Updated 4/25/11
Curriculum Vitae
Cheryl A. Frye
cafrye@albany.edu; fryeca@gmail.com
Life Sciences 1058
US citizen, Native Alaskan
(518) 591-8839 office
(518) 591-8823 lab
H-Index: 45
EDUCATION
Boston University
Department of Biology
1993-1995
NRSA Post-doc, Neuroendocrinology
Tufts University
Psychology Department
1988-1992
M.S., Ph.D., Behavioral Neuroscience
Wheaton College
Biopsychology Department
1984-1988
B.A., cum laude, Biopsychology
POSITIONS & EMPLOYMENT
The University at Albany, SUNY, Full Professor of Psychology
The University at Albany, SUNY, Member, Inst for Health & the Environment
Research Experience for Undergraduates Program at UAlbany, Co-Director
The University at Albany, SUNY, Associate Professor of Psychology
The University at Albany, SUNY, Member, Neuroscience Research Center
The University at Albany, SUNY, Adjunct Professor of Biological Sciences
The University at Albany, SUNY, Assistant Professor of Psychology
The University of Hartford, Department of Biology, Adjunct Professor
Connecticut College, Assistant Professor of Psychology & Zoology, Director of Neuroscience
Wheaton College, Department of Psychology, Visiting Assistant Professor
Boston University, Department of Biology, NIH Post-doctoral Fellow
Bates College, Departments of Psychology & Biology, Visiting Assistant Professor
Wheelock College, Department of Human Development, Instructor
Tufts University, Department of Psychology, TA, RA, Instructor
Boston University, Department of Biology, NSF REU Awardee
Wheaton College, Department of Psychobiology, Research Assistant
Harvard Medical School, Department of Urological Research, Laboratory Technician
Harvard Health, Urgent Care, Medical Associate, Practical Nurse, Ortho/Surg Tech, Manager
2006-present
2003-present
2001-present
2000-2006
1998-present
1998-present
1998-2000
1998-2000
1995-1998
1994-1995
1993-1995
1992-1993
1990-1992
1988-1992
1987-1988
1986-1987
1985-1986
1982-1995
HONORS
Neurobiology of Learning and Memory, Top Cited Article
2008-2010
Boston Latin School, Distinguished Alumna Award (former recipients Bernstein, Kennedy, Fiedler)
2009
The University at Albany, SUNY, CAS Dean Student Mentoring Award
2009
The City of Albany School District, Founder’s Award
2008
The University at Albany, SUNY, Research Excellence Award
2007
Delaware Community School, Volunteer Award
2007
Behavioral Brain Research, Top Reviewer
2007
Research Foundation, Promising Inventor Award
2005
The Society for Neuroscience, Faculty for Undergraduate Neuroscience, Educator of the Year
2003
Wheaton College, Young Alumna Achievement Award
1997
PROFESSIONAL EXPERIENCE
NIH Special Emphasis Review Panel: Drug Abuse
Editorial Board, Frontiers in Experimental Endocrinology
NIH Review Panel: Biobehavioral Regulation, Learning, and Ethology
Veteran’s Affairs: Research Enhancement Program
Veteran’s Affairs: Traumatic Brain Injury Panel
NIH Review Panel: Development of the Parental Brain
National Institute for Psychobiology in Israel Review Panel
NIH Fogarty International Research Collaboration Award Review Panel
NIH Review Panel: International and Cooperative Projects - 1 Study Section
NIH Review Panel: Research Education Program
NIH Review Panel: Fellowships: Brain Disorders and Related Neuroscience
NIH Career Opportunities in Research Honors Undergraduate Research Training Panel
NIH Special Emphasis Review Panel: Fellowships: Behavioral Neuroscience
Alzheimer’s Association Reviews
NIH Special Emphasis Review Panel: Minority Undergraduate Biomedical Education Program
NIH Special Emphasis Review Panel: The CNS as a Target of Steroid Hormones
NIH Special Emphasis Review Panel: Androgens and Aging
NIH Special Emphasis Review Panel: Women’s Health Initiative
NIH Special Emphasis Review Panel: COBRE
NIH Special Emphasis Review Panel: Mechanisms of Stress
NIH Special Emphasis Review Panel - Improving Minority Research Opportunities
American Academy of Neurology, Neuroendocrine Section
Biocontinuum Group (Provides Continuing Medical Education to Neurologists)
Editorial Board, Behavioral Pharmacology
Editorial Board, J Steroids & Hormonal Sci
Guest Editor, Special Issue, Physiology and Behavior, 50th Year of Estrogen Receptor
Guest Editor, Special Issue, Physiology and Behavior, Autism & Androgens
Editorial Board, Pharmacology, Biochemistry & Behavior
Editorial Board, Brain Research
Editorial Board, Physiology & Behavior
International Pharmacology, Biochemistry, & Behavior Conference, Advisory Board
National Institute of Mental Health, IFCN-4 Study Section
International Steroids & Nervous System Conference, Advisory Board
National Institute of Health, Heart, Lung and Blood Study Section
Research Experience for Undergraduate SUNY Summer Program, Co-Founder & Director
North East Under/graduate Research Organization for Neuroscience, Founder & Director
Ad hoc Grant Reviewer: (partial list)
2011
2011
2011
2010
2010
2010
2010
2009
2009-2010
2008-2010
2008-present
2008-2010
2008-2009
2006-2010
2006-2007
2005-2006
2004-2005
2004-2005
2004-2005
2003-2004
2000-2001
2000-present
2004-2009
2010-present
2010-present
2008-2010
2008-2010
2008-present
2002-present
2001-present
2003-2008
2003-2004
2002-present
2001-2003
2000-2004
1996-present
Alzheimer’s Association, Burroughs-Welcome Trust, Epilepsy Foundation of America, Department of Veterans
Affairs- Center for Integrated Healthcare, The National Institute for Psychobiology in Israel, Neurological
Foundation of New Zealand, National Science Foundation and its equivalent agencies in Canada, France, and
Switzerland
Ad hoc Reviewer of Publications: (partial list)
Archives of Medical Research, Behavioral Brain Research, Behavioral Neuroscience, Endocrinology, Hormones
& Behavior, Journal of Neuroendocrinology, Neuropsychopharmacology, Journal of Neuroscience,
2
Pharmacology, Biochemistry & Behavior, Psychoneuroendocrinology, Psychopharmacology, Psychological
Science, Journal of Andrology, Journal of Sexual Medicine, Steroids, Stress
GRANT SUPPORT-ACTIVE ($1,694,970)
“Progestins’ non-classical effects and mechanisms for social & mood processes”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $1,287,752
Dates of Project: 08/15/10-5/31/14
Annual Direct: $212,500
Agency: NIMH, Type: R01
To further understand the role and mechanisms of progestogens to enhance reproduction/social bonds, minimize
aggression, influence affective aspects of social behaviors, and to mediate responses to stress.
“The role of membrane progestin receptors in progestin-facilitated lordosis”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $106,000
Dates of Project: 12/01/09-11/30/11
Annual Direct: $66,007
Agency: NSF, Type: EAGER
To investigate if knockdown or activation of mPRs in rat, and mouse models, alters motor, anxiety-like, or sexual
behavior in rodents. This proposal will determine localization and function of different mPRs in the rodent brain.
"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"
P.I. Cheryl A. Frye, Ph.D.
Total Costs: $103,330
Dates of Proposed Project: 9/1/10-8/31/12
Annual Direct: $34,102
Agency: Karo Bio Type: Drug Contract
To investigate ERβ’s actions in an animal model of andropause and trophic effects on prostate tissues.
“A drug contract to investigate depression -ike behavior of a proprietary estrogen-like compound”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $39,900
Dates of Project: 09/01/10-08/31/11
Annual Direct: $25,000
Agency: Karo Bio Type: Drug Contract
To examine the effects of a proprietary estrogen -ike compounds to improve hormone replacement therapies.
“Northeast Under/graduate Research Organization for Neuroscience 2010-2011”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $10,000
Dates of Project: 4/1/11-3/31/12
Annual Direct: $10,000
Agency: NSF, Type: Conference
To support the 2009-2010 program for this conference oriented to enhanced training of neuroscientists.
“Neuroactive steroids and seizure control during pregnancy in women with epilepsy”
PI: Page Pennell, MD; Co-PI: Cheryl A. Frye, Ph.D.
Total Costs: $51,740
Dates of Project: 7/1/09-6/30/11
Annual Direct: $14,776
Agency: Brigham and Women’s Hospital/NIH, Type: R03
The major goals of this project are to measure levels of progestogens in samples collected from pregnant women.
“Exploratory center on minority health and health disparities in smaller cities- Environmental contaminants and
reproductive health of Akwesasne Mohawk women”
PI: Lawrence Schell, Ph.D.; Collaborator: Cheryl A. Frye, Ph.D.
Annual: $96,248
Dates of Project: 4/1/09-3/31/14
Agency: NIH, Type: P20
The Exploratory Center on Minority Health and Health Disparities in Smaller Cities will support researchers from
multiple disciplines to perform research with community partners to understand the multiple determinants of
health disparities in smaller cities, and by working with community groups, it will test programs to reduce barriers,
and improve utilization and health.
PRIOR EXTRAMURAL SUPPORT ($3,832,633)
“Progestins non-classical effects and mechanisms for social & mood processes”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $378,750
Dates of Project: 09/14/09-09/13/10
Annual Direct: $250,000
Agency: NIMH, Type: R56
To investigate progestin's functional effects and mechanisms through pregnane xenobiotic receptor in cycling and
hormone-primed rats
"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"
P.I. Cheryl A. Frye, Ph.D.
Total Costs: $59,968
Dates of Proposed Project: 9/1/08-8/31/10
Annual Direct: $39,583
Agency: Karo Bio Type: Drug Contract
The main goal of this project is to investigate ERβ’s actions in andropause and the trophic effects of treatment on
prostate tissues.
“A drug contract to investigate behavior and trophic effects of some of their proprietary estrogens that have actions
at estrogen receptor β”
P.I. Cheryl A. Frye, Ph.D.
Total Costs: $69,985
Dates of Proposed Project: 3/1/08-12/31/10
Annual Direct: $43,850
Agency: Karo Bio Type: Drug Contract
This project is for drug development to establish more effective hormone replacement strategies.
“Northeast Under/graduate Research Organization for Neuroscience 2009-2010”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $9,000
Dates of Project: 11/1/09-10/31/10
Annual Direct: $9,000
Agency: NSF, Type: Conference
To support the 2009-2010 program for this student/faculty conference for enhanced training of neuroscientists.
“A conference grant to support the International Conference on Steroids & The Nervous System”
P.I.: Cheryl A. Frye, Ph.D.
Total Direct: $14,000
Period: 2/1/09-1/31/10
Annual Direct: $14,000
Agency: NSF, Type:Conference Grant
This is to support an international conference and to enhance training of neuroendocrinologists at the venue.
“Progestins’ non-genomic actions for sex behavior”
P.I.: Cheryl A. Frye, Ph.D.
Total Costs: $1,146,075
Period: 6/1/04-09/14/09
Annual Direct: ~$150,000
Agency: NIMH, Type: R01
To delineate mechanisms, sources, and effects of progestins underlying appetitive aspects of mating behavior in
rats.
“Conversation in the Capital District”
P.I.: Cheryl A. Frye, Ph.D.
Period: 6/1/08-5/31/10
Total Direct: $80,000
Annual Direct: $80,000
4
Agency: Various
This is to support the Conversation in the Capital District Conference October 23-24, Albany, NY and publication
of a special issue in Physiology & Behavior about this meeting.
“The role of progestins for socio-sexual behavior of mice”
PI/Mentor Cheryl A. Frye, Ph.D.
Total Costs: $59,069
Period: 5/31/08-9/14/09
Annual Direct: $59,069
Trainee: Carolyn J. Koonce, B.A.
Agency: NIMH Type:Post-baccalaureate supplement
This purpose of this project was to investigate progestins role in socio-sexual behavior of mice.
“Mechanisms of estrogen and selective estrogen receptor modulators to reduce anxiety and depression behavior,
without proliferative effects, in a menopausal model”
PI/Mentorr: Cheryl A. Frye, Ph.D.
Total Costs: $90,000
Dates of Project: 6/1/06-5/31/10
Annual Direct: $27,000
Trainee: Alicia Walf
Agency: DOD, BCRP, Type:Pre-doctoral Grant
Goals are to investigate estrogen’s mechanisms to mediate affect concomitant with effects on cell proliferation in
breast and uterine tissues in female rodents.
“Northeast Under/Grad Research Organization for Neuroscience”
P.I. Cheryl A. Frye, Ph.D.
Total Cost: $102,309
Period: 4/1/06-3/31/10
Annual Direct: $34,103
Agency: NIH, Type:Conference Grant
This project is to support a student/faculty conference oriented to enhancing training of neuroscientists.
“Increasing U.S. Participation in 5th Pharmacology, Biochemistry, & Behavior Conference”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $10,000
Period: 4/1/04-3/31/05
Annual Direct: $10,000
Agency: NSF, Type: Conference Grant
The goal of this funding was to provide pedagogical resources and tangible support for senior investigators and
trainees from the U.S.
“Non-genomic actions of progestins in the VTA for lordosis”
PI: Cheryl A. Frye, Ph.D.
Total Cost: $370,000
Period: 9/1/03-8/31/08
Annual Direct: $80,000
Agency: NSF
Investigates progestins’ actions, via signal transduction pathways, to mediate consummatory aspects of mating,
lordosis, of female rodents
“Effects and mechanisms of progestins' modulation of seizure activity”
PI/Mentor: Cheryl A. Frye, Ph.D.
Total Cost: $16,000
Period: 7/01/03-6/30/04
Annual Direct: $16,000
Trainee: Madeline E. Rhodes
Agency: Epilepsy Foundation of America, Type: Ph.D. Fellowship
The major goal of this project was to investigate progestins’ mechanisms in the hippocampus to mediate ictal
activity in a rodent model.
“Actions of estrogen in the nucleus accumbens for conditioning”
PI: Cheryl A. Frye, Ph.D.
Total Cost: $30,000
Period: 6/1/03-5/31/04
Annual Direct: $30,000
Agency: Lilly Centre for Women’s Health, Type: Grant in support of women’s research
The major goals of this project are to investigate estrogens' effects on conditioning and mechanisms in the nucleus
accumbens.
“Increasing U.S. Participation- International Conference on Steroids and Brain”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $15,000
Period: 3/1/03-2/29/04
Annual Direct: $15,000
Agency: NSF, Type: Conference Grant
The goal of this funding was to provide pedagogical resources and tangible support for senior investigators and
trainees from the U.S.
“A summer program in neuroscience at SUNY-Albany”
PI: Gregory Lnenicka, Ph.D., co-PI: Cheryl A. Frye, Ph.D.
Total Costs: $304,200
Period: 4/1/01-3/31/04
Annual Direct: $90,000
Agency: NSF, Type: REU
The major goal of this project was to provide undergraduates neuroscience research experience with a SUNYAlbany faculty member.
“Effects of PDE Inhibitors in an animal model of female sexual dysfunction”
PI: Cheryl A. Frye, Ph.D.
Total Costst: $50,000
Period: 1/1/00-1/1/01
Annual Direct: $50,000
Agency: Eli Lilly, Inc.,Type: Contract
Screened potential therapeutics to determine effects on female sexual responsiveness in hamsters. This contact was
an essential part of the development and/or approval of the drug Cialis.
“NEURON: North East Under/graduate Research Organization for Neuroscience”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $86,274
Period: 9/1/99-8/31/04
Annual Direct: $17,250
Agency: NIMH, Type: R13
The major goals of this project were to support a student/faculty conference oriented to enhanced training of
neuroscientists.
“Neurosteroids effects on sexual receptivity”
PI: Cheryl A. Frye, Ph.D.
Total Cost: $539,003
Period: 2/1/96-8/31/03
Annual Direct: $539,003
Agency: NSF, Type: CAREER Grant
Investigated actions of progestins via GABAA receptors to mediate lordosis of female rodents.
“Neurosteroids’ role in cognitive, affective, & neurodegenerative disorders"
PI: Cheryl A. Frye, Ph.D.
Total Cost: $90,000
Period: 6/1/96-5/31/00
Annual Direct: $90,000
Agency: Whitehall Foundation, Type: Grant-in-Aid
Investigated neurosteroids role in cognitive and affective behavior and neurodegenerative disorders.
6
“Neurosteroids’ role in epilepsy”
PI: Cheryl A. Frye
Total Cost: $180,000
Period: 6/1/96-8/31/00
Annual Direct: $180,000
Agency: Donaghue Fdn , Type: Young Investigator Award
Examined progestins' effects on ictal activity in animal models of catamenial epilepsy.
“Progestins’ actions in the VTA for lordosis”
PI: Cheryl A. Frye, Ph.D.
Total Cost: $25,000
Period: 2/1/96-1/31/97
Annual Direct: $25,000
Agency: NIMH, Type: B-START
Although funded, declined award to pursue CAREER grant, which had overlapping research aims.
“Androgens’ actions for inhibiting sexual receptivity”
PI/Mentor: Mary S. Erskine, Ph.D.
Total Cost: $83,000
Period: 1/1/93-8/31/95
Annual Direct: $83,000
Trainee: Cheryl A. Frye, Ph.D.
Agency: NIMH,Type: F32
Examined effects and mechanisms of androgenic neurosteroids to inhibit sexual receptivity in rodents.
“Neurosteroids’ role in affect and cognition”
PI: Cheryl A. Frye, Ph.D
Total Cost: $25,000
Period: 5/1/93-4/30/94
Annual Direct: $25,000
Agency: NSF, Type: Research Planning Grant
A grant to investigate how neurosteroids alter cognition, affective and feeding and pain processes.
INTRAMURAL SUPPORT ($459,300)
SOURCE
TYPE
TIME
FUNDS
SUNY-Albany
Contraceptives Awareness Support
Spring 2010
$650
SUNY-Albany
Brain Awareness Week Support
Spring 2010
$650
Research Foundation Conference Support Award- CID
Spring 2009
$1500
Research Foundation Conference Support Award- CID
Spring 2009
$1500
SUNY-Albany
Faculty Research Award Program- B
Spring 2009
$3000
SUNY-Albany
Brain Awareness Week Support
Spring 2009
$750
Research Foundation Conversation in the Discipline
Fall 2008
$1000
SUNY-Albany
Conversation in the Discipline
Fall 2008
$5000
SUNY-UAS
Conversation in the Discipline
Fall 2008
$1000
SUNY-Albany
Conversation in the Discipline
Fall 2008
$5000
SUNY-Albany
Symposium Support
Spring 2008
$500
SUNY-Albany
Brain Awareness Week Support
Spring 2008
$1,500
SUNY-Albany
Conference Support Grant
Spring 2008
$1,500
SUNY-Albany
McNair Minority Student Support
Summer 2004
$3,000
SUNY-Albany
Research Incentive Award
Summer 2004
$5,000
SUNY-Albany
Conference Support Grant
Spring 2004
$700
SUNY-Albany
Affirmative Action Grant
Summer 2003
$250
SUNY-Albany
Research Incentive Award
Summer 2003
$5,000
SUNY-Albany
Affirmative Action Grant
Summer 2002
$700
SUNY-Albany
McNair Minority Student Support
Summer 2002
$1,000
SUNY-Albany
McNair Minority Student Support
Summer 2001
$1,000
SUNY-Albany
STAR Undergrad Research Grant
October 2001
$1,000
SUNY-Albany
Faculty Research Award Program
February 2001
$10,000
SUNY-Albany
Professional development Award
January 2001
$800
SUNY-Albany
Professional development Award
May 1999
$1,000
SUNY-Albany
Faculty Research Award Program
December 1998
$10,000
SUNY-Albany
Start-up Funds
September 1998
$77,000
Connecticut College
Pfizer Foundation
1995-1998
$200,000
Connecticut College
Johnson Fund
1995-1998
$4,300
Connecticut College
Start-up Funds
September 1995
$100,000
Bates College
Howard Hughes Research Program
Summer 1993
$3,500
Bates College
Schmutz Grant for Faculty Research
December 1992
$5,000
Bates College
Start-Up Funds for 1 year
Appointment
September 1992
$5,000
Tufts University
Dissertation Research Grant
February 1991
$1,500
SMALL GRANTS ($113,850)
SOURCE
TYPE
TIME
FUNDS
Amerisciences
Research Trainee Support
Fall 2008
$4,500
Elsevier
Support for Conversation in the
Discipline
Summer 2008
$61,000
Amerisciences
Summer Research Fellowship for Jon
Freidman
Summer 2008
$2,000
NIH
Microarray Consortium
Spring 20082009
$6,000
NIH
Microarray Consortium
Spring 20082009
$6,000
NIH
Microarray Consortium
Spring 20082009
$6,000
8
NIH
Microarray Consortium
Summer 20072008
$6,000
NIH
Microarray Consortium
January 2008
$11,150
Harvard Pilgrim
Health Care
NEURON mentoring project
Fall 2007-2008
$500
NIH
Microarray Consortium
January 2007
$3150
Epilepsy F’dation
Summer Fellowship
April 2000
$2,000
Endocrine Society
Summer Fellowship
April 1999
$2,500
Parkinsons F’dation
Summer Fellowship
February 2001
$900
Sigma Xi
Grant-in-Aid
March 1991
$750
Sigma Xi
Grant-in-Aid
August 1990
$800
Sigma Xi
Grant-in-Aid
March 1989
$600
TRAVEL GRANTS ($13,250)
SOURCE
TYPE
TIME
FUNDS
SUNY-Albany
Travel Grant
Spring 2009
$500
SUNY-Albany
Travel Grant
Spring 2008
$1,500
NIAAA
Travel Grant
September 2006
$1,500
SUNY-Albany
Faculty Travel Award
January 2006
$900
SUNY-Albany
Faculty Travel Award
February 2003
$900
ACNP
Young Investigator Fellowship
January 2002
$2,000
Neurobio Epilepsy
Young Investigator Fellowship
May 2001
$1,500
SUNY-Albany
Faculty Travel Award
February 2001
$900
SUNY-Albany
Faculty Travel Award
May 2000
$850
WCBR
Post-Doc Travel Award
January 1994
$1,500
Workshop Steroids
Post-Doc Travel Award
March 1993
$1,200
REFEREED-PUBLICATIONS
240. Frye, C.A., Paris, J.J. (2011). Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental
area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female
rats. J Endocrin Invest. (in press).
239. Paris, J.J., Frye, C.A. (2011). Gestational exposure to variable stressors produces decrements in cognitive
and neural development of juvenile male and female rats. Curr Top Med Chem (in press).
238. Frye, C.A., Rhodes, M.E. (2011) Fluoxetine-induced decrements in sexual responses of female rats and
hamsters are reversed by 3,5-THP. Journal of Sexual Medicine (in press).
237. Walf, A.A., Paris, J.J., Rhodes, M.E., Simpkins, J.W., Frye, C.A. (2011). Divergent mechanisms for trophic
actions of estrogens in the brain and peripheral tissues. Brain Research, 1379: 119-36.
236. Frye, C.A., Hirst, J.J., Brunton, P.J., Russell, J.A. (2011). Neurosteroids for a successful pregnancy. Stress,
14: 1-5.
235. Walf A.A., Paris, J.J., Llaneza, D.C., Frye, C.A. (2011). I. Levels of 5α-reduced progesterone metabolite in
the midbrain account for variability in reproductive behavior of middle-aged female rats. Brain Research
1379:137-48.
234. Paris J.J., Walf, A.A., & Frye, C.A. (2011). II. Cognitive performance of middle-aged female rats is
influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus. Brain Research;
1379:149-63.
233. McFadden, L. M., Paris, J.J., Mitzelfelt, M.S., McDonough, S., Frye, C.A., Matuszewich, L. (2011) Sexdependent persistent effects of chronic unpredictable stress in the water maze. Physiol Behav. 102; 266-75.
232. Frye, C.A. (2011). Progesterone reduces depressive behavior of young ovariectomized, aged progestin
receptor knockout, and aged wild type mice in the tail suspension test. Journal of Psychopharmacology, 25: 4218.
231. Frye, C.A., Paris J.J. (2011). Effects of neurosteroid actions at N-methyl-D-aspartate and GABAA receptors
in the midbrain ventral tegmental area influence engagement in natural reward and motivation to explore among
ovariectomized/adrenalectomized female rats. Psychopharmacology, 213: 93-103.
230. Frye, C.A. and Walf, A.A. (2011). Progesterone, administered before kainic acid, reduces decrements in
cognitive performance in the Morris Water Maze. Developmental Neurobiologyy, 71:142-52.
229. Paris, J.J., Frye, C.A. (2011). Juvenile offspring of rats exposed to restraint stress in late gestation have
impaired cognitive performance and dysregulated progestogen formation. Stress 14, 23-32.
228. Lynn, C.D., Paris, J.J., Frye, C.A., Schell, L.M. (2010). Salivary alpha-amylase as proxy of sympathetic
nervous system activity in biocultural research: Comparison to salivary cortisol in Pentecostals. Am J Hum Biol.
22, 819-22.
227. Frye, C.A., Walf, A.A., & Paris, J.J. (2010). Conjugated equine estrogen, with medroxyprogesterone acetate,
enhances formation of 5-reduced progestogens and anti-anxiety behavior of middle-aged rats. Behavioral
Pharmacology, 21, 530-9.
226. Franco, C., Paris, J.J., Wulfert, E., & Frye, C.A. (2010) Male gamblers have significantly greater salivary
cortisol before and after betting on a horse race, than do female gamblers. Physiology and Behavior, 99, 225-9.
225. Frye, C.A. (2010). Effects and mechanisms of progestogens and androgens in ictal activity. Epilepsia 51
suppl 3, 135-40
224. Frye, C.A., Bloom M.S., Wersinger S. (2010). The 50th anniversary of the discovery of the estrogen
receptor—conversations about hormones then and now. Physiology and Behavior 99, 147-8.
223. Frye, C.A., Bloom M.S. & Wersinger S. (2010). Androgens, autism and more. Physiology and Behavior
100, 197-8.
222. Frye, C.A., Edinger, K.L., Lephart, E.D., Walf, A.A. (2010). 3α-androstanediol, but not testosterone,
attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats. Frontiers in Aging
Neuroscience 2, 1-21.
221. Frye, CA., Koonce, C, & Walf, AA. (2010). Mnemonic effects of progesterone to mice require formation of.
3,5-THP. NeuroReport 21, 590-5.
220. Frye, C.A. & Llaneza, D.C. (2010). Corticosteroid and neurosteroid dysregulation in an animal model of
autism, BTBR mice. Physiology and Behavior 100; 264-7.
219. Frye, C.A., Petralia, S.M., Rhodes, M.E., DeBold, J.F. (2010). 6-hydroxydopamine lesions enhance
progesterone –facilitated lordosis of rats and hamsters, independent of effects on motor behavior. Physiology and
Behavior 99, 218-24.
10
218. Frye, C.A. & Sora, I. (2010). Progesterone reduces hyper-activity of female and male dopamine transporter
knockout mice. Behavioural Brain Research 209, 59-65.
217. Frye, C.A. & Walf, A.A. (2010). Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral
tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate lordosis.
Behavioural Brain Research 206, 286-92.
216. Frye, C.A. & Walf, A.A. (2010) Oxytocin and/or steroid hormone binding globulin infused into the ventral
tegmental area modulates progestogen-mediated lordosis. Neuropharmacology 58, 44-9.
215. Frye, C.A. & Walf, A.A. (2010). Progesterone enhances learning and memory of aged wildtype and progestin
receptor knockout mice. Neuroscience Letters 472, 38-42.
214. Jensen E.V., Jacobson H.I., Walf A.A., Frye C.A. (2010). Estrogen action: A historic perspective on the
implications of considering alternative approaches. Physiology and Behavior 99, 151-62.
213. Kohtz, A.S., Paris, J.J., Frye, C.A. (2010). Low doses of cocaine decrease, and high doses increase, anxietylike behavior and brain progestogen levels among intact rats. Hormones and Behavior 57, 474-80.
212. Llaneza, D.C., DeLuke, S.V., Batista, M., Crawley, J.N., Christodulu, K.V. & Frye, C.A. (2010).
Communication, interventions, and scientific advances in autism: A commentary. Physiology and Behavior
100;268-76.
211. Lynn, C.D., Paris J., Frye C.A,. Schell L.M.. (2010) Salivary alpha –amylase and cortisol among
pentecostals on a worship day and nonworship day. American Journal of Human Biology. 22, 819-22
210. Paris J.J., Franco, C., Sodano, R., Frye, C.A., & Wulfert, E. (2010). Gambling pathology is associated with
dampened cortisol response among men and women. Physiology and Behavior 99, 230-3.
209. Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Gordis, E., Anderson, D.A., Forsyth, J.P., Wulfert, E., &
Frye, C.A. (2010). Sex differences in salivary cortisol in response to acute stressors among healthy participants, in
recreational or pathological gamblers, and in those with postraumatic stress disorder. Hormones and Behavior 57,
35-45
208. Walf, A.A. & Frye, C.A. (2010). Raloxifene and/or estradiol reduce depressive-like behavior and increase
anti-anxiety-like behavior, whereas only estradiol promotes uterine proliferation and carcinogen-induced
tumorigenesis among ovariectomized rats. Behavioral Pharmacology 21, 231-40.
207. Walf, A.A. & Frye, C.A. (2010). Estradiol reduces anxiety- and depression-like behavior of aged female
mice. Physiology and Behavior 99, 169-74.
206. Frye, C.A. & Koonce, C.J. (2009). Post-training administration of estrogen and/or androgens with actions at
ERα and/or ERβ to male rats can improve performance in the object recognition task. Open
Neuropsychopharmacology Journal 2, 16-21.
205. Frye C.A. (2009). Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical
functions. Psychoneuroendocrinology 34 Suppl 1, S143-61.
204. Frye, C.A. (2009). Steroids, reproductive endocrine function, and affect: A review. Minerva Ginecological
61, 541-562.
203. Frye, C.A. (2009). Steroids, reproductive endocrine function, and cognition: A review. Minerva
Ginecological 61, 563-585.
202. Frye, C.A., Llaneza, D.C. & Walf, A.A. (2009) Progesterone can enhance consolidation and/or performance
in spatial, object, social, and implicit memory tasks. Animal Behaviour 78, 279-286.
201. Frye, C.A. & Paris, J.J. (2009). Infusions of bicuculline to the ventral tegmental area attenuates sexual,
exploratory, and anti-anxiety behavior of proestrous rats. Pharmacology, Biochemistry, and Behavior 93, 474-81.
200. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2009). Increasing 3α,5α-THP following inhibition of neurosteroid
biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive
rats. Reproduction 137, 119-28.
199. Frye, C.A.(2009):Progestogens influence cognitive processes in aging. 1, 1215-1231.Future Medicinal
Chemistry, October 2009, Vol. 1, No. 7, Pages 1215-1231.
198. Frye, C.A. & Walf, A.A. (2009) Progesterone reduces depression-like behavior in a murine model of
Alzheimer’s Disease. Age 31, 143-53.
197. Frye, C.A. & Walf A.A. (2009).Depression-like behavior of aged male and female mice is ameliorated with
administration of testosterone or its metabolites. Physiology and Behavior 97, 266-269.
196. Frye, C.A., Ryan, A., & Rhodes, M. (2009). Anti-seizure effects of 17β-estradiol and 3α-androstanediol may
Inolve actions at estrogen receptor β. Epilepsy and Behavior 16, 418-22.
195. Gracia, C.R., Freeman, E.W., Sammel, M.D., Lin, H., Sheng, L., & Frye, C.A. (2009). Allopregnanolone
levels before and after SSRI treatment for Premenstrual Symptoms. Journal of Clinical Psychopharmacology 29,
403-5.
194. Koonce, C.J., Walf, A.A., & Frye, C.A. (2009). Trilostane exerts anti-depressive effects among wildtype, but
not estrogen receptor β knockout mice. Neuroreport 20, 1047-50.
193. Llaneza D.C. & Frye C.A. (2009). Progestogens and estrogen influence impulsive burying and avoidant
freezing behavior of naturally cycling and ovariectomized rats. Pharmacol Biochem Behav 93, 337-42.
192. Osborne, D.M., Edinger, K., & Frye, C.A. (2009). Chronic administration of androgens with actions at
estrogen receptor β have anti-anxiety and cognitive-enhancing effects in male rats. Age 31, 191-8.
191. Osborne, D.M. & Frye C.A. (2009) Estrogen increases latencies to seizures and levels of 5alpha-pregnan3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout mice. Epilepsy and Behavior
16, 411-4.
190. Walf A.A. & Frye C.A. (2009). Estradiol enhances sociosexual behavior and can have proliferative effects in
ovariectomized rats. Age (Dordr) 31, 221-9.
189. Walf, A.A. & Frye, C.A. (2009). Effects of two estradiol regimens on anxiety and depressive behaviors and
trophic effects in peripheral tissues in a rodent model. Gender Medicine 6, 300-11.
188. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Chronic estradiol replacement to aged female rats reduces
anxiety-like and depression-like behavior and enhances cognitive performance. Psychoneuroendocrinology 34,
909-16.
187. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Nociceptive and anxiety-like behavior in reproductively
competent and reproductively senescent middle-aged rats. Gender Medicine 6, 235-246.
186. Walf A.A., Koonce C.J., Frye C.A. (2009). Adult female wildtype, but not oestrogen receptor beta knockout,
mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or
diarylpropionitrile. J Psychopharmacol 23, 442-50.
185. Frye, C.A., Koonce, C.J., Edinger, K.L., Osborne D.M., & Walf, A.A. (2008). Androgens with activity at
estrogen receptor β have anxiolytic and cognitive-enhancing effects in male rats and mice. Hormones and
Behavior 54, 726-734.
184. Walf, A.A. & Frye, C.A. (2008). Rapid and estrogen receptor β mediated actions in the hippocampus
mediate some functional effects of estrogen. Steroids 73, 997-1007.
183. Frye, C.A. & Walf, A.A. (2008). Membrane actions of progestins at dopamine type 1-like and GABAA
receptors involve downstream signal transduction pathways. Steroids, 73, 906-13.
12
182. Frye, C.A., Marrone, J., & Walf, A.A. (2008). Effects of manipulating progesterone and NMDA receptors in
the ventral tegmental area and lordosis of hamsters and rats. Psychopharmacology 200, 71-80.
181. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2008). Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5αTHP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective
behavior of ovariectomized rats. Pharmacology, Biochemistry and Behavior 91, 261-270.
180. Frye C.A., Paris, J.J., & Rhodes, M.E. (2008). Exploratory, anti-anxiety, social, and sexual behaviors of rats
in behavioral estrus is attenuated with inhibition of 3α,5α-THP formation in the midbrain ventral tegmental area.
Behavioural Brain Research 193, 269-276.
179. Frye, C.A. & Rhodes, M.E. (2008). Infusions of 3α,5α-THP to the VTA enhance exploratory, anti-anxiety,
social, and sexual behavior and increase levels of 3α,5α-THP in midbrain, hippocampus, diencephalon, and cortex
of female rats. Behavioural Brain Research, 187, 88-99.
178. Frye, C.A., Sumida, K., & Edinger, K.L. (2008). Androgen administration to aged male mice increases antianxiety behavior and enhances cognitive performance. Neuropsychopharmacology 33, 1049-1061.
177. Frye, C.A. & Walf A.A. (2008). In the ventral tegmental area, progestogens membrane-mediated actions for
lordosis of rats involve the second messenger phospholipase C. Brain Research 1230, 218-223.
176. Frye, C.A. & Walf, A.A. (2008). Activity of protein kinase C is important for 3α,5α-THP's actions at
dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats. Brain Research
Bulletin 77 91-97.
175. Frye, C.A. & Walf, A.A. (2008). Progesterone to ovariectomized mice enhances cognitive performance in
the spontaneous alternation, object recognition, but not placement, water maze. Neurobiology of Learning and
Memory 90, 171-177.
174. Frye, C.A. & Walf, A.A. (2008). Progesterone enhances performance of aged mice in cortical or
hippocampal tasks. Neuroscience Letters 437, 116-120.
173. Frye, C.A. & Walf, A.A. (2008). Effects of progesterone administration and APPswe+PSEN1e9 mutation
for cognitive performance of mid-aged mice. Neurobiology of Learning and Memory 89, 17-26.
172. Paris J.J. & Frye, C.A. (2008). Estrous cycle, pregnancy, and parity enhance performance of rats in object
recognition or object placement tasks. Reproduction 136, 105-115.
171. Ryan, A. & Frye, C.A. (2008). Antiseizure effects of 5α-androstane-3α,7β-diol may be independent of
actions at estrogen receptor β. Epilepsy and Behavior 13, 32-35.
170. Walf, A.A, Ciriza, I., Garcia-Segura, L.M.., & Frye, C.A. (2008). Antisense oligodeoxynucleotides for
estrogen receptor  and  attenuate estradiol's modulation of affective and sexual behavior, respectively.
Neuropsychopharmacology 33, 431-440.
169. Walf, A.A. & Frye, C.A. (2008). Conjugated equine estrogen enhances rats’ cognitive, anxiety, and social
behavior. Neuroreport 19, 789-792.
168. Walf, A.A. & Frye, C.A. (2008). Parity and estrogen-administration alters anxiety and depression behavior of
ovariectomized rats. Physiology and Behavior 93, 351-356.
167. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Adult female wildtype, but not estrogen receptor 
knockout, mice have decreased depression-like behavior during proestrus and following administration of estradiol
or diarylpropionitrile. Journal of Psychopharmacology 23, 442-50.
166. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Estrogen or diarylpropionitrile administration to wildtype, but
not estrogen receptor β knockout, mice enhance performance in the object recognition and object placement tasks.
Neurobiology of Learning and Memory 89, 513-521.
165. Walf, A.A., Koonce, C.J., & Frye, C.A. (2008). Estradiol or diarylpropionitrile decrease anxiety-like
behavior of wildtype, but not estrogen receptor β knockout, mice. Behavioral Neuroscience 122, 974-81.
164. Walf, A.A., Koonce, C.J., Manley, K., & Frye, C.A. (2008). Proestrous compared to diestrous wildtype, but
not estrogen receptor β knockout, mice have better performance in the spontaneous alternation and object
recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behavioural Brain
Research 96, 254-60.
163. Walf, A.A., Frye, C.A. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in
rodents. Nature Protocols 2:322-328.
162. Edinger, K.L & Frye, C.A. (2007). Sexual experience of male rats influences anxiety-like behavior and
androgen levels. Physiology and Behavior 92, 443-53.
161. Edinger, K.L. & Frye, C.A. (2007). Androgens' effects to enhance learning and memory may be mediated in
part through actions at estrogen receptor- in the hippocampus. Neurobiology of Learning and Memory 87, 201-8.
160. Frye, C.A. (2007). Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of
abuse. Pharmacology, Biochemistry, and Behavior 86, 209-219.
159. Frye, C.A. (2007). Some rewarding effects of androgens may be mediated by actions of its 5-reduced
metabolite 3–Androstanediol. Pharmacology, Biochemistry, and Behavior 86, 354-367.
158. Frye, C.A., Babson, A., & Walf, A.A., (2007). Self-Administration of 3-Androstanediol increases antianxiety behavior and decreases aggressive behavior of male hamsters. Pharmacology, Biochemistry, and Behavior
86, 415-421.
157. Frye, C.A., Paris, J.J. & Rhodes, M.E. (2007). Engaging in paced mating, but neither exploratory, antianxiety, nor social behavior, increases 5-reduced progestin concentrations in midbrain, hippocampus, striatum
and cortex. Reproduction 1133, 663-674.
156. Frye, C.A, & Rhodes, M.E. (2007). Infusions of 5-pregnan-3-ol-20-one (3,5-THP) to the ventral
tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and
concomitantly increase 3,5-THP concentrations in the hippocampus, diencephalon and cortex of
ovariectomised oestrogen-primed rats. Journal of Neuroeondocrinology 18, 960-75.
155. Frye, C.A. & Walf, A.A. (2007). In the ventral tegmental area, the membrane-mediated actions of progestins
for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. Journal of
Neuroendocrinology 19, 717-724.
154. Kellogg, C.K., Kenjarsk,i T.P., Pleger, G.L., & Frye, C.A. (2006). Region-, age-, and sex-specific effects of
fetal diazepam exposure on the postnatal development of neurosteroids. Brain Research 1067, 115-25.
153. Petralia, S.M., Debold, J.F., & Frye, C.A. (2007). MK-801 Infusions to the VTA and VMH produce opposite
effects on lordosis of hormone-primed rats. Pharmacology, Biochemistry, and Behavior 86, 377-385.
152. Walf, A.A., Duffy, C.K., & Frye, C.A. (2007).Estrogens and progestins enhance spatial learning of intact and
ovariectomized rats in the object placement task. Neurobiology of Learning and Memory 88, 208-216
151. Walf, A.A. & Frye, C.A. (2007). Estradiol decreases anxiety behavior and enhances inhibitory avoidance and
gestational stress produces opposite effects. Stress 10, 251-260.
150. Walf, A.A. & Frye, C.A. (2007). Administration of estrogen receptor  selective estrogen receptor
modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats. Pharmacology,
Biochemistry, and Behavior 86, 407-414.
149. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., & Edinger, K.L. (2006). 3α,5α-THP in
the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 138, 1007-14
14
148. Frye, C.A. (2006). An overview of contraceptives: Mechanism of action and clinical use. Neurology 66,
S29-36
147. Frye, C.A. (2006). The role of androgens in epilepsy. Expert Review of Neurotherapeutics 6, 7:1061-1076.
146. Walf, A.A., Frye, C.A. (2006). A review and update: Estrogen’s effects, brain targets, and mechanisms for
anxiety and depression behavior Neuropsychopharmacology, 31(6):1097-111.
145. Ciriza, I., Carrero, P., Walf, A.A., Frye, C.A., & Garcia-Segura, L.M. (2006). Reduced metabolites mediate
neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin
mderoxyprogesterone acetate is not neuroprotective. Journal of Neurobiology 66, 916-28.
144. Edinger, K.L & Frye, C.A. (2006). Androgens' cognitive-enhancing effects may involve actions at
intracellular androgen receptors in the dorsal hippocampus. Neurobiology of Learning and Memory 50, 216-22.
143. Edinger, K.L. & Frye C.A. (2006). Intrahippocampal administration of an androgen receptor antagonist,
flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats. Hormones and Behavior 50,
216-220.
142. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves
adenylyl cyclase activity in the ventral tegmental area.. Hormones and Behavior 50, 237-44.
141. Frye, C.A, & Rhodes, M.E. (2006) Progestin concentrations are increased following paced mating in
midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous
rats. Neuroendocrinology 83, 336-47.
140. Frye, C.A, & Rhodes, M.E. (2006). Administration of estrogen to ovariectomized rats promotes conditioned
place preference and produces moderate levels of estrogen in the nucleus accumbens. Brain Research 1067, 209215.
139. Frye CA, Rhodes ME, Raol Y, & Brooks-Kayal AR. (2006). Early postnatal stimulation alters pregnane
neurosteroids in the hippocampus. Psychopharmacology 186, 343-50.
138. Frye. C.A., Sumida, K., Dudek, B.C., Harney, J.P., Lydon, J.P., O'Malley, B.W., Pfaff, D.W., & Rhodes,
M.E. (2006). Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular
progestin receptors. Psychopharmacology 186, 312-22.
137. Frye, C.A., Sumida, K., Lydon, J.P., O’Malley, B.W., & Pfaff, D. (2006). Mid-aged and aged wild-type and
progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3,5-THP-facilitated lordosis.
Psychopharmacology 186, 423-32.
136. Frye CA, Sumida K, Zimmerberg B, & Brunelli SA. (2006). Differences in sexual behavior and midbrain
3,5-THP levels of adult rats bred for high-anxiety responses postnatally. Behavioral Neuroscience 120, 281-9.
135. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestins’ effects on sexual behavior of female rats and
hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent.
Behavioral Brain Research 172, 286-293.
134. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). In the ventral tegmental area, progestins have actions at D1
receptors for lordosis of hamsters and rats that involve GABAA receptors. Hormones and Behavior 50, 332-7.
133. Frye, C.A., Walf, A.A, & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves adenylyl
cyclase activity in the ventral tegmental area. Hormones and Behavior 50, 332-337.
132. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L.,
& Frye, C.A. (2006). Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy.
Epilepsia 47, 1945-8.
131. Petralia, S.M. & Frye, C.A. (2006). In the ventral tegmental area, G-proteins mediate progesterone’s actions
at dopamine type 1 receptors for lordosis of rats and hamsters Psychopharmacology 186, 133-42.
130. Petralia SM, & Frye CA. (2006). In the ventral tegmental area, cAMP mediates progesterone’s actions at
dopamine type 1 receptors for lordosis of rats and hamsters. Journal of Neuroendocrinology 18, 902-14.
129. Petralia, S.M., Walf, A.A., & Frye, C.A. (2006). In the ventral tegmental area, progestins’ membranemediated actions for lordosis of hamsters and rats involve protein kinase A. Neuroendocrinology 84, 405-414.
128. Rhodes, M.E. & Frye, C.A. (2006). ER-selective SERM produce mnemonic-enhancing effects in the
inhibitory avoidance and water maze tasks. Neurobiology of Learning Memory 85, 183-91.
127. Smith, C.D., Wekstein, D.R., Markesbury, W.R., & Frye, C.A. (2006). 3, 5-THP: a potential plasma
neurosteroid biomarker in Alzheimers Disease. Psychopharmacology 186, 481-485.
126. Walf, A.A., Rhodes, M.E., Meade, J., Harney, J.P., & Frye, C.A. (2006). Estradiol-induced conditioned place
preference may require actions at estrogen receptors in the nucleus accumbens. Neuropsychopharmacology 32,
522-530.
125. Walf, A.A., Rhodes, M.E., & Frye, C.A. (2006). Ovarian steroids enhance object recognition in naturallycycling and ovariectomized, hormone-primed rats. Neurobiology of Learning and Memory 86, 35-46.
124 Walf, A.A., Sumida, K., & Frye, C.A. (2006). Inhibiting 5-reductase in the amygdala attenuates antianxiety and anti-depressive behavior of naturally-receptive and hormone-primed ovariectomized rats.
Psychopharmacology 186, 302-311.
123. Frye, C.A. & Rhodes, M.E. (2005) Estrogen-priming can enhance progesterone’s anti-seizure effects in part
by increasing hippocampal levels of allopregnanalone. Pharmacology, Biochemistry, and Behavior 81, 907-16.
122. Rhodes, M.E., Talluri, J., Harney, J.P., & Frye, C.A. (2005). Ketogenic diet decreases circulating
concentrations of neuroactive steroids of female rats. Epilepsy and Behavior 7, 231-9.
121. Frye, C.A., & Rhodes, M.E. (2005). Progesterone’s 5-reduced metabolite, 3, 5-THP, mediates lateral
displacement of hamsters. Brain Research 1038, 59-68.
120. Frye, C.A., Rhodes, M.E., & Dudek, B.C. (2005). Estradiol to aged female or male mice improves learning
in inhibitory avoidance and water maze tasks. Brain Research 1036, 101-8.
119. Frye, C.A., Rhodes M.E., & Dudek B.C. (2005). Estradiol to aged male mice improves learning in inhibitory
avoidance and water maze tasks. Brain Research 1036, 101-8.
118. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L.,
& Frye, C.A. (2005). Differential effects of antiepileptic drugs on sexual function and hormones in men with
epilepsy. Neurology 65, 1016-20.
117. Petralia, S.M. & Frye, C.A. (2005). In the ventral tegmental area, picrotoxin blocks FGIN-1-27-induced
increases in sexual behavior of rats and hamsters. Psychopharmacology,178, 174-82.
116. Petralia SM, Jahagirdar V, & Frye CA. (2005). Inhibiting biosynthesis and/or metabolism of progestins in the
ventral tegmental area attenuates lordosis of rats in behavioural oestrus. Journal of Neuroendocrinoogy 17, 54552.
115. Rhodes, M.E. & Frye, C.A. (2005). Attenuating 5-pregnane-3-0l-20-one formation in the hippocampus of
female rats increases pentylenetetrazole-induced seizures. Epilepsy and Behavior 6; 140-6.
114. Rhodes M.E. & Frye C.A. (2005). Actions at GABAA receptors in the hippocampus may mediate some of
progestins’ anti-seizure effects. Epilepsy and Behavior 6, 320-7.
113. Smith, S.S., Ruderman, Y., Frye, C., Homanics, G., & Yuan, M.(2005). Steroid withdrawal in the mouse
results in anxiogenic effects of 3α,5α-THP: a possible model of premenstrual dysphoric disorder.
Psychopharmacology 29, 1-11.
112. Sumida, K., Walf, A.A., & Frye, C.A. (2005). Progestin-facilitated lordosis of hamsters may involve
dopamine-like type 1 receptors in the ventral tegmental area. Behavioural Brain Research 3, 161, 1-7.
16
111. Walf, A.A. & Frye, C.A. (2005). Antianxiety and antidepressive behavior produced by physiological
estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. Neuropsychopharmacology,
30, 1288-301.
110. Walf, A.A. & Frye, C.A. (2005). ER -selective estrogen receptor modulators produce anti-anxiety behavior
when administered systemically to ovariectomized rats. Neuropsychopharmacology 30, 1598-609.
109. Zimmerberg, B., Brunelli, S. A., Fluty, A. J., & Frye, C. A. (2005). Differences in affective behaviors and
hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations. Behavioral
Brain Research, 159: 301-11.
108. Rhodes, M.E. & Frye, C.A. (2004). Androgens in the hippocampus can alter, and be altered by, ictal activity.
Pharmacology, Biochemistry, and Behavior 78, 483-493.
107. Edinger, K.L. & Frye, C.A. (2004). Testosterone’s analgesic, anxiolytic, and cognitive-enhancing effects
may be due in part to actions of its 5-reduced metabolites in the hippocampus. Behavioral Neuroscience 118,
1352-64.
106. Edinger, K.L., Lee, B., & Frye, C.A. (2004). Mnemonic effects of testosterone and its 5-reduced
metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacology, Biochemistry, & Behavior 78,
559-568.
105. Frye, C.A & Edinger, K.L. (2004). Testosterone’s metabolism in the hippocampus mediates its anti-anxiety
effects in male rats. Pharmacology, Biochemistry, & Behavior 78, 473-481.
104. Frye, C.A., Edinger, K.L.,Seliga, A.M., & Wawrzycki, J.M. (2004). 5-reduced androgens may have actions
in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 29, 1019-1027.
103. Frye, C.A. & Walf, A.A. (2004). Hippocampal 3,5-THP may alter depressive behavior of pregnant and
lactating rats. Pharmacology, Biochemistry, & Behavior 78, 531-540
102. Frye, C.A. & Walf, A.A. (2004). Estrogen and/or progesterone administered systemically or to the amygdala
can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats. Behavioral Neuroscience 118, 306-13.
101. Frye, C.A., Walf, A.A., & Sumida, K. (2004). Progestins’ actions in the VTA to facilitate lordosis involve
dopamine-like Type 1 and 2 Receptors. Pharmacology, Biochemistry, and Behavior 78, 405-418.
100. Frye, C.A., Walf, A.A., Rhodes, M.E., & Harney, J.P. (2004). Progesterone enhances motor, anxiolytic,
analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5-reductase. Brain
Research 1004, 116-124.
99. Petralia, S.M. & Frye, C.A. (2004). In the ventral tegmental area, G-proteins and cAMP mediate 3α,5α-THP’s
actions at dopamine type 1 receptors for lordosis of rats. Neuroendocrinology 80, 233-43.
98. Rhodes, M.E. & Frye, C.A. (2004). Progestins in the hippocampus of female rats have anti-seizure effects in a
pentylenetetrazole seizure model. Epilepsia 45, 1531-8.
97. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Kelly, K.M., Farina, E.L., &
Frye, C.A. (2004). Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men
with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs.
Epilepsia 45, 764-8.
96. Rhodes, M.E. & Frye, C.A. (2004). Estrogen has mnemonic enhancing effects in the inhibitory avoidance
task. Pharmacology, Biochemistry, & Behavior 78, 551-558.
95. Rhodes, M.E., Harney, J.P., & Frye, C.A. (2004). Gonadal, adrenal, and neuroactive steroids’ role in ictal
activity. Brain Research 1000, 8-18.
94. Rhodes, M.E., McCormick, C.M., & Frye, C.A. (2004). 3,5-THP mediates progestins' effects to protect
against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacology,
Biochemistry, & Behavior 78, 505-512.
93. Walf, A.A., Rhodes, M.E., & Frye, C.A. and (2004). Anti-depressant effects of ER selective estrogen
receptor modulators in the forced swim test. Pharmacology, Biochemistry, & Behavior 78, 483-493.
92. Frye, C.A. & Wawrzycki, J. (2003). Effect of prenatal stress and gonadal hormone condition on depressive
behavior of female and male rats. Hormones and Behavior 44, 319-326.
91. Frye, C.A. & Seliga, A.M. (2003).Effects of olanzapine infusions to the VTA on lordosis and midbrain 3,5THP concentrations in rats. Psychopharmacology 170, 132-139.
90. Frye, C.A., Petralia, S.M., Rhodes, M.E., & Stein, B. (2003). Fluoxetine may influence lordosis of rats
through effects on midbrain 3,5-THP concentrations. Annals of the New York Academy of Science 1007, 37-41.
89. Walf, A.A. & Frye, C.A. (2003). Anti-nociception following exposure to trimethylthiazoline, peripheral or
intra-amygdala estrogen and/or progesterone. Behavioural Brain Research 144, 77-85.
88. Frye, C.A. & Seliga, A.M. (2003). Olanzapine's effects to reduce fear and anxiety and enhance social
interactions coincide with increased progestin concentrations of ovariectomized rats. Psychoneuroendocrinology
28, 657-673.
87. Frye, C.A. & Petralia, S.M. (2003). Mitochondrial benzodiazepine receptors in the ventral tegmental area
modulate sexual behaviour of cycling or hormone-primed hamsters. Jounral of Neuroendocrinology 15, 677-686.
86. Frye, C.A. & Petralia, S.M. (2003). Lordosis of rats is modified by neurosteroidogenic effects of membrane
benzodiazepine receptors in the ventral tegmenal area. Neuroendocrinology 77,71-82.
85. Herzog, A.G. & Frye, C.A. (2003). Seizure exacerbation associated with inhibition of progesterone
metabolism. Annals of Neurology 53, 390-391.
84. Frye, C.A. & Rhodes, M.E. (2003). Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction
produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters. Neuropsychopharmacology 28, 310316.
83. Frye, C.A. & Rhodes, M.E. (2002). Enhancing effects of estrogen on inhibitory avoidance performance may
be in part independent of intracellular estrogen receptors in the hippocampus. Brain Research 956, 285-293.
82. Frye, C.A., Rhodes, M.E., Walf, A., & Harney, J.P. (2002). Testosterone enhances aggression in wild type
mice but not mice deficient in Type I 5-reductase. Brain Research 948, 165-170.
81. Frye, C.A. & Orecki, Z.A. (2002). Prenatal stress alters reproductive responses of rats in behavioral estrus and
paced mating of hormone-primed rats. Hormones and Behavior 42, 472-483.
80. Frye, C.A., Rhodes, M.E., Rosellini, R. & Svare, B. (2002). The nucleus accumbens as a site of action for
rewarding properties of testosterone and its 5-reduced metabolites. Pharmacology, Biochemistry, & Behavior 74,
119-127.
79. Freeman, E.W., Frye, C.A., Rickels, K., Martin, P.A.G. & Smith S.S. (2002). Allopregnanolone levels and
symptom improvement in severe premenstrual syndrome. Journal of Clinical Psychopharmacology 22, 516-20.
78. Seliga, A. & Frye, C.A. (2002). Olanzapine and progesterone dose-dependent and additive effects to enhance
lordosis and progestin concentrations of rats. Physiology and Behavior 76, 151-158.
77. Schmitz, C., Rhodes, M.E., Bludau, M., Kaplan, S., Ong, S., Ueffing, I., Vehoff, J., Korr, H. & Frye, C.A.
(2002). Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to
prenatal restraint stress. Molecular Psychiatry 7, 810-813.
18
76. McCormick, C.M., Kehoe, P., Mallinson, K., Cecchi, L., & Frye, C.A. (2002). Neonatal isolation alters stress
hormone and mesolimbic dopamine release in juvenile rats. Pharmacology, Biochemistry, and Behavior 73, 7785.
75. Frye, C.A. & Orecki, Z. (2002). Prenatal stress producing deficits in socio-sexual behavior of cycling, but not
hormone-primed, Long-Evans rats. Pharmacology, Biochemistry, and Behavior 73, 53-60.
74. Frye, C.A., Rhodes, M.E., Walf, A.A., and Harney, J. (2002). Progesterone reduces pentylenetetrazol-induced
ictal activity of wild type mice but not those deficient in Type I 5-reductase. Epilepsia 43, 14-17.
73. Frye, C.A. & Walf, A.A. (2002). Changes in progesterone metabolites in the hippocampus can modulate open
field and forced swim test behavior of proestrous rats. Hormones and Behavior 41(3), 306-315.
72. Anderson, D. A., Shapiro, J. R., Lundgren, J. D., Spataro, L. E., & Frye, C. A. (2002). Self-reported dietary
restraint is associated with elevated levels of salivary cortisol. Appetite 38, 13-17.
71. Frisone, D.F., Frye, C.A. & Zimmerberg B. (2002). Social isolation stress during the third week of life has
age-dependent effects on spatial learning in rats. Behavioral Brain Research 128, 153-160.
70. Rosellini, R.A., Rhodes, M.E., Svare, B.B. & Frye, C.A. (2001). The testosterone metabolite and neurosteroid
3-Androstanediol may mediate the effects of testosterone on conditioned place preference. Brain Research
Reviews, 37, 162-171.
69. Frye, C.A. (2001). The role of neurosteroids and non-genomic effects of progestins and androgens in
mediating sexual receptivity of rodents. Brain Research Reviews, 37, 201-222.
68. Frye, C.A. (2001). The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental
area in mediating sexual receptivity of rodents. Hormones and Behavior, 40, 226-233.
67. Frye, C.A. & Seliga, A.M. (2001). Testosterone increases analgesia, anxiolysis, and cognitive performance of
male rats. Cognitive and Affective Behavioral Neuroscience 1, 371-381.
66. Frye, C.A. & Vongher, J.M. (2001). Ventral tegmental area infusions of inhibitors of the biosynthesis and
metabolism of 3,5-THP attenuate lordosis of hormone-primed and behavioral oestrous rats and hamsters.
Jounral of Neuroendocrinology 13, 1076-1086.
65. Frye, C.A., Rhodes, M.E., Walf, A.A., & Harney, J.P. (2001). Testosterone reduces pentylenetetrazoleinduced ictal activity in wild type mice but not those deficient in Type I 5-reductase. Brain Research 918, 182186.
64. Rhodes, M.E. & Frye, C.A. (2001). Inhibiting progesterone metabolism in the hippocampus of rats in
behavioral estrous decreases anxiolytic, and enhances exploratory and anti-nociceptive behaviors. Cognitive and
Affective Behavioral Neuroscience 1, 287-296.
63. Frye, C.A. & Vongher, J.M. (2001). Progesterone and 3,5-THP enhance sexual receptivity in mice.
Behavioral Neuroscience 115, 1118-1128.
62. Altemus,M., Redwine, L.S., Leong, Y.M., Frye, C.A., Porges, S.W., & Carter, C.S. (2001). Responses to
laboratory psychosocial stress in post-partum women. Psychosomatic Medicine 63, 814-821.
61. Frye, C.A. & Muscatiello, N.A. (2001). 3,5-THP in the raphe magnus attenuates PTZ-induced myoclonic
seizures. Brain Research 911, 146-151.
60. Frye, C.A., Park, D., Tanaka, M., Rosellini, R., & Svare, B. (2001). The testosterone metabolite and
neurosteroid 3-androstanediol may mediate the effects of testosterone on conditioned place preference.
Psychoneuroendocrinology 26, 731-750.
59. Frye, C.A. & Lacey, E.H. (2001). Posttraining androgens’ enhancement of cognitive performance is
temporally distinct from androgen’ increases in affective behavior. Cognitive and Affective Behavioral
Neuroscience 1, 172-182.
58. Frye, C.A. (2001). Inhibition of 5-reductase enzyme or GABA(A) receptors in the VMH and the VTA
attenuates progesterone-induced sexual behavior in rats and hamsters. Journal of Endocrinological Investigation,
24, 399-407.
57. Frye, C.A. (2001). Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male rats
and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats. Brain Research 889,
358-363.
56. Kehoe, P., Mallinson, K., McCormick, C.M. & Frye, C.A. (2000). Central allopregnanolone is increased in rat
pups in response to repeated, short episodes of neonatal isolation. Developmental Brain Research 124, 133-136.
55. Frye, C.A. & Lacey, E.H. (2000). Progestins influence performance on cognitive tasks independent of changes
in affective behavior. Psychobiology 28, 550-563.
54. Frye, C.A., Manjarrez, J., & Camacho-Arroyo, I. (2000). Infusion of 3,5-THP to the pontine reticular
formation attenuates PTZ-induced seizures. Brain Research 881, 98-102.
53. Frye, C.A., Petralia, S.M., & Rhodes, M.E. (2000). Estrous cycle and sex differences in performance on
anxiety tasks coincide with increases in hippocampal progesterone and 35-THP. Pharmacology, Biochemistry,
and Behavior 67, 587-596.
52. Frye, C.A., Murphy, R.E., & Platek, S.M. (2000). Anti-sense oligonucleotides, for progestin receptors in the
VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats.
Behavioral Brain Research 115, 55-64.
51. Bitran, D., Foley, M., Audette, D., Leslie, N. & Frye, C.A. (2000). Activation of peripheral mitochondrial
benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like
effects in the rat. Psychopharmacology 151, 64-71.
50. Frye, C.A. & McCormick, C.M. (2000). Androgens are neuroprotective in the dentate gyrus of
adrenalectomized female rats. Stress 3, 185-194.
49. Frye, C.A., Bayon, L.E. & Vongher, J.M. (2000). Intravenous progesterone elicits a more rapid induction of
lordosis in rats than does SKF38393. Psychobiology 28, 99-109.
48. Frye, C.A. & Scalise, T.J. (2000). Anti-seizure effects of progesterone and 3,5 -THP in kainic acid and
perforant pathway models of epilepsy. Psychoneuroendocrinology 25, 407-420.
47. Frye, C.A. & McCormick, C.M. (2000). The neurosteroid, 3-Androstanediol, prevents inhibitory avoidance
deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Brain
Research 855, 166-170.
46. Kelsey, J.E., Sanderson, K.L., & Frye, C.A. (2000). Perforant path stimulation in rats produces seizures, loss
of hippocampal neurons, and a deficit in spatial mapping which is reduced by prior MK-801. Behavioral Brain
Research 107, 59-69.
45. Vongher, J.M. & Frye, C.A. (1999). Progesterone in conjunction with estradiol has neuroprotective effects in
an animal model of neurodegeneration. Pharmacology, Biochemistry and Behavior 64, 777-785.
44. Frye, C.A. & Bayon, L.E. (1999). Mating stimuli influence endogenous variations in the neurosteroids 3,5THP and 3-Diol. Journal of Neuroendocrinology 11, 839-847.
43. Frye, C.A. & Vongher, J.M. (1999). Progestins’ rapid facilitation of lordosis when applied to the ventral
tegmentum corresponds to efficacy at enhancing GABAA receptor activity. Journal of Neuroendocrinology 11,
829-837.
42. Frye, C.A. & Vongher, J.M. (1999). GABAA, D1, and D5, but not progestin receptor, antagonist and anti-sense
oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis. Behavioral
Brain Research, 103, 23-34.
20
41. Frye, C.A. & Vongher, J.M. (1999). 3,5-THP in the midbrain ventral tegmental area of rats and hamsters is
increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. Journal of
Endocrinological Investigation 22, 455-464.
40. Kellogg, C.K. & Frye, C.A. (1999). Endogenous levels of 5-reduced progestins and androgens in fetal vs.
adult rat brains. Developmental Brain Research 115, 17-24.
39. Frye, C.A. & Lacey, E.H. (1999). The neurosteroids DHEA and DHEAS may influence cognitive
performance by altering affective state. Physiology & Behavior 66, 85-92.
38. Wilson, M.A. & Frye, C.A. (1999). Effects of chronic benzodiazepine exposure on stress-induced neuroactive
steroid levels. Brain Research 824, 136-139.
37. Frye, C.A. & Bayon, L.E. (1999). Prenatal stress reduces the effectiveness of the neurosteroid 3,5-THP to
block kainic-acid-induced seizures. Developmental Psychobiology 34, 227-234.
36. Morgan, K.N., Thayer, J.E. & Frye, C.A. (1999). Prenatal stress suppresses rat pup ultrasonic vocalization
and myocolonic twitching in response to separation. Developmental Psychobiology 34, 205-215.
35. Frye, C.A. & Vongher, J.M. (1999). Progesterone has rapid and membrane effects in the facilitation of female
mouse sexual behavior. Brain Research 815, 259-269.
34. Frye, C.A. & Bayon, L.E. (1999). Cyclic withdrawal from endogenous and exogenous progesterone increases
kainic acid and perforant pathway induced seizures. Pharmacology, Biochemistry and Behavior 62, 315-321.
33. Frye, C.A., Bayon, L.E., Pursnani, N. & Purdy, R.H. (1998). The neurosteroids, progesterone and 3,5THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Research 808, 72-83.
32. Dunn, R.W., Reed, T.A.W., Copeland, P.D. & Frye, C.A. (1998). The nitric oxide synthase inhibitor 7nitroindazole displays enhanced anxiolytic efficacy without tolerance in rats following subchronic administration.
Neuropharmacology 37, 899-904.
31. Frye, C.A. & Bayon, L.E. (1998). Seizure activity is increased in endocrine states characterized by decline in
endogenous levels of the neurosteroid 3,5-THP. Neuroendocrinology 68, 272-280.
30. Smith, S.S., Gong, Q.H., Li, X., Moran, M.H., Bitran, D., Frye, C.A. & Hsu, F.C. (1998). Withdrawal from
3-OH-5-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated
current and increases the GABAA receptor 4 subunit in association with increased anxiety. Journal of
Neuroscience 18, 5275-5284.
29. Frye, C.A. & Reed, T.A. (1998). Androgenic neurosteroids: anti-seizure effects in an animal model of
epilepsy. Psychoneuroendocrinology 23, 385-399.
28. Frye, C.A., Scalise, T.J. & Bayon, L.E. (1998). Finasteride blocks the reduction in ictal activity produced by
exogenous estrous cyclicity. Journal of Neuroendocrinology 10, 291-296.
27. Bitran, D., Hilvers, R.J., Frye, C.A. & Erskine, M.S. (1996). Chronic anabolic-androgenic steroid treatment
affects brain GABAA receptor-gated chloride ion transport. Life Sciences 58, 573-583.
26. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Progesterone and 3-Androstanediol
conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA. Behavioral
Neuroscience 110, 603-612.
25. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Analgesic effects of the neurosteroid 3Androstanediol. Brain Research 709, 1-9.
24. Frye, C.A., McCormick, C.M., Coopersmith, C. & Erskine, M.S. (1996). Effects of paced and non-paced
mating stimulation on plasma progesterone, 3-Diol and corticosterone. Psychoneuroendocrinology 21, 431-439.
23. Frye, C.A., Duncan, J.E., Basham, M. & Erskine, M.E. (1996). Behavioral effects of 3-Androstanediol II:
Hypothalamic and preoptic area actions via GABAergic mechanism. Behavioral Brain Research 79, 119-130.
22. Frye, C.A., Van Keuran, K.R. & Erskine, M.S. (1996). Behavioral effects of 3-Androstanediol I:
modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behavioral Brain Research
79, 109-118.]
21. Frye, C.A. & Gardiner, S.G. (1996). Progestins can have a membrane-mediated action in rat midbrain for
facilitation of sexual receptivity. Hormones and Behavior 30, 682-691.
20. Frye, C.A. & Duncan, J.D. (1996). Estradiol benzoate potentiates neuroactive steroids' effects on pain
sensitivity. Pharmacology, Biochemistry and Behavior 53, 27-32.
19. Frye, C.A. (1995). The neurosteroid 3,5-THP has antiseizure and possible neuroprotective effects in an
animal model of epilepsy. Brain Research 696, 113-120.
18. Crystal, S., Frye, C.A. & Kanarek, R.B. (1995). Taste preferences and sensory perceptions in female varsity
swimmers. Appetite 24, 25-36.
17. Frye, C.A. & Sturgis, J.D. (1995). Neurosteroids affect spatial/reference, working, and long-term memory of
female rats. Neurobiology of Learning and Memory, 64, 83-96.
16. Frye, C.A. (1995). Estrus-associated decrements in a water maze task are limited to acquisition. Physiology
& Behavior, 57, 5-14.
15. DeBold, J.F. & Frye, C.A. (1994). Genomic and non-genomic actions of progesterone in the control of female
hamster sexual behavior. Hormones and Behavior 28, 445-453.
14. DeBold, J.F. & Frye, C.A. (1994). Progesterone and the neural mechanisms of hamster sexual behavior.
Psychoneuroendocrinology 19, 563-579.
13. Frye, C.A., Crystal, S., Ward, K.D. & Kanarek, R.B. (1994). Menstrual cycle and dietary restraint influence
taste preferences in young women. Physiology & Behavior 55, 561-567.
12. Frye, C.A. & Weisberg, R.B. (1994). Increasing the incidence of routine pelvic examinations: Behavioral
Medicine's contribution. Women and Health 21, 33-55.
11. Frye, C.A. & Leadbetter, E.A. (1994). 5-reduced progesterone metabolites are essential in hamster VTA for
sexual receptivity. Life Sciences 54, 653-659.
10. Frye, C.A. & Duncan, J.E. (1994). Progesterone metabolites, effective at the GABAA receptor complex,
attenuate pain sensitivity in rats. Brain Research 643, 194-203.
9. Frye, C.A. & DeMolar, G. (1994). Menstrual cycle and sex differences influence salt preference. Physiology &
Behavior 55, 193-197.
8. Frye, C.A., Mermelstein, P.G. & DeBold, J.F. (1993). Bicuculline infused into the hamster ventral tegmentum
inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacology, Biochemistry and Behavior 46, 1-8
7. Frye, C.A., Cuevas, C.A. & Kanarek, R.B. (1993). Diet and estrous cycle influence pain sensitivity in rats.
Pharmacology, Biochemistry and Behavior 45, 255-260.
6. Frye, C.A. & DeBold, J.F. (1993). 3-OH-DHP and 5-THDOC implants to the ventral tegmental area
facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus. Brain
Research 612, 130-137.
5. Frye, C.A. & DeBold, J.F. (1993). P-3-BSA, but not P-11-BSA, implants in the VTA rapidly facilitate
receptivity in hamsters after progesterone priming to the VMH. Behavioral Brain Research 53, 167-175.
4. Frye, C.A., Mermelstein, P.G., & DeBold, J.F. (1992). Evidence for a non-genomic action of progestins on
sexual receptivity in hamster ventral tegmental area but not hypothalamus. Brain Research 578, 87-93. [
3. Frye, C.A., Bock, B.C. & Kanarek, R.B. (1992). Hormonal milieu affects tailflick latency in female rats and
may be attenuated by access to sucrose. Physiology & Behavior 52, 699-706.
22
2. Frye, C.A. & DeBold, J.F. (1992). Muscimol facilitates sexual receptivity in hamsters when infused into the
ventral tegmentum. Pharmacology, Biochemistry & Behavior 42, 879-887.
1. Frye, C.A. & Erskine, M.S. (1990). Influence of time of mating and paced copulation on induction of
pseudopregnancy in cyclic female rats. Journals of Reproduction and Fertility 90, 375-385.
BOOK CHAPTERS & EDUCATIONAL REPORTS
32. Kohtz, A.S., Frye, C.A. (2011). Dissociating behavioral, autonomic, and neuroendocrine effects of androgen
steroids in animal models. In: Psychiatric Disorders: Methods and Protocols, Editor: Firas Kobeissy, Ph.D., (in
press). Springer.
31. Frye, C.A., Llaneza, D.C. (2011). The role of 3α-hydroxy-5α-pregnan-20-one in mediating the development
and/or expression of schizophrenia spectrum disorders: Findings in rodent models and clinical populations. In:
Brain Protection in Schizophrenia, Mood and Cognitive Disorders, Editor: Michael Ritsner, M.D., Ph.D., Vol 1,
367-404. Springer.
30. Walf, A.A., Frye, C.A. (2010). Using the elevated plus maze as a bioassay to assess the effects of naturallyoccuring, and exogenously-administered compounds, to influence anxiety-related behaviors of mice. In: Mood &
Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Editor: Todd Gould, M.D., 225246. Springer Protocols.
29. McLaughlin, J.P., Gomes, S., Seliga, A., Ramos-Goyette, S., Morrison, A., Reich, C.G., Frye, C.A. (2009).
Northeast Under/graduate Research Organization for Neuroscience (NEURON): our 13th conference for
neuroscience trainees and educators. CBE-Life Sciences Education. The American Society for Cell Biology, 8, 1113.
28. Frye, C.A. (2009). Neurosteroids-From Basic Research to Clinical Perspectives. In: Hormones/Behavior
Relations of Clinical Importance. Editors: Robert T. Rubin and Donald W. Pfaff, 395-416. San Diego: Academic
Press.
27. Frye, C.A. & Rhodes, M.E. (2009). Female sex steroids and neuronal excitability. In: Encyclopedia of Basic
Epilepsy Research.Volume 1. Editor: Phil Schwartzkroin, 477-484. Oxford: Academic Press.
26. Frye, C.A. & Rhodes, M.E. (2009). Male sex steroids and neuronal excitability. In: Encyclopedia of Basic
Epilepsy Research. Volume 1. Editor: Phil Schwartzkroin, 507-513. Oxford: Academic Press.
25. Frye, C.A. (2008). Hormonal influences on seizures: Basic neurobiology. In: Epilepsy in women-scientific
management. Editors: Barry Gidal and Cynthia Harding. International Review of Neurobiology, 83, 27-77.
24. Goyette, S.R., Edinger, K.L., Luine, V., Young, J., Frye, C.A. (2009). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): Our third New York City meeting. The Journal for Undergraduate
Neuroscience Education, 6: A14-A20.
23. Rhodes, M.E., Ramos, S.G., Young, J., Luine, V., Frye, C.A. (2008). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our twelfth annual conference for neuroscience trainees
and educators. Journal of Behavioral and Neuroscience Research, 6.
22. Frye, C.A., Rhodes, M.E. (2008). The role of midbrain 3α,5α-THP in mediating exploration, anxiety, social
and reproductive behavior In: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders:
Novel Strategies for Research and Treatment. Editors: Michael S. Ritsner and Abraham Weizman, 449-482, New
York, NY, US: Springer Science.
21. Rhodes, M.R., Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2007). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience trainees
and educators. Journal of Behavioral and Neuroscience Research, 5: 1-8.
20. Frye, C.A., Rhodes, M.E. (2007). The role and mechanisms of steroid hormones to enhance
approach/avoidance behavior. In: Handbook of approach and avoidance motivation. Editor: A. Elliot, 109-126,
Mahwah, NJ: LEA.
19. Frye, C.A., Rhodes, M.E. (2007). Reciprocal effects of exploration, anxiety, social, and sexual behaviors and
24
progestins in midbrain, hippocampus, diencephalon, and cortex In: Evolutionary Molecular Strategies and
Plasticity: Editors: Marcello Canonaco and Rosa Maria Facciolo, 237-260, Research Signpost.
18. Harden, C.L. & Frye, C.A. (2007). Hormone Changes in Epilepsy. In: Epilepsy: A Comprehensive Textbook,
Second Edition. Editors: Jerome Engel, M.D., Ph.D., Timothy A. Pedley, M.D., 2037-2042, Lippincott Williams
& Wilkins.
17. Rhodes, M.E., Edinger, K.L., Young, J., Luine, V., Frye, C.A. (2006). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience trainees
and educators. Journal of Behavioral and Neuroscience Research. 4:1-7.
16. Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2005). Northeast Under/graduate Research Organization for
Neuroscience (NEURON): An update on our ninth annual conference for neuroscience trainees and educators.
Journal of Behavioral and Neuroscience Research, 2, 1-7.
15. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds. (2005). Epilepsy
through the menstrual cycle: the truth about catamenial epilepsy. Neurology Supplement.
14. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds. (2005).
Correlations between hormone levels and seizure activity. Neurology Supplement.
13. Frye, C.A., Harden, C.L., Baker, G. A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds. (2005). Effects of
estrogen and progesterone on cortical excitations and epileptogenesis Neurology Supplement.
12. Frye, C.A., Edinger, K.L. (2004). Northeast Under/graduate Research Organization for Neuroscience
(NEURON): A regional neuroscience meeting for undergraduates, graduate students, and faculty. Journal for
Undergraduate Neuroscience Education, 2, 36-40.
11. Edinger, K.L., Morgan, K., Blasberg, M., Frye, C.A. (2004). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our eighth annual conference for neuroscience trainees
and educators. Journal of Behavioral and Neuroscience Research, 1, 1-8.
10. Blasberg, M.E., Morgan, K., Frye, C.A. (2003). The 7th annual conference on the Northeast Under/graduate
Research Organization for Neuroscience (NEURON). Journal of Behavioral and Neuroscience Research, 1:1-2.
9. Edinger, K.L., Morgan, K., Blasberg, M., Frye, C.A. (2003). Northeast Under/graduate Research Organization
for Neuroscience (NEURON): An update on our seventh annual conference for neuroscience trainees and
educators. Journal for Undergraduate Neuroscience Education. 1:1-8.
8. Frye, C. A., Petralia, S. M. (2003). 3,5-THP’s actions in the ventral tegmental area for lordosis: A model
system for defining function and mechanisms of progestins. In: Neurosteroids and the GABAA Receptor. Editor:
S. Smith, CRC Press, Boca Raton, FL.
7. Frye, C.A., Petralia, S.M. (2003). Progestins have actions through GABAA receptors, In: The Identities of
Membrane Steroid Receptors: And Other Proteins Mediating Nongenomic Steroid Action, Editor: C.S. Watson,
Kluwer Academic Publishers, Boston, MA.
6. Rhodes, M.E., Frye, C.A. (2002). Hormones influence cognitive performance, In: Forget it? -Sources,
Theories, and Mechanisms of Alterations in Mnemonic Function, Editor: R. Flint, Erudition Books, North
Chelmsford, MA, 175-196.
5. Frye, C.A., Weisberg, R.B., Hinkson, A.B. (2000). Anxiety and women's health. In: The management of stress
and anxiety in medical disorders, Editors: D.I. Mostofsky and D.H. Barlow, Allyn & Bacon, Needham, MA.
4. Frye, C.A. (2000). Integration of affiliation: Well done! Trends in Endocrinology and Metabolism, 11, 155157.
3. Frye, C.A. (2000). Neurosteroids: A new regulatory function in the Nervous System. The Quarterly Review of
Biology, 75, 349-350.
2. Smith, S.S., Hsu, F.C., Li, X., Frye, C.A., Faber, D.S., Markowitz, R.S. (2000). Oestrogen effects in olivocerebellar and hippocampal circuits. Neural and cognitive effects of oestrogens. Wiley, Chichester, 230, 155-172.
1. Frye, C.A. (1996). Investigation of stimuli eliciting displays in labyrinth fish: A simple behavioral assay useful
in teaching neuroscience. Neuroscience Methods: The Undergraduate Laboratory Experience, Trinity College
Press, Hartford, CT.
INVITED TALKS
Frye, C.A. (2011). Neurosteroids: Of, for, and by, the nervous system. Texas A&M University, College Station,
Texas.
Frye, C.A. (2011). The role of neurosteroids in motivated behaviors. Universite de Strasbourg, Strasbourg,
France.
Frye, C.A. (2011). The role of neuroactive steroids and depression. Neurex Workshop, Basel, Switzerland.
Frye, C.A. (2011). Pregnane xenobiotic receptors in the ventral tegmental area may mediate progestogenfacilitated reproductive behavior of female rats. Symposium presentation at the 6th International Meeting
Steroids and Nervous System. Torino, Italy.
Frye, C.A. (2011). Your brain and steroids: of, for, and by the nervous system. University of California, Santa
Barbara, California.
Frye, C.A. (2011). Effects and mechanisms of progestoens for object memory. Conference on Learning and
Memor, Park City, Utah.
Frye, C.A. (2010). Progestogens’ and estrogens’ social, affective, and cognitive function. Nova Southeastern
University & Ponce School of Medicine, Ponce, Puerto Rico.
Frye, C.A. (2010). Neurosteroids: Of, for, and by, the nervous system. Universidad del Este-SUAGM, Escuela de
Ciencias y Tecnologia, Carolina, Puerto Rico.
Frye, C.A. (2010). (Neuro)steroids of, for, and by the nervous system. Hudson-Berkshire Neuroscience Group,
Albany, NY.
Frye, C.A., Paris, J.J., Walf, A.A. (2010). The role if pregnane neurosteroid formation in reproductive endocrine
function and pregnancy. 4th International Parental Brain Meeting, Edinburgh, Scotland.
Frye, C.A. (2010) Protective effects of progesterone. 19th Annual Meeting, International Behavioral
Neuroscience Society, Sardinia, Italy.
Frye, C.A. (2010) Sex, Drugs & Rock ‘n’ Roll. Neurofest, SUNY Upstate Medical Universtiy, Syracuse NY.
Frye, C.A. (2010). Beneficial trophic effects in the brain relative to negative proliferative effects on peripheral
reproductive tissues. Window of Opportunity - Estrogen Workshop, Stanford, CA.
Frye, C.A. (2009). Sex, Drugs, Rock & Roll, The Role of Neurosteroids 17th New England Conference North/East
Under/graduate Research Organization for Neuroscience (N.E.U.R.O.N.), Boston Latin School, Boston, MA.
Giordano M., Caljouw, M., McCarthy, M., Scapicchio, P., Spillane, T., Frye, C.A. (2009). Doctors, Lawyers, &
Chiefs. Boston Latin School, Boston, MA.
Frye, C.A. (2009). Distinguished Graduate Award Talk. Boston Latin School Alumni Dinner, Boston, MA.
Frye, C.A. (2009). Neurodegenerative Disorders. Boston Latin School, Boston, MA
26
Frye, C.A. (2009). Progesterone: novel effects and mechanisms across the lifespan. Indiana State University,
Bloomfield, IN.
Frye, C.A. (2009). Sex differences in HPA-responding and the role of progestogens in adult expression and
development of stress responses. The State University of New York, School of Public Health, Albany, NY.
Frye, C.A. (2009). Neurosteroids’ effects and mechanisms for social, cognitive, emotional, and physical functions.
Arizona State Univeristy.
Frye, C.A. (2009). Progesterone and its metabolites in the pathophysiology and treatment of neuro-developmental,
psychiatric and/or developmental disorders. 11th Argentinean Congress of Neuropsychiatry Conference.
Argentina.
Frye, C.A. (2009). Estrogens, progestogens and androgens… oh my: effects and mechanisms for depression.
International Society for Psychoneuroendocrinology Conference 2009. San Franscisco, California.
Walf, A.A. & Frye, C.A. (2009). Estradiol’s actions through estrogen receptor β for functional effects in
hippocampus-mediated behaviors, but not uterine proliferation or carcinogen-induced tumorigenesis.
International Behavioral Neuroscience Society, 18th Annual Meeting, Nassau, Bahamas.
Frye, C.A., Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Forsyth, J.P., Anderson, D.A., Wulfert E. (2009).
Sex differences in stress hormone response are not always male-biased in panic disorder symptomology,
posttraumatic stress disorder, & pathological gambling. Satellite symposium presentation at the 5th
International Meeting Steroids and Nervous System. Torino, Italy.
Frye, C.A., Llaneza, D.C., Paris, J.J. (2009). Activational and organizational effects of progesterone for affective
and cognitive behavior due to 5-pregnan-3-ol-20-one. Symposium presentation at the 5th International
Meeting Steroids and Nervous System. Torino, Italy.
Frye, C.A. (2009). ERβ is a target for beneficial trophic effects of estrogens in females, and androgens in males, in
brain but not reproductive tissue. New York Medical College. New York, NY.
Frye, C.A. (2009). Sex, drugs, and rock n’ roll: the role of neurosteroids. Northeastern University.
Frye, C.A., Llaneza, D.C., Paris, J.J. (2009) Activational and organizational effects of progesterone for affective
and cognitive behavior due to 5α-pregnan-3α-ol-20-one. Conference on Steroids and the Nervous System.
Torino, Italy.
Paris J.J., Frye C.A. (2009) Formation of 3α-androstanediol may underlie alcoholpromoted aggression among
rodents. Conference on Steroids and the Nervous System. Torino, Italy.
Frye, C.A. (2008). The role of actions at the β isofrom of the estrogen receptor in mediating affective behavior.
International Congress of Neuropsychiatry, Cancun, Mexico.
Walf, A.A., Frye, C.A. (2008). ER may be a novel target for the beneficial effects of naturally-occurring steroids,
therapeutics, and selective estrogen receptor modulators. International Drug Discovery Science and
Technology, Beijing, China.
Frye, C.A., Walf, A.A. (2008). ER may be a novel target for the beneficial effects of estrogens in females, and
androgens in males, for anxiety, depression, and cognitive function. Ehrlich II- 2nd World Conference on
Magic Bullets, Nurnberg, Germany.
Frye, C.A. (2008). Progesterone… it’s not just for pregnancy. Louisiana State University, Shreveport, LA.
Frye, C.A. (2008). Enhancing children’s neural and cognitive development through reading. Delaware Community
School, Albany, NY.
Frye, C.A. (2008). The role of actions at ERβ in beneficial effects of estrogens and progestins. Organization for
the study of sex differences conference, New Orleans, LA.
Frye, C.A. (2008). The role of neurosteroids and actions at ERβ for physical and psychology effects of hormone
therapies. Wyeth Pharmaceuticals, Collegeville, PA.
Frye, C.A. (2008). Progestogens...of, for, and by the nervous system are not just for pregnancy. Drexel University
Medical School, Pharmacology Department, Philadelphia, PA.
Frye, C.A. (2008). Steroid hormones in mental health and disease. International Congress of Neuropsychiatry,
Cancun Mexico
Frye, C.A., Walf, A.A. (2008). Estrogen receptor β as a target for the anti-anxiety and anti-depressant effects of
steroids Conference of The Society for The Study of Sex Diffferences, New Orleans, LA.
Frye, C.A., (2008). Functional effects of neurosteroids-hormones that are of the nervous
system, by the nervous system, and for the nervous system. Albert Einstein School of Medicine, Bronx, NY
Frye, C.A., (2007). Estrogen receptor β as a target for steroids’ effects on affective and cognitive behavior. Annual
Graylyn Conference on Women's Cognitive Health, Wake Forest, NC.
Frye, C.A., (2007). Progestins actions in the midbrain to enhance lordosis involve GABA, dopamine and
glutamate receptors and their downstream signal transduction factors. Conference on Rapid Response
Signaling of Steroid Hormones, Dublin, Ireland.
Frye, C.A., (2007). Neurosteroids- Of the nervous system, by the nervous system, for the nervous system.
Skidmore College, Saratoga Springs, NY.
Frye, C.A., Walf, A.A. (2007). Actions at estrogen receptor  may underlie some of the anti-anxiety, antidepressant, and memory enhancing effects of steroids. Conference on Steroids and the Nervous System.
Torino, Italy.
Frye, C.A.(2007). The global impact of behavioral endocrinology-hormones across the world.. Conference on
Steroids and the Nervous System. Torino, Italy.
Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Inhibition of 3,5-THP formation decreases exploratory/anti-anxiety
and socio-sexual behavior in sexually receptive female rats. Conference on Steroids and the Nervous System.
Torino, Italy.
Frye, C.A., Paris, J.J. (2006). 3-androstanediol may underlie some of testosterone’s positive hedonic and/or drugrelated effects. International Society for Biomedical Research on Alcoholism -World Congress on Alcohol
Research, Sydney, Australia.
Frye, C.A., Walf, A.A. (2006). Anti-anxiety and anti-depressant effects of steroids with actions at estrogen
receptor . 37th Annual International Society for Psychoneuroendocrinology (ISPNE) meeting. Leiden,
Netherlands.
Frye, C. A. (2006). Effects of pre-natal manipulations on response to stress during development and in adulthood.
Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders,
Morzine, France.
Frye, C.A. (2006). Rewarding effects of progestins: Importance for drug abuse. Pharmacology, Biochemistry and
Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France.
Rhodes, M.E., Frye, C.A. (2006). Rewarding effects of androgen: Importance for drug abuse. Pharmacology,
Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France.
28
Walf, A.A., Frye, C.A. (2006). Antidepressant-like effects of estrogen receptor modulators after short-term
treatment. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.
Walf, A.A., Rhodes M.E., Frye, C.A. (2006). Rewarding effects of estrogen: Importance for drug abuse.
Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.
Frye, C.A. (2005). Ovarian hormones in animal models of catamenial epilepsy. Special Interest Group – Animal
Models of Catamenial Epilepsy at the American Epilepsy Society Meeting, Washington, DC.
Frye, C.A. (2005). Differential behavioral effects of estradiol through ER and ER. National Academy of
Sciences of the Czech Republic, Prague, Czech Republic.
Frye, C.A. (2005). Role of progesterone in animal models of schizophrenia. Prague Center for Psychiatry, Prague,
Czech Republic.
Petralia, S. M., Sumida, K., & Walf, A. A., Frye, C. A. (2005). Progestin-facilitated sexual behavior of female rats
may involve activity of adenylyl cyclase in the ventral tegmental area (VTA). International Conference on
Steroids and the Nervous System, Torino, Italy.
Rhodes, M. E., Petralia, S.M., Jahagirdar, V., & Frye, C. A. (2005). Actions of the neurosteroids, 3, 5-THP, in
the ventral tegmental area, mediate socio-sexual behaviors. International Conference on Steroids and the
Nervous System, Torino, Italy.
Frye, C.A. & Rhodes, M.E. (2004). Ovarian hormones and their effects on cortical excitation and influences on
epileptogenesis. Women and Epilepsy Advisory Board, Atlanta, GA.
Frye, C.A. (2004). Sex differences in rats: anxiety responses to androgens, Pharmacology, Biochemistry and
Behavior Conference, Morzine, France.
Frye, C.A. & Rhodes, M.E. (2003). Androgens and seizures. American Epilepsy Society Conference, Boston, MA.
Frye, C.A. (2003). Novel actions of steroid hormones- basic and clinical research. Marywood University, Scranton,
PA.
Frye, C.A. (2003). Membrane actions of hormones and the relationship to function. Marywood University,
Scranton, PA.
Frye, C.A. (2003). Approaches to enhance training of neuroscience. International Brain Research Organization,
Prague, CZ.
Frye, C.A. (2003). Sex and hormonal differences in response to gestational stress. TENNET Conference, Montreal,
CANADA.
Frye, C.A. (2003). The functional role of neurosteroids. CUNY-Park Avenue Colloquium, New York City, NY.
Frye, C.A., Petralia, S., & Rhodes, M.E. (2003). Fluoxetine’s effects on sexual function may involve
allopregnanolone in the ventral tegmental area. International Conference on Steroids and the Nervous System,
Torino, Italy.
Frye, C.A. (2003). Non-ER mediated effects of estrogen on learning and memory. Experimental Biology Meeting,
San Diego, CA.
Frye, C.A. & Rhodes, M.E. (2003). Estrogen may have genomic and non-genomic actions in the dorsal
hippocampus to improve inhibitory avoidance performance. Twenty-seventh Annual Winter Conference on the
Neurobiology of Learning & Memory at Park City, Park City, UT.
Frye, C.A. (2002). The role of non-genomic actions of steroids in mediating reproductive, affective and cognitive
behaviors. CUNY-Brooklyn, Psychology Department Colloquia.
Frye, C.A. (2002). Mating-induced neurosteroidogenesis in the hippocampus induces anxiolysis of female rats.
Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. & Epperson, N. (2002). Neurosteroid modulation of -Aminobutyric Acid neuronal function: Clinical
implications. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Herzog, A.G., Frye, C.A., Drislane, F.W., Friedman, M.N., & Schomer, D.L. (2001). Neuroactive reproductive
steroid changes in men with epilepsy: associations with sexual function and potential implications for
neuronal excitability. American Epilepsy Society Conference, Philadelphia, PA.
Frye, C.A. (2001). Non-genomic actions of steroid hormones mediate social, affective, and cognitive behavior
American College of Neuropsychopharmacology. Waikoloa, Hawaii.
Frye, C.A. (2001). Developing Programs in Neuroscience at the Small College and University, NSF Sponsored
Project Kaleidoscope Workshop on “Neuroscience Education: From the Enchanted Loom to the World Wide
Web”, Hartford, Connecticut.
Frye, C.A. (2001). North East Undergraduate Research Organization for Neuroscience (N.E.U.R.O.N.), A regional
program to promote training in Neuroscience Undergraduate. NSF Sponsored Project Kaleidoscope Workshop
on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, Connecticut.
Frye, C.A. (2001). Distinguishing allopregnanolone’s effects on anxiety from other behaviors. American
Neuroendocrine Society Conference, Breckenridge, Co.
Frye, C.A. (2001). Neurosteroids and anxiety. Symposium Organizer and Chair, American Neuroendocrine
Society Conference, Breckenridge, Co.
Frye, C.A. (2001). Neurosteroids actions in modulating reproductive and non-reproductive behavior.
Neuroscience Symposium Series, Brigham Young University, Provo, Utah.
Frye, C.A. & Muscatiello, N. (2001). The mechanism of action of progestins’ anti-seizure effects in the hindbrain.
Workshop on the Neurobiology of Epilepsy, Iguazu, Brazil.
Frye, C.A. (2001). 3,5-THP in the raphe nucleus and pontine reticular formation attenuate myoclonic and tonic
clonic seizures. Spring Epilepsy Research Conference, Grand Cayman, BWI.
Frye, C.A. (2001). Assessing factors which influence anti-seizure effects of neurosteroids: Integration of basic and
clinical research. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (2001). The role of NMDA receptors in the VTA in mediating progestin-facilitated sexual receptivity.
Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (2001). How do steroids mitigate sex, anxiety, learning and memory, and brain damage? LaDonne
Heaton Schulman Endowed Lecture, Wheaton College, Norton, MA.
Frye, C.A. (2001). The role of androstane neurosteroids in mediating reproductive and non-reproductive behavior.
Neuroendocrinology Colloquium Series, The University of Milan, Italy.
Frye, C.A. (2001). Factors which influence sexual differentiation by environmental endocrine disruptors-using
reproductive and non-reproductive behavior as indicators. The Department of Animal Sciences, The
University of Florence, Italy.
Frye, C.A. (2001). Neurosteroids in the Ventral Tegmental Area mediate sexual receptivity in rodents.
International Conference on Steroids and the Nervous System, Torino, Italy.
Frye, C.A. (2000). Two interactive exercises which engage students to learn about the brain. Eastern Section Siena
State Teachers’ Conference, Albany, NY.
30
Frye, C.A. (2000). What can progesterone’s actions for sex behavior in rodents tell us about neural substrates for
learning and memory, anxiety and neuroprotection in people? The College of Saint Rose, Albany, NY.
Frye, C.A. (2000). Neurosteroids mediate the onset and duration of sexual receptivity in rodents. Society for
Behavioral Neuroendocrinology, Madrid, Spain.
Frye, C.A. (2000). Neurosteroids …Of the Nervous system, by the Nervous System and for the Nervous System.
Society for Behavioral Neuroendocrinology, Madrid, Spain
Frye, C.A. , Rhodes, M.E., Spataro, L.E. (2000). The role of neurosteroids in the Ventral Tegmental Area in
mediating sexual receptivity in rodents. Society for Behavioral Neuroendocrinology, Madrid, Spain.
Frye, C.A., Petralia, S., & Rhodes, M.R. (2000). Sex and estrous cycle differences in performance on anxiety
tasks coincide with increases in hippocampal progesterone and 3,5-THP. Biological Basis of Sexual
Orientation, Sex Identity, and Gender-Typical Behavior. Minot, North Dakota.
Frye, C.A. (1999). Non-genomic actions of progestins on cognitive and affective behavior in rodents. The keynote
address for National Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.
Frye, C.A. (1999). Non-genomic actions of progesterone in the VTA-effects on sexual receptivity. National
Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.
Frye, C.A. & J.M. Vongher. (1999). The role of 3,5-THP in progesterone’s facilitation of sexual receptivity in
mice. International Behavioral Neuroscience Conference, Nancy, France.
Frye, C.A. (1999). Neurosteroids role in progestins' anti-seizure effects. Spring Epilepsy Research Conference,
Grand Cayman, BWI.
Frye, C.A. (1999). Neurosteroids & behavior. European Winter Conference on Brain Research, Aime, France.
Frye, C.A. (1999). The role of neurosteroids in social behavior. European Winter Conference on Brain Research,
Aime, France.
Frye, C.A. (1999). Non-genomic actions of steroid hormones...functional consequences. Hudson-Berkshire
Neuroscience Group, Albany, New York.
Frye, C.A. (1998). Progestins mediate reproductive and non-reproductive behavior. The University at AlbanySUNY, Albany, NY.
Frye, C.A. (1998). Neurosteroids mediate sexual, cognitive, and affective behavior. Emory University, Atlanta,
GA.
Frye, C.A. (1998). The role of steroid hormones in neurodegenerative disorders. Centenary College/Louisiana
State University, Shreveport, LA.
Frye, C.A. (1998). Progesterone’s mechanism of action. Georgia State University, Atlanta, GA.
Frye, C.A. (1998). Neurosteroids and motivated behavior. Florida State University, Gainesville, FL.
Frye, C.A. (1997). Progestins role in epilepsy. Epilepsy Foundation of America Regional Meeting. Darien, CT.
Frye, C.A. (1997). Non-genomic effects of progesterone - Implications for PMS, Epilepsy and Alzheimer’s
Disease. Rutgers University, Camden, NJ.
Frye, C.A. (1996). Neurosteroids role in reproductive and non-reproductive behavior. University of Southern
Florida, Tampa, FL.
Frye, C.A. (1996). Alzheimer’s disease: a focus on effects of hormones. Alleghany College, Alleghany, PA.
Frye, C.A. (1996). Progestin mechanism of action; effects on reproductive and non-reproductive behavior. LeHigh
University, Bethlehem, PA.
Frye, C.A. (1995). Hormonally mediated taste preference - caveats and qualifications. Eastern Psychological
Association, Boston, MA.
Frye, C.A. (1995). The functional role of neurosteroids: Animal and human studies. Symposium chair and
speaker, Winter Brain Conference, Steamboat Springs, CO.
Frye, C.A. (1994). Androgens actions to inhibit sexual receptivity are non-genomic. Workshop on Steroid
Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (1994). Non-genomic steroid effects relevant for reproduction. Symposium chair and speaker,
Conference on Reproductive Behavior, LeHigh Valley, PA.
Frye, C.A. (1993). Mk-801 and nimodipine: Neuroprotective effects may not extend to behavior. Cambridge
Neuroscience, Cambridge, MA.
ITEMS REFEREED
Organization
Alzheimer’s Association
American Academy of Neurology
American Heart Association
Burroughs-Welcome Trust (UK)
Epilepsy Foundation of America
Hunter College
INSERC (Canada)
Medical Research Council of Canada
National Institute of Mental Health
National Institute for Psychobiology in Israel
National Science Foundation
Neurological Foundation of New Zealand
Sigma Xi, National Research Honor Society
Swiss National Science Foundation
Veteran’s Affairs
The Welcome Trust (UK)
Archives of Medical Research
Behavioral Brain Research
Behavioral Neuroscience
Behavioral Pharmacology
Brain Research
Endocrinology
Frontiers in Experimental Endocrinology
Hormones and Behavior
Journal of Andrology
Journal of Biochemistry and Steroid Metabolism
Journal of Endocrine Investigations
Journal of Neuroendocrinology
Journal of Neuroscience
Journal of Neuroscience Methods
Journal of Peptide Research
Journal of Sexual Medicine
Journal of Steroids and Hormonal Science
32
Item reviewed
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
grants
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
Life Sciences
Neuroendocrinology
Neuropsychopharmacology
Neuroscience Letters
Pharmacology, Biochemistry and Behavior
Pharmacology Letters
Physiology & Behavior
Psychological Science
Psychoneuroendocrinology
Psychopharmacology
Steroids
Stress
Neurosteroids, A New Regulatory Function in the Nervous System
Trends in Endocrinology and Metabolism
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
manuscripts
Book
Book
COURSES TAUGHT
(U=undergraduate course, G=graduate course)
Introductory Psychology (U)
Psychology as a Natural Science (U)
Experimental Psychology (U)
Research Methods in Human Development (U)
Motivation and Emotion (U)
Brain, Mind and Behavior (G)
Physiological Psychology (U & G)
Behavioral Neuroscience (U & G)
Advanced Behavioral Neuroscience (G)
Neurobiology (G)
Seminar in Behavioral Neuroscience (U & G)
Behavioral Endocrinology (U & G)
Hormones and Behavior (U & G)
Psychopharmacology (U & G)
Individual Study (U)
Practicum in Neuroscience (U & G)
SOCIETIES, MEMBERSHIPS & AFFILIATIONS
American Association for the Advancement of Science
American Neuroendocrine Society
American Psychological Society
Developmental Psychobiology
Endocrine Society
International Behavioral Neuroscience Society
North East Under/graduate Research Organization for Neuroscience
(N.E.U.R.O.N., Co-Founder & Executive Steering Committee Member)
Sigma Xi, Research Honor Society
Society for Behavioral Neuroendocrinology
Society for Ingestive Behavior
Society for Menstrual Cycle Research
Society for Neuroscience
1990-1996
1998-present
1991-1997
1997-2001
1995-present
1995-2005
1996-present
1991-1998
1995-present
1992-2002
1992-1996
1989-present
GRADUATE STUDENT/POST DOC ADVISEES
Student
Institution Advised At
Current Affiliation/Position
Laura Bayon
Connecticut College
Saint Luke's Family Care Clinic
Pediatrics
Elizabeth Lacey
Connecticut College
Georgetown University
Rebecca Murphy
Connecticut College
Pfizer
Jill Vongher, PhD
Connecticut College
Neuropsychologist UChicago
Irene Chin
SUNY Albany
U Puget Sound
James Driscoll
SUNY Albany
Pfizer
Kassandra Edinger
SUNY Albany
Tutor in Albany-area
Fabiola Estrada
SUNY Albany
SUNY Albany
Lauren Farnbach
SUNY Albany
Arizona State University
Jeff Grizzaffi
SUNY Albany
Troy Regional High School
Vaishali Jahagirdar, PhD
SUNY Albany
SUNY Albany
Amy Kohtz
SUNY Albany
SUNY Albany
Danielle Llaneza
SUNY Albany
SUNY Albany
Neil Muscatiello
SUNY Albany
NY State Dept of Health
Danielle Osborne
SUNY Albany
SUNY Albany
Jason Paris
SUNY Albany
Torrey Pines
Sandra Petralia, PhD
SUNY Albany
Taconic
Steven Platek
SUNY Albany
Georgia Gwinnett College
Madeline Rhodes, PhD
SUNY Albany
McDaniel College
Kyungok Sim
SUNY Albany
U Texas
Kanako Sumida
SUNY Albany
SUNY Albany, Off. Resarch Compliance
Alicia Walf, PhD
SUNY Albany
Rensalaer Polytechnic Institute
UNDERGRADUATE STUDENTS SUPERVISED* indicates students that co-authored publications
Chris Acer
Christina Castro
Trisha Diamond
Jonathan Friedman
Jason Ackerman
Madison Chester
Johanna Diaz
Jennifer Gallagher
Arlene Adams
Annie Cheung
Eleni Dimitriadis
Dario Garcia
Dana Alvarez
Lesley Cole
Luigi DiRienzo
Sara Gardiner*
Allison Arneill
Peter Copeland*
Lauren Doherty
Amy Gazzara
Lyndsey Avalone
Candice Crain
James Driscoll
Rita German
Alicia Babson*
Caitlin Crowley
Jennifer Duncan*
Melissa Gnech
Laura Bayon*
Susan Crystal*
Jeffrey Duqette
Jeremy Gold
Sheena Ballard
Carlos Cuevas*
Caryn Duffy*
Taylor Goldberg
Alysha Binon
Patricia Currier
Kassandra Edinger*
Barbara Graham
Matt Blackman
Daniel Cusher
Dana Ericco
Jeff Grizzaffi
Theresa Blakesley
Daniel DaCosta
Kate Fagan-Solis
Gloria Guptill
Dana Braseth
Sangha Dalimbkar
Kristin Fields
Rebecca Habernig
Jennaye Brown
Abigail Davidson
Digna Figeuroa
Fareed Haddad
Damali Carrington
Errene Delnevo
Alyssa Fluty*
James Hanks
Brian Carroll
Allyson Delprino
Nicole Frederick
Emily Hey
34
Bushra Helmandi
Nicole Hercules
Tom Herman
Janet Heuring
Megan Hickey
Michael Horlacher
Pascale Houanche
Shannon Jeddi
Michelle Jolicoeur
Christina Joseph
Oreisha Jordan
Julia Keene
Ryan Keller
Kendall van Keuran*
Seehee Kim
Amy Kohtz*
Carolyn Koonce*
Kyana Kylek
Elizabeth Lacey*
Scott Lamm
Nicolas Lapis
Elizabeth Leadbetter*
Bomi Lee*
Bryan Licata
Juan Lin
Danielle Llaneza*
Mayulie Luciano
John Lusins
Niclas Luongo
Tara Mahar
Soobin Maeng
Jennifer Marrone*
Jacob Martinez
Jim McDonald
Stephanie McKnight
Frances Melendez
Elana Mendelson
Paul Mermelstein*
John Merriman
Ashley Morelli
Amy Morrison
Laura Murray
Eric Olson
Ryan O’Mara
Zoe Orecki*
Romae Palmer
David Park*
Aarat Patel
Anne Plaut
Kathy Prevost
Neena Pursnani*
Marie Rafalski
Tinisha Ransome
Trent Reed*
Eric Rist
Emily Roberge
John Roberts
Allicia Ryan*
Kristin Sanderson*
Nith Sanikone
Anthony Santarelli
Vanessa Sarfoh
Trudy Scalise*
Samantha Schmidt
Nicole Schmitt
Angela Seliga*
Aaron Sheppard
Jennifer Shorten
Zachary Simpsom
Andrew Slater
Kylie Small
Alex Smith
April Smith
Emer Smith
David Spangler
Laurie Spofford
Darcy Spitzer
Leanna Stager
Tara Stanko
Brittany Stebbins
Mathew St. Pierre
Ben Stein*
Robert Steger
Jodi Sturgis*
Kanako Sumida*
Masako Tanaka*
David Tedeschi
Sally Tetrault
Sheri Thayil
Hericka Torres
Khristina Ulmer
Mary Unger
Jana Vanderslice- Barr
Chris Voets
Taryn Walcott
Alicia Walf*
Chris Walsh
Joanna Wawrzycki*
Risa Weisberg*
Samuel Wilken
Jari Willing
Chris Wilming
Boris Yaguda
Stephanie Youmans
Sephehr Zandi
Eric Zho
COMMITTEES SERVED
Institution
Tufts University
Bates College
Boston Univ.
Level of Committee
Department
Department
Campus
Local
National
Department
Campus
Campus
Local
Departmental
Campus
Local
Regional
International
Connecticut
Department
Role
Years
Colloquium Committee
1989/1990
Animal Use & Care
1990/1991
Sigma Xi, Research Honor Society
1991/1992
Boston Area Neuroscience Gathering
1990-1992
Conference Committee for Soc. Ingestive Behavior 1991/1992
Search Committee for Social Psychologist
1992/1993
Sigma Xi, Research Honor Society
1992/1993
Howard Hughes Grant Committee
1992/1993
Boston Area Neuroscience Gathering
1992/1993
Colloquium Committee
1993/1994
Sigma Xi, Research Honor Society, Secretary
1993-1995
Boston Area Neuroscience Gathering
1993-1995
New England Consortium for Undergraduate
1993-1995
Science Education
Local Organizing Committee Society for Behavioral1994/1995
Neuroendocrinology
Laboratory and Animal Facility Coordinator 1995/1996
2
College
SUNY Albany
Campus
Department
Campus
Campus
Campus
Campus
Campus
Campus
Local
Local
Regional
Colloquium Committee Coordinator
Director of Neuroscience
Animal Care & Use Committee
Research Committee, Chair
Howard Hughes Grant Committee
Psi Chi, Psychology Honor Society
Study Abroad/Teach Abroad
Boston Area Neuroscience Gathering
Brain Awareness Week
North East Under/graduate Research Organization
for Neuroscience
National
Connecticut College’s Alumnae Outreach
Department
Search Committee for Behavioral Neuroscience
Faculty (co-chair 99/00)
Department
Search Committee for Social Psychology Faculty
Department
Honors Committee
Department
Colloquium Committee
Department
Social Committee
Search Committee for Radiation Safety Officer
Campus
Radiation Safety Committee
Campus
Research Facilities Implementation Comm
Campus
College Council
Campus
Animal Facility User Committee
Campus
Life Science Building Advisory Committee
Campus
Research Council
Campus
Researchers’ Liason Committee (co-chair)
Local
Brain Awareness Week
Regional
N.E.U.R.O.N., President
International
International Behavioral NeuroscienceSociety
Membership Committee
International
Program Committee- Steroids & Nervous System
Conference
International
Program Committee- Pharmacology Biochemistry
& Behavior Conference
45
1996/1997
1995-1997
1995-1997
1996-1997
1995/1996
1995/1996
1995-1997
1995-1998
1995-1998
1995/1998
1995/1996
1998-2000
2001-2001
1999-2009
2000-2007, 2009
2000-2007, 2009
1999, 2001
1999-present
2000-2001
1999-2001
2000-2001
2003-2007
2004-2006
2006-2009
1998-present
1998-present
2000-2002
2002-present
2003-present
REFERENCES can be provided by
Joseph F. DeBold, Ph.D.
Professor
Tufts University
Department Of Psychology
Psychology Building
490 Boston Avenue
Medford, MA 02155
(617) 627-5901
joe.debold@tufts.edu
Robin B. Kanarek, Ph.D.
Professor of Psychology
Tufts University-Department of Psychology
490 Boston Avenue
Medford, MA 02155
(617) 627-5902
robin.kanarek@tufts.edu
Cheryl McCormick, Ph.D.
Professor & Chair in Neuroscience
Brock University-Department of Psychology
MC B410
500 Glenridge Avenue
St. Catharines, Ontario, L2S 3A1 Canada
(905) 688-5550, ext. 3700
cmccormi@brocku.ca
Page B. Pennell, MD
Director of Research, Division of Epilepsy
Department of Neurology
Brigham and Women's Hospital
75 Francis Street
Boston, MA 02115
Phone: 617-732-7547
ppennell@partners.org
Jamie C. Rusconi, Ph.D.
Scientist, Molecular Analysis
Taconic, Inc.
5 University Place
Rensselaer, NY 12144
518-257-2030 ext. 12150
jamie.rusconi@taconic.com
Alicia A. Walf, Ph.D.
Clinical Assistant Professor
Cognitive Science Department
Rensselaer Polytechnic Institute
Carnegie Hall
110 Eighth Street
Troy, NY 12180
716-534-0591
aawalf@yahoo.com