CURRICULUM VITAE
Biographical Data
Ocober 1999
Name: David Joseph Valacer, M.D.
Date of Birth: April 18, 1953
525 E. 68th St., - Rm. J116
New York, NY 10021
N.Y. State License Number:
147997
Education
1971-1973
University of Massachusetts
Amherst, Massachusetts
Chemistry
1973-1975
College of the Holy Cross
Worcester, Massachusetts
1975, B.A.
1975-1979
University of Vermont
College of Medicine
Burlington, Vermont
1979, M.D.
Medicine
Chemistry
Magna Cum Laude
Postgraduate Training
1979-1980
Columbia-Presbyterian
Medical Center
New York, New York
Intern
Pediatrics
1980-1982
Columbia-Presbyterian
Medical Center
New York, New York
Resident
Pediatrics
1982-1984
University of California
San Francisco, California
Fellow
Allergy and
Clinical Immunology
Professional Employment and Hospital Appointments
1984-1985
Pediatric Allergy and Pulmonology
General Pediatric Medical Staff
Fallon Clinic
Worcester, Massachusetts
1985-1991
Director, Pediatric Asthma Center
Division of Pediatric Allergy/
Pulmonology
Schneider Children's Hospital
of Long Island Jewish Medical
Center, New Hyde Park, New York
1991-pres
Chief, Pediatric Allergy, Immunology
and Pulmonology
New York Hospital-Cornell Medical
Center, New York, New York
1991-pres
Director, Children's Allergy,
New York Hospital-Cornell Medical
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Immunology and Respiratory Center
Center, New York, New York
1991-pres
Director, Pediatric Pulmonary
Function Laboratory
New York Hospital-Cornell Medical
Center, New York, New York
1993-1996
Director, Pediatric Chest Clinic
Methodist Hospital
Brooklyn, New York
1996-pres
Chief, Division of General Pediatric
Medicine
New York Hospital-Cornell Medical
Center, New York, New York
1998
Pediatric Committee for Review
of Appointments and Promotions
New York Hospital-Cornell Medical
Center, New York, New York
Academic Appointments
1984-1985
Instructor, Voluntary
Faculty Associate
University of Massachusetts Medical
School, Worcester, Massachusetts
1985-1989
Assistant Professor of Pediatrics
SUNY Health Sciences Center
Stony Brook, New York
1989-1991
Assistant Professor of Pediatrics
Albert Einstein College of Medicine,
Yeshiva University, New York, New York
1991-1994
Assistant Professor of Pediatrics
Cornell University Medical College,
New York, New York
1991-pres
Assistant Professor of Pediatrics
Director, ACGME Accredited
Training Program in Allergy
and Clinical Immunology
Cornell University Medical College,
New York, New York
1994
Associate Professor of Pediatrics
Cornell University Medical College,
New York, New York
1997-pres
Director, ACGME Accredited
Training Program in
Pediatric Pulmonology
Cornell University Medical College,
New York, New York
Certifications
1980
1984
1985
1990
1994
Diplomate, National Board of Medical Examiners
Diplomate, American Board of Pediatrics
Diplomate, American Board of Allergy and Immunology
Diplomate, Diagnostic Laboratory Immunology
Diplomate, Pediatric Pulmonary Subspecialty Board
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Professional Society Membership
1983
1983
1985
1985
1986
1988
1990
1991
American Academy of Pediatrics, Fellow
American College of Allergy and Immunology
American Academy of Allergy, Asthma and Immunology, Fellow
New York Allergy and Immunology Society
New York Academy of Sciences
Asthma and Allergy Foundation of America
American Association for the Advancement of Science
American Thoracic Society
Awards & Honors
1970
1974
1975
1983
1996-99
1996
1997-99
1998
1999
Rensselaer Polytechnic Institute Mathematics and Science Award
American Chemical Society Award for Analytical Chemistry
Phi Beta Kappa
American Academy of Allergy and Immunology Geigy Fellow
"Best Doctors in New York", New York Magazine
Middle College High School - Career Education Faculty Outstanding Intern
Supervisor
National "Will to Win" Asthma Scholarship Judge
Bright Futures Consultants Panel
Merck Respiratory U.S. Pediatric Asthma Advisory Board
Grants& Contracts
1983
Asthma and Allergy Foundation of America Research Grant.
1988
Long Island Jewish Medical Center Faculty Research Award, Principal Investigator.
1988
Schering Corporation Research Support Grant.
1988-1991
National Institute of Health Randomized Double Blind Study of Intravenous
Immunoglobulin in Children with HIV Infection Contract, Co-Principal Investigator.
1989
Long Island Jewish Medical Center Faculty Research Award, Principal
Investigator.
1989-1991
Fan Fox and Leslie Samuels Foundation, Pediatric Asthma Center, Co-Investigator.
1990-1991
National Institute of Health, NICHD/NIAID Pediatric Aids Clinical Trials Group; CoPrincipal Investigator.
1992-1997
US Public Health Service Healthy Tomorrows Partnership for Children Grant,
Pediatric Comprehensive Asthma Management Program - Principal Investigator.
Page 4
1993-1996
B. Altman Foundation Grant for Pediatric Pulmonary Outreach Program Principal Investigator.
1994-1995
A Double-Blind Parallel Group Evaluation of the Efficacy and Quality of Life Outcomes
of Salmeterol Versus Placebo in Asthma Patients (Glaxo Inc.) - Participating Principal
Investigator.
1994-1998
A Study of Three Dose Levels of Budesonide (Pulmicort) Nebulizing Suspension and
Placebo in Asthmatic Children Aged Eights Years and Younger (Astra USA) Participating Principal Investigator.
1994-1996
A Phase II Trial: Venoglobulin-I (10%) in the Treatment of Severe, Steroid Dependent
Asthma, Atopic Dermatitis and Hyper-IgE Syndrome (Alpha Therapeutic Corporation) Participating Principal Investigator.
1996-1998
Calder Foundation Grant for Pediatric Asthma Outreach Program
Principal Investigat
1996 - 1997
A Phase II, Multicenter, Double-blind, Placebo-controlled Study to
Evaluate the Safety and Efficacy of anti-IgE Recombinant Humanized Monoclonal
Antibody (rhuMAb-E25) in Subjects with Moderate to Severe Allergic Asthma
(Genentech, Inc.) - Participating Principal Investigator.
1997
The Cultural Adaptation into Hispanic of the Rhinoconjunctivitis Quality of Life
Questionnaire (adult version) (Hoechst Marion Roussel)- Participating Principal
Investigator.
1997
"Performance Acceptability of the UnijectTM Pre-filled Injection System"
(Becton Dickinson and Co.)
Participating Principal Investigator
1997- 1998
A Randomized, Open Label, Cross-Over Study Comparing Present
ParentGuardian Preference for Montelukast sodium Tablets or Cromolyn Sodium
Aerosol (MDI) Treatment in their Children ages 6 to 11 with Chronic Asthma.
(Montelukast) Merck & Co., Inc.) - Participating Principal Investigator
1998-1999
A Double-Blind Placebo-Controlled Study to Evaluate the Effects of Treatment
of Seasonal Allergic Rhinitis (SAR) in Subjects With Co-Morbid Asthma and a
History of Seasonal Exacerbations of Asthma on Medical Resources Utilization
(For Asthma and SAR) (Schering Plough Corp.) - Participating Principal
Investigator
1998-pres
A One-Year, open-Label Study to Evaluate the Safety of HFA Flunisolide in
Children with Mild to Moderate Asthma (Forest Laboratories, Inc.) -
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Participating Principal Investigator
1999-pres
Double-Blind Study of the effects of one year of treatment with Mometasone
Foroate vs Placebo on growth of children with Asthma (Schering-Plough
Research Institute) - Participating Principal Investigator.
Other Professional Activities
1987-1991
Coordinator of Allergy/Immunology Fellowship Training in Pediatrics, Schneider
Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, New York
1987-1991
Coordinator of Pediatrics AIDS Clinic, Queens Hospital Center, New York, New York
1988-1991
Assistant Editor, "Children's Hospital Quarterly" Schneider Children's Hospital of Long
Island Jewish Medical Center, New Hyde Park, New York
1988-1991
Instructor, Interpreting Medical Research Course for Pediatric Fellows, Schneider
Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, New York
1988-1991
Member, Pediatric Ethics Committee, Schneider Children's Hospital of Long Island
Jewish Medical Center, New Hyde Park, New York
1991-pres.
Director of Pediatric Allergy and Clinical Immunology Fellowship Training Program,
New York Hospital-Cornell Medical Center, New York, New York
1991-pres.
Instructor, Medical Students Ethics Course, New York Hospital-Cornell Medical Center,
New York, New York
1992-1994
Member, New York Allergy and Immunology Society Executive Committee
1992-pres.
Pediatric Housestaff Education Advisory Committee, New York Hospital-Cornell
Medical Center, New York, New York
1995-1996
Cornell Community Service Program Advisory Board,New York Hospital-Cornell
Medical Center, New York, New York
Page 6
Bibliography
Original Communications in Reviewed Journals
1.
Goetzl EJ, Valacer DJ, Payan DG, Wong MYS: Abnormal responses to aspirin of leukocyte
oxygenation of arachidonic acid in adults with aspirin intolerance. J Allergy Clin Immunol, 77:693-98,
1986.
2.
Ilowite NT, Wedgwood JF, Valacer DJ, Ramakrishnan T, Bonagura VR: Detection of the major
rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with
polyarticular juvenile rheumatoid arthritis. J Rheum, 15:1789-92, 1988.
3.
Bonagura VR, Cunningham-Rundles S, Edwards BL, Ilowite NT, Wedgwood JF, Valacer, DJ:
Common variable hypogammaglobulinemia, recurrent pneumocystis pneumonia on intravenous
gammaglobulin therapy, and natural killer deficiency. J Clin Immunol and Immunopathol, 51:216-31,
1989.
4.
Edwards BL, Bonagura VR, Valacer DJ, Ilowite NT: Mucha-Habermann's disease associated
with reactivated EBV infection. J Rheumatol, 16:387-9, 1989.
5.
Ramakrishnan TP, Gloster E, Bonagura VR, Valacer DJ, Ilowite NT:
lymphadenitis in Lyme disease. Ped Inf Dis J, 8:180-1, 1989.
Eosinophilic
6.
Posner MA, Gloster ES, Bonagura VR, Valacer DJ, Ilowite NT: Burkitt's Lymphoma in a
Patient with Systemic Lupus Erythematosus. J Rheumatol, 17:380-2, 1989.
7.
Bonagura VR, Nisen P, Katz BZ, Gloster E, Mir R, Edwards BL, Valacer DJ, Lanzkowsky P:
Severe chronic EBV infection associated with specific EBV Immunodeficiency and an EBNA+ T-cell
lymphoma containing linear, EBV DNA. Clin Immunol and Immunopathol, 57:32-44, 1990.
8.
The NICHD Immunoglobulin Clincial Trial Study Group, Efficacy of intravenous
immunoglobulin for the prophylaxis of serious bacterial infections in symptomatic human
immunodeficiency virus-infected children, N Engl J Med, 325:74-80, 1991.
9.
Valacer DJ, O'Reilly ME, Ilowite NT, Bonagura VR, Identification of anti-idiotypic
autoantibodies in the sera of rye grass allergic and non-allergic individuals, J Allergy Clin Immunol,
88(3 pt 1):349-55, 1991.
10.
Bonagura VR, Ilowite NT, Hatam L, Valacer DJ, Wedgwood JF, The expression of the major
rheumatoid factor cross-reactive idiotype in systemic lupus erythematosus, Clin Immunol and
Immunopathol, 60(2):232-43, 1991.
Page 7
11.
Ramakrishnan TP, Ilowite NT, Wedgwood JF, Hatam L, Valacer DJ, Bonagura VR: The major
rheumatoid factor cross-reactive idiotype and IgA rheumatoid factor in juvenile rheumatoid arthritis, J
Rheumatol, 18:(7) 1068-72, 1991.
12.
Mofenson LM, Moye J, Bethel J, Hirschhorn R, Jordon C, Nugent R, and the Clinical Trial Study
Group for the National Institute of Child Health and Human Development. Prophylactic intravenous
immunoglobulin in HIV-infected children with CD4+ counts of 0.20 X 10 9/L or more. Effect on viral,
opportunistic, and bacterial infections. JAMA. 1992, 268(4):483-488.
13.
Mofenson LM, Bethel J, Moye J, Flyer P, Nugent R. The NICHD Immunoglobulin Clinical
Trial Study Group, for the National Institute of Child Health and Human Development. Effect of
intravenous immunoglobulin (IVIG) on CD4+ lymphocyte decline in HIV-infected children in a clinical
trial of IVIG infection prophylaxis. J Acquir Immune Defic Syndr 6(10): 1103-13, 1993.
Page 8
14.
Bienkowski RS, Brenner E, Cassidy RC, Frankel N, Sica AL, Solanto MV, Trachtman H, Walco
GA, Wedgwood J, Valacer DJ. A course in research methodology for pediatric fellows. Children's
Hospital Quarterly, 4(4), 1992.
15.
Strauss RE, Wertheim DL, Bonagura VR and Valacer DJ. Aminophylline therapy does not
improve outcome and increases adverse effects in children hospitalized with acute asthmatic
exacerbations. Pediatrics, 93:(2) 205-10, 1994.
16. Millar J.G.C., Valacer, DJ, Stavola J.J., Shanahan E., DiMaio M.F. Idiopathic bronchocentric
granulmatosis in an adolescent. Pediatric Pulmonology. 1997;23:62-65.
17. Cunningham-Rundles, S., Harbison, M., Guirguis, S., Valacer, DJ, And Chretien P.B. New
perspectives on use of thymic factors in immune deficiency. Annals NY Acad Sci 730:71-82 1994.
18. Kishiyama,J.,L., Valacer,D., Cunningham-Rundles, C., Sperber, K., Richards, G. W.,
Abramson, S., Glovsky, M., Stiehm, R., Stocks, J., Rosenberg, L., Shames, R. S., Corn, B.,
Shearer, W. T., Bacot, B., DiMaio, M., Tonetta, S., and Adelman,D.C., A multicenter,
randomized, double-blind, placebo-controlled trial of high-dose intravenous immunoglobulin
for oral corticosteroid-dependent asthma. Clin. Immunol. 91,126-133, 1999.
19. Anti-IgE (rhuMAb) Treatment Of The Symptoms Of Moderate-Severe Allergic Asthma. RB Fick,
MD; SJ Simon, MD; JQ Su, PhD; R Zeiger, MD, PhD and E25 Study Group; S. San Francisco, CA;
Austell, GA and San Diego, CA. Ann All, Asth & Imm submitted for publication 8/97.
Books, Chapters in Books, and Review Articles
1.
Valacer DJ, Bonagura VR: Allergenic extracts: Their characterization and standardization
towards more effective therapeutic preparations. Ped Rev and Comm, 2:147, 1987.
2.
Strauss R, Bonagura VR, Valacer DJ: Short course glucocorticosteroid use in acute asthmatic
exacerbation in children. Pediatric Rev and Comm, 5:83-93, 1990.
3.
Schuval SJ, Bonagura VR, Valacer DJ: Stinging Insect Allergy. Children's Hospital Quarterly,
2:1, 19-29, 1990.
Page 9
4.
Valacer DJ: New Treatments for Asthma: The Role of Leukotriene Modifier Agents.
JNMA, 91: 526 - 39, 1999
Abstracts
1.
Bonagura VR, Cunningham-Rundles S, Edwards B, Valacer DJ:
Common variable
hypogammaglobulinemia, recurrent pneumocystis carinii pneumonia on IVIG and natural killer
deficiency. J Allergy Clin Immunol, 81:288, 1988. Presented 1988, American Academy of Allergy and
Immunology meeting.
2.
Valacer DJ, O'Reilly ME, Bonagura VR: Anti-idiotypic antibodies (AB2) in Grass Allergic
Patients. J Allergy Clin Immunol, 83:A226, 1989. Presented 1989, American Academy of Allergy and
Immunology meeting.
3.
Edwards EL, Boxer M, Valacer DJ, Bonagura VR: Immediate hypersensitivity reaction to oral
estrogen. J Allergy Clin Immunol, 83:A269, 1989. Presented 1989, American Academy of Allergy and
Immunology meeting.
4.
Bonagura VR, Nisen P, Katz BZ, Edwards BL, Gloster E, Valacer DJ, Lanzkowsky P: Cytotoxic
T-cell deficiency, chronic EBV infection and T-cell lymphoma. J Allergy Clin Immunol, 83:A289,
1989. Presented 1989, American Academy of Allergy and Immunology meeting.
5.
Valacer DJ, Posner MA, Wipfler K, Bonagura VR: Predictive value of cefazolin skin tests in the
evaluation of non-life threatening reactions during cefaclor therapy in children. J Allergy Clin Immunol,
87:A559, 1991. Presented 1991, American Academy of Allergy and Immunology meeting.
6.
Minikes NI, Schuval S, Bonagura VR, Valacer DJ: Expansion of Leu2+7+ (CD8+CD57+)
lymphocyte subpopulation in symptomatic HIV+ children. J. Allergy Clin Immunol, 87:A267, 1991.
Presented 1991, American Academy of Allergy and Immunology meeting.
7.
Strauss RE, Bonagura VR, Valacer DJ, Effects of aminophylline on status asthmaticus in
children: J Allergy Clin Immunol, 87:A309, 1991. Presented 1991, American Academy of Allergy and
Immunology meeting.
8.
Bonagura VR, Cunningham-Rundles S, Schuval S, Applebaum E, Valacer DJ, Natural killer cell
deficiency in HIV+ infants with pneumocystis pneumonia and normal CD4+ T-cell number, J Allergy
Clin Immunol, 87:A317, 1991. Presented 1991, American Academy of Allergy and Immunology
meeting.
9.
Valacer DJ, Minikes N, Hatam L, Ramos M, Bonagura VR: Expansion and temporal variation
of the CD8+, CD57+ lymphocyte subpopulation (LS) in symptomatic HIV+ children (HIV+C). Ped
Research, 29:165A, 1991.
10.
Bonagura VR, Cunningham-Rundles S, Schuval S, Valacer DJ: Natural Killer deficiency,
normal CD4+ T-cells, in HIV+ infants with pneumocystis pneumonia, Ped Research, 29:153A, 1991.
Page 10
11.
Valacer DJ, Minikes N, Hatam L, Ramos M, Bonagura VR. Expansion and temporal variation of
the CD8+, CD57+ lymphocyte subpopulation in symptomatic HIV+ children. J Allergy Clin Immunol,
89:A501, 1992.
12.
Bonagura VR, Artandi SE, Agostino N, Valacer DJ, Natvig J, Randen I, Davidson A, Morrison
SL. Monoclonal synovial (SYN) and Waldenstrom (Wmar) IgM Rheumatoid factors (mRF) bind
differently to epitopes in genetically engineered chimeric IgG antibodies (cIgG). J Allergy Clin
Immunol, 89:A575, 1992.
13.
Guirguis S, Cunningham-Rundles S, Rappaport I, Valacer D. Thymosin Fraction 5 (TF5)
Therapy in a HIV negative girl with recurrent Respiratory Syncytial Virus and Cellular
Immunodeficiency. J Allergy Clin Immunol, 91:A10, 1993.
14.
Goldstein I, Valacer DJ, Bonagura VR. Immunotherapy (IT) associated with Circulating Immune
Complexes (CIC) and autoimmune symptoms. J Allergy Clin Immunol, 91:A349, 1993.
15. Stitzel AE, Johnson VL, Perlstein EM, Valacer DJ. Intravenous Immunoglobulin (IVIG) in the
treatment of membrane-proliferature glomerulonephritis. J Allergy Clin Immunol, 99:A746, 1997.
16. Kishiyama JL, Shames RS, Cunningham-Rundles C, Sperber K, Richmond GW, Abramson, S,
Valacer DJ, et al.. A multi-center, randomized placebo-controlled trial for high dose intravenous
gammaglobulin (IVIG) or oral corticosteroid-dependent asthma. J Allergy Clin Immunol, 99:A1093,
1997.
17. Lin DH, DiMaio MF, Muir W, Valacer DJ. Incidence of rodent dander sensitivity in an urban
population with allergic respiratory disease. J Allergy Clin Immunol, 99:A1592, 1997.
18.
Valacer DJ, Kishiyama JL, Corn B, et al. A multicenter, randomized, placebo-controlled trial of
high dose intravenous gammaglobulin for oral corticosteroid-dependent asthma. Am. J. Respiratory and
Crit Care Med, 155:A 659, 1997.
19. Juniper EF, MCSP, Meltzer EO, MD, Moreno J, MD, Valacer D, MD, Quinones H, PHD, Mear I,
MA, and Tanner A, MPH. Translation/Validation of the Rhinoconjunctivitis
Quality of Life Questionnaire (RQLQ) For Spanish Speaking Patients in N. America. J Allergy Clin
Immunol, 101: A1051, 1998.
20. Metzger WJ, Fick RB and E25 Asthma Study Group. Corticosteroid (CS) withdrawal in
a Study of Recombinant Humanized Monoclonal Antibody to IgE (rhu Mab E25). J Allergy
Clin Immunol, 101: A960, 1998.