ERIE COMMUNITY COLLEGE
NORTH CAMPUS
COURSE OUTLINE
A.
Unit Code:
Suggested Course Title:
2188
ML 112-Clinical Analysis I
B.
Curriculum/Program:
Clinical Laboratory Technician
C.
Catalog Description:
This course introduces the student to clinical chemistry. It covers the discussion of
laboratory chemicals, methods of water purification, laboratory concentration units and
calculations, collection and handling of blood specimens, variation in laboratory results,
quality control and reference intervals.
Prerequisites: High school chemistry and Algebra (or equivalent) Pretest M20;
Co-requisites: CH 146, or CH 180, MT 125 or MT 143 or permission of instructor.
F (N)
D.
Duration of
Instructional Period:
100 minutes per week, 1/2 class meeting per week,
15 weeks
E.
Academic Credit Hours:
Contact Hours:
2.0
2.0
(2-0-2)
F.
Suggested Text/
Course Materials:
Clinical Chemistry, by Bishop, Fody,
and Schoeff
G.
Course Outcomes:
Upon completion of this course, the student will be able to:
1.
2.
3.
4.
5.
6.
4/14
Identify which of the various grades of chemicals is suitable for use in clinical
analysis and state common storage and safety precautions for laboratory
chemicals.
Identify the kinds of water to be used in clinical analysis and describe methods
of water purification.
Calculate both concentrations and content of solutions in the concentration units
employed in clinical analysis.
Perform dilution calculations when given appropriate information.
Calculate the volumes of various stock solutions required to make working
standards for a colorimetric analysis and to make solutions of acids and bases.
State whether an anticoagulant is needed in collection of a blood specimen, and
if so, which anticoagulant is preferable for the particular determination.
1
7.
8.
9.
10.
11.
12.
13.
H.
State the precautions required in collection and handling of specimens for
particular determinations.
Name and describe the factors that can cause variations in laboratory results.
Calculate the standard deviation, mean, median, mode, and coefficient of
variation.
Define the terms accuracy, precision, and reliability as they relate to clinical
measurements.
State the essential characteristics of controls and explain their use in the clinical
laboratory.
Describe the setting-up and interpretation of Quality Control Charts.
Discuss the development of reference (normal) ranges.
Program Competencies:
Upon graduation with an Associate in Applied Science Degree in Clinical Laboratory
Technician, the graduate will be able to:
1.
2.
3.
4.
5.
6.
I.
Collect and prepare human samples for analysis. Store and transport samples
using appropriate preservation methods. Specimens may include blood, urine
and other body fluids. (6,7)
Calculate the results of tests performed if necessary. (3)
Prepare reagents and media according to prescribed procedures. (1-5)
Perform, record and evaluate all quality control procedures required for the tests
assayed. (8-12)
Recognize abnormal or unusual test results and follow institutional procedures
for reporting critical values. (13)
Observe established safety measures. (1,7)
SUNY General Education Knowledge and Skills Areas:
Not applicable to course offering in Health Science Division.
J.
ECC Learning Outcomes (LO):
1.
2.
3.
K.
Information Literacy (1-13)
Scientific Reasoning (1-13)
Quantitative Reasoning (3, 4, 5, & 9)
Assessment of Student Learning:
K1. Evaluation of Student Learning: Course outcomes may be met by hourly
examination, quizzes, selected homework assignments, oral presentations, case
evaluations, attendance, and a written project. The final grade will be calculated as follows:
 Hourly Exams
30%
 Comprehensive Final Exam
30%
 Homework
10%
4/14
2



Quizzes
Attendance
Project
10%
10%
10%
K2. Assessment of Student Learning: The methods of evaluation should be consistent
with the level of the course and meet criteria as set forth by the Accreditation Agencies to
include cognitive levels I, II, and III, as well as, affective and psychomotor skills
appropriate to the course.
L.
Library Resources:
Medical Laboratory Technology/Clinical Laboratory Technology reference books and
journals particularly those pertaining to Clinical Chemistry.
M.
Topical Outline:
Instructional Units
4/14
Instructional Periods
1.
Laboratory Chemicals
a.
Primary and secondary standards
b
ACS grade, AR grade
c.
Ultra Pure grade
d.
Chemically Pure grade
e.
USP and NF grades
f.
Technical grade
g.
Storage and safety precautions
1 week
2.
Methods of Water Purification
a.
Distillation
b.
Deionization
1 week
3.
Laboratory Concentration Units and Calculations
a.
percent (w/v, v/v, w/w)
b.
mg/dl
c.
molarity
d.
mmol/L
e.
normality
f.
mEq/L
g.
dilutions
4 weeks
4.
Collection and Handling of Blood Specimens for Clinical Analysis
a.
Time of specimen collection.
b.
Serum specimen collection and handling.
c.
Anticoagulants.
d.
Plasma specimen collection and handling.
e.
Whole blood collection and handling.
3 weeks
3
f.
g.
h.
N.
4/14
Special precautions associated with specific lab determinations.
Drug interference.
Hemolysis.
5.
Sources of Variation in Laboratory Results
a.
Inter-individual variation.
b.
Intra-individual variation.
c.
Preanalytical Factors.
d.
Analytical Factors.
e.
Systematic versus Random Variation.
f.
Post-analytical Factors.
1 week
6.
Basic Statistics
a.
The Gaussian Frequency Curve.
b.
Standard deviation.
c.
Mean, median, mode.
d.
Co-efficient of variation.
1 week
7.
Quality Control
a.
Accuracy.
b.
Precision.
c.
Reliability.
d.
Control specimens.
e.
Quality Control Charts.
f.
Westgard Rules.
g.
Proficiency Testing.
h.
Development of reference (normal) ranges
4 weeks
Proposal Prepared by:
Date Prepared:
Date Last Updated:
CLT/MA Faculty
April 2014
April 2008
4