Keith R. Yamamoto, Ph.D.
CURRICULUM VITAE
Name:
Keith Robert Yamamoto
Date of Birth:
February 4, 1946
Place of Birth:
Des Moines, Iowa
Education:
B.Sc. 1968 Biochemistry and Biophysics
Iowa State University
Ph.D. 1973 Biochemical Sciences
Princeton University
Research and Professional Activities:
1973-1975
Postdoctoral Fellow
Department of Biochemistry and Biophysics
University of California, San Francisco (UCSF)
1976-1979
Assistant Professor of Biochemistry
Department of Biochemistry and Biophysics, UCSF
1979-1983
Associate Professor of Biochemistry
Department of Biochemistry and Biophysics, UCSF
1983-2003
Professor of Biochemistry
Department of Biochemistry and Biophysics, UCSF
1985-1994
Vice Chairman
Department of Biochemistry and Biophysics, UCSF
1988-2001
Director
Biochemistry and Molecular Biology Program
Program in Biological Sciences, UCSF
1994–
Professor
Department of Cellular and Molecular Pharmacology, UCSF
1994-2003
Chairman
Department of Cellular and Molecular Pharmacology, UCSF
2002-2003
Vice Dean for Research
School of Medicine, UCSF
2004–
Executive Vice Dean
School of Medicine, UCSF
2011–
Vice Chancellor for Research, UCSF
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Honors:
Iowa State University Special Merit Scholarship (1964-1968)
NSF Undergraduate Research Grant (1967-1968)
Helen Hay Whitney Postdoctoral Fellowship (1973-1976)
NIH Research Career Development Award (1977-1982)
UCSF Distinguished Teaching Award (1979-1980)
Dreyfus Teacher-Scholar Award (1982-1986)
Elected Fellow, American Academy of Arts and Sciences (1988)
NIH MERIT Award (1989-1998)
Elected Member, National Academy of Sciences (1989)
Gregory Pincus Medal (1990)
Elected Fellow, American Academy of Microbiology (1992)
Iowa State University Distinguished Achievement Award (1997)
Theodore Roosevelt High School Hall of Fame, Des Moines (1998)
Vanderbilt Medal of Merit, Vanderbilt University (1999)
Iowa State University D.Sc., honorary (2001)
Holly Smith Award for Exceptional Service to the School of Medicine, UCSF (2001)
Elected Fellow, American Association for the Advancement of Science (2002)
Elected Member, Institute of Medicine of the National Academy of Sciences (2003)
Allan Munck Prize, Dartmouth University (2004)
10 Influential People to Watch in Biomedical Policy, Nature Medicine (2008)
UCSF Postdoctoral Scholars Association Outstanding Faculty Mentorship Award (2010)
The Endocrine Society Edwin B. Astwood Award (2012)
The American Society for Cell Biology Public Service Award (2012)
Iowa State University John V. Atanasoff Discovery Award (2013)
Honorary Lectureships:
Swerling Lecturer, Harvard Medical School (1982)
Rudin Lecturer, Columbia University, College of Physicians and Surgeons (1983)
Weissberger Lecturer, University of Rochester (1983)
Keynote Speaker, Lost Pines Molecular Biology Conference, University of Texas System
Cancer Center (1986)
Keynote Speaker, New Insights into the Regulation of Transcription, Stony Brook
Symposium (1987)
Axelrod Lecturer, Purdue University (1988)
Plenary Lecturer, Cold Spring Harbor Symposium (1988)
Markey Lecturer, Harvard Medical School (1990)
Lindner Lecturer, Weizmann Institute (1990)
Keynote Speaker, West Central States Biochemistry Conference (1991)
Steenbock Lecturer, University of Wisconsin (1992)
Keynote Speaker, Transcription: Factors, Regulation and Differentiation, Keystone
Symposium (1993)
Matrone Lecturer, North Carolina State University (1993)
Keynote Speaker, Steroid Receptor Superfamily Symposium, University of Wisconsin,
Madison (1994)
Keynote Speaker, Whitehead Institute Symposium XII, Transcriptional Control (1994)
Sadler Lecturer, University of Colorado Health Sciences Center (1995)
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duVigneaud Lecturer, Cornell University (1995)
Kosuge Lecturer, University of California, Davis (1995)
Keynote Speaker, 15th International Conference on Plant Growth Substances,
Minneapolis, Minnesota (1995)
Harvey Lecturer, Rockefeller University (1995)
Monsanto Lecturer, Ohio State University (1996)
Ochoa Lecturer, New York University (1996)
Keynote Speaker, Regulation of Transcription, Translation, and Posttranslational
Modifications, Howard Hughes Medical Institute Scientific Meeting (1996)
Faculty Research Lecturer, UCSF (1997)
Commencement Speaker, UC Berkeley Molecular and Cell Biology, Undergraduate
(1997)
Taurog Lecturer, University of Texas Southwestern Medical Center (1998)
Flexner Lecturer, Vanderbilt University (1999)
Wells Lecturer, Michigan State University (2001)
The Chao Hao Li Memorial Lecturer, Institute of Biological Chemistry, Academia Sinica
and National Taiwan University, Teipei (2004)
Allan Munck Prize Lecturer, Dartmouth University (2004)
Commencement Speaker, Watson School Biological Sciences, Cold Spring Harbor Lab
(2004)
Ray A. and Robert L. Kroc Lecture, Joslin Diabetes Center, Harvard Medical School (2007)
Keynote Speaker, Opening Convocation, Van Andel Institute (2007)
Louis Sanford Goodman Lecture, Oregon Health and Sciences University (2007)
Christian Herter Lecture, New York University (2008)
8th Annual Doris Howes Calloway Memorial Lecture, Department of Nutritional Science &
Toxicology, UC Berkeley (2009)
Keynote Speaker, RNA & Society Dinner, RNA 2009 (14th Annual Meeting of the RNA
Society), University of Madison, Wisconsin (2009)
Invited Guest Lecturer, Serbian Academy of Sciences and Arts, Belgrade, Serbia (2009)
Keynote Speaker, University of California Davis Molecular and Cellular Biology NIH
Training Grant Retreat, Fallen Leaf Lake, CA (2009)
Keynote Speaker, NIH Graduate Research Symposium, Natcher Conference Center, NIH
Campus (2009)
34th Annual Carl F. Schmidt Honorary Lecture, The University of Pennsylvania School of
Medicine, Department of Pharmacology (2010)
Keynote Speaker, Jefferson College of Graduate Studies Fifth Annual Postdoctoral
Research Symposium (2010)
Commencement Speaker, Biological Sciences, University of Chicago (2010)
9th Annual Fred Sherman Lecture, University of Rochester (2011)
Keynote Speaker, UCSF Breast Oncology Program Scientific Retreat (2012)
40th Annual Distinguished Schueler Lectureship, Tulane University (2012)
Martin Rodbell Memorial Lecture, NIH NIEHS (2012)
Arnold D. Welch Lecturer in Pharmacology, Danny Thomas Lecture Series, St. Jude
Children’s Research Hospital (2012)
Commencement Speaker, Department of Molecular & Cell Biology (Graduate), UC
Berkeley (2012)
Edwin B. Astwood Lecturer, Endocrine Society (2012)
Keynote Lecturer, US HUPO, The Future of Proteomics (2012)
IMED Lecturer, UCLA (2012)
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Editorial Boards:
Biochemistry (1980-1982)
Journal of Biological Chemistry (1980-1985)
Biological Regulation and Development (Plenum Press) (1980-1985)
Cell Regulation, Associate Editor(1988-1991)
Journal of Molecular Biology, Associate Editor (1988-2001)
Current Biology Journal Group (1989-1998)
Journal of NIH Research (1989-1997)
Genes and Development (1990-1992)
Science, Board of Reviewing Editors (1990-1994)
Mechanisms of Development (1990-1995)
Protein Science (1990-1993)
Molecular Biology of the Cell, Editor (1991-2001), Editor-in-Chief (2001-2003)
UCSF Magazine (1992–1999)
Advances in Second Messenger and Phosphoprotein Research (Raven Press) (1993–1997)
Chemistry & Biology (1994-2003)
Annual Review of Biochemistry (1996-2000)
Proceedings of the National Academy of Sciences (2001)
Encyclopedia of Transcription (Academic Press) Advisory Board (2001–2005)
Societies:
American Society for Microbiology
American Society for Biochemistry and Molecular Biology
Publications Committee (1990-1993)
Chairman, Nominations Committee (1994-1997)
Public Affairs Advisory Committee (1997-2010)
American Society for Developmental Biology
American Society for Cell Biology
Program Committee (1989; 1992-1993; 1997)
Nominations Committee (1990)
Council (1991-1994)
Public Policy Committee (1992-2001)
The Endocrine Society
Genetics Society of America
American Association for the Advancement of Science
Committee on Nominations (1994-1996) (2012-)
American Society for Pharmacology and Experimental Therapeutics
Conferences Chaired, Organized:
Co-Chairman, Gordon Conference on Biological Regulatory Mechanisms (1979)
Co-Chairman, Conference on “Regulation of mRNA Transcription,” Cold Spring Harbor
Lab (1989)
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Organizer, NIH Workshop “New Approaches to Understanding Cell Cycle Regulation”
(1989)
Co-Chairman, Conference on “Regulation of Eukaryotic mRNA Transcription,” Cold
Spring Harbor lab (1991)
Co-Chairman, Gordon Conference on Animal Cells and Viruses (1992)
Co-Chairman, Conference on “Regulation of Eukaryotic Transcription,” Cold Spring
Harbor Lab (1993)
Co-Chairman, UCSF Symposium "Wondrous Voyages: Science and Health for a New
Century" (1994)
Co-Organizer, "Reviewing Peer Review: An Assessment of NIH Study Sections” (1994)
Co-Chairman, Conference on “Cancer Cells: Mechanisms of Eukaryotic Transcription,”
Cold Spring Harbor Lab (1995)
Co-Organizer, Jane Coffin Childs Memorial Fund for Medical Research Symposium on
"Intersection of Transcription, Cancer and Growth Regulation" (1995)
Co-Organizer, Banbury Conference on "Mechanisms of Transcriptional Initiation," Cold
Spring Harbor Lab (1996)
Co-Organizer, Conference on "Mechanisms of Eukaryotic Transcription," Cold Spring
Harbor Lab (1997)
Co-Organizer, Jane Coffin Childs Memorial Fund for Medical Research Symposium on
"Cellular Machines" (1999)
Co-Organizer, Banbury Center Workshop on "Nuclear Receptors," Cold Spring Harbor
Lab(2002)
Co-Organizer, "Nuclear Receptors: Bench to Bedside, " Cold Spring Harbor Lab (2006)
Co-Organizer, "Nuclear Receptors: Bench to Bedside, " Cold Spring Harbor Lab (2008)
Co-Organizer, "Nuclear Receptors from Molecular Mechanism to Molecular Medicine,"
EMBO Conference, Croatia (2009)
Co-Organizer, "Nuclear Receptors & Disease," Cold Spring Harbor Lab (2010)
Co-Organizer, “Nuclear Receptors & Disease,” Cold Spring Harbor Lab (2012)
Institute/Department Review Committees:
External Review Committee, University of Toronto, Banting and Best Institute (1985)
External Review Committee, Northwestern University, Department of Biochemistry,
Molecular Biology, and Cell Biology (1987)
Chairman, External Review Committee, Indiana University, Department of Biology
(1992)
External Review Committee, Rutgers University, Department of Molecular Biology and
Biochemistry; Waksman Institute of Microbiology; Joint Graduate Program in
Biochemistry (1993)
External Review Committee, Northwestern University, Departments of Microbiology
and Immunology; Cell, Molecular and Structural Biology; Biochemistry,
Molecular Biology and Cell Biology (1994)
External Review Committee, Univ of Massachusetts Medical Center, Department of
Biochemistry and Molecular Biology (1994)
Chairman, External/Internal Review Committee, UCSF, Cardiovascular Research
Institute (1994)
External Review Committee, University of California, Santa Cruz, Department of
Biology (1995)
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External Review Committee, University of California, Los Angeles, ACCESS Graduate
Programs in the Molecular and Life Sciences (1996)
Chairman, External Review Committee, Cold Spring Harbor Lab, proposed Graduate
Program in Biological Sciences (1998-99)
Chairman, External Review Committee, Watson School of Biological Sciences, Cold
Spring Harbor Lab (2000- )
External Review Committee, University of Southern California School of Medicine,
Basic Sciences (2002)
External Review Committee, University of Utah, Department of Oncological Sciences
(2002)
Chairman, External Review Committee, Harvard Medical School, Department of
Biological Chemistry and Molecular Pharmacology (2004)
Chairman, External Review Committee, Columbia University Medical Center,
Department of Pharmacology (2005)
External Review Committee, Duke University Medical Center, Department of
Pharmacology and Cancer Biology (2005)
External Review Committee, Northwestern University, Searle Leadership Fund (2005)
External Review Committee, Iowa State University, Department of Genetics (2007)
External Review Committee, Iowa State University, Department of Biochemistry,
Biophysics, and Molecular Biology (2008)
Government, Public and Non-profit Advisory Boards:
°NIH
NIH Molecular Biology Study Section (1986-1990, 1996); Chairman (1987-1990)
NIH Director's Subcommittee on Intramural Research
Program Review Procedures (1989)
NIH National Advisory Council for Human Genome Research (1990-1992)
NIH Strategic Plan National Task Force (1992)
National Advisory Council, National Institute for General Medical Sciences, NIH (1993,
1994)
NIH Director's Working Group on the Division of Research Grants (1994-1995)
NIH Reinvention Roundtable on Peer Review (1994)
NIH Center for Scientific Review (formerly DRG) Advisory Committee (1995-1996);
Chairman (1996-2000)
NIH Director's Peer Review Oversight Group, (1996-1999)
NIH Advisory Committee to the Director, ad hoc member (1996-1997)
NIH National Advisory Council and Board Representatives (1996-2000)
NIH National Cancer Institute Prostate Cancer Progress Review Group (1997-1998)
NIH Center for Scientific Review, Panel on Scientific Boundaries for Review (1998-2000)
NIH CSR Special Review Panel: Bioengineering Research Partnerships (2000)
NIH Study Section Boundaries Team: Digestive Sciences IRG (2002)
NIH Center for Scientific Review, Roadmap Focus Group (2002)
NIH Study Section Boundaries Team: Molecular Approaches to Cell Function and
Interactions IRG (2003)
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NIH Director's Pioneer Award reviewer (2006, 2007)
NIH National Center for Research Resources, Director Search Committee (2006)
NIH Advisory Committee to the Director (2007-2010)
NIH ACD Working Group on Enhancing Peer Review, Co-Chair (2007-2008)
NIH CSR Intercellular Interactions Study Section, ad hoc reviewer (2007)
NIH Office of Portfolio Analysis and Strategic Initiatives: Innovation Workshop, CoOrganizer (2007)
NIH Transformational R01 Study Section, Co-Chair (2009)
NIH NCI National Cancer Advisory Board ad hoc Working Group: Creating a Strategic
Scientific Vision for the National Cancer Program and Review of the National
Cancer Institute (2010)
NIH Center for Scientific Review Advisory Council (2011-)
NIH Advisory Committee to the Director Biomedical Workforce (2011-)
NIH Advisory Committee to the Director Working Group on Diversity in the Biomedical
Workforce (2011-)
°Other Federal Agencies
NSF Genetic Biology Review Panel (1984-1987)
NSF Division of Molecular and Cellular Biosciences, Committee of Visitors (1995)
NSF National Science Board Task Force on Transformative Research, ad hoc member (20052006)
°National Academy of Sciences/National Research Council
National Academy of Sciences Panel on Scientific Responsibility and the Conduct of
Research (1990-1991)
National Academy of Sciences, International Science Foundation Biology Review Panel
(1993)
National Academy of Sciences, Committee on Publications (2003-2008)
National Academy of Sciences, Board on Life Sciences (2003-2006); Chairman (2006-2012)
National Research Council Committee "Bridges to Independence: Identifying
Opportunities for and Fostering the Independence of Young Investigators in the Life
Sciences" (2004-2005)
National Research Council Committee "A New Biology for the 21st Century: Ensuring the
United States Leads the Coming Biology Revolution" (2009)
National Research Council Committee "Toward Precision Medicine: Building a Knowledge
Network for Biomedical Research and a New Taxonomy of Disease" (2011)
Institute of Medicine Council (IOM) (2012 - )
National Academy of Sciences, Division on Earth and Life Sciences (DELS) Advisory
Committee (2012 - )
°Other Private (Not for Profit) Agencies
Foundation for Research in Hereditary Disease (1974)
Damon Runyon-Walter Winchell Cancer Fund, Scientific Advisory Committee (19771981)
UC Biotechnology Research and Education Program
Executive Committee (1986-1988)
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Fox Chase Cancer Center Scientific Advisory Committee (1990-1994)
American Academy of Microbiology Colloquium on Ethics in Science Steering
Committee (1992-1994)
The Jane Coffin Childs Memorial Fund for Medical Research, Board of Scientific
Advisors (1992-1999)
Forum on Science in the National Interest, White House Office of Science and
Technology Policy (1993)
FASEB Consensus Conference on Federal Research Funding for the Biomedical and Life
Sciences FY 96, NIH Subcommittee (1994), FY 99 (1997)
Joint Steering Committee for Public Policy (1996–2009) [Renamed in 2007: Coalition for the
Life Sciences]; Chairman (2009- )
Vollum Institute, Oregon Health Sciences University, Scientific Advisory Board (1997–2001)
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, External Advisory
Committee (1998–)
Dean and Betty Gallo Prostate Cancer Institute, External Advisory Board (1999–2005)
Northern California Institute for Research and Education, Inc., Board of Directors (2002–)
Lasker Foundation Forum on Ethical Challenges in Biomedical Research and Practice (2003)
American Academy of Arts and Sciences, Committee on Alternative Mechanisms for
Federal Funding of Research (2007-2008)
American Society for Biochemistry and Molecular Biology, Public Affairs Advisory
Committee (2007-2010)
American Society for Biochemistry and Molecular Biology, President's Advisory Committee
(2007)
UCSF NIH HIV Accessory and Regulatory Complexes Center, Scientific Advisory Board
(2007-)
Bill and Melinda Gates Foundation Grand Challenges Explorations Review Panel (20082009)
American Academy of Arts and Sciences, Chair of ARISE II Study: The Role of Academia,
Industry, and Government in the 21st Century (2009-)
Lawrence Berkeley National Laboratory (LBNL) Advisory Board (2011-)
Research!America Board of Directors (2012-)
National Centers for Biomedical Computing (NCBC) Scientific Advisory Board (2012-)
American Association for the Advancement of Science (AAAS), Committee on Nominations
(2012 - )
Research!America Membership Committee (2013-)
Corporate Advisory Boards:
Tularik Inc. Scientific Advisory Board (1992-2004)
Morphogenesis, Inc. Scientific Advisory Board (1994)
Burrill & Company Scientific Advisory Board (1997–)
CIStem Corporation Scientific Board (2000–2001)
Zorphion Therapeutics, Scientific Advisory Board (2003 – 2006)
BiPar Sciences, Inc. Scientific Advisory Board (2004–2009)
Amgen, Inc. Scientific Advisory Board (2005–2006)
Sirna Therapeutics, Inc. Scientific Advisory Board, Chair (2005 – 2007)
Merck & Co., Inc. Research Strategy Review Committee (2007 – 2010)
Sangamo Biosciences, Inc., Scientific Advisory Board (2007 – 2012)
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Extramural Courses:
Faculty, NATO course on Cellular and Molecular Aspects of Developmental Biology,
Les Houches, France (1984)
Faculty, MBL Embryology Course, Woods Hole, Massachusetts (1988)
Lecturer, Cold Spring Harbor Courses:
Advanced Molecular Cloning (1983, 1987, 1990, 1991, 1992, 1993)
Neurobiology (1984)
Yeast Molecular Biology (1988)
Eukaryotic Gene Expression (1996, 2002, 2003, 2007, 2011)
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SCIENTIFIC PUBLICATIONS
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Johnson, J.L., Yamamoto, K.R., Weislogel, P.O., and Horowitz, J. (1969) Some
properties of transfer ribonucleic acids from 5-fluorouracil-treated Escherichia coli.
Biochem. 8, 1901-1908.
Yamamoto, K.R., Alberts, B.M., Benzinger, R., Lawhorne, L., and Treiber, G. (1970)
Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its
application to large scale virus purification. Virology 40, 734-744.
Yamamoto, K.R., and Alberts, B.M. (1972) In vitro conversion of estradiol-receptor
protein to its nuclear form: dependence on hormone and DNA. Proc. Natl. Acad. Sci.
USA 69, 2105-2109.
Yamamoto, K.R. (1973) In vitro studies on the estradiol receptor protein and its
interaction with DNA. Ph.D. Dissertation, Princeton University.
Yamamoto, K.R., and Alberts, B.M. (1974) On the specificity of the binding of the
estradiol receptor protein to deoxyribonucleic acid. J. Biol. Chem. 249, 7076-7086.
Yamamoto, K.R. (1974) Characterization of the 4 S and 5 S forms of the estradiol
receptor protein and their interaction with deoxyribonucleic acid. J. Biol. Chem. 249,
7068-7075.
Yamamoto, K.R., Stampfer, M.R., and Tomkins, G.M. (1974) Receptors from
glucocorticoid- sensitive lymphoma cells and two classes of insensitive clones: physical
and DNA-binding properties. Proc. Natl. Acad. Sci. USA 71, 3901-3905.
Yamamoto, K.R., and Alberts, B.M. (1975) The interaction of estradiol-receptor protein
with the genome: an argument for the existence of undetected specific sites. Cell 4, 301310.
Ringold, G.M., Yamamoto, K.R., Tomkins, G.M., Bishop, J.M., and Varmus, H.E. (1975)
Dexamethasone mediated induction of mouse mammary tumor virus RNA: a system for
studying glucocorticoid action. Cell 6, 299-305.
Yamamoto, K.R., and Alberts, B.M. (1976) Steroid receptors: elements for modulation
of eukaryotic transcription. Ann. Rev. Biochem. 45, 721-746.
Yamamoto, K.R., Gehring, U., Stampfer, M.R., and Sibley, C.H. (1976) Genetic
approaches to steroid hormone action. Rec. Prog. Horm. Res. 32, 3-32.
Coffino, P., and Yamamoto, K.R. (1976) Somatic genetic studies of steroid and cyclic
AMP receptors. In: “Control Mechanisms in Cancer,” (W.E. Criss, T. Ono, and J.R.
Sabine, eds.), Raven Press, New York, pp. 57-66.
Ringold, G.M., Cardiff, R.D., Varmus, H.E., and Yamamoto, K.R. (1977) Infection of
cultured rat hepatoma cells by mouse mammary tumor virus. Cell 10, 11-18.
Ringold, G.M., Yamamoto, K.R., Shank, P.R., and Varmus, H.E. (1977) Mouse
mammary tumor virus DNA in infected rat cells: characterization of unintegrated
forms. Cell 10, 19-26.
Ringold, G.M., Yamamoto, K.R., Bishop, J.M., and Varmus, H.E. (1977) Glucocorticoid
stimulated accumulation of mouse mammary tumor virus RNA: increased rate of
synthesis of viral RNA. Proc. Natl. Acad. Sci. USA 74, 2879-2883.
Yamamoto, K.R., and Ringold, G.M. (1978) Glucocorticoid regulation of mammary
tumor virus gene expression. In: “Receptors and Hormone Action,” Vol. 2, (B.W.
O'Malley and L. Birnbaumer, eds.), Academic Press, New York, pp. 297-322.
Yamamoto, K.R., Ivarie, R.D., Ring, J., Ringold, G.M., and Stallcup, M.R. (1978)
Integrated mammary tumor virus genes: transcriptional regulation by glucocorticoids
and specific effects on host gene expression. In: “Biochemical Actions of Hormones,”
Vol. 5, (G. Litwack, ed.), Academic Press, New York, pp. 373-395.
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Sibley, C.H., and Yamamoto, K.R. (1979) Mouse lymphoma cells: mechanisms of
resistance to glucocorticoids. In: “Glucocorticoid Hormone Action,” (J.D. Baxter and
G.G. Rousseau, eds.), Springer-Verlag, Berlin, Heidelberg, pp. 253-278.
Varmus, H.E., Ringold, G.M., and Yamamoto, K.R. (1979) Regulation of mouse
mammary tumor virus gene expression by glucocorticoid hormones. In:
“Glucocorticoid Hormone Action,” (J.D. Baxter and G.G. Rousseau, eds.), SpringerVerlag, Berlin, Heidelberg, pp. 253-278.
Yamamoto, K.R., Stallcup, M.R., Ring, J., and Ringold, G.M. (1978) Mammary tumor
virus DNA: a glucocorticoid-responsive transposable element. Cold Spring Harb.
Symp. Quant. Biol. 42, 625-638.
Ringold, G.M., Cohen, J.C., Ring, J., Shank, P.R., Varmus, H.E., and Yamamoto, K.R.
(1978) Mouse mammary tumor virus genes: regulation of expression by glucocorticoids
and structural analysis with restriction endonucleases. J. Toxicol. and Environ. Health
4, 457-470.
Ringold, G.M., Shank, P.R., and Yamamoto, K.R. (1978) Production of unintegrated
mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action
of dexamethasone. J. Virol. 26, 93-101.
Stallcup, M.R., Ring, J., and Yamamoto, K.R. (1978) Synthesis of mouse mammary
tumor virus ribonucleic acid in isolated nuclei from cultured mammary tumor cells.
Biochem. 17, 1515-1521.
Shank, P.R., Cohen, J.C., Varmus, H.E., Yamamoto, K.R., and Ringold, G.M. (1978)
Mapping of linear and circular forms of mouse mammary tumor virus DNA with
restriction endonucleases: evidence for a large specific deletion occurring at high
frequency during circularization. Proc. Natl. Acad. Sci. USA 75, 2112-2116.
Varmus, H.E., Cohen, J.C., Shank, P.R., Ringold, G.M., Yamamoto, K.R., Cardiff, R., and
Morris, V.L. (1978) The endogenous and acquired proviruses of mouse mammary
tumor virus. In: “Persistent Viruses,” Vol. 2, ICN-UCLA Symposia on Molecular and
Cellular Biology, (J. Stevens, G.J. Todaro, and C.F. Fox, eds.), Academic Press, New
York, pp. 161-179.
Stallcup, M.R., Ring, J.C., Ucker, D.S., and Yamamoto, K.R. (1979) Mammary tumor
virus genes: probes for mechanisms of transcriptional regulation. In: “Hormones and
Cell Culture,” Vol. 6, Cold Spring Harbor Conference on Cell Proliferation, (G. Sato and
R. Ross, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York,
pp. 919-936.
Ringold, G.M., Shank, P.R., Varmus, H.E., Ring, J., and Yamamoto, K.R. (1979)
Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma
cells. Proc. Natl. Acad. Sci. USA 76, 665-669.
Yamamoto, K.R., Chandler, V.L., Ross, S.R., Ucker, D.S., Ring, J.C., and Feinstein, S.C.
(1981) Integration and activity of mammary tumor virus genes: regulation by hormone
receptors and chromosomal position. Cold Spring Harbor Symp. Quant. Biol. 45, 687697.
Payvar, F., Wrange, Ö., Carlstedt-Duke, J., Okret, S., Gustafsson, J.-Å., and Yamamoto,
K.R. (1981) Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA
fragment whose transcription is regulated by glucocorticoids in vivo. Proc. Natl. Acad.
Sci. USA 78, 6628-6632.
Ucker, D.S., Ross, S.R., and Yamamoto, K.R. (1981) Mammary tumor virus DNA
contains sequences required for its hormone regulated transcription. Cell 27, 257-266.
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Feinstein, S.C., Ross, S.R., and Yamamoto, K.R. (1982) Chromosomal position effects
determine transcriptional potential of integrated mammary tumor virus DNA. J. Mol.
Biol. 156, 549-565.
Firestone, G.L., Payvar, F., and Yamamoto, K.R. (1982) Glucocorticoid regulation of
protein processing and compartmentalization. Nature 300, 221-225.
Payvar, F., Firestone, G.L., Ross, S.R., Chandler, V.L., Wrange, Ö., Carlstedt-Duke, J.,
Gustafsson, J.-Å., and Yamamoto, K.R. (1982) Multiple specific binding sites for
purified glucocorticoid receptors on mammary tumor virus DNA. J. Cell. Biochem. 19,
241-247.
Yamamoto, K.R., Payvar, F., Firestone, G.L., Maler, B., Wrange, Ö., Carlstedt-Duke, J.,
Gustafsson, J.-Å., and Chandler, V.L. (1983) Biological activity of cloned mammary
tumor virus DNA fragments that bind purified glucocorticoid receptor protein in vitro.
Cold Spring Harbor Symp. Quant. Biol. 47, 977-984.
Ucker, D.S., Firestone, G.L., and Yamamoto, K.R. (1983) Glucocorticoids and
chromosomal position modulate MTV transcription by affecting the efficiency of
promoter utilization. Molec. Cell. Biol. 3, 551-561.
Chandler, V.L., Maler, B.A., and Yamamoto, K.R. (1984) Are glucocorticoid receptor
binding domains regulable “enhancer” elements? In: “Gene Transfer and Cancer,”
(M.L. Pearson and N.L. Sternberg , eds.), Raven Press, New York, pp. 303-310.
Baumann, H., Firestone, G.L., Burgess, T.L., Gross, K.W., Yamamoto, K.R., and Held,
W.A. (1983) Dexamethasone regulation of a1-acid glycoprotein and other acute phase
reactants in rat liver and hepatoma cells. J. Biol. Chem. 258, 563-570.
Firestone, G.L., and Yamamoto, K.R. (1983) Two classes of mutant mammary tumor
virus- infected HTC cells with defects in glucocorticoid-regulated gene expression.
Molec. Cell. Biol. 3, 149-160.
Chandler, V.L., Maler, B.A., and Yamamoto, K.R. (1983) DNA sequences bound
specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone
responsive in vivo. Cell 33, 489-499.
Yamamoto, K.R., Maler, B.A., and Chandler, V.L. (1983) Fusions of a glucocorticoid
response element to the tk promoter region: hormone regulated enhancement of
transcription initiation. In: “Enhancers and Eukaryotic Gene Expression,” (Y. Gluzman
and T. Shenk, eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York,
pp. 165-169.
Yamamoto, K.R. (1983) Transcriptional enhancement by specific regulatory protein:
DNA complexes. In: “Transfer and Expression of Eukaryotic Genes,” (H.S. Ginsberg
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recruitment by NFB to effect promoter specific transcriptional repression. Genes Dev.
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Van Gilst, M.R., Hadjivassiliou, H. and Yamamoto, K.R. (2005) A Caenorhabditis elegans
nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl.
Acad. Sci. USA 102, 13496-13501.
Wang, J-C., Shah, N., Pantoja, C., Meijsing, S.H., Ho, J.D., Scanlan, T.S., Yamamoto, K.R.
(2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor
regulatory activity. Genes Dev. 20, 689-699.
Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. (2006) A Mediator subunit,
MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and independent pathways in C. elegans. Genes Dev. 20, 1137-1149.
Feldman, B.F., Streeper, R.S., Farese, R.V. Jr. and Yamamoto, K.R. (2006) Myostatin
modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc.
Natl. Acad. Sci. USA 103, 15675-15680.
Meijsing, S.H., Elbi, C., Luecke, H.F., Hager, G.L., and Yamamoto, K.R. (2007) The
ligand binding domain controls glucocorticoid receptor dynamics independent of
ligand release. Mol. Cell. Biol. 27, 2442-2451.
Ricketson, D., Hostick, U., Fang, L., Yamamoto, K.R., and Darimont, B. (2007) A
conformational switch in the ligand binding domain regulates the dependence of the
glucocorticoid receptor on Hsp90. J. Mol. Biol. 368, 729-741.
So, A.Y., Chaivorapol, C., Bolton, E.C., Li, H., and Yamamoto, K.R. (2007) Determinants
of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor.
PloS Genetics 3, e94.
Bolton, E.C., So, A.Y., Chaivorapol, C., Haqq, C.M., Li, H. and Yamamoto. K.R. (2007)
Cell- and Gene-Specific Regulation of Primary Target Genes by the Androgen Receptor.
Genes Dev. 21, 2005-2017.
Woodruff, P.G., Boushey, H.A., Dolganov, G.M., Barker, C.S., Yang, Y.H., Donnelly, S.,
Ellwanger, A., Sidhu, S.S., Dao-Pick, T.P., Pantoja, C., Erle, D.J., Yamamoto, K.R., Fahy,.
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J.V. (2007) Genome-Wide Profiling Identifies Epithelial Cell Genes Associated With
Asthma and With Treatment Response to Corticosteroids. Proc. Natl. Acad. Sci. USA
104, 15858-15863.
Taubert, S., Hansen, M., Van Gilst, M.R., Cooper, S.M., Yamamoto, K.R. (2008) The
Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material. PLoS
Genetics 4, e1000021.
So, A.Y., Cooper, S.B., Feldman, B.J., Manuchehri, M., Yamamoto, K.R. (2008)
Conservation Analysis Predicts In Vivo Occupancy of Glucocorticoid Receptor Binding
Sequences at Glucocorticoid-Induced Genes. Proc. Natl. Acad. Sci. USA 105, 5745-5749.
Pantoja, C., Huff, J.T., Yamamoto, K.R. (2008) Glucocorticoid Signaling Defines a Novel
Commitment State during Adipogenesis In Vitro. Mol. Biol. Cell. 19, 4032-41.
Meijsing, S.H., Pufall, M.A., So, A.Y., Bates, D.L., Chen, L., Yamamoto, K.R. (2009) DNAbinding site sequence directs glucocorticoid receptor structure and activity. Science
324, 407-410.
Jones, J.O., Bolton, E.C., Huang, Y., Feau, C., Guy, R.K., Yamamoto, K.R., Hann B.,
Diamond M.I. (2009) Non-competitive androgen receptor inhibition in vitro and in vivo.
Proc. Natl. Acad. Sci. U S A. 106, 7233-7238.
Beck, I.M.E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K.R., Haegeman, G.*, De
Bosscher, K*. (*Share senior authorship) (2009) Crosstalk in Inflammation: The interplay
of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocrine
Reviews 30, 830-82.
So, A.L., Bernal, T.U., Pillsbury, M.L., Yamamoto, K.R., Feldman, B.J. (2009)
Glucocorticoid Regulation of the Circadian Clock Modulates Glucose Homeostasis.
Proc. Natl. Acad. Sci. U S A. 106, 17582-7.
Taubert, S., Ward, J.D., Yamamoto, K.R. (2010) Nuclear Hormone Receptors in
Nematodes: Evolution and Function. Mol. Cell. Endocrinol. 334, 49-55.
Arda, H.E., Taubert, S., MacNeil, L.T., Conine, C., Tsuda, B., van Gilst, M., Sequerra, R.,
Doucette-Stamm, L., Yamamoto, K.R., Walhout, A.J.M. (2010) Functional modularity of
nuclear hormone receptors in a C. elegans metabolic gene regulatory network. Molecular
Systems Biology 6: 367.
Dekelver, R.C., Choi, V.M., Moehle, E.A., Paschon, D.E., Hockemeyer, D., Meijsing, S.H.,
Sancak, Y., Cui, X., Steine, E.J., Miller, J.C., Tam, P., Bartsevich, V.V., Meng, X.,
Rupniewski, I., Gopalan, S.M., Sun, H.C., Pitz, K.J., Rock, J.M., Zhang, L., Davis, G.D.,
Rebar, E.J., Cheeseman, I.M., Yamamoto, K.R., Sabatini, D.M., Jaenisch, R., Gregory,
P.D., Urnov, F.D. (2010) Functional genomics, proteomics, and regulatory DNA analysis
in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor
locus in the human genome. Genome Res. 20, 1133-42.
Huff, J.T., Plocik, A.M., Guthrie, C., Yamamoto, K.R. (2010) Reciprocal intronic and
exonic histone modification regions in humans. Nat. Struct. Mol. Biol. 17, 1495-9.
Costa, M.J., So, A.Y., Kaasik, K., Krueger, K.C., Pillsbury, M.L., Fu, Y.H., Ptacek, L.J.,
Yamamoto, K.R., Feldman, B.J. (2011) Circadian rhythm gene period 3 is an inhibitor of
the adipocyte cell fate. J. Biol. Chem. 286, 9063-70.
Cvoro, A., Yuan, C., Paruthiyil, S., Miller, O.H., Yamamoto, K.R., Leitman, D.C. (2011)
Cross Talk between Glucocorticoid and Estrogen Receptors Occurs at a Subset of
Proinflammatory Genes. J Immunol. 186, 4354-60.
Ou, C.-Y., LaBonte, M.J., Manegold, P.C., So, A. L., Ianculescu, I., Gerke, D.S.,
Yamamoto, K.R., Ladner, R.D., Kahn, M., Kim, J.-H., Stallcup, M.R. (2011) A coactivator
role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth
and gene expression. Mol. Cancer Res. 9, 660-70.
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Holdorf, M.M., Cooper, S.B., Yamamoto, K.R., Miranda, J.J. (2011) Occupancy of
chromatin organizers in the Epstein-Barr virus genome. Virology. 415, 1-5.
Engel K.B., Yamamoto K.R. (2011) The glucocorticoid receptor and the coregulator Brm
selectively modulate each other’s occupancy and activity in a gene-specific manner.
Mol. Cell. Biol. 31, 3267-76.
Ziv, L., Muto, A., Schoonheim, P.J., Meijsing, S.H., Strasser, D., Ingraham, H.A., Schaaf,
M.J.M., Yamamoto, K.R., Baier, H. (2012) An affective disorder in zebrafish with
mutation of the glucocorticoid receptor. Mol. Psychiatry. doi: 10.1038/mp.2012.64.
[epub ahead of print]
Chen, S.-H., Masuno, K., Cooper, S., Yamamoto, K.R. (2013) An incoherent feed-forward
regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci USA.
110, 1964-9.
Watson, L.C., Kuchenbecker, K.M., Schiller, B.J., Gross, J.D., Pufall, M.A., Yamamoto,
K.R. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequencespecific DNA signals. Nature Struc Mol Biol. 20, 876-83.
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and processing of mouse mammary tumor virus glyco-proteins in MTV-infected rat
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recessive lethal deletion on mouse chromosome 7 affects glucocorticoid receptor
binding activities. Proc. Natl. Acad. Sci. USA 80, 1431-1434.
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variant mouse lymphoid cells with altered glucocorticoid responsiveness. Molec. Cell.
Biol. 3, 1310-1316.
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by purified intact and protease-cleaved glucocorticoid receptor. In: “Steroid Hormone
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Gustafsson, eds.), Elsevier/North Holland Biomedical Press, Amsterdam, pp. 267-282.
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glucocorticoid receptor mRNA in human leukemia cells: stabilization of the receptor by
diisopropylfluorophosphate. Blood 69, 750-756.
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Logsdon, C.D. (1988) Mechanism of glucocorticoid receptor down-regulation by
glucocorticoids. J. Biol. Chem. 263, 2581-2584.
Miesfeld, R.L. (1989) The structure and function of steroid receptor proteins. CRC Crit.
Rev. Biochem. 24, 101-117.
Schena, M. (1989) The evolutionary conservation of eukaryotic gene transcription.
Experientia 45, 972-983.
Godowski, P.J. and Picard, D. (1989) Steroid receptors: how to be both a receptor and a
transcription factor. Biochem. Pharmacol. 38, 3135-3143.
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binding domain of the mammalian glucocorticoid receptor. Biochem. 29, 9218-9225.
Superti-Furga, G., Bergers, G., Picard, D., and Busslinger, M. (1991) Hormonedependent transcriptional regulation and cellular transformation by Fos-steroid receptor
fusion proteins. Proc. Natl. Acad. Sci. USA 88, 5114-5118.
Byravan, S., Milhon, J., Rabindran, S.K., Olinger, B., Garabedian, M.J., Danielsen, M. and
Stallcup, M.R. (1991) Two point mutations in the hormone-binding domain of the
mouse glucocorticoid receptor that dramatically reduce its function. Mol. Endocrinol.
5, 752-758.
DeFranco, D.B., Qi, M., Borror, K.C., Garabedian, M.J. and Brautigan, D.L. (1991)
Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of
glucocorticoid receptors. Mol. Endocrinol. 5, 1215-1228.
Garabedian, M.J., LaBaer, J., Liu, W.-H. and Thomas, J.R. (1993) Analysis of proteinDNA interactions. In: “Practical Approaches to Eukaryotic Gene Transcription,” (B.D.
Hames and S. Higgins, eds.), IRL Press, Oxford, U.K., pp. 243-293.
Pearce, D. (1994) A mechanistic basis for distinct mineralocorticoid and glucocorticoid
receptor transcriptional specificities. Steroids 159, 153-159.
Garabedian, M.J. (1993) Genetic approaches to mammalian nuclear receptor function in
yeast. Methods 6, 1-9.
Bohen, S.P. (1995) HSP90 Mutants disrupt glucocorticoid receptor ligand binding and
destabilize aporeceptor complexes. J. Biol. Chem. 270, 29433-29438.
Lamarco, K. and Vivanco, M.D.M. (1996) Steroid hormone and nuclear receptors. In:
"Signal Transduction," (C-H. Helden and M. Purtin, eds.), Chapman & Hall, London,
pp. 305-320.
Meyer, T., Starr, D.B. and Carlstedt-Duke, J. (1997) The rat glucocorticoid receptor
mutant K461A differentiates between two different mechanisms of transrepression. J.
Biol. Chem. 272, 21090-21095.
Meyer, T., Carlstedt-Duke and J., Starr, D.B. (1997) A weak TATA box is a prerequisite
for glucocorticoid-dependent repression of the osteocalcin gene. J. Biol. Chem. 272,
30709-30714.
Tang, Y., Ramakrishnan, C., Thomas, J. and DeFranco, D.B. (1997) A role for HDJ2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression
defects of a glucocorticoid receptor zinc finger mutant. Mol. Biol. Cell. 8, 795-809.
Pocuca, N., Ruzdijic, S., Demonacos, C., Kanazir, D. and Krstic-Demonacos, M. (1998)
Using yeast to study glucocorticoid receptor phosphorylation. J. Steroid Biochem.
Molec. Biol. 66, 303-318.
Hammer,G.D., Krylova, I., Zhang, Y., Darimont, B.D., Simpson, K., Weigel, N.L. and
Ingraham, H.A. (1999) Phosphorylation of the nuclear receptor SF-1 modulates cofactor
recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3,
521-526.
Darimont, B.D. (1999) The Hsp90 chaperone complex–A potential target for cancer
therapy? World Journal of Gastroenterology 5, 195-198.
Hittelman, A.B., Burakov, D., Iñiguez-Lluhí, J.A., Freedman, L.P. and Garabedian, M.J.
(1999) Differential regulation of glucocorticoid receptor transcriptional activation via
AF-1-associated proteins. EMBO J. 18, 5380-5388.
Iniguez-Lluhi, J.A. and Pearce, D. (2000) A common motif within the negative
regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell.
Biol. 15, 6040-6050.
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Bland, M.L., Jamieson,C.A.M., Akana,S.F., Bornstein,S.R., Eisenhofer,G., Dallman,M.F.
and Ingraham,H.A. (2000) Haploinsufficiency of steroidogenic factor-1 in mice disrupts
adrenal development leading to an impared stress response. Proc. Natl. Acad. Sci. USA
97, 14488-14493.
Barboric, M., Nissen, R.M., Kanazawa, S., Jabrane-Ferrat, N. and Peterlin, B.M. (2001)
NF-B binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.
Mol. Cell. 8, 327-337.
Welch, W.J. and Diamond, M.I. (2001) Glucocorticoid modulation of androgen receptor
nuclear aggregation and cellular toxicity is associated with distinct forms of soluble
expanded polyglutamine protein. Human Molecular Genetics 10, 3063-3074.
Rogatsky, I. (2003) Drug discovery for inflammatory diseases. Expert Opin. Biol. Ther.
3, 1-4.
Van Gilst, M., Gissendanner, C.R., Sluder, A.E. (2002) Diversity and function of orphan
nuclear receptors in nematodes. Crit Rev Eukaryot Gene Expr. 12, 65-88.
Wang, J-C. (2005) Finding Primary Targets of Transcriptional Regulators. Cell Cycle 4,
356-358.
Reily, M.M., Pantoja, Hu, C.X., Chinenov, Y. and Inez Rogatsky (2006) The GRIP1:IRF3
interaction as a target for glucocorticoid receptor-mediated immunosuppression.
EMBO J. 25, 108–117.
Takayama, S., Rogatsky, I., Schwarcz, L.E. and Darimont, B.D. (2006) The
glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex. J.
Biol. Chem. 281, 17856-17863.
Feldman, B.J. (2007) Is Your Metabolism Determined By (Cell) Fate? Pediatric
Research 61, 636-639.
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regulation of lipid metabolism by novel nuclear receptor partnerships. PLoS Genetics 8,
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BOOKS EDITED
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Goldberger, R.F., and Yamamoto, K.R., eds. (1982) “Biological Regulation and
Development, Vol. 3A, Hormone Action,” Plenum Press, New York.
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Development, Vol. 3B, Hormone Action,” Plenum Press, New York.
McKnight, S.L., and Yamamoto, K.R., eds. (1992) “Transcriptional Regulation,” Cold
Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
SCIENCE AND PUBLIC POLICY PUBLICATIONS
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Yamamoto, K.R. (1982) Faculty members as corporate officers: does cost outweigh
benefit? In: “From Genetic Experimentation to Biotechnology — The Critical
Transition,” (W.J. Whelan and S. Black, eds.), John Wiley & Sons, Limited, Chichester,
Sussex, England, pp. 195-201.
Piller, C., and Yamamoto, K.R. (1988) “Gene Wars: Military Control Over the New
Genetic Technologies,” Beech Tree/William Morrow, New York.
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Yamamoto, K.R. (1989) Retargeting research on biological weapons. Technol. Rev. 92,
23-24.
Yamamoto, K.R. (1989) Should germ warfare defense funds be transferred to NIH? J.
NIH Research 1, 18-20.
Yamamoto, K.R. (1992) Second thoughts on misconduct. J. NIH Res. 4, 18.
Yamamoto, K.R., and Marincola, E. (1993) NIH’s strategic plan: From whom? To
whom? Why now? J. NIH Res. 5, 26-28.
Yamamoto, K.R. (1997) Placing the Ph.D. at the hub of career development in the
biological sciences. In: "Graduate Education in the Biological Sciences in the 21st
Century: Meeting the Challenge," (S. Huttner and J. Rubaloff, eds.) University of
California Systemwide Biotechnology Research and Education Program, Berkeley,
California, pp. 144-155.
Alberts, B.M., Ayala, F.J., Botstein, D., Frank, E., Holmes, E.W., Lee, R.D., Macagno, E.R.,
Marrack, P., Oparil, S., Orkin, S.H., Rubenstein, A.H., Slayman, C.W., Sparling, P.F.,
Squire, L.R., von Hippel, P.H. and Yamamoto, K.R. (1999) Proposed changes for NIH's
Center for Scientific Review. Science 285, 666-667.
Yamamoto,K.R. (interview) (2000) How to use electroninc publishing to enhance your
science. ASCB Newsletter 23 (10), 3-5.
Lo, B., Chou,V., Cedars, M.I., Gates, E., Taylor, R.N., Wolf, L., Wagner, R.M. and
Yamamoto, K.R. (2003) Informed consent from gamete donors. Science 301, 921.
Walter, P. and Yamamoto, K.R. (2003) In memory of Ira Herskowitz. The ASCB
Newsletter 26 (6), 18.
Lo, B., Chou, V., Cedars, M.I., Gates, E., Taylor, R.N., Wagner, R.M., Wolf, L. and
Yamamoto, K.R. (2004) Informed consent in human oocyte, embryo, and embryonic
stem cell research. Fertil Steril 82, 559-563.
Yamamoto, K.R. (2004) Bankrolling Stem-Cell Research with California Dollars. NEJM
351, 1711-1713.
Lo, B., Zettler, P., Cedars, M.I., Gates, E. Kriegstein, A.R., Oberman, M., Reijo Pera, R.,
Wagner, R.M., Wuerth, M.T., Wolf, L.E., Yamamoto, K.R. (2005) A New Era in the
Ethics of Human Embryonic Stem Cell Research. Stem Cells 23, 1454-1459.
Kriegstein, A. and Yamamoto, K.R. (2006) Op-Ed: Stem-cell research on the rise, even
lacking government funds. San Francisco Chronicle, February 3, 2006.
Committee on Bridges to Independence, National Research Council (US). 2005. Bridges
to Independence: Fostering the Independence of New Investigators in Biomedical Research.
National Academies Press. Washington, DC, USA. 172 pp.
Committee on Alternative Models for the Federal Funding of Science (US). 2008. ARISE
(Advancing Research in Science and Engineering): Investing in Early-Career Scientists and
High-Risk, High-Reward Research. White paper.
Committee on a New Biology for the 21st Century: Ensuring the United States Leads the
Coming Biology Revolution, National Research Council of the National Academies
(US). 2009. A New Biology for the 21st Century. The National Academies Press.
Labov, J.B., Reid, A.H., Yamamoto K.R. (2010) Integrated Biology and Undergraduate
Science Education: A New Biology for the Twenty First Century? CBE Life Sci Educ 9,
10-6.
Norman, T.C., Bountra, C., Edwards, A.M., Yamamoto, K.R., Friend, S.H. (2011)
Leveraging crowdsourcing to facilitate the discovery of new machines. Sci. Transl.
Med. 3, 88mr1.
Hood, L.E., Omenn, G.S., Moritz, R.L., Aebersold, R., Yamamoto, K.R., Amos, M.,
Hunter-Cevera, J., Locascio, L. (2012) New and improved proteomics technologies for
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understanding complex biological systems: Addressing a grand challenge in the life
sciences. Proteomics 12, 2773-2783.
O’Brien, T.C., Yamamoto, K.R., Hawgood, S. (2013) Team Science (Commentary).
Academic Medicine 88, 156-7.
Yamamoto, K.R. (2013) “Time to Play Ball.” Editorial. Science 340:1375.
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PATENTS
U.S. Patent No. 4,889,802 Enhanced Production of Recombinant Proteins in Myeloma Cells
(T.J. Parslow, K.R. Yamamoto) December 26, 1989.
U.S. Patent No. 5,215,916 Super glucocorticoid receptors: receptors with increased affinity and
specificity for glucocorticoid steriods. S.S Simons, Jr., P.K. Chakraborti, K.R. Yamamoto,
M.J. Garabedian. June 1, 1993.
U.S. Patent No. 5,631,133 Transition in Transcriptional Activation by Intracellular Hormone
Receptors at the Tumor Stage of Dermal Fibrosarcoma Development (D. Hanahan, M.d.M.
Vivanco, K.R. Yamamoto) May 20, 1997.
U.S. Patent Application No. 20020061539 Methods and Compounds for Modulating Nuclear
Receptor Coactivator Binding. (J.D. Baxter, B.D. Darimont, W. Feng, R.J. Fletterick P.J.
Kushner, R.L. Wagner, B.L. West, K.R. Yamamoto). Filed March 30, 1999.
Canadian Patent Application No. 2323575 Methods and Compounds for Modulating
Nuclear Receptor Coactivator Binding. (B.D. Darimont, R.J. Fletterick, J.D. Baxter, W. Feng,
P.J. Kushner, B.L. West, R.L. Wagner, K.R. Yamamoto). March 30, 1999.
Canadian Patent Application No. 2415103 Methods and Compounds for Modulating
Nuclear Receptor Coactivator Binding. (B.D. Darimont, R.J. Fletterick, T.R. Geistlinger, J.D.
Baxter, W. Feng, I. Kuntz, J.R. Arnold, R. K. Guy, P.J. Kushner, B.L. West, R.L. Wagner,
K.R. Yamamoto). June 29, 2001.
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