiec, M. M., Lester R. L. and Dickson, R. C. (1996) Sphingolipid synthesis:
identification and characterization of mammalian cDNAs encoding the Lcb2 subunit
of serine palmitoyltransferase. Gene. 177:237-241.
Wells, G. B., Dickson, R. C. and Lester, R. L. (1996) Isolation and composition of
inositolphosphorylceramide-type sphingolipids of hyphal forms of Candida albicans.
J. Bacterol. 178:6223-6226.
Skrzypek, M., Lester R. L. and Dickson, R. C. (1997) Suppressor gene analysis
reveals an essential role for sphingolipids in transport of
glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. J.
Bacterol. 179:1513-1520.
Nagiec, M. M., Nagiec, E. E., Baltisberger, J. A., Wells, G. B., Lester, R. L. and
Dickson, R. C. (1997) Sphingolipid synthesis as a target for antifungal drugs:
complementation of the inositol phosphorylceramide synthase defect in a mutant
strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272:98099817.
Qie, L., Nagiec, M. M., Baltisberger, J. A., Lester, R. L. and Dickson, R. C. (1997)
Identification of a Saccharomyces gene, LCB3, necessary for incorporation of
exogenous long chain bases into sphingolipids. J. Biol. Chem. 272:16110-16117.
Dickson, R. C., Nagiec, E. E., Wells, G. B., Nagiec, M. M. and Lester, R. L. (1997)
Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in
Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem.
272:29620-29625.
Dickson, R. C., Nagiec, E. E., Skrzypek, M., Tillman, P., Wells, G. B., and Lester, R.
L. (1997) Sphingolipids are potential heat stress signals in Saccharomyces. J. Biol.
Chem. 272:30196-30200.
Dong, J. and Dickson, R. C. (1997) Glucose represses the lactose-galactose
regulon in Kluyveromyces lactis through a SNF1 and MIG1-dependent pathway that
modulates galactokinase (GAL1) gene expression. Nuc. Acids Res. 25:3657-3664.
Hanada, K., Hara, T., Nishijima, M., Kuge, O., Dickson, R. C. and Najiec, M. M.
(1997) A mammalian homolog of the yeast LCB1 encodes a component of serine
palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis.
J. Biol. Chem. 272:32108-32114.
Skrzypek, M., Nagiec, M. M., Lester, R. C. and Dickson, R. C. (1998) Inhibition of
amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J.
Biol. Chem. 273:2829-2834.
Wells, G. B., Dickson, R. C. and Lester, R. L. (1998) Heat-induced elevation of
ceramide in Saccharomyces cerevisiae via de novo synthesis. J. Biol. Chem.
273:7235-7243.
Grilley, M. M., Stock, S. D., Dickson, R. C., Lester, R. L. and Takemoto, J. Y.
(1998) Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation
in Saccharomyces cerevisiae. J. Biol. Chem. 273:11062-11068.
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Dickson, R. C. (1998) Sphingolipid functions in Saccharomyces cerevisiae:
comparison to mammals. Annu. Rev. Biochemistry. 67:27-48. (Invited review)
Nagiec, M., Skrzypek, M., Nagiec, E. N., Lester, R. L. and Dickson R. C. (1998) The
LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode
sphingolipid long chain base kinases. J. Biol. Chem. 273:19437-19442.
Kohama, T., Olivera, A., Edsall, L., Nagiec, M. M., Dickson, R. and Spiegel, S.
(1998) Molecular cloning and functional characterization of murine sphingosine
kinase. J. Biol. Chem. 273:23722-23728.
Farrell, A. M., Uchida, Y., Nagiec, M. M., Harris, I. R., Dickson, R. C., Elias, P. M.,
Halloran, W. M. (1998) UVB irradiation up-regulates serine palmitoyltransferase in
cultured human keratinocytes. J. Lipid Res. 39:2031-2038.
Daum, G., Lees, N. D., Bard, M. and Dickson, R. (1998) Biochemistry, Cell Biology
and Molecular Biology of Lipids of Saccharomyces cerevisiae. Yeast 14:1471-1510.
(Invited review)
Dickson, R. C. and Lester, R. L. (1999) Yeast Sphingolipids. Biochem. Biophysics
Acta 1426:347-357. (Invited review)
Skrzypek, M., Nagiec, M. M., Lester, R. L. and Dickson, R. C. (1999) Analysis of
phosphorylated sphingolipids long-chain bases reveals potential roles in heat stress
and growth control in Saccharomyces. J. Bacteriol. 181:1134-1140.
Osuka, S., Takeda, J., Nagiec, M. M., Dickson, R. C. and Y. Hirabayashi. (1999)
Assignment of Sptlc2 to murine chromosome band 12, region E by in situ
hybridization. Cytogenetics and Cell Genetics 82:222-223.
Dickson, R. C. and Lester, R. L. (1999) Metabolism and selected functions of
sphingolipids in the yeast Saccharomyces cerevisiae. Biochem. Biophysics Acta
1438:305-321. (Invited review)
Dickson, R. C., Lester, R. L. and Nagiec, M. M. (1999) Serine Palmitoyltransferase.
Methods in Enzymology 311:3-9.
Thevissen, K., Lemaire, K., Winderickx, J., Dickson, R. C., Lester, R. L., Parret, A.
H. A., Cammue, B. B. P. A. and Broekaert, W. F. (2000) A gene encoding a
sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces
cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc. Natl.
Acad. Sci. USA, 97:9531-9536.
Skrzypek, M., Lester, R. L., Spielmann, P., Zingg, N., Shelling, J. and Dickson, R. C.
(2000) Dominant suppressor mutation bypasses the sphingolipid requirement for
growth of Saccharomyces cells at low pH: role of the CWP2 gene. Current Genetics,
38:191-201.
Birchwood, C. J., Saba, J. D., Dickson, R. C. and Cunningham, K. W. (2001)
Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1phosphate accumulation. J. Biol. Chem. 276:11712-11718.
Feoktistova, A., Magnelli, P., Abeijon, C., Perez, P., Lester, R. L., Dickson, R. C.
and Gould, K. L. (2001) Coordination between fission yeast glucan formation and
growth requires a sphingolipase activity. Genetics, 158:1397-1411.
Lester, R. L. and Dickson, R. C. (2001) Analysis of molecular species of
sphingolipid-related long chain bases and long chain base phosphates in
Saccharomyces cerevisiae. Anal. Biochem. 298:283-292.
Zhang, X., Skrzypek, M., Lester, R. L. and Dickson, R. C. (2001) Elevation of
endogenous sphingolipid long chain bases phosphates kills Saccharomyces
cerevisiae cells. Current Genet. 40:221-233.
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Ferguson-Yankey, S. R., Skrzypek, M., Lester, R. L. and Dickson, R. C. (2002)
Mutant analysis reveals complex regulation of sphingolipid long chain base
phosphates and long chain base levels during heat stress. Yeast, 18:573-586.
Dickson, R. C. and Lester, R. L. (2002) Sphingolipid functions in Saccharomyces
cerevisiae. Biochem. Biophysics Acta. 1583:13-25.
Hait, N. C., Fujita, K., Lester, R. L. and Dickson, R. C. (2002) Lcb4p sphingoid base
kinase localizes to the Golgi and late endosomes. FEBS Letters, 532:97-102.
Hearn, J. D., Lester, R. L. and Dickson, R. C. (2003) The uracil transporter Fur4p
associates with lipid rafts. J. Biol. Chem. 278:3679-3686.
Chung, J-H., Lester, R. L. and Dickson, R. C. (2003) Sphingolipid requirement for
functional association of the Vacuolar ATPase domains V 1 and V0. J. Biol. Chem.
278:28872-28881.
Zhang, X., Lester, R. L. and Dickson, R. C. (2004) Pil1p and Lsp1p negatively
regulate the PKD1-like kinase Pkh1p and downstream signaling pathways Pkc1p
and Ypk1p. J. Biol. Chem. 279:22030-22038.
Liu, K., Zhang, X., Lester, R. L. and Dickson R. C. (2005) The sphingolipid long
chain bases phytosphingosine activates AGC kinases in Saccharomyces cerevisiae
including Ypk1, Ypk2 and Sch9. J. Biol. Chem. 280:22679-22687.
Zink, S., Mehlgarten, C., Kitamoto, H. K., Nagase, J., Jablonowski, D., Dickson, R.
C., Star,k M. J. R. and Schaffrath, R. (2005) Mannosyl-diinositolphospho-ceramide,
the major yeast plasma membrane sphingolipid, governs toxicity of the
Kluyveromyces lactis zymocin. Eukaryotic Cell. 4:879-889.
Liu, K., Zhang, X., Sumanasekera, C., Lester, R. L. and Dickson, R. C. (2005)
Signaling Function for Sphingolipid Long Chain Bases in Saccharomyces cerevisiae.
Biochem. Soc. Trans. 33:1170-1173.
Valachovic, M., Bareither, B. M., Bhuiyan, M. S. A., Eckstein, J., Barbuch, R.,
Balderes, D., Wilcox, L., Sturley, S. L., Dickson, R. C., and Bard, M. (2006)
Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces
cerevisiae result in synthetic lethality that is suppressed by alterations in
sphingolipid profiles. Genetics, 173:1893-1908.
Dickson, R. C., Sumanasekera, C. and Lester, R. L. (2006) Function and
Metabolism of Sphingolipids in Saccharomyces cerevisiae. Progress in Lipid
Research, 45:447-465.
Dickson, R. C. and Lester, R. L. (2006) Current Perspectives on Saccharomyces
cerevisiae Sphingolipids. In “Biology of Sphingolipids,” eds. Hirabayashi, Y.,
Igarashi, Y., and Merrill, A. Jr. Springer, Toyko, pp. 141-150.
Linn, S. C., Andras, L. M., Kin, H-S., Wei, J., Nagiec, M. M., Dickson, R. C. and
Merrill, A. H. Jr. (2006) Functional Characterization of the Promoter for the Mouse
SPTLC2 Gene, which Encodes Subunit 2 of Serine Palmitoyltransferase. FEBS
Letters, 580:6217-6223.
Brace, J., L., Lester, R. L., Dickson, R. C. and Rudin, C. M. (2007) SVF1 Regulates
Cell Survival by Affecting Sphingolipids Metabolism in Saccharomyces cerevisiae.
Genetics, 175:65-76.
Dickson, R. C. (2008) More Chores for TOR: de novo Ceramide Synthesis. Cell
Metabolism, 7:99-100.
Luo, G., Gruhler, A., Liu, Y., Jensen, O. N., Dickson, R. C. (2008) The Sphingolipid
Long-chain Base-Pkh1/2-Ypk1/2 Signaling Pathway Regulates Eisosome Assembly
and Turnover. JBC, 283:10433-10444.
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Dickson, R. C. (2008) New Insights into Sphingolipid Metabolism and Function. J.
Lipid Res. 49:909-921.
Dickson, R. C. (2010) Roles for Sphingolipids in Saccharomyces cerevisiae. Adv.
Exp. Med. Biol., 688:217-231.
Luo, G. Costanzo, M. Boone, C., Dickson, R. C. (2011). Nutrients and the Pkh1/2
and Pkc1 Protein Kinases Control mRNA Decay and P-body Assembly in Yeast.
JBC 286:8759-70. PMID:21163942, PMCID:PMC3059008.
Huang, X., Liu, J., Dickson, R. C. (2012) Down-regulating sphingolipid synthesis
increases yeast lifespan, PLoS Genet. 8(2): e1002493. PMID:22319457, PMCID:
PMCID3271065.
Lee, Y-J., Huang, X., Kropat, J., Henras, A., Merchant, S. S., Dickson, R. C.,
Chanfreau, G. F. (2012) Sphingolipid Signaling Mediates Iron Toxicity, Cell
Metabolism 16:90-96. PMID:22768841, PMCID:PMC3653578.
Lester, R.L., Withers, B.R., Schultz, M.A., Dickson, R.C. (2013) Iron, glucose and
intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.
Biochim Biophys Acta – Molecular and Cell Biology of Lipids. 1831:726-736.
PMID:23286903, PMCID:PMC3594326.
Huang, X., Liu, J., Withers, B. R., Samide, A. J., Leggas, M., Dickson, R. C. (2013)
Reducing Signs of Aging and Increasing Lifespan by Drug Synergy. Aging Cell
12:652-660. PMID:23601176, PMCID:PMC3714353.
Liu, J., Huang, X., Withers, B. R., Blalock, E., Liu, K., Dickson, R. C. (2013)
Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast
Lifespan. Aging Cell, 12:833-841. PMID:23725375, PMCID:PMC3773046.
Huang, X., Withers, B. R., Dickson, R. C. (2014) Sphingolipids and Lifespan
Regulation. Biochim Biophys Acta. 1851: 657-664.
DOI:10.1016/j.bbalip.2013.08.006. PMID:23954556.
Books and book chapters:
1. Dickson, R. C. and M. Mendenhall (2004) Editors of the 2nd edition of “Signal
Transduction Protocols.” Humana Press.
2. Dickson, R. C. (2009) Roles for Sphingolipids in Saccharomyces cerevisiae. Chapter
20, in Sphingolipids as Signaling and Regulatory Molecules. Landes Biosciences
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