1
VICTOR CHI-MIN YANG
CURRICULUM VITAE
ADDRESS
College of Pharmacy
The University of Michigan
Ann Arbor, Michigan 48109-1065
TEL: (734) 764-4273
FAX: (734) 763-9772
E-mail: vcyang@umich.edu
CITIZENSHIP
US Citizen
EDUCATION
1978-1983
Ph.D., Biochemistry and Biophysics
Brown University (Providence, Rhode Island)
Thesis: “Properties of CDP-diglyceride, a Metabolic Intermediate in Phospholipid
Biosynthesis, and of Ara-CDP-diglyceride, a Potent Anticancer Drug”.
Advisor: Dr. Joseph M. Steim.
1975-1977
M.S., Biochemistry
Texas A&M University (Commerce, Texas)
Thesis: "Polymerization Study of Microtubular Protein and a Unique Isolation of
Tubulin Containing Ring Structures".
Advisor: Dr. Janice S. Barton.
1968-1972
B.S., Chemistry
TamKang University (Taipei, Taiwan).
PROFESSIONAL EXPERIENCE
2011-present Assistant to the President, Dean of the School of Pharmacy
Tianjin Medical University, Tianjin, China.
（天津医科大学校长助理，药学院院长）
2000-present Albert B. Prescott Professor of Pharmaceutical Sciences
College of Pharmacy, University of Michigan.
2005-present Cheung Kong Scholar (appointed by the Ministry of Education of China)
School of Chemical Engineering, Tianjin University, Tianjin, China
1997-present Professor of Pharmaceutics
College of Pharmacy, University of Michigan.
1995-present Affiliated Faculty
Department of Biomedical Engineering, University of Michigan.
1991-1996
Associate Professor of Pharmaceutics
College of Pharmacy, University of Michigan.
1986-1990
Assistant Professor of Pharmaceutics
College of Pharmacy, University of Michigan.
1983-1985
Postdoctoral Research Associate
Department of Chemical Engineering, M.I.T. (Advisor: Dr. Robert Langer).
1984-1985
Co-Lecturer
“Pharmacoengineering”; Department of Chemical Engineering, M.I.T.
1978-1982
Teaching/Research Assistant
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Chemistry Department, Brown University.
1975-1977
Research Assistant
Chemistry Department, Texas A&M, Commerce.
AWARDS/HONORS
2012
Student Appreciation Award, College of Pharmacy, University of Michigan.
2011
Chinese National 1000 Talents Program, China.（中国国家千人计划获得者）
2011
Tianjin 1000 Talents Program, Tianjin, China.（天津市千人计划获得者）
2009-2014
Participating Professor, World Class University Program (WCU), Department
of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University,
Seoul, Korea. （韩国首尔大学世界级大学特聘教授）
2008
Kenneth E. Avis Distinguished Visiting Professorship in Pharmaceutical
Sciences, Department of Pharmaceutical Sciences, College of Pharmacy, The
University of Tennessee Health Science Center, Memphis, TN.
2008
Teaching Excellence Award, College of Pharmacy, University of Michigan, Ann
Arbor, MI.
2008-present Honorable Director, Tianjin Key Laboratory for Modern Drug Delivery & High
Efficiency, Tianjin, China.
2007
Keynote Speaker, Korea CRS Symposium, Busan, Korea, August 21, 2007.
2007
Keynote Speaker, 3rd WACBE Symposium, Bangkok, Thailand, July 11, 2007.
2005-present Cheung Kong Scholar，China（中国教育部长江学者讲座教授）
2007-2012
Study Section Member, National Natural Science Foundation of China (NSFC)
2006
Hartwell Individual Biomedical Research Award.
2006-
Advisory Board, International Symposium on Recent Advances in Drug Delivery
Systems.
2005-
Advisory Council, World Association for Chinese Biomedical Engineers
(WACBE).
2004-2010
Taiwan National Advisory Board on Nano-medicine Research, National Health
Research Institute (NHRI), Taiwan. （台湾国家卫生院奈米所顾问）.
2006
Keynote Speaker, The 282th Xiang Shang Scientific Meeting (香山科学会议) in
Xiang Shan, China, on August 28-31, 2006.
2003
American Association of Pharmaceutical Scientists (AAPS) Research
Achievement Award in Biotechnology.
2003
American Association of College of Pharmacy (AACP) Paul Dawson
Biotechnology Award.
2003
Honored Guest Professor, Chinese Academy of Medicine and Union Medical
University, Beijing, China.
2002
Who’s Who in Engineering Education (WWEE).
2001
University Honored Guest Professor, Tianjin University, Tianjin, China.
2001
Visiting Scholar (09/01/01-11/30/01) Department of Chemical Engineering,
Massachusetts Institute of Technology, Cambridge, MA (Prof. Robert Langer).
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2001
Visiting Fellow (06/01/01-07/31/01) Selected by the Japan Society for the
Promotion of Sciences (JSPS) and the US National Science Foundation (NSF).
2001
Visiting Professor (03/12/01-03/16/01) Tokyo Women’s Medical University,
Tokyo, Japan.
2001
Fellow, American Institute for Medical and Biological Engineering (AIMBE).
2001-2005
Regular Member (07/01/01-06/31/05) NIH S&B (Surgery and Bioengineering) and
BTSS (Bioengineering Technology and Surgical Science) Study Section.
2000-present Albert B. Prescott Endowed Chair Professorship, College of Pharmacy, The
University of Michigan.
1993-present Regular Member, NIH Heart, Lung and Blood Study Section for reviewing SBIR
grants.
1999-2002
Board of Governors, Controlled Release Society (CRS).
1999
Tamkang University Chair Lectureship given by Tamkang University, Taipei,
Taiwan.
1999
Honorary Member, Society of Biomaterials and CRS in Taiwan.
1998
Visiting Scholar, National Science Council and National Tsing Hua University in
Taiwan.
1998
Keynote Speaker, Society of Biomaterials and CRS in Taiwan.
1997
Outstanding Alumni Lectureship given by Tamkang University, Taipei, Taiwan.
1997
Visiting Scholar, National Science Council (NSC) and National Defense Medical
Center (NDMC) in Taiwan.
1995
Fellow, American Association of Pharmaceutical Scientists (AAPS).
1995
Keynote Speaker, Chinese National Pharmaceutics Congress, Nanjing, China,
November.
1994
American Men and Women of Science
1994
Who's Who among Asian Americans
1993
Marquis Who's Who in Science and Engineering
1990
Arthur K. DooLittle Award, American Chemical Society (ACS) Polymeric
Materials Science and Technology (PMSE) Division.
1989
Most Outstanding Manuscript, American Association of Medical Instrumentation
(AAMI).
1982-1985
Member, New York Academy of Science.
PROFESSIONAL ORGANIZATIONS
2004-present Member of Biomaterial Society (BMS).
1993-6, 2000- Member of the American Association of Colleges of Pharmacy (AACP).
1986-present Member of the American Chemical Society (ACS).
1986-1993
Member of Michigan Technology Council (Biomedical/Biotechnology Committee)
1987-2005
Member of the American Society of Artificial and Internal Organs (ASAIO).
1987-2007
Member of the American Association for the Advancement of Science (AAAS).
1987-2006
Member of the Biomedical Engineering Society (BME).
1987-present Member of the American Association of Pharmaceutical Scientists (AAPS).
1989-1991
Member of the IEEE Engineering in Medicine and Biology Society (IEEE).
1991-1992
Member of the American Association for Clinical Chemistry (AACC).
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EDITORIAL BOARD
1999-present
1997-2000
1994-2000
1988-2000
AAPS Journal (Electronic Journal of AAPS)
Journal of Applied Biochemistry and Biotechnology.
ASAIO (American Society for Artificial Internal Organs) Journal.
BioTechniques.
COMMITTEE SERVICE
2004
2001-2005
Chair, AACP Paul Dawson Biotechnology Award Committee
NIH Surgery and Bioengineering Study Section.
2000-present Advisory Committee, Office of Technology Transfer and Corporate Research in
Medical School and the Technology Management Office of the University of
Michigan.
2000
1999-2002
1999-2002
1993-present
1992-present
1996-1998
1995-1996
1994-1996
1993-1994
1988-1993
Chair, Faculty Search Committee, College of Pharmacy, University of Michigan.
Board of Governors, Controlled Release Society (CRS).
Executive Committee, College of Pharmacy, University of Michigan.
NIH Heart, Lung and Blood Institute Study Section Committee for SBIR Grants.
Biotec Committee, American Association of Pharmaceutical Scientists.
Program Committee, Biomaterials Society.
Global Network Committee, Controlled Release Society (CRS).
Program Committee, American Society for Artificial Internal Organs (ASAIO).
Committee of Governance, Controlled Release Society (CRS).
NIH Heart, Lung and Blood Institute ad hoc Study Section for R01 Grants.
SYMPOSIUM ORGANIZED
1998
Workshop on “Monitoring and Applications of Anticoagulant and Thrombolytic
Drugs” at the Controlled Release Society (CRS) Annual Meeting in Las Vegas, NV
on June 25-26, 1998.
1990
The 200th ACS International Symposium on “Polymers for Cosmetic and
Pharmaceutical Applications”, Washington DC, 1990.
2006
Workshop on “Strategies for Improving the Therapeutic Activities of Macromolecular Drugs.” The 282th Xiang Shang Scientific Meeting (香山科学会议) in
Xiang Shan, China, on August 28-31, 2006.
2006
“International Forum on Green Chemical Science & Engineering and Process
Systems Engineering”, Tianjin, China, October 8-10, 2006.
2009
“International Symposium on Crystal Engineering & Drug Delivery System, Tianjin,
China, September 6-8, 2009.
RESEARCH INTERESTS
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MR Imaging and Transduction Therapy for Cancer Treatment.
Novel Targeted and Pro-drug Delivery Systems.
Brain Drug Delivery for Treatment of Parkinson and Alzheimer Diseases.
Site-Selective Thrombolysis.
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Anticoagulant, Antithrombotic, and Thrombolytic Agents
Non-Toxic Heparin Antagonists.
Bio-Sensors; Blood Diagnostic Assays.
Extracorporeal Detoxification System for Treatment of Autoimmune Diseases.
Polypeptide Carriers; pH-Sensitive Hydrogels for Light-Regulated Drug Delivery.
RESEARCH GRANTS
Received
1987
The University of Michigan Rackham Faculty Grant (PI; $10,000)
"A Protamine Filter for Extracorporeal Heparin Removal"
1987
Research Grant from the Office of Vice President for Research at the University of
Michigan (PI; $5,000)
"A Protamine Filter for Extracorporeal Heparin Removal"
1987
The Upjohn Research Endowment Research Grant (PI; $15,000).
"A Protamine Filter for Extracorporeal Heparin Removal"
1987-1992
"FIRST" Award, NIH Heart, Lung and Blood Institute (PI; $539,000).
"An Immobilized Protamine System for Extracorporeal Heparin Removal",
Priority Score: 147; Percentile: 17.3%.
1988-1991
Biomedical Engineering Research Grant, The Whitaker Foundation (PI; $187,500)
"An Engineering Approach for Extracorporeal Blood Deheparinization"
1988-1989
The University of Michigan Cancer Research Institute (PI; $7,500)
"A New Controlled Drug Delivery System"
1988-1989
The University of Michigan Phoenix Memorial Laboratory (PI; $5,000)
"Phospholipid Derivatives: A Possible Means for Delivering Drugs"
1989-1990
U.M. Research Partnership Program (PI; $24,500)
"A Novel Controlled Drug Delivery System"
1990
U. M. Vice President for Research (Co-PI; $100,000)
"Computer-Aided Molecular Design". One-time capital equipment purchase.
1990-1992
Parental Drug Association (PI; $15,000)
"A Novel, Long-Acting Parental Drug Delivery System"
1991-1992
Pharmaceutical Manufacturers Association Foundation, Inc. (PI; $5,000)
"Immobilized Protamine for Extracorporeal Heparin Removal"
1991-1992
University of Michigan Rackham Predoctoral Fellowship (for Youyin Fu) ($22,750)
"Assessment of Blood Compatibility of the Protamine-Coated Membrane"
1992-1993
College of Pharmacy Upjohn Research Endowment Award (PI; $25,000)
"Development of a Bioactive Artificial Lung"
1993-1994
U.M .Rackham Predoctoral Fellowship (for Thomas J. Cook) ($24,000)
"Polypeptides as Biodegradable Carrier for Drug Delivery"
1993-1994
American Association of Pharmaceutical Scientists (AAPS) ($4,000)
Undergraduate Award in Pharmaceutical Analysis (for Peter Angus)
1993-1997
National Institute of Health, Heart, Lung and Blood Institute (PI; $1,090,650)
"A Protamine Filter for Extracorporeal Heparin Removal"
Priority Score: 141; Percentile: 6.9%
1994-1995
Medtronic HemoTec., Inc. (PI; $190,000)
"An Electrochemical Heparin Sensor"
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1993-1994
College of Pharmacy Vahlteich Research Award (PI; $25,000)
"An Enzymatic Approach for the Inhibition of HIV Infectivity"
1994-1999
Whitaker Foundation Graduate Fellowship (for Tanya Wang) ($150,000)
" A Bio-Feedback Heparin Removal System”
1995-1996
The Upjohn Research Endowment Award (PI; $25,000)
"A Triggered Local Release of Active Thrombolytic Agents"
1996-1997
Medtronic HemoTec Inc. (PI; $140,000)
“Electrochemical Sensors for Heparin and Protamine”
1996-1999
National Institute of Health, Heart, Lung and Blood Institute, R01 HL 55461(1-4)
(PI; $626,970)
"Triggered Local Release of Active Thrombolytic Agents"
Priority Score: 144; Percentile: 17.5%
1998-1999
AACP Merck Research Scholar Award (for Sheren Lin) ($7,000)
“Identification of Antigenic Determinant in Autism”
1998-1999
Medtronic HemoTec Inc. (PI; $200,000)
“Electrochemical Sensors for Heparin and Protamine”
1998-2001
National Institute of Health, Heart, Lung and Blood Institute (PI; $810,896)
“New Direction for Extracorporeal Heparin Removal”
Priority Score: 131; Percentile: 3.3%
1999-2000
National Institute of Health, STTR Phase I Grant (Co-PI; $100,000)
“Effective, Non-Toxic Antagonist to Heparin and Low Molecular Weight Heparin”
Priority Score: 165
1999-2001
National Sciences and Engineering Research Council of Canada (NSERC)
($38,200). Graduate Fellowship (for Yongtao Li)
2000-2004
National Institute of Health, Heart, Lung and Blood Institute, R01 HL 55461(5-8)
(PI; $1,118,663)
"Triggered and Local Release of Active Thrombolytic Agents".
Priority Score: 180; Percentile: 19.7%
2000-2001
Medtronic HemoTec Inc. (PI; $200,000)
“Electrochemical Sensors for Heparin and Protamine”.
National Institute of Health (R01 Grant) (Co-PI; $403,489)
"Pharmacology/Bioengineering of New Treatments of Immune Thrombocytopenia
Purpura" (PI: Joseph Balthasar, College of Pharmacy, SUNY Buffalo, NY).
Priority Score: 162; Percentile: 10.6%
2001-2005
2001-2002
Rackham Predoctoral Fellowship (for Yongtao Li) ($35,000)
"ATTEMPTS: A Heparin/Protamine-Based Delivery System for Enzyme Drugs"
2002-2003
National Institute of Health SBIR Phase II Grant (Co-PI; $243,326)
“Effective and Non-Toxic Antagonist to Heparin and LMWH” (PI: Liang, ISTN, Inc)
Priority Score: 193
2002-2003
College of Pharmacy Vahlteich Research Award (Co-PI; $40,000)
“A Novel Approach for the Treatment of Parkinson Disease” (PI: Liang)
2002-2003
College of Pharmacy Vahlteich Research Award (PI; $25,000)
Equipment Purchase Funds for TE2000 Fluorescence Microscope.
2003-2004
Medtronic HemoTec Inc. (PI; $60,000)
“Electrochemical Sensors for Heparin and Protamine”
2003-2005
American Health Assistance Foundation [AHAF] (PI; $100,000)
“Brain BDNF Delivery for Targeting Alzheimer’s Disease”
2004-2005
National Institute of Health (R43 DK67723 SBIR Phase I Project) (Co-PI; $36,646)
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Silica-Chitosan Nanocomposite for Treating Peptic Ulcer, (PI: YJ Park, ISTN, Inc.).
Priority Score: 220
2004-2005
Department of Defense (DOD) Breast Cancer Research (PI, $112,532)
“Novel Approach for Simultaneous Imagining and Protein Therapy
BreastCancer” Among 159 selected from a total of 1290 applications.
for
2004-2006
National Institute of Health (PA-03-058) (PI; $412,067)
“Brain Drug Delivery Using Parkinson as a Disease Model”
Priority Score: 151
2005-2009
National Institute of Health, Heart, Lung and Blood Institute, R01 HL 55461(9-11)
(PI; $1,607,086)
"Triggered Local Release of Active Thrombolytic Agents”
Priority Score: 147; Percentile: 6.4%
2005-2010
National Institute of Health (R01 CA114612) (PI; $1,613,135)
“PTD-Mediated Protein or Drug Delivery for Cancer Therapy”.
Priority Score: 160; Percentile: 14.4%
2006-2010
National Institute of Health (Co-PI, $322,250)
“Development of Esterase for the Treatment of Cocaine Overdose or Abuse”.
Priority Score: 122; Percentile: 1.0%
2006-2009
National Institute of Health (R44 HL59705) (PI, $636,924)
“Effective and Non-Toxic Antagonist to Heparin and LMWH”.
Priority Score: 148
2006-2007
Munn Idea Award (PI; $20,000)
Jerome and Mary Miller Fund for Cancer Research
University of Michigan Comprehensive Cancer Center
"Synchronized MRI and Drug Therapy for Brain Tumors”
Priority Score: 1.6
2007-2008
Predoctoral Fellowship for Beata Chertok ($44,000)
University of Michigan Rackham Graduate School
"Synchronized MRI and Drug Therapy for Brain Tumors”
2007-2010
Hartwell Foundation Individual Biomedical Research Award (PI; $300,000)
"Synchronized MRI and Drug Therapy for Pediatric Brain Tumors”
2007-2011
National Institute of Health (R01 HL 067347) (Co-PI; $380,000)
"Pharmacology and Bioengineering of New Treatments of Idiopathic Thrombocytopenia Purpura" (PI: Joseph Balthasar, SUNY Buffalo, NY).
Priority Score: 153; Percentile: 14.5%
2008-2010
National Institute of Health (R43 DK 081299) (Co-PI; $133,200)
“Innovative Formulation for Oral Insulin Delivery” (PI: Allan David, ISTN, Inc.)
Priority Score: 208
2008-2009
National Institute of Health (R43 CA 135969) (Co-PI; $41,300)
“RBC-Encapsulated Asparaginase for Enhanced Acute Lymphoblastic Leukemia
Therapy” (PI: Allan David, ISTN, Inc.)
Priority Score: 195
2009
MICHR/CTSA Pilot Grant (PI; $25,000)
“Non-Invasive Brain Delivery of GDNF for Treatment of Parkinson’s Disease.”
Priority Score: 28
2009-2011
National Institute of Health, National Institute of Neurological Disorders and Stroke
(R01 NS066945; ARRA Stimulus Grant) (PI; $750,000)
"MION for Synchronized MRI and Drug Therapy of Brain Tumors.”
Priority Score: 23; Percentile: 17%.
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2010-2014
National Institute of Health, National Institute of Arthritis and Musculoskeletal and
Skin Disease (Co-PI; $304,000)
“Use of Simvastatin to Retard Degenerative Disc Disease” (PI: Chia-Ying Lin,
Department of Neurosurgery, University of Michigan Medical School).
Priority Score: 29; Percentile: 16%.
2010
UMCCC Prostate Score Grant (PI; $50,000)
“Mr-Imaged, Clinically Enabled Pharmacological Treatment of Prostate Cancers.”
2011-2016
National Institute of Health (R01 CA114612) (PI; $1,250,000)
“PTD-Mediated Protein or Drug Delivery for Cancer Therapy”.
Priority Score: 18; Percentile: 6%.
Pending
2013-2017
National Institute of Health (R01 NS66945) (PI; $1,379,000)
“MION for Synchronized MRI and Drug Therapy of Brain Tumors”.
PUBLICATIONS
1.
Victor C. Yang, Joseph G Turcotte, and Joseph M Steim. Physical Properties of Arabinofuranosylcytosine Diphosphate Diacylglycerol, an Antitumor Liponucleotide. Biochimica et Biophysica Acta
689:375-384 (1982).
2.
Victor C. Yang, Robert J. Linhardt, Howard Bernstein, Charles L. Cooney, and Robert Langer.
Purification and Characterization of Heparinase from Flavobacterium Heparinum. Journal of
Biological Chemistry 260:1849-1857 (1985).
3.
Victor C. Yang, Joseph G. Turcotte, and Joseph M. Steim. Biophysical Properties of Cytidine
Diphosphate Diglyceride in Solution. Biochimica et Biophysica Acta 834:364-375 (1985).
4.
Victor C. Yang, Howard Bernstein, and Robert Langer. An Immobilized Enzyme Reactor for
Extracorporeal Deheparinization. In: New Aspects in Extracorporeal Detoxification pp. 22-25 (Ing.
H. Chmiel and E. Streicher, eds.), 3rd Tutzing Symposium on Chemical Engineering in Medicine,
Lake Starnberg, West Germany (1985).
5.
Victor C. Yang, and Robert Langer. A New and Rapid Method, the pH-Dependent Binding
Analysis, for Isoelectric Point Estimation. Analytical Biochemistry 147:148-155 (1985).
6.
Robert Langer, Howard Bernstein, Annette Larsen, Victor C. Yang, David Tapper, and Dennis
Lund. An Enzymatic Approach to Anticoagulation Control. American Society for Artificial Internal
Organs Journal 8:213-214 (1985).
7.
Victor C. Yang, Lori Morgan, Mary T. McCarthy, and Robert Langer. Isoelectric Points of
Polysaccharide-Degrading Enzymes in Flavobacterium Heparinum. Carbohydrate Research 143:
294-299 (1985).
8.
Victor C. Yang, Howard Bernstein, Charles L. Cooney, Jill Kadam, and Robert Langer. Removal of
the Anticoagulant Activities of the Low Molecular Weight Heparin Fractions and Fragments with
Flavobacterial Heparinase. Thrombosis Research 44:599-610 (1986).
9.
Howard Bernstein, Victor C. Yang, and Robert Langer. The Distribution of Heparinase Covalently
Immobilized to Agarose: Experimental and Theoretical Studies. Biotechnology and Bioengineering
30:197-207 (1987).
10.
Howard Bernstein, Victor C. Yang, and Robert Langer. Immobilized Heparinase: In Vitro Reactor
Model. Biotechnology and Bioengineering 30:239-250 (1987).
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11.
Victor C., Yang, Howard Bernstein, and Robert Langer. Large Scale Purification of Heparinase.
Biotechnology Progress 3:27-30 (1987).
12.
Victor C. Yang, and Robert Langer. A Simple and Economic Technique for pI Measurements.
BioTechniques 5:138-144 (1987).
13.
Howard Bernstein, Victor C. Yang, Charles L. Cooney, and Robert Langer. An Immobilized
Heparin Lyase System for Blood Deheparinization. Methods in Enzymology 137:515-529 (1987).
14.
Howard Bernstein, Victor C. Yang, Dennis Lund, Mohinder Randhawa, William Harmon, and
Robert Langer. Extracorporeal Enzymatic Heparin Removal: Use in a Sheep Dialysis Model.
Kidney International 32:452-463 (1987).
15.
Victor C. Yang, Howard Bernstein, and Robert Langer. The Development of an Immobilized
Heparinase Reactor.
In: Bioreactor Immobilized Enzymes and Cells: Fundamentals and
Applications, pp. 83-94 (Moo-Young, ed.), Elsevier, U.K. (1988).
16.
Victor C. Yang, Howard Bernstein, Charles L. Cooney, and Robert Langer. Large Scale
Preparation and Characterization of Mucopolysaccharase Contamination Free Heparinase. Applied
Biochemistry and Biotechnology 16:35-49 (1988).
17.
Victor C. Yang, Howard Bernstein, and Robert Langer. An Investigation of Heparinase
Immobilization. Applied Biochemistry and Biotechnology 16:129-143 (1988).
18.
Victor C. Yang, and Ching-Leou Teng. A Protein-Bound Polymeric Filter Device for Extracorporeal
Blood Deheparinization. Polymeric Materials Science and Engineering 58:116-119 (1988).
19.
Ching-Leou C. Teng, Jae-Seung Kim, Friedrich K. Port, Thomas W. Wakefield, Gerd O. Till, and
Victor C. Yang. A Protamine Filter for Extracorporeal Blood Heparin Removal. American Society
of Artificial and Internal Organs Transactions 34:743-746 (1988).
20.
Victor C. Yang, Howard Bernstein, and Robert Langer. Heparinase Immobilization: Optimization
and Characterization. In: Enzyme Engineering XI, Annals of the New York Academy of Science
542:515-520 (1989).
21.
Ching-Leou Teng, and Victor C. Yang. A Facile, Colorimetric Protamine Titration Method. Journal
of Laboratory and Clinical Medicine 43:498-504 (1989).
22.
Victor C. Yang, and Robert Langer. Strategy Development Regarding Large Scale Protein
Purification. Proceedings 2nd International Conference on Separation Science and Technology
(M.H.I Baird and S. Vijayan, eds.) pp. 515-522 (1989).
23.
Victor C. Yang. A Simple Method for Rapid and Precise Estimation of the Protamine Dose
Required for Clinical Heparin Reversal.
American Society for Artificial Internal Organs
Transactions 35:274-277 (1989).
24.
Victor C. Yang. Protamine Filter: A Novel Approach for the Control of Complications of Heparin
Therapy. Proceedings of the International Conference of the IEEE Engineering in Medicine and
Biology Society (Y. Kim and F.A. Spelman, eds.), vol. 11, pp. 1067-1068 (1989).
25.
Jae-Seung Kim, Christopher Vincent, Ching-Leou C. Teng, Thomas W. Wakefield, and Victor C.
Yang. A Novel Approach to Anticoagulation Control. American Society for Artificial Internal Organs
Transactions 35:644-646 (1989).
26.
Victor C. Yang, and Alexander C.L. Tsuei. Phospholipid Derivatives: A Possible Means for
Controlled Delivery of Nucleoside Drugs. Proceedings of the 16th International Symposium on
Controlled Release of Bioactive Materials (R. Pearlman, and J.A. Miller, eds.) pp. 221-222 (1989).
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27.
Victor C. Yang, and Ching-Leou C. Teng. An Immobilized Protamine System for Removing
Heparin in Extracorporeal Blood Circulation. In: Biomimetic Polymers (C. Gebelein, ed.) pp.175190, Plenum Press, New York (1990).
28.
Alexander C.L. Tsuei, and Victor C. Yang, Ion-exchange Hollow Fibers. ACS Polymer Preprints
31:238-240 (1990).
29.
You-Yin Fu, Ching-Leou C. Teng, and Victor C. Yang. A Rapid and Precise Whole Blood
Protamine Titration. American Society of Artificial Internal Organs Transactions 36:660-663
(1990).
30.
Victor C. Yang, Ching-Leou C. Teng, and Jae-Seung Kim. A Filter for the Prevention of Both
Heparin and Protamine Induced Complications Associated with Extracorporeal Therapy.
Biomedical Instrumentation and Technology 24:433-439 (1990).
31.
Charles Gebelein, Tai Cheng and Victor C. Yang. Cosmetic, Pharmaceutical and Medical
Polymers: A Common Theme. Polymeric Materials Science and Engineering 63:401-405 (1990).
32.
Victor C. Yang, and Jae-Seung Kim. Biopolymer Coupled with Heparin Antidote for In Vivo
Heparin Removal. Polymeric Materials Science and Engineering 63:134-138 (1990).
33.
Alexander C.L. Tsuei, and Victor C. Yang. Preparation of DEAE-Hollow Fibers for High Flow
Liquid Chromatography. Biomaterials 11:734-737 (1990).
34.
Weiliam Chen, and Victor C. Yang. A Versatile, Non-Clotting and Non-Instrumental Based
Heparin Assay. Clinical Chemistry 37:832-837 (1991).
35.
Victor C. Yang, Friedrich K. Port, Ching-Leou C. Teng, Jae-Seung Kim, Gerd. O. Till, and Thomas
W. Wakefield. The Use of Immobilized Protamine in Removing Heparin and Preventing Protamine
Induced Complications During Extracorporeal Blood Circulation. Anesthesiology 75:288-297
(1991).
36.
Jae-Seung Kim, You-Yin Fu, and Victor C. Yang. The Development of Protamine-Coated Hollow
Fibers: In Vitro Characterization and In Vivo Testing. In: Cosmetic and Pharmaceutical
Applications of Polymers (C. Gebelein, T. Cheng, and V.C. Yang, eds.), pp. 347-370, Plenum
Press, New York (1991).
37.
Weiliam Chen, and Victor C. Yang. The Development of a Cellulosic Material Based Method for
Heparin Therapy Monitoring. In: Cosmetic and Pharmaceutical Applications of Polymers (C.
Gebelein, T. Cheng, and V.C. Yang, eds.), pp. 329-346, Plenum Press, New York (1991).
38.
Weiliam Chen, and Victor C. Yang. A Test Strip Method for Heparin Sensing: Aspects for Clinical
Laboratory Application. CHIMICAoggi 9 (Oct.):43-49 (1991).
39.
Victor C. Yang, You-Yin Fu, and Jae-Seung Kim. Protamine-Coated Cuprophan: A Potential NonThrombogenic Hemodialysis Membrane with Improved Blood Compatibility. American Society of
Artificial Internal Organs Transactions 37:229-232 (1991).
40.
Victor C. Yang, and Weiliam Chen. A Protamine-Mediated Heparin Sensing Device. American
Society of Artificial Internal Organs Transactions 37:292-294 (1991).
41.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang. Heparin-Responsive Electrochemical
Sensor: A Preliminary Study. Analytical Chemistry 64:694-697 (1992).
42.
Jae-Seung Kim, and Victor C. Yang. Protamine Immobilization and Heparin Adsorption on the
Protamine-Bound Cellulose Fiber Membrane. Biotechnology and Bioengineering 39:450-456
(1992).
43.
Victor C. Yang, Shu-Ching Ma, and Jae-Seung Kim. Biopolymers for Heparin Removal and
Monitoring. Polymeric Materials Science and Engineering 66:180-181 (1992).
11
44.
Victor C. Yang, and Shu-Ching Ma. A Protamine-Coated Device for the Control of Heparin
Anticoagulation. The International Journal of Artificial Organs 15:611-613 (1992).
45.
Shu-Ching Ma, and Victor C. Yang. Applications of Affinity Binding to the Development of Heparin
Removing and Sensing Devices. In: Molecular Interactions in Bioseparations (T.T. Ngo, ed.),
Plenum Press, New York, pp. 451-468 (1993).
46.
Shu-Ching Ma, Bin Fu, Mark E. Meyerhoff, and Victor C. Yang. Electrochemical Sensor for
Heparin: Further Characterization and Bioanalytical Applications. Analytical Chemistry 65:20782084 (1993).
47.
Jung Hoon Yun, Shu-Ching Ma, Bin Fu, Victor C. Yang, and Mark E. Meyerhoff. Direct
Potentiometric Membrane Electrode Measurements of Heparin Binding to Macromolecules.
Electroanalysis 5:719-724 (1993)
48.
Victor C. Yang, Shu-Ching Ma, and Mark E. Meyerhoff. Thinning Blood Safely. CHEMTECH
23:25-32 (1993).
49.
Victor C. Yang, Shu-Ching Ma, Dong Liu, Richard B. Brown, and Mark E. Meyerhoff. A Novel
Electrochemical Heparin Sensor. American Society of Artificial Internal Organs Journal 39:195-201
(1993).
50.
Victor C. Yang. A Sensor-Controlled, Polymer-Based, Bio-Feedback Heparin Removal System.
Proceedings of the POLYMED'93, pp. 79-86, Schotland Business Research Inc., Princeton, New
Jersey (1993).
51.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang. Polymer-Based Systems for Heparin
Removal and Monitoring. Polymer News 19:38-48 (1994).
52.
Victor C. Yang, You-Yin Fu, Ching-Leou C. Teng, Shu-Ching Ma, and Jacob N. Shanberge. A
Method for the Quantitation of Protamine in Plasma. Thrombosis Research 74:427-434 (1994).
53.
Jong Hoon Yun, Mark E. Meyerhoff, and Victor C. Yang. A Disposable Coated-Wire Heparin
Sensor. American Society of Artificial Internal Organs Journal 40:401-405 (1994).
54.
Bin Fu, Eric Bakker, Jong Hoon Yun, Victor C. Yang, and Mark E. Meyerhoff. Response
Mechanism of Polymer Membrane-Based Potentiometric Polyion Sensors. Analytical Chemistry
66:2250-2259 (1994).
55.
Jong Hoon Yun, Mark E. Meyerhoff, and Victor C. Yang, "Protamine Sensitive Polymer Membrane
Electrode: Characterization and Bioanalytical Applications." Analytical Biochemistry 224:212-220
(1995).
56.
Enju Wang, Mark E. Meyerhoff, and Victor C.Yang. Optical Sensing of Macromolecular Heparin
via Selective Co-extraction into Thin Polymer Films. Analytical Chemistry 67:522-527 (1995).
57.
Bin Fu, Eric Bakker, Jong Hoon Yun, Enju Wang, Victor C. Yang, and Mark E. Meyerhoff. Polymer
Membrane-Based Polyion Sensors: Development, Response Mechanism, and Bioanalytical
Applications. Electroanalysis 7:823-829 (1995).
58.
Bin Fu, Eric Bakker, Victor C. Yang, and Mark E. Meyerhoff. Extraction Thermodynamics of
Polyanions into Plasticized Polymer Membranes Doped with Lipophilic Ion-Exchangers: A
Potentiometric Study. Macromolecules 28:5834-5840 (1995).
59.
Mark E. Meyerhoff, Bin Fu, Shu-Ching Ma, Eric Bakker, Jong-Hoon Yun, Victor C. Yang, and
Joyce A. Wahr. Polyion Sensitive Membrane Electrodes: Improbable Devices Capable of
Monitoring Heparin Levels in Whole Blood. American Association of Clinical Chemists Blood
Gas/Electrolytes Division Newsletter 10:4-8 (1995).
12
60.
Youngro Byun, Jong Hoon Yun, In Suk Han, Youyin Fu, Jacob N. Shanberge, and Victor C. Yang.
A Protamine Filter for Extracorporeal Heparin Removal: Development, Blood Compatibility
Evaluation, and Future Direction. American Society of Artificial Internal Organs Journal 41:301-305
(1995).
61.
Jong Hoon Yun, Lai-Ming Lee, Joyce Wahr, Mark E. Meyerhoff, and Victor C. Yang. Clinical
Application of Disposable Heparin Sensors: Blood Heparin Measurements During Open Heart
Surgery. American Society of Artificial Internal Organs Journal 41:661-664 (1995).
62.
Mark E. Meyerhoff, Victor C. Yang, Joyce A. Wahr, Lai-Ming Lee, Jong Hoon Yun, Bin Fu, and
Eric Bakker. Potentiometric Polyion Sensors: A New Measurement Technology for Monitoring
Blood Heparin Levels During Open Heart Surgery. Clinical Chemistry 41:1355-1356 (1995).
63.
Xuan Guo, Victor C. Yang, and Mark E. Meyerhoff. Homogeneous Enzyme-Based Binding Assay
for Studying Glycosaminoglycan-Macromolecule Interactions. Analytical Biochemistry 235:153-160
(1996).
64.
Bin Fu, Jong Hoon Yun, Joyce Wahr, Mark E. Meyerhoff, and Victor C. Yang. Polyionic DrugSensitive Membrane Electrodes: Principles and Practice. Advanced Drug Delivery Reviews 21:215223 (1996).
65.
Joyce A. Wahr, Jong Hoon Yun, Victor C. Yang, Lai Ming Lee, Bin Fu, and Mark E Meyerhoff. A
New Method of Measuring Heparin Levels in Whole Blood by Protamine Titration Utilizing a
Heparin-Responsive Electrochemical Sensor. Journal of Cardiothoracic and Vascular Anesthesia
10:447-450 (1996).
66
Bin Fu, Mark E. Meyerhoff, Jong Hoon Yun, and Victor C. Yang. Polyion Sensitive Membrane
Electrodes: Principles and Biomedical Applications. Analytical Chemistry 68:168-175 (1996).
67.
In Suk Han, Narayanan Ramamurthy, Jong Hoon Yun, Ulrich Schaller, Mark E. Meyerhoff, and
Victor C. Yang. Selective Monitoring of Peptidase Activities with Synthetic Polypeptide Substrates
and Polyion-Sensitive Membrane Electrode Detection. FASEB Journal 10:1621-1626 (1996).
68.
Youngro Byun, Tanya Wang, Jae-Seung Kim, and Victor C. Yang. Optimization and Assessment
of the In Vivo Efficacy of a Heparin-Removing Bio-Reactor Using Mathematical Modeling. American
Society of Artificial Internal Organs Journal 42:782-787 (1996).
69.
Youngro Byun, Tanya Wang, and Victor C. Yang. A Protamine Bioreactor for Extracorporeal
Heparin Removal: Development, In Vitro Modeling, and In Vivo Testing. Journal of Biomedical
Engineering (Taiwan) 9:41-48 (1997).
70.
Jong Hoon Yun, Shu-Ching Ma, Bin Fu, In-Suk Han, Mark E. Meyerhoff, and Victor C. Yang. A
Novel Electrochemical Heparin Sensor: Principles and Practice. Journal of Biomedical Engineering
(Taiwan) 9:49-55 (1997).
71.
Ibrahim H. A. Badr, Narayanan Ramamurthy, Victor C. Yang, and Mark E. Meyerhoff.
Electrochemical Assay of Proteinase Inhibitors Using Polycation Sensitive Membrane Electrode.
Analytical Biochemistry 250:74-81, (1997).
72.
Thomas J. Cook, Gordon L. Amidon, and Victor C. Yang. Polypeptides for Controlled Release
Applications: Synthesis and Preliminary Characterization and Release Studies. International
Journal of Pharmaceutics 159:197-206 (1997).
73.
Tanya Wang, Youngro Byun, Yuehua Zhang, and Victor C. Yang. A Bio-Feedback Drug Removal
System. In: Advances in Polymeric Biomaterials Science (T. Akaike, T. Okano, M. Akashi, et al.,
Eds.) Kodansha Elsevier, Tokyo, Japan, pp. 489-501 (1997).
13
74.
Teresa M. Ambrose, Ibrahim H. A. Badr, Sheng Dai, Joan M. Esson, Narayanan Ramamurthy,
Victor C. Yang, and Mark E. Meyerhoff. Biomedical Application of Polyion Sensitive Membrane
Electrodes. EUROSENSORS XI 1:15-18, 1997.
75.
Narayanan Ramamurthy, Narayanan Baliga, Joyce A. Wahr, Ulrich Schaller, Victor C. Yang, and
Mark E. Meyerhoff. Improved Polycation-Sensitive Membrane Electrode for Monitoring Heparin
Levels in Whole Blood via Protamine Titration. Clinical Chemistry 44:606-613, (1998).
76.
Yuehua Zhang, Vijendra K. Singh, and Victor C. Yang. Poly-L-Lysine Amplification of Protamine
Immobilization and Heparin Adsorption. Journal of Biomedical Materials Research 42:182-187
(1998).
77.
Vijendra K. Singh, Sheren X. Lin, and Victor C. Yang. Serological Association of Measles Virus
and Human Herpevirus-6 with Brain Autoantibodies in Autism. Clinical Immunology and
Immunopathology 89:105-108 (1998).
78.
Yuehua Zhang, and Victor C. Yang. Novel Approach for Optimizing the Capacity and Efficacy of a
Protamine Filter for Clinical Extracorporeal Heparin Removal. ASAIO Journal 44:368-373 (1998).
79.
Youngro Byun, and Victor C. Yang. A Delivery System for Targeted Thrombolysis without the Risk
of Hemorrhage. ASAIO Journal 44:638-641 (1998).
80.
Victor C. Yang. Approaches for Triggered and Local Release of Active Thrombolytic Agents. In:
Proceedings of the 1st Symposium of Biomaterials and Controlled Release Society of Taiwan, pp.
116-141, Chi May Co. LTD., Taipei, Taiwan (1998).
81.
Sheng Dai, Joan M. Esson, Oliver Lutze, Narayanan Ramamurthy, Victor C. Yang, and Mark E.
Meyerhoff. Bioanalytical Applications of Polyion-Sensitive Electrodes. Journal of Pharmaceutical
and Biomedical Analysis 19:1-14 (1999).
82.
Narayanan Ramamurthy, Narayanan Baliga, Thomas W. Wakefield, Philip C. Andrews, Victor C.
Yang, and Mark E. Meyerhoff. Determination of Low Molecular Weight Heparins and Their Binding
to Protamine and a Protamine Analogue Using Polyion-Sensitive Membrane Electrodes. Analytical
Biochemistry 266:116-124 (1999).
83.
Peter Markland, Gordon L. Amidon, and Victor C. Yang. Modified Polypeptides Containing Benzylglutamic Acid as Drug Delivery Platforms. International Journal of Pharmaceutics 173:183192, (1999).
84.
Youngro Byun, Vijendra K. Singh, and Victor C. Yang, “Low Molecular Weight Protamine: A
Potential Non-Toxic Heparin Antagonist.” Thrombosis Research 94:53-61 (1999).
85.
Hong Wang, Hui Song, and Victor C. Yang. A Recombinant, Pro-Drug Type Approach for
Triggered Delivery of Streptokinase. Journal of Controlled Release 59:119-122 (1999).
86.
Jong Hoon Yun, Narayanan Ramamurthy, Mark E. Meyerhoff, and Victor C. Yang.
Electrochemical Sensors for Polyionic Macromolecules: Development and Applications in
Pharmaceutical Research. Pharmaceutical Science & Technology Today 2:102-110 (1999).
87.
Peter Markland, Gordon L. Amidon, and Victor C. Yang. A Novel pH-Responsive Polypeptide
Hydrogel: Synthesis, Characterization, and Preliminary Drug Release Studies. Journal of
Biomedical Materials Research 47:595-602 (1999).
88.
Junfeng Liang, Hui Song, Maureen Connell, Youngtao Li, Youngro Byun, and Victor C. Yang. The
Use of “ATTEMPTS” Approach for Delivery of Thrombolytic Drugs with Associated Bleeding Risks.
Proceeding of the Pharmaceutical Technology Conference Vol. 3, pp 14-30 (1999).
89.
Li-Chien Chang, Mark E. Meyerhoff, and Victor C. Yang. Electrochemical Assay of Plasminogen
Activators in Plasma Using Polyion Sensitive Membrane Electrode Detection. Analytical
Biochemistry 276:8-12 (1999).
14
90.
Jun-Feng Liang, and Victor C. Yang, “ATTEMPTS: A Novel Approach for Delivery of Enzyme
Drugs without Associated Toxic Effects.” Proceeding of the Global Chinese Symposium on
Biomaterials and Controlled Release, pp 39-51 (1999).
91.
That T. Ngo, and Victor C. Yang. Biosensors: An Overview. In: Biosensors and Applications (VC
Yang, TT Ngo, eds.), Kluwer Academics/Plenum Publishers, New York, pp ix-v (2000).
92.
Bin Fu, Mark E. Meyerhoff, and Victor C. Yang. Recent Development in Polymer MembraneBased Potentiometric Polyion Sensors. In: Biosensors and Applications (VC Yang, TT Ngo, eds.),
Kluwer Academics/Plenum Publishers, New York, pp 147-157 (2000).
93.
Junfeng Liang, Yongtao Li, and Victor C. Yang. A Novel Approach for Delivery of Enzyme Drugs:
Preliminary Demonstration of Feasibility and Utility in Vitro. International Journal of Pharmaceutics
202:11-21 (2000).
94.
Hui Song, Jun-Feng Liang, and Victor C. Yang. A Pro-drug Approach for Delivery of t-PA:
Construction of the Cationic t-PA Prodrug by Recombinant Method and Preliminary in Vitro
Evaluation of the Construct. ASAIO Journal 46:663-668 (2000).
95.
Youngro Byun, Li-Chien Chang, Lai-Ming Lee, In Suk Han, Vijendra K. Singh, and Victor C. Yang.
Low Molecular Weight Protamine: A Potent but Non-Toxic Antagonist to Heparin/LMWH. ASAIO
Journal 46:435-439 (2000).
96.
Jun-Feng Liang, Yong T. Li, and Victor C. Yang. The Potential Mechanism for the Effect of
Heparin on t-PA-Mediated Plasminogen Activation. Thrombosis Research 97:349-358 (2000).
97.
Jun-Feng Liang, Maureen E. Connell, Yong T. Li, and Victor C. Yang. Synthesis and
Characterization of Positively Charged t-PA as a Prodrug Using Heparin/Protamine Drug Delivery
System. AAPS PharmSci 2(1), article 7 (2000) (http://www.pharmsci.org).
98.
Jun-Feng Liang, Hui Song, Yong T. Li, and Victor C. Yang. A Novel Heparin/Protamine-Based
Pro-drug Type Delivery System for Protease Drugs. Journal of Pharmaceutical Sciences 89:664673 (2000).
99.
Jun-Feng Liang, Yong T. Li, and Victor C. Yang, “Biomedical Application of Immobilized Enzymes.”
Journal of Pharmaceutical Sciences 89:979-990 (2000).
100. Jun-Feng Liang, Yoon Jeong Park, Hui Song, Yong T. Li, and Victor C. Yang. Enzyme Drug
Delivery Using a Heparin/Protamine Delivery System. Biomaterials and Drug Delivery Systems
Toward New Millennium (Ki Dong Park, Ich Chan Kwon, Nobuhiko Yui, Seo Young Jeong, Kinam
Park, eds.), pp 49-61(2000).
101. Victor C. Yang. Overview of Drug Delivery Systems. Proceedings of the Symposium of New
Trend in Biotechnology in the New Millennium, Section I, pp. 1-56, Center for Biomedical
Engineering, Industrial Technology Research Institute, Hsinchu, Taiwan (2000).
102. Victor C. Yang. Approaches for Delivery of Enzyme Drugs. Proceedings of the Symposium of New
Trend in Biotechnology in the New Millennium, Section II, pp 1-42, Center for Biomedical
Engineering, Industrial Technology Research Institute, Hsinchu, Taiwan (2000).
103. Victor C. Yang. Recent Advances in Heparin Anticoagulation Control. Tamkang Chair Lecture
Series 129:1-33 (2001).
104. Victor C. Yang. Heparin and Protamine Biosensors: Principle and Biomedical Applications.
Tamkang Chair Lecture Series, 129:34-58 (2001).
105. Victor C. Yang, “ATTEMPTS: A Novel Approach for Delivery of Catalytic Enzyme Drugs without
Associated Toxic Effects.” Tamkang Chair Lecture Series, 129:59-75 (2001).
15
106. Yoon Jeong Park, Jun-Feng Liang, Hui Song, Yong T. Li, and Victor C. Yang. ATTEMPTS: A
Heparin/Protamine-Based Prodrug Approach for Delivery of Thrombolytic Drugs. Journal of
Controlled Release 72:145-156 (2001).
107. Betrice Tsui, Vijendra K. Singh, Jun-Feng Liang, and Victor C. Yang. Reduced Cross-Reactivity
Towards Anti-Protamine Antibodies of a Low Molecular Weight Protamine Analogue. Thrombosis
Research 101:417-420 (2001).
108. Yoon-Jeong Park, Jin Chang, Pen-Chung Chen, and Victor C. Yang. Poly(L-Lysine)-Based SemiInterpenetrating Polymer Network as pH-Responsive Hydrogel for Controlled Release of a Model
Protein Drug Streptokinase. Biotechnology and Bioprocess Engineering 6:1-6 (2001).
109. Tanya Wang, Youngro Byun, Jae-Seung Kim, and Victor C. Yang. A Protamine Bio-Reactor for
Extracorporeal Heparin Removal: In Vitro Modeling, Function Assessment, and Future Direction.
International Journal of Bio-Chromatography, 6:133-149 (2001).
110. Li-Chien Chang, Hsiao-Feng Lee, Zhi-Qiang Yang, and Victor C. Yang. Low Molecular Weight
Protamine (LMWP) as Non-Toxic Heparin/LMWH Antidote. [I]: Preparation and Characterization.
AAPS PharmSci 3(2) article 17 (2001) (http://www.pharmsci.org)
111. Li-Chien Chang, Jung-Feng Liang, Lai-Ming Lee, and Victor C. Yang. Low Molecular Weight
Protamine (LMWP) as Non-Toxic Heparin/LMWH Antidote. [II]: In Vitro Evaluation of Efficacy and
Toxicity. AAPS PharmSci 3(2) article 18 (2001) (http://www.pharmsci.org)
112. Lai-Ming Lee, Li-Chien Chang, Shirley Wrobleski, Thomas W. Wakefield, and Victor C. Yang. Low
Molecular Weight Protamine (LMWP) as Non-Toxic Heparin/LMWH Antidote. [III]: Preliminary In
Vivo Evaluation of Efficacy and Toxicity Using a Canine Model. AAPS PharmSci 3(2) article 19
(2001) (http://www.pharmsci.org)
113. Yoon-Jeong Park, Jun F. Liang, Zhiqiang Yang, and Victor C. Yang. Controlled Release of ClotDissolving Tissue Plasminogen Activator from a Poly(L-Glutamic Acid) Semi-Interpenetrating
Network Hydrogel. Journal of Controlled Release 75:37-44 (2001).
114. Junfeng Liang, Yoon Jeong Park, Hui Song, Sarita Naik, and Victor C. Yang. A Review of the
ATTEMPTS Approach in Delivering Enzyme Drugs. Proceedings of the Seventh Symposium on
Biomedical Materials & Technology, R.O.C, pp.26-31 (2001).
115. Yoon-Jeong Park, Jun-Feng Liang, Yong-Tao Li, Sarita Naik, and Victor C. Yang. ATTEMPTS: A
Heparin/Protamine-Based Delivery System for Enzyme Drugs. Journal of Controlled Release,
78:67-79 (2002)
116. Peter Markland, and Victor C. Yang. Biodegradable Polymers as Drug Carriers. Encyclopedia of
Pharmaceutical Technology, 2nd Ed. (J. Swarbrick, J.C. Boylan, eds.) pp 136-155, Marcel Dekker,
Inc. (2002).
117. Yuehua Zhang, Zhi-Qiang Yang, Peter Markland, and Victor C. Yang. Poly(glutamic acid)
Poly(ethylene glycol)
Hydrogels Prepared by Photo-Induced Polymerization: Synthesis,
Characterization, and Preliminary Release Studies of Protein Drugs. Journal of Biomedical
Materials Research 62:14-21 (2002).
118. Yoon Jeong Park, Junfeng Liang, Sarita Naik, and Victor C. Yang. Delivery of Catalytic
Macromolecular Drugs. Proceedings of the Third Asian Symposium on Biomaterials & Drug
Delivery Systems, R.O.C, in press (2003).
119. Junfeng Liang, Lan Zhen, Li-Chien Chang, and Victor C. Yang. A Less Toxic Heparin Antagonist:
Low Molecular Weight Protamine. Biochemistry (Moscow), 68:139-144 (2003).
16
120. An-Rong Lee, Li-Chien Chang, Victor C. Yang, Li-Heng Pao, and Da-Peng Wang. Applications of
Polyion-Sensitive Electrodes to Pharmaceutical Domain: A Mini-Review. Journal of Food and Drug
Analysis, 10:212-218 (2003).
121. Yoon Jeong Park, and Victor C. Yang. Bioconjugates for Effective Drug Targeting. Advanced Drug
Delivery Reviews (Park YJ and Yang VC, Theme Eds.), 55:169-170 (2003).
122. Yoon Jeong Park, Junfeng Liang, Hui Song, Yongtao Li, Sarita Naik, and Victor C. Yang.
ATTEMPT: A Heparin/Protamine-Based Triggered Release System for the Delivery of Enzyme
Drugs without Associated Side Effects. Advanced Drug Delivery Reviews (Park YJ and Yang VC,
Theme Eds.), 55:251-265 (2003).
123. Yong Tao Li, Jun Feng Liang, and Victor C. Yang. The Use of a Transduction Peptide as a
Possible Means for Enzyme Red Blood Cell Encapsulation. American Pharmaceutical Review 6:2326 (2003).
124. Yoon Jeong Park, Jun Feng Liang, Kyung Soo Ko, Sung Wan Kim, and Victor C. Yang. Low
Molecular Weight Protamine as an Efficient and Nontoxic Gene Carrier. Journal of Gene Medicine,
5:700-711 (2003).
125. Yoon Jeong Park, Sook Hee Nah, Jue Yeon Lee, Jae Min Jeong, Jun Key Chung, Myung Chul
Lee, Victor C. Yang, and Seung Jin Lee. Surface-modified Poly(lactic-co-glycolide) Nanospheres
for Targeted Bone Imaging with Enhanced Labeling and Delivery of Radioisotope. Journal of
Biomedical Materials Research, 67A:751-760 (2003).
126. Jun Feng Liang, Yoon Jeong Park, Jin Chang, and Victor C. Yang. ATTEMPTS: A Pharmaceutical
Engineering Approach for Delivery of Macromolecular Drugs. Frontiers in Biomedical Engineering
(Ned Huang, Peter Taijan, Eds.) Kluwer Academic Publisher, New York, pp. 168-178 (2004).
127. Pen-Chung Chen, Yoon Jeong Park, Li-Chien Chang, Robert H. Bartlett, and Victor C. Yang.
Injectable Microparticle-Gel System for Prolonged and Localized Lidocain Release (I): In Vitro
Characterization. Journal of Biomedical Materials Research, 70A:412-419 (2004).
128. Pen-Chung Chen, Daniel S. Kohane, Yoon Jeong Park, Robert H. Bartlett, Robert Langer, and
Victor C. Yang. Injectable Microparticle-Gel System for Prolonged and Localized Lidocain Release
(II): In Vivo Anesthetic Effects. Journal of Biomedical Materials Research 70A:459-466 (2004).
129. Junfeng Liang, Emel Emregul, and Victor C. Yang. Development of a Protamine-Hollow Fiber
Device for Extracorporeal Heparin Removal. Blood Purification 22:198-202 (2004).
130. Yongtao Li, Junfeng Liang, Yoon Jeong Park, Sarita S. Naik, Young Min Kwon, and Victor C.
Yang. An Innovative PTD-Mediated Protein Transduction Therapy for Cancer Treatment.
Proceedings of the 4th Asian Symposium on Biomaterials and Drug Delivery Systems, PP147-151
(2004).
131. Sarita Naik, Hui Song, Yoon Jeong Park, Junfeng Liang, and Victor C. Yang. Application of the
ATTEMPTS for Drug Delivery. Journal of Controlled Release, 101:35-45 (2004).
132. Li-Chien Chang, Hsiao Feng Lee, Meng Ju Chung, and Victor C. Yang. PEG-Modified Protamine
with Improved Pharmacological/Pharmaceutical Properties as a Potential Protamine Substitute:
Synthesis and In Vitro Evaluation. Bioconjugate Chemistry 16:147-155 (2005).
133. Yoon Jeong Park, Junfeng Liang, and Victor C. Yang. Nontoxic Membrane Translocation Peptide
from Protamine, LMWP, for Enhanced Intracellular Drug Delivery: In Vitro and In Vivo Studies.
FASEB Journal, 19:1555-1557 (2005).
134. Emel Emregul, Alan David, Joseph P. Balthasar, and Victor C. Yang. A GPIIb/IIIa Bioreactor for
Specific Treatment of Immune Thrombocytopenic Purpura (ITP), an Autoimmune Disease.
17
Preparation, In Vitro Characterization, and Preliminary Proof-of-Concept Animal Studies. Journal of
Biomedical Materials Research, 75A:648-655 (2005).
135. Victor C. Yang, Sarita Naik, Hui Song, Alan Dombkowski, Gordon Crippen, and Jun F. Liang.
Engineering of Heparin-Binding t-PA Mutants for Potential Application in Thrombolytic Therapy
without Associated Bleed Risks. Journal of Controlled Release, 110:164-176 (2005).
136. Tanya Wang, Zhiqiang Yang, Emel Emregul, Allan David, Joseph P. Balthasar, Junfeng Liang, and
Victor C. Yang. Strategies for Improving the Functionality of an Affinity Type Bioreactor.
International Journal of Pharmaceutics, 306:132-141 (2005).
137. Jun Feng Liang, Victor C. Yang, and Yekaterina Vaynshteyn. The Minimal Functional Sequence
of Protamine. Biophysical and Biochemical Research Communication, 336:653-659 (2005).
138. Junfeng Liang, and Victor C. Yang. Synthesis of Doxorubicin-Peptide Conjugate with Multidrug
Resistant Tumor-Killing Activity. Bioorganic & Medicinal Chemistry Letters, 15:5071-5075 (2005).
139. Jun Feng Liang, and Victor C. Yang. Insulin-Cell Penetrating Peptide Hybrids with Improved
Intestinal Absorption Efficiency. Biophysical and Biochemical Research Communication, 335:734738 (2005).
140. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Delivery of Macromolecular Drugs: From
ATTEMPTS Approach to PTD-Mediated Cellular Delivery. Proceedings of the 7th International
Symposium on Peptides and Biomaterials for Tissue Regeneration, pp. 5-9 (2005).
141. Victor C. Yang. “The ATTEMPTS Approach for Delivery of Macromolecular Drugs.” Proceedings
of the China-Japan Symposium on Pharmaceutical Preparations and Particulate Design, pp. 14-17
(2006).
142. Alan David, Victor C. Yang, and Arthur J. Yang. Chemically Surface Modified Gel (CSMG): An
Excellent Enzyme Immobilization Matrix for Industrial Processes. Journal of Biotechnology,
125:395-407 (2006).
143. Victor C. Yang. “Strategies for Developing Macromolecular Therapeutic Agents.” Proceedings of
the 282th Xiang Shan Meeting, pp. 4-11, Xiang Shan, China (2006).
144. Jue Yeon Lee, Kyung Hwa Kim, Yang Jo Seol, Victor C. Yang, Inho Jo, Seung Jin Lee, Chong
Pyoung Chung, and Yoon Jeong Park, Tat-Peptide Based Gene Delivery to Human Bone Marrow
Stromal Cells as a Platform for Tissue Regeneration: In vitro Study. Biomaterials Research 10
(4):218-223 (2006).
145. Choi YS, Lee JY, Kwon YM, Lee YK, Lee SJ, Chung CP, Yang VC, Park YJ, Enhanced Uptake of
Antisense Oligonucleotides and Suppression of bcl-2 Gene Expression in Human Breast Cancer
Cells Using Cell Permeable Peptide. Biomaterials Research 10 (4), 224-229 (2006).
146. Lee JY, Choo JE, Park JB, Lee SJ, Min DS, Pi SH, Lee KY, Yang VC, Chung CP, Park YJ,
Assembly of Collagen-Binding Peptide with Collagen as a Bioactive Scaffold for Osteogenesis In
Vitro and In Vivo. Biomaterials, 28:4257-4267 (2007).
147. Victor C. Yang, Young Min Kwon, Yoon Jeong Park, and Kang Zhao, Strategies for Designing
Delivery Systems for Macromolecular Drugs. Proceedings of the 3rd WACBE Symposium, pp 5557 (2007).
148. Beata Chertok, Allan David, Yongzhuo Huang, and Victor C. Yang. Glioma Selectivity of
Magnetically Targeted Nanoparticles: A Role of Abnormal Tumor Hydrodynamics. Journal of
Controlled Release, 122:315-323 (2007).
149. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Delivery Systems for Protein
Therapeutics. Proceedings of the 3rd International Pharmaceutical Symposium: Novel Drug
Delivery Systems: Research and Applications, pp109-112, Shanghai, China, October 19-21 (2007).
18
150. Cheol Moon, Young Min Kwon, Won Kyu Lee, Yoon Jeong Park, and Victor C. Yang. In Vitro
Assessment of a Novel Polyrotaxane-Based Drug Delivery System Integrated with a CellPenetrating Peptide. Journal of Controlled Release, 124:43-50 (2007).
151. Cheol Moon, Young Min Kwon, Won Kyu Lee, Yoon Jeong Park, Li-Chien Chang, and Victor C.
Yang. A Novel Polyrotaxane-Based Intracellular Delivery System for Camptothecin: In Vitro
Feasibility Evaluation. Journal of Biomedical Materials Research, 84A:238-246 (2007).
152. Beata Chertok, Brad A. Moffat, Allan David, Faquan Yu, Christian Bergemann, Brian D. Ross, and
Victor C. Yang. Magnetic Nanoparticles as an MRI-Visible Vehicle for Magnetically Targeted Drug
Delivery to Brain Tumors. Biomaterials 29:487-496 (2008).
153. Young Min Kwon, Yongtao Li, Jun Feng Liang, Yoon Jeong Park, and Victor C. Yang. PTDModified ATTEMPTS System for Enhanced Asparaginase Therapy: Preliminary Proof-of-Concept
Investigation. Journal of Controlled Release, 130:252-258, (2008).
154. Yongtao Li, Hongfang Wang, Gerald J. Spangrude, Jun Feng Liang, Yoon Jeong Park, Young Min
Kwon, and Victor C. Yang. Preliminary In Vivo Evaluation of the PTD-Modified ATTEMPTS
Approach in Enhancing Asparaginase Therapy. Journal of Biomedical Materials Research,
Published Online: September 23, (2008).
155. Young Min Kwon, Yongtao Li, Sarita Naik, Jun Feng Liang, Yongzhuo Huang, Yoon Jeong Park,
and Victor C. Yang. The ATTEMPTS Delivery System for Macromolecular Drugs. Expert Opinion
on Drug Delivery 5:1255-1266 (2008).
156. Beata Chertok, Allan David, and Victor C. Yang. Strategies for Enhanced Brain Tumor
Accumulation of Magnetic Nanoparticles for Potential Drug Delivery. Technical Proceedings of the
2008 NSTI Nanotechnology Conference and Trade Show. NSTI-Nanotech., Nanotechnology 2:811, (2008).
157. Shweta R. Urva, Beom Soo Shin, Victor C. Yang, and Joseph P. Balthasar. Highly sensitive high
performance liquid chromatographic assay for quantification of doxorubicin in mouse plasma and
tissues. Journal of Chromatography B 877:837-841 (2009) (IF: 3.21).
158. Jin Sook Suh, Jue Yeon Lee, Young Suk Choi, Faquan Yu, Victor C. Yang, Seung Jin Lee, Chong
Pyong Chung, and Yoon Jeong Park. Efficient Labeling of Mesenchymal Stem Cells Using Cell
Permeable Magnetic Nanoparticles. Biochemical Biophysical Research Communication, 379:669675 (2009) (IF:3.55).
159. Faquan Yu, and Victor C. Yang. Size-Tunable Synthesis of Stable Superparamagentic Iron Oxide
Nanoparticles for Potential Biomedical Applications. Journal of Biomedical Materials Research
92:1468-1475 (2009). PMID: 19402138. (IF:3.32)
160. Young Min Kwon, Hee Sun Chung, Cheol Moon, James Yockman, Yoon Jeong Park, Scott D.
Gitlin, and Victor C. Yang. L-Asparaginase Encapsulated Intact Erythrocytes for Treatment of
Acute Lymphoblastic Leukemia (ALL). Journal of Controlled Release 139:182-189 (2009). (IF: 7.16)
161. Faquan Yu, Yongzhuo Huang, Adam Cole, and Victor C. Yang. The Artificial Peroxidase Activity
of Magnetic Iron Oxide Nanoparticles and Its Application to Glucose Detection. Biomaterials
30:4716-4722 (2009). PMID: 19515418. (IF: 7.88)
162. Jin Shuan Chen, De Chuan Chan, Meng Ju Chung, Li-Chien Chang, and and Victor C. Yang.
Altered Fibrinolytic Activities in Gastric Cancer and Uremic Patients after Intervention. Clinical
Nephrology 72:468-472 (2009). (IF: 2.50)
163. Lei Zhang, Faquan Yu, Adam J. Cole, Beata Chertok, Allan David, Jingkang Wang, and Victor C.
Yang. Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous
Magnetic Targeting and Tumor Imaging. AAPS Journal 11:693-699 (2009). PMID: 19842043. (IF:
3.94)
19
164. Beata Chertok, Allan David, Bradford A. Moffat, and Victor C. Yang. Substantiating in vivo
Magnetic Brain Tumor Targeting of Cationic Iron Oxide Nanocarriers via Adsorptive Surface
Masking. Biomaterials 30:6780-6787(2009). PMID:19782394. (IF:7.88)
165. Shweta R. Urva, Victor C. Yang, and Joseph P. Balthasar. Development and Validation of an
Enzyme Linked Immunosorbent Assay for the Quantification of Carcinoembryonic Antigen in
Mouse Plasma. Journal of Immunoassay and Immunochemistry 30:418-427 (2009) (IF: 1.01).
166. Shweta R. Urva, Victor C. Yang, Joseph P. Balthasar. An ELISA for Quantificaiton of T84.66, a
Monoclonal Anti-CEA Antibody, in Mouse Plasma. Journal of Immunoassay and Immunochemistry
31:1-9 (2010). (IF: 1.01)
167. Shweta R. Urva, Victor C. Yang, and Joseph P. Balthasar. Physiologically Based Pharmacokinetic
Model for T88.46: A Monoclonal Anti-CEA Antibody. Journal of Pharmaceutical Sciences 99:15821600 (2010). (IF; 3.31)
168. Jun Beom Park, Young Min Kwon, Tien Yi Lee, Remy Brim, Mei-Chuan Ko, Roger K. Sunahara,
James H. Woods, and Victor C. Yang. Pegylation of Bacterial Cocaine Esterase for Protection
against Protease Digestion and Immunogenicity. Journal of Controlled Release 142:174-179
(2010). PMID:19857534. (IF: 7.16)
169. Huina Zhang, Lin Wang, Jun Beom Park, Paul Park, Victor C. Yang, Scott J. Hollister, Frank La
Marca, Chia-Ying Lin. Intradiscal Injection of Simvastatin Retards the Progression of Intravertebral
Disc Degeneration Induced by Stab Injury. Arthritis Research Therapy, 11(6):R172 (2010).
PMID:19912653. (IF: 2.20)
170. Yongzhuo Huang, Yoon Shin Park, Allan David, Meong Cheol Shin, and Victor C. Yang. A Novel
Method for Enabling Transcutaneous Protein Immunization, Angewandte Chemie 49:2724-2727
(2010). (IF: 12.73)
171. Beata Chertok, Adam Cole, Allan David, and Victor C. Yang. Comparison of ESR and ICP-EOS
Methodologies for Studying Biodistribution of Iron Oxide Nanoparticles in Magnetically Targeted
Rats. Molecular Pharmaceutics, 7(2):375-385 (2010). PMID: 20039676. (IF: 5.40)
172. Huining He, Weibing Dong, Junbo Gong, Jingkang Wang, and Victor C Yang. Developing
Macromolecular Therapeutics: The Future Drug-of-Choice. Frontiers of Chemical Engineering in
China, 1-8 (2009).
173. Yoon Shin Park, Yongzhuo Huang, Hee Sun Chung, Lindsay White, and Victor C Yang. Specific
Down Regulation of 3T3-L1 Adipocyte Differentiation by Cell-Permeable Antisense Oligonucleotide.
Journal of Controlled Release, 144:82-90 (2010). PMID: 20109509. (IF: 7.16)
174. Kyoung Ah Min, Faquan Yu, Victor C. Yang, Xinyuan Zhang, and Gus R. Rosania. Transcellular
Transport of Heparin-Coated Magnetic Iron Oxide Nanoparticles (Hep-MION) under the Influence
of an External Magnetic Field. Pharmaceutics, 2:119-135 (2010).
175. Young Suk Choi, Jue Yeon Lee, Jin Sook Suh, Young Min Kwon, Seung Jin Lee, Jun-Key Chung,
Dong Soo Lee, Victor C. Yang, Chong Pyong Chung, and Yoon Jeong Park, The Systemic
Delivery of siRNA by a Cell-Penetrating Peptide, Low Molecular Weight Protamine. Biomaterials
31:1429-1443 (2010). (IF: 7.88)
176. Beata Chertok, Allan David, and Victor C. Yang. PEI-Modified Iron Oxide Nanoparticles as a
Potential Drug Delivery Vehicle for Brain Tumors via Magnetic Targeting. Biomaterials 31:63176324 (2010). PMID: 20494439. (IF: 7.88)
177. Faquan Yu, Lei Zhang, Yongzhuo Huang, Kai Sun, Allan E. David, and Victor C. Yang. The
Magnetophoretic Mobility and Superparamagnetism of Core-Shell Iron Oxide Nanoparticles with
Dual Targeting and Imagnig Functionality. Biomaterials 31:5842-5848 (2010). PMID: 20434209. (IF:
7.88)
20
178. Yongzhuo Huang, Young Min Kwon, Cheol Moon, Yoon Shin Park, Jianxin Wang, Allan E. David,
and Victor C. Yang. ATTEMPTS System: A Macromolecular Prodrug Strategy for Cancer Drug
Delivery. Current Pharmaceutical Design, 16:2369-2376 (2010). (IF: 4.68)
179. Yongzhuo Huang, Faquan Yu, Yoon Shin Park, Meong-Cheol Shin, Lindsay White, and Victor C
Yang. Co-Administration of Protein Drugs with Gold Nanoparticles Enable Percutaneous Delivery.
Biomaterials, 31, 9087-9091 (2010). (IF: 7.88)
180. Jin Woo Park, Ok Cheol Jeon, Sang Kyoon Kim, Taslim Ahmed Al-Hilal, Shun Ji Jin, Hyun Tae
Moo, Victor C Yang, Sang Yoon Kim, and Youngro Byun. High Antiangiogenic and Low
Anticoagulant Efficacy of Orally Active Low Molecular Weight Heparin Derivatives. Journal of
Controlled Release, 148, 317-326 (2010). (IF: 7.16)
181. Jianxin Wang, Yongzhuo Huang, Allan E. David, Beata Chertok, Lei Zhang, Faquan Yu, and Victor
C. Yang. Magnetic Nanoparticles for Brain Tumor Imaging. Current Pharmaceutical Biotechnology,
in press (2011). (IF: 4.08)
182. Beata Chertok, Allan David, and Victor C. Yang. Magnetically Enabled and MR-Monitored
Selective Brain Tumor Protein Delivery in Rats via Magnetic Nanocarriers. Biomaterials, 32:62456253 (2011). PubMed PMID: 21632104 (IF: 7.88)
183. Beata Chertok, Allan David, and Victor C. Yang. Strategies for Enhanced Brain Tumor
Accumulation of Magnetic Nanoparticles for Potential Drug Delivery: Effect of Administration Route
and Magnetic Field Topography. Journal of Controlled Release, 155:393-399 (2011). PubMed
PMID: 21763736 (IF: 7.16)
184. Jue Yeon Lee, Young Suk Choi, Jin Sook Suh, Young Min Kwon, Seung Jin Lee, Chong Pyong
Chung, Victor C. Yang, and Yoon Jeong Park. Cell-Permeable Chitosan/Doxorubicin Conjugates
for the Treatment of Cancer. International Journal of Cancer, 128:2470-2480 (2011). PubMed
PMID: 20669230 (IF: 5.444)
185. Yongzhuo Huang, Victor C Yang, and Wen Quan Liang. Polysorbates Cationic Niosomes: A
Novel Delivery Vehicle for Gene Transfer. Journal of Biomedical Materials Research, 96:513-519
(2011). PubMed PMID: 21254382 (IF: 2.625)
186. Jun Beom Park, Huina Zhang, Chia-Ying Lin, Youngro Byun, Chong Pyoung Chung, and Victor C
Yang. Simvastatin maintains osteroblastic Viability while Promoting Differentiation by Partially
Regulating the Expresssions of Estrogen Receptors Alpha. Journal of Surgical Research, 174:278283 (2011). PubMed PMID: 21324392 (IF: 2.247)
187. Adam J. Cole, Allan E. David, Jianxin Wang, Craig J. Galban, Hannah L. Hill, and Victor C Yang.
Polyethylene Glycol Modified, Cross-Linked Starch Coated Iron Oxide Nanoparticles for Enhnaced
Magnetic Tumor Targeting. Biomaterials, 32:2183-2193 (2011). PubMed PMID: 21176955 (IF:
7.88)
188. Allan E. David, Adam J. Cole, Beata Chertok, Yoon Shin Park, and Victor C Yang. A Combined
Theoretical and In Vitro Modeling Approach for Predicting the Magnetic Capture and Retention of
Magnetic Nanoparticles In Vivo. Journal of Controlled Release, 152:67-75 (2011) PubMed PMID:
21295085 (IF: 7.16)
189. Jingwei Li, Liang Feng, Li Fan, Yuan Zha, Liangran Guo, Qizhi Zhang, Jun Chen, Zhiqing Pang,
Yuchen Wang, Xinguo Jiang, and Victor C. Yang. Screening Phage Display Libraries for the
Construction of Brain-Targeted Nanoparticles. Biomaterials, 32:4943-4950 (2011). PubMed PMID:
21470674 (IF: 7.88)
190. Adam J. Cole, Allan E. David, Jianxin Wang, Craig J. Galban, Hannah L. Hill, and Victor C Yang.
Magnetic Brain Tumor Targeting and Biodistribution of Long-Circulating, PEG-Modified, CrossLinked Starch Coated Iron Oxide Nanoparticles. Biomaterials, 32:6291-6301 (2011). PubMed PMID:
21684593 (IF: 7.88).
21
191. Adam J. Cole, Victor C Yang and Allan David. Cancer Theranostics: The Rise of Targeted
Magnetic Nanoparticles. Trends in Biotechnology, 29:2183-2193 (2011) PubMed PMID: 21489647
(IF: 9.148).
192. Choi YS, Lee JY, Suh JS, Lee SJ, Yang VC, Chung CP, Park YJ. Cell Penetrating Peptides for
Tumor Targeting. Current Pharmaceutical Biotechnology 12:1166-1182, (2011). PubMed PMID:
21470141 (IF: 2.805).
193. Allan E. David, Adam J. Cole, and Victor C. Yang, Magnetically-Targeted Nanoparticles for Brain
Tumor Therapy: What Does the Future Hold? Nanomedicine, 6:1133-1135 (2011) PubMed PMID:
21929450. (IF: 5.055).
194. Huining He, Allan E. David, Jian Zhang, Yoon Shin Park, Jianxin Wang, Yongzhuo Huang, and
Victor C. Yang. LMWP/Insulin Formulation in Attenuating Protamine-Masqueraded Insulin Allergy
in Diabetic Patients. Macromolecular Research, 19:1224-1226 (2011). (IF: 1.82).
195. Allan E. David, Junbo Gong, Beata Chertok, Roman C. Domszy, Nam Sun Wang, Victor C Yang,
and Arthur J. Yang. Immobilized Thermolysin Highly Efficient Production of Low Molecular Weight
Protamine – An Attractive Cell-Penetrating Peptide for Macromolecular Drug Delivery. Journal of
Biomedical Materials Research, 100A:211-219 (2012). PubMed PMID 22042599 (IF: 2.625).
196. Yoon Suk Jung, Jee-Heon Jeong, Simmyung Yook, Bok-Hyeolm, Jinwon Seo, Sung Woo Hong,
Jun-Beom Park, Victor C. Yang, Dong Yun Lee, and Youngro Byun. A Combination Protocol of
Surface Modification of Pancreatic Islets Using Heparin-DOPA Conjugate and Anti-CD154 Mab
Treatment for the Prolonged Survival of Intrahepatic Transplanted Islets in a Xenograft Model.
Biomaterials 33:295-303 (2012). PubMed PMID: 21982296 (IF: 7.88).
197. Ji-Young Kim, Gayong Shim, Hyun-woo Choi, Jooho Park, Seung Woo Chung, Sunil Kim,
Kwangmeyung Kim, Ick Chan Kwon, Chan-Wha Kim, Sang Yoon Kim, Victor C. Yang, Yu-Kyoung
Oh, Youngro Byun. Tumor Vasculature Targeting Following Co-Delivery of Heparin-Taurocholate
Conjugate and Suberoylanilide Hydroxamic Acid Using Cationic Nanolipoplex. Biomaterials
33:4424-4430, (2012). PubMed PMID: 22425551 (IF: 7.404)
198. Yoon Shin Park, Allan E. David, Younzhuo Huang, Jun-Beom Park, Victor C. Yang. In Vivo
Delivery of Cell Permeable Anti-Sense-H!F-Oligonucleotide to Adipose Tissue Reduces Adiposy
of Obese Rats. Journal of Controlled Release, 161:1-9 (2012). PubMed PMID: 22546680 (IF: 7.16)
199. Seung Rim Huang, Dong-Hyun Seo, Taslim A. Al-Hilal, Ok-Cheol Jeon, Jin Hee Kang, Sung-Hyun
Kim, Han Sung Kim, Young-Tae Chang, Young Mo Kang, Victor C. Yang, and Youngro Byun.
Orally Active Desulfated Low Molecular Weight Heparin and Deoxycholic Acid Conjugate, 60DSLHbD, Suppresses Neovascularizaiton and Bone Destruction in Arthritis. Journal of Controlled
Release, 163:374-384 (2012).
200. Asarasin Adulnirath., Seung Woo Chung, Jooho Park, Seung Rim Huang, Ji-Young Kim, Victor C.
Yang, Sang Yoon Kim, Hyun Tae Moon, and Youngro Byun. Cyclic RGDyk-Conjugated LMWHTaurocholate Derivative as a Targeting Angiognesis Inhibitor. Journal of Controlled Release,
164:8-16 (2012).
201. Wu X, Ruan J, Yang VC, Wu Z, Lou J, Duan H, Zhang J, Zhang Y, Guo D. Three new acetylated
benzyl-beta-resorcylate glycosides from Cassia obtusifolia. Fitoterapia. 2012(83): 166-169. doi:
10.1016/j.fitote.2011.10.009. PubMed PMID: 22040904. (IF: 1.848)
202. Jian Zhang, Dawei Deng, Hongyan Zhu, Jianpeng Xue, Youngro Byun, Yueqing Gu, and Victor C.
Yang. Folate-Conjugated, Thermo-Responsive Micelles for Tumor Targeting. Journal of Biomedical
Materials Research, in press (2012). (IF: 3.32).
22
203. Tien Yi Lee, Yoon Shin Park, George A. Garcia, Roger K. Sunahara, James H Woods, and Victor
C. Yang. Cell Permeable Cocaine Esterases Constructed by Chemical Conjugation and Genetic
Recombination. Molecular Pharmaceutics, 9:1361-1273 (2012). PubMed PMID: 22404344.
204. Ming Shen, Yongzhuo Huang, Limei Han, Jin Qin, Xiaoling Fang, Jianxin Wang, and Victor C
Yang. Multifunctional Drug Delivery System for Targeting Tumor and Its Acidic Microenvironment.
Journal of Controlled Release, 61:884-892 (2012). PubMed PMID: 22587941 (IF: 7.16).
205. Absar S, Choi S, Victor C. Yang, Kwon Young Min. Heparin-Triggered Release of Camouflaged
Tissue Plasminogen Activator for Targeted Thrombolysis. Journal of Controlled Release, 157:4654 (2012). PubMed PMID: 21930168 (IF: 7.16).
206. Yoon Shin Park, Allan E. Davis, Kyung Min Park, Chia Ying Lin, Shayan Rahman, Khoi D. Than,
Lin Wang, Kyuri Lee, Jun Beom Park, Ki Dong Park, and Victor C. Yang. Controlled Release of
Simvastin from In Situ Forming Hydrogel and its Triggered Bone Formation in MC3T3-E1 Cells.
AAPS Journal, in press (2012).
207. Huining He, Allan David, Beata Chertok, Adam Cole, and Victor Yang. Magnetic Nanoparticles for
Tumor Imagning and Therapy: A So-Called Theranostic System. Pharmaceutical Research, in
press (2013).
208. Yifan Jiang, Huiyuan Wang, Jianxin Wang, Huining He, Yanqin Liang, Victor C. Yang, and
Yongzhuo Huang. Curb Challenges of the “Trojan Horse” Approach: Smart Strategies in Achieving
Effective Yet Safe Cell-Penetrating Peptide Based Drug Delivery. Advanced Drug Delivery
Research, in press (2013). (IF: 12.16).
209. Kyoung Ah Min, Meong Cheol Shin, Faquan Yu, Meizhu Yang, Allan E. David, Victor C. Yang, and
Gus R. Rosania. Quantitative Analysis of Cell Barrier Penetration by Superparamagnetic Iron
Oxide Nanoparticles in a Pulsed Magnetic Field. ACS Nano, in press (2013).
210. Huining He, Junxiao Ye, Jianyong Sheng, Junbo Gong, Jianxin Wang, and Victor C. Yang.
Overcoming Oral Insulin Delivery Barriers: Application of Cell Penetrating Peptide and Silica-Based
Nanoporous Composites. Frontiers of Chemical Sciences and Engineering, in press (2013).
211. Junxiao Ye, Yongzhuo Huang, Junbo Gong, Huining He, and Victor C. Yang. Ultrasound-Mediated
Targeted Microbubbles: A New Vehicle for Cancer Therapy. Frontiers of Chemical Sciences and
Engineering, in press (2013).
212. Mi Young Lee, Meong Cheol Shin, and Victor C. Yang. Transcutaneous Antigen Delivery System.
Korean Society of Biochemistry and Molecular Biology, in press, (2013)
213. Huining He, Jianyong Sheng, Allan E. David, Young Min Kwon, Jian Zhang, Yongzhuo Huang,
Jianxin Wang, and Victor C. Yang. Monomeric Insulin and Low Molecular Weight Protamine
Chemical Chimera for Enhanced In situ Insulin Intestinal Absorption. Biomaterials, submitted
(2013). (IF: 7.404)
214. Meong Cheol Shin, Jian Zhang, Allan E. David, Wolfgang E. Trommer, Young Min Kwon, Kyoung
Ah Min, and Victor C. Yang. Enhanced anti-cancer activity of PTD-modified gelonin: A comparison
of chemical and recombinant synthesis. Journal of Controlled Release, in press (2013). (IF: 7.16).
215. Jian Zhang, Meong Cheol Shin, Allan E. David, Jie Zhou, Kyuri Lee, Huining He, and Victor C.
Yang Long-Circulating Heparin-Functionalized Magnetic Nanoparticles for Potential Application as
a Dual Imaging and Drug Delivery Platform. Nanoscale, submitted (2013).
216. Meong Cheol Shin, Jian Zhang, Kyoung Ah Min, Kyuri Lee, Youngro Byun, Allan E. David, and
Victor C. Yang. Cell-Penetrating Peptides: Achievements and Challenges in Application for
Cancer Treatment. Journal of Biomedical Materials Research, in press (2013).
217. Yinsong Wang, Huining He, Hee Sun Chung, Young Min Kwon, Youngro Byun, and Victor C.
Yang. Cell-Penetrating Peptides Provide a Novel Tool for Encapsulation of Protein Therapeutics
into Intact Red Blood Cells. Nanomedicine, submitted (2013).
23
218. Huining He, Yoon Shin Park, Allan E. David, Youngro Byun, Yong Zhuo Huang, Jianxin Wang,
Victor C. Yang. Covalent Coupling between Polycationic and Polyaionic Compounds with Inter- or
Intra-molecular Aggregation. Angewandte Chemie, submitted (2013). (IF: 12.73).
BOOK EDITED
1.
Charles G. Gebelein, Tai C. Cheng, and Victor C. Yang, Eds. Cosmetic and Pharmaceutical
Applications of Polymers, Plenum Press, New York and London (1992).
2.
Victor C. Yang, and That T. Ngo, Eds. Biosensors and Applications, Kluwer Academics/Plenum
Publishers, New York (2000).
3.
Victor C. Yang. Tamkang Chair Lecture Series, Vol. 129, Tamkang University Press, Taipei,
Taiwan (2001).
PATENTS
1.
Victor C. Yang, and Robert Langer. A Rapid Method for Determining an Isoelectric Point for
Amphoteric Molecules." U.S. Patent 4,666,855, May 19, 1987.
2.
Victor C. Yang, Howard Bernstein, Charles L. Cooney, and Robert Langer. Neutralization of the
Anticoagulant Activities of Low Molecular Weight Heparins. Patent pending.
3.
Victor C. Yang. Extracorporeal Blood Deheparinization System. U.S. Patent 4,800,016, January
24, 1989.
4.
Victor C. Yang. Extracorporeal Blood Deheparinization System. Canadian Patent 1,326,418,
January 25, 1994.
5.
Victor C. Yang. Filter Device for Rapid and Specific Removal of Heparin from Whole Blood and
Plasma Samples. U.S. Patent 5,000,854, March 19, 1991.
6.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang. Heparin-Selective Polymeric Membrane
Electrode. U.S. Patent 5,236,570, August 17, 1993.
7.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang. Heparin-Selective Polymeric Membrane
Electrode. European, Canada, Japan Patents Pending.
8.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang, "Heparin-Selective Polymeric Membrane
Electrode." U.S. Patent 5,453,171 (Continuation-in-part of U.S. Patent 5,236,570), September 25,
1995.
9.
Jong Hoon Yun, Mark E, Meyerhoff, and Victor C. Yang. Protamine-Responsive Polymeric
Membrane Electrode. U.S. Patent 5,607,567, March 4, 1997.
10.
Victor C. Yang, Robert H. Bartlett, and Bernhard O. Palsson. Photobioreactors and Closed
Ecological Life Support Systems and Artificial Lungs Containing the Same. U.S. Patent 5,614,378,
March 25, 1997.
11.
Victor C. Yang, and Youngro Byun. Protamine Fragment Compositions and Methods of Use. U.S.
Patent 6,624,141, September 23, 2003.
12.
Victor C. Yang, Junfeng Liang, and Yoon Jeong Park. Drug Delivery Compositions. US Patent
7,329,638, February 12, 2008, University of Michigan.
13.
Yoon Jeong Park, Li-Chien Chang, Junfeng Liang, and Victor C. Yang. Non-Toxic Membrane
Translocating Peptides, U.S. Patent 2007/0071677, September 9, 2005 (filed by ISTN, Inc., York,
PA).
14.
Allan David, Yoon Jeong Park, Victor C. Yang, Ruiyun Zhang, and Arthur J. Yang. Mucoadhesive
Nanocomposite Delivery System. PCT/US2005/017638 (filed by ISTN, Inc., York, PA) on
November 17, 2006.
24
15.
Allan David, Arthur J. Yang, Yoon Jeong Park, Jun Feng Liang, and Victor C. Yang. Innovative
Formulation for Oral Insulin Delivery. Provisional Patent (filed by ISTN, Inc., York, PA) August 3,
2007.
16.
Victor C. Yang, Yoon Min Kwon, Hee Sun Chung, and Arthur J. Yang. BBC-Encapsulated
Asparaginase for Enhanced Acute Lymphoblastic Leukemia Therapy. Provisional Patent (filed by
ISTN, Inc., York, PA) on December 20, 2007.
17.
Yongzhuo Huang, Yoon Jeong Park, Victor C. Yang, and Arthur J. Yang. Hepatitis B Vaccine
Transcutaneous Immunization. Provisional Patent (filed by ISTN, Inc., York, PA) on March 18,
2008.
18.
Victor C. Yang, Beata Chertok, and Allan David. Compositions and Methods for Targeting
Tumors. Provisional Patent (Application Number: 61,236686) was filed by University of Michigan
on August 25, 2009.
Donald Landry, Joanne McDonald, Shi Xian Deng, Chang Guo Zhan, Daquan Gao, James H.
Wood, Roger Sunahara, Diwahar L. Narasimhan, Victor C. Yang, Mei Chuan Holden Ko, John J.
Tesmer, Tien Yi Lee,and Young Min Kwon. Anti-Cocaine Compositions and Treatment. U.S.
Patent 8,318,156 B2, November 27, 2012 (jointly filed by Columbia University and the University of
Michigan).
19.
20.
Yoon Jeong Park, Chong-Pyoung Chung, and Victor C. Yang. Complex of Cell Translocational
Peptide and Magnetic Nanoparticles and Use Thereof. Filed by Seoul National University Industry
Foundation on February 10, 2008 (Priority: KR/02.10.07/KRA 20070099511).
21.
Yoon Jeong Park, Chong-Pyoung Chung, and Victor C. Yang. Target Activated Cell/Tissue
Translocation Peptide for Impermeable Compound Strategy, and Uses Thereof. European Patent
Application (EP 2399939A2), February 19, 2010.
ABSTRACTS
1.
Victor C. Yang, and Janice Barton. Isolation of Nucleation Fraction of Microtubules. Meeting-in
Miniature of the American Chemical Society, pp. 31, North Texas State University, Denton, Texas
(1976).
2.
Victor C. Yang, and Janice Barton. Polymerization Studies of Tubulin. Southwest Regional
Meeting of the American Chemical Society, pp. 24, Dallas-For Worth, Texas (1977).
3.
Victor C. Yang, and Robert Langer. Purification and Characterization of Heparinase. Fed. Proc.
43, 604 (1985).
4.
Victor C. Yang, Howard Bernstein, and Robert Langer. A Novel Approach for Neutralizing Low
Molecular Weight Heparin Fragments. Fed. Proc. 44, 1846 (1986).
5.
Victor C. Yang, Howard Bernstein, and Robert Langer. A Reactor for Removing Heparin at the
Termination of Extracorporeal Therapy. 189th National Meeting of the American Chemical Society,
Miami Beach, Florida (1985).
6.
Victor C. Yang, and Robert Langer. Large Scale Production of Catalytically Pure Heparinase.
Annual Meeting of American Institute of Chemical Engineers, pp. T-68 (1986).
7.
Victor C. Yang, Howard Bernstein, and Robert Langer. A Novel Approach for Diminishing Potential
Bleeding Risks Associated with the Use of Low Molecular Weight Heparins in the Extracorporeal
Therapy. ASAIO J. 16, 26 (1987).
8.
Victor C. Yang, Howard Bernstein, and Robert Langer. Heparinase
Characterization and Optimization. Enzyme Engineering IX, I-44 (1987).
9.
Victor C. Yang, and Ching-Leou C. Teng. A Protein-bound Polymeric Filter for Extracorporeal
Blood Deheparinization. Biotechnology Secretariat, 18, 195th National Meeting of the American
Chemical Society, Toronto, Canada (1988).
Immobilization:
25
10.
Victor C. Yang, Ching-Leou C. Teng, Lynne Crumbaugh, Friedrich K. Port, Thomas W. Wakefield,
and Gerd O. Till. A Protamine Filter for Extracorporeal Blood Heparin Removal. ASAIO J. 17, 68
(1988).
11.
Victor C. Yang, and Ching-Leou C. Teng. An Immobilized Protamine System for Removing
Heparin in Extracorporeal Blood Circulation. Pharmaceutical Research 5, S-35 (1988).
12.
Victor C. Yang. A Filter Device for the Prevention of Both Heparin and Protamine Induced
Complications Associated with Extracorporeal Therapy. Proceedings of the AAMI 24 Annual
Meeting & Exposition, pp. 99 (1989).
13.
Victor C Yang. A Simple and Rapid Protamine Titration Method. Proceedings of AAMI 24 Annual
Meeting & Exposition, pp. 99 (1989).
14.
Victor C. Yang, Ching-Leou C. Teng, Jae-Seung Kim, Christopher Vincent, Thomas W. Wakefield,
and Gerd O. Till. An Approach for the Prevention of Complications Associated with Extracorporeal
Blood Circulation. ASAIO J. 18, 64 (1989).
15.
Victor C. Yang. A Colorimetric Method for Rapid Determination of the Protamine Dose Required
for Heparin Reversal. ASAIO J. 18, 71 (1989).
16.
Victor C. Yang, and Alexander C.R. Tsuei. Phospholipid Derivatives: A Possible Means for
Controlled Delivery of Nucleoside Drugs. 16th International Symposium on Controlled Release of
Bioactive Materials, pp. 82 (1989).
17.
Weiliam Chen, and Victor C. Yang. Protamine Immobilization and Capillary Migration as an
Unorthodox Approach of Heparin Sensoring. Pharmaceutical Research 6, S-28 (1989).
18.
Victor C. Yang, Jae-Seung Kim, and Ching-Leou C. Teng. Immobilized Protamine: An Approach
for the Control of Complications Associated with Extracorporeal Therapy. Annual Meeting of the
American Institute of Chemical Engineers, pp. T-187 (1989).
19.
Victor C. Yang. Strategy Development Regarding Large Scale Protein Purification. 39th Canadian
Chemical Engineering Conference and 2nd International Conference on Separation and
Technology, pp. S-8d (1989).
20.
Alexander C.R. Tsuei, and Victor C. Yang. Ion-Exchange Hollow fibers. 199th International
Meeting of the American Chemical Society, Boston, Massachusetts (1990).
21.
You-Yin Fu, Ching-Leou C. Teng, and Victor C. Yang. A Rapid and Precise Whole Blood
Protamine Titration. ASAIO J. 19, 70 (1990).
22.
Victor C. Yang, and Jae-Seung Kim. Biopolymer Coupled with Heparin Antidote for In Vivo
Heparin Removal. 200th International Meeting of the American Chemical Society, Washington DC
(1990).
23.
You-Yin Fu, and Victor C. Yang. The Effect of Bound Protamine on the Blood Components During
Reversal of Heparin. Pharmaceutical Research 7, S-46 (1990).
24.
Jae-Seung Kim, and Victor C. Yang. An Unconventional Approach of Utilizing Protamine: The
Heparin Antidote." Pharmaceutical Research 7, S-40 (1990).
25.
Alexander C. R. Tsuei, Gordon L. Amidon, and Victor C. Yang. Block Peptide Polymers for Drug
Delivery: Synthesis and Preliminary Results. Pharmaceutical Research 7, S-171 (1990).
26.
Weiliam Chen, and Victor C. Yang. Evaluating the Effects of Plasma Components on the
Performance of a Newly Developed Heparin Sensing System. Pharmaceutical Research 7, S-47
(1990).
27.
Victor C. Yang, You-Yin Fu, and Jae-Seung Kim. Protamine-Coated Cuprophan: A Potential NonThrombogenic Hemodialysis Membrane with Improved Blood Compatibility. ASAIO J. 20, 86
(1991).
28.
Victor C. Yang, and Weiliam Chen. A Protamine-Mediated Heparin Sensing Device. ASAIO J. 20,
29 (1991).
26
29.
Jae Seung Kim, Victor C. Yang, and Gordon L. Amidon. Structure-Permeability and StructureActivity Relationship for ACE Inhibitors. Pharmaceutical Research 8, S-56 (1991).
30.
Youyin Fu, and Victor C. Yang. Biocompatibility of Protamine-Coated Membrane. Pharmaceutical
Research 8, S-56 (1991).
31.
Victor C. Yang. The Use of a Protamine Filter for the Prevention of Heparin and ProtamineInduced Complications During Extracorporeal Blood Circulation. The VIII Congress of the
International Society for Artificial Organs, pp. 14 (1991).
32.
Shu-Ching Ma, Mark E. Meyerhoff, and Victor C. Yang. A Sensor with Specific Response Toward
Heparin. Abstract #1028, Pittsburgh Conference, New Orleans, LA, March 9-13, 1992.
33.
Victor C. Yang, Shu-Ching Ma, and Jae-Seung Kim. Biopolymers for Heparin Removal and
Monitoring. 203rd Annual Meeting of the American Chemical Society, San Francisco, CA, April 610 (1992).
34.
Shu-Ching Ma, and Victor C. Yang. A Novel Electrochemical Heparin Sensor, Pharmaceutical
Research 9, S-69 (1992).
35.
Victor C. Yang, and Shu-Ching Ma. A System for Heparin Removal and Monitoring. Proceedings
of the Cardiovascular Sciences and Technology Conference, pp. 192, 1992.
36.
Victor C. Yang, Shu-Ching Ma, and Mark E. Meyerhoff. A Novel Electrochemical Heparin Sensor.
ASAIO J. 22, 23 (1993).
37.
Youyin Fu, and Victor C. Yang. A Means to Improve the Biocompatibility of Cellulosic Dialyzer
Membranes. ASAIO J. 22, 84 (1993).
38.
Victor C. Yang, Shu-Ching Ma, and Mark E. Meyerhoff. A Novel Electrochemical Sensor for Direct
Monitoring of Heparin in Clinical Whole Blood Specimens. Abst. #47, American Association for
Clinical Chemistry Annual Meeting, New York City, NY, July 11-15 (1993).
39.
Mark E. Meyerhoff, Victor C. Yang, Bin Fu, Jong Hoon Yun, and Shu-Ching Ma. Electrochemical
Sensor for Heparin: Development, Characterization, and Biomedical Applications. Science
Innovation '93 Abstract, pp. 30 (1993).
Thomas J. Cook, Gordon L. Amidon, and Victor C. Yang. The Use of Polypeptides as Controlled
Release Implants: In Vitro Investigation. Pharmaceutical Research 10 (1993).
40.
41.
Victor C. Yang, Mark E. Meyerhoff, Bin Fu, Jong H Yun, Julie S. Johnson, and Robert F. Baugh. A
Novel Electrochemical Sensor for Heparin. The Fourth IBC International Symposium on
Anticoagulant, Antithrombotic, and Thrombolytic, Boston, MA, September 27-29 (1993).
42.
Youyin Fu, Gerd O. Till, Jacob N. Shanberge, and Victor C. Yang. Biocompatibility of the
Protamine-Coated Cellulosic Dialyzer Membranes. ASAIO J. 23, 24 (1994).
43.
Jong Hoon Yun, Mark E. Meyerhoff, and Victor C. Yang. A Disposable Coated-Wire Heparin
Sensor. ASAIO J. 23, 25 (1994).
Mark E. Meyerhoff, Victor C. Yang, Bin Fu, Jong Hoon Yun, Eric Bakker, and Shu-Ching Ma.
Polymer Membrane-Based Polyion Sensors: Development, Response Mechanism, and
Bioanalytical Applications. American Chemical Society Central and Great Lakes Regional Meeting,
Ann Arbor, Michigan, May 31 (1994).
44.
45.
Victor C. Yang, Jong Hoon Yun, Shu-Ching Ma, and Mark E. Meyerhoff. A Sensor-Directed BioFeedback Heparin Removal System. American Chemical Society Central and Great Lakes
Regional Meeting, Ann Arbor, Michigan, May 31- June 3 (1994).
46.
Victor C. Yang, Shu-Ching Ma, and Mark E. Meyerhoff. A Novel Electrochemical Heparin Sensor."
Proceedings of 21st International Symposium on Controlled Release of Bioactive Materials. pp.
274-275 (1994).
47.
Victor C. Yang, Hai-Han Kuo, and Shu-Ching Ma. A Bio-Feedback Drug Removal System.
Proceedings of 21st International Symposium on Controlled Release of Bioactive Materials, pp. 9596 (1994).
27
48.
Thomas J. Cook, Gordon L. Amidon, and Victor C. Yang. Protein Release from Poly(Amino Acid)
Microspheres. Pharmaceutical Research 11, S-323 (1994).
49.
Lai-Ming Lee, Jong-Hoon Yun, Joyce Wahr, Mark E. Meyerhoff, and Victor C. Yang. A
Disposable, Coated-Wire, Electrochemical Heparin Sensor. The Sixteenth Annual Undergraduate
Research Seminar, West Virginia University, October 17 (1994).
50.
Youngro Byun, Jong-Hoon Yun, Youyin Fu, and Victor C. Yang. A Protamine Filter for
Extracorporeal Heparin Removal: Development, Blood Compatibility Evaluation, and Future
Direction. ASAIO J. 24, 64 (1995).
51.
Jong-Hoon Yun, Lai-Ming Lee, Joyce Wahr, Mark E. Meyerhoff, and Victor C. Yang. Clinical
Application of Disposable Heparin Sensors: Blood Heparin Measurements during Open Heart
Surgery. ASAIO J. 24, 25 (1995).
52.
Bib Fu, Jong Hoon Yun, Lai-Ming Lee, Eric Bakker, Victor C. Yang, Joyce A. Wahr, and Mark E.
Meyerhoff. Polymer Membrane-Based Potentiometric Heparin (Polyion) Sensor: Response,
Mechanism and Biomedical Applications. American Association of Clinical Chemists Annual
Meeting, Anaheim, CA (1995).
53.
Mark E, Meyerhoff, Victor C. Yang, Joyce A. Wahr, Lai-Ming Lee, Jong Hoon Yun, Bin Fu, and
Eric Bakker. Potentiometric Polyion Sensors: A New Measurement Technology for Monitoring
Blood Heparin Levels During Open Hear Surgery. Oak Ridge Conference (1995).
54.
Joyce A. Wahr, Mark E, Meyerhoff, Victor C. Yang, Jong Hoon Yun, Lai-Ming Lee, and Xiao Chun
Lou. Accuracy of a New Heparin Responsive Electrochemical Sensor. American Society of
Anesthesiologists (1995).
55.
Victor C. Yang, Jong Hoon Yun, Bin Fu, Joyce Wahr, and Mark E. Meyerhoff. Novel
Electrochemical Heparin Sensor. The Xth World Congress of the International Society for Artificial
Organs, Taipei, Taiwan (1995).
56.
Victor C. Yang, Youngro Byun, and Ching-Leou C. Teng. A Protamine Filter for the Prevention of
Both Heparin- and Protamine-Induced Complications During Extracorporeal Blood Circulation. The
Xth World Congress of the International Society for Artificial Organs, Taipei, Taiwan (1995).
57.
In Suk Han, Jong Hoon Yun, Youngro Byun, Mark E. Meyerhoff, and Victor C. Yang. A Novel
Assay for Chymotrypsin Utilizing a Protamine-Responsive Polymer membrane Electrode as the
Probe. Molecular Biology of the Cell 6, p445 (1995).
58.
Youngro Byun, Tanya Wang, Jae-Seung Kim, and Victor C. Yang. Optimization and Assessment
of the In Vivo Efficacy of a Heparin-Removing Bio-Reactor Using Mathematical Modeling. ASAIO J.
42, 58 (1996).
59.
Victor C. Yang, and Mark E. Meyerhoff. A Novel Electrochemical Heparin Sensor: Principles and
Practice. Medical Engineering Week of the World, 2, 271 (1996).
60.
Youngro Byun, Tanya Wang, and Victor C. Yang. A Protamine Bioreactor for Extracorporeal
Heparin Removal: Development, In Vitro Modeling, and In Vivo Testing. Medical Engineering Week
of the World, 2, 295 (1996).
61.
Peter Markland, Gordon Amidon, and Victor C. Yang. Modified Poly(amides) as Drug Delivery
Matrices: Effects of Hydrophilicity and Structure on Drug Release. Pharmaceutical Research 13, S294 (1996).
62.
Tanya Wang, Youngro Byun, Jae-Seung Kim, and Victor C. Yang. Heparin-Removing Bioreactor
System: Adsorption Kinetics and Two-Compartment Model Elimination. Pharmaceutical Research
13, S-106 (1996).
Jong Hoon Yun, In Suk Han, Narayanan Ramamurthy, Ulrick Schaller, Mark E. Meyerhoff, and
Victor C. Yang. A Novel Design of Protease Assays Utilizing a Protamine-Responsive Membrane
Electrode. ASAIO J. 43 (1997).
63.
28
64.
Yuehua Zhang, Vijendra K. Singh, and Victor C. Yang. Enhancing Protamine Loading and Heparin
Adsorption on the Cellulose Hollow Fibers Utilizing Poly-L-Lysine Surface Amplification and
Poly(Ethylene Glycol) Spacer Arm Attachment. Pharmaceutical Research 14, S-163 (1997).
65.
Peter Markland, Ngoc-Anh Nguyen, Amy Miles, Victor C. Yang, and Gordon L. Amidon. Synthesis
and Characterization of Novel Poly(Amino Acid) pH-Sensitive Hydrogels. Pharmaceutical Research
14, S-292 (1997).
66.
Yuehua Zhang, and Victor C. Yang. Novel Approach for Optimizing the Capacity and Efficacy of a
Protamine Filter for Clinical Extracorporeal Heparin Removal. ASAIO J. 44, 27 (1998).
67.
Youngro Byun, and Victor C. Yang. A Delivery System for Targeted Thrombolysis without the Risk
of Hemorrhage. ASAIO J. 44, 86 (1998).
68.
Victor C. Yang, Jong Hoon Yun, Narayanan Ramamurthy, and Mark E. Meyerhoff. Biosensors for
Polyionic Drugs: Principle and Biomedical Applications. Proceedings of International Symposium of
Controlled Release of Bioactive Materials, 25 (1998).
69.
Tanya Wang, Yuehua Zhang, and Victor C. Yang. Improved Protamine Immobilization for
Removal of Heparin Using Poly-L-Lysine and Polyethylene Oxide. Annals of Biomedical
Engineering 26, P852, S-128 (1998).
70.
Tanya Wang, Yuehua Zhang, and Victor C. Yang. Improved Protamine Immobilization for
Removal of Heparin Using Poly-L-Lysine and Polyethylene Oxide. AAPS PharmSci (Supplement)
1, 97 (1998).
71.
Peter Markland, Yuehua Zhang, Gordon L. Amidon, and Victor C. Yang. Release of
Macromolecular Drugs from a pH-Sensitive Polypeptide Hydrogel Consisting of Polyglutamic Acid
and Polyethylene Oxide. AAPS PharmSci (Supplement) 1, 415 (1998).
72.
Vijendra K. Singh, Sheren X. Lin, and Victor C. Yang. Linking Measles Virus, Human Herpsevirus6, and Helicobacter Pylori to Antoimmunity in Autism. NIEHS Workshop on Environmental Agents
and Autoimmune Diseases, Research Triangle Park, North Carolina, September 1-3 (1998).
73.
Vijendra K. Singh, Elaine Yu, Betrice Tsui, and Victor C. Yang. Autoantibodies Reacting to
Different Brain Regions in Autism. The 10th International Congress of Immunology, New Delhi,
India, November 1-6 (1998).
74.
Peter Markland, Yuehua Zhang, Gordon L. Amidon, and Victor C. Yang. Polypeptide-Based Drug
Delivery Systems: From Diffusion Controlled Carriers to Hydrogels. Abstracts of the 9th JapaneseAmerican Conference on Pharmacokinetics and Biopharmaceutics, pp. 30, Nagoya, Japan, July
29-31 (1998).
75.
Jun-Feng Liang, Hui Song, Yongtao Li, and Victor C. Yang. The ATTEMPTS Approach for
Delivery of Catalytic Drugs Without Associated Toxic Effects. The 18th Pharmaceutical Technology
Conference, Ultrecht, The Netherlands, April 13-15 (1999).
76.
Jun-Feng Liang, Hui Song, and Victor C. Yang. A Novel Recombinant Approach for Targeted
Thrombolysis without the Risk of Bleeding. ASAIO J. 45, 198 (1999).
77.
Youngro Byun, Li-Chien Chang, Lai-Ming Lee, and Victor C. Yang. Low Molecular Weight
Protamine: A Potent but Non-Toxic Antagonist to Heparin/LMWH. ASAIO J. 45, 209 (1999).
78.
Ngoc-Anh Nguyen, Doo-Man Oh, Cheng-Pang Hue, Manas Mandal, Victor C. Yang, and Gordon
L. Amidon, Intracellular Uptake of PLGA Nanoparticles in Caco-2 Cells. AAPS Western Regional
Meeting, San Diego, CA, April 29-30 (1999).
79.
Junfeng Liang, and Victor C. Yang. ATTEMPTS: A Novel Approach for Delivery of Enzyme Drugs.
Proceeding of the Global Chinese Symposium on Biomaterials and Controlled Release, 39, Taipei,
Taiwan, October 28-29 (1999).
80.
Li-Chien Chang, Mark E. Meyerhoff, and Victor C. Yang. A Novel Method for Determining
Plasminogen Activators in Plasma Using Protamine Sensitive Sensor. AAPS PharmSci
(Supplement) 1,S-555 (1999).
29
81.
Ngoc-Anh Nguyen, Ching-Leou Teng, Kyung-Dall Lee, Doo-Man Oh, Victor C. Yang, and Gordon
L. Amidon. Starburst Polyamidoamine (PAMAM) Dendrimers Enhance Uptake and Transport of
Antisense Oligonucleotide in Caco-2 Cells. AAPS PharmSci (Supplement) 1,S-520 (1999).
82.
Jun F. Liang, Yong T. Li, and Victor C. Yang. A Novel Delivery System for Tissue Plasminogen
Activator. AAPS PharmSci (Supplement) 1,S-137 (1999).
83.
Hui Song, Jun F. Liang and Victor C. Yang. A Recombinant Tissue Plasminogen Activator (t-PAPoly(Arg)7 Chimera, for Targeted Thrombolysis without Bleeding Risk. AAPS PharmSci
(Supplement) 1,S-444 (1999).
84.
Zhiqiang Yang, Peter Markland, Yuehua Zhang, Gordon L. Amidon, and Victor C. Yang. Exploring
New Drug Delivery Platform: Synthesis, Characterization and Preliminary Protein Release of a pHResponsive Hydrogel. AAPS PharmSci (Supplement) 1,S-445 (1999).
85.
Lai-Ming Lee, Li-Chien Chang, and Victor C. Yang. Development of Protamine Alternative (Low
Molecular Weight Protamine) for Heparin Neutralization. AAPS PharmSci (Supplement) 1,S-556
(1999).
86.
Tanya Wang, Yuehua Zhang, and Victor C. Yang. Improved In Vitro Model of Heparin Removal by
Protamine Bioreactor. AAPS PharmSci (Supplement) 1,S-140 (1999).
87.
Junfeng Liang, Hui Song, Yongtao Li, and Victor C. Yang. ATTEMPTS: A Novel Approach for
Delivery of Enzyme Drugs without Associated Toxic Effects. Sixth European Symposium on
Controlled Drug Delivery, pp 51-52, Noordwijk Aan Zee, The Netherlands, April 12-14 (2000).
88.
Sheng Dai, Li-Chien Chang, Victor C. Yang, and Mark E. Meyerhoff. Application of Polyion
Sensitive Membrane Electrode and Optodes for Monitoring Plasminogen Activators. Pittsburgh
Conference, New Orleans, LA, March 12-17 (2000).
89.
Li-Chien Chang, Jun F. Liang, and Victor C. Yang. Characterization of Low Molecular Weight
Protamine (LMWP) as a Potential Non-Toxic Heparin Antidote. AAPS PharmSci (Supplement) 2,
401 (2000).
90.
Jun Feng Liang, Zhi Q. Yang, and Victor C. Yang. Synthesis and Pharmacokinetic Study of
Pegylated Heparin. AAPS PharmSci (Supplement) 2, 1165 (2000).
91.
Yong T. Li, Jun F. Liang, and Victor C. Yang. A Novel Delivery System for Tissue Plasminogen
Activator. AAPS PharmSci (Supplement) 2, 2259 (2000).
92.
Hui Song, Sarita S. Naik, and Victor C. Yang. Characterization of Tissue Plasminogen Activator (tPA) Mutants for Potential Use in Targeted Thrombolysis without Bleeding Risks. AAPS PharmSci
(Supplement) 2, 2258 ( 2000).
93.
Ngoc-Anh Nguyen, Jun F. Liang, Victor C. Yang, and Gordon L. Amidon. Characterization of
Antisense Oligonucleotide-Starburst PolyAmido Amine (PAMAM) Dendrimer Complexes. AAPS
PharmSci (Supplement) 2, 2384 (2000).
94.
Pen-Chung Chen, Yoon Jeong Park, Robert H. Bartlett, and Victor C. Yang. Lidocaine Releasing
Poly (D,L-Lactide) Microparticulate Systems for Localized and Prolonged Anesthetic Efficacy.
AAPS PharmSci (Supplement) 2, 2268 (2000).
95.
Yoon Jeong Park, Pen-Chung Chen, and Victor C. Yang. Poly(L-Lysine) Based pH-Sensitive
Hydrogel for Controlled Drug Release. AAPS PharmSci (Supplement) 2, 2266 (2000).
96.
Lai Ming Lee, Li-Chien Chang, Shirley K. Wrobleski, Thomas W. Wakefield, and Victor C. Yang. A
Low Molecular Weight Protamine (LMWP) Fragment for Nontoxic and Effective Reversal of
Heparin Anticoagulation in a Canine Model. AAPS PharmSci (Supplement) 2, 1836 (2000).
97.
Victor C. Yang. Approaches for Delivery of Thrombolytic Drugs. International Symposium on
Biomaterials and Drug Delivery Systems, pp 11-12, Cheju Island, Korea, August 20-22 (2000).
98.
Victor C. Yang. Overview of Drug Delivery Systems. 1st Taipei Biotech Fair, pp 107, Taipei,
Taiwan (2000).
30
99.
Victor C. Yang. Approaches for Designing Novel Delivery Systems Using our ATTMPTS System
for Delivery of Enzyme Drugs as an Example. The 1st Taipei Biotech Fair, pp 108, Taipei, Taiwan
(2000).
100. Junfeng Liang, Zhiqiang Yang, Sarita Naik, and Victor C. Yang. Comparison of the
Pharmacokinetics of Heparin and Pegylated Heparin. Pharmaceutical Congress of the Americas
pp144, Orlando, Florida, March 24-29 (2001).
101. Yong T. Li, Jun F. Liang, and Victor C. Yang. A Novel Heparin/Protamine-Based Drug Delivery
System. AAPS PharmSci (Supplement) 3 (2001).
102. Pen-Chung Chen, Yoon Jeong Park, Li-Chien Chang, Robert H. Bartlett, and Victor C. Yang.
Lidocaine-Releasing Microsphere-Gel System for Localized Anesthetic Efficacy. AAPS PharmSci
(Supplement) 3 (2001).
103. Lai-Ming Lee, Li-Chien Chang, William P. Fay, Mark E. Meyerhoff, and Victor C. Yang.
Electrochemical Determination of Low-Molecular Weight Heparins Using a Polyion-Sensitive
Membrane Electrode. AAPS PharmSci (Supplement) 3, (2001).
104. Jun F. Liang, Sarita S. Naik, Zhi Yang, Hsiao-Feng Lee, Li-Chien Chang, and Victor C. Yang.
Synthesis and Pharmacokinetic Study of Pegylated Heparin. AAPS PharmSci (Supplement) 3
(2001).
105. Jun F. Liang, Lan Zheng, Li-Chien Chang, and Victor C. Yang, “Studies on the Immunogenicity and
Toxicity of Low Molecular Weight Protamine.” AAPS PharmSci (Supplement) 3 (2001).
106. Yoon Jeong Park, Jun F. Liang, Ziquiang Yang, Jin Chang, and Victor C. Yang. Controlled
Release of Clot-Dissolving Tissue-Type Plasminogen Activator from A Polypeptide SemiInterpenetrating Polymer Network Hydrogel. AAPS PharmSci (Supplement) 3 (2001).
107. Jin Chang, Yoon Jeong Park, and Victor C. Yang, “Oligonucleotide-PLA-O-CMC Nanoparticles: A
Promising Delivery System fro Human Malignant Glioma Gene Therapy.” AAPS PharmSci
(Supplement) 3 (2001).
108. Victor C. Yang, Jin Chang, Sarita Naik, Yoon Jeong Park, and Junfeng Liang, “Delivery of Catalytic
Macromolecular Drugs.” The 3rd Asian International Symposium on Biomaterials and Drug Delivery
Systems, Taipei, Taiwan, 23 (2002).
109. Jin Chang, Junfeng Liang, Yoon Jeong Park, Hai F. Liu, and Victor C. Yang. Preparation and
Release Study of Anti-Cancer Drug-Loaded PLA-Gelatin Nanospheres. Particle Conference,
Orlando, Florida, (2002).
110. Jin Chang, Junfeng Liang, Yoon Jeong Park, Hai F. Liu, and Victor C. Yang. A Novel and
Promising Gene Delivery System for Human Malignant Glioma Therapy. Particle Conference,
Orlando, Florida, (2002).
111. Yoon Jeong Park, Jin Chang, Junfeng Liang, Li-Chien Chang, Kyung Soo Ko, Sung Wan Kim, and
Victor C. Yang. Low Molecular Weight Protamine as a Possible Nontoxic Gene Delivery Carrier.
The 29th Controlled Release Society Meeting, Seoul, Korea, July 22-26 (2002).
112. Yoon Jeong Park, Junfeng Liang , Zhiqiang Yang, Pen-Chung Chen, Jin Chang, and Victor C.
Yang. Poly(L-Glutamic Acid) Semi-Interpenetrating Polymer Network Hydrogel as a Controlled
Release Carrier for Clot-Dissolving Tissue-Type Plasminogen Activator. The 29th Controlled
Release Society Meeting, Seoul, Korea, July 22-26 (2002).
113. Junfeng Liang , Yongtao Li, Hui Song, Yoon Jeong Park, and Victor C. Yang. ATTEMPTS: A
Delivery System for Macromolecular Drugs. The 29th Controlled Release Society Meeting, Seoul,
Korea, July 22-26 (2002).
114. Junfeng Liang, Lan Zheng, Li-Chien Chang, and Victor C. Yang. A Non-Toxic Heparin Antagonist:
Low Molecular Weight Protamine. AAPS PharmSci (Supplement) 4 (2002).
115. Junfeng Liang, Yongtao Li, and Victor C. Yang. Attachment to a Membrane Translocation Peptide
Could Overcome the Multidrug Resistance (MDR) Effect of the Anti-Cancer Drug. AAPS PharmSci
(Supplement) 4 (2002).
31
116. Yongtao Li, Junfeng Liang, and Victor C. Yang. The Use of a Transduction Peptide as a Possible
Means for Protein Encapsulation. AAPS PharmSci (Supplement) 4 (2002).
117. Pen-Chung Chen, Yoon Jeong Park, Robert Bartlett, Daniel Kohane, Li-Chien Chang, Robert
Langer, and Victor C. Yang. Lidocaine-Releasing Microsphere-Gel System for In Vivo Localized
Anesthetic Efficacy.” AAPS PharmSci (Supplement) 4 (2002).
118. Sarita S. Naik, Junfeng Liang, Hui Song, and Victor C. Yang. Construction and Characterization of
a Tissue Plasminogen Activator Mutant for Potential Use in Thrombolytic Therapy with Reduced
Bleeding Tendency. AAPS PharmSci (Supplement) 4 (2002).
119. Lai Ming Lee, Sam Ye, Mark E. Meyerhoff, Michael J. Lim, William P. Fay, and Victor C. Yang.
Monitoring Low Molecular Weight Heparins Using Planar Protamine-Sensitive Polymer Membrane
Sensors. AAPS PharmSci (Supplement) 4 (2002).
120. Li-Chien Chang, Hsiao-Feng Lee, Lai Ming Lee, and Victor C. Yang. Low Molecular Weight
Protamine Peptide for Non-Toxic Heparin Neutralization. The 62nd World Congress of Pharmacy
and Pharmaceutical Sciences, Nice, France, August 31-September 5, 2002.
121. Victor C. Yang. Application of Biotechnology to the Development of Novel Drug Delivery Systems
Using t-PA as the Model Enzyme Drug. AACP 2003 Paul Dawson Biotechnology Award
presentation, Minneapolis, MN, July 23, 2003.
122. Yoon Jeong Park, Cheol Moon, Junfeng Liang, K Ko, and Victor C. Yang. Low Molecular Weight
Protamine as an Efficient and Non-Toxic Carrier for Therapeutic Gene and Protein Delivery. AAPS
PharmSci (Supplement) 5, No. T3907 (2003).
123. Pen Chung Chen, Yoon Jeong Park, Dan S. Kohane, Li-Chien Chang, Robert S. Langer, Robert H.
Bartlett, and Victor C. Yang. In Vivo Prolonged Local Anesthetic Effects from Injectable
Microparticle-Gel System. AAPS PharmSci (Supplement) 5, No. W4104 (2003).
124. Yong Tao Li, H.F. Wang, Yoon Jeong Park, Jun Feng Liang, G.J. Spangrude, and Victor C. Yang.
TAT-Mediated Intracellular Asparaginase Delivery for Cancer Therapy. AAPS PharmSci
(Supplement) 5, No. W5079 (2003).
125. Sarita Naik, Yongtao Li, Yoon Jeong Park, Junfeng Liang, and Victor C. Yang. Application of the
ATTEMPTS for Drug Delivery. Abstract of the Korean Society of Pharmaceutics Annual Meeting,
pp. 69, Seoul, Korea, November 27, 2003.
126. Yoon Jeong Park, Seung Jin Lee, Victor C. Yang, June Key Chung, and Chong Pyong Chung.
Surface Modification for Drug Delivery and Tissue Engineering Purpose. Abstract of the Korean
Society of Pharmaceutics Annual Meeting, pp. 72, Seoul, Korea, November 27, 2003.
127. Sarita S. Naik, Jun Feng Liang, and Victor C. Yang. In Vivo Characterization of a Targeted
Thrombolysis Delivery System Using a Rat Thrombosis Model. Pharmaceutical Sciences World
Congress, Kyoto, Japan, May 29-June 3 (2004).
128. Sarita Naik, Yongtao Li, Jun Feng Liang, and Victor C. Yang. Application of the ATTEMPTS for
Drug Delivery. Eighth European Symposium on Controlled Drug Delivery, pp 15-16, Noorwijk aan
Zee, The Netherlands, 2004.
129. Li-Chien Chang, Hsiao Feng Lee, Meng Ju Chung, and Victor C. Yang. PEG-Modified Protamine
with Improved Pharmacological/Pharmaceutical Properties as a Potential Protamine Substitute:
Synthesis and In Vitro Evaluation. The 31th Controlled Release Society Meeting, Hawaii, June 1417, 2004.
130. Victor C. Yang. ATTEMPTS: A Novel System for Delivery of Enzyme Drugs. Abstract of the 10th
SCBA (Society of Chinese Bioscientists in America) International Symposium, PP131-132, Beijing,
China, July 18-23, 2004.
131. Victor C. Yang. Heparin: A Clinical Polysaccharide Drug and an Excipient in the Design of Drug
Delivery System. Abstract No. 49, The 228th American Chemical Society Meeting, Philadelphia,
Pennsylvania, August 22-25, 2004.
32
132. Yong Tao Li, Jun Feng Liang, and Victor C. Yang. Cationic Peptides Used in DNA Condensation
and Gene Delivery. The AAPS Journal (Supplement) 6, No. T3076 (2004).
133. Victor C. Yang, Young Min Kwon, Beata Chertok, and Yoon Jeong Park. Novel Approach for
Simultaneous MR Imaging and Protein Transduction Therapy for Breast Cnacers. Proceeding of
the Era-of-Hope of Department of Defense (DOD) Breast Cancer Research Symposium, P67-20,
pp. 479, Philadelphia, PA, June 8-11, 2005.
134. Cheol Moon, Won Kyu Lee, Yoon Jeong Park, and Victor C. Yang. Construction and in Vitro
Characterization of Novel Drug Delivery System Based on Polymer-Bound Protein Transduction
Domain for Potential Cancer Therapy. AAPS Journal (Supplement), Nashville, Tennessee,
November 6-10, 2005.
135. . Delivery of Macromolecular Drugs: From ATTEMPTS Approach to PTD-Mediated Cellular
Delivery. Chinese 2005 National Meeting of Outstanding PhD Students in Chemical Engineering,
Tianjin, China, August 12-14, 2005.
136. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Delivery of Macromolecular Drugs: From
ATTEMPTS Approach to PTD-Mediated Cellular Delivery. 7th International Symposium on Peptides
and Bimaterials for Tissue Regeneration, pp. 5-9, Seoul, Korea, August 29, 2005.
137. Beata Chertok, Bradford A. Moffat, Allan E. David, and Victor C. Yang. Magnetic Nanoparticles
for Possible Simultaneous MR Imaging and Drug Therapy of Brain Tumors. Particles 2006,
Orlando, Florida, May 13-16, 2006.
138. Beata Chertok, Victor C. Yang, and Bradford Moffat. Magnetic Resonance Imaging of
magnetically targeted nanoparticles in an orthotopic 9L gliosarcoma brain tumor model. Fifth
Annual Meeting of the Society for Molecular Imaging, Waikola, Hawaii, August 30-September 2,
2006.
139. Hee Sung Chung, Young Min Kwon, and Victor C. Yang. Protein Transduction Domain-Mediated
Uptake of L-Asparaginase into Red Blood Cells. AAPS Journal (Supplement), San Antonio, Texas,
October 29 - November 2, 2006.
140. Cheol Moon, Won Kyu Lee, Young Min Kwon, and Victor C. Yang. Anti-Cancer Drug Carrier
System Based on Polyrotaxane-Drug Conjugate for Potential Tumor Therapy. AAPS Journal
(Supplement), San Antonio, Texas, October 29 - November 2, 2006.
141. Beata Chertok, Brad Moffat, Allan David, and Victor C. Yang. Magnetic Nanoparticles for Possible
Simultaneous MR Imaging and Drug Therapy of Brain Tumors. AAPS Journal (Supplement), San
Antonio, Texas, October 29 - November 2, 2006.
142. Victor C. Yang. Delivery of Macromolecular Drugs. The 282th Xiang Shang Scientific Meeting (香
山科学会议), pp14-15, Xiang Shan, China, August 28-31, 2006.
143. Victor C. Yang. Delivery of Macromolecular Drugs: From ATTEMPTS Approach to PTD-Mediated
Cellular Delivery. International Forum on Green Chemical Science & Engineering and Process
Systems Engineering, pp35-36, Tianjin, China, October 8-10, 2006.
144. Beata Chertok, Victor C. Yang, and Bradford Moffat. Magnetic Resonance Imaging of
magnetically targeted nanoparticles in an orthotopic 9L gliosarcoma brain tumor model.
Pharmaceutical Sciences: Bridging Research, Development and Regulation, University of Michigan,
Ann Arbor, Michigan, October 26-27, 2006.
145. Hee Sung Chung, Young Min Kwon, and Victor C. Yang. Protein Transduction Domain-Mediated
Uptake of L-Asparaginase into Red Blood Cells. Pharmaceutical Sciences: Bridging Research,
Development and Regulation, University of Michigan, Ann Arbor, Michigan, October 26-27, 2006.
146. Cheol Moon, Won Kyu Lee, Young Min Kwon, and Victor C. Yang. Anti-Cancer Drug Carrier
System Based on Polyrotaxane-Drug Conjugate for Potential Tumor Therapy. Pharmaceutical
Sciences: Bridging Research, Development and Regulation, University of Michigan, Ann Arbor,
Michigan, October 26-27, 2006.
33
147. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Delivery of Macromolecular Drugs: From
ATTEMPTS Approach to PTD-Mediated Cellular Delivery.
Proceedings of the 5th Asian
International Symposium on Biomaterials, pp 20, Xiamen, China, November 15-18 (2006).
148. Sun Ae Han, Yoon Sook Choi, Jin Sook Suh, Jue Yeon Lee, Chong Pyoung Chung, Victor C.
Yang, and Yoon Jeong Park. Intracellular Protein Delivery Using Cell Permeable Peptide
Regulates in vitro Mesencymal Stem Cell Differentiation. Proceedings of the 5th Asian International
Symposium on Biomaterials, pp 245, Xiamen, China, November 15-18 (2006).
149. Jun Sook Suh, Jung Min Kim, Jue Yeon Lee, Lami Kang, Young Min Kwon, Seung Jin Lee, Inho Jo,
Manho Kim, Victor C. Yang, and Yoon Jeong Park. Intracellular Magnetic Labeling of Stem Cells
Using Nontoxic Novel Membrane Translocating Peptide. Proceedings of the 5th Asian International
Symposium on Biomaterials, pp 256-257, Xiamen, China, November 15-18 (2006).
150. Jue Yeon Lee, Jung Eun Choo, Hyun Jung Park, Seung Jin Lee, Inho Jo, Chong Pyoung Chung,
Victor C. Yang, and Yoon Jeong Park. Synthetic Cell Binding Motif from Fibroblast Growth Factor
(FGF)-2 Can Induce Osteoblastic Differentiation of Human Bone Marrow Stromal Cells.
Proceedings of the 5th Asian International Symposium on Biomaterials, pp 262, Xiamen, China,
November 15-18 (2006).
151. Beata Chertok, Bradford A. Moffat, Allan David, and Victor C. Yang. Magnetic Nanoparticles as a
Possible Vehicle for MRI-Monitored Targeted Drug Delivery to Brain Tumors. Proceedings of the
13th International Symposium on Recent Advances in Drug Delivery Systems, pp 78-79, Salt Lake
City, Utah, February 26-28 (2007).
152. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Delivery Systems for Protein
Therapeutics. NEDO Special Lecture Series on DDS and Therapy, Tokyo Women’s Medical
University, Tokyo, Japan, October 13 (2007).
153. Victor C. Yang, Young Min Kwon, and Yoon Jeong Park. Strategies for Delivery of Protein
Therapeutics. The 1st Asian Biomaterials Congress (ABMC), Tsikuba, Japan, December 6-8 (2007).
154. Victor C. Yang. ATTEMPTS Approach for the Delivery of Macromolecular Drugs. AAPS Journal
(Supplement), San Diego, California, November 11-15 (2007).
155. Beata Chertok, Allan David, and Victor C. Yang. Magnetic Nanoparticles as a Drug Carrier: In
Vitro Drug Loading and Cytotoxic Evaluation. AAPS Journal (Supplement), San Diego, California,
November 11-15 (2007).
156. Shweta Urva, Cheol Moon, Young Min Kwon, Victor C. Yang, and Joseph Balthasar. EnzymeLinked Immunosorben Assay for Anti-Carcinoembryonic (CEA) IgG. AAPS Journal (Supplement),
San Diego, California, November 11-15 (2007).
157. Beata Chertok, Allan David, and Victor C. Yang. Glioma-Targeted Platform for Potential
Intracellular Drug Delivery: Design and Evaluation. Biomaterial Congress, Amsterdam, Netherland,
May 28 – June 1 (2008).
158. Beata Chertok, Allan David, Brad A. Moffat, Brian D. Ross and Victor C. Yang. MRI-guided
Targeting of Magnetic Nanoparticles in an Orthotopic 9L Gliosarcoma Brain Tumor Model. The
16th International Society for Magnetic Resonance in Medicine (ISMRM) Meeting, Toronto, Canada,
May 3-9 (2008).
159. Beata Chertok, Allan David, and Victor C. Yang. Delivery of Functional Proteins to Brain Tumor
Using MRI-Monitored, Magnetically Targeted Nanoparticles. The 10th European Symposium on
Controlled Drug Delivery, Noordwijk aan Zee, Netherland, April 2-4 (2008).
160. Beata Chertok, Allan David, and Victor C. Yang. Strategies for Enhanced Brain Tumor
Accumulation of Magnetic Nanoparticles for Potential Drug Delivery. Nanotech 2008, Boston, MA,
June 1-5 (2008).
161. Hee Sun Chung, Young Min Kwon, and Victor C. Yang. PTD-Mediated RBC Encapsulation of LAsparaginase for Potential Treatment of ALL: Pharmacokinetic and Efficacy Study. AAPS Journal
(Supplement), Atlanta, GA, November 16-19, 2008.
34
162. Tien Yi Lee, Roger Sunahara, James Woods, and Victor C. Yang. Red Blood Cell Encapsulated
Cocaine Esterase as a Novel Treatment Modality for Cocaine Intoxication. AAPS Journal
(Supplement), Atlanta, GA, November 16-19, 2008.
163. Young Min Kwon, Hee Sun Chung, Cheol Moon, Yoon Jeong Park, and Victor C. Yang. RBCEncapsulated Asparaginase for Enhanced Anti-leukemia Treatment. Korean Controlled Release
Society Annual Meeting, Jeju Island, Korea, September 4-5, 2008.
164. Tien Yi Lee, Yoon Shin Park, and Victor C. Yang. A Non-Disruptive Encapsulation of Cocaine
Esterase into Red Blood Cells by Cell Penetrating Peptides. AAPS Journal (Supplement), Los
Angeles, CA, November 16-20, 2009.
165. Yoon Shin Park, Yongzhuo Huang, Yoon Jeong Park, Allan David, Hee Sun Chung, and Victor C.
Yang. LMWP as an Efficient AS-ODN Carrier: Enhanced Delivery of AS-H1F1a-ODN During
Adipocyte Differentiation in 3T3-L1 under Hypoxia. AAPS Journal (Supplement), Los Angeles, CA,
November 16-20, 2009.
166. Yongzhuo Huang, Meong Cheol Shin, and Victor C. Yang. Cell-Penetrating Peptide Enables
Nose-to-Brain Delivery of Macromolecules. AAPS Journal (Supplement), Los Angeles, CA,
November 16-20, 2009.
167. Jun Beom Park, Young Min Kwon, Tien Yi Lee, and Victor C. Yang. PEGylation of Bacterial
Cocaine Esterase to Improve Protection against Protease Digestion and Reduce Immunogenicity.
AAPS Journal (Supplement), Los Angeles, CA, November 16-20, 2009.
168. Hee Sun Chung, Young Min Kwon, Allan David, and Victor C. Yang. In Vitro Properties of LMWPAsparaginase. AAPS Journal (Supplement), Los Angeles, CA, November 16-20, 2009.
169. Beata Chertok, Adam J. Cole, Allan E. David AE, and Victor C. Yang. Comparison of Electron
Spin Resonance Spectroscopy and Inductively Coupled Plasma Optical Emission Spectroscopy for
Biodistribution Analysis of Iron-Oxide Nanoparticles. AAPS Journal (Supplement), Los Angeles, CA,
November 16-20, 2009.
170. Faquan Yu, Lei Zhang, Kai Sun, Allan E. David, Beata Chertok, and Victor C. Yang. SelfAssembled Iron Oxide Core for the Synthesis of an Intrinsic Quick-Magnetophoretic Core-Shell
Superparamagnetic Nanoparticles and Their In Vitro Studies. Third International Symposium on
Industrial Crystallization and Drug Delivery Systems, Tianjin, China, September 5-8, 2009.
171. Beata Chertok, Faquan Yu, Allan David, and Victor C. Yang. MRI-Guided Magnetic Targeting and
Therapy of Brain Tumors. The 8th International Symposium on Frontiers in Biomedical Polymers,
Mishima. Japan, May 20-23, 2009.
172. Beata Chertok, Faquan Yu, Allan David, and Victor C. Yang. MRI-Guided Magnetic Targeting and
Therapy of Brain Tumors. The 4th International Pharmaceutical Symposium, Shanghai, China,
September 24-27, 2009.
173. Beata Chertok, Faquan Yu, Allan David, and Victor C. Yang. Synchronized MRI and Drug Therapy
for Brain Tumor Treatment. The 7th International Symposium for Chinese Medicinal Chemistry,
Kaoshiung, Taiwan, February 1-5, 2010.
174. Yoon Shin Park, Yongzhuo Huang, Hee Sun Chung, Lindsay A. White, Allan E. David, and Victor
C. Yang. Novel Obesity Therapy with Cell Permeable AS-HIF1-ODN. AAPS Journal
(Supplement), New Orleans, LA, November 14-18, 2010.
175. Lindsay White, Yoon Shin Park, and Victor C. Yang. Antibody Targeted Delivery of siRNA for
Colorectal Cancer Therapy: Synthesis of Delivery System Components. AAPS Journal
(Supplement), New Orleans, LA, November 14-18, 2010.
176. Beata Chertok, Faquan Yu, Allan David, and Victor C. Yang. MRI-Guided Pharmacological
Intervention of Brain Tumors. Symposium on Innovative Polymers for Controlled Delivery (SIPCD),
pp14, Su Zhou, China, September 14-17, 2010.
177. Beata Chertok, Faquan Yu, Allan David, and Victor C. Yang. A MR-Imaged, Clinically Enabled
Pharmacological Treatment of Brain Tumors. International Scholar Network Symposium on
Advanced Materials at Korean Polymer Society, Daegu, Korea, October 7, 2010.
35
178. Adam J. Cole, Jianxin Wang, Allan E. David AE, Craig J. Galban, and Victor C. Yang. Enhancing
Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. FIP World Congress Student
Meeting, New Orleans, LA, July, 2010.
179. Adam J. Cole, Jianxin Wang, Allan E. David AE, Craig J. Galban, and Victor C. Yang. Enhancing
Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. AAPS Annual Meeting, New Orleans,
LA, November 14-18, 2010.
180. Adam J. Cole, Jianxin Wang, Allan E. David AE, Craig J. Galban, and Victor C. Yang. Enhancing
Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. PGSRM Meeting, Columbus, OH,
November, 2010.
181. Mohammad S. Absar, Suna Choi, Victor C. Yang, and Young M Kwon. Heparin-Triggered
Release of Tissue Plasminogen Activator for Targeted Thrombolysis. Controlled Release Society
Annual Meeting, July 30-August 3, 2011, Baltimore, MD.
182. Victor C. Yang. MRI-Guided Pharmacological Intervention of Brain Tumors. International
Symposium on Intelligent Drug Delivery System, pp 19, April 28-29, 2011, Seoul, Korea.
183. Victor C. Yang. MR-Imaged Targeted Protein Delivery for Treatment of Brain Tumors”.
Proceedings of the 3rd Asian Biomaterials Congress, September 15-17, 2011, Busan, Korea.
184. Victor C. Yang. “Significance and Strategies in Developing Innovative Drug Delivery Systems.
International High-End Forum on Green Chemical Science & Engineering, September 22, 2011,
Tianjin, China.
185. Victor C. Yang. Significance and Strategies in Developing Innovative Drug Delivery Systems for
Macromolecular Drugs. Chong Kun Dang Pharmaceutical Corp., October 25, 2011, Seoul, Korea.
186. Victor C. Yang. Developing Innovative Drug Delivery Systems (DDS): Significance and Strategies.
World Class University (WCU) Distinguished Lecture Series, Seoul National University, October 26,
2011, Seoul, Korea.
187. Yoon Shin Park, Chia Yin Lin, and Victor C. Yang. Controlled Delivery of Simvastatin Found to
Help Regenerate Bone In Vitro. AAPS Annual Meeting, Washington DC, November 14-18, 2011.
188. Victor C. Yang. Magnetic Nanoparticles for Synchronized MRI and Drug Therapy of Brain Tumors.
Proceedings of the5th IEEE International Conference on Nano/Molecular Medicine and Engineering.
November 9-12, 2011, Jeju Island, Korea.
189. Than KD, Rahman SU, Kwake KA, Wang L, Than TT, Khan A, Park YS, Park KD, Yang VC, La
Marca F, Park P, Zhang H, and Lin CY. Intradiscal Injection of Simvastatin for Disc Regeneration in
a Rat Model of Degenerative Disc Disease. American Association of Neurological Surgeons
/Congress of NeurologicalSurgeons Annual Meeting, Orlando, FL, March 7-10, 2012.
190. Victor C Yang. Strategies in Developing Innovative Drug Delivery Systems. Abstract of the 2012
International Symposium of the Intelligent Drug Delivery System, pp. 41, Seoul, Korea, March 1416, 2012.
191. Victor C Yang. Strategies and Significance in Developing Innovative Drug Delivery Systems for
Macromolecular Drugs. Abstract of the The 3rd International Symposium on Edible Plant Resources
and the Bioactive Ingredients (ISEPR2012), Urumqi, Xingjiang, China, July 28-31, 2012.
192. Victor C Yang. Strategies and Significance in Developing Innovative Drug Delivery Systems for
Macromolecular Drugs. Abstract of the 2012 Chinese Pharmaceutical Conference, Chengdu
Sichuan University, China, September 20-21, 2012.
PRESENTATIONS
1.
2.
"Isolation of Nucleation Fraction of Microtubules." Meeting-in Miniature of the American Chemical
Society, North Texas State University, Denton, Texas (1976).
"Polymerization Studies of Tubulin." South Regional Meting of the American Chemical Society,
Dallas-Fort Worth, Texas (1977).
36
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
“Physical Properties of the Liponucleotides, A Phospholipid Derivative." American Cyanamide
Company, Clifton New Jersey, July (1982).
"Purification and Characterization of Heparinase." FASEB Annual Meeting, St. Louis, Missouri,
April (1984).
"How Can the Anticoagulant Activity of the Low Molecular Weight Heparin Fragments Be
Successfully Neutralized?" Genzyme Corporation, Boston, Massachusetts, November (1984).
"A Reactor for Removing Heparin at the Termination of Extracorporeal Therapy." 189th National
Meeting of the American Chemical Society, Miami Beach, Florida, April (1985).
"A New Approach for Anticoagulation Control." College of Pharmacy, The Ohio State University,
Columbus, Ohio, May (1985).
"Strategies for Large Scale Protein Purification." The Procter & Gamble Company, Cincinnati,
Ohio, June (1985).
"The pH-Dependent Binding Analysis: A Facile Approach for the Development of Strategies for
Large Scale Protein Purification." CIBA-GEIGY Corporation, Summit, New Jersey, July (1986).
"An Immobilized Enzyme Reactor for Extracorporeal Deheparinization."
The 3rd Tutzing
Symposium on Chemical Engineering in Medicine, Munich, West Germany, September (1985).
"The Development of a Heparinase Reactor." The First International Symposium on Immobilized
Enzymes and Cells, Waterloo, Ontario, Canada, June (1986).
"New Aspects in Extracorporeal Blood Detoxification: A System for Heparin Removal." The Fifth
University of Michigan College of Pharmacy Pharmaceutics Seminar, Ann Arbor, Michigan,
September (1986).
"Large Scale Production of Catalytically Pure Heparinase." American Institute of Chemical
Engineers Annual Meeting, Miami Beach, Florida, November (1986).
"A Novel Approach for Diminishing Potential Bleeding Risks Associated with the Use of Low
Molecular Weight Heparins (LMWH) in Extracorporeal Therapy." The 33rd Annual Meeting of
American Society for Artificial and Internal Organs, New York City, May (1987).
"Immobilized Heparinase: Recent Advent for Anticoagulation Control." Armstrong World Industries,
Lancaster, Pennsylvania, May (1987).
"New Approach for Anticoagulation Control." Clotters' Club, Red Cross Blood Center, Detroit,
Michigan, September (1987).
"Heparinase Immobilization: Optimization and Characterization." Enzyme Engineering Conference
IX, Santa Barbara, California, October (1987).
"Immobilized Enzymes and Their Applications." Army Research Workshop, Natick, Massachusetts,
April (1988).
"A Protamine Filter for Extracorporeal Blood Heparin Removal." 34th Annual Meeting of the
American Society for Artificial and Internal Organs, Reno, Nevada, May (1988).
"A Protein-Bound Polymeric Filter for Extracorporeal Blood Deheparinization." The 195th National
Meeting of the American Chemical Society, Toronto, Canada, June (1988).
"An Immobilized Protamine System for Removing Heparin in Extracorporeal Blood Circulation."
Annual Meeting of the American Association of Pharmaceutical Scientists, Orlando, Florida,
October (1988).
"Preparation and Characterization of Reactive Polymers." Army Research Office Working Group
Meeting, Rougemont, North Carolina, March 19-22 (1989).
"A Filter Device for the Prevention of Both Heparin and Protamine Induced Complications
Associated with Extracorporeal Therapy." The 24th Annual Meeting of the American Association for
the Advancement of Medical Instrumentation, St. Louis, Missouri, May 13-17 (1989).
"A Simple and Rapid Protamine Titration Method." The 24th Annual Meeting of the American
Association for the Advancement of Medical Instrumentation, St. Louis, Missouri, May 13-17 (1989)
37
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
"An Approach for the Prevention of Complications Associated with Extracorporeal Blood
Circulation." Annual Meeting of the American Society of Artificial Internal Organs, Dallas, Texas,
May 22-25 (1989).
"A Colorimetric Method for Rapid Determination of the Protamine Dose Required for Heparin
Removal." Annual Meeting of the American Society of Artificial Internal Organs, Dallas, Texas,
May 22-25 (1989).
"Phospholipid Derivatives: A Possible Means for Controlled Delivery of Nucleoside Drugs." The 16th
International Symposium on Controlled Release of Bioactive Materials, Chicago, Illinois, August 6-9
(1989).
"Strategy Development Regarding Large Scale Protein Purification." The 2nd International
Conference on Separation Science & Technology, Hamilton, Ontario, Canada, October 1-4 (1989).
"Immobilized Protamine: An Approach for the Control of Complications Associated with
Extracorporeal Therapy." Annual AlChE Meeting, San Francisco, California, November 5-10
(1989).
"Protamine Filter: A Novel Approach for the Control of Complications of Heparin Therapy." The
11th International Conference of the IEEE Engineering in Medicine and Biology Society, Seattle,
Washington, November 9-12 (1989).
"Ion-Exchange Hollow Fibers." The 199th National Meeting of the American Chemical Society,
Boston, Massachusetts, April 22-25 (1990).
"A Rapid and Precise Whole Blood Protamine Titration." Annual Meeting of the American Society
of Artificial Internal Organs, Washington DC, April 25-27 (1990).
"Biopolymer Coupled with Heparin Antidote for In Vivo Heparin Removal." The 200th Meeting of the
American Chemical Society, Washington DC, August 27-31 (1990).
"An Unconventional Approach of Utilizing Protamine: The Heparin Antidote." The 19th Annual
Meeting of the American Association of Pharmaceutical Scientists, Las Vegas, Nevada, November
5-9 (1990).
"Protamine Filter: An Approach to Prevent Heparin-Induced Hemorrhage and Protamine-Induced
Toxicity." The second Annual D.T.B. Grantee and Contractors Meeting entitled "Cardiovascular
Science and Technology: Basic and Applied II", Louisville, Kentucky, November 30 - December 2
(1990).
"A Protamine-Mediated Heparin Sensing Device." Annual Meeting of the American Society of
Artificial Internal Organs, Chicago, Illinois, April 25-27 (1991).
"Protamine-Coated Cuprophan: A Potential Non-Thrombogenic Hemodialysis Membrane with
Improved Blood Compatibility." Annual Meeting of the American Society of Artificial Internal
Organs, Chicago, Illinois, April 25-27 (1991).
"A Complete System for Anticoagulation Control." Cardiopulmonary Surgery Research Division,
Thoraxcentrum, University Hospital of Groningen, The Netherlands, July 12 (1991).
"A System for Anticoagulation Control: Current Development and Future Endeavor", CCCD and
Department of Pharmaceutics, The University of Utah, Salt Lake City, Utah, October 22 (1991).
"Biopolymers for Heparin Removal and Monitoring." The 203rd Annual Meeting of the American
Chemical Society, San Francisco, CA, April 6-10 (1992).
"A Novel Electrochemical Heparin Sensor", The 21st Annual Meeting of the American Association
of Pharmaceutical Scientists, San Antonio, Texas, November 14-19 (1992).
"A System for Heparin Removal and Monitoring", Cardiovascular Sciences and Technology
Conference, Washington, DC, December 12-14 (1992).
"A Novel Electrochemical Heparin Sensor", Annual Meeting of the American Society of Artificial
Internal Organs, New Orleans, Louisiana, April 29 - May 2 (1993).
"A Means to Improve the Biocompatibility of Cellulosic Dialyzer Membranes", Annual Meeting of the
American Society of Artificial Internal Organs, New Orleans, Louisiana, April 29 - May 2 (1993).
38
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59
60.
61.
62.
63.
64.
65.
"A Novel Electrochemical Sensor for Direct Monitoring of Heparin in Clinical Whole Blood
Specimens." National Meeting of the American Association for Clinical Chemistry, New York City,
New York, July 11-14 (1993).
"Electrochemical Sensor for Heparin: Development, Characterization, and Biomedical
Applications." Science Innovation '93, Boston, Massachusetts, August 6-10 (1993).
"A Novel Electrochemical Sensor for Heparin." The Fourth IBC International Symposium on
Anticoagulant, Antithrombotic, and Thrombolytic, Boston, MA, September 27-29 (1993).
"Sensor-Controlled, Polymer-Based Bio-Feedback System for Heparin Removal", POLYMED'93,
Chicago, Illinois, October 12-14 (1993).
"A Sensor-Directed Heparin Removal System." School of Pharmacy, Purdue University, November
9 (1993).
"Biocompatibility of the Protamine-Coated Cellulosic Dialyzer Membranes." Annual Meeting of the
American Society of Artificial Internal Organs, San Francisco, CA, April 14-16 (1994).
"A Disposable Coated-Wire Heparin Sensor." Annual Meeting of the American Society of Artificial
Internal Organs, San Francisco, CA, April 14-16 (1994).
"Protamine and Heparin Biosensors." Annual Meeting of the American Society of Artificial Internal
Organs, San Francisco, CA, April 14-16 (1994).
"A Sensor-Directed Bio-Feedback Heparin Removal System." American Chemical Society Central
and Great Lakes Regional Meeting, Ann Arbor, Michigan, May 31- June 3 (1994).
"A Novel Electrochemical Heparin Sensor." The 21st International Symposium on Controlled
Release of Bioactive Materials, Nice, France, June 24-30 (1994).
"A Bio-Feedback Drug Removal System." The 21st International Symposium on Controlled
Release of Bioactive Materials, Nice, France, June 24-30 (1994).
"A Protamine Filter for Extracorporeal Heparin Removal: Development, Blood Compatibility
Evaluation, and Future Direction." Annual Meeting of the American Society of Artificial Internal
Organs, Chicago, IL, May 4-6 (1995).
"Clinical Application of Disposable Heparin Sensors: Blood Heparin Measurements during Open
Heart Surgery." Annual Meeting of the American Society of Artificial Internal Organs, Chicago, IL,
May 4-6 (1995).
“Heparin Sensing.” Invited Lecture in the Annual Meeting of the American Society of Artificial
Internal Organs, Chicago, IL, May 4-6 (1995).
“Modern Approaches in Monitoring, Removal, and Delivery of Drugs.” Invited seminar at the
Chemistry Department, TamKang University, Taipei, Taiwan, on November 13 (1995).
“A Sensor-Directed Biofeedback Heparin Removal System.” Invited seminar at the Department of
Biomedical Engineering, National Taiwan University Medical Center, Taipei, Taiwan, on November
14 (1995).
“A Novel Electrochemical Heparin Sensor.” Invited lecture in the Xth World Congress of the
International Society for Artificial Organs, Taipei, Taiwan, November 15 (1995).
“A Protamine Filter for the Prevention of Both Heparin- and Protamine-Induced Complications
During Extracorporeal Blood Circulation.” Invited lecture in the Xth World Congress of the
International Society for Artificial Organs, Taipei, Taiwan, November 16 (1995).
“Heparin Sensing and Removal.” Invited seminar at the China Pharmaceutical University, Nanjing,
China, on November 20 (1995).
“Cutting Edge Pharmaceutical Sciences: Application of Modern Biotechnology on Drug Monitoring,
Removal, and Delivery.” Keynote speech on the Chinese National Pharmaceutics Congress,
Nanjing, China, November 21 (1995).
“Optimization and Assessment of the In Vivo Efficacy of a Heparin-Removing Bio-Reactor Using
Mathematical Modeling.” Annual Meeting of the American Society of Artificial Internal Organs,
Washington DC, May 1-4 (1996).
39
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
“Heparin and Protamine Biosensors: Development and Applications.” Center for Controlled
Chemical Delivery (CCCD) and Department of Pharmaceutics, The University of Utah, Salt Lake
City, UT, May 17 (1996).
“A Novel Electrochemical Heparin Sensor: Principles and Practice.” Invited lecture in the 2nd
Medical Engineering Week of the World (2’MEWW), Taipei, Taiwan, May 26-30 (1996).
“A Protamine Bio-reactor for Extracorporeal Heparin Removal: Development, In Vitro Modeling,
and In Vivo Testing.” Invited lecture in the 2nd Medical Engineering Week of the World
(2’MEWW), Taipei, Taiwan, May 26-30 (1996).
“A Sensor-Directed Biofeedback System for Extracorporeal Heparin Removal.” Invited lecture at
the Institute of Biomedical Engineering, The National Yang-Ming University, Taipei, Taiwan, May 24
(1996).
“Heparin Monitoring and Removal.” Invited seminar at the College of Pharmacy, The National
Defense Medical Center (NDMC), Taipei, Taiwan, May 31 (1996).
“A Sensor-Directed Biofeedback System for Extracorporeal Heparin Removal.” University of
Michigan Biomedical Engineering Symposium (BME 500), Ann Arbor, Michigan, November 13
(1996).
“In Vitro and Extracorporeal Blood Heparin Removal Utilizing a Protamine Filter Device.”
GelmanSciences, Ann Arbor, Michigan, November 14 (1996).
“Biosensors and Their Applications.” Invited Key Lecturer in the 1997 American Society of Artificial
Internal Organs (ASAIO) Annual Meeting, Atlanta, Georgia, May 1-3 (1997).
“Current Advances in Drug Delivery Systems.” Invited speaker in the First Asian International
Symposium on Polymeric Biomaterial Sciences, Ishikawa, Japan, May 14-17 (1997).
“Target and Triggered Drug Delivery Systems.” Invited lecture at the College of Pharmacy, the
National Defense Medical Center, Taipei, Taiwan, July 28 (199).
“A Bio-Feedback Drug Removal System.” Invited lecture at the Department of Anesthesiology,
National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, July 29 (1997).
“Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Invited lecture at the
College of Pharmacy, Taipei Medical University, Taipei, Taiwan, July 29 (1997).
“Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Invited lecture at the
Kwangju Institute of Science and Technology (KJIST), Kwangju, Korea, August 4 (1997).
“Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Invited lecture at the
Korea Institute of Science and Technology (KIST), Seoul, Korea, August 5 (1997).
“A Bio-Feedback Drug Removal System.” Invited lecture at the Johnson & Johnson Drug Delivery
Symposium, Princeton Hyatt Regency, Princeton, NJ, September 29 (1997).
“A Bio-Feedback Drug Removal System.” Invited lecture at the Department of Biomedical
Engineering, The University of Pittsburgh, Pittsburgh, PA, October 10 (1997).
“A Sensor-Directed Biofeedback System for Extracorporeal Heparin Removal.” Invited lecture at
the Chemistry Department, Brown University, Providence, Rhode Island, November 7 (1997).
“A Biofeedback Drug Removal System.” Lecture I of the “University Lectureship” given by
Tamkang University, Taipei, Taiwan, December 8 (1997).
“Target and Local Release of Active Thrombolytic Agents.” Lecture II of the “University Lectureship”
given by Tamkang University, Taipei, Taiwan, December 9 (1997).
“Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Lecture III of the
“University Lectureship” given by Tamkang University, Taipei, Taiwan, December 10 (1997).
“Systems for Drug Removal and Delivery.” Invited lecture at the Union Chemical Laboratories,
Taipei, Taiwan, December 15 (1997).
“A Sensor-Directed Biofeedback System for Extracorporeal Heparin Removal.” Invited seminar at
the Department of Biomedical Engineering, The University of Florida, Geinsville, Florida, March 17
(1998).
40
88.
89.
90.
91.
92.
93.
94.
95.
96.
97.
98.
99.
100.
101.
102.
103.
104.
105.
106.
107.
“Novel Approach for Optimizing the Capacity and Efficacy of a Protamine Filter for Clinical
Extracorporeal Heparin Removal.” Annual Meeting of the American Society of Artificial Internal
Organs, New York City, New York, April 22-25 (1998).
“A Delivery System for Targeted Thrombolysis without the Risk of Hemorrhage.” Annual Meeting of
the American Society of Artificial Internal Organs, New York City, New York, April 22-25 (1998).
“Polypeptides as Drug Carriers: From Diffusion Controlled Systems to Hydrogels.” The 1998 Union
Chemical Laboratories (UCL) Technical Advisory Meeting on Biotechnology and Pharmaceuticals,
Hsinchu, Taiwan, May 21-23 (1998).
“Polypeptide-Based Drug Delivery Systems: From Diffusion Controlled Carriers to Hydrogels.” The
Ninth Japanese-American Conference on Pharmacokinetics and Biopharmaceutics, Nagoya,
Japan, July 29-31 (1998).
“Approaches for Triggered and Local Release of Active Thrombolytic Agents.” Fujisawa Co.,
Osaka, Japan, July 29 (1998).
“Approaches for Triggered and Local Release of Active Thrombolytic Agents.” Symposium of
Biomaterials and Controlled Release Society of Taiwan, Taipei, Taiwan, August 5 (1998).
“A Sensor-Directed Biofeedback System for Extracorporeal Heparin Removal.” National Tsing Hua
University, Hsinchu, Taiwan, August 6 (1998).
“Heparin and Protamine Biosensors: Principles and Biomedical Applications.” WorldPharm98,
Philadelphia, Pennsylvania, September 23 (1998).
“Approaches for Triggered and Local Delivery of Thrombolytic Agents.” Drexel University,
Philadelphia, Pennsylvania, September 24 (1998).
“The Use of “ATTEMPTS” Approach for Delivery of Enzyme Drugs.” SmithKline Beecham
Pharmaceuticals, Collegeville, Pennsylvania, September 25 (1998).
“The Use of “ATTEMPTS” Approach for Delivery of Catalytic Drugs Without Associated Toxic
Effects.” The 18th Pharmaceutical Technology Conference, Utrecht, The Netherlands, April 14-15
(1999).
“ATTEMPTS: A Novel Approach for Delivery of Enzyme Drugs.” Department of Pharmaceutics,
College of Pharmacy, The University of Utah, Salt Lake City, Utah, May 10 (1999).
“A Novel Recombinant Approach for Targeted Thrombolysis without the Risk of Bleeding.” Annual
Meeting of the American Society of Artificial Internal Organs, San Diego, California, June 2-5
(1999).
“Low Molecular Weight Protamine: A Potent but Non-Toxic Antagonist to Heparin/LMWH.” Annual
Meeting of the American Society of Artificial Internal Organs, San Diego, California, June 2-5
(1999).
“Heparin/Protamine Biosensors: Principle and Biomedical Applications.”
Department of
Pharmaceutical Chemistry and Biotechnology Center, University of Kansas, Lowrence, Kansas,
June 15 (1999).
“A Novel Approach, ATTEMPTS, for Delivery of Thrombolytic Drugs without Associated Toxic
Effects.” Department of Pharmaceutics, Ohio State University, Columbus, Ohio, October 4 (1999).
“ATTEMPTS: A Novel Approach for Delivery of Enzyme Drugs without Associated Toxic Effects.”
The Global Chinese Symposium on Biomaterials and Controlled Release, October 26-28 (1999).
“Current Advances in Anticoagulation Control.” Tamkang Chair Lectureship (I), Tamkang
University, Taipei, Taiwan, November 15 (1999).
“Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Tamkang Chair
Lectureship (II), Tamkang University, Taipei, Taiwan, November 16 (1999).
“ATTEMPTS: A Novel Approach for Delivery of Enzyme Drugs without Associated Toxic Effects.”
Tamkang Chair Lectureship (III), Tamkang University, Taipei, Taiwan, November 17 (1999).
41
108. “ATTEMPTS: A Novel Approach for Delivery of Enzyme Drugs without Associated Toxic Effects.”
Department of Clinical Pharmacy, National Cheng Kung University, Tainan, Taiwan, November 19
(1999).
109. “ATTEMPTS: A Heparin/Protamine-Based Prodrug Delivery System.” Sixth European Symposium
on Controlled Drug Delivery, Noordwijk Ann Zee, The Netherlands, April 12-14 (2000).
110. “ATTEMPTS: A New Approach for Delivery of Protease Drugs.” Division of Pharmaceutical
Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, April 21
(2000).
111. “The Use of ATTEMPTS for Targeted and Triggered Delivery of Thrombolytic Drugs.” International
Symposium on Biomaterials and Drug Delivery Systems, Cheju Island, Korea, August 20-22
(2000).
112. “Approaches for Delivery of Thrombolytic Drugs.” Homeostasis/Thrombosis Research Seminar,
University of Michigan Cardiovascular Center, Medical School, Ann Arbor, Michigan, September
(2000).
113. “Overview of Drug Delivery Systems.” The 1st Taipei Biotech Fair, Taipei, Taiwan, September 21
(2000).
114. “Approaches for Designing Novel Delivery Systems Using our “ATTMPTS” System for Delivery of
Enzyme Drugs as an Example.” The 1st Taipei Biotech Fair, Taipei, Taiwan, September 21 (2000).
115. ATTEMPTS: A Heparin/Protamine-Based Delivery System for Enzyme Drugs.”
The 10th
International Symposium on Recent Advances in D“rug Delivery Systems, Salt Lake City, Utah,
February 19 (2001).
116. “Heparin and Protamine Biosensors: Principles and Biomedical Applications.” Korean Analytical
Chemistry Society meeting, Seoul, Korea, March 10 (2001).
117. “Novel Approaches for Delivery of Enzymes.” Tokyo Women’s Medical University, Tokyo, Japan,
March 14 (2001).
118. “Novel Approaches for Heparin Anticoagulation Control.” Tokyo Women’s Medical University,
Tokyo, Japan, March 16 (2001).
119. “ATTEMPTS for Delivery of Enzyme Drugs.” Department of Pharmaceutics, SUNY-Buffalo,
Buffalo, New York, April 11 (2001).
120. “Advances in Anticoagulation Control: From External Heparin Removing System to the
Development of Non-Toxic Heparin Antagonist.” Department of Pharmaceutics, University of Utah,
Slat Lake City, Utah, May 16 (2001).
121. “Polypeptide-Based Carriers as Drug Delivery Platforms: From the Development of a DiffusionControlled Biodegradable System to pH-Sensitive Hydrogels.” School of Materials Sciences,
Japan Advance Institute of Science and Technology (JAIST), Ishikawa, Japan, June 14 (2001).
122. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” School of Materials Sciences (Prof.
Yui), Japan Advance Institute of Science and Technology (JAIST), Ishikawa, Japan, June 14
(2001).
123. “Polypeptide-Based Carriers as Drug Delivery Platforms: From the Development of a DiffusionControlled Biodegradable System to pH-Sensitive Hydrogels.” Department of Pharmaceutics (Prof.
Nagai), Hoshi University, Tokyo, Japan, June 18 (2001).
124. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” R&D Center, Terumo Corporation,
Kanagawa, Japan, June 19 (2001).
125. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” Pharmaceutical and Drug Delivery
Research Laboratories, Sankyo Co. LTD., Tokyo, Japan, June 25 (2001).
126. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” Department of Medical Research
and Education, Taipei Veterans General Hospital, Taipei, Taiwan, June 29 (2001).
127. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” School of Pharmacy, National
Taiwan University, Taipei, Taiwan, July 2 (2001).
42
128. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” Department of Pharmaceutics (Prof.
Sugiyama), University of Tokyo, Tokyo, Japan, July 9 (2001).
129. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” Department of Pharmaceutical
Sciences (Prof. Hashida), Kyoto University, Kyoto, Japan, July 16 (2001).
130. “A Bio-feedback System for Extracorporeal Heparin Removal.” Department of Chemical
Engineering (Prof. Sakai), Waseda University, Tokyo, Japan, July 18 (2001).
131. “Heparin and Protamine Biosensors: Principle and Biomedical Applications. (I)”, “ATTEMPTS: A
Novel System for Delivery of Enzyme Drugs. (II)” Department of Biomolecular Engineering (Prof.
Akaike), Tokyo Institute of Technology, Tokyo, Japan, July 19 (2001).
132. (I) “Heparin and Protamine Biosensors: Principle and Biomedical Applications.” (II) “ATTEMPTS: A
Novel System for Delivery of Enzyme Drugs – New Applications in Drug Therapy.” Department of
Biomedical Engineering (Prof. Okano), Tokyo Women’s Medical University, Tokyo, Japan, July 27
(2001).
133. “Polypeptide-Based Carriers as Drug Delivery Platforms: From the Development of a DiffusionControlled Biodegradable System to pH-Sensitive Hydrogels.” Nippon Oil and Fat Company,
Tokyo, Japan, July 30 (2001).
134. “Heparin and Protamine Biosensors: Principle and Biomedical Applications.” Department of
Biomaterial Sciences (Prof. Kataoka), University of Tokyo, Tokyo, Japan, July 31 (2001).
135. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” Tianjin Medical University, Tianjin,
China, Aug. 19 (2001).
136. “Heparin and Protamine: From Clinical Uses to the Development of their Removal System,
Biosensors, and Related Targeted Drug Delivery Approaches.” Tianjin University, Tianjin, China,
August 21 (2001).
137. “Heparin/Protamine-Based Systems for Biomedical Applications.” Department of Chemical
Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, September 26
(2001).
138. “Current Advances in the Development of the ATTEMPTS Approach in Delivering Enzyme Drugs.”
The Seventh Biomedical Materials & Technology Symposium, Taipei, Taiwan, December 8 (2001).
139. “Approaches in Drug Monitoring, Removal, and Delivery.” Department of Biomedical Engineering,
Taipei Medical University, Taipei, Taiwan, December 12 (2001).
140. “Pharmaceutical Engineering: Design of Delivery Systems for Catalytic, Macromolecular Drugs.”
National Health Research Institute (NHRI), Taipei, Taiwan, April 12 (2002).
141. “ATTEMPTS: A Heparin/Protamine Based Delivery System for Enzyme Drugs.” The Third Asian
International Symposium on Polymeric Biomaterials Science.” Taipei, Taiwan, April 14-16 (2002).
142. “A Bioreactor for Blood Heparin Removal.” Department of Chemical Engineering, National Taiwan
University of Science and Technology, Taipei, Taiwan, April 16 (2002).
143. “A Bioreactor for Blood Heparin Removal.” Department of Chemical Engineering, National Chung
Hsing University, Taichung, Taiwan, April 17 (2002).
144. “ATTEMPTS: A Pharmaceutical Engineering Approach for Delivery of Macromolecular Drugs.” The
First World Congress for Chinese Biomedical Engineers, Taipei, Taiwan, December 9-11 (2002).
145. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs Using Thrombolytic Agents as the
Drug Model.” USC-Division of Pulmonary & Critical Care Medicine Seminar Series. Los Angeles,
CA, April 25 (2003).
146. “Application of Biotechnology to the Development of Novel Drug Delivery Systems Using t-PA as
the Model Enzyme Drug.” AACP 2003 Paul Dawson Biotechnology Award presentation,
Minneapolis, MN, July 23 (2003).
147. “ATTEMPTS for Enzyme Delivery: Principle and Progressive Development” Department of
Pharmaceutics, School of Pharmacy, Rutgers University, Piscatway, NJ, September 9, 2003.
43
148. “Biomedical Engineering and Novel Drug Delivery Systems.” AAPS 2003 Research Achievement
Award in Biotechnology round-table award presentation, Salt Lake City, UT, October 28 (2003).
149. “ATTEMPTS for Drug Delivery” School of Pharmacy, Kaohsiung Medical University, Kaohsiung,
Taiwan, Nov. 18 (2003).
150. “Development of LMWP and Its Important Biomedical Applications.” Biomedical Engineering
Center, Industrial Technology Research Institute (ITRI), Hsinchu, Taiwan, November 18 (2003).
151. “ATTEMPTS for Drug Delivery.” School of Pharmacy, National Defense Medical Center (NDMC),
Taipei, Taiwan, November 18 (2003).
152. “ATTEMPTS for Drug Delivery.” School of Pharmacy, EHWA University, Seoul, Korea, November
26 (2003).
153. “ATTEMPTS for Drug Delivery.” Korean Society of Pharmaceutics Annual Meeting, Seoul, Korea,
November 27 (2003).
154. “Application of the “ATTEMPTS” for Drug Delivery.” Eighth European Symposium on Controlled
Drug Delivery, Noorwijk aan Zee, The Netherlands, April 7 (2004).
155. “ATTEMPTS: A Novel System for Delivery of Enzyme Drugs.” The 10th SCBA (Society of Chinese
Bioscientists in America) International Symposium, PP131-132, Beijing, China, July 18-23 (2004).
156. “Novel PTD-Mediated Protein Delivery System.” Tokyo Women’s Medical University, Tokyo,
Japan, July 29, 2004.
157. “Heparin: A Clinical Polysaccharide Drug and an Excipient in the Design of Drug Delivery System.”
The 228th American Chemical Society Meeting, Philadelphia, Pennsylvania, August 23 (2004).
158. “The “ATTEMPTS” Approach for Delivering Protein Drugs.” Department of Pharmacology &
Pharmaceutical Sciences, University of Houston, Houston, Texas, October 28 (2004).
159. “An Innovative PTD-Mediated Protein Delivery for Cancer Therapy.” The 4th Asian International
Symposium on Biomaterials and Drug Delivery Systems, Tsukuba, Japan, November 16-18 (2004).
160. “An Innovative PTD-Mediated Protein Delivery for Cancer Therapy.” Department of Molecular
Sciences and Technology, Ajou University, Suwon, Korea, November 19 (2004).
161. “The “ATTEMPTS” Approach for Delivering Protein Drugs.” Department of Pharmaceutical
Sciences, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, December
14 (2004).
162. “The ATTEMPTS Approach for Delivery of Macromolecular Drugs.” Department of Pharmaceutical
Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, January 19 (2005).
163 “A Novel PTD-Mediated Protein Delivery for Cancer Therapy.” Department of Pharmaceutical
Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada, April 1 (2005).
164. Cheung Kong Scholar Lecture Series - [I] “A Bioreactor Approach for Blood Detoxification.” School
of Chemical Engineering, Tianjin University, Tianjin, China, April 11, 2005.
165. Cheung Kong Scholar Lecture Series - [II] “Heparin and Protamine Bioreactor: Principle and
Biomedical Applications.” School of Chemical Engineering, Tianjin University, Tianjin, China, April
12, 2005.
166. Cheung Kong Scholar Lecture Series - [III] “Application of the ATTEMPTS for Drug Delivery.”
School of Chemical Engineering, Tianjin University, Tianjin, China, April 13 (2005).
167. Cheung Kong Scholar Lecture Series - [IV] “PTD-Mediated Cellular Delivery of Macromolecular
Drugs.” School of Chemical Engineering, Tianjin University, Tianjin, China, April 14 (2005).
168. “Application of the ATTEMPTS for Drug Delivery.” School of Pharmacy, China Pharmaceutical
University, Nanjing, China, April 18, 2005.
169. “Delivery of Macromolecular Drugs: From ATTEMPTS Approach to PTD-Mediated Cellular
Delivery.” Chinese 2005 National Meeting of Outstanding PhD Students in Chemical Engineering,
Tianjin, China, August 12-14 (2005).
44
170. “Application of Peptide in Biomedical Engineering and Drug Delivery.” 7 International Symposium
on Peptides and Biomaterials for Tissue Regeneration, Seoul, Korea, August 29 (2005).
171. “The ATTEMPTS Approach for Delivery of Macromolecular Drugs.” Institute of Life Sciences,
Science and Technology University of China, He-Fei, An Huei, China, May 11 (2006).
172. “The ATTEMPTS Approach for Delivery of Macromolecular Drugs.” China-Japan Symposium on
Pharmaceutical Preparations and Particulate Design, Shenyang, China, May14-17 (2006).
173. “Approach for Delivery of Macromolecular Drugs.” Shenyang Pharmaceutical University, Shenyang,
China, July 3rd (2006).
th
174. “Strategies for Developing Macromolecular Therapeutic Agents.” The 282th Xiang Shan Meeting,
Xiang Shan, China, August 29 (2006).
175. “Delivery of Macromolecular Drugs.” The 282th Xiang Shang Scientific Meeting (香山科学会议),
Xiang Shan, China, August 28-31 (2006).
176. “Delivery of Macromolecular Drugs: From ATTEMPTS Approach to PTD-Mediated Cellular
Delivery.” International Forum on Green Chemical Science & Engineering and Process Systems
Engineering, Tianjin, China, October 9 (2006).
177. “ATTEMPTS System for the Delivery of Macromolecular Drugs.” Department of Pharmaceutical
Sciences, Wayne State University, Detroit, Michigan, November 8, 2006.
178. “Delivery of Protein Drugs.” The 5th Asian International Symposium on Biomaterials, Xiamen,
China, November 15-18 (2006).
179. “Delivery of Macromolecular Drugs.” School of Pharmacy, Seoul National University, Seoul, Korea,
March 16, (2007).
180. “Strategies for Designing Delivery Systems for Macromolecular Drugs.” The 3rd WACBE World
Congress in Biomedical Engineering, Bangkok, Thailand, July 9-11 (2007).
181. “Delivery Systems for Protein Therapeutics.” NEDO Special Lecture Series on DDS and Therapy,
Tokyo Women’s Medical University, Tokyo, Japan, October 13 (2007).
182. “Synchronized MRI and Drug Therapy for Pediatric Brain Tumors.” Institute of Biomedical
Engineering, Tokyo Women’s Medical University, Tokyo, Japan, October 16 (2007).
183. “Delivery Systems for Protein Therapeutics.” The 3rd International Pharmaceutical Symposium:
Novel Drug Delivery Systems: Research and Applications, Shanghai, China, October 19-21 (2007).
184. “Strategies for Delivering Protein Therapeutics.” Department of Pharmaceutical Sciences, St. John
University, New York, NY, November 8 (2007).
185. “ATTEMPTS for Delivery of Macromolecular Drugs.” Invited lecture for the Workshop on “Prodrug
Approaches for Site-Specific Cellular Targets”, AAPS Annual Meeting, San Diego, California,
November 11-15, 2007.
186. “Targeted Therapy for Brain Tumors Using Magnetic Iron Nanoparticles.” Neuro-oncology
Conference, Department of Neurosurgery, University of Michigan Medical School, January 7, 2008.
187. “Strategies for Delivery of Protein Therapeutics.” The Kenneth E. Avis Distinguished Visiting
Professorship in Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee
Health Science Center, Memphis, TN, March 24-25, 2008.
188. “Strategies for Delivery of Protein Therapeutics.” University Lectureship, Nankai University, Tianjin,
China, July 17, 2008.
189. “Encapsulated Asparaginase for Enhanced Anti-leukemia Treatment.” Korean Controlled Release
Society Annual Meeting, Jeju Island, Korea, September 4-5, 2008.
190. “MRI-Guided Magnetic Targeting and Therapy of Brain Tumors.” 8th International Symposium on
Frontiers in Biomedical Polymers, Mishima. Japan, May 20-23, 2009.
191. “Strategies to Improve Asparaginase Therapy in ALL Treatment.” Hematological Malignancies
Program, St. Jude Children Hospital, Memphis, TN, June 3, 2009.
45
192. “MRI-Guided Magnetic Targeting and Therapy of Brain Tumors.” Department of Molecular Medicine
and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea, July 16, 2009.
193. “MRI-Guided Magnetic Targeting and Therapy of Brain Tumors.” 4th International Pharmaceutical
Symposium, Shanghai, China, September 24-27, 2009.
194. “Synchronized MRI and Drug Therapy for Brain Tumor Treatment.” ISCMC (The 7th International
Symposium for Chinese Medicinal Chemistry), Kaoshiung, Taiwan, February 1-5, 2010.
195. “MRI-Guided Pharmacological Intervention of Brain Tumors.” Symposium on Innovative Polymers
for Controlled Delivery (SIPCD), pp14, Su Zhou, China, September 14-17, 2010.
196. “A MR-Imaged, Clinically Enabled Pharmacological Treatment of Brain Tumors.” International
Scholar Network Symposium on Advanced Materials at Korean Polymer Society, Daegu, Korea,
October 7, 2010.
197. “Magnetic Iron Oxide Nanoparticle (MION)-Basede Nanotechnology for Concomitant Brain Tumor
MRI and Drug Therapy”. Korean Society of Biomaterials (KSBM) annual meeting, Seoul National
University Hospital, Seoul, Korea, November 25-26, 2010.
198. “Applications of Cell-Penetrating Peptides in Drug Delivery for Cancer Treatment”. 50th Anniversary
of International Congress of the Korean Academy of Periodontology (ICKAP), Seoul, Korea,
November 27-28, 2010.
199. “MRI-Guided Pharmacological Intervention of Brain Tumors”. International Symposium on
Intelligent Drug Delivery System, April 28-29, 2011, Seoul, Korea.
200. “Nasal Delivery of Neurotrophic Factors to the Brain for the Treatment of Parkinson Disease”. CHDI
Workshop on Delivering Neuroprotective Agents to the Brain, June 1-2, 2011, New York, NY.
201. “Selective Protein Delivery for Treatment of Brain Tumors”. Utah-Inha Joint Symposium and InhaClinic Symposium. June 10, 2011, Incheon, Korea.
202. “Nasal Delivery of Neurotrophic Factors to the Brain for the Treatment of Parkinson Disease”. The
Buck Institute for Research on Aging, July 15, 2011, Novato, CA.
203. “MR-Imaged Targeted Protein Delivery for Treatment of Brain Tumors”. The 3rd Asian Biomaterials
Congress, September 15-17, 2011, Busan, Korea.
204. “Singnificance and Strategies in Developing Innovative Drug Delivery Systems”. International
High-End Forum on Green Chemical Science & Engineering. September 22, 2011, Tianjin, China.
205. “Singnificance and Strategies in Developing Innovative Drug Delivery Systems for Macromolecular
Drugs”. Chong Kun Dang Pharmaceutical Corp., October 25, 2011, Seoul, Korea.
206. “Developing Innovative Drug Delivery Systems (DDS): Significance and Strategies”. World Class
University (WCU) Distinguished Lecture Series, Seoul National University, October 26, 2011, Seoul,
Korea.
207. “Magnetic Nanoparticles for Synchronized MRI and Drug Therapy of Brain Tumors”. The 5th IEEE
International Conference on Nano/Molecular Medicine and Engineering. November 9-12, 2011,
Jeju Island, Korea.
208. “Strategies in Developing Innovative Drug Delivery Systems”. International Symposium of the
Intelligent Drug Delivery System, March 14-16, 2012, Seoul, Korea.
209. “Strategies and Significance in Developing Innovative Drug Delivery Systems for Macromolecular
Drugs”. School of Pharmacy, Haerbin University, Haerbin, China, May 14, 2012.
210. Victor C Yang. Strategies and Significance in Developing Innovative Drug Delivery Systems for
Macromolecular Drugs. The 3rd International Symposium on Edible Plant Resources and the
Bioactive Ingredients (ISEPR2012), Urumqi, Xingjiang, China, July 28-31, 2012.
211. Victor C Yang. Strategies and Significance in Developing Innovative Drug Delivery Systems for
Macromolecular Drugs. 2012 Chinese Pharmaceutical Conference, Chengdu Sichuan University,
China, September 20-21, 2012.
46
STUDENTS/STAFF/POSTDOCTORALS TRAINED
(A) Current
* Ph.D. Students (2)
(1)
(2)
Mr. Meong Cheol Shin
Ms. Jinwen Zhao
* Postdoctoral Research Fellows (4)
(1)
(2)
(3)
(4)
Dr. Kyuri Lee
Dr. Jiang Zhang
Dr. Jie Zhou
Dr. Mei Wang
(B) Previous (Total: 79)
* Ph.D. Students (19)
(1)
Dr. Weiliam Chen
Thesis: A Non-Clotting and Non-Instrumental Method for Sensing Heparin and Monitoring of
Extracorporeal Anticoagulation (1991).
Current Status: Assistant Professor, Department of Biomedical Engineering, SUNY-Stony
Brook, NY.
(2)
Dr. Youyin Fu
Thesis:
The Effects of Protamine Coating on Blood Compatibility of Polymeric
Materials(1993).
Current Status: Not Available
(3)
Dr. Thomas Cook
Thesis: Synthesis and Release Characterization of Polypeptide for the Controlled Release
of Drugs (1995).
Current Status: Assistant Professor, School of Pharmacy, Rutgers University.
(4)
Dr. Peter Markland
Thesis: Modified Polypeptides and Polypeptide Hydrogels for Controlled Drug Delivery
(1998).
Current Status: Senior Scientist, Southern Research Institute, Birmingham, AL.
(5)
Dr. Ngoc-Anh Nguyen
Thesis: Intracellular Delivery of Antisense Oligodeoxynucleotides Utilizing Starburst
Polyamidoamine (PAMAM) Dentrimers as Carriers (2000).
Current Status: Senior Scientist, Amgen, Los Angeles, CA.
(6)
Dr. Tanya Wang
Thesis: Design of a Protamine Bioreactor for Extracorporeal Heparin Removal (2000).
Current Status: Regulatory Affairs Associate, AHFMR (Canadian FDA)., Edmonton, Alberta,
Canada.
(7)
Dr. Li-Chien Chang
Thesis: Protamine Modification and their New Biomedical Applications (2001).
Current Status: Associate Professor, School of Pharmacy, National Defense Medical
Center, Taipei, Taiwan.
(8)
Dr. Lai-Ming Lee
Thesis: Anticoagulant Neutralization with Low Molecular Weight Protamine and Monitoring
Using Polycation Sensitive Sensor (2003).
47
Current Status: Regulatory Associate, Food and Drug Administration, Rockville, MD.
(9)
Dr. Yongtao Li
Thesis: Strategies for Enhancing Enzyme Delivery Using the Heparin/Protamine-Based
Drug Delivery System (2003).
Current Status: Principal Scientist, Aventis Inc., Jersey City, NJ.
(10) Dr. Pen Chung Chen
Thesis: Polymer Drug Delivery Systems: Lidocanie and Light-Regulated Drug Release
(2003).
Current Status: Formulation Scientist, Formula Inc., San Francisco, CA.
(11) Dr. Sarita Naik
Thesis: Characterization and Optimization of ATTEMPTS: A Targeted Drug Delivery
System to Reduce Bleeding Risk During Thrombolytic Therapy (12/2004).
Current Status: Research Scientist, Merck Inc. PA.
(12) Dr. Cheol Moon
Thesis: A PTD-Mediated, Polyrotaxane-Based System for Intracellular Delivery of Antitumor Agents (12/2006).
Current Status: .
(13) Dr. Beata Chertok
Thesis: Development of a Magnetically-Targeted MRI-Monitored Nanoplatform for Brain
tumor Drug Delivery (12/2008).
Current Status: Postdoctoral Fellow (Supervisor: Professor Robert Langer), Department of
Chemical Engineering, M.I.T., Cambridge, MA.
(14) Dr. Hee Sun Chung
Thesis: PTD-Mediated Red Blood Cell Encapsulation of L-Asparaginase for Potential
Treatment of Acute Lymphoblastic Leukemia (12/2009).
Current Status: Food & Drug Administration (FDA), Rockville, MD.
(15) Dr. Lei Zhang (in China)
Thesis: Preparation and Biomedical Applications of Superparamagnetic Nanosize Targeting
Drug Carriers. (03/2009).
Current Status: Postdoctoral Fellow (University of Washington).
(16) Dr. Hui-Ning He (in China)
Thesis: Study of enhancing cell membrane permeability of insulin using protein transduction
domain. (01/2010).
Current Status: Postdoctoral Fellow (Supervisor: Professor Victor C. Yang), College of
Pharmacy, UM.
(17) Dr. Wei Bin Dong (in China)
Thesis: Synthesis of Mesoporous Silica Materials and Their Application on Immobilization of
Enzyme (09/2010).
Current Status: Postdoctoral Fellow (Supervisor: Professor Jing Kang Wang), Department
of Chemical Engineering, Tianjin University.
(18) Dr. Adam Cole
Thesis: Enhanced Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors
(04/30/2011).
Current Status: Postdoctoral Fellow (Stanford University).
(19) Dr. Tien Yi Lee
Thesis: Novel Strategy in Cocaine Esterase Modification for Treatment of Cocaine
Intoxication (04/30/2011).
Current Status:
48
* M.S. Students (5)
(1)
(2)
(3)
(4)
(5)
Ms. Katherine Pikal (1994).
Ms. Shirley Poon (2004).
Ms. Ayse Buyuktur (2006).
Ms. Ya Chun Huang (08/2008).
Ms. Lindsay White (08/2009)
* Postdoctoral Fellows (33)
(1)
Dr. Ching-Leou Teng
Current Status: CEO, PharmaEssentia, Lexington, MA.
(2)
Dr. Alexander Tsuei
Current Status: Laboratory Manager, Stationery Products Division, 3M Center, St. Paul, MN
Minneapolis, MN.
(3)
Dr. Jae-Seung Kim
Current Status: Senior Research at TRSL Inc., Ann Arbor, MI.
(4)
Dr. Shu-Ching Ma
Current Status: Group Leader, Sendx Medical Inc., San Diego, CA.
(5)
Dr. Bokhee Kim
Current Status: Research Associate Professor, Kwangwoon University, Seoul, Korea.
(6)
Dr. Enji Wang
Current Status:
Jamaica, NY.
Associate Professor, Chemistry Department, St. John's University,
(7)
Dr. Hai-Han Kuo
Current Status: Senior Scientist, Miles Laboratories, Elkhart, Indiana.
(8)
Dr. Hong Wang
Current Status: Research Scientist, Department of Rheumatology, New England Medical
Center, Boston, Massachusetts.
(9)
Dr. Jong Hoon Yun
Current Status: Associate Research Professor, Kyungpook National University, Taegu,
Korea. Deceased in 1996 due to a tragic car accident.
(10) Dr. Youngro Byun
Current Status: Professor, School of Pharmacy, Seoul National University, Seoul, Korea.
(11) Dr. S. K. Gautam
Current Status: Not Available.
(12) Dr. In-Suk Han
Current Status: CEO, Technology Inc., Salt Lake City, UT.
(13) Dr. Vijendra Singh
Current Status: Associate Research Professor, Department of Biology, Utah State
University, Loan, UT.
(14) Dr. Yuehua Zhang
Current Status: Senior Scientist, Supelco, Inc., Supelco Park, Bellefonte, PA.
(15) Dr. George Zhiqiang Yang
Current Status: Chemist, Michigan State University, Lansing, MI.
(16) Dr. Hui Song
Current Status: Research Assistant, Medical School, University of Michigan.
(17) Dr. Jin Chang
49
Current Status: Professor, School of Materials Science & Engineering, Tianjin University,
Tianjin, China.
(18) Dr. Emel Emregul
Current Status: Associate Professor, Department of Chemistry, University of Ankara,
Ankara, Turkey.
(19) Dr. Yoon Jeong Park
Current Status: Assistant Professor, School of Dentistry, Seoul National University, Seoul,
Korea.
(20) Dr. Junfeng Liang
Current Status: Associate Professor, Department of Chemical Biology, Stevens Institute
of Technology, Hoboken, NY.
(21) Dr. Won Kyu Lee
Current Status: Senior Research Officer, Korea Food & Drug Administration (KFDA),
Seoul, Korea.
(22) Dr. Jun Liu
Current Status: Recently completed postdoctoral training.
(23) Dr. Junbo Gong
Current Status: Associate Professor, School of Chemical Engineering, Tianjin University,
Tianjin, China.
(24) Dr. Cheol Moon
Current Status: Research Scientist,
(25) Dr. Young Min Kwon
Current Status: Assistant Professor, School of Pharmacy, Texas Tech. University, ?? TX.
(26) Dr. Yong Zhuo Huang
Current Status: Assistant Professor, Department of Pharmaceutics, Fudan University,
Shanghai, China.
(27) Dr. Jun Beom Park
Current Status: Assistant Professor, School of Dentistry, Seoul National University,
Seoul, Korea.
(28) Dr. Jian Xin Wang
Current Status: Associate Professor, Department of Pharmaceutics, Fudan University,
Shanghai, China.
(29) Dr. Faquan Yu
Current Status: Professor & Dean, School of Chemical Engineering, Wuhan Science &
Technical University, Wuhan, China.
(30) Dr. Alan David
Current Status: John W. Brown Assistant Professor , Department of Chemical Engineering,
Auburn University, Auburn, Alabama
(31) Dr. Yoon Shin Park
Current Status: Assistant Professor, EHWA University, Seoul, Korea
(32) Dr. Li Mei Han
Current Status: Assistant Professor, School of Pharmacy, Fudan University, Shanghai,
China.
(33) Dr. Mi-Young Lee
Current Status: Dean and Professor, Department of Medical Biotchnology, Soonchunhyang
University, Asan, Korea..
* Technical Assistant (7)
50
(1)
(2)
(3)
(4)
(5)
(6)
(7)
Ms. Huailin Zhang
Ms.Xiaochun Lou
Ms. Yi Zhao
Ms. Liujian Zhao
Ms. Peggy Lee
Ms. Hee-Sung Cheong
Ms. Hsiao-Feng Lee
* Pharm D. Students (11)
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
(11)
Suha Hamid
Debra Hanuscak
Peter Angus
Lai-Ming Lee.
Stella Yeo
Duangkaew Vattanakul
Mary Auyeung
Kristina Chen
Betrice Tsui
Elaine Yu
Christina Lei Aquino
* Undergraduate Students (4)
(1)
(2)
(3)
(4)
Eric Ingber (Chem. Eng.)
Maureen Cornell(Chem. Eng.)
Hannah Hill (Biochemistry)
Sang Yoon Moon (LSA)