CURRICULUM VITAE
Name:
Hong-May SIM
Citizenship: Singapore Citizen
Education:
2010
2005
Ph.D. (Pharmacy) (Pharmaceutical Chemistry),
National University of Singapore, Singapore
B.Sc. (Pharmacy) (Hons), National University of Singapore, Singapore
Brief Chronology of Employment:
2015 - present Instructor, Department of Pharmacy, National University of
Singapore, Singapore
2011 - 2015
Visiting Fellow, National Cancer Institute, National Institutes of Health,
Bethesda, Maryland, USA
2006 - 2010 Community Pharmacist (Locum), Unity NTUC Healthcare, Singapore
2006
Research Assistant, Department of Pharmacy, National University of
Singapore, Singapore
2001
Relief Teacher, Ministry of Education, Singapore
Board Certification and Professional Licensure:
Registered Pharmacist, Singapore Pharmacy Council, 2006 - present
Membership in Professional Societies:
1) American Chemical Society (2013 - present)
2) American Association for Cancer Research (2013 - present)
3) Pharmaceutical Society of Singapore (2005 - 2010)
Honors and Other Special Scientific Recognition:
1)
2)
3)
4)
NUS-Overseas Postdoctoral Fellowship, 2013- 2015
NIH Visiting Fellowship, 2011- 2015
Galderma local award, National University of Singapore, 2010
Global Scholarship Programme for Research Excellence Award, National University
of Singapore, 2010
5) International Relations Office Travel Award, National University of Singapore, 2009
Updated July 2015
CV of Hong-May Sim, Ph.D.
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6) NUS Alumni Student Exchange Programme Award, National University of
Singapore, 2004
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CV of Hong-May Sim, Ph.D.
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BIBLIOGRAPHY
Hong-May Sim, Ph.D.
Peer-Reviewed Articles:
1. Chufan EE, Sim HM, Ambudkar SV. Molecular basis of the polyspecificity of Pglycoprotein (ABCB1): recent biochemical and structural studies. Adv Cancer Res. 2015;
125:71-96. [IF = 5.321]
2. Wang DS, Patel A, Sim HM, Zhang YK, Wang YJ, Kathawala RJ, Zhang H, Talele TT,
Ambudkar SV, Xu RH, Chen ZS. ARRY-334543 reverses multidrug resistance by
antagonizing the activity of ATP-binding cassette subfamily G member 2. J Cell
Biochem. 2014; 115:1381-91. [IF = 3.263]
3. Sim HM, Bhatnagar J., Chufan E., Kapoor k., Ambudkar SV. Conserved Walker A
Cysteines 431 and 1074 in Human P-glycoprotein Are Accessible to Thiol-Specific
Agents in the Apo and ADP-Vanadate Trapped Conformations. Biochemistry. 2013;
52:7327-38. [IF = 3.015]
4. Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV. Multiple
transport-active binding sites are available for a single substrate on human P-glycoprotein
(ABCB1). PLoS One. 2013; 8:e82463. [IF = 3.234]
5. Wu CP, Hsiao SH, Sim HM, Luo SY, Tuo WC, Cheng HW, Li YQ, Huang YH,
Ambudkar SV. Human ABCB1 (P-glycoprotein) and ABCG2 Mediate Resistance to BI
2536, a Potent and Selective Inhibitor of Polo-like Kinase 1. Biochem Pharmacol.
2013;86:904-13. [IF = 5.009]
6. Wu CP, Sim HM, Huang YH, Hsiao SH, Cheng HW, Li YQ, Ambudkar SV, Hsu SC.
Overexpression of ATP-Binding Cassette Transporter ABCG2 as a Potential Mechanism
of Acquired Resistance to Vemurafenib in BRAF (V600E) Mutant Cancer Cells.
Biochem Pharmacol. 2013, 85:325-34. [IF = 5.009]
7. Liu KJ, He JH, Su XD, Sim HM, Xie JD, Chen XG, Wang F, Liang YJ, Singh S, Sodani
K, Talele TT, Ambudkar SV, Chen ZS, Wu HY, Fu LW. Saracatinib (AZD0530) is a
potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. Int J
Cancer. 2013, 132:224-35. [IF = 5.085]
8. Zhao XQ, Xie JD, Chen XG, Sim HM, Zhang X, Liang YJ, Singh S, Talele TT, Sun Y,
Ambudkar SV, Chen ZS, Fu LW. Neratinib Reverses ATP-Binding Cassette B1Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo. Mol.
Pharmacol. 2012, 82:47-58. [IF = 4.128]
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CV of Hong-May Sim, Ph.D.
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9. Ma X, Tan ST, Khoo CL, Sim HM, Chan LW, Chui WK. Synthesis and antimicrobial
activity of N¹-benzyl or N¹-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines. Bioorg.
Med. Chem. Lett. 2011, 21:5428-5431. [IF = 2.420]
10. Sim HM, Wu CP, Ambudkar SV, Go ML: In vitro and in vivo modulation of ABCG2 by
functionalized aurones and structurally related analogs. Biochem. Pharmacol. 2011, 82:
1562-1571. [IF = 5.009]
11. Sim HM, Loh KY, Yeo WK, Lee CY, Go ML: Aurones as Modulators of ABCG2 and
ABCB1: Synthesis and Structure-Activity Relationships. ChemMedChem. 2011, 6: 713724. [IF = 2.968]
12. Sim HM, Lee CY, Ee PLR, Go ML: Dimethoxyaurones: Potent inhibitors of ABCG2
(breast cancer resistance protein). Eur. J. Pharm. Sci. 2008, 35: 293-306. [IF = 3.350]
Book Chapters and Invited Reviews:
1. Kapoor K, Sim HM, Ambudkar SV: Multidrug Resistance in Cancer: A Tale of ABC
Drug Transporters. Edited by Bonavida B. New York, Springer, 2013, pp. 1-34.
2. Patel A, Wang DS, Sim HM, Ambudkar SV, Chen ZS: ABC Transporter Modulatory
Drugs from Marine Sources: A New Approach to Overcome Drug Resistance in Cancer.
Edited by Efferth T. New York, Springer, 2014, pp. 183-208.
Oral Presentations
1. Sim HM, Ee PLR, Go ML. 4,6-Dimethoxyaurones as dual modulators of P-glycoprotein
(P-gp) and breast cancer resistance protein (BCRP). European School of Medicinal
Chemistry, July 2008, Urbino, Italy.
2. Sim HM and Go ML. Structurally modified aurones as inhibitors of the ATP binding
cassette transport protein ABCG2 (breast cancer resistance protein). 10th Asia Pacific
Rim Universities Doctoral Students Conference, July 2009, Kyoto, Japan.
3. Sim HM and Go ML. Structurally modified aurones: Inhibitors of the ATP binding
cassette transport proteins Breast Cancer Resistance Protein (ABCG2) and Pglycoprotein (P-gp (ABCB1). 7th International Symposium for Chinese Medicinal
Chemists, Feb 2010, Kaoshiung, Taiwan.
4. Sim HM, Yu XZ, Chufan EE, Shukla S, Taraska W. J, Ambudkar SV. Mapping
conformational changes in human P-glycoprotein during its catalytic cycle with transition
metal ion FRET and disulfide crosslinking. Seminar at the Laboratory of Cell Biology,
National Institutes of Health, National Cancer Institute, May 2015, Bethesda, Maryland,
USA
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CV of Hong-May Sim, Ph.D.
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Poster presentations
1. Sim HM, Wu CP, Ambudkar SV, Go ML. In vitro and in vivo modulation of ABCG2 by
functionalized aurones and structurally related analogs. NIH Research Festival, October
2011, Bethesda, MD.
2. Sim HM, Bhatnager J, Chufan E, Ambudkar SV. Determination of conformational
changes in the ATP sites during the catalytic cycle of P-glycoprotein (ABCB1). 12th
Annual CCR Fellows and Young Investigators Colloquium, March 2012, Bethesda, MD.
3. Sim HM, Bhatnagar J, Gonzalez A, Chufan E and Ambudkar SV. Determination of
conformational changes in the ATP sites during the catalytic cycle of P-glycoprotein
(ABCB1). 9th Annual North American ABC Genetic Workshop, September 2012,
Frederick National Laboratory for Cancer Research, MD.
4. Wo SK, Sim HM, Go ML, Zuo Zhong. Investigation on the liver metabolic stabilities of
a series of 4,6-dimethoxyaurones and their structural analogs, AAPS annual meeting and
exposition, October 2012, Chicago, USA.
5. Sim HM, Bhatnagar J, Green SA, Gonzalez A, Kapoor K, Chufan EE and Ambudkar SV.
Probing accessibility and conformational changes in ATP-binding sites during the
catalytic cycle of human P-glycoprotein (ABCB1). American Association for Cancer
Research, April 2013, Washington D.C, USA.
6. Wu CP, Sim HM, Hsiao SH, Luo SY, Tuo WC, Cheng HW, Li YQ, Huang YH,
Ambudkar SV. Human ABCB1 (P-glycoprotein) and ABCG2 Mediate Resistance to BI
2536, a Potent and Selective Inhibitor of Polo-like Kinase 1. 10th Annual North
American ABC Genetic Workshop, September 2013, Frederick National Laboratory for
Cancer Research, MD.
7. Sim HM, Yu XZ, Chufan EE, Taraska W. J, Ambudkar SV. Mapping conformational
changes in P-glycoprotein (ABCB1) during its catalytic cycle. Membrane Protein Interest
Group and Structural Biology Interest Group Postdoc Symposium, April 2014, Bethesda,
MD.
8. Sim HM, Yu XZ, Chufan EE, Shukla S, Taraska W. J, Ambudkar SV. Mapping
conformational changes in human P-glycoprotein during its catalytic cycle with transition
metal ion FRET and disulfide crosslinking. Gordon Research Conference, May 2015,
Lucca, Italy.
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