INTERNATIONAL COUNCIL FOR LABORATORY ANIMAL SCIENCE
ICLAS ANIMAL QUALITY NETWORK
PEP SPECIMEN PRODUCTION
PEP Specimen Producer Laboratories

Central Institute for Experimental Animals, (CIEA), Kawasaki, Japan

Charles River, Research Animal Diagnostic Services, Wilmington, USA

IDEXX RADIL, Missouri, USA

Microbiological Diagnostics, German Cancer Research Centre, Heidelberg, Germany

QM Diagnostics, Nijmegen, the Netherlands
Production and Characterization of PEP Specimens

All specimens are generated under strict conditions and rigorously characterized.

Infectious agents are obtained from known sources and sequenced to confirm identity.

Experimental animals are then inoculated and the serum and relevant tissues are collected
and aliquoted for use as standardized specimens.

Aliquoted specimens are evaluated by two laboratories to confirm quality
PEP Specimen Quality Control

Acceptance Criteria: Pure and Potent

Immune Serum
–Seropositive to inoculated pathogen only
–Moderate to strong reaction by standard assays

Infectious Specimen
–Free of extraneous pathogens
–Easily detected concentration of pathogen