MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. Brief Study Guide for Exam Preparation - In preparation for the scheduled exams (see syllabus) make yourself very familiar with following terms, key topics and concepts the listed units and chapters refer to the lecture course-required textbook Exam 1: Chapter 1 Know: 1. The pursuit of biological science and its important sub-disciplines, e.g. biochemistry, genetics, cytology, molecule biology. 2. The difference between a hypothesis, theory and principle in scientific inquiry. 3. The meaning of deductive and inductive approach in science. 4. The importance of (positive and negative) controls in scientific experiments. 5. What is meant with empirical and reductionistic approach in science? 6. The 3 different domains and kingdoms of life and their main characteristics 7. The 7 main characteristics of living systems Chapter 2: The chemical Basis of Life Know: 1. The definition of matter 2. The names and abbreviations of the 6 most abundant chemical elements in living organisms 3. What are typical trace elements for living systems? 4. The names and nature of the subatomic components of chemical elements (= electron, proton and neutron) and how they relate to atomic number and atomic mass number 5. Be familiar with the core statements of the atomic theory, know Bohr’s atomic model 6. Be familiar with the rule of eight (=octet rule) and how it relates to covalent and ionic bond formation. What is meant with “noble gas configuration”? 7. The Bohr model of the carbon atom, understand the term sp3 hybrid orbital and how it explains the tetrahedral structure of the carbon atom, 8. The electron shells, trace elements, differences: ionic bond, covalent bond, hydrogen bond, octet rule 9. isotopes: definition, examples, e.g. 14C Chapter 3: Molecules of the Cell: 1. Know that water is a polar molecule and be able to explain why: - chemical structure, properties of water, including heating capacity, adhesion, cohesion, capillarity, explanation for water’s polarity (difference in electronegativity numbers of hydrogen and oxygen) - Consequences of polarity hydrogen bond formation - Significance of hydrogen bond formation for living organsisms 2. Know the meaning of functional groups and be able to name examples, e.g. hydroxyl group - know the functional groups in the four important carbon-based classes of biomolecules = carbohydrates, fatty acids, amino acids and nucleotides - be able to explain dehydration synthesis, monomer, polymer formation 1 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 3. Know examples and biological functions of important monosaccharides and polysaccharides, e.g. cellulose, glycogen, starch 4. What are lipids and fats? Structures and functions, Differences: hydrophilic, hydrophobic, polar, unpolar, 5. What are steroids? Know important examples and their biological functions. 6. What are amino acids? Know examples, similarities and R-group differences, peptide bond formation, primary structure, secondary structure, tertiary structure, quartenary structure, forces and mechanisms mediating protein-protein interactions (Van der Waals, disulfide bond formation), X-ray crystallography and study of proteins 7. What are nucleotides? What are nucleic acids? Know the differences between RNA and DNA, regarding composition, structure and location, rehearse the structure of the DNA double helix, 8. Know examples and biological functions of important cellular signaling molecules, such as insulin, adrenaline, plant auxines, nitric oxide. Exam 2: Chapter 4: A Tour of the Cell Know: 1. the basic statements of the cell theory 2. the major differences between prokaryotic and eukaryotic cells 3. examples of prokaryotic and eukaryotic cells 4. the major organelles of eukaryotic cells and their unique biological function within the cell (incl. rER, sER, Golgi apparatus, mitochondrion, chloroplast, lysosome, peroxisome) 5. the path of a newly synthesized protein from the point of origin (= ribosome) to the surface of a cell 6. the core statements of the endosymbiotic theory and rehearse the evidences which support it 7. the three major fibrous protein components of the cytoskeleton and its monomeric proteins 8. at least one biological function of the microfilaments, microtubules and of the intermediate fibers 9. the difference and similarities between cilia, flagella and villi Chapter 5: Energy & The Working Cell Know: 1. the two laws of energy 2. the definition for energy 3. the different forms of energy and their manifestation in biological organism (name at least one example for each form of energy) 4. the difference between an endergonic and exergonic chemical reaction 5. the meaning of “free energy coupling” in living organisms 6. the three major components of the ATP molecule 7. the exergonic chemical reaction ATP undergoes to release free energy 8. the abbreviation for redox 9. the difference between oxidation and reduction 2 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 10. the structures and functions of important cellular redox molecules as they apply to catabolic and anabolic chemical reactions (incl. NAD+, NADP+, FAD, ubiquinone, heme-iron, iron-sulfur) 11. important examples and the function of cellular antioxidants, incl. vitamin E and vitamin C 12. the chemistry of dehydrogenation reactions and the function of dehydrogenase enzymes Chapter 6(pp96-103): Enzymes 1. Know what enzymes are made up from, what they are doing in living organisms 2. Know how the terms: activation energy, active site, co-factors, co-substrates, substrate, product, relate to enzymes and enzyme function 3. Know the different forms of enzyme inhibition (feedback, competitive, non-competitive, allosteric) and be able to name prominent examples of enzyme inhibitors (heavy metals, aspirin, ibuprofen) 4. Rehearse how knowledge about enzymes relates to toxicology, experimental drug design and drug testing Chapter 6: Cellular Respiration 1. Be able to explain the meaning heterotrophic 2. Know the difference between aerobic and anaerobic respiration 3. Know how physiological respiration (breathing) relates to cellular respiration 4. Be able to write down the net equation of cellular respiration (input versus output) 5. Know the cellular location of glycolysis 6. Know the cellular uptake mechanism for glucose and the important role of the hormone insulin 7. Be able to name the first glycolytic enzyme = hexokinase/glucokinase and the chemical reaction it catalyses 8. Know the end product of the preparative phase of glycolysis by name; how many carbon atoms does it have? 9. Know the final end product of glycolysis by name; how many carbon atoms does it have? 10. Know the net ATP production number of glycolysis per one molecule of glucose 11. Know how many NADH + H+ molecules are generated during glycolysis for each molecule of glucose catabolized 12. Rehearse the chemical reaction which links glycolysis with the Krebs cycle; also rehearse the role of the enzyme (= pyruvate dehydrogenase) which catalyses this important step 13. Be able to name the first chemical reaction and the first chemical product of the Krebs cycle 14. Know how many NADH + H+ as well as FADH2 molecules are generated per each cycle of the Krebs cycle 15. Be sure you know where within a cell the Krebs cycle takes place 16. Understand the role of the molecule coenzyme A within the Krebs cycle 17. Know at which step of the Krebs cycle ATP is generated; how many molecules per cycle? 18. Know the enzymatic step within the Krebs cycle where FADH2 is generated and name the enzyme which catalyses this unique chemical reaction 3 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 19. Know the name of the carbon waste product of the Krebs cycle (= CO2) and rehearse the steps within the cycle where it is released; how many molecules per each cycle? How many molecules of carbon dioxide are released for each molecule of glucose catabolized? 20. Know the meaning of decarboxylation reaction and how it relates to the release of carbon dioxide during the Krebs cycle 21. Know the alternative name for the Krebs cycle (= citric acid cycle); where does this name come from? 22. Understand the ultimate role of the electron transport chain regarding the electron and proton-loaded redox molecules NADH + H+ and FADH2 23. Know where within the mitochondria the electron transport chain (ETC) is located 24. Rehearse the four major complexes of the ETC and their basic position within the chain; which complex becomes reduced by NADH + H+; which complex becomes reduced by FADH2 25. Be able to describe the basic statement of the chemio-osmotic theory; what does this theory explain? who developed the core idea of this theory? 26. Know the important role of ubiquinone (Q10) within the ETC; what does this mitochondrial redox molecule do? 27. Be able to name the final electron acceptor molecule of the ETC; what is the ultimate chemical end product forming at complex 4 of the ETC (think of water) 28. Know the name of the enzyme which uses the proton gradient established across the inner mitochondrial membrane to form (synthesize) ATP and rehearse the working principle of the ATP synthase enzyme 29. Know some examples of important inhibitors of the ETC and be sure you understand how their interaction with components of the ETC explains their toxicity and biohazardous nature; how does cyanide work different to a so-called uncoupler molecule, such as DNP or CCCP 30. Rehearse the consequences of lack of oxygen (anaerobic conditions) to cellular respiration (which pathways are shut down; which one is primarily used to make ATP) 31. Compare lactic acid fermentation with alcoholic fermentation regarding end products, NADH + H+ regenerating enzymes and consequences for the anaerobic cell 32. Be able to name important applications and uses of anaerobic fermentation in biotechnology, industry and our world cultures Chapter 7: Photosynthesis: Using light to make food 1. Understand the meaning phototrophic 2. Be able to name some phototrophic organisms, including cyanobacteria, diatoms and algae 3. Know the location of photosynthesis within a plant cell 4. Know the location of photosynthesis within a thylacoid 5. Know the net equation of photosynthesis! (Input – Output) 6. Be able to name the different components of a thylacoid 7. Rehearse the dual nature of light as an electromagnetic form of energy as well as a photon 8. Understand how and with which pigments light interacts during photosynthesis 9. What are chlorophylls? How many are there in green plants? 10. What means chlorophyll excitation? 11. Rehearse which qualities of light are absorbed by chlorophyll 4 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 12. Understand the difference between light and dark reaction of photosynthesis regarding location, components and products 13. What is a photosystem? (be able to name the three components) 14. How many photosystems are there in a plant cell and where are (these two) located? 15. Know the input and output of photosystem I and II 16. Know where and how ATP is generated during the light reaction of photosynthesis 17. Which enzyme do plant cells use to make ATP? 18. Know what plant cells are doing with (most) of the ATP generated during the light reaction of photosynthesis 19. Be able to name the necessary chemical components for the dark reaction (rehearse the role of ATP, carbon dioxide and NADPH + H+ in this reaction) 20. Rehearse the major steps of the Calvin-Benson cycle (CBC) as the most important chemical reaction pathway of the dark reaction 21. Know the important role of Rubisco enzyme in the CBC 22. Which chemical reaction does Rubisco enzyme catalyze? 23. Know the number of spins of the CBC to make one molecule of glucose 24. Know the name and total numbers of the 3-carbon end product of the Calvin-Benson cycle 25. Know the difference between a C3, C4 and CAM plant regarding their uptake and fixation of carbon dioxide during photosynthesis 26. Know examples for C3, C4 and CAM plants 27. Know the meaning of photorespiration and its consequences for agricultural plants 28. Rehearse the meaning “uncoupler” substance in the context of ATP production in plant cells (proton gradient destruction, inhibition of ATP synthesis, herbicides) 29. Understand how “oxidative stress”, caused by certain herbicides such as paraquat or ozone interferes with photosynthesis Exam 3: Chapter 8: Mitosis & Meiosis: The cellular basis of growth, reproduction and inheritance 1. Know the different phases of the cell cycle 2. Know how a cell can be triggered to prepare for cell division ( growth factors, hormones) 3. Know where in your own body continuous cell divisions take place (hint: skin, bone marrow) and which cells are responsible for this (hint: stem cells) 4. Be familiar with the terms: chromatin, sister chromatids, centromer, centrosome, MTOC, microtubules, kinetochore, spindle apparatus, spindle poles, cleavage furrow, actin ring 5. Be able to identify the different phases of mitosis and be able to name the major events 6. Understand how uncontrolled mitosis relates to the development of cancer 7. Know examples of mitosis blockers (hint: colchicine, taxol, vinblastine) and be able to explain why some are used for treatment of certain forms of cancer 8. Know the difference between somatic and reproductive cells regarding biological function, chromosome number 9. Be able to define and explain the terms: haploid, diploid, zygote, oocyte, spermatogonia, sperm, gonads, gametes 10. Know the major differences between plant cell and animal cell mitosis (hint: cell plate, aster, cleavage furrow) 5 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 11. Know where meiotic cell divisions (meiosis) takes place in a human male and female body; what is the name of the cell which is starting and undergoing meiosis? 12. Be able to name the key hormones in male and female humans which trigger and control meiosis (hint: FSH, testosterone, progesterone) 13. Know the major cell events during meiosis I and meiosis II 14. Be able to define and explain the terms: synapsis, tetrad formation, crossing over, recombinant chromosomes, mutation, deletion 15. Be able to name the events during meiosis which contribute to increased genetic variability 16. Know what chromosomal aberrations are and understand how they relate to “cellular accidents” during meiosis I and/or meiosis II 17. Rehearse prominent examples of human disorders that are caused by chromosomal aberrations (hint: trisomy 21, Klinefelter syndrome) 18. Be able to define the explain the terms: karyotyping, karyogram, amniocentesis, chorionic villi sampling (CVS) 19. Understand and discuss factors which may lead to chromosomal aberrations in humans Chapter 9: Genetics: Patterns of Inheritance 1. Know the name of the pioneering scientist who is considered to be the founding father of the scientific subdiscipline of genetics; With which biological organisms did he work when he discovered the fundamental laws of genetics? 2. Be able to explain the term “true-breeding” variety in the context of genetics 3. Be able to define and explain the terms: dominant, recessive, allele, monohybrid cross, dihybrid cross, homozygous, heterozygous, phenotype and genotype 4. Rehearse the core ideas and statements of Mendel’s principles (dominant/recessive alleles, allele segregation, independent assortment of alleles) 5. Know the core idea of the chromosomal theory of inheritance 6. Be able to use a Punnett square to predict the outcomes of breeding experiment and to solve genetic problems 7. Know prominent dominant and recessive heritable traits in: the garden pea (petal color, seed color), corn (kernel color, kernel shape), the fruitfly Drosophila (eye and body color) and in humans (eye color, widows peak, PTC tasting, etc.) 8. Know the meaning of incomplete dominance and be able to name prominent examples for this variation of Mendel’s principle (hint: snap dragons, orchids) 9. Understand why the observation of incomplete dominance in the inheritance of certain traits in biological organisms does not disprove Mendel’s principles of heredity (be familiar with the term “blending hypothesis” & J.B. Lamarck) 10. Be familiar with prominent examples of incomplete dominant inherited traits in humans (hint: think of too high cholesterol) 11. What is polygenic inheritance? Be able to name examples. 12. What is pleiotropy in genetics? Know at least one example in the human population. 13. What is codominance in genetics? Be able to name a prominent example in human genetics (hint: think of blood transfusion) 14. Be familiar with the genetics of the ABO blood types and the Rhesus factor. How many alleles are there for the heritable trait “blood type” in the human population? How many blood type alleles does a human individual have? 6 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 15. Be able to use a Punnett square to solve a paternity or criminal case based on the knowledge of blood types 16. Be familiar with the working principle of a typical blood test. (Know the meaning of the terms: antigen, antibody, antiserum, agglutination) 17. Understand how and why the Rhesus factor (Rh) can cause complications during pregnancy in a human female. 18. Know the difference between autosomes and sex (or gender) chromosomes 19. Know the chromosomal complement and karyotype of a human male and female 20. Know how many gender chromosomes there are in a human somatic cells and in human gametes 21. Understand the inheritance patterns of X- or sex-linked inheritance in the fruitfly Drosophila and in humans 22. Be able to name prominent examples of X-linked inherited traits and/or conditions in humans Chapter 10: DNA, DNA replication, DNA transcription and protein translation DNA Replication: 1. Rehearse the basic chemical composition and structure of DNA and RNA; know that both biological macromolecules are polynucleotides or so-called nucleic acids 2. Know the 4 nucleotides that cells use to build-up (= synthesize) DNA and RNA molecules 3. Know the names and abbreviations of the 5 nucleotides cells use to make DNA and RNA. Which nucleotides are found in DNA? Which one in RNA molecules? 4. Rehearse the role of hydrogen bonding in the formation/maintenance of the DNA double helix. Are hydrogen bonds strong or weak bonds? 5. Know during which phase of the cell cycle DNA replication occurs 6. Know where on the DNA strand in a cell DNA replication (or duplication) begins (hint: ori) 7. Know the first event during DNA replication. Which one is it and which enzyme is involved? 8. Know the name of the enzyme which adds the new nucleotides to the leading and lagging DNA strand. 9. Know the name of the short RNA snipplets/pieces which are necessary for successful initiation of DNA replication (hint: primers). Rehearse their function. Why are they needed for successful DNA replication! 10. Know the second function of the DNA polymerase enzyme during DNA replication (think of repair and control) 11. Be able to define and explain following terms: replication fork, Okazaki fragments, lagging strand, leading strand, replication bubbles, 12. Be familiar with the term “mutagen” and know some prominent examples (hint: benzo(a)pyren, nitrosamines, mustard gas); understand how certain mutagenic molecules can interfere with the normal (otherwise smoothly running) DNA replication process 13. Understand why the cellular DNA replication mechanism leads to two (almost) identical DNA daughter strands 14. Know which enzyme is responsible to guarantee a stunningly low error rate during DNA replication 15. Understand why (despite proof-reading of the copied DNA) DNA replication may lead to rare point mutations and plays a significant role in the (slow) change of genetic material 7 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. over periods of time! Discuss the contribution of replication errors happing during DNA replication to evolutionary change on planet Earth. DNA Transcription: 1. Know the definition of DNA transcription 2. What is the name of the transcribed molecule 3. Know which enzyme is responsible for DNA transcription in prokaryotic and eukaryotic cells 4. Know the place/location within a cell where DNA transcription takes place 5. Know the three phases of DNA transcription by name (hint: initiation, elongation, termination) and be able to describe the major events occurring during each of these phases 6. Know the name of the piece of RNA one observes in cells after DNA transcription. 7. Know what happens to the pre-mRNA after DNA transcription in eukaryotic cells (keyword: RNA processing) 8. What is an operon in bacterial cells? What advantage does it give bacteria? Know one prominent example of a bacterial operon (hint: think of milk and lactose) 9. Be able to define and explain following terms: intron, exon, RNA splicing, transcription factor, 10. What is the advantage of RNA splicing one observes in eukaryotic cells? 11. Rehearse the important role of the nuclear pores for the transport of mRNA out of the nucleus into the cytosol 12. Understand why mutations or dysregulation of certain transcription factors, such as myc or NFkB, can contribute to the development of cancer Protein translation & Genetic code: 1. Know the names of the three RNA molecules which are necessary for successful translation of genetic information on a gene into a protein 2. Know the place within a cell where protein translation takes place 3. Where do you find the ribosomes in eukaryotic cells? Where in bacteria? 4. Of how many protein sub-units is a ribosome made up from? 5. Know the difference between aminoacyl-tRNA and tRNA. Which of the two ones binds to the ribosome and which one usually leaves a ribosome? 6. Be able to name the three phases of protein translation (hint: initiation, elongation and termination) and know the major events at the ribosome during each of these phases. 7. Be able to define and explain following terms: P-site, A-site, small sub-unit, large sub-unit, rRNA, mRNA, codon, anti-codon, transpeptidylation reaction, releasing factor (RF), translocation 8. Who the heck was Marshall Nirenberg? What did he and his team achieve in the 1960s? 9. Understand why the genetic code of all forms of life on planet Earth is based on a triplet code and not on a binary code. (compare the genetic code of life with the binary code of computers) 10. Know how to read and interpret the genetic code table. 11. Know which amino acid is encoded by the codon ATG 12. Be able to define and explain following terms: stop codon, start codon, redundancy of the genetic code, 13. Know how many codons are actually coding for an amino acid 14. Know some famous and infamous ribosomal toxins and poisons which prevent cellular protein translation (hint: cycloheximide) 8 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 15. Understand why many bacteria target the cellular “protein translation complex” with the help of released toxins. Be able to name one. 16. Understand why and how DNA mutations, e.g. point mutations, deletions, insertions, can lead to aberrant or mutated proteins after protein translation 17. Be able to name some factors and/or chemicals that are known to cause DNA mutations 18. Understand why and under which circumstances DNA mutations can lead to cancer Final Exam: Chapter 10 (last section): Viruses & Viral infection 1. Rehearse the basic characteristics of viruses. Are they living organisms? 2. Know how capsulated viruses are taken up by their host cells. 3. How are enveloped viruses taken up by cells? 4. What are bacteriophages? 5. Rehearse the basic characteristics of retroviruses, such as HIV. 6. Know names of prominent DNA- and RNA viruses. 7. Know the difference between lytic and lysogenic viral cycle. 8. What is a viral capsid made up from? Chapter 17: Plant kingdom: Fungi, Plants, and the Colonization of Land 1. Be able to define a plant (morphologically, regarding its energy household, reproduction) 2. Be able to name the shared characteristics of green algae and modern land plants and be able to explain these findings in the context of the evolutionary theory (common descent part of the theory) 3. Be able to recall the names of fossilized early land plant ancestors (hint: Rhynia, Cooksonia) and know their characteristic features 4. Be able to name the major phases, events and plant structures involved in sexual reproduction of the four major plant groups = bryophytes (e.g. mosses, liverworts), pteridophytes (e.g. ferns, horsetails), gymnosperms (e.g. conifers) and angiosperms (= flowering plants) 5. Which group of plants were the first vascular plants on land? Which form of vascularization (conducting vessels) did they have? 6. Be able to name the two major conducting vessels in land plants and their function 7. Be able to define and explain following terms: alternation of generations, sporophyte stage, gametophyte stage, archegonium, antheridium, gametes, capsule, rhizoids, sporangium, gametangium, prothallium, sori, gynecium, androecium, cone, pollen, seed, fruit, ovules, ovary, ovary wall 8. Know which of the plant generations of the four major plant groups is (regarding their chromosome complement) haploid and which one is diploid 9. Rehearse the structures of a typical seed, including seed leaf, embryo, endosperm, seed coat 10. Know the names and functions of the female reproductive parts of a flowering plant 11. Know the names and functions of the male reproductive parts of a flowering plant 12. What is the function and location of macrospore and microspore mother cells in a flowering plant 13. Which cell builds the embryo sac in flowering plants? 14. What is the function of the pollen tube cells and the generative cell in gymnosperm and angiosperm pollen grains? 9 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 15. Know which part of a flower head of an angiosperm plant becomes the later fruit after pollination 16. Understand the importance of nectar, flower scent, colors and shapes in the attraction of pollinating animals 17. Be able to explain the advantages of animal pollination over wind pollination and how it relates to the evolutionary success of angiosperms on planet Earth 18. What are secondary metabolites in plants? Be able to discuss known or hypothesized functions of secondary plant metabolites for plant reproduction and survival 19. Know some names of important secondary plant metabolites as they relate to human nutrition, life style habits and good health (hint: fruits, wine, tobacco, coffee, perfumes, aspirin, St. John’s wort) Chapter 18: Animal kingdom - The evolution of animal diversity 1. Be able to name the hall mark features and characteristics of an animal 2. Rehearse the early embryonic phases of an animal, and know the sequence of events of it 3. Be able to define and explain following terms: heterotrophic, zygote, morula stage, blastula stage, gastrula stage, tissues, organs 4. Know the names and prospective function of the three embryonic tissue layers = endoderm, ectoderm, mesoderm 5. Rehearse the idea of the evolution of animal life forms from a single-celled heterotrophic protist (= protozoan) 6. Rehearse the animal taxonomy and make yourself familiar with the hall mark features and characteristics (incl. body symmetry, tissues, presence of coelom, segmentation, type of skeleton, nerve fibers, brains, organs) of following 9 animal phyla: sponges (porifera) jelly fishes (cnidaria) flatworms (platyhelminthes) roundworms (nematode) segmented animals (annelida) arthropods mollusks echinoderms vertebrates 7. Know the difference between digestive cavity and digestive system, Which animal phyla have which? 8. Understand the term “coelom” and its importance to animal evolution. What is the biological function of a coelom in modern animals? How is a pseudo-coelom different from a ‘real’ coelom? Which animal phylum has a pseudo-coelom? 9. Know the names of the three body parts of an insect and their biological function 10. Understand why slow, less mobile animals tend to be hermaphrodites 11. Know the general function and major differences of endo- and exoskeletons. Which animal phyla have an exoskeleton? Which ones have an endoskeleton? 12. Of which major biological molecule is the exoskeleton of animals made up from? Is it made up from live cells? 13. Of which major biological molecule is a bony endoskeleton of animals made up from? Is it made up from live cells? 14. Know the difference between molting and metamorphosis. Know animal phyla and representatives which perform them. 10 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 15. Rehearse the respiratory organs in insects, clams, land snails and land mammals 16. Know the unique body characteristics of a vertebrate animal 17. Be able to define and explain following terms: notochord, vertebrae, vertebral column, gill pouches, gill arches, gill slits, post-anal tail, jaw bones, skull, backbone 18. Rehearse the vertebrate animal evolution considering lancelets, placoderm fishes, ostracoderm fishes, cartilaginous fishes, bony fishes, amphibians, reptiles, marsupial and eutherian mammals 19. Be able to coincide major animal transitions with major geological and/or cosmic events on planet Earth, e.g. fish – amphibian transition, amphibian – reptile transition 20. Know names of prominent transition animals, which indicate the evolutionary transition from: fishes to amphibians; reptiles to birds, reptiles to mammals; 21. Be able to name the major adaptations of amphibians and reptiles to their unique environments 22. Be able to define and explain following terms: lateral line system, amphibian skin, scales, amniotic egg, external fertilization, internal fertilization, ectothermal 23. Be able to name the advantages of internal fertilization (performed by reptiles and mammals) over external fertilization (fishes and amphibians) 24. Who the heck was Archeopterix? 25. Know the differences of the embryonic development between reptiles, marsupials and mammals. How are the embryos nourished in these three different animal groups and where do they develop? Which role does the monotreme animal Platypus play in this context? 26. Know the difference between deuterostome and protostome animals. Be able to give the names of some prominent members in each group. 27. Rehearse the prominent primate features and know names of existing primate life forms 28. Know the difference between prosimians and anthropoids 29. Rehearse the milestone fossils of very early hominid evolution and know the continent of its origin (hints: Australopithecines, “Lucy”, Sahelanthropus) 30. Who was Homo habilis? Was he/she a toolmaker? 31. Know the name of the first hominid who evidently walked out of Africa. Was he/she upright walking/bipedal? 32. Rehearse the history of the extinct Homo sapiens species, H. sapiens neanderthalensis. When did they become extinct and where did they hang out last? 33. Chapter 13: Evolutionary Theory: How species and populations evolve 1. Be sure you remember the names of the major contributors to the development of the modern evolutionary theory (classical and synthetic), including Ch. Darwin, R. Wallace, T. Dobzansky, E. Mayr 2. Know the four basic statements and core ideas of the evolutionary theory as introduced by Darwin in 1859. 3. Know which further ideas and statements have been added to the theory in the 1940s by E. Mayr and T. Dobzshansky in the so-called “synthetic theory” 4. Understand and be able to interpret the phrase “survival of the fittest” in the context of the evolutionary theory; what does “fit” mean in a Darwinian sense? 5. What is meant in the evolutionary theory by the term “speciation”? 6. How is a species defined according to the modern evolutionary theory? 11 MIRA COSTA COLLEGE Life Sciences Department General Biology Lecture (BIO101); Instructor: Elmar Schmid, Ph.D. 7. Know examples of factors and events which can lead to speciation 8. Know the difference between allopatric and sympatric speciation. Know one or two (textbook) examples for each of these two. 9. Rehearse the meaning and examples of prezygotic as well as postzygotic reproductive barriers. How do and can they contribute to speciation? 10. Rehearse examples of important geological, cosmic and tectonic events on planet Earth which are considered to may have contributed to species separation, speciation or extinction (Key words: Pangaea super continent, Galapagos island, Hawaiian islands, Alvarez hypothesis, Madagaska, rift valley) 11. Understand the impact of continental drift and plate tectonics to the evolution of life on planet earth 12. Understand the term “selective pressure” in the context of adaptation as part of the evolutionary theory 13. Understand the term “artificial selection” and how this relates to the rise of the new phenotypes and species 14. Understand why and how reproductive isolation can trigger speciation 15. Know the difference between microevolution and macroevolution 16. Rehearse the outcomes of different selective pressures put upon a population and know the names of the different forms of selection. What is the difference between diversifying and directional selection? 17. Know examples of human activities which can lead to reproductive isolation of species 12