BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Katze, Michael G.
Professor of Microbiology
Associate Director, Washington National Primate
Research Center
eRA COMMONS USER NAME (credential, e.g., agency login)
MKATZE
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Boston University, Boston, Mass.
Hahnemann University, Philadelphia, Pa.
University of Uppsala, Uppsala, Sweden
B.A.
Ph.D.
Post-doc
1971
1980
1980–1982
Biology
Microbiology
Virology
A. Personal Statement
I have over 35 years of experience as a virologist and am a leader in applying systems biology approaches to
the study of virus-host interactions and the innate immune response. I am an author of over 300 papers and
reviews, the majority of which are related to the use of high-throughput and computational approaches to study
virus-host interactions. My group also has a long history of developing genomic resources for nonhuman
primate, ferret, and Syrian hamster models of human virus infection. I have considerable administrative
experience through my roles of Associate Director of Molecular Sciences at the Washington National Primate
Research Center (WaNPRC), the Head of the WaNPRC Division of Nonhuman Primate Systems Biology, and
as the Principal Investigator of a laboratory of over 35 members. As the PI on this R24 proposal, I will have
ultimate responsibility for all scientific and administrative aspects of the project and will use my scientific
background and expertise in the areas of virology, systems biology, and nonhuman primate models to provide
advice on scientific design and data interpretation.
B. Positions and Honors
Positions
1972–1973
1974–1976
1982–1984
1984–1986
1987–1991
1987–
1991–1995
1995–
1996–
1996–1999
2003–
Honors
1971
1980–1982
1998
1998
1999
2006
2006
2014
2015
Research Assistant, Wistar Institute, Philadelphia, PA
Research Assistant, University of Pennsylvania, Department of Microbiology, Philadelphia, PA
Research Associate, Sloan-Kettering Institute, New York, NY
Assistant Member, Sloan-Kettering Institute, New York, NY
Assistant Professor, Department of Microbiology, University of Washington, Seattle
Core Staff Scientist, Washington National Primate Research Center, Seattle
Associate Professor, Department of Microbiology, University of Washington, Seattle
Professor, Department of Microbiology, University of Washington, Seattle
Associate Director, Washington National Primate Research Center, Seattle
Member, Experimental Virology Study Section (NIH)
Adjunct Professor, Department of Bioengineering, University of Washington, Seattle
Boston University magna cum laude, Phi Beta Kappa
Long-term Postdoctoral Fellowship, European Molecular Biology Organization
Faculty Award for Undergraduate Research Mentoring
Travel Award, ISICR International Meeting in Jerusalem
Milstein Award, ISICR International Meeting in Paris
Dozor Scholar Award, Israeli Microbiology Society
Alumni Fellow Award, Drexel University (Hahnemann University) College of Medicine
Drexel University Graduate Citation, Mid-Career and Senior Graduates Award
Elected to Fellowship in the American Academy of Microbiology
C. Recent Peer-Reviewed Publications (From over 300 papers and reviews)
1.
Josset, L., N. Tchitchek, L.E. Gralinski, M.T. Ferris, A.J. Eisfeld, R. Green, M.J. Thomas, J. Tisoncik-Go,
G.P. Schroth, Y. Kawaoka, F. Pardo-Manuel de Villena, R.S. Baric, M.T. Heise, X. Peng, and M.G. Katze.
2014. Annotation of long non-coding RNAs expressed in Collaborative Cross founder mice in response to
respiratory virus infection reveals a new class of interferon-stimulated transcripts. RNA Biol. 11:875-890.
2.
Josset, L., H. Zeng, S.M. Kelly, T.M. Tumpey, and M.G. Katze. 2014. Transcriptomic characterization of
the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate
between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options.
mBio. 5(1):e01102-13. PMCID:PMC3950506
3.
Menachery, V.D., B.L. Yount, L. Josset, L.E. Gralinski, T. Scobey, S. Agnihothram, M.G. Katze, and R.S.
Baric. 2014. Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking
2-O-methyltransferase activity. J. Virol. 88:4251-4264. PMCID:PMC4030454
4.
Morrison, J., L. Josset, N. Tchitchek, J. Chang, J.A. Belser, D.E. Swayne, M.J. Pantin-Jackwood, T.M.
Tumpey, and M.G. Katze. 2014. H7N9 and other pathogenic avian influenza viruses elicit a threepronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal
outcome in mice. J. Virol. 88:10556-10568. PMCID:PMC4178843
5.
Peng, X. J. Alfoldi, K. Gori, A.J. Eisfeld, S.R. Tyler, J. Tisoncik-Go, D. Brawand, L. Law, N. Skunca, M.
Hatta, D.J. Gasper, S.M. Kelly, J. Chang, M. Thomas, J. Johnson, A.M. Berlin, M. Lara, P. Russell, R.
Swofford, J. Turner-Maier, S. Young, T. Hourlier, B. Aken, S. Searle, X. Sun, Y. Yi, M. Suresh, T.M.
Tumpey, A. Siepel, S.M. Wisely, C. Dessimoz, Y. Kawaoka, B.W. Birren, K. Lindblad-Toh, F. Di Palma,
J.F. Engelhardt, R.E. Palermo, and M.G. Katze. 2014. The draft genome sequence of the ferret (Mustela
putorius furo) facilitates study of human respiratory disease. Nature Biotechnol. 32:1250-1255. PMCID:
PMC4262547
6.
Peng, X., L. Pipes, H. Xiong, R.R. Green, D.C. Jones, W.L. Ruzzo, G.P. Schroth, C.E. Mason, R.E.
Palermo, and M.G. Katze. 2014. Assessment and improvement of Indian-origin rhesus macaque and
Mauritian-origin cynomolgus macaque genome annotations using deep transcriptome sequencing data. J.
Med Primatol. 43:317-328. PMCID: PMC4176519
7.
Peng, X, P. Sova, R.R. Green, M.J. Thomas, M.J. Korth, S. Proll, Z. Peng, J. Xu, Y. Cheng, K. Yi, L.
Chen, J. Wang, R.E. Palermo, and M.G. Katze. 2014. Deep sequencing of HIV infected cells: insights
into nascent transcription and host-directed therapy. J. Virol. 88:8768-8782. PMCID: PMC4136300
8.
Peng, X., J. Thierry-Mieg, D. Thierry-Mieg, A. Nishida, L. Pipes, M. Bozinoski, M.J. Thomas, S. Kelly, J.M.
Weiss, M. Raveendran, D. Muzny, R.A. Gibbs, J. Rogers, G.P. Schroth, M.G. Katze, and C.E. Mason.
2014. Tissue-specific transcriptome sequencing analysis expands the non-human primate reference
transcriptome resource (NHPRTR). Nucleic Acids Res. 43(Database issue):D737-42.
9.
Rasmussen, A.L., A. Okumura, M.T. Ferris, R. Green, F. Feldmann, S.M. Kelly, D.P. Scott, D. Safronetz,
E. Haddock, R. LaCasse, M.J. Thomas, P. Sova, V.S. Carter, D.R. Miller, G.D. Shaw, M.J. Korth, M.T.
Heise, R.S Baric, F. Pard-Manuel de Villena, H. Feldmann, and M.G. Katze. 2014. Host genetic diversity
enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 346:987-981. PMCID:
PMC4241145
10. Rasmussen, A.L., N. Tchitchek, D. Safronetz, V.S. Carter, C.M. Williams, E. Haddock, M.J. Korth, H.
Feldmann, and M.G. Katze. 2014. Delayed inflammatory and cell death responses are associated with
reduced pathogenicity in Lujo virus-infected cynomolgus macaques. J. Virol. 89:2943-2952.
PMCID:PMC4325716
11. Selinger, C., N. Strbo, L. Gonzalez, L. Aicher, J.M. Weiss, G.L. Law, R.E. Palermo, M. Vaccari, G.
Franchini, E.R. Podack, and M.G. Katze. 2014. Multiple low-dose challenges in a rhesus macaque AIDS
vaccine trial result in an evolving host response that affects protective outcome. Clinical Vaccine
Immunol. 15:1161.
12. Selinger, C. J. Tisoncik-Go, V.D. Menachery, S. Agnihothram, G.L. Law, J. Chang, S.M. Kelly, P. Sova,
R.S. Baric, and M.G. Katze. 2014. Cytokine systems approach demonstrates differences in innate and
pro-inflammatory host responses between genetically distinct MERS-CoV isolates. BMC Genomics.
15:1161.
13. Tchitchek, N., D. Safronetz, A.L. Rasmussen, C. Martens, K. Virtaneva, S.F. Porcella, H. Feldmann, H.
Ebihara, and M.G. Katze. 2014. Sequencing, annotation and analysis of the Syrian hamster
(Mesocricetus auratus) transcriptome. PLoS ONE. 9(11):e112617. PMCID: PMC4232415
14. Xiong, H., J. Morrison, M.T. Ferris, L.E. Gralinski, A.C. Whitmore, R. Green, M.J. Thomas, J. Tisoncik-Go,
G.P. Schroth, F. Pardo-Manuel de Villena, R.S. Baric, M.T. Heise, X. Peng, and M.G. Katze. 2014.
Genomic profiling of Collaborative Cross founder mice infected with respiratory viruses reveals novel
transcripts and infection-related strain-specific gene and isoform expression. G3: Genes, Genomes,
Genetics. 4:1429-1444. PMCID: PMC4132174
15. Barrenas, F., R. Green, M. Thomas, G.L. Law, S. Proll, F. Engelmann, I. Messaoudi, A. Marzi, H.
Feldmann, and M.G. Katze. 2015. Next generation sequencing reveals a controlled immune response to
Zaire Ebola virus challenge in cynomolgus macaques immunized with VSVG/EBOVgp. Clinical Vaccine
Immunol. 22:354-356. PMCID:PMC4340895
D. Research Support
Ongoing Research Support
R24 OD011172 Katze (PI) 09/01/2011 – 06/30/2015
OD — Development of Nonhuman Primate Reference Transcriptome Resources
This project uses new sequencing technologies to generate information about the structure of nonhuman
primate genomes and the diversity of transcripts that these genomes express. This information will have a wide
variety of uses, including helping to understand the role of these transcripts in human diseases such as AIDS,
the identification of new drug targets, or the design of new vaccine strategies. Role: Principal Investigator
HHSN272201300010C Katze (PI) 07/1/2013 – 06/30/2018
NIAID — Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and
Development
The core provides high-throughput transcriptomic measurements for nonhuman primate samples from animals
enrolled in priority protocols conducted by the Simian Vaccine Evaluation Unit (SVEU) and for samples from
other investigator-initiated studies as selected by the by the DAIDS Contract Officer Representative. The core
uses a LabKey laboratory information management system as a key component for tracking samples,
organizing results, reporting study, and managerial project monitoring. Role: Principal Investigator
P51 OD010425 Baillie (PI) 05/01/2012 – 04/30/2017
OD — Washington National Primate Research Center (Core Grant)
“Division of Nonhuman Primate Systems Biology” (Katze)
This is the core grant of the Washington National Primate Research Center. The Division of Nonhuman
Primate Systems Biology functions as a national resource for the development of nonhuman primate genomic
and proteomic resources and for the incorporation of genomics and proteomics into nonhuman primate
research. The Division includes a High-Throughput Molecular Profiling Core and a Statistical Analysis and
Computational Modeling Core. Role: Associate Director, Core Staff Scientist, and Head of Division of
Nonhuman Primate Systems Biology.
U19 AI109761 Lipkin (PI) 03/01/2014 – 02/28/2019
NIAID — Center for Research in Diagnostics and Discovery
“Project 2: Systems Biology Approaches to Molecular Diagnostics and Antiviral Drug Targeting” (Katze)
The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex
platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that
influence susceptibility of disease and predict effectiveness of drugs and vaccines. Project 2 uses highthroughput transcriptional profiling and novel non-linear geometric and machine learning methods to define
genome-wide gene-activity biomeasures diagnostic of severe disease, prognostic indicators of disease
outcome, and host therapeutic targets for inducing antiviral effects and/or attenuating disease severity. Role:
Project 2 Leader
R24 OD010445 Silvestri (PI) 05/01/2013 – 03/31/2017
OD — Transcriptome Resources for Comparative Primate Models of Lentivirus Infection
The goal of this project is to generate whole-transcriptome reference databases for several immune cell types
at baseline and during infection with HIV or SIV. An emphasis is placed on comparative models of pathogenic
and non-pathogenic infections. The project takes advantage of the vast amount of transcriptome data that can
be obtained through next-generation sequencing and leverages the complementary expertise of Dr. Katze in
RNA sequencing, systems biology, and bioinformatics and of Dr. Silvestri in AIDS research. Role: CoInvestigator
HHSN272201400005C Treanor (PI)
04/01/2014 – 03/31/2021
NIAID Centers of Excellence for Influenza Research and Surveillance
This Project will provide new knowledge regarding the innate immune response to influenza virus infection and
vaccination that can be used to develop more effective vaccines. In addition, this Project uses novel
computational methods that make use of genomic profiles to identify small molecules and FDA-approved drugs
that can be repurposed as antiviral therapies. Because many of these compounds have already been
evaluated in human subjects, this strategy is likely to significantly reduce the time needed to translate research
findings into clinical studies. Dr. Katze leads the Systems Biology of Innate Immunity and Vaccination Project
and the NYICE-CRIPS Cross-CEIRS project titled Determining Early Genomics Signatures from Ferret
Infection Models. Role: Co-Investigator
NSF 15-006 Katze (PI) 12/01/2014 – 11/31/2015
National Science Foundation — In vitro and in vivo evaluation of CANDO predictions for Ebola virus
therapeutics
This project evaluates drugs and small molecules identified by a novel computational screening approach for
their antiviral activity using an in vitro assay and a first-of-its-kind mouse model of Ebola virus disease. Many of
these candidates are drugs already approved by the Food and Drug Administration (FDA) for other indications.
Their repurposing as anti-Ebola virus therapeutics could therefore help to stem the current outbreak as well as
be used to treat new cases of Ebola virus infection that may occur in the United States or elsewhere. Role:
Principal Investigator