Curriculum Vitae
February, 2010
PETER ANTHONY CROOKS,
MSc, PhD, FRPharmS, CSci, CChem, FRSC
George A. Digenis Professor in Drug Design and Discovery
University of Kentucky, College of Pharmacy
Department of Pharmaceutical Sciences
725 Rose Street
Lexington, KY 40536-0082
Tel. (859) 257-1718 Fax (859)257-7585
Professor *
Graduate Center for Toxicology
University of Kentucky
*Joint Appointment
I.
General Information
Home Address:
Telephone:
Email
409 W. Brannon Rd., Nicholasville, KY 40356
(859) 223-5401; FAX (859) 257-7585;
pcrooks@email.uky.edu
Licensure:
Year Certified:
Name of Speciality Board:
State/Country:
Registered Pharmacist
1969
Royal Pharmaceutical Society of Great Britain
Great Britain
II.
Education
1966
University of Manchester, United Kingdom
B.Sc. (Hons) First Class in Pharmacy
1967
University of Manchester, United Kingdom
M.Sc. in Pharmacy
l970
University of Manchester, United Kingdom
Ph.D. in Pharmacy
III.
Professional Experiences
1966-1967 Preregistration pharmacy training, University of Manchester, UK
1
IV.
Academic Appointments
1966-1967 Laboratory Demonstrator (full time),
University of Manchester, United Kingdom
1968-1970 Assistant Lecturer in Pharmacy (full time),
University of Manchester, United Kingdom
1969-1972 Assistant Warden and Tutor-in-residence,
Moberly Tower, Graduate Student Hall of Residence,
University of Manchester Campus, United Kingdom
1970-1980 Lecturer in Pharmacy (with tenure) (full time),
University of Manchester, United Kingdom
1976
Visiting Professor*, (Academic Links Scheme) (full time)
University of Naples, Italy
1976-1978 Research Associate*, (Secondment) (full time)
Yale Medical School,
Department of Pharmacology, USA
1980-1981 Senior Lecturer in Pharmacy (full time)
University of Manchester, United Kingdom
1981-1991 Associate Professor (full time)
College of Pharmacy University of Kentucky, USA
1983-pres. Associate Professor+ (joint appointment)
Graduate Center for Toxicology, University of Kentucky, USA
1988-1989 Visiting Scientistx (sabbatical leave) (full time)
Southern Research Institute, Birmingham, Alabama, USA
1991-pres. Professor (full time)
College of Pharmacy University of Kentucky, USA
1991-pres. Professor+ (joint appointment)
Graduate Center for Toxicology, University of Kentucky, USA
1996-1997 Visiting Scientistx (sabbatical leave) (full time)
RJR/Targacept, Winston-Salem, North Carolina, USA
2002-2004 Commonwealth University Professor in Pharmaceutical Sciences
College of Pharmacy, University of Kentucky, USA
2004-pres. George A. Digenis Professor in Drug Design and Discovery
Department of Pharmaceutical Sciences
College of Pharmacy, University of Kentucky, USA
2
Other Appointments
1986-pres. Member, Lucille P. Markey Cancer Center+
1989-pres. Member, Center on Aging+
1994-pres. Member, Center of Membrane Sciences+
*On leave of absence (secondment) from the University of Manchester
+Joint Appointment
xOn leave of absence (sabbatical) from the University of Kentucky
V.
Teaching Activity
Organic Chemistry for 1st Year Pharmacy Students, (4 credits, major responsibility), University
of Manchester, Department of Pharmacy.
Advanced Heterocyclic and Alicyclic chemistry for Final Year Honors Pharmacy Students, (3
credits, major responsibility), University of Manchester, Department of Pharmacy.
Absorption Spectroscopy of Organic Compounds, (2 credits, major responsibility), University of
Manchester, Department of Pharmacy.
Natural Products Chemistry/ Biogenesis of Natural Products of Medicinal Interest, (3 credits,
major responsibility), University of Manchester, Department of Pharmacy.
Basic Understanding of Spectroscopic Methods in Pharmaceutical Chemistry and their
Application to Drug Analysis, (3 credit didactic, 3 credit lab; secondary responsibility), University
of Manchester, Department of Pharmacy.
Pharmaceutical Chemistry-Drug Design: Physico-chemical Aspects of Drug Actions, DrugReceptor Interactions, Drug Metabolism and Chemotherapeutic Agents, (6 credit, 2 semester
course, major responsibility), University of Manchester, Department of Pharmacy.
Bio-organic Mechanisms in Drug Action, (Honors option, 3 credit course, major responsibility),
University of Manchester, Department of Pharmacy.
Principles of Medicinal Chemistry, (PHR 340) (4 credit hours, joint responsibility), University of
Kentucky College of Pharmacy.
Bio-organic Mechanisms (PHR 762, (3 credit, primary responsibility), University of Kentucky
College of Pharmacy.
Graduate Seminars in Medicinal Chemistry, (PHR 778) (1 credit per semester, 3 semester
course), University of Kentucky College of Pharmacy.
All-College Graduate Seminar in Pharmacy (PHR 776) (Coordinator-Major responsibility),
University of Kentucky College of Pharmacy.
3
Pharmaceutical Analysis (PHR 801), (4 credit course, secondary responsibility) University of
Kentucky College of Pharmacy.
Drug Metabolism, Theory and Practice, (PHR 664) (3 credit course, primary responsibility),
University of Kentucky College of Pharmacy.
Detoxification Mechanisms, (TOX 640), (3 credit course, secondary responsibility), University of
Kentucky, Graduate Center for Toxicology.
Modern Methods in Pharmaceutical Analysis (PHR 510), (5 credit course, secondary
responsibility), University of Kentucky College of Pharmacy.
Topics in Pharmaceutical Sciences - Use of High Field Nuclear Magnetic Resonance
Spectroscopy in Structural Analysis (PHR 760-003) (2 credit course, primary responsibility),
University of Kentucky College of Pharmacy.
Drug Form Design, (PHR 944), (3 credit course), University of Kentucky College of Pharmacy,
primary responsibility.
Topics in Pharmaceutical Sciences: Drug Targets and Actions, (PHR 760-008, 3 credit course),
University of Kentucky College of Pharmacy, secondary responsibility.
Special Topics in Pharmaceutical Sciences: Drug Design (FAGG 6213, 2 credit course, Fall
2004), School of Pharmacy, University of Puerto Rico San Juan, primary responsibility.
Topics in Pharmaceutical Sciences: Molecular Neurobiology of Abused Drugs, (PHR 760-008, 3
credit course, Fall semester), University of Kentucky College of Pharmacy, secondary
responsibility.
Biosynthesis of Natural Products (PHR 620, 3 credit course, Fall semester), University of
Kentucky College of Pharmacy, secondary responsibility.
VI.
Supervision of Graduate Students, Post-doctoral Fellows and
Visiting Scientists
Major Professor for the following students who have graduated with the degree of
Ph.D. or M.S.
Ph.D. Students
Howard E. Rosenberg (University of Cambridge, U.K.)
Richard Szyndler (University of Manchester, U.K.)
Trevor Deeks (University of Manchester, U.K.)
Peter Burn (University of Manchester, U.K.)
Eric Benghiat (University of London, U.K.)
Mohamad S. Shaker (University of Jordan)
Kenneth C. Cundy (University of Manchester, U.K.)
Abdul Al-Ghani Hoodi (University of Bagdhad, Iraq)
Samirah Hassan (University of Baghdad, Iraq)
Graduation Year
1975
1976
1979
1981
1982
1983
1984
1986
1987
4
Chukwemeka G. Nwosu (University of Pennsylvania, U.S.A.)
Riad Awad (University of Jordan)
William F. Pool (University of California, San Diego, U.S.A.)
C. Steven Godin (University of Massachusetts, U.S.A.)
Hana Dannan (University of Damascus, Syria)
Santosh C. Kottayil (University of Poona, India)
Supinan Na-Phuket (University of the Phillipines)
Jyothi Matharu (University of Bombay, India)
Omar Ghosheh (University of Jordan)
Michelle Howard-Sparks (University of Kentucky, U.S.A.)
Aimee Bence (Houghton College, U.S.A.)
Joshua R. Ring (Georgia Tech., U.S.A.)
Joshua T. Ayers (Dartmouth College, U.S.A.)
Aaron Haubner (University of Kentucky, U.S.A.)
M.S. Students
1987
1987
1987
1988
1988
1993
1997
1997
2000
2000
2001
2006
2006
2008
Graduation Year
Trevor Deeks (University of Manchester, UK)
Nabil N. Daoud (University of Baghdad, Iraq)
Jeffrey Leigh (University of Manchester, UK)
Amal N. A. Al-Taae (University of Baghdad, Iraq)
Shyamala Chandrasekaran (University of Poona, India)
Min Li (University of Beijing, People’s Republic of China)
David Worthen (St. Johns University, U.S.A.)
Jason Swango (Berea College, U.S.A.)
1976
1981
1982
1983
1993
1996
1997
1997
Research Supervision of the following Post-doctoral Fellows, Visiting Scientists,
and Scholars:
Postdoctoral Fellows
Dr. Francesco DeSimone (University of Naples, Italy)
Dr. Eliseo Ramundo (University of Naples, Italy)
Dr. Antonio Dini (University of Naples, Italy)
Dr. E. Huq (Bangladesh)
Dr. Michio Sato (Japan)
Dr. Abdulghani A. Houdi (University of Manchester, United Kingdom)
Dr. Terence Tita (University of Kentucky, U.S.A.)
Dr. Chen-Yie Chien (U.S.A.)
Dr. Anita Rathore (India)
Dr. Balwinder Bhatti (India)
Dr. Alain Ravard (France)
Dr. Naranjan Deo (Clemmson University, U.S.A.)
Dr. Grazyna Cynkowska (Poland)
Dr. Tadeusz Cynkowski (Poland)
Dr. Latch Trifonov (Bulgaria)
Dr. Chongxi Yu (USA)
Dr. Muhammad Qureshi (Pakistan)
Dr. Haeil Park (South Korea)
Dr. Srishailkumar B. Hadimani (India)
Graduation Year
1974,1975
1975
1975
1976 - 1977
1982 - 1983
1985 - 1986
1987
1986 - 1988
1989 - 1991
1990 - 1999
1991 - 1995
1992 - 1995
1993 - 2000
1993 - 2000
1994 - 1995
1995 - 1996
1996 - 1998
1996 - 1998
1996 - 1999
5
Dr. Raj Puri (India)
1997 - 1998
Dr. Wenkui Li (Hong Kong)
1998 - 1999
Dr. Xu- Rui (People’s Republic of China)
1998 - 2001
Dr. Xiaochen Wei (University of Kentucky, U.S.A.)
1999 - 2005
Dr. Vijayakumar Sonar (India)
2000 - 2008
Dr. Marhaba Hojahmat (Japan)
2000 - 2002
Dr. Neelakantan Sundar (India)
2000 - 2009
Dr. Guangrong Zheng (People's Republic of China)
2000 - present
Dr. Jianjun Gao (Japan)
2000 - 2001
Dr. Xiao Ming Yu (People's Republic of China)
2002 - 2003
Dr. Jianhong Chen (People's Republic of China)
2002 - 2006
Dr. Abeer M. Al Ghananeem (University of Kentucky, U.S.A.)
2002 - present
Dr. Mohamed Hamad (University of Sudan)
2002 - 2006
Dr. Timothy Benson (University of Manchester, U.K.)
2003
Dr. Fang Zheng (People’s Republic of China)
2003 - 2008
Dr. Zhenfa Zhang (People’s Republic of China)
2004 - present
Dr. Ahmad Malkawi (University of Jordan)
2004 - present
Dr. Shama Nasim (University of Karachi)
2004 - present
Dr. Venkatraj Muthusamy (Bharathidasan University, India)
2005 - 2006
Dr. Zaineb Fadhel (University of Bhagdad, Iraq)
2005 - present
Dr. Buchi N. Nalluri (Andhra University, India)
2005 - 2007
Dr. Ashish Vartak (University of Minnesota, U.S.A)
2006 - 2009
Dr. Thirupathi Reddy (National Institute of Technology, Warangal, India) 2006 - present
Dr. Vipin Purushothaman Nair (South Africa)
2006 - 2008
Dr. Syed Raziullah Hussaini (University of Oxford, UK)
2006 - 2007
Dr. Vijender R. Adelli (Indian Institute of Chemical Technology)
2007
Dr. Narismha R. Penthala (National Institute of Technology,
Warangal, India)
2007 - present
Dr. Purushothama Rao Ponugoti (Indian Institute of Chemical
Technology, Hyderabad, India)
2009 - present
Dr. Derong Ding (Shanghai Institute of Materia Medica; CAS)
2010 - present
Visiting Scientists
Dr. Jerzy W. Krechniak (Poland)
Dr. Lyaquatali A. Damani (University of Manchester,U.K.)
Dr. Zhao-Xia Fang (People's Republic of China)
Dr. Talal A. Aburjai (University of Jordan)
Dr. Bavntula Rajitha (National Institute of Technology, Warangal, India)
Dr. Yucel Kadioglu (Ataturk University, Turkey)
1984 - 1985
1985 - 1986
1988 - 1991
2004
2008
2009-present
Current Chairman or Member of the following Ph.D. dissertation committees
(University of Kentucky):
Mike Clark (Member)
Yibin Qiu (Member)
Yolanda Williams (Member)
Joshua Eldridge (Chairman)
Nikhil Madadi (Chairman)
Ujjwal Chakraborty (Co-Chairman)
David Horton (Member)
John Culver (Chairman)
Harpreet Kaur Dhooper (Co-Chairman)
Mikolaj Milewski (Member)
Cao Zheng (Member)
6
Past Chairman or Member of the following Ph.D. dissertation committees
(University of Kentucky):
K. Abdul-Nabi Ali, Pharmaceutical Sciences (Member)
Michael B. Maurin, Pharmaceutical Sciences (Member)
William Rencher, Pharmaceutical Sciences (Member)
George Garbolis, Pharmaceutical Sciences (Member)
Kenneth Cundy, Pharmaceutical Sciences (Chairman)
Prince Hinson, Pharmaceutical Sciences (Member)
Rong Fong Shen, Pharmaceutical Sciences (Member)
Lee Young Chau, Chemistry (Member)
Carl Niehaus, Pharmaceutical Sciences (Member)
David Wells, Pharmaceutical Sciences (Member)
Ralph Bouvette, Pharmaceutical Sciences (Member)
Fatima Tawfig, Pharmaceutical Sciences (Member)
Riad Awad, Pharmaceutical Sciences (Co-Chairman)
Samirah Hassan, Pharmaceutical Sciences (Chairman)
Chukwuemeka Nwosu, Toxicology (Chairman)
William Pool, Toxicology (Chairman)
Steven Godin, Pharmaceutical Sciences (Chairman)
Hana Dannan, Pharmaceutical Sciences (Co-Chairman)
Nurul Islam, Chemistry (Member)
Chang-Jin Wang, Pharmaceutical Sciences (Member)
Margaret Britto, Pharmaceutical Sciences (Member)
Janan Jona, Pharmaceutical Sciences (Member)
Santosh C. Kottayil, Chemistry (Co-Chairman)
Paul Yeary, Chemistry (Member)
Trupti Deshmukh, Pharmaceutical Sciences (Member)
Zhinan Xia, Pharmaceutical Sciences (Member)
Bin-Sun, Chemistry (Co-Chairman)
Danita M. Saxon, Nutritional Sciences (Member)
Randy Finch, Pharmaceutical Sciences (Member)
Shrong-Shi Lin, Pharmaceutical Sciences (Member)
Danny Kao, Pharmaceutical Sciences (Member)
Donna Isbell, Biochemistry (Member)
Yi Li, Chemistry, Chemistry (Member)
Min Li, Toxicology (Chairman)
Robert Trupp, Chemistry (Member)
Bassam Tashtoush, Pharmaceutical Sciences (Member)
Ashraf Traboulsi, Pharmaceutical Sciences (Member)
Prakash N. Nair, Toxicology (Member)
Mohammed S. Siddiqui, Chemistry (Member)
LiHong Teng, Toxicology (Member)
David Worthen, Pharmaceutical Sciences (Chairman)
Supinan Na Phuket, Pharmaceutical Sciences (Chairman)
Jyothi Matharu, Pharmaceutical Sciences (Chairman)
Chris Lockwood, Pharmaceutical Sciences (Member)
Mark Strohm, Pharmaceutical Sciences (Member)
Jason Swango, Pharmaceutical Sciences (Chairman)
Melissa Varner, Chemistry (Member)
Jaber Qasem, Pharmaceutical Sciences (Member)
Chinh Vu, Pharmaceutical Sciences (Member)
Omar Ghosheh, Pharmaceutical Sciences (Chairman)
7
Michelle Howard-Sparks, Pharmaceutical Sciences (Chairman)
Freddie Hughes, Jr., Chemistry (Member)
Marlon Jones, Chemistry (Chairman)
Xiaochen Wei, Agronomy (Member)
Alison Anderson, Pharmaceutical Sciences (Co-Chairman)
Aimee Bence, Pharmaceutical Sciences (Chairman)
Lincoln Wilkins, Pharmaceutical Sciences (Member)
Dong Zhang, Pharmaceutical Sciences (Co-Chair)
Joshua R. Ring, Pharmaceutical Sciences, (Chairman)
Lisa Middleton, Pharmaceutical Sciences (Member)
Chandra Patel, Pharmaceutical Sciencs (Co-Chair)
Joshua T. Ayers, Pharmaceutical Sciences (Chair)
Tao Liu, Pharmaceutical Sciences (Member)
Korie G. Sell, Pharmaceutical Sciences (Chair)
Joseph Medendorp, Pharmaceutical Sciences (Member)
Paul Kiptoo, Pharmaceutical Sciences (Member)
Stan Banks, Pharmaceutical Sciences (Member)
Aaron Haubner, Pharmaceutical Sciences (Chair)
Yik Ho, Pharmaceutical Sciences (Member)
VII.
Administrative Activity and University Service
At the University of Manchester
Staff-Student Committee, Department of Pharmacy
Member of the Board of the Faculty of Science
Secretary, Safety Committee, Department of Pharmacy
Member of Convocation, University of Manchester
Co-ordinator for Research Seminars
Senate Watchdog Committee (member)
Member of Postgraduate Committee, Faculty of Science
Postgraduate Admissions Officer, Department of Pharmacy
1968 - 1970
1970 - 1981
1978 - 1981
1978 - present
1978 - 1981
1979 - 1980
1980 - 1981
1980 - 1981
At the University of Kentucky
College
Student Affairs Committee (Member)
Graduate Program Committee (Member)
Curriculum Committee (Member)
Honors and Recognition Committee (Member)
Library Committee (Chairman)
Research and Seminar Committee (Member 1983-1984,
Chairman 1984-1986; Member 1986-1988)
Pharmacy Residency Seminar Committee (Member)
Nominations Committee (Member)
Buildings, Space, Services and Safety Committee
(Member, 1985-1986; Chairman, 1986-1987)
Administrative Council Committee (Member)
Building and Safety Committee (Chairman)
Nuclear Magnetic Resonance Committee (Chairman)
Graduate Program Coordinator, Division of Medicinal
1981 - 1982
1981 - 1986
1982 - 1985
1982 - 1984
1982 - 1985
1983 - 1988
1984 - 1985
1985 - 1986
1985 - 1987
1985 - 1988
1987 - 1988
1987 - 1999
8
Chemistry and Pharmaceutics
Nominations Committee (Chairman)
Graduate Program Committee (Member)
Building and Lab Safety (Member)
History of Drugs and Pharmacy (Member)
Admissions Committee (Member)
Continuing Education (Member)
Honor Code Committee (Member)
College of Pharmacy Safety Committee (Chairman)
Executive Committee, Division of Pharmaceutical Sciences,
College of Pharmacy (Member)
Faculty Search Committee (Pharmaceutics Position)(Member)
Faculty Search Committee (Drug Discovery and Design Positions)
(Chairman)
Nominations Committee (Member)
College of Pharmacy Safety Committee (Member)
DGRC Committee
DDD-AGS Coordinator
Faculty Search Committee (Drug Discovery and Design Positions)
(Member)
DGRC Committee (Member)
Faculty Search Committee (Drug Discovery and Design Positions)
(Member)
Safety and Security Committee (Member)
Appointment, Promotion, and Tenure Committee (Member)
Conflict of Interest Management Committee (Member)
Promotion and Tenure Committee (Chairman)
1989 - 1992
1989 - 1990
1989 - 1996
1989 - 1996
1990 - 1991,
and 1992 - 1993
1991 - 1996
1991 - 1992
1992 - pres.
1997 - 2003.
2000 - 2002
2000 - 2001
2001 - 2002
2003 - 2004
2004 - 2005
2004 - 2005.
2004 - 2005.
2005 - 2006
2005 - 2006
2006 - 2007
2007 - 2010
2007 - 2010
2007 - 2010
2010 - on
Medical Center
Medical Center Safety Committee (Member)
Nuclear Magnetic Resonance Imaging
Users Committee (Member)
International Affairs Committee (Member)
College of Medicine Unit Review Team
1987 - 1989
1987 - pres.
1995 - 1996
2002 – 2003
University
Graduate School (Member)
Faculty Forum (College of Pharmacy representative)
International Students Committee (Member)
Council for International Programs (Member)
Executive Committee, Graduate Center
for Toxicology (Chairman)
Life Sciences Mass Spectroscopy
Oversight Committee (Member)
Nuclear Magnetic Resonance
Users Committee (Member)
International Affairs Committee (Member)
1982 - pres.
1984 - 1986
1986 - 1990
1986 - 1990
1988 - 1990
1990 - 2000
1989 - pres.
1995 -1996
9
Environmental Health and Safety Committee (Member)
Graduate Council (Member)
Chemical Safety Committee
Natural Product Alliance Committee
KTRDC Oversight Committee
1997 - 2002
1999 - 2002
2002 - 2004
2004 - pres.
2006 - pres.
Special Assignments
Self-Study Committee for ACPE Accreditation (Member)
College of Pharmacy Counselor for Foreign Students
Reviewer for University of Kentucky Scholarship Applications
Reviewer for Research Proposals submitted to the
Clinical Research Center, University of Kentucky
Faculty Retreat Committee, May, 1988
(member and group moderator)
Self-Study Committee for ACPE Accreditation,
Chairman of Committee dealing with Financial
Organization of the College
Chairman, College of Pharmacy,
Division of Medicinal Chemistry and Pharmaceutics,
Faculty Search Committee
Member, Task Force on Professional Programs,
College of Pharmacy
Chairman, Subcommittee on the Centralization of
Mass Spectroscopy
1983 - 1984
1986 - 1988
1987 - 1988
1988 - pres.
1988
1989 - 1990
1990 - 1991
and 1994
1991 - 1992
1991 - 1999
VIII. Awards and Honors
County Bursary Major Scholarship for entry into University of Manchester Pharmacy Program
(1962 - 1966)
Geigy Prize for Excellence in the B.Sc. (HONS) Pharmacy Course, University of Manchester, UK
(1966)
United Kingdom Science Research Council Scholarship for Post- graduate Studies in the
Pharmaceutical Sciences, University of Manchester, United Kingdom (1966 - 1968).
Wellcome Foundation Award (1976).
Designated a Chartered Chemist by the Royal Society of Chemistry (1992)
Nominated and elected by peer-review as a Fellow of the Royal Society of Chemistry, May
(1992).
Nominated and elected by peer-review as a Fellow of the Royal Pharmaceutical Society of Great
Britain (1992).
10
Nominated and elected by peer-review as a Fellow of the American Association of
Pharmaceutical Scientists (2002).
American Association of Pharmaceutical Scientists Outstanding Manuscript Award in Analysis
and Pharmaceutical Quality (1999).
Faculty Achievement Award, College of Pharmacy, University of Kentucky (2000).
Commonwealth University Professorship in Pharmaceutical Sciences, University of Kentucky
Medical Center (2002).
Wethington Award for Meritorious Performance in Research (2002, 2003).
Inducted into the Honorable Order of Kentucky Colonels (2003).
Rho Chi Alumni Honor Roll Award (Alpha Xi Chapter) for Intellectual Leadership and the Pursuit
of Excellence in Pharmacy (2004).
George A. Digenis Professor in Drug Design and Discovery, Department of Pharmaceutical
Sciences, College of Pharmacy, University of Kentucky, USA (2004).
Designated a “Chartered Scientist”, Royal Society of Chemistry, UK (2004).
Most Outstanding Teacher Award, Pharm. D. Class of 2007, College of Pharmacy, University of
Kentucky (2005).
Invited Keynote Address, A. Nelson Voldeng Memorial Lecture, Thirty Fourth Annual MALTO
Conference, University of Louisiana at Monroe, Monroe, LA, (2007).
Robert Blouin Graduate Program Teaching Award, College of Pharmacy, University of Kentucky
(2007).
Nominated and Elected by the American Association of Pharmaceutical Scientists membership
to the Executive Committee as Member-at-Large.
Invited Keynote Address, National Symposium on Recent Trends in Organic and Medicinal
Chemistry, National Institute of Technology, Warangal, India.
Member of the following Honor Societies:
Sigma Xi (Yale Chapter) Scientific Research Society
Rho Chi (Kentucky Chapter) Pharmaceutical Honor Society
Citations: National and International Biographical Directories
"American Men and Women in Science", 1989 Edition - pres.
11
"International Directory of Distinguished Leadership", Fourth Edition, 1991
"2,000 Notable American Men", First Illustrated Edition, 1992.
"The International Who's Who of Intellectuals", Tenth Commemorative Edition, 1992.
"International Register of Profiles", Eleventh Edition, 1992.
"Who's Who in the South and Southwest", 23rd Edition, Marquis Who's Who publications.
"Who's Who in Science and Engineering", 2nd Edition, Marquis Who's Who Publications.
"Men of Achievement", Fifteenth Edition, 1992.
"Dictionary of International Biography - The Biographical Record of Contemporary
Achievement", Edition XXIII, 1994.
“Who’s Who in Medicine and Healthcare”, 1st Edition, Marquis Who’s Who publications.
“Who’s Who of American Inventors”, 1998-1999 Edition.
“International Who’s Who of Professionals”, 1998 Edition.
“Strathmore’s WHO’s WHO”, 2002-2003 Edition, Strathmore Directories Ltd.
“Empire Who’s Who, 2003.
“United Who’s Who, 2003.
“AcademicKeys Who's Who in Pharmaceutical Sciences Education (WWPSE), 2004.”
“Marquis Who’s Who in America”, 64th Edition, Marquis Who’s Who Publications, Sixty Fourth
Edition, 2010.
IX.
Memberships and Fellowships in Professional Organizations
Fellow, Royal Pharmaceutical Society of Great Britain
Fellow, Royal Society of Chemistry
Fellow and Charter Member, American Association of Pharmaceutical Scientists
Member of the American Chemical Society
Member of the American Association for the Advancement of Science,
Member of the International Society for the Study of Xenobiotics
Member of the American Association of Colleges of Pharmacy
X.
Scientific Professional and Editorial Activities
Consultancies
Targacept
Marion Merrell Dow, Incorporated
12
Dynagen, Incorporated
R. J. Reynolds Tobacco Company
Viro-Kote, Incorporated
Endo Pharmaceuticals, Incorporated
Canadian Government, Patented Medicine Prices Review Board
Emlin Bioscience
Yaupon Therapeutics, Inc.
US World Medicines
Council of Healthcare Advisors
Novartis Pharmaceuticals
InSys, Inc.
Adams Respiratory Therapeutics
Professional Activities
President of the University of Manchester Pharmaceutical Society - 1975.
Elected Member of the Conference Science Committee, Pharmaceutical Society of Great Britain
- 1980-1982.
Symposium Organizer and Coordinator,
Pharmaceutical Conference, Brighton - 1981.
Medicinal
Chemistry
Symposium,
British
Moderator and Podium Session Chairman, Medicinal Chemistry Section, 39th National Meeting
and Exposition of the Academy of Pharmaceutical Sciences, American Pharmaceutical
Association, Minneapolis, Minnesota, 1985.
Invited participant, Workshop on the Effects of Tobacco Smoke Components on Cellular and
Biochemical Processes in the Lung, National Institutes of Health, National Heart, Lung and
Blood Institute, Bethesda, MD, 1986.
Invited Plenary Lecturer - 40th National Meeting of the Association of Official Racing Chemists,
Lexington, KY, 1986.
Member, National Institutes of Health Study Section - Drug Development and Drug Delivery
(SBIR Study Section) 1992 - 1998.
Committee Member, Office of Extramural Program Review, Contracts Review Branch, National
Institute on Drug Abuse, NIH, March, 1993 - present.
Reviewer for Merit Review Applications, Veterans Administration, Alcoholism and Drug
Dependence Review Board, Augusta, Georgia, August, 1993.
External Examiner for the Ph.D. degree, Organic Chemistry, Banaras Hindu University,
Varanasi, India, 1996-present
.
Chairman, Medicinal and Natural Products Chemistry Committee, American Association of
Pharmaceutical Scientists South-East Regional Planning Committee, 1998-1999.
13
Moderator and Symposium Organizer, Medicinal Chemistry and Natural Products/Biotechnology
Symposium: "Functional Genomics in Drug Discovery." 1999 Southeast Regional Meeting of the
American Association of Pharmaceutical Scientists, June, 1999, Durham, NC.
Expert Witness for the Patented Medicine Prices Review Board, Government of Canada,
Ottawa, Canada, June, 2000.
External Examiner (Dossier Evaluation) for Promotion of a Faculty member to Associate
Professor, Applied Sciences University, Amman, Jordan, September, 2000.
External Examiner for the Ph.D. degree, Organic Chemistry, Indian Institute of Technology,
Bombay, India, 2000-present.
Nominated and Elected by the AAPS Membership as Vice-Chair Elect, Drug Design and
Discovery Section, American Association of Pharmaceutical Scientists, November, 2001.
Reviewer, National Institute on Drug Abuse - Cutting-Edge Basic Research Awards (NIDACEBRA), 2002.
Vice-Chair, Drug Design and Discovery Section, American Association of Pharmaceutical
Scientists, 2002.
Member, American Association of Pharmaceutical Scientists 2003 Annual Meeting Program
Committee (AMPC), 2003.
Member, American Association of Pharmaceutical Scientists Fellows Selection Committee,
2004-on.
Member, American Association of Pharmaceutical Scientists 2004 Annual Meeting Program
Committee (AMPC), 2004.
Member, American Association of Pharmaceutical Scientists Program Coordination Committee
(PPC), 2003-2005.
Member, American Association of Pharmaceutical Scientists Strategic Visioning
(SVC), 2003-2005.
Committee
Member, American Association of Pharmaceutical Scientists Membership Strategic Oversight
Committee (MSOC), 2004-2006.
Member, American Association of Pharmaceutical Scientists National Biotechnology Conference
2005 Planning Committee, 2004-2005.
Chair Elect, Drug Design and Discovery Section, American Association of Pharmaceutical
Scientists, November, 2003
Chair, Drug Design and Discovery Section, American Association of Pharmaceutical Scientists,
May, 2004-November 2005.
14
Member, National Institutes of Health Study Section, Special Emphasis Panel – National
Cooperative Drug Discovery groups for the Treatment of Mood Disorders or Nicotine Addiction
(NIMH/NIDA ZMH1 BRB-S (09)), 2004.
Moderator and Symposium Co-Organizer, “Naturceuticals (Natural Products), Nutraceuticals,
Herbal Botanicals, and Psychoactives: Drug discovery and Drug-Drug Interactions”, NIDA-AAPS
Symposium, November 5-7, 2004, Baltimore, MD.
Moderator and Symposium Organizer, “Neuronal Nicotinic Receptors and Ligands: New Targets
for Medications Development” AAPS Symposium, November 8th, 2004, Baltimore, MD.
Moderator and Symposium Co-Organizer, “Predictive Intestinal Drug Absorption” AAPS
Symposium, November 10th, 2004, Baltimore, MD.
Member, American Association of Pharmaceutical Scientists, Nominations Committee, 2005-6.
Member, Canadian Institutes of Health, Drug Development Initiative: Research Resource Grants
Study Section, CIHR Research Translation Programs – Commercialization Program, 2005-2006.
Member, American Association of Pharmaceutical Scientists, 2006 Fellows Committee.
Member, American Association of Pharmaceutical Scientists, Awards Committee, 2006-2007.
Member, American Association of Pharmaceutical Scientists, Content Advisory Committee,
2006-2007.
Moderator and Symposium Organizer, “Bacterial Biofilm as a New target in the Discovery of New
Antibiotic Drugs” AAPS Symposium, October 31st, 2006, San Antonio, TX.
Moderator and Symposium Organizer, “AAPS Graduate Student Symposium in Drug Design and
Discovery” AAPS Symposium, October 31st, 2006, San Antonio, TX.
Moderator and Round Table Organizer, “Solid State Chemical Reactions of Significance in the
Formulation and Stability of Solid Dosage Forms” AAPS Round Table, October 31st, 2006, San
Antonio, TX.
Member, American Association of Pharmaceutical Scientists, 2007 Fellows Committee.
Moderator and Sunrise Session Organizer, “Targeted Prodrug Design” AAPS Sunrise Session,
November 2nd, 2006, San Antonio, TX.
Nominated and Elected by the AAPS Membership as Member-at-Large, AAPS Executive
Committee, 2007.
Member, National Institutes of Health Study Section, Special Emphasis Panel, “Drug Design for
the Neurological Sciences” [ZRG1 MDCN-G(91) Review Committee], 2007.
Member, American Association of Pharmaceutical Scientists, Drug Discovery and Delivery
Interface (D3I) Planning Committee, 2008.
Member, American Association of Pharmaceutical Scientists, Program Content Committee
(PCC), 2008.
15
Member, Quebec Intergrative Research Group (IRG), Research Hospital Fund (RHF)-LargeScale Institutional Endeavours (LSIE) Review Board, Canada Foundation for Innovation,
Montreal, Canada, February, 2008.
Chairman, Graduate Program Review Committee, College of Pharmacy, Department of
Medicinal Chemistry, University of Gainesville, Florida, March, 2008.
External Examiner for the Ph.D. degree, Organic Chemistry, National Institute of Technology,
Department of Chemistry, Warangal, India, 2008-present.
Member, National Advisory Committee, National Symposium on Recent Trends in Organic
Medicinal Chemistry, Department of Chemistry, National Institute of Technology, Warangal,
India, January, 2009.
Member, National Institute on Drug Abuse Study Section, NIH – GMP Synthesis of Bulk Drug
Substances (NIDA RFP N01DA-9-8881) [ZDA1 MXL-F (41) Review Committee], May, 2009.
Reviewer for Research Grant Applications, Kuwait University, Kuwait, August, 2009.
External Examiner for the Ph.D. degree, Organic Chemistry, Bharathidasan University,
Tamilnadu, India, 2009-present.
Media Events
University of Kentucky Press Release; "UK Researcher Develops Nicotinic Drugs with R.J.
Reynolds", July 27th, 1999, http://www.mc.uky.edu/mcpr/1999/july/nicotine.htm
Science Daily Press Release; "University of Kentucky Researcher Develops Nicotinic Drugs with
R.J. Reynolds", July 28th, 1999, http://www.sciencedaily.com
Interviewee, WKYT (CBS Lexington) Evening News, August 2nd, 1999; "Development of New
Drugs from Nicotine".
Interviewee, WKYT (CBS Lexington) Evening News, April 26th, 2000, "Development of New
Analgesic Drugs from Morphine".
University of Kentucky Press Release; "UK Researcher Develops Morphine Derivative", June
14th, 2000. http://www.mc.uky.edu/mcpr/news/2000/June/morphine.htm
AAPS Announces 2002 Fellows: Ten Honored for Professional Excellence in Pharmaceutical
Sciences, October 17th, 2002.
http://www.aapspharmaceutica.com/about/press/newsreleases/2002/101702.asp
Lexington Herald Leader, lead article: "Plant Possible Addiction Treatment", Oct. 30th, 2000,
page C5.
http://www.kentuckyconnect.com/health/stories/features/1030lobeline.htm
Lexington Herald Leader, article: “It’s All About the e’s”, Section C, January 27th, 2003.
16
National Institute on Drug Abuse: “Director’s Report to the National Advisory Council on Drug
Abuse”, February, 2003.
http://www.drugabuse.gov/Dirreports/Dirrep203/DirectorReport1.html
Lexington Herald Leader, lead article: “Cures and Currency: Success Story Inspires Hope for
UK-Business Partnerships”, March 9th, 2003, page A13.
http://www.kentucky.com/mld/heraldleader/5351696.htm
Tobacco Tech: Looking to the Future of Tobacco. “New Pharmaceutical Company to use Natural
Compounds from Plants.” Kentucky Tobacco Research and Development Center, University of
Kentucky, Issue 7, May, 2003.
University of Kentucky: Odyssey Online Exclusive. “Faculty Entrepreneurs Linda Dwoskin and
Peter Crooks: Research Findings to Crow About”. October 14th, 2003.
http://www.rgs.uky.edu/ca/odyssey/exclusive/index.html
Louisville Courier Journal: “Kentucky Puts Hopes in Natural-Products Sector”. November 9th,
2003. http://www.courier-journal.com/business/news2003/11/09/biz- front-natural09-6013.html
University of Kentucky Press Release; "Nicotine is Focus of Record Grant”. November 13th,
2003, http://www.uky.edu/PR/News/03-11_nicotine_grant.htm
WKYT (CBS Lexington) Mid-day and Evening News, November 13th, 2003; "UK Receives
Record Grant to Study New Treatments for Nicotine Addiction”.
WLEX (NBC Lexington) Mid-day and Evening News, November 13th, 2003; “UK Professors get
$6 million Grant to Develop New Drugs for Nicotine Addiction”.
WLKY (NBC Louisville) Mid-day and Evening News, November 13th, 2003; “UK Researchers Get
Record Grant to Study Nicotine Addiction”.
Lexington Herald Leader, front page story: "UK Gets $6 Million to Help Kick Nicotine: Grant
Award is Boost for College ", November 13th, 2003.
http://www.kentucky.com/mld/kentucky/news/7259103.htm
The Louisville Courier Journal, front page story: “UK Effort on Quitting Smoking Wins Grant:
Researchers’ Drug Aims to Stop Craving Without Nicotine”, November 13th, 2003.
http://www.courier-journal.com/localnews/2003/11/14ky/met-front-grant1114-5650.html
Kentucky Kernel: “Researchers get Record Grant: $6 Million Grant Helps College of Pharmacy
Study Nicotine, Tobacco”, November 13th, 2003. http://www.kykernel.com/
UK News: “Pharmacy gets Record Grant”, November 24th, 2003.
http://www.uky.edu/PR/UK_News/welcome.html
UK News: UKResearch-Spotlight, November 29th, 2004.
http://www.uky.edu/PR/UK/Nov_29_2004/UKResearch.html
17
Crooks named George A. Digenis Professor in Drug Design and Discovery, January 28th, 2005.
http://www2.mc.uky.edu/pharmacy/news_archive.asp?id=15
“Will Combinatorial Chemistry Keep its Promise?” Biotechnology Healthcare, June, 2005.
http://www.biotechnologyhealthcare.com/journal/fulltext/2/3/BH0203026.pdf
“Making Drugs on Slim Budget.” Philadelphia Inquirer, December 5th, 2005,
http://www.philly.com/mld/inquirer/business/13328745.htm
“Kentucky Reaping Benefits from Bucks for Brains”, December, 23rd, 2005,
http://www.research.uky.edu/ca/rctf/05_rctf_handout.pdf
“Ion Channel Research Lab Registry: Ion Channel Media Group”, March 39th, 2006,
http://www.ionchannels.org/showauthor.php?surname=Crooks&initials=PA
“Drugs to Fight Addictions”, Cover Story, Chemical and Engineering News, September 25th,
2006, http://pubs.acs.org/cen/coverstory/84/8439additions.html ; Chemical and Engineering
News, 2006, 84 (39), 29-44.
“Nomination for Vice-Chair of the Division of Medicinal Chemistry, American Chemical Society by
the ACS Nominations Committee”, November, 2006,
http://wiz2.pharm.wayne.edu/crooks.html
“Headache Herb may Boost Cancer Survival”, Indiana University Research and Creative Activity,
Vol. XXIX (Number 1), Fall, 2006,
http://www.indiana.edu/~rcapub/v29n1/herb.shtml
“UK Colleges of Pharmacy and Agriculture Partner to Advance Potential New Plant-based
Medicine”, September 13th, 2007, http://www.mc.uky.edu/pharmacy/news_archive.asp?id=454
“ABC News: Flower Power: A Cure for Cancer? Research Shows that Common Garden Plant
Might Kill Leukemia Cells”, October 9th, 2007,
http://abcnews.go.com/Technology/CancerPreventionAndTreatment/story?id=3707277&page=1
“Leuchemix Announces Publication of Data on its Lead Cancer Drug Candidate”, October 15th,
2007, http://biz.yahoo.com/pz/071015/128589.html
“Yaupon Therapeutics Closes $14.5 Million Financing”, November 26th, 2007,
http://www.econdev.uky.edu/news/yaupon_funding.html
“Alternative with Healing Benefits”, Tobacco Journal International, 2007, 6, 84-85,
www.tobaccojournal.com
“Morphine-Cannabis Combo may Boost Painkilling Response”, Thindian News, August 12th,
2008, http:/www.thaindian.com/newsportal/health/morphine-cannabis-combo-may-boost-painkilling-response_10083056.html
“Invention: Morphine-Cannabis Super-Painkiller”, August 12th, 2008,
http://www.newscientist.com/article/dn14344-invention-morphinecannabissuperpainkiller.html?feedId=tech_rss20
18
“Crooks Presents Golden Jubilee Keynote Address in India”, April 2nd, 2009,
http://pharmacy.mc.uky.edu/display.php?id=627
“Yaupon Takes Skin-cancer Drug into Patent Trials”, New Hampshire Union Leader, July 6th,
2009, http://www.unionleader.com
“Yaupon Therapeutics begins Late Stage Clinical Trials”, July 20th, 2009,
http://www.econdev.uky.edu/news-yaupon.html
“Speed up Trimethyloxonium Tetrafluoroborate O-Alkylation by Adding a Solvent”, Noteworthy
Chemistry, American Chemical Society, June 29th, 2009,
http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node
_id=840&content_id=CNBP_022175&use_sec=true&sec_url_var=region1&__uuid=3b29498f8a76-47bc-acb7-126b7313c0cd
Editorial Activities
Regional Editor (U.S.A.) of the Journal of Enzyme Inhibition, 1987 - 2001.
Member of the Editorial Board, Drug Metabolism and Drug Interactions, 1987 - on.
Member of the Editorial Board, Journal of Biopharmaceutical Sciences, 1989 -1995.
Regional Editor (U.S.A.) of the Journal of Enzyme Inhibition and Medicinal Chemistry, 2002 - on
Member of Editorial Board of the AAPS PharmSciTech, 2001 - 2009.
Member of the Editorial Board of the Journal of Pharmaceutical Sciences 2001-2009.
Member of the Editorial Advisory Board of Drug Design Reviews-Online 2003-on.
Editor-in- Chief, The Open Natural Products Journal, 2009-on.
Member of the Editorila Board of Current Organic Synthesis, 2009-on.
Act as manuscript reviewer for the following research journals:
Journal of Biopharmaceutical Sciences
Journal of Pharmacy and Pharmacology
Journal of Medicinal Chemistry
Biochemical Pharmacology
Journal of Pharmaceutical Sciences
Journal of Chromatography
Journal of Chromatography-Biomedical Applications
Analytical Chemistry
The FASEB Journal
Chirality
Journal of Pharmacology and Experimental Therapeutics
Chemical Toxicology Research
Chemical Communications
19
Pharmaceutical Research
Pharmaceutical Development and Technology
Tetrahedron
Drug Metabolism and Drug Interactions
AAPS Pharmaceutical Science and Technology
Biomarkers
Industrial Crops and Products
European Journal of Medicinal Chemistry
Bioorganic and Medicinal Chemistry Letters
Biorganic and Medicinal Chemistry
Cell Biology International
Molecular and Cellular Biochemistry
Life Sciences
Phytochemical Analysis
Chemistry Letters
Entrepreneurial Activities
Companies founded:
DeNovo, Inc., 1995-1998.
Founding Scientist, President and CEO
Yaupon Therapeutics, Inc., 2002-present.
Founding Scientist and Chief Scientific Officer
Leuchemix, Inc., 2003-present
Founding Scientist
Genesis Molecular Discovery, Inc., 2004-2006
Founding Scientist
Emagin, Inc., 2007-present
Founding Scientist
Milando, Inc., 2007-present
Founding Scientist
Scientific Advisory Boards
Alternative Tobacco Products, Inc., Member, 1996-2004
KP Pharmaceuticals, Member, 1997-on
Yaupon Therapeutics, Chairman, Inc. 2002-on
Pradama, Inc., Member, 2006-on
Insys Therapeutics, Inc. 2007-on
20
Bent Creek Institute, North Carolina, 2008-on
Expert Witness
Expert Witness for the Patented Medicine Prices Review Board, Government of Canada,
Ottawa, Canada, June, 2000.
Expert Witness, Vanderbilt University, TN, January, 2008.
21
XI.
Invited Research Seminars
"Analysis of polyoxyethylene sorbitan esters by proton magnetic resonance and mass
spectrometry," Pharmaceutical Society of Great Britain, Pharmaceutical Analysis Group Meeting,
May, 1973, Bloomsbury Square, London, UK.
"Some aspects of the chemistry of aromatic triones," Research Seminar, April, 1975, University
of Naples, Department of Pharmaceutical Chemistry and Toxicology, April, 1975, Italy.
"Structure-activity studies in a series of conformationally restricted phenethylamines," University
of Yale, Sterling Hall of Medicine, Department of Pharmacology, Research Seminar, December,
1977, Connecticut, USA.
"Metabolism of catecholamines in cell culture systems," Gordon Research Conferences, August,
1977, New Hampshire, USA.
"S-Tubercidinylhomocysteine - A metabolically stable inhibitor of S-adenosylmethioninedependent methyltransferases," University of London, School of Pharmacy, Research Seminar,
November, 1979, London, UK.
"In Vitro metabolism of metyrapone to an alpha-pyridone metabolite in the rat," United Kingdom
Drug Metabolism Group, Research Paper, November 1980, Manchester, UK.
"Mechanism of methyl group transfer in the catechol-O-methyltransferase reaction," University of
Bradford, School of Pharmacy, Research Seminar, February, 1981, Bradford, UK.
"Inhibition of S-adenosylmethionine-dependent methyltransferases in cultured cell systems,"
University of Wales, Institute of Science and Technology, Department of Pharmacy, Research
Seminar, March, 1981, Cardiff, UK.
"In Vivo metabolism of pyridine - species variation," United Kingdom Drug Metabolism Group,
Research Paper, April, 1981, St. Mary's Hospital, London, UK.
"Progress in the rational design of specific inhibitors of S-adenosyl-methionine dependent
methyltransferases," University of Kentucky, College of Pharmacy, Research Seminar, June,
1981, Lexington, KY, USA.
"Inhibitors of RNA methyltransferases as potential chemotherapeutic agents," University of
Kentucky Research Foundation, Mini-Forum on Anti-Tumor`Drugs and Drug DNA interactions,
May, 1981, Lexington, KY, USA.
"Rationally designed inhibitors of transmethylases," University of Kentucky, Department of
Chemistry, Research Seminar, October, 1982, Lexington, KY, USA.
"Recent studies on the mechanism and inhibition of biological methylation reactions," University
of Louisville, Department of Pharmacology and Toxicology, March, 1983, Louisville, KY, USA.
"Rigid Analogs of Phenethylamines," Addiction Research Center, National Institute on Drug
Abuse, Department of Health and Human Services, March, 1983, Lexington, KY, USA.
22
"S-Adenosylmethionine-Dependent N-Methyltransferases." Section on Enzymes and Cellular
Biochemistry, National Institutes of Arthritis, Diabetes and Digestive and Kidney Diseases,
National Institute of Health, Bethesda, Maryland, October, 1984.
"Stereo-specific Nicotine Metabolism in the Guinea Pig." Department of Pharmacy, University of
Aston in Birmingham, Birmingham, Great Britain, April, 1984.
"Biotransformation of Nicotine in the Guinea Pig," Department of Pharmacy, University of
Manchester, Manchester, Great Britain, April, 1984.
"N-Methylation as a Route of Xenobiotic Metabolism".
Pharmacy, Toronto, Canada, September, 1985.
University of Toronto, Faculty of
"The Formation of Quaternary N-Methylated Biotransformation Products -Studies Using Nicotine
as a Model Xenobiotic", Department of Pharmacology, Medical Center, University of Kentucky,
Lexington, Kentucky, February, 1986.
"Recent Studies on the Metabolism of Nicotine", R.J. Reynolds Tobacco Company, WinstonSalem, North Carolina, June, 1986.
"Mechanism-based Methyltransferase Inhibitors", G.D. Searle and Company, Research and
Development Division, Skokie, Illinois, August, 1986.
"Stereochemistry of Drugs and Drug Metabolism", 40th National Meeting of the Association of
Official Racing Chemists, Lexington, Kentucky, April, 1986.
"Effect of Nicotine on Histamine Metabolism in the Guinea Pig", National Institutes of Health,
National Heart, Lung and Blood Institute, Workshop on the Effects of Tobacco Smoke on
Pulmonary Cells and Synthesis and Regulation of Pulmonary Macromolecules, Bethesda,
Maryland, May, 1986.
"One-Carbon Transfer Reactions in Xenobiotic Metabolism", Graduate Center for Toxicology,
University of Kentucky, Lexington, KY, November 1987.
"Chirodiastaltic Effects in Radiotracer Studies", Bristol Myers Co., Drug Metabolism and
Pharmacokinetics Division, Syracuse, NY, USA, May, 1988.
"Metabolic Rates and Processes in the Lung", Invited Speaker, Symposium on Respiratory Drug
Delivery, University of Kentucky, Lexington, KY, USA, May, 1988.
"Sulphonium Salts", Invited Keynote Speaker, First International Symposium on Sulphur
Xenobiochemistry, London, UK, September, 1988.
"Methyltransferases: Mechanisms, Inhibitor Design, and Role in Drug Metabolism", Department
of Pharmacology, Medical Center, University of Kentucky, Lexington, KY, USA, September,
1988.
"Methyltransferases: Enzyme Mechanism, Inhibitor Design, and Opportunities for Drug
Discovery", Department of Pharmacy, University of Sydney, New South Wales, Australia,
November, 1988.
23
"Mechanism-Based Approach to Methyltransferase Inhibition", Southern Research Institute,
Birmingham, AL, USA, January, 1989.
"Peptidases of the Nasal and Respiratory Tracts".
Invited Speaker, Department of
Pharmaceutics - New Product Development, Rorer Pharmaceuticals, Fort Washington, PA,
USA, March, 1989.
"The Role of Peptidases of the Nasal and Respiratory Tract in the Bioavailability of Nasally
Administered Peptides". Invited Speaker, Eighth Annual Robert S. Roxman Memorial
Symposium, Drug Metabolism Discussion Group, Fort Washington, PA, June 1989.
"Lung Peptidases and their Activities". Invited Speaker, Second International Symposium on
Respiratory Drug Delivery, Keystone, CO, U.S.A., March, 1990.
"Nicotine Metabolism Studies". Invited Speaker, R.J. Reynolds Tobacco Company, WinstonSalem, North Carolina, November, 1990.
"Studies on SAM-dependent Methyltransferases with Special Emphasis on Drug Discovery and
Xenobiotic Biotransformation". Invited Speaker, Department of Biochemistry, Loyola University,
Chicago, Illinois, November, 1990.
"DNA Analogs Containing Sulfonate Ester and Sulfonamide Internucleoside Linkages". Invited
Presentation, International Conference on Nucleic Acid Therapeutics, International Union of
Biochemistry, Clearwater Beach, Florida, January, 1991.
"Stereoselectivity in Nicotine Biotransformation Pathways" Invited Speaker, First R.J. Reynolds
Research Seminar, Department of Chemistry, Wake Forest University, Winston-Salem, North
Carolina, February, 1991.
"N-Oxidation, N-Demethylation and N-Conjugation Reactions of Nicotine". Invited Presentation,
International Symposium on the Absorption, Distribution, Metabolism and Excretion of Nicotine
and Related Compounds, IUTOX Satellite Meeting, Salsomaggiore Terme, Italy, June 1992.
"Nicotine Metabolism and CNS Activity of Nicotine Metabolites", Invited Research Seminar,
University of Louisville, Department of Pharmacology, January, 1993.
"Chirodiastaltic Phenomena in Radiochromatography: A Potentially Useful Tool for Detecting
Stereoselective Processes in Drug Metabolism" Invited Speaker, CIBA-GEIGY Corporation,
Ardsley, New York, March, 1993.
"Synthesis of Nicotine Analogs as Potential Anti-Alzheimer Compounds". Invited Speaker and
Participant, Nicotine Pharmacology and Neurodegenerative Diseases Conference, R. J.
Reynolds Tobacco Company, Winston-Salem, N. C., May, 1993.
“Chemical and Physical Properties of 2S, 6R, 8S-(-)-Lobeline.”Invited Speaker, Dynagen, Inc.,
Massachussets, Cambridge, March, 1994.
“Quality Control Issues in the Formulation of Lobeline.” Invited Speaker, Bristol-Myers, Hillside,
New Jersey, May, 1994.
24
"Morphine-6-O-sulfate Analogs as Potent, Centrally Active Analgesics". MCP Division Seminar,
College of Pharmacy, University of Kentucky, Lexington, Kentucky, March, 1995.
"Medicinal Chemistry of Nicotinoids". Targacept, Inc., Winston-Salem, N.C., July, 1997.
"3-O-Acylmorphine-6-O-Sulfate Esters: Potent, Centrally Acting Morphine Derivatives". Invited
Presentation, American Chemical Society National Meeting, Division of Chemical Toxicology,
Las Vegas, Nevada, September, 1997.
“Polar, Centrally Acting Morphine Conjugates.” Invited Presentation, School of Pharmacy, Texas
Technical University Health Sciences, Amarillo, Texas, December, 1997.
“Synthetic Morphine Analogues as Potent Analgesics.”
Pharmaceuticals, Inc., Philadelphia, PA, April, 1999.
Invited
Presentation,
Endo
“Development of a Novel Class of Subtype Selective Nicotinic Receptor Antagonists.” Invited
Presentation, International Business Communications 2nd International Symposium on Nicotinic
Acetylcholine Receptors: Advances in Molecular Pharmacology and Drug Development,
Annapolis, MD, May, 1999.
"Drug Discovery and Medicinal Chemistry Research." Invited Lecture, Department of Physiology
and Pharmacology, Wake Forest University Medical School, Winston-Salem, NC, October,
1999.
"Converting the Nicotine Molecule from an Agonist to an Antagonist at Neuronal Nicotinic
Receptors." Center of Membrane Sciences Colloquium, University of Kentucky, Lexington, KY,
November, 1999.
"Conformationally Restrained Analogues of NONI and NDNI are Selective Antagonists at the
Putative Alpha3beta2 Nicotinic Acetylcholine Receptor (nAChR) Subtype." College on Problems
of Drug Dependence, Sixty-Second Annual Scientific Meeting, San Juan, Puerto Rico, June 1722, 2000.
"Subtype-Selective Nicotinic Receptor Antagonists", Targacept, Winston-Salem, NC, November,
2000.
“Development of Neuronal Nicotinic Acetylcholine Receptor Ligands: New Opportunities in Drug
Discovery”, College of Pharmacy, University of Tennessee, Memphis, TN, May, 2001.
"Development of Neuronal Nicotinic Acetylcholine Receptor Agonists and Antagonists", Endo
Pharmaceuticals, Inc., Philadelphia, PA, August, 2001.
“Arginine Analogues and the Sensitization of Drug-Resistant Tumor Cells”, Invited Speaker,
Sixth International Meeting on Guanidino Compounds in Biology and Medicine, Cincinnati, OH,
September, 2001.
“Development of Subtype-specific Neuronal Nicotinic Acetylcholine Receptor Ligands”, Invited
Speaker, IMD3 Symposium 2002, Louisville, Kentucky, March, 2002.
25
“Progress in the Design of Sub-type Selective Neuronal Nicotinic Receptor Ligands”,
Pharmaceutical Sciences 2002 Postgraduate Conference, College of Pharmacy, University of
Kentucky, Lexington, KY, May, 2002.
“Nicotine Analogs as Subtype-selective Ligands for Neuronal Nicotinic Acetylcholine Receptors”,
Southern Research Institute, Birmingham, AL, May, 2002.
“Lobeline and Lobeline Analogs for the Treatment of Psychostimulant Abuse”, Invited Talk,
National Institute of Drug Abuse, Rockville, MD, September, 2002.
“Development of Subtype-Selective Nicotinic Receptor Ligands as Receptor Antagonists”,
Invited Speaker, College on Problems of Drug Dependence: Special Symposium Series.
Neuronal Nicotinic Receptors and Ligands: Targets for Medication. Bal Harbor, Florida, June,
2003.
“Recent Progress in the Design of Neuronal Nicotinic Acetylcholine Receptor Ligands”.
Department of Molecular and Biomedical Pharmacology, College of Medicine, University of
Kentucky, Lexington, KY, September, 2003.
“Yaupon Therapeutics, Inc.”, First Kentucky Conference on Natural Products Innovation: A
Forum for Kentucky’s Growing Natural Products Sector, Lexington, KY, November, 2003.
“Parthenolides versus Cancer: Have You Hugged a Chrysanthemum Today?”. Invited
Presentation, Markey Cancer Center, Chandler Medical Center, University of Kentucky,
Lexington, KY, November, 2003.
“Natural Product Research and Related Entrepreneurial Activities at the College of Pharmacy,
University of Kentucky”. Kentucky Innovation Commission Meeting, Office of the New Economy,
State Capitol, Frankfort, KY, November, 2003.
“Recent Progress in the Design of Neuronal Nicotinic Acetylcholine Receptor Ligands”.
Targacept, Inc., Winston-Salem, NC, December, 2003.
“Entrepreneurial Activities in Natural Products Research at the University of Kentucky College of
Pharmacy”, Invited Speaker, 2004 Ohio Valley Affiliates for Life Sciences (OVALS) Symposium;
Life Sciences Without Boundaries: Leveraging Resources, Converging Interests, Louisville, KY,
March, 2004.
“Recent Progress in the Design of Neuronal Nicotinic Acetylcholine Receptor Ligands”,
University of Michigan College of Pharmacy, Department of Medicinal Chemistry, Invited
Research Seminar, Ann Arbor, MI, March, 2004.
“Parthenolides as Potential Treatments for Lung Cancer”, Kentucky Lung Cancer Research
Program-Early Detection and Prevention Working Group, Interstate Video-Conference,
Lexington, KY, April, 2004.
“Progress in the Identification of Novel Compounds that Block Neuronal Nicotinic Receptors”.
University of Toronto, Faculty of Pharmacy, Invited Research Seminar, Toronto, Canada, May,
2004.
26
“The Pharmacy Program at the University of Kentucky”. Invited Speaker, University of Puerto
Rico School of Pharmacy, San Juan, Puerto Rico, Invited Seminar, June, 2004.
“Development of Subtype-selective Nicotinic Receptor Ligands as Antagonists at the Dopamine
Releasing Receptor Subtype”. Invited Speaker, Nicotinic Acetylcholine Receptors Symposium,
228th American Chemical Society National Meeting, Philadelphia, PA, August, 2004.
“Development of Nicotinic Receptor Antagonists as Smoking Cessation Agents”.
Invited Research Seminar, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, March,
2005.
“Selective Antagonists of Neuronal Nicotinic Acetylcholine Receptors as Potential Smoking
Cessation Agents”. Invited Research Seminar, University of Minnesota College of Pharmacy,
Department of Medicinal Chemistry, Minneapolis, MN, June, 2005.
“Long Chain N-n-Alkylnicotinium Analogs Inhibit Nicotinic Receptors Probed by [3H]Nicotine
Binding but not [3H]Methyllycaconitine Binding to Rat Striatal Membranes”. College on Problems
of Drug Dependence, Sixty Seventh Annual Scientific Meeting, June, 2005, Orlando, Florida.
“Development of Novel nAChR Antagonists for Smoking Cessation”. Invited Research Seminar,
University of Florida, College of Medicine, Department of Pharmacology and Therapeutics,
Gainesville, FL, December, 2005.
“Recently Founded Drug Discovery Companies from UK Research”. Cabinet for Economic
Development, Frankfort, KY, May, 2006.
“Current Natural Product Drug Discovery Companies Developed in Kentucky”. Department of
Commercialization and Innovation, Frankfort, KY, July, 2006.
“When are Codrugs a Possible Solution to Difficult Formulation Problems?”. Invited Oral
Presentation, AAPS Round Table: Solving ADMET Problems with Prodrugs, Soft Drugs, and CoDrugs, Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
San Antonio, TX, November, 2006.
“The Vesicular Monoamine Transporter (VMAT) as a Target for Novel Therapeutics”. Invited
Oral Presentation, 45th Annual Meeting of the American College of Neuropharmacology,
Hollywood, FL, December, 2006.
“Parthenolide Analogs as Antileukemic Agents with Clinical Potential”. Invited Oral Presentation,
International Medicinal Chemistry Symposium, Antalya, Turkey, May, 2007.
“Drug Discovery Research in the Treatment of Psychostimulant Abuse”. Invited Keynote
Address, A. Nelson Voldeng Memorial Lecture, Thirty Fourth Annual MALTO Conference,
University of Louisiana at Monroe, LA, May, 2007.
“Discovery of Novel Agents for the Treatment of Psychostimulant Abuse”. Invited Research
Seminar, School of Pharmacy, University of West Virginia, Morgantown, WV, June, 2007.
“Structural Evolution of Simple N, N’-Alkylnicotinium Analogs: A Novel Class of Nicotinic
Receptor Agonists Inhibiting Nicotine-Evoked Neurotransmitter Release”. Invited Presentation,
27
NIDA-Supported National Cooperative Drug Discovery Groups Symposium. Building
Translational Research in Medication Development in Academia: Issues, Strategies and Tactics,
Quebec City, Canada, June, 2007.
“The Search for More Selective Neuronal Nicotinic Acetylcholine Receptor Antagonists as
Smoking Cessation Agents”. Invited speaker, Symposium on Molecular Diversity in Drug Design,
Discovery and Delivery, University of South Florida, Tampa, FL, October, 2007.
“Recent Developments in the Search for More Selective Neuronal Nicotinic Acetylcholine
Receptor Antagonists as Smoking Cessation Agents”. Invited speaker, James K. Coward
Symposium, University of Michigan, College of Pharmacy, Ann Arbor, MI, January, 2008.
“Decamethonium Analogs as Brain Deliverable Neuronal Nicotinic Acetylcholine Receptor
Antagonists for Nicotinic Addiction”. Invited speaker, Fourteenth International Pharmaceutical
Technology Symposium: Overcoming Biological Barriers in Innovative Delivery Systems,
Antalya, Turkey, September, 2008.
Keynote Address, Golden Jubilee Celebrations of the National Institute of Technology,
Warangal, India, January, 2009.
“Hybrid Drugs (Codrugs)”. Plenary Speaker, National Symposium on Recent Trends in Organic
and Medicinal Chemistry, Department of Chemistry, National Institute of Technology, Warangal,
India, January, 2009.
Freshman Address, National Institute of Pharmaceutical Sciences (NIPS), Warangal, India,
January, 2009.
“The Journey of Yaupon Therapeutics”. Invited Case Study Panelist, Wharton Entrepreneurship
Conference, 2009: Carrying Ideas to Success, Philadelphia, PA, February, 2009.
“Parthenolide and DMAPT (LC-1)”. Developmental Therapeutics Program, Markey Cancer
Center, University of Kentucky, lexington, KY, December, 2009.
“Parthenolide and its Analogs as Novel Anticancer Agents”, Tumor Board, Markey Cancer
Center, University of Kentucky, Lexington, KY, January, 2010.
28
XII.
Publications
Original Research Articles Published in Peer-Reviewed Journals [articles
cited 10 or more times (Scopus; April, 2009) are indicated in parentheses]
1.
"Thermal Indolisation of 4-Pyrimidylhydrazones and 4-Pyridylhydrazones". By Peter A.
Crooks and Brian Robinson, Chemistry and Industry (London), 1967, 547-548.
2.
"Isolation and Structure of an Indole Alkaloid of Biogenetic Interest from Tabernamontana
cumminsii". By Peter A. Crooks, Brian Robinson and George F. Smith, J. Chem. Soc.,
Chem. Comm., 1968, 1210.
3.
"Azaindoles. Part I. The Synthesis of 5-aza- and 5,7-Diazaindoles by the Non-catalytic
Thermal Indolisation of 4-Pyridyl- and 4-Pyrimidylhydrazones, respectively". By Peter A.
Crooks and Brian Robinson, Can. J. Chem.,1969, 47, 2061-2067.
4.
"The Isolation and Identification of Quininone from Cinchona ledgeriana".
Crooks and Brian Robinson, J. Pharm. Pharmacol., 1970, 22, 469-470.
5.
"The Isolation and Identification of Jollyanine from Tabernamontana cumminsii". By Peter A.
Crooks and Brian Robinson, J. Pharm. Pharmacol. 1970, 22, 471-474.
6.
"The Isolation and Identification of (-)-Apparicine from Tabernamontana cumminsii". By
Peter A. Crooks and Brian Robinson, J. Pharm. Pharmacol., 1970, 22, 799-800.
7.
"Conopharyngine Pseudoindoxyl, a New Alkaloid from Tabernamontana pachysiphon Stapf.
var. cumminsii (Stapf.) H. Huber". By Peter A. Crooks and Brian Robinson, J. Pharm.
Pharmacol., 1973, 25, 820-823.
8.
"Effects of Amphetamine, 2-Aminoindane and 2-Aminotetralin on the Concentration of Whole
Brain Noradrenaline, Dopamine, 5-Hydroxytryptamine and 5-Hydroxyindoleacetic Acid in the
Mouse". By Peter A. Crooks, Hilary J. Little and John M. H. Rees, J. Pharm. Pharmacol.,
1973, 25, 124P.
9.
"Synthesis of -Amino Alcohols via Spiro-Oxiran Intermediates". By Peter A. Crooks and
Richard Szyndler, Chemistry and Industry (London), 1973, 1111-1112.
10.
"The Determination of the Hydrophile-Hydrophobe Proton Ratio in a Series of
Polyoxyethylene Sorbitan Esters". By Peter A. Crooks, John H. Collett and Roger
Withington, Pharm. Acta Helv., 1974, 49, 274-276.
11.
"A New Synthesis of 2-Aminoindanes".
(London), 1974, 495.
12.
"Reaction of Ninhydrin with N-alkylacetamides". By Peter A. Crooks, Chemistry and Industry
(London), 1975, 176-177.
13.
"Reaction of Ninhydrin with Urea and N-substituted Ureas". By Peter A. Crooks and Trevor
Deeks, Chemistry and Industry (London), 1975, 793-794.
By Peter A.
By Peter A. Crooks, Chemistry and Industry
29
14.
"Rearrangement Products from the Reaction of Diphenyltriketone with Ureas". By Peter A.
Crooks, Trevor Deeks and Francesco DeSimone, Chemistry and Industry (London), 1976,
323-324.
15.
"The Intramolecular Condensation of 2-Acylamino-3-hydroxyphenalene-1-ones and Related
Compounds. By Peter A. Crooks, Antonio Dini and Francesco DeSimone, Rend. Accad. Sci.
Fis. Mat. Napoli, 1976, Seri 4, XLIII, 37-44.
16.
"The 13C-Nuclear Magnetic Resonance Spectra of Physostigmine and Related Compounds".
By Peter A. Crooks, Brian Robinson and Otto Meth-Cohn, Phytochemistry, 1976, 15, 19031904.
17.
"Synthesis and Antinociceptive Properties of Spiro[indan-2, 2'-pyrrolidine], Spiro-[tetralin-2,
2'-pyrrolidine] and their N-Methyl Derivatives". By Peter A. Crooks and Howard E.
Rosenberg, J. Pharm. Pharmacol., 1976, 28, 83P.
18.
"Rearrangement of the Carbobenzyloxy Group - An Example of an Oxo-Wittig
Rearrangement". By Peter A. Crooks, Ronald H. B. Galt and Zbigniew S. Matusiak,
Chemistry and Industry (London), 1976, 693-694.
19.
"Antinociceptive
and
Sympathomimetic
Activities
of
Exoand
Endo-2aminobenzonorbornene and their N-Methylated Derivatives". By Peter Burn, Peter A. Crooks
and John M.H. Rees, J. Pharm. Pharmacol., 1976 28, 80P.
20.
"The Structure of Some Reaction Products of 2, 3-Dihydrophenalene-1, 2, 3-trione with Urea
and its Homologues". By Peter A. Crooks, Trevor Deeks and Francesco DeSimone, Gazz.
Chim. Ital., 1976, 107, 353-354.
21.
"A Carbon-13 NMR Study of Benzonorbornene Isomers". By Peter K. Burn, Peter A. Crooks
and Otto Meth-Cohn, Org. Magnet. Resonance, 1978, 11, 370-372.
22.
"Synthesis of Spiro[tetralin-2, 2'-pyrrolidine] and Spiro[indan-2, 2'-pyrrolidine] Derivatives as
Potential Analgesics". By Peter A. Crooks and Howard E. Rosenberg, J. Medicin. Chem.,
1978, 21, 585-587.
23.
"Extensive Conjugation of Dopamine (3, 4-Dihydroxyphenethylamine) Metabolites in Cultured
Human Skin Fibroblasts and Rat Hepatoma Cells". By Peter A. Crooks, Xandra O.
Breakefield, Christopher H. Sulens, Carmela M. Castiglione and James K. Coward, Biochem.
J., 1978, 176, 187-196.
24.
"Catecholamine Metabolism and Drug Effects in Cultured Mammalian Cells: Analysis by
HPLC". By Peter A. Crooks, Xandra O. Breakefield and James K. Coward, Proc. 4th Int.
Catecholamine Symp., 1978, 1, 210-213.
25.
"Determination of 5-Hydroxytryptamine Metabolites in Isolated Perfused Rabbit Lung by
High-Performance Liquid Chromatography". By Peter A. Crooks, Robert N. Dreyer,
Christopher H. Sulens, C. Norman Gillis and James K. Coward, Analyt. Biochem., 1979, 93,
143-152.
30
26.
"Synthesis of 5-Hydroxy and 5, 6-Dihydroxy derivatives of Spiro[indan-2, 2'-pyrrolidine], Rigid
Analogues of Tyramine and Dopamine, Respectively". By Peter A. Crooks and Howard E.
Rosenberg, J. Chem. Soc.,Perkin Trans. I, 1979, 11, 2719-2726.
27.
"In Vitro and In Vivo Effects of S-Tubercidinylhomocysteine - a Physiologically Stable
Methylase Inhibitor". By James K. Coward and Peter A. Crooks, Transmethylation, 1979, 5,
215-224.
28.
"Metabolism of S-Adenosylhomocysteine and S-Tubercidinylhomocysteine in Neuroblastoma
Cells". By Peter A. Crooks, Robert N. Dreyer and James K. Coward, Biochemistry, 1979, 18,
2601-2610.
29.
"The Synthesis and In Vitro Pharmacological Evaluation of Some Novel Enkephalin
Analogues". By Trevor Deeks, Peter A. Crooks and Roger D. Waigh, J. Pharm. Pharmacol.,
1979, 31, 62P.
30.
“High-Performance Liquid-Chromatographic Method for the Determination of In Vitro
Metabolites of Metyrapone." By Lyaquatali A. Damani, Peter A. Crooks and John W. Gorrod,
J. Pharm. Pharmacol., 1979, 31, 95P.
31.
"Sympathomimetic Effects of Exo- and Endo-isomers of 2-Aminobenzonorbornene In Vitro
and In Vivo". By Peter Burn, Peter A. Crooks, Brian L. Ratcliffe and John M. H. Rees, J.
Pharm. Pharmacol., 1980, 32, 87-91.
32.
"Synthesis and Analgesic Properties of Some Conformationally Restricted Analogues of
Profadol". By Peter A. Crooks and Richard Szyndler, J. Medicin. Chem., 1980, 23(6), 679682.
33.
"Synthesis of 2-Amino-1, 3-dihydroxyindanes". By Peter A. Crooks, Chemistry and Industry
(London), 1980, 467-468.
34.
"5, 6- and 6, 7-Dihydroxyspiro[tetralin-1, 3'-pyrrolidine]: Conformationally Restricted
Analogues of Dopamine". By Peter A. Crooks, Richard Szyndler and Barry Cox, Pharm.
Acta Helv., 1980, 55(5), 134-137.
35.
"Stereochemical Course of the Transmethylation Catalysed by Catechol OMethyltransferase". By Ronald W. Woodard, Ming-Daw Tsai, Heinz G. Floss, Peter A.
Crooks and James K. Coward, J. Biol. Chem., 1980, 255, 9124 -9127 [25 citations].
36.
"The Role of Brain 5-Hydroxytryptamine in the Analgesic Action of Centrally Acting
Sympathomimetics". By O.T. Ginarvi, Peter Burn, Peter A. Crooks and John M. H. Rees, J.
Pharm. Pharmacol., 1980, 32, 77P.
37.
"Synthesis of N-Oxide Derivatives of Metyrapone and their Detection as In Vitro Metabolites".
By Peter A. Crooks, Lyaquatali A. Damani and David A. Cowan, J. Pharm. Pharmacol.,
1981, 33, 309-312.
38.
"Metabolism of Metyrapone. 2. Chromatographic and Mass Spectral Properties of the Noxides of Metyrapone and Metyrapol". By Lyaquatali A. Damani, Peter A. Crooks and David
A. Cowan, Biomed. Mass Spectrom., 1981, 8, 270-277.
31
39.
"Metabolism of Metyrapone. III. Formation of an α-Pyridone Metabolite by Rat Hepatic
Soluble Enzymes". By Lyaquatali A. Damani, Peter A. Crooks and David A. Cowan, Drug
Metab. Disposit., 1981, 9(3), 270-273.
40.
"Baeyer-Villiger Oxidation of Metyrapone during N-Oxide Formation". By Peter A. Crooks,
Lyaquatali A. Damani and David A. Cowan, Chemistry and Industry (London), 1981, 335336.
41.
"Synthesis of Isomeric 2-Amino-1, 3-Dihydroxyindanes from Ninhydrin". By Peter A. Crooks,
Trevor Deeks, Francesco DeSimone and Eliseo Ramundo, Chemistry and Industry (London),
1981, 392-393.
42.
"Inhibition of Bacterial DNA Methylation by S-Tubercidinylhomocysteine." By Malcolm J.
Tribe, Richard J. Pinney and Peter A. Crooks, J. Pharm. Pharmacol., 1981, 33, 80P.
43.
"Identification of Component Alkyl Chains within Commercial Samples of Benzalkonium
Chloride Mixtures by Chemical Ionisation Mass Spectrometry". By Nabil N. Daoud, Peter A.
Crooks and Peter Gilbert, J. Pharm. Pharmacol., 1981, 33, 8P.
44.
"Metabolic C- and N-Oxidation, and N-Methylation of [2-14C]Pyridine In Vivo: Determination of
Urinary Metabolites by HPLC". By Mahmoud S. Shaker, Peter A. Crooks and Lyaquatali A.
Damani, J. Pharm. Pharmacol., 1981, 33, 10P.
45.
"Alpha-Adrenoceptor Properties of Some Dihydroxybenzonorbornenes Designed as Rigid
Catecholamines". By Peter Burn, Peter A. Crooks, Christopher Waldron and Peter E. Hicks,
J. Pharm. Pharmacol., 1981, 33, 83P.
46.
"Oxidative Metabolism of Heterocyclic Ring Systems". By Lyaquatali A. Damani and Peter A.
Crooks, Invited Chapter in Metabolic Basis of Detoxification, Chapter 4, pp 69-89. Edit.
William Jakoby, John R. Bend and John Caldwell, Academic Press, Inc., New York, 1982.
47.
"The Synthesis and Analgesic Activities of Some Spiro [indan-1, 3'-pyrrolidine] Derivatives
Designed as Rigid Analogs of Profadol". By Peter A. Crooks and Richard Sommerville, J.
Pharm. Sci., 1982, 71, 291-294.
48.
"Synthesis and Dopaminergic Properties of Some Exo- and Endo-2-aminobenzonorbornenes
Designed as Rigid Analogues of Dopamine". By Peter Burn, Peter A. Crooks, Frank
Heatley, Brenda Costall, Robert J. Naylor and Virinder Nohria, J. Medicin. Chem., 1982, 25,
363-368.
49.
"High-Performance Liquid Chromatographic Analysis of the In Vivo Metabolites of 14CPyridine". By Mamhoud S. Shaker, Peter A. Crooks, and Lyaquatali A. Damani, J.
Chromatography, 1982, 237, 489-495.
50.
"Species Differences in the Metabolic C- and N-Oxidation, and N-Methylation of [14C]Pyridine In Vivo". By Lyaquatali A. Damani, Peter A. Crooks, Mamhoud S. Shaker, John
Caldwell, J. D'Souza and R. L. Smith, Xenobiotica, 1982, 12, 527-534 [13 citations].
32
51.
"Synthesis
of
7-Deazaguanine-(2-amino-3,
7-dihydropyrrolo[2,3-d]pyrimidin-4-one)
analogues substituted at C-8". By Eric Benghiat and Peter A. Crooks, Chemistry and
Industry (London), 1982, 661-662.
52.
"Synthesis of 2, 3, 3a, 8a-Tetrahydroindeno[2,1-b]pyrrole Derivatives". By Peter A. Crooks,
Francesco DeSimone and Eliseo Ramundo, J. Heterocyclic Chem., 1982, 19, 1433-1436.
53.
"Preparation of S-(3-Indolemethyl) Derivatives of Mercaptoamino Acids". By Eric Benghiat
and Peter A. Crooks, Synthesis, 1982, 12, 1033-1036.
54.
"Determination of Benzalkonium Chloride by Chemical Ionization Mass Spectroscopy". By
Nabil N. Daoud, Peter A. Crooks, Richard Speak and Peter Gilbert, J. Pharm. Sci., 1983, 72,
290-292.
55.
"Synthesis and Analgesic Properties of Two Leucine-Enkephalin Analogues Containing a
Conformationally Restrained N-Terminal Tyrosine Residue. By Trevor Deeks, Peter A.
Crooks and Roger D. Waigh, J. Medicin. Chem., 1983, 26, 762-765.
56.
"Synthesis of S-3-Indolemethyl Derivatives of 5'-Deoxy-5'-thioadenosine". By Eric Benghiat
and Peter A. Crooks, J. Heterocyclic Chem., 1983, 20, 423-425.
57.
"Synthesis
of
S-5-Pyrrolo[2,3-b]pyridinemethyl
and
S-5and
S-6-Pyrrolo[2,3d]pyrimidinemethyl Derivatives of 5'-Deoxy-5'-thioadenosine". By Eric Benghiat and Peter A.
Crooks, J. Heterocyclic Chem., 1983, 20, 677-680.
58.
"-2-Adrenoceptor Agonist Properties of Exo- and Endo-isomers of 2-Amino-6, 7dihydroxybenzonorbornenes Designed as Rigid Catecholamines".
By Peter Hicks,
Christopher Waldron, Peter Burn and Peter A. Crooks, J. Pharm. Pharmacol., 1983, 35, 9499.
59.
"Multisubstrate Adducts as Potential Inhibitors of S-Adenosylmethionine Dependent
Methylases:
Inhibition of Indole N-Methyltransferase by (5'-Deoxyadenosyl)[3-(3indolyl)prop-1-yl]methylsulfonium
and
(5'-Deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium Salts". By Eric Benghiat and Peter A. Crooks, J. Medicin. Chem., 1983, 26, 14701477.
60.
"Reaction of 2-Acetamido-3, 7-dihydropyrrolo[2,3-d]pyrimidin-4-one with Dimethylamine and
Formaldehyde. Formation of Two Isomeric Mannich Bases" By Eric Benghiat and Peter A.
Crooks, J. Heterocyclic Chem., 1983, 20, 1023-1025.
61.
"Synthesis of Endo- and Exo-2-Amino-6-hydroxybenzonorbornenes - Rigid Analogues of
Tyramine". By Peter A. Crooks and Peter Burn, Chemistry and Industry (London), 1983,
644-645.
62.
"Unexpected Phenomenon in the High-Performance Liquid Chromatographic Analysis of
Racemic 14C-Labeled Nicotine: Separation of Enantiomers in a Totally Achiral System". By
Kenneth C. Cundy and Peter A. Crooks, J. Chromatography, 1983, 281, 17-23 [31 citations].
63.
"Differential Metabolism of [2'-14C]-Nicotine and [N-14CH3]-Nicotine in the Guinea Pig".
Kenneth C. Cundy and Peter A. Crooks, J. Pharm. Pharmacol., 1983, 35, 75P.
33
By
64.
"Leucine Enkephalin Analogues Containing a Conformationally Restrained N-Terminal
Amino Acid Residue". By Trevor Deeks, Peter A. Crooks and Roger D. Waigh, J. Pharm.
Sci., 1984, 73, 457-460.
65.
"High-Performance Liquid Chromatographic Method for the Determination of N- Methylated
Metabolites of Nicotine". By Kenneth C. Cundy and Peter A. Crooks, J. Chromatogr.
Biomed. Appl., 1984, 306, 291-301 [12 citations].
66.
"Leu-Enkephalin Provokes Naloxone-Insensitive Pulmonary Vasoconstriction". By Mark N.
Gillespie, Bruce D. Bowdy, Carol N. Reinsel, Edgar T. Iwamoto and Peter A. Crooks, Life
Sciences, 1984, 34, 1177-1183.
67.
"Synthesis and Stereochemical Analysis of 2-Amino-1, 2, 3, 4-tetrahydro-1, 4methanonaphthalene-2-carboxylic acid, a Conformationally Rigid Phenylalanine Derivative".
By W. John Layton, Stanford L. Smith, Peter A. Crooks, Trevor Deeks and Roger D. Waigh,
J. Chem. Soc., Perkin Trans. I, 1984, 1283-1287.
68.
"Reaction of Dimethyloxosulphonium Methylide with Aromatic Methoxylated 1, 2, 3, 4Tetrahydronaphthalene-1-ones". By Peter A. Crooks and Richard Sommerville, Chemistry
and Industry (London), 1984, 351-352.
69.
"Inhibition of Bacterial DNA Cytosine-5-methyltransferase by S-Adenosyl-L-homocysteine
and Some Related Compounds". By Peter A. Crooks, Malcolm J. Tribe and Richard J.
Pinney, J. Pharm. Pharmacol., 1984, 36, 85-89.
70.
"Structure-Activity Evidence against Opiate Receptor Involvement in Leu5-EnkephalinInduced Pulmonary Vasoconstriction". By Peter A. Crooks, Bruce D. Bowdy, Carol N.
Reinsel, Edgar T. Iwamoto and Mark N. Gillespie, Biochemical Pharmacol., 1984, 33, 40954098.
71.
"Evidence of Stereospecificity in the In Vivo Methylation of [14C]-()-Nicotine in the Guinea
Pig". By Kenneth C. Cundy, C. Steven Godin and Peter A. Crooks, Drug Metab. Disposit.,
1984, 12, 755-759.
72.
"Stereospecific In Vitro N-Methylation of Nicotine in Guinea Pig Tissues by an SAdenosylmethionine-Dependent N-Methyltransferase" By Kenneth C. Cundy, C. Steven
Godin and Peter A. Crooks, Biochemical Pharmacol., 1985, 34, 281-284.
73.
"Stereospecific In Vivo N-Methylation of Nicotine in the Guinea Pig". By Kenneth C. Cundy,
Michio Sato and Peter A. Crooks, Drug Metab. Disposit,, 1985, 13, 175-185.
74.
"N-Methylnornicotinium Ion, a New In Vivo Metabolite of R-(+)-Nicotine". By Michio Sato and
Peter A. Crooks, Drug Metab. Disposit., 1985, 13, 348-353.
75.
"Synthesis and Pharmacological Evaluation of Aromatic Dihydroxylated Spiro[indan-1, 3'pyrrolidine] and Spiro[indan-2, 2'-pyrrolidine] Derivatives". By Richard Sommerville, Howard
E. Rosenberg, and Peter A. Crooks, J. Pharm. Sci., 1985, 74, 553-555.
34
76.
"Pulmonary Metabolism of Exogenous Enkephalins in Isolated Perfused Rat Lungs". By
Mark N. Gillespie, Jerzy W. Krechniak, Peter A. Crooks, Jack W. Olson and Ralph J. Altiere,
J. Pharmacol. Exp. Therap., 1985, 232, 675-681.
77.
"Remarkable Substrate-Inhibitor Properties of Nicotine Enantiomers towards a Guinea Pig
Lung Aromatic Azaheterocycle N-Methyltransferase". By Kenneth C. Cundy, Peter A.
Crooks and C. Steven Godin, Biochem. Biophys. Res. Commun., 1985, 128, 312-316.
78.
"High-Performance Liquid Chromatographic Analysis of Pulmonary Metabolites of Leu- and
Met-Enkephalins in Isolated Perfused Rat Lung". By Peter A. Crooks, Jerzy W. Krechniak,
Mark N. Gillespie and Jack W. Olson, J.Pharm. Sci., 1985, 74, 1010-1012.
79.
"Reaction of 5, 6-Benzobicyclo[2.2.1]hepta-2, 5-diene with Thallium(III) Nitrate." By W. John
Layton, Carolyn P. Brock, Peter A. Crooks, Stanford L. Smith and Peter Burn, J. Org. Chem.,
1985, 50, 5372-5375.
80.
"In Vitro Characteristics of Guinea Pig Lung Aromatic Azaheterocycle N-Methyltransferase".
By Kenneth C. Cundy and Peter A. Crooks, Drug Metab. Disposit., 1985, 13, 658-663.
81.
"Biotransformation of Primary Nicotine Metabolites. I: In Vivo Metabolism of R-(+)-[14CNCH3]-N-Methylnicotinium Ion in the Guinea Pig". By William F. Pool and Peter A. Crooks,
Drug Metab. Disposit., 1985, 13, 578-581.
82.
"Effect of Nicotine and N'-Nitrosonornicotine on Rat Lung and Trachea Ornithine
Decarboxylase Activity". By Jack W. Olson and Peter A. Crooks, Carcinogenesis, 1985, 6,
1517-1519.
83.
"High-Performance Liquid Chromatography with Electrochemical Detection for the
Determination of Nicotine and N-Methylnicotinium Ion". By Shaker Mousa, Abdulghani AlHoudi, Glen R. Van Loon and Peter A. Crooks, J. Chromatogr., 1985, 347, 405-410.
84.
"Inhibition of Vaccinia RNA Guanine 7-methyltransferase by Compounds Designed as
Multisubstrate Adducts". By Eric Benghiat, Peter A. Crooks, Raymond Goodwin and Fritz
Rottman, J. Pharm. Sci., 1986, 75, 142-145.
85.
"N-Methylation and Quaternization of Pyridine In Vitro by Rabbit Lung, Liver and Kidney NMethyltransferases: an S-Adenosyl-L-Methionine-Dependent Reaction". By Lyaquatali A.
Damani, Mamhoud S. Shaker, Peter A. Crooks, C. Steven Godin, and Chukwuemka G.
Nwosu, Xenobiotica, 1986, 16, 645-650.
86.
"Reevaluation of the Products of Tryptamine Catalyzed by Rabbit Liver Nmethyltransferases". By Peter A. Crooks, C. Steven Godin, Chukwuemeka G. Nwosu,
Sherry S. Ansher and William Jakoby, Biochem. Pharmacol., 1986, 35, 1600-1603.
87.
"The Ability of Amine N-Methyltransferases from Rabbit Liver to N-Methylate
Azaheterocycles". By Lyaquatali A. Damani, Mahmoud S. Shaker, C. Steven Godin, Peter
A. Crooks, Sherry S. Ansher and William Jakoby, J. Pharm. Pharmacol., 1986, 38, 547-550.
35
88.
"In Vivo Depletion of S-Adenosyl-L-homocysteine and S-Adenosyl-L-methionine in Guinea
Pig Lung after Chronic S-(-)-Nicotine Administration". By C. Steven Godin and Peter A.
Crooks, Toxicol. Letters, 1986, 31, 23-29.
89.
"A Serendipitous Synthesis of 2-Amino-cis-bicyclo[4.3.0]nonane".
Chemistry and Industry (London), 1986, 462-463.
90.
"Isolation and Characterization of N-Methyl-N'-oxonicotinium ion, A New Urinary Metabolite
of R-(+)-Nicotine in the Guinea Pig". By William F. Pool, Abdulghani A. Houdi, Lyaquatali A.
Damani, W. John Layton, and Peter A. Crooks, Drug Metab. Disposit., 1986, 14, 574-579.
91.
"Synthesis of 2-Amino-1, 2, 3, 4-tetrahydro-6, 7-dihydroxy-1, 4-methanonaphthalen-2carboxylic Acid- a Conformationally Rigid Analogue of 3, 4-Dihydroxyphenylalanine (DOPA)".
By Everett J. Horn, W. John Layton, Stanford L. Smith and Peter A. Crooks, Chemistry and
Industry (London), 1986, 615-616.
92.
"In Vitro Inhibition of Histamine Metabolism in Guinea Pig Lung by S-(-)-Nicotine". By C.
Steven Godin and Peter A. Crooks, J. Pharm. Sci., 1986, 75, 949-951.
93.
"Synthesis and Antinociceptive Properties of a Series of Exo- and Endo-6-hydroxy-2aminobenzonorbornenes". By Peter A. Crooks, Peter Burn, Robert D.E. Sewell, and Neil
Upton, J. Pharm. Sci., 1986, 75, 1010-1013.
94.
"S-Acylation of Cysteine by O-Acetylsalicylic Anhydride - A Possible Mechanism for Aspirin
Hypersensitivity?" By Hana Dannan, M. N. Khawam, Joseph B. Bogardus, Anwar A.
Hussain and Peter A. Crooks, J. Pharm. Sci., 1986, 75, 1081-1084.
95.
"N-Methylation of Phenylpyridines and Bis-pyridyls as a Potential Toxication Route: Tissue
Distribution of Azaheterocycle N-Methyltransferase Activity in the Rabbit." By C. Steven
Godin, Peter A. Crooks and Lyaquatali A. Damani, Toxicol. Lett., 1986, 34, 217-222.
96.
"Biotransformation of Primary Nicotine Metabolites II. Metabolism of 3H-S-(-)-Cotinine in the
Guinea Pig: Determination of In Vivo Urinary Metabolites by High-Performance Liquid
Radiochromatography". By Kenneth C. Cundy and Peter A. Crooks, Xenobiotica, 1987, 17,
785-792.
97.
"Perturbation of S-Adenosylhomocysteine and S-Adenosylmethionine Levels, and Inhibition
of Histamine Metabolism in the Guinea Pig, By Nicotine", Tobacco Smoking and Health,
International Symposium, Lexington, Kentucky, December, 1985; in Tobacco Smoking and
Nicotine: A Neurobiological Approach, edited by William R. Martin, Glen R. Van Loon, Edgar
T. Iwamoto, and Layten Davis, p. 500, Plenum Press, New York and London, 1987.
98.
"In Vitro and In Vivo Biomethylation of Nicotine Enantiomers", Tobacco Smoking and Health,
International Symposium, Lexington, Kentucky, December, 1985; in Tobacco Smoking and
Nicotine: A Neurobiological Approach, edited by William R. Martin, Glen R. Van Loon, Edgar
T. Iwamoto, and Layten Davis, p. 499, Plenum Press, New York and London, 1987.
99.
"Stereospecific N-Methylation of Nicotine by Intact Guinea Pig Pulmonary Alveolar
Macrophages", Tobacco Smoking and Health, International Symposium, Lexington,
Kentucky, December, 1985; in Tobacco Smoking and Nicotine: A Neurobiological Approach,
By Peter A. Crooks,
36
edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and Layten Davis, p. 497,
Plenum Press, New York and London, 1987.
100.
"A Simple and Sensitive Determination of Histamine and N-Methylhistamine in Biological
Fluids by High-Performance Liquid Chromatography with Electrochemical Detection".
Abdulghani Al-Houdi, Peter A. Crooks, Glen R. Van Loon, and Cathryn A. W. Schubert, J.
Pharm. Sci., 1987, 76, 398-401.
101.
"High Performance Liquid Chromatography of Radiolabeled Nicotine Enantiomers and their
Metabolism in the Guinea Pig to N-Methylated Products". By Peter A. Crooks and Kenneth
C. Cundy, invited chapter in "Flow-Through Radioactive Detectors in HPLC". Progress in
HPLC, Vol. 4, Edit. H. Parvez, M. Kessler and S. Parvez, V.N.U. International Science Press,
Utrecht, Holland, 1988, pp 129-147.
102.
"N-Methylation of Nicotine Enantiomers by Human Liver Cytosol". By Peter A. Crooks and
C. Steven Godin, J. Pharm. Pharmacol., 1988, 40, 153-154.
103.
"High Performance Liquid Chromatography with Electrochemical Detection for the
Determination of Nicotine in Plasma". By Chen-Yie Chien, John N. Diana and Peter A.
Crooks, J. Pharm. Sci., 1988, 77, 277-279.
104.
"Determination of Plasma Nicotine by High Performance Liquid Chromatography with
Electrochemical Detection". By Chen-Yie Chien, John N. Diana and Peter A. Crooks, LCGC, Mag. Liq. Gas Chromatogr., 1988, 6, 53-55.
105.
"Formation of Quaternary Amines by N-Methylation of Azaheterocycles with Homogenous
Amine N-Methyltransferases." By Peter A. Crooks, C. Steven Godin, Lyaquatali A. Damani,
Sherry S. Ansher and William B. Jakoby, Biochem. Pharmacol., 1988, 37, 1673-1677.
106.
"N-Methyl-N'-oxonicotinium Ion: Synthesis and Stereochemistry." By Peter A. Crooks,
William F. Pool, Lyaquatali A. Damani and Stephen A. Winkle, Chemistry and Industry
(London), 1988, 95-96.
107.
"Inhibition of Histamine N-Methyltransferase Activity in Guinea Pig Pulmonary Alveolar
Macrophages by Nicotine". By Chandrachuranan Gairola, C. Steven Godin, Abdulghani Al
Houdi, and Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 724-726.
108.
"Stereoselectivity in the N'-Oxidation of Nicotine Isomers by Flavin-Containing
Monooxygenase". By Lyaquatali A. Damani, William F. Pool, Peter A. Crooks, R. Keith
Kaderlik, and Daniel M. Ziegler, Mol. Pharmacol., 1988, 33, 702-705 [11 citations].
109.
"Equilibrium Binding of Spermine and Histamine to Salmon Sperm DNA and Poly(dGdC)".
By Stephen A. Winkle and Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 809-811.
110.
"Response of Plasma Arginine Vasopressin to Nicotine in Normal Man". By Steven R.
Goldsmith, Adriana Katz and Peter A. Crooks, Clin. Pharmacol. Ther., 1988, 44, 478-481.
111.
"Effect of Continuous Nicotine Administration on Urinary Histamine and N Methylhistamine
Levels in the Guinea Pig". By Abdulghani A. Houdi, C. Steven Godin and Peter A. Crooks,
Toxicol. Letters, 1988, 44, 161-166.
37
112.
"Biotransformation of Primary Nicotine Metabolites, III. Metabolism of R-(+)-[3H-N'-CH3;14CN-CH3]-N-methylnicotinium Acetate - The Use of Double Isotope Studies to Determine the In
Vivo Stability of the N-Methyl Groups of N-Methylnicotinium Ion". By William F. Pool and
Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 758-762.
113.
"Species Variation and Stereoselectivity in the Metabolism of Nicotine Enantiomers". By
Chukwuemeka G. Nwosu and Peter A. Crooks, Xenobiotica, 1988, 18, 1361-1372 [16
citations].
114.
"Enantioselective Metabolism During Continuous Administration of S-(-)- and R-(+)-Nicotine
Isomers in Guinea Pigs". By Chukwuemeka G. Nwosu, C. Steven Godin, Abdulghani A.
Houdi, Lyaquatali A. Damani and Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 862-869.
115.
"Kinetics and Mechanism of the Reactions of Hypochlorous Acid and Monochloramine with
N-Acetylcysteine". By Prakash Kulkarni, Anwar A. Hussain, and Peter A. Crooks, Proc.
Fourth Conference on Prog. Chem. Disinfection, 1988, 399-407.
116.
"Metabolism of the Sulphonamido Group." By Peter A. Crooks, invited chapter in "Sulphur
Drugs and Related Organic Chemicals - Chemistry, Biochemistry and Toxicology", Chapter
7, Edit. Lyaquatali A. Damani, Vol. 1, Part B, Ellis Horwood Limited, Chichester, U.K., 1989,
pp 181-194.
117.
"Sulphonium Salts." By Peter A. Crooks, invited chapter in "Sulphur Drugs and Related
Organic Chemicals - Chemistry, Biochemistry and Toxicology", Edit. Lyaquatali A. Damani,
Vol. 1, Part B, Ellis Horwood Limited, Chichester, U.K., Chapter 6, 1989, pp 155-180.
118.
"Interaction
of
Sulphur
Xenobiotics
with
S-Adenosyl-L-methionine-dependent
Methyltransferase Reactions." By Peter A. Crooks, invited chapter in "Sulphur Drugs and
Related Organic Chemicals - Chemistry, Biochemistry and Toxicology", Edit. Lyaquatali A.
Damani, Vol. 2, Part B, Ellis Horwood Limited, Chichester, U.K., Chapter 2, 1989, pp 47-85.
119.
"Nasal Absorption and Metabolism of Progesterone and 17-Estradiol in the Rat." By Rima
N. Bawarshi-Nassar, Anwar A. Hussain and Peter A. Crooks, Drug Metabol. Disposit., 1989,
17, 248-254.
120.
"N-Methylation as a Toxication Route for Xenobiotics. II. In Vivo Formation of N,N'-Dimethyl4,4'-bipyridinium Ion (Paraquat) from 4,4'-bipyridyl in the Guinea Pig". By C. Steven Godin
and Peter A. Crooks, Drug Metabol. Disposit., 1989, 17, 180-185.
121.
"Nasal Absorption of 17-Ethinyl Estradiol in the Rat". By Rima N. Bawarshi-Nassar, Anwar
A. Hussain and Peter A. Crooks, J. Pharm. Pharmacol., 1989, 41, 214-216 [14 citations].
122.
"Differential Effect of Nicotine on Plasma Norepinephrine Levels in Normal Humans and in
Patients with Congestive Heart Failure". By Steven R. Goldsmith, Donna Dodge-Brown,
Adriana Katz and Peter A. Crooks, Amer. J. Cardiology, 1989, 63, 122-123.
123.
"Synthesis of 5-Benzoyl-5-phenyl- and 5-Phenylhydroxymethyl-5-phenylhydantoins as
Potential Anticonvulsants". By Peter A. Crooks, Trevor Deeks, and Francesco DeSimone, J.
Heterocyclic Chem., 1989, 26, 1113-1117.
38
124.
"5'-Thioadenosine Derivatives as Potent and Selective Inhibitors of Histamine NMethyltransferase". By Peter A. Crooks, Samira F. Hassan, Eric Benghiat, Susan K.
Hemrick-Luecke and Ray W. Fuller, Drug Metab. Drug Interact., 1989, 7, 111-141.
125.
"Drug Application to the Respiratory Tract: Metabolic and Pharmacokinetic Considerations."
By Peter A. Crooks and Lyaquatali A. Damani, Invited Chapter in "Respiratory Drug
Delivery", Edit. Peter R. Byron, CRC Press, Inc. Cleveland, OH, USA, Chapter 3, 1990, pp
61-90.
126.
"Rearrangement of O-Acetylsalicylamides via Intramolecular O to N Transacylation: Rate
Enhancement by an Adjacent Carboxylic Acid Group". By Fatima A. Tawfig, Lewis W. Dittert,
Anwar A. Hussain and Peter A. Crooks, J. Pharm. Sci., 1990, 79, 651.
127.
"Triazolines XVII. Metabolism and Disposition of 14C-ADD 17014 [1-(4-chlorophenyl)-5-(4pyridyl)-2-1, 2, 3-triazoline], a Novel Triazoline Anticonvulsant: Preliminary Studies in the Rat".
By Terence T. Tita, Pankaja K. Kadaba, and Peter A. Crooks, J. Biopharm. Science, 1990, 1,
171-180.
128.
"Kinetics and Mechanism of Decomposition of N-Chloro--amino Acids". By Riad Awad,
Anwar A. Hussain and Peter A. Crooks, J. Chem. Soc. Perk. Trans. II, 1990, 1233-1238.
129.
"Kinetics and Mechanism of Decomposition of N-Chloro--amino Acids. II. Conformationally
Restricted Models". By Riad Awad, Anwar A. Hussain and Peter A. Crooks, J. Pharm. Sci.,
1990, 79, 1121-1122.
130.
"Kinetics of Decomposition of O-Acyl Derivatives of Salicylamide and Related Compounds".
By Fatima A. Tawfig, Lewis W. Dittert, Anwar A. Hussain, and Peter A. Crooks, International
J. Pharmaceutics., 1990, 64, 43-55.
131.
"Lung Peptidases and Their Activities". By Peter A. Crooks, Respiratory Drug Delivery II,
1991, Volume 1, pp 50-103.
132.
"Progress Toward the Synthesis of Nonionic Oligonucleotide Analogues with Sulfonate and
Sulfonamide Internucleoside Linkages". By John A. Secrist III, Peter A. Crooks, Joseph A.
Maddry, Robert C. Reynolds, Anita S. Rathore, M. Shamim Ahktar, and John A.
Montgomery. Proceedings of First International Symposium on Synthetic Oligonucleotides,
Moscow, Russia, June 24-28, 1991, Nucleic Acids Research, Symposium Series, 1991, 24,
5-8.
133.
"The Synthesis and Antiviral Activity of 5'-Amino-3'-azido-3', 5'-dideoxythymidine". By Robert
C. Reynolds, Peter A. Crooks, Joseph A. Maddry, John A. Montgomery and John A. Secrist
III, J. Biopharmaceutical Sci., 1991, 2(3), 195-203.
134.
"Kinetics and Mechanisms of Chlorine Exchange between Chloramine-T and Secondary
Amines". By Hana Dannan, Peter A. Crooks, Lewis W. Dittert, and Anwar A. Hussain, J.
Pharm. Sci., 1992, 81, 652-656.
135.
"Structure-Activity Considerations in the Kinetics and Mechanism of Chlorine Exchange
between Chloramine-T and Secondary Amines". By Hana Dannan, Anwar A. Hussain, Peter
A. Crooks, and Lewis W. Dittert, J. Pharm. Sci., 1992, 81, 657-660.
39
136.
"Inhibition of [3H]-Dopamine Uptake into Rat Striatal Slices by Quaternary N-Methylated
Nicotine Metabolites". By Linda P. Dwoskin, L. L. Leibee, Ann L. Jewell, Zhou-Xia Fang and
Peter A. Crooks, Life Sciences, 1992, 50, PL-233 - PL-237.
137.
"Nucleoside Sultones: Synthons for the Preparation of Novel Nucleotide Analogs. I.
Synthesis and Ring Opening Reactions". By Peter A. Crooks, Robert C. Reynolds, Joseph
A. Maddry, Anita Rathore, John A. Montgomery, and John A. Secrist, III, J. Org. Chem.,
1992, 57, 2830-2835.
138.
"Characterization of the Glucuronide Conjugate of Cotinine: A Previously Unidentified Major
Metabolite of Nicotine in Smoker's Urine". By William S. Caldwell, Jackie M. Greene, Gary
D. Byrd, K.M. Chang, M.S. Uhrig, J. Donald deBethizy, Balwinder S. Bhatti, Robert M. Riggs
and Peter A. Crooks, Chem. Toxicol. Res., 1992, 5, 280-285 [28 citations].
139.
"Drug Targeting to the Lung: Chemical and Biochemical Considerations". By Peter A.
Crooks, invited chapter in "Pharmaceutical Aerosol Technology", Edit. Anthony Hickey,
Marcel Dekker, Inc., NY, Chapter 4, pp 83-127, 1992.
140.
"Formation of a Novel 2, 3-Dihydro-1, 4-oxazine Nucleoside via Condensation of Adenosine
Dialdehyde with Benzylamine". By Robert M. Riggs and Peter A. Crooks, Chemistry and
Industry (London), 1992, 220-221.
141.
"Synthesis of Thymidine Dimers Containing Internucleoside Sulfonamide Linkages". By
Robert C. Reynolds, Peter A. Crooks, Joseph A. Maddry, M. Shamim Akhtar, John A.
Montgomery, and John A. Secrist, III. J. Org. Chem., 1992, 57, 2983-2985 [24 citations].
142.
"4-Trimethylammonium Antipyrine, a Quaternary Ammonium Non-Radionuclide Marker for
Blood-Brain Barrier Integrity During In Vivo Microdialysis". By David D. Allen, Peter A.
Crooks and Robert A. Yokel, J. Pharmacol. Toxicol. Methods, 1992, 28, 129-135 21
citations].
143.
"Enantiomeric Purity of Nicotine in Tobacco Smoke". By Peter A. Crooks, C. Steven Godin
and William F. Pool, Med. Sci. Res., 1992, 20, 879-880 [13 citations].
144.
"Oxidative Metabolism of Nicotine Enantiomers in Cultured Guinea Pig Hepatocytes". By
Peter A. Crooks, Amanda J. Sherratt, and C. Steven Godin, Med. Sci. Res., 1992, 20, 909911.
145.
"Synthesis of N-Glucuronic Acid Conjugates of Cotinine, cis-3-Hydroxycotinine, and trans-3'Hydroxycotinine". By Peter A. Crooks, Balwinder S. Bhatti, Alain Ravard, Robert M. Riggs
and William S. Caldwell, Med. Sci. Res., 1992, 20, 881-883.
146.
"N-Oxidation, N-Methylation and Conjugation Reactions of Nicotine". By Peter A. Crooks,
invited chapter in "Biochemistry and Metabolism of Nicotine and Related Alkaloids", Edit.
John W. Gorrod and John Wahren, Chapman Hall, London, Chapter 5, pp 81-109, 1993.
147.
"S(-)-Nornicotine Increases Dopamine Release in a Calcium-Dependent Manner from
Superfused Rat Striatal Slices". By Linda P. Dwoskin, Susan T. Buxton, Ann L. Jewell and
Peter A. Crooks, J. Neurochem., 1993, 60, 2167-2174 [25 citations].
40
148.
"Conformational Studies of the Thymidine Dimers Containing Sulfonate and Sulfonamide
Linkages by NMR Spectroscopy". By C. Glemarec, Robert C. Reynolds, Peter A. Crooks,
John A. Maddry, M.S. Akhtar, John A. Montgomery, John A. Secrist, III, and J.
Chattopadhyaya, Tetrahedron, 1993, 49, 2287-2298.
149.
"Triazolines 24. Permanganate-Catalyzed Low Temperature Thermolysis of 2-1, 2, 3Triazolines". By Pankaja K. Kadaba, Gordon Parmley, Peter A. Crooks and Bushra J. Agha,
J. Heterocyclic Chem., 1993, 30, 1191-1196.
150.
"Detection of a Possible Biomarker for Sidestream Cigarette Smoke Exposure". By
Abdulghani A. Houdi, C. Steven Godin and Peter A. Crooks, Pharm. Sci. Commun., 1993, 4,
15-20.
151.
"Chloramine-T in Radiolabelling Techniques". I. Kinetics and Mechanism of the Reaction
between Chloramine-T and Amino Acids. By Anwar A. Hussain, Riad Awad, Peter A. Crooks
and Lewis W. Dittert, Analyt. Biochem., 1993, 214, 495-499.
152.
"Gas Chromatographic Determination of Residual Levels of t-Butanol from Lyophilized
Liposomal Formulations". By Prasad V. Gogineni, Peter A. Crooks and Ram B. Murty, J.
Chromatogr. Biomed. Appl., 1993, 620, 83-88.
153.
"Nornicotine-Induced Dopamine Release from Rat Striatal Slices is ConcentrationDependent, Calcium-Dependent and Stereoselective". By Linda P. Dwoskin, Susan T.
Buxton, LiHong Teng and Peter A. Crooks, National Institute on Drug Abuse, Research
Monograph, 1993, Series 141, 249.
154.
"Direct Determination of Cotinine-N-Glucuronide in Urine Using Thermospray Liquid
Chromatography/Mass Spectrometry". By Gary D. Byrd, M.S. Uhrig, William S. Caldwell, J.
Donald deBethizy, Peter A. Crooks, Alain Ravard, and Robert M. Riggs, Biological Mass
Spectrom.,1994, 23, 103-107 [15 citations].
155.
"Modern Instrumental Methods for Studying Mechanisms of Toxicity". By William S.
Caldwell, J. Donald deBethizy, Peter A. Crooks and Gary D. Byrd, Invited Chapter in:
Principles and Methods in Toxicology, Third Edition, A. Wallace Hayes ed., Chapter 37, New
York, Raven Press, pp. 1335 - 1390, 1994.
156.
"Synthesis of [Methyl-d3]-Labeled Cis- and Trans-3'-Hydroxycotinine". By Alain Ravard and
Peter A. Crooks, J. Labelled Comp. Radiopharm., 1994, 34, 1001-1009.
157.
"Lobeline Robustly Increases Tritiated Dopamine Release from Rat Striatal Slices". By Linda
P. Dwoskin, LiHong Teng, Susan T. Buxton and Peter A. Crooks, National Institute on Drug
Abuse, Research Monograph, 1994, Series 142, 191.
158.
"Design of Novel Prodrugs for the Enhancement of the Transdermal Penetration of
Indomethacin". By Janan A. Jona, Lewis W. Dittert, Peter A. Crooks and Anwar A. Hussain,
Int. J. Pharm., 1995, 123, 127-136 [12 citations].
159.
"Synthesis of 2-Cyanomethyl-1-methylpiperidine". By Niranjan M. Deo and Peter A. Crooks,
Synth. Commun., 1995, 25 (5), 691-701.
41
160.
"A Novel Polymeric Spermine Conjugate Inhibits Polyamine Transport in Pulmonary Artery
Smooth Muscle Cells". By Shewan M. Aziz, Michael P. Gosland, Peter A. Crooks, Jack W.
Olson and Mark N. Gillespie, J. Pharmacol. Exp. Therap.,1995, 274, 181-186 [24 citations].
161.
"Minor Alkaloids of Tobacco Release [3H]-Dopamine from Superfused Rat Striatal Slices".
By Linda P. Dwoskin, LiHong Teng, Susan T. Buxton, Alain Ravard, Niranjan Deo, YingShi
Guo and Peter A. Crooks, Eur. J. Pharmacol., 1995, 276, 195-199 [20 citations].
162.
"Kinetics and Mechanism of Hydrolysis of Amidals: Their Relative Stability Compared to
Structurally Related Acetals and Acylals." By Jianbing Chen, Peter A. Crooks, and Anwar
Hussain, Int. J. Pharmac., 1995, 123, 95-101.
163.
"Inhibition of Nicotine-Evoked Dopamine Release by Pyridino N-Substituted Nicotine
Analogues: A New Class of Nicotinic Antagonist". By Peter A. Crooks, Alain Ravard, Li
Hong Teng, and Linda P. Dwoskin, Drug Development Res., 1995, 36, 71-82 [37 citations].
164.
"Combination Therapy with 5-Fluorouracil and L-Canavanine: In Vitro and In Vivo Studies".
By Diane S. Swaffar, Choo Y. Ang, Pankaj B. Desai, Deborah A. Thomas, Peter A. Crooks,
William J. John, and Gerald A. Rosenthal, Anti-Cancer Drugs, 1995, 6, 586-593 [24
citations].
165.
"Determination of Nicotine Metabolites in Rat Brain after Peripheral Radiolabeled Nicotine
Administration: Detection of Nornicotine ". By Peter A. Crooks, Min Li, and Linda P.
Dwoskin, Drug. Metab. Disposit., 1995, 23(10), 1175-1177 [20 citations].
166.
"Insecticidal Properties of Some L-Canavanine Derivatives". By Gerald A. Rosenthal, D. L.
Dahlman, Peter A. Crooks, Supinan NaPhuket and Latch S. Trifonov. J. Agr. Food Chem.,
1995, 43, 2728-2734 [10 citations].
167.
"Sustained Release of Synergistic Agents". By Hong Guo, Tadeusz Cynkowski, Grazyna
Cynkowska, Peter A. Crooks, and Paul Ashton, Proc. Int. Symp. Controlled Release Bioact.
Mater., 1995, 22, 326-327.
168.
“Disease Enhanced Delivery from Erodable Implants”. By Paul Ashton, Hong Guo, Grazyna
Cynkowska, Tadeusz Cynkowski, and Peter A. Crooks, Proc. Int. Symp. Controlled Release
Bioact. Mater., 1995, 22, 163-164.
169.
"Large Scale Production and Chemical Characterization of the Protective, Higher Plant
Allelochemicals: L-Canavanine and L-Canaline". By Michael Bass, Peter A. Crooks, H. Levi,
Supinan NaPhuket, and Gerald A. Rosenthal. Biochem. System Ecol., 1995, 25, 717-721
[13 citations].
170.
"Reactions of N-Benzoyl Amino Acids with Oxalyl Chloride: A Facile Route to 4-Substituted
2-Phenyloxazole-5-carboxylates". By Peter A. Crooks, Grazyna Cynkowska, Paul Ashton,
and Tadeusz Cynkowski, J. Chem. Soc., Chem. Comm., 1995, (22), 2335-2337.
171.
"A Dihydromorphine-6-O-sulfate". By Carolyn Pratt Brock, Santosh Kottayil, D. Allan
Butterfield, and Peter A. Crooks, Acta Crystallogr., 1996, C52, 122-125.
42
172.
"3-O-Acetylmorphine-6-O-sulfate: A Potent, Centrally Acting Morphine Derivative". By
Abdulghani A. Houdi, Santosh Kottayil, Peter A. Crooks and D. Alan Butterfield, Pharmacol.
Biochem. Behavior, 1996, 53, 665-671.
173.
"Reversal of Doxorubicin, Etoposide, Vinblastine, and Taxol Resistance in Multidrug
Resistant Human Sarcoma Cells by a Polymer of Spermine". By Michael P. Gosland, Mark
N. Gillespie, Clifford P. Tsuboi, Sharmen Tofiq, Jack W. Olson, Peter A. Crooks and Shewan
M. Aziz, Cancer Chemother. Pharmacol., 1996, 37, 593-600 [13 citations].
174.
"Chiral Purity Determination of Tobacco Alkaloids and Nicotine-Like Compounds by 1H-NMR
Spectroscopy in the Presence of 1, 1'-Binaphthyl-2, 2'-diylphosphoric Acid". By Alain Ravard
and Peter A. Crooks, Chirality, 1996, 8 (4), 295-299 [14 citations].
175.
"The Potential of a Novel Polyamine Transport Inhibitor in Cancer Chemotherapy". By
Shewan M. Aziz, Mark N. Gillespie, Peter A. Crooks, Sharmen Tofiq, Clifford P. Tsuboi, Jack
W. Olson, and Michael P. Gosland, J. Pharmacol. Exp. Therap., 1996, 278, 185 – 192 [19
citations].
176.
"Regioselective Alkylation of N-(Diphenylmethylidene)-3-(aminomethyl)-pyridine: a Simple
Route to Minor Tobacco Alkaloids and Related Compounds." By Niranjan M. Deo and Peter
A. Crooks, Tetrahedron Letters, 1996, 37(8), 1137-1140 [12 citations].
177.
"Neurochemical Characterization of a New Class of Novel Nicotinic Receptor Antagonist". by
Peter A. Crooks, Lincoln H. Wilkins, Li-Hong Teng, Alain Ravard, and Linda P. Dwoskin,
National Institute on Drug Abuse, Research Monograph, 1996, Series 162, 286.
178.
"Behavioral Sensitization to Nornicotine: Lack of Correlation with [3H] Nicotine Binding in
Rat Whole Brain". By Linda P. Dwoskin, Lincoln H. Wilkins, Peter A. Crooks, M. C. Bradley,
and Michael T. Bardo, National Institute on Drug Abuse, Research Monograph, 1996, Series
162, 311.
179.
"Structure-Activity Studies of L-Canaline-Mediated Inhibition of Porcine Glutamic-Pyruvic
Aminotransferase". By David R. Worthen, Darian K. Ratliff, Gerald A. Rosenthal, L.Trifonov,
and Peter A. Crooks, Chem. Res. Toxicol., 1996, 9, 1293-1297.
180.
"Intravitreal Sustained Release Corticosteroid-5-Fluorouracil Conjugate in the Treatment of
Experimental Proliferative Vitreoretinopathy." By Adam S. Berger, Chang-Kuo Cheng, P.
Andrew Pearson, Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazina Cynkowska,
and Glenn J. Jaffe, Invest. Ophthalmol. Vis. Sci., 1996, 37(11), 2318-2325 [45 citations].
181.
"Lobeline and Nicotine Evoke [3H]-Overflow from Rat Striatal Slices Preloaded with
[3H]Dopamine: Differential Inhibition of Synaptosomal and Vesicular [3H]Dopamine Uptake".
By Li Hong Teng, Peter A. Crooks, Patricia K. Sonsalla, and Linda P. Dwoskin, J.
Pharmacol. Exp. Ther., 1997, 80, 1432-1444 [68 citations].
182.
"Metabolites of Nicotine in Rat Brain After Peripheral Nicotine Administration: Cotinine,
Nornicotine and Norcotinine". By Peter A. Crooks, Min Li, and Linda P. Dwoskin, Drug.
Metab. Disposit.,1997, 25(1), 47-54 [41 citations].
43
183.
"Nicotinic-Receptor Mediation of S(-)Nornicotine-Evoked [3H]-Overflow from Rat Striatal
Slices Preloaded with [3H]-Dopamine". By Li Hong Teng, Susan T. Buxton, Peter A. Crooks,
and Linda P. Dwoskin, J. Pharmacol. Exp. Ther., 1997, 283, 778-787 [36 citations].
184.
"Cotinine Pharmacology: Brain Uptake and Metabolism, Effects on Dopamine Release and
Lack of Behavioral Sensitization after Chronic Administration to Rats". By Peter A. Crooks,
LiHong Teng, Min Li, Michael T. Bardo, Lincoln H. Wilkins, and Linda P. Dwoskin, National
Institute on Drug Abuse, Research Monograph, 1997, Series 174, 203.
185.
"Further Characterization of a Novel Class of Nicotinic Receptor Antagonists". By Linda P.
Dwoskin, M. Imad Damaj, David D. Allen, Lincoln H. Wilkins, and Peter A. Crooks, National
Institute on Drug Abuse, Research Monograph, 1997, Series 174, 65.
186.
"Contribution of CNS Nicotine Metabolites to the Neuropharmacological Effects of Nicotine
and Tobacco Smoking". By Peter A. Crooks and Linda P. Dwoskin, Biochem. Pharmacol.,
1997, 54, 743-753 [49 citations].
187.
"(-)-Nornicotine Partially Substitutes for (+)-Amphetamine in a Drug Discrimination Paradigm
in Rats." By Michael T. Bardo, R. A. Bevins, Jennifer E. Klebaur, Peter A. Crooks, and Linda
P. Dwoskin, Pharmacol. Biochem. Behav., 1997, 58(4), 1083-1087 [19 citations].
188.
"Synthesis and Structure-Activity Studies of Some Antitumour Congeners of L-Canavanine".
By Supinan R. NaPhuket, Latchezar S. Trifanov, Peter A. Crooks, Gerald A. Rosenthal,
James W. Freeman, and William E. Strodel, Drug Development Research, 1997, 40, 325332.
189.
"Measurement of Adenosine Concentration in Aqueous and Vitreous". By Michelle Howard,
Harsha A. Sen, Seema Capoor, Rob Herfel, Peter A. Crooks, and Myron K. Jacobson, Inv.
Ophthalmol. Vis. Sci., 1998, 39(10), 1942-1946.
190.
"A Novel Technique for Visualizing the Intracellular Localization and Distribution of
Transported Polyamines in Cultured Pulmonary Artery Smooth Muscle Cells". By Shewan M.
Aziz, Mustafa Yatin, David W. Lipke, David R. Worthen, and Peter A. Crooks, J. Pharm.
Biomed. Anal., 1998, 17, 307-320 (1999 Outstanding Manuscript Award in Analysis and
Pharmaceutical Quality, American Association of Pharmaceutical Scientists) [15
citations].
191.
"Lobeline Displaces [3H]Dihydrotetrabenazine Binding and Releases [3H]Dopamine from Rat
Striatal Synaptic Vesicles: Comparison with d-Amphetamine". By LiHong Teng, Peter A.
Crooks and Linda P. Dwoskin, J. Neurochem., 1998, 71, 258-265 [41 citations].
192.
"The Heterocyclic Substituted Pyridine Derivative ()-2-Azabibicyclo[2.2.1]hept-5-ene (RJR2429); a Selective Ligand at Nicotinic Acetylcholine Receptors". By Merouane Bencherif,
Jeffrey D. Schmitt, Balwinder S. Bhatti, Peter A. Crooks, William S. Caldwell, M. E. Lovette,
K. Fowler, L. Reeves, and Patrick M. Lippiello, J. Pharmacol. Exp. Ther., 1998, 284, 886-894
[35 citations].
193.
"The In Vitro Anti-tumor Activity of Some Crude and Purified Components of Black Seed,
Nigella sativa L". By David R. Worthen, Omar A. Ghosheh, and Peter A. Crooks, Anticancer
Research, 1998, 18, 1527-1532 [94 citations].
44
194.
"A Unique Interaction between Polyamine and MDR (P-Glycoprotein) Transporters in
Cultured Chinese Hamster Ovary Cells Transfected with Mouse mdr-1 Gene". By Shewan
M. Aziz, David R. Worthen, Ken Ain, and Peter A. Crooks, Biochem. Pharmacol., 1998, 56,
181-187.
195.
"L-Canavanine Modulates Cellular Growth, Chemosensitivity, and P-glycoprotein Substrate
Accumulation in Cultured Human Tumor Cell Lines". By David R. Worthen, Lynn Chien,
Clifford P. Tsuboi, Xi Y. Mu, and Peter A. Crooks, Cancer Letters, 1998, 132, 229-239.
196.
"Synthesis of (E)-[Methyl-d3]-4-(pyridinyl)-3-buten-1-amine; a Deuterated Analogue of the
Tobacco Alkaloid and Nicotine Metabolite: Metanicotine." By Peter A. Crooks, Alain Ravard
and Gary D. Byrd, J. Labelled Comp. Radiopharm., 1998, LXI, 1165-1171.
197.
"Interactions of Lobeline and Nicotine with Amphetamine: In Vitro DA Release and Drug
Discrimination in Rats." Linda P. Dwoskin, Jane B. Acri, Peter A. Crooks, LiHong Teng and
Jeffrey M. Witkin, National Institute on Drug Abuse, Research Monograph, 1998, 179, 68.
198.
"Increased Concentrations of Plasma Cotinine in Schizophrenic Smokers Compared to
Normal smokers." Peter A. Crooks, Omar Ghosheh, Linda P. Dwoskin, Thea
Rogers,
and Jose de Leon, National Institute on Drug Abuse, Research Monograph, 1998, 179, 192.
199.
"Development of a Novel Class of Subtype-Selective Nicotinic Receptor Antagonists:
Pyridine N-Substituted Nicotine Analogues". By Linda P. Dwoskin, Lincoln H. Wilkins, James
R. Pauly, and Peter A. Crooks, Molecular and Functional Diversity of Ion Channels and
Receptors; Ann. New York Acad. Sci. (Special Issue), Edit., Bernado Rudy and Peter
Seeburg, 1999, 868, 617-619 [13 citations].
200.
"Acute and Chronic Effects of Nornicotine on Locomotor Activity in Rats: Cross-Reactivity to
Nicotine." By Linda P. Dwoskin, Peter A. Crooks, Melinda B. Marion, LiHong Teng, and
Michael T. Bardo, Psychopharmacology, 1999, 145, 442-451 [23 citations].
201.
"S-(-)-Cotinine, the Major Brain Metabolite of Nicotine, Stimulates Nicotinic Receptors to
Evoke [3H]Dopamine Release from Rat Striatal Slices in a Calcium-Dependent Manner". By
Linda P. Dwoskin, LiHong Teng, Susan T. Buxton, and Peter A. Crooks, J. Pharmacol. Exp.
Therap., 1999, 288, 905-911 [23 citations].
202.
"A Novel Enantioselective Synthesis of (S)-(-)- and (R)-(+)-Nornicotine via Alkylation of a
Chiral 2-Hydroxy-3-pinanone Ketimine Template." By Jason H. Swango, Balwinder S. Bhatti,
Muhammad M. Qureshi, and Peter A. Crooks, Chirality, 1999, 11, 316-318 [12 citations].
203.
"High Performance Liquid Chromatographic Analysis of the Pharmacologically Active
Quinones and Related compounds in the Oil of the Black Seed (Nigella sativa L.). By Omar
A. Ghosheh, Abdulghani A. Houdi, and Peter A. Crooks, J. Pharm. Biomed. Anal., 1999, 19,
757-762 [43 citations].
204.
"Chemical Properties of Nicotine and Other Tobacco Related Compounds". By Peter A.
Crooks, Invited Chapter in "Analytical Determination of Nicotine and Related Compounds
and their Metabolites", Edits. John W. Gorrod and Peyton Jacob III, Elsevier, Oxford, pp 69147, 1999.
45
205.
"Use of High-Performance-Liquid Chromatographic and Mass Spectrometric Techniques for
the Determination of Nicotine and its Metabolites". By Peter A. Crooks and Gary D. Byrd,
invited chapter in "Analytical Determination of Nicotine and Related Compounds and their
Metabolites", Edits. John W. Gorrod and Peyton Jacob III, Elsevier, Oxford, pp 225-264,
1999.
206.
"Synthesis and Structure-Activity Studies of Some Antitumour Congeners of L- Canaline".
By Supinan R. Na Phuket, Latchezar S. Trifonov, Chongxi Yu, David R. Worthen, Peter A.
Crooks, Gerald A. Rosenthal, and James W. Freeman, Drug Development Research, 1999,
47(4), 170-177.
207.
“Synthesis of Heterocyclic Substituted Pyridine Analogs as Potential Therapeutics for
Neurodegenerative Diseases”. By Haeil Park and Peter A. Crooks, Proceedings of the
Korean Society of Applied Pharmacology, 1999, 4, pp1-4.
208.
"Nornicotine is Self-Administered Intravenously by Rats". By Michael T. Bardo, Thomas A.
Green, Peter A. Crooks, and Linda P. Dwoskin, Psychopharmacology, 1999, 146, 290-296
[40 citations].
209.
"Residence Times and Half-Lives of Nicotine Metabolites in Rat Brain after Acute Peripheral
Administration of [2’-14C]Nicotine". By Omar Ghosheh, Linda P. Dwoskin, Wen-kui Li, and
Peter A. Crooks, Drug Metab. Disposit., 1999, 27, 1448-1455 [39 citations].
210.
"Stereochemically Defined Lobeline Analogues: Inhibition of [3H]Dopamine Uptake and [3H]Nicotine Binding in Rat Striatum." Peter A. Crooks, Marlon D. Jones, M. Dathan Chesnut, A.
M. Jaromczyk, and Linda P. Dwoskin, National Institute on Drug Abuse, Research
Monograph, 1999, 180, 234.
211.
"Nornicotine Evokes [3H] Overflow from Rat Nucleus Accumbens Slices Preloaded with
[3H]Dopamine." Thomas A. Green, Michael T. Bardo, Peter A. Crooks, Aaron J. Haubner,
and Linda P. Dwoskin, National Institute on Drug Abuse, Research Monograph, 1999, 180,
195.
212.
“Pharmacolological Similarities between Native Brain and Heterologously Expressed
42Nicotinic Receptors”. By Navid Shafaee, McCann Houng, Anthony Troung, Nareerat
Viseshakul, Antonio Figi, Sumandeep Sandhu, John R. Forsyeth, Linda P. Dwoskin, Peter A.
Crooks, and Bruce N. Cohen, Brit. J. Pharmacol., 1999, 128, 1291-1299 [18 citations].
213.
"Modern Instrumental Methods for Studying Mechanisms of Toxicity". By William S. Caldwell,
J. Donald deBethizy, Peter A. Crooks and Gary D. Byrd, Invited Chapter in: Principles and
Methods of Toxicology, Fourth Edition, Edit. A. Wallace Hayes, Chapter 36, Taylor and
Francis, Philadelphia, pp 1689-1757, 2000.
214.
"Direct Determination of Nicotine-N-Glucuronide in Human Biological Samples." By Gary D.
Byrd, William S. Caldwell, Peter A. Crooks, Alain Ravard, and Balwinder S. Bhatti, Drug
Metab. Drug Interact., 2000, 16, 281-297.
215.
"A Simple High Performance Liquid Chromatographic Method for the Quantification of Total
Cotinine, Total 3'-Hydroxycotinine, and Caffeine in the Plasma of Smokers." By Omar A.
Ghosheh, Debra Browne, Thea Rogers, Jose de Leon, Linda P. Dwoskin, and Peter A.
46
Crooks, Journal of Pharmaceutical and Biomedical Analysis, 2000, 23, 543-549 [25
citations].
216.
"Nornicotine Pretreatment Decreases Intravenous Nicotine Self-Administration in Rats". By
Thomas A. Green, S. B. Phillips, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo,
Psychopharmacology, 2000, 152, 289-294 [11 citations].
217.
"Recent Developments in Neuronal Nicotinic Acetylcholine Receptor Antagonists". By Linda
P. Dwoskin, Xu Rui, Joshua Ayers, and Peter A. Crooks, Exp. Opin. Ther. Patents, 2000, 10,
1561-1581 [36 citations].
218.
"Cooperative Effects of Functional Groups in Ester Hydrolysis: Competitive Inhibitory Effect
of External Nucleophile Concentration on Intramolecular O- to N-Acylation in OAcetylsalicylamide". By Anwar A. Hussain, Janan Jona, and Peter A. Crooks, AAPS Pharm.
Sci. Tech., 2000, 1(3), Article 25.
219.
"Lobeline Inhibits Nicotine-Evoked [3H]Dopamine Overflow from Rat Striatal Slices and
Nicotine-Evoked 86Rb+ Efflux from Thalamic Synaptosomes". By Dennis K. Miller, Peter A.
Crooks, and Linda P. Dwoskin, Neuropharmacology, 2000, 39, 2654-2662 [27 citations].
220.
"Aminoanthroquinones as Novel Ligands on the Polyamine Binding Site of the N-methyl-DAspartate Receptor Complex". By Aimee K. Bence, Dennis T. Rogers, David R. Worthen,
May Fu, John M. Littleton, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters,
2000, 10, 2621-2623.
221.
“Lobeline Noncompetitively Inhibits Methamphetamine Self-administration in Rats”. By
Steven B. Harrod, Jennifer E. Klebaur, Peter A. Crooks, Linda P. Dwoskin, and Michael T.
Bardo, Drug and Alcohol Dependence , 2000, 60, (Supplement), 85-86.
222.
"Effects of Lobeline on Methamphetamine and Nicotine-Induced Hyperactivity and
Sensitization". By Dennis K. Miller, Thomas A. Green, Steven B. Harrod, Michael T. Bardo,
Peter A. Crooks, and Linda P. Dwoskin, Drug and Alcohol Dependence, 2000, 60,
(Supplement), 151-152.
223.
“Conformationally Restrained Analogues of NONI and NDNI are Selective Antagonists at the
Putative 3 2 Nicotinic Acetylcholine Receptor (AChR) Subtype”. By Peter A. Crooks, Rui Xu,
Vladimir P. Grinevich, Aaron J. Haubner, and Linda P. Dwoskin, Drug and Alcohol
Dependence, 2000, 60, (Supplement), 46-47.
224.
“Rigid Nicotine Analogs Provide Selectivity for 7 Subunit-Containing Neuronal Nicotinic
Acetylcholine Receptors”. Vladimir P. Grinevich, Rui Xu, Peter A. Crooks, Aaron J. Haubner,
Roger Papke, and Linda P. Dwoskin, Drug and Alcohol Dependence, 2000, 60,
(Supplement), 80-81.
225.
"Dapsone Analogs as Potential Polyamine Binding Site Modulaters of the N-Methyl-DAspartate Receptor Complex". By Aimee K. Bence, Dennis T. Rogers, David R. Worthen,
May Fu, John M. Littleton, and Peter A. Crooks, Drug Development Res., 2000, 51, 268-272.
47
226.
"Endogenous Indoles as Novel Polyamine Site Ligands at the N-Methyl-D-aspartate
Receptor Complex". By David R. Worthen, David A. Gibson, Dennis T. Rogers, Aimee K.
Bence, May Fu, John M. Littleton, and Peter A. Crooks, Brain Research, 2001, 890, 343-346.
227.
"Lobeline Inhibits the Neurochemical and Behavioral Effects of Amphetamine". By Dennis K.
Miller, Peter A. Crooks, LiHong Teng, Jeffrey M. Witkin, Patrik Munzar, Steven R. Goldberg,
Jane B. Acri, and Linda P. Dwoskin, J. Pharmacol. Exp. Ther., 2001, 296, 1023-1034 [25
citations].
228.
"Accummulation of Nicotine and its Metabolites in Rat Brain after Intermittent or Continuous
Peripheral Administration of [2'-14C]-Nicotine". By Omar A. Ghosheh, Linda P. Dwoskin,
Dennis K. Miller, and Peter A. Crooks, Drug Metab. Disposit., 2001, 29, 645-651 [53
citations].
229.
"Once Weekly Administration of Nicotine Produces Long-Lasting Locomotor Sensitization in
Rats via a Nicotinic Receptor-mediated Mechanism". By Dennis K. Miller, Lincoln H. Wilkins,
Michael T. Bardo, Peter A. Crooks, and Linda P. Dwoskin, Psychopharmacology, 2001,
156, 469-476 [40 citations].
230.
"Competitive Neuronal Nicotinic Receptor Antagonists: A New Direction for Drug Discovery".
By Linda P. Dwoskin and Peter A. Crooks, J. Pharmacol. Exp. Ther., 2001, 298, 395-402 [75
citations].
231.
“Lobeline Attenuates d-Methamphetamine Self-administration in Rats". By Steven B. Harrod,
Linda P. Dwoskin, Peter A. Crooks, Jennifer E. Klebaur, and Michael T. Bardo, J. Pharmacol.
Exp. Therap., 2001, 298, 172-179 [29 citations].
232.
"Neuronal Nicotinic Acetylcholine Receptor Binding Affinities of Boron-containing Nicotine
Analogues". Rui Xu, Vladimir P. Grinevich, A. Gabriela Deaciuc, Linda P. Dwoskin, and Peter
A. Crooks, Biorg. Med. Chem. Lett., 2001, 11, 1245-1248 [15 citations].
233.
"A Contributory Role for Nornicotine in Nicotine Neuropharmacology: Nornicotine Evokes
[3H]Dopamine Overflow from Rat Nucleus Accumbens Slices". By Thomas A. Green, Peter
A. Crooks, Michael T. Bardo, and Linda P. Dwoskin, Biochem. Pharmacol., 2001, 62, 15971603 [10 citations].
234.
"Nornicotine, a Nicotine metabolite and Tobacco Alkaloid: Desensitization of Nicotinic
Receptor-Stimulated Dopamine Release from Rat Striatum". By Linda P. Dwoskin, LiHong
Teng, and Peter A. Crooks, Europ. J. Pharmacol., 2001, 428, 69-79.
235.
“Nicotinic Acetylcholine Receptor Affinities of Boron-Containing Nicotine Analogs”. By Peter
A. Crooks, Rui Xu, Linda P. Dwoskin, Vladimir P. Grinevich, and A. Gabriela Deaciuc, Drug
and Alcohol Dependence, 2001, 63, (Supplement 1), 35.
236.
“Defunctionalized Structural Analogs of Alpha-Lobeline Inhibit [3H]Dopamine Uptake into Rat
Striatal Synaptosomes”. By Steven B. Harrod, Peter A. Crooks, Marlon D. Jones, and Linda
P. Dwoskin, Drug and Alcohol Dependence, 2001, 63, (Supplement 1), 63.
48
237.
“N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit [3H]Dopamine Uptake into Rat
Striatal Synaptosomes”. By Jun Zhu, Joshua T. Ayers, Omar Ghosheh, Peter A. Crooks,
and Linda P. Dwoskin. Drug and Alcohol Dependence, 2001, 63, (Supplement 1), 177.
238.
“Pharmacological Differences Between Immunoisolated Native Brain and Heterologously
Expressed Rat 42 Nicotinic Receptors”. By Anthony Truong, Xiaolei Xing, John R.
Forsayeth, Linda P. Dwoskin, Peter A. Crooks, and Bruce N. Cohen, Mol. Brain Res., 2001,
96, 68-76.
239.
“A Novel Mechanism and Potential Use for Lobeline as a Treatment for Psychostimulant
Abuse”. By Linda P. Dwoskin and Peter A. Crooks, Invited Review, Biochem. Pharmacol.,
2002, 63, 89-98 [49 citations].
240.
"Synthesis of L-Indospicine." By Aimee K. Bence and Peter A. Crooks, Synth. Commun.,
2002, 32 (13), 2075-2082.
241.
“Total Cotinine in Plasma: A Stable Biomarker for Exposure to Tobacco Smoke in Both
Smokers and Passive Smokers". By Jose de Leon, Francesco Diaz, Thea Rogers, D. Brone,
L. Dinsmore, Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, J. Clin.
Psychopharmacol., 2002, 22(5), 496-501 [19 citations].
242.
“Synthesis of Endo-12-aminotricyclo[6.3.2.02,7]trideca-2(7), 3, 5-triene-12-exo-carboxylic
Acid: A Novel, Conformationally Restricted Phenylalanine Analogue.” By Peter A. Crooks
and Jyothi Matheru, Synth. Comm., 2002, 32(24), 3813-3819.
243.
"The Antiproliferative and Immunotoxic Effects of L-Canavanine and L-Canaline". By Aimee
K. Bence, David R. Worthen, Val R. Adams, and Peter A. Crooks, Anti-Cancer Drugs, 2002,
13, 313-320 [10 citations].
244.
"N-n-Alkylnicotinium Analogs, a Novel Class of Nicotinic Receptor Antagonist: Inhibition of
S(-)-Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices". By
Lincoln H. Wilkins, Jr., Aaron Haubner, Joshua T. Ayers, Peter A. Crooks, and Linda P
Dwoskin, J. Pharmacol. Exp. Therap., 2002, 301, 1088-1096.
245.
"Synthesis and Evaluation of Conformationally Restricted Pyridino N-Alkylated Nicotine
Analogs as Neuronal Nicotinic Acetylcholine Receptor Antagonists". By Rui Xu, Linda P.
Dwoskin, Vladimir P. Grinevich, Aaron Haubner, and Peter A. Crooks, Drug Development
Res., 2002, 55, 173-186 [17 citations].
246.
“Epilepsy - A Review of the Recent Patent Literature”. By Peter A. Crooks, Joshua Ring, and
Aaron Haubner, IDrugs, 2002, 5, 990-999.
247.
“bis-Azaaromatic Quaternary Ammonium Analogues: Ligands for 42* and α7* Subtypes of
Neuronal Nicotinic Receptors". By Joshua T. Ayers, Linda P. Dwoskin, A. Gabriela Deaciuc,
Vladimir P. Grinevich, Jun Zhu, and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2002, 12,
3067-3071 [20 citations].
248.
“Meso-transdiene, a Potent, Selective Antagonist at alpha3*-containing Nicotinic Receptors”.
By Linda P. Dwoskin, Dennis K. Miller, Guangrong Zheng, Seth D. Norrholm, Vladimir P.
Grinevich, and Peter A. Crooks, Drug and Alcohol Dependence, 2002, 64, 38.
49
249.
“8-Hydroxyl Esterification of Lobeline Increases Selectivity for the alpha4beta2* Subtype of
Nicotinic Receptor, While Increasing Affinity for Dopamine and Serotonin Transporters”. By
Seth D. Norrholm, Dennis K. Miller, Marhaba Hojahmat, Peter A. Crooks, and Linda P.
Dwoskin. Drug and Alcohol Dependence, 2002, 64, 25.
250.
“The Bis-picolinium Salt, bPiDDB, is a Potent and Selective Antagonist at Nicotinic
Acetylcholine Receptors Mediating Nicotine-evoked Dopamine Release in Rat Striatum”. By
Peter A. Crooks, Joshua T. Ayers, Aaron J. Haubner, Vladimir P. Grinevich, Sangeetha P.
Sumithran, A. Gabriela Deaciuc and Linda P. Dwoskin. Drug and Alcohol Dependence,
2002, 64, 38.
251.
“L-Canavanine as a Radiosensitization Agent for Human Pancreatic Cancer Cells.” By Aimee
K. Bence, Val R. Adams, and Peter A. Crooks, Mol. Cell. Biochem., 2003, 244, 37-43.
252.
"Plasma Cotinine, 3’-Hydroxycotinine and their Glucuronides in Caucasian and African
American Smokers”. By Jose de Leon, Francisco J. Diaz, Thea Rogers, Debra Browne, Lori
Dinsmore, Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, J. Clin.
Psychopharmacol., 2003, 23(2), 209-211.
253. "A Pilot Study of Plasma Caffeine Concentrations in a U.S. Sample of Smokers and
Nonsmokers". By Jose de Leon, Francisco Diaz, Thea Rogers, Debra Browne, Lori
Dinsmore, Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, Progress in NeuroPsychopharmacology & Biological Psychiatry, 2003, 27, 165-171 [33 citations].
254.
"N-n-Alkylnicotinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Interaction
with 42* and 7* Neuronal Nicotinic Receptors". By Lincoln H. Wilkins, Peter A. Crooks,
and Linda P. Dwoskin, J. Pharmacol. Exp. Therap., 2003, 304, 400-410 [23 citations].
255.
"Drug Targeting to the Lung: Chemical and Biochemical Considerations". By Peter A.
Crooks and Abeer M. Al-Ghananeem, Invited Chapter in "Pharmaceutical Inhalation Aerosol
Technology. Second Edition", Edit. Anthony Hickey, Marcel Dekker, Inc., NY, Chapter 4, pp
89-154, 2003.
256.
“N,N-Disubstituted Piperazines: Synthesis and Affinities at 42* and 7* Neuronal Nicotinic
Acetylcholine Receptors”. By Jianhong Chen, Seth Norrholm, Linda P. Dwoskin, Peter A.
Crooks, and Donglu Bai, Bioorganic and Medicinal Chemistry Letters, 2003, 13, 97-100.
257.
“Active Transport of High Affinity Choline and Nicotine Analogs into the Central Nervous
System by the Blood-Brain Barrier Choline Transporter”. By David D. Allen, Paul R.
Lockman, Karen E. Roder, Linda P. Dwoskin, and Peter A. Crooks, J. Pharmacol. Exp.
Therap., 2003, 304, 1268-1274 [18 citations].
258.
“An In Vivo Evaluation of the Antiseizure Activity and Acute Neurotoxicity of Agmatine.” By
Aimee K. Bence, David R. Worthen, James P. Stables and Peter A. Crooks, Pharmacol.
Biochem. Behav., 2003, 74, 771-775 [15 citations.
259.
“The Mechanism of L-Canavanine Cytotoxicity: Arginyl-tRNA Synthetase as a Novel Target
for Anticancer Drug Discovery.” By Aimee K. Bence and Peter A. Crooks, J. Enz. Inhibit.
Med. Chem., 2003, 18, 383-394.
260.
“N-n-Alkylpyridinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Selective
Inhibition of Nicotine-Evoked [3H]Dopamine Overflow from Rat Striatal Slices.” By Vladimir P.
50
Grinevich, Peter A. Crooks, Aaron J. Haubner, Omar A. Ghosheh, Joshua T. Ayers, and
Linda P. Dwoskin, J. Pharmacol. Exp. Ther., 2003, 306, 1011-1020.
261.
“An Improved Synthesis of -Nicotyrine from the Dehydrogenation of Nicotine: Comparison
of Conventional and Microwave-Assisted Reactions.” By Xiaochen Wei and Peter A. Crooks,
Synthetic Communications, 2003, 33(19), 3305-3315.
262.
“NADPH Oxidase Activity is Essential for Keap1-Nrf2-Mediated Induction of GCLC in
Response to 2-Indole-3-yl-methylenequinuclidin-3-ols”. By Konjeti R. Sekhar, Peter A.
Crooks, Vijayakumar N. Sonar, David B. Friedman, Jeff Y. Chan, Michael J. Meredith,
Joseph H. Starnes, Kathy R. Kelton, Samantha R. Summar, Soumya Sasi, and Michael
Freeman, Cancer Research, 2003, 63, 5636-5645 [23 citations].
263.
“2-(1-Benzyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one”.
By
Vijayakumar
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o1478o1480.
264.
“Spectroscopic and Steady-State Kinetic Analysis of the Biosynthetic Arginine Decarboxylase
of Yersinia Pestis Utilizing Arginine Analogs as Inhibitors and Alternate Substrates”. By Paul
B. Balbo, Chandra N. Patel, R. Scott Adcock, Sundar Neelakantan, Peter A. Crooks, and
Marcos A.. Oliveira, Biochemistry, 2003, 42, 15189-15196.
265.
"N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit Dopamine Transporter
Function: Selectivity as Nicotinic Receptor Antagonists". By Jun Zhu, Peter A. Crooks,
Joshua T. Ayers, Sangitha P. Sumithran, and Linda P. Dwoskin, Drug Development Res.,
2003, 60, 270-284.
266.
“(Z)-2-Thiophen-3-ylmethylene-1-aza-bicyclo[2.2.2]octan-3-one”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o1464-o1466.
267.
“(Z)-2-(3-Hydroxy-4-methoxybenzylidene)-1-aza-bicyclo[2.2.2]octane-3-one”. By Vijayakumar N.
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2003, C59, o647-o649.
268.
“(Z)-2-Benzo[b]thiophen-3-ylmethylene-1-aza-bicyclo[2.2.2]-octan-3-one”. By Vijayakumar N.
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o1726o1728.
269.
“(Z)-2-(2,4-Dimethoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-ol”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o2010-o2012.
270.
“The Preparation of 2-Arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octane-3-ones”. By
Guangrong Zheng, Linda P. Dwoskin, and Peter A. Crooks, Synth. Comm., 2004, 34(11),
1931-1942.
271.
“Toxicity of Dipyridyl Compounds”. By Shenggang Li, Peter A. Crooks, Xiaochen Wei, and
Jose de Leon, Crit. Rev. Tox., 2004, 34, 447-460.
272.
“Subtype-Selective Nicotinic Receptor Antagonists: Potential as Tobacco Use Cessation
Agents”. By Linda P. Dwoskin, Sangeetha Sumithran, Jun Zhu, A. Gabriela Deaciuc, Joshua
T. Ayers and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2004, 14, 1863-1867 [21 citations].
51
273.
“Development of Subtype-Selective Ligands as Antagonists at Nicotinic Receptors Mediating
Nicotine-Evoked Dopamine Release”. By Peter A. Crooks, Joshua T. Ayers, Xu Rui,
Sangeetha P. Sumithran, Vladimir P. Grinevich, Lincoln Wilkins, A. Gabriela Deaciuc, David
D. Allen and Linda P. Dwoskin, Bioorg. Med. Chem. Lett., 2004, 14, 1869-1874 [20 citations].
274.
“(Z)-2-(1H-Indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2004, C60, o6-o8.
275.
“Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octane-3-ol”. By Guangrong Zheng, Sean
Parkin, Linda P. Dwoskin, and Peter A. Crooks, Acta Crystallogr., Section C, 2004, C60, o9o11.
276.
“Elimination of Alkaloids from Plant-Derived Human Monoclonal Antibody”. Kisung Ko,
Xiaochen Wei, Peter A. Crooks, Hilary Koprowski, Journal of Immunological Methods, 2004,
286, 79-85.
277.
“2-(1-Methyl-1H-indol-3ylmethylene)-1-aza-bicyclo[2.2.2]octane-3-one: Acid-Catalyzed
Isomerization of the Z isomer to the E isomer”. By Vijayakumar N. Sonar, Sean Parkin, and
Peter A. Crooks, J. Chem. Crystallogr., 2004, 34, 239-244.
278.
“Molecular Pathway for Thymoquinone-Induced Cell Cycle Arrest and Apoptosis in
Neoplastic Keratinocytes”. By Hala U. Gali-Muhtasib, Wassim G. Abou Kheir, Lynn A. Kheir,
and Peter A. Crooks, Anticancer Drugs, 2004, 15(40), 389-399 [16 citations].
279.
“(Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2004, C60, o217-o218.
280.
“A Duplex “Gemini” Prodrug of Naltrexone for Transdermal Delivery”. By Dana C. Hammell,
Mohamed O. Hamad, H. Kumar Vaddi, Peter A. Crooks, and Audra L. Stinchcomb, J.
Controlled Release, 2004, 97, 283-290.
281.
“Physicochemical Evaluation, In Vitro Human Skin Diffusion and Concurrent
Biotransformation of O-3-Alkylcarbonate Prodrugs of Naltrexone”. By Omathanu Pillai,
Mohamed O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb. Pharm. Research, 2004,
21, 1146-1152 [11 citations].
282.
“Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular
Monoamine Transporters and Diminished Activity at 42 and 7 nAChRs”. By Dennis K.
Miller, Peter A. Crooks, Guangrong Zheng, Vladimir P. Grinevich, Seth Norrholm, and Linda
P. Dwoskin, J. Pharmacol. Exper. Therap., 2004, 310, 1035-1045 [17 citations].
283.
"1-(2, 5-Dichloro-phenyl)-3-methyl-5-phenyl-1H-pyrazole". By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2004, C60, o547-o549.
284.
"(E)-N-Benzo[b]thiophen-3-ylmethylene-N-(2, 5-dichloro-phenyl) hydrazine". By Vijayakumar
N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2004, C60, o550o551,
285.
“(Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one and
(±)-(Z)-2-(1-Phenylsulfonyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-ol”. By
Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C,
52
2004, C60, o659-o661 [24 citations].
286.
“4-Benzo[b]thiophen-3-yl-1-methyl-piperidine-4-carbonitrile”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2004, E60, o1533-o1534.
287.
“Indirect Trapping of the Retro-Conjugate Addition Reaction Intermediate Involved in Lobeline
Epimerization: Application to the Synthesis of (-)-Sedamine”. By Guangrong Zheng, Linda P.
Dwoskin, and Peter A. Crooks, J. Org. Chem., 2004, 69, 8514-8517.
288.
“(Z)-3-(1H-Indol-3-yl)-2-thiophen-3-yl-acrylonitrile and (Z)-3-[1-(4-tert-Butyl-benzyl)-1H-indol3-yl]-2-thiophen-3-yl-acrylonitrile”. By Vijayakumar N. Sonar, Sean Parkin, and Peter A.
Crooks, Acta Crystallogr., Section C, 2005, C61, o78-o80.
289.
“In Vivo Evaluation of 3-O-Alkyl Ester Transdermal Prodrugs of Naltrexone in Hairless
Guinea Pigs”. By Satyanarayana Valiveti, Dana C. Hammell, Kalpana S. Paudel, Mohamed
O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb, J. Controlled Release, 2005, 102,
509-520.
290.
“Bioconversion of Naltrexone and Its 3-O-Alkyl Ester Prodrugs in a Human Skin Equivalent”.
By Dana C. Hammell, Elzbieta I. Stolarczyk, Mitch Klausner, Mohamed O. Hamad, Peter A.
Crooks, and Audra L. Stinchcomb, J. Pharm. Sci., 2005, 94, 828-826.
291.
“(Z)-2-Thiophen-3-yl-3-(3, 4, 5-trimethoxy-phenyl)acrylonitrile”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2005, E61, o933-o935.
292.
“Introduction of Unsaturation into the N-n-Alkyl Chain of the Neuronal Nicotinic Receptor
Antagonists, NONI and NDNI: Effect on Affinity and Selectivity”. By Sangeetha P. Sumithran,
Peter A. Crooks, Rui Xu, Jun Zhu, Agripina G. Deaciuc, Lincoln H. Wilkins, and Linda P.
Dwoskin, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction:
From Basic Research to Therapeutics, 2005, 7(1). E201-217.
293.
“Molecular Modeling of Mono- and Bis-Quaternary Ammonium Salts as Ligands at the α4β2*
Nicotinic Acetylcholine Receptor Subtype Using Non-Linear Techniques”. By Joshua T.
Ayers, Aaron Clauser, Jeffrey D. Schmitt, Linda P. Dwoskin and Peter A. Crooks, AAPS
Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction: From Basic
Research to Therapeutics, 2005, 7(3), E678-E685.
294.
“Human Skin Permeation of Branched Chain 3-O-Alkyl Ester and Carbonate Prodrugs
of Naltrexone”. By Haranath K. Vaddi, Mohamed O. Hamad, Jianhong Chen, Stan L.
Banks, Peter A. Crooks, and Audra L. Stinchcomb, Pharm. Research, 2005, 22, 758765.
295.
“In Vitro Release Studies on Matrix Type Transdermal Drug Delivery Systems of Naltrexone
and its Acetyl Prodrug”. By Buchi N. Nalluri, Caitlin Milligan, Jianhong Chen, Peter A.
Crooks, and Audra L. Stinchcomb, Drug Development and Industrial Pharmacy, 2005, 31,
871-877.
296.
“3D-QSAR Study of bis-Azaaromatic Quaternary Ammonium Analogs at the Blood-Brain
Barrier Choline Transporter”. By Werner J. Geldenhuys, Paul R. Lockman, Tiffany H.
Nguyen, Cornelis J. Van der Schyf, Peter A. Crooks, Linda P. Dwoskin, and David D. Allen,
Biorg. Med. Chem., 2005, 13, 4253-4261.
53
297.
“In Vitro/In Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs”.
By Satyanarayana Valiveti, Kalpana S. Paudel, Dana C. Hammell, Mohamed O. Hamad,
Jianhong Chen, Peter A. Crooks, and Audra L. Stinchcomb, Pharm. Research., 2005, 22,
981-989 [10 citations].
298.
“A General Procedure for the Enantioselective Synthesis of the CNS-active Minor Tobacco
Alkaloids: Nornicotine, Anabasine and Anatabine”. By Joshua T. Ayers, Rui Xu, Linda P.
Dwoskin, and Peter A. Crooks, AAPS Journal: AAPS-NIDA Symposium, Frontiers in
Science: Drug Addiction: From Basic Research to Therapeutics, 2005, 7(3), E752-E758.
299.
“Lobeline Analogues as Novel Ligands for the Vesicular Monoamine Transporter”. By
Guangrong Zheng, Linda P. Dwoskin, Agripina G. Deaciuc, Seth D. Norholm, Marlon D.
Jones, and Peter A. Crooks, Bioorganic Med. Chem., 2005, 13, 3899-3909.
300.
“Evaluation of O3-, O21-DI-(N1-Methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl)17hydroxy-5-pregnan-20-one as a Novel Potential Antiangiogenic Codrug”. By Michelle
Howard-Sparks, Abeer M. Al-Ghananeem, Andrew P. Pearson, and Peter A. Crooks, J.
Enzyme Inhibit. Med. Chem., 2005, 20, 417-428.
301.
“Defunctionalized Lobeline Analogues: Structure-Activity of Novel Ligands for the Vesicular
Monoamine Transporter”. By Guangrong Zheng, Linda P. Dwoskin, A. Gabriela Deaciuc,
Seth D. Norrholm, and Peter A. Crooks, J. Medicin. Chem., 2005, 48, 5551-5560.
302.
"Transdermal Delivery of Naltrexone and its Active Metabolite 6-beta-Naltrexol in Human
Skin In Vitro and Guinea Pigs In Vivo". By Kalpana S. Paudel, Nalluri B Naidu, Paul Kiptoo,
Dana Hammell, Mohamed O. Hamad, Satyanarayana Valiveti, Peter A. Crooks, and Audra L.
Stinchcomb, J. Pharm. Sci., 2005, 94, 1965-1975.
303.
“Novel Antiglaucoma Prodrugs and Codrugs of Ethacrynic Acid”. By Grazyna Cynkowska,
Tadeusz Cynkowski, Abeer A. Al-Ghananeem, Hong Guo, Paul Ashton, and Peter A.
Crooks, Bioorg. Med. Chem. Lett., 2005, 15, 3524-3527 [10 citations].
304.
“The Characterization of a Novel α7-selective nAChR Agonist and the Modulation of Agonist
Properties by Boron Inclusion”. By Roger L. Papke, Linda Dwoskin, Nicole A. Horenstein,
and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2005, 15, 3874-3880.
305.
“N-(2, 5-Dichlorophenyl)-N’-[(E)-3-thienyl-methylene]hydrazine”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2005, E61, 01907-o1909.
306.
“Modeling Multiple Species of Nicotine and Deschloroepibatidine Interacting with α4β2
Nicotinic Acetylcholine Receptors: From Microscopic binding to Phenomenological Binding
Affinity”. By Xiaoqin Huang, Fang Zheng, Peter A. Crooks, Linda P. Dwoskin and ChangGuo Zhan, J. Amer. Chem. Soc., 2005, 127, 14401-14414 [16 citations].
307.
“6-Acetoxy-4, 5-epoxy-3-methoxy-17-methyl-morphin-7-ene”.
308.
“(E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-Methyl-2-nitrovinyl)-2-phenyl1H-indole”. By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr.,
Section C, 2005, C61, o527-o530.
By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2005, E61, o2579-2581.
54
309.
“A 1R, 2R, 5R-(+)-2α-hydroxypinan-3-one Ketimine”. By Joshua T. Ayers, Vijayakumar N.
Sonar, Sean Parkin, Linda P. Dwoskin, and Peter A. Crooks, Acta Crystallogr., Section E,
2005, E61, o2682-o2684.
310.
“Synthesis and Evaluation of a Series of Tropane Analogues as Novel Vesicular Monoamine
Transporter-2 Ligands”. By Guangrong Zheng, Linda P. Dwoskin, Agripina G. Deaciuc, and
Peter A. Crooks, Bioorg. Med. Chem. Lett., 2005, 15, 4463-4466.
311.
“Identification and Synthesis of Novel Alkaloids from the Root System of Nicotiana tabacum:
Affinity for Neuronal Nicotinic Acetylcholine Receptors". By Xiaochen Wei, Sangeetha P.
Sumithran, A. Gabriela Deaciuc, Harold R. Burton, Lowell P. Bush, Linda P. Dwoskin and
Peter A. Crooks, Life Sciences: Special Issue, National Institutes of Health (NIDA)
Symposium on Naturceuticals and Nutraceuticals, 2005, 78, 495-505.
312.
“(Z)-2-(3-Methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2005, C61, o660-o661.
313.
“(Z)-2-(3-Nitro-benzylidene)-1-azabicyclo[2.2.2]octan-3-one”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2005, E61, o3254-o3256.
314.
“(2E, 4E)-8-Methyl-2, 4-bis-thiophen-3-ylmethylene-8-azabicyclo[3.2.1]octan-3-one”. By
Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E,
2005, E61, o3445-o3446.
315.
“Effect of a Novel Nicotinic Receptor Antagonist, N,N’-dodecane-1,12-diyl-bis-picolinium
dibromide (bPiDDB), on Nicotine Self-Administration and Hyperactivity in Rats”. By Nicole M.
Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin and Michael T. Bardo,
Psychopharmacology, 2006, 184, 426-434 [16 citations].
316.
"N-Alkylnicotinium Analogs, a Novel Class of Antagonists at α4β2* Nicotinic Acetylcholine
Receptors: Inhibition of Nicotine-Evoked 86Rb+ Efflux from Rat Thalamic Synaptosomes".
By Lincoln H. Wilkins, Jr., Dennis K. Miller, Joshua T. Ayers, Peter A. Crooks, and Linda P.
Dwoskin, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction:
From Basic Research to Therapeutics, 2006, 7(4), Article 90, E922-E930.
317.
“QSAR Modeling of mono- and bis-Quaternary Ammonium Salts that Act as Antagonists at
Neuronal Nicotinic Acetylcholine Receptors Mediating Dopamine Release”. By Fang Zheng,
Ersin Bayram, Sangeetha P. Sumithran, Joshua T. Ayers, Chang-Guo Zhan, Jeffrey D.
Schmitt, Linda P. Dwoskin, and Peter A. Crooks, Bioorganic Medicinal Chem., 2006, 14,
3017-3037.
318.
“Synthesis and Stability of Two Indomethacin Prodrugs”. By Shyamala Chandrasekaran,
Abeer M. Al-Ghananeem, Robert M. Riggs, and Peter A. Crooks, Biorg. Med. Chem. Lett.,
2006, 16, 1874-1879.
319.
“(Z)-2-(2-Methoxy-benzylidene)-1-azabicyclo[2.2.2]octan-3-one”.
By
Vijayakumar
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62,
o393-o395.
55
N.
320.
“(Z)-2-(4-Methoxy-benzylidene)-1-azabicyclo[2.2.2]octan-3-one”.
By
Vijayakumar
N.
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62,
o396-o397.
321.
“Oxycodone via Sublingual Spray for Acute Pain Management”. By Abeer M. Al-Ghananeem,
Ahmad Malkawi, and Peter A. Crooks, AAPS Journal, 2006, 7(1), Article 23.
322. “(Z)-2-[1-(4-Methylbenzenesulfonyl)-1H-indol-3-ylmethylene]-1- azabicyclo[2.2.2]octan-3one” By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr.
Section E, 2006, E62, o623-o625.
323. “1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)-formamide”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2006, C62, o153-o154.
324. “Methyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate”. By Vijayakumar N. Sonar, Sean Parkin,
and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o1077-o1078.
325.
“N, N-Disubstituted Piperazines and Homopiperazines: Synthesis and Affinities at 42*
and 7* Neuronal Nicotinic Acetylcholine Receptors”. By Jianhong Chen, Agripina G.
Deaciuc, Linda P. Dwoskin, Donglu Bai and Peter A. Crooks, J. Enz. Inhibit. Med. Chem.,
2006, 21(6), 667-680.
326. “Enhancement of Transdermal Delivery of 6--Naltrexol via a Codrug Linked to
Hydroxybupropion”. By Paul K. Kiptoo, Mohamed, O. Hamad, Peter A. Crooks, and
Audra L. Stinchcomb, J. Controlled Release, 2006, 113, 137-145 [12 citations].
327. “Opiate Receptor Binding Properties of Morphine-, Dihydromorphine-, and Codeine-6-OSulfate Ester Congeners”. By Peter A. Crooks, Santosh Kottayil, Abeer M. AlGhananeem, Stephen R. Byrn, and D. Alan Butterfield, Bioorg. Med. Chem. Lett.,
2006, 16, 4291-4295.
328. “Synthesis and Hydrolytic Behavior of Two Novel Tripartate Codrugs of Naltrexone and
6β-Naltrexol with Hydroxybupropion as Potential Alcohol Abuse and Smoking Cessation
Agents”. By Mohamed O. Hamad, Paul K. Kiptoo, Audra L. Stinchcomb, Peter A. Crooks,
Bioorg. Med. Chem., 2006, 14, 7051-7061.
329. “1-(4-Methoxybenzyl)-1H-indole-3-carbaldehyde”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3231-o3232.
330. “Vesicular Monoamine Transporter 2: Role as a Drug Target for Ligand Development”. By
Guangrong Zheng, Linda P. Dwoskin, and Peter A. Crooks, AAPS Journal: NIDA -AAPS
Symposium on Drugs of Abuse: Mechanisms of Toxicity, Toxicokinetics and Medical
Consequences of Drugs of Abuse", 2006, 8(4), Article 78, E682-E692.
331.
“(E)-1-Benzyl-3-(2-nitrovinyl)-1H-indole”. By Vijayakumar N. Sonar, Sean Parkin, and
Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3328-o3330.
332.
“1-(4-tert-Butylbenzyl)-1H-indole-3-carbaldehyde”. By Vijayakumar N. Sonar, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3380-o3381.
333.
“Des-keto Lobeline Analogs with Increased Potency and Selectivity at Dopamine and
56
Serotonin Transporters”. By Guangrong Zheng, David Horton, Agripina G. Deaciuc,
Linda P. Dwoskin, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters,
2006, 16, 5018-5021.
334.
“(Z)-2-Thiophen-2-ylmethylene-1-azabicyclo[2.2.2]octan-3-one”. By
Vijayakumar N. Sonar, M. Venkatraj, Sean Parkin, and Peter A. Crooks, Acta
Crystallogr., Section E, 2006, E62, o5869-o5870.
335.
“1-Azepan-1-yl-2-(1H-indol-3-yl)ethane-1,2-dione”. By Vijayakumar N. Sonar,
Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62,
o3744-o3746.
336.
“Assessment of Nasal Drug Delivery in Humans Using Radionuclide Imaging Techniques”.
By Abeer M. Al-Ghananeem and Peter A. Crooks, Pharmaceutical Formulation and
Quality, 2006, 8(4), 38-43.
337.
“Translation in Tobacco and Drug Abuse Prevention Research”, By M. A. Pentz, Zhenfa
Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Eval. Health Prof.,
2006, 29, 246-271.
338.
“(Z)-2-(Cyclohexylidene)-1-azabicyclo[2.2.2]octan-3-one”. By Vijayakumar N.
Sonar, M. Venakataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr.,
Section E, 2006, E62, o5576-5577.
339.
“Nornicotine Inhibition of Dopamine Transporter Function in Striatum via Nicotinic
Receptor Activation”. By Lisa S. Middleton, Peter A. Crooks, Peter J. Wedlund, Wayne
A. Cass, and Linda P. Dwoskin, Synapse, 2006, 61(3), 157-165.
340. “(Z)-2-(1, 3-Benzodioxol-5-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one”. By
Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta
Crystallogr., Section E, 2006, E62, o5742-o5744.
341. “(Z)-2-(2-Methylbenzylidene)-1-azabicyclo[2.2.2]octan-3-one”. By
Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta
Crystallogr., Section E, 2006, E62, o5738-o5739.
342.
“Modeling Subtype-Selective Agonists Binding with α4β2 and α7 Nicotinic Acetylcholine
Receptors: Effects of Local Binding and Long-Range Electrostatic Interactions”. By
Xiaoqin Huang, Xi Chen, Fang Zheng, Peter A. Crooks, Linda P. Dwoskin, and Chang
Guo Zhan, J. Medicin. Chem., 2006, 49, 7661-7674 [12 citations].
343. “(Z)-2-(4-Methylbenzylidene)-1-azabicyclo[2.2.2]octan-3-one”. By
Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta
Crystallogr., Section E, 2006, E62, o5740-o5741.
344.
“Effects on Nornicotine Enantiomers on Intravenous S(-)-Nicotine Self-Administration
and Cardiovascular Function in Rats”. By Dustin J. Stairs, Nicole M. Neugebauer,
Xiaochen Wei, C. Boustany, Marhaba Hojahmet, Lisa A. Cassis, Peter A. Crooks, and
Linda P. Dwoskin, Michael T. Bardo, Psychopharmacology, 2007, 190, 145-155.
345.
“Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization
57
Through a Mitotic Catastrophe Pathway”. By Konjeti R Sekhar, Vijayakumar N. Sonar,
Venkatraj Muthusamy, Soumya Sasi, Andrei Laszlo, Jamil Swani, Nobuo Horikoshi,
Ryji Higashikubo, Robert G. Bristow, Michael J. Borrelli, Peter A. Crooks, James R.
Lepock, Joseph L. Roti Roti, and Michael L. Freeman, Cancer Res., 2007, 67, 695-701.
346.
“Scopolamine Sublingual Spray: An Alternative Route of Delivery for the Treatment of
Motion Sickness”. By Abeer Al-Ghananeem, Ahmad H. Malkawi, and Peter A. Crooks,
Drug Development and Industrial Pharmacy, 2007, 33, 577-582.
347.
“A Novel Chemical Delivery System Comprising an Ocular Sustained Release
Formulation of 3α, 17α, 21-Trihydroxy-5-pregnan-20-one-BIS-5-fluorouracil Codrug.
By Michelle Howard-Sparks, Abeer M. Al-Ghananeem, Andrew P. Pearson, and Peter
A. Crooks, Drug Development and Industrial Pharmacy, 2007, 33, 677-682.
348.
“The Effects of a Novel Nicotinic Receptor Antagonist N, N-Dodecane-1, 12-diyl-bispicolinium dibromide (bPiDDB) on Acute and Repeated Nicotine-induced Increases in
Extracellular Dopamine in Rat Nucleus Accumbens”. By Shafiq Rahman, Nicole M.
Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo,
Neuropharmacology, 2007, 52, 755-763 [13 citations].
349.
“Tablet Formulation Studies on Nimesulide- and Meloxican-Cyclodextrin Binary
Systems”. Buchi N. Nalluri, K. P. R. Chowdary, K. V. R. Murthy, G. Becket, and Peter A
Crooks, AAPS PharmSciTech, 2007, 8(2), Article 36, E1-E7.
350.
“A Pharmacokinetic Study on 3-(N-Benzylindole-3-yl)methylenequinuclidin-3-ol; a Novel
Radiosensitization Agent”. By Abeer M. Al-Ghananeem, Zaineb Al-Beyati, Ahmad
Malkawi, Vijayakumar Sonar, and Peter A. Crooks, Cancer Chemother. Pharmacol.,
2007, 60, 915-919.
351.
“(Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one”.
By Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C,
2007, C63, o135-o136.
352.
“The Pharmacological Activity of Nicotine and Nornicotine on nAChR Subtypes:
Relevance to Nicotine Dependence and Drug Discovery”. By Roger L. Papke, Linda P.
Dwoskin, and Peter A. Crooks, J. Neurochemistry, 2007, 101, 160-167.
353. “(E)-1-(2-Methoxyphenyl)methyleneaminoguanidine monohydrochloride. By Vejayakumar
N. Sonar, Sundar Neelakantan, Maxime Siegler and Peter A. Crooks, Acta Crystallogr.,
Series E, 2007, E63, o535-536.
354. “Computational Neural Network Analysis of the Affinity of Lobeline and Tetrabenazine
Analogs for the Vesicular Monoamine Transporter-2”. By Fang Zheng, Guangrong
Zheng, A. Gabriela Deaciuc, Chang-Guo Zhan, Linda P. Dwoskin and Peter A. Crooks,
Bioorg. Med. Chem., 2007, 15, 2975-2992.
355.
“(E)-1-(2-Chlorophenyl)methyleneaminoguanidine hydrochloride”. By Vijayakumar N.
Sonar, Joshua R. Ring, Maxime Siegler and Peter A. Crooks, Acta Crystallogr., Section E,
2007, E63, o974-o975.
356.
“Rac-(Z)-2-Thiophen-2-ylmethylene-1-azabicyclo[2.2.2]octan-3-ol”. By
58
Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta
Crystallogr., Section C, 2007, C63, o493-o495.
357.
“(Z)-2-[(Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one
Semicarbazone”. By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A.
Crooks, Acta Crystallogr., Section C, 2007, C63, o277-o279.
358.
“Supression of Pancreatic Tumor Growth by Combination Therapy with Sulindac and
LC-1 is Associated with Cyclin D1 Inhibition In Vivo”. By Michele T. Yip-Schneider,
Huangbing Wu, Matthew Ralstin, Constantin Yiannoutsos, Peter A. Crooks, Sundar
Neelakantan, Steven Noble, Harikrishna Nakshatri, Christopher J. Sweeney, and C.
Max Schmidt, Mol. Cancer Therapeutics, 2007, 6(6):1736-1744.
359.
“Phase I and Phase II Ocular Metabolic Activities and the Role of Metabolism in
Ophthalmic Prodrug and Codrug Design and Delivery”. By Abeer M. Al-Ghananeem and
Peter A. Crooks, Molecules, 2007, 12, 373-388.
360.
“(4-Methoxy-3-nitrobenzylidenamino)guanidine Hydrochloride”. By Joshua R. Ring,
Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o392-o394.
361.
“Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer”. By Reid
C. Vegeler, Michele T. Yip-Schneider, Matthew Ralstin, Huangbing Wu, Peter A. Crooks,
Sundar Neelakantan, Harikrishna Nakshatri, Christopher J. Sweeney, and C. Max
Schmidt, Journal of Surgical Research, 2007, 143, 169-176.
362.
“Benzyl 2, 6-Dihydroxy-3-nitrobenzoate”. By Vijayakumar N. Sonar, M.
Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E,
2007, E63, o3226.
363.
“Methyl 2, 6-dihydroxy-3-nitrobenzoate”. By Vijayakumar N. Sonar, M.
Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E,
2007, E63, o3227.
364.
“Discovery of a Novel Nicotinic Receptor Antagonist for the Treatment of
Nicotine Addiction: 1-(3-methylpyridinium)-12-triethylammonium-dodecane
Dibromide (TMPD)”. By Linda P. Dwoskin, Barry M. Joyce, Guangrong Zheng,
Nichole M. Neugebauer, Vamshi K. Manda, Paul Lockman, Roger L. Papke,
Michael T. Bardo, and Peter A. Crooks, Biochemical Pharmacology, 2007, 74,
1271-1282.
365.
“An HPLC Method for the Simultaneous Determination of Neurotoxic Dipyridyl
Isomers in Human Plasma”. By Ahmad Malkawi, Abeer Al-Ghananeem,
Shama Naseem, Xiaochen Wei, Jose de Leon, and Peter A. Crooks, J.
Pharm. Biomed. Anal., 2007, 45, 120-124.
366.
"Lobelane Decreases Methamphetamine Self-administration in Rats”. By Nicole M.
Neugebauer, Steven B. Harrod, Dustin J. Stairs, Peter A. Crooks, Linda P. Dwoskin,
and Michael T. Bardo, European Journal of Pharmacology, 2007, 571, 33-38.
367.
“The Radiosensitization Effect of Parthenolide in Prostate Cancer Cells is Mediated by
NF-кB Inhibition and Enhanced by the Presence of PTEN”. By Yulan Sun, Daret K. St.
59
Clair, Fang Fang, Graham W. Warren, Vivek M. Rangnekar, Peter A. Crooks, and
William H. St. Clair, Molecular Cancer Therapeutics, 2007, 6(9), 2477-2486.
368.
“An Orally Biovailable Parthenolide Analog Selectively Eradicates Acute Myelogenous
Leukemia Stem Cells and Progenitor Cells”. By Monica L. Guzman, Randall M. Rossi,
Sundar Neelakantan, Xiaojie Li, Cheryl Corbett, Duane C. Hassane, Michael W. Becker,
John M. Bennet, Edmund Sullivan, Joshua L. Lachowicz, Christopher Sweeney, William
Matthews, Martin Carroll, Peter A. Crooks, and Craig T. Jordan, Blood, 2007, 110, 44274435 [15 citations].
369.
“rac-(Z)-2-(2,4-Dichlorobenzylidene)-1-azabicyclo[2.2.2]octan-3-ol”. By Vijayakumar N.
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63,
o3907,
370.
“rac-(Z)-2-(Naphthalen-1-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol”. By Vijayakumar N.
Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63,
o3915,
371.
“(11R)-13-(Benzylamino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim, Sean
Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3922.
372.
“(Z)-3-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile”. Vijayakumar N. Sonar,
Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3979.
373.
“bis-Azaaromatic Quaternary Ammonium Salts as Antagonists at Nicotinic Receptors
Mediating Nicotine-Evoked Dopamine Release: An Investigation of Binding Conformation”.
By Guangrong Zheng, Zhenfa Zhang, Marharyta Pivavarchyk, Agripina G. Deaciuc, Linda
P. Dwoskin and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2007, 17,
6734-6738.
374.
“tris-Azaaromatic Quaternary Ammonium Salts: Novel Templates as Antagonists at
Nicotinic Receptors Mediating Nicotine-Evoked Dopamine Release”. By Guangrong
Zheng, Sangeetha P. Sumithran, Agripina G. Deaciuc, Linda P. Dwoskin and Peter A.
Crooks, Bioorganic and Medicinal Chemistry Letters, 2007, 17, 6701-6706.
375.
“Novel substituted (Z)-2-(N-Benzylindol-3-ylmethylene)quinuclidin-3-one & (Z)-(±)-2-(NBenzylindol-3-ylmethylene)quinuclidin-3-ol Derivatives as Potent Thermal Sensitizing
Agents”. By Vijayakumar N. Sonar, Y. Thirupathi Reddy, Konjeti R. Sekhar, Soumya Sasi,
Michael L. Freeman, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters,
2007, 17, 6821-6824.
376.
“(11R)-13-(Naphthylmethylamino)-4, 5-epoxy-11,13-dihydrocostunolide”. By Shama
Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63,
o4274.
377.
“(E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile”. By Vijayakumar N. Sonar,
Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o743-o745.
378.
“3-Ethyl-2-methyl-5-methylene-6,7-dihydroindol -4(5H)-one”. By Vijayakumar N. Sonar,
Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E64, 0158.
60
379.
“Carrrier Mediated Transport at the Blood-Brain Barrier for the Quaternary Ammonium
Nicotinic Receptor Antagonist, N, N’-Dodecyl-bis-picolinium bromide (bPiDDB)”. By
Paul R. Lockman, Werner J. Geldenhuys, Vamshi Manda, Fancy Thomas, Peter A.
Crooks, Linda P. Dwoskin and David D. Allen, J. Pharmacol. Exp. Therap., 2008, 324,
244-250.
380.
“Modern Instrumental Methods for Studying Mechanisms of Toxicology.” By Peter A.
Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy, and William S. Caldwell,
Invited Chapter in: Principles and Methods of Toxicology, Fifth Edition, Ed. A. Wallace
Hayes, Taylor & Francis, Philadelphia, 2008, Chapter 41, pp 2041-2112.
381.
“Region-specific Effects of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide
(bPiDDB) on Nicotine-induced Increase in Extracellular Dopamine In Vivo”. By Shafiqur
Rahman, Zhenfa Zhang, Roger L. Papke, Peter A. Crooks, Linda P. Dwoskin, and
Michael T. Bardo, Brit. J. Pharmacol., 2008, 153, 792-804.
382.
“(11R), (13R)-1-aminotetralino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim,
Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2008, E64, o639.
383.
“(11R)-13-(4-Hydroxyphenylethylamino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama
Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2008, 64E, o644.
384.
“Tetrabenzylpyrophosphate: An Efficient Catalyst for the Synthesis of Carboxamides
from Carboxylic Acids and Amines”. By Y. Thirapathy Reddy, P. Narsimha Reddy, P.
Raghotham Reddy, and Peter A. Crooks, Chem. Lett., 2008, 37(5), 528-529.
385.
“Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in
Rabbit Plasma after Sublingual Spray Delivery". By Ahmad Malkawi, Abeer M. AlGhananeem, and Peter A. Crooks, AAPS Journal, 2008, 10, 261-267.
386.
“In Vivo Evaluation of a Transdermal Codrug of 6-Beta-Naltrexol linked to
Hydroxybupropion in Hairless Guinea Pigs”. By Paul K. Kiptoo, Kalpana S. Paudel,
Dana C. Hammell, Mohamad O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb,
Europ. J. Pharm. Sci., 2008, 33, 371-379.
387.
“Sulfamic Acid: An Efficient, Cost-effective and Reusable Solid Acid Catalyst for the
Synthesis of 1, 8-Naphthyridines Under Solvent-free Heating and Microwave
Irradiation”. By Y. Thirupathi Reddy, P. Raghotham Reddy, B. Rajitha, M. Nikhil Reddy,
and Peter A. Crooks, Synth. Comm., 2008, 38, 3201-3207.
388.
“CuPy2Cl2: A Novel and Efficient Catalyst for Synthesis of Propargylamines
under Conventional Method and Microwave Irradiation”. By J. Venu Madhav, B. Suresh
Kuarm, P. Someshwar, B. Rajitha, Y.Thirupathi Reddy and Peter A. Crooks, Synth.
Comm., 2008, 32, 3215-3223.
389.
“Effect of Celecoxib and the Novel Anti-cancer Agent Dimethylamino-parthenolide in a
Developmental Model of Pancreatic Cancer”. By Michele Yip-Schneider, Huangbing Wu,
Victor Njoku, Matthew Ralstin, Bryan Holcomb, Peter Crooks, Sundar Neelakantan,
Christopher Sweeney, and C. Max Schmidt, Pancreas, 2008, 37, e45-53.
390.
“Ceric Ammonium Nitrate (CAN): An Efficient Catalyst for Coumarin Synthesis via
Pechmann Condensation using Conventional Heating and Microwave Irradiation”. By Y.
Thirupathi Reddy, Vijayakumar N. Sonar, Peter A. Crooks, Pavan K. Dasari, P.
61
Narsimha Reddy, and B. Rajitha, Synth. Comm., 2008, 38(12), 2082-2088.
391.
“The NF-κB Subunit, Rel A, is Associated with In Vitro Survival and Clinical Disease
Progression in Chronic Lymphocytic Leukemia and Represents a Promising Therapeutic
Target”. By Saman Hewamana, Suhair Alghazal, Thet Thet Lin, Mathew Clement, Chris
Jenkins, Monica Guzman, Craig T. Jordan, Sundar Neelakantan, Peter A. Crooks, Alan K.
Burnett, Guy Pratt, Chris Fegan, Clare Rowntree, Paul Brennan and Chris Pepper, Blood,
2008, 111, 4681-4689.
392.
“The Radiosensitizing Effects of L-Canavanine”. By David R. Worthen and Peter A.
Crooks, In: Herbal Radiomodulators: Applications in Medicine, Homeland Defence and
Space. Edit. Rajesh Arora, Chapter 18, pp 255-269, CABI Publishing, UK, 2008.
393.
“Extending the Analysis of Nicotinic Receptor Antagonists with the Study of Alpha6
Nicotinic Receptor Subunit Chimeras”. By Roger L. Papke, Linda P. Dwoskin, Clare
Stokes, Guangrong Zheng, Zhenfa Zhang, J. Michael McIntosh, and Peter A. Crooks,
Neuropharmacology, 2008, 54, 1189-1200.
394.
“Flux Across Microneedle-treated Skin is Increased by Increasing Charge of Naltrexone
and Naltrexol In Vitro”. By Stan L. Banks, Harvinder S. Gill, Mark R. Prausnitz, Peter A.
Crooks, and Audra L. Stinchcomb, Pharm. Research., 2008, 25, 1677-1685.
395.
“Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic
Acetylcholine Receptor–Ligands”. By Balwinder S. Bhatti, Jon-Paul Strachan, Scott R.
Breining, Craig H. Miller, Persida Tahiri, Peter A. Crooks, Niranjan Deo, Cynthia S. Day,
and William S. Caldwell, J. Org. Chem., 2008, 73, 3497-3507.
396.
“Dipyridine Cobalt Chloride: a Novel Catalyst for the Synthesis of Coumarins via
Pechmann Condensation”. J. Venu Madhav, B. Suresh Kuarm, P. Someshwar, B.
Rajitha, Y. Thirupathi Reddy, and Peter A. Crooks, J. Chem. Research, 2008, No. 4,
232-234.
397.
“N,N’-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of
Nicotine-induced Dopamine Release and Hyperactivity”. By Linda P. Dwoskin, Thomas E.
Wooters, Sangeetha P. Sumithran, Kiran B. Siripurapu, B. Matthew Joyce, Paul R.
Lockman, Vamshi K. Manda, Joshua T. Ayers, Zhenfa Zhang, J. Michael McIntosh, Peter
A. Crooks and Michael T. Bardo, J. Pharmacol. Exp. Therap., 2008, 326, 563-576.
398.
“Effects of Norketamine Enantiomers in Rodent Models of Persistent Pain”. By Joseph
R. Holtman, Jr., Peter A. Crooks, Jamie K. Johnson, Marhaba Hojahmat, Mark Kleven
and Elzbieta P. Wala, Pharm. Biochem. Behav., 2008, 90, 676-685.
399.
“Smoking Risk and the Likelihood of Quitting Among African American Female Light
and Heavy Smokers”. By Anita Fernander, Mitzi Schumacher, Xiaochen Wei, Peter
Wedlund, and Peter A. Crooks, J. National Medical Assoc., 2008, 100, 1199-1206.
400.
“Interaction Between Morphine and Norketamine Enantiomers in Rodent Models of
Nociception”. By Joseph R. Holtman, Peter A. Crooks, Jaime Johnson and Elzbieta P.
Wala, Pharmacol. Biochem. Behavior, 2008, 90, 769-777.
401.
“Pharmacokinetics of the Novel Nicotinic Receptor Antagonist, N,N’-dodecane-1,12-diylbis- picolinium dibromide (bPiDDB)”. By Zaineb A. Fadhel Albayati, Linda P. Dwoskin,
62
and Peter A. Crooks, Drug Metabolism and Disposition, 2008, 36, 2024-2029.
402. “Antileukemic Activity of Aminoparthenolide Analogs”. By Shama Nasim and Peter A.
Crooks, Bioorganic and Med. Chem. Letters, 2008, 18, 3870-3873.
403.
“Synthesis of Symmetrical 2,6-Disubstituted Granatanines”. By Ashish P. Vartak, Linda
P. Dwoskin, and Peter A. Crooks, Tetrahedron Lett., 2008, 49, 6330-6333.
404.
“tetrakis-Azaaromatic Quaternary Ammonium Salts: Novel Subtype-selective Antagonists
at Neuronal Nicotinic Receptors that Mediate Nicotine-evoked Dopamine Release”. By
Zhenfa Zhang, Guangrong Zheng, Marharyta Pivavarchyk, A. Gabriela Deaciuc, Linda
P. Dwoskin, and Peter A. Crooks, Bioorganic Med. Chem. Letters, 2008, 18, 57535757.
405.
“bis-Pyridinium Cyclophanes: Novel Ligands with High Affinity for the Blood-Brain Barrier
Choline Transporter”. By Zhenfa Zhang, Paul R. Lockman, Rajender K. Mittapalli, David D.
Allen, Linda P. Dwoskin and Peter A. Crooks, Bioorganic Med. Chem. Lett., 2008, 18, 56225625.
406.
“(Z)-4-[(3-((3-Oxoquinuclidin-2-ylidene)methyl]-1H-indol-1-yl)methylbenzonitrile”. By
Thirupathi Reddy Yerram Reddy, Narsimha Reddy Penthala, Sean Parkin and Peter A.
Crooks, Acta Crystallogr., Section E, 2008, E64, o2049.
407.
“(Z)-Methyl 4-{[3-(3-oxoquinuclidin-2-ylidene)methyl-1H-indol-1-yl]methyl}benzoate”. By
Thirupathi Reddy Yerram Reddy, Narsimha Reddy Penthala, Sean Parkin and Peter A.
Crooks, Acta Crystallogr., Section E, 2008, E64, o2050.
408.
“The Novel Nicotinic Receptor Antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium
Dibromide Decreases Nicotine-induced Dopamine Metabolism in Rat Nucleus
Accumbens”. By Shafiqur Rahman, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin,
and Michael T. Bardo, European Journal of Pharmacology, 2008, 601, 103-105.
409.
“(Z)-4-({3-[2,5-dioxoimidazolidin-4-ylidene)methyl]-1H-indol-1-yl}methyl)benzonitrile”. By
Narsimha Reddy Penthala, Thirupathi Reddy Yerram Reddy, Sean Parkin and Peter
A. Crooks, Acta Crystallogr. E, 2008, E64, o2122.
410.
“Synthesis and Evaluation of a Series of Homologous Analogues of Lobelane at the
Vesicular Monoamine Transporter-2”. By Guangrong Zheng, Linda P. Dwoskin and
Peter A. Crooks, Bioorg. Med. Chem. Lett., 2008, 18, 6509-6512.
411.
“Nuclear Factor-as a Potential Therapeutic Target for the Novel Cytoxic Agent LC-1 in
Acute Myeloid Leukaemia”. By Christopher Jenkins, Saman Hewamana, Amanada Gilkes,
Sundar Neelakantan, Peter A. Crooks, Ken Mills, Chris Pepper, and Alan Burnett, Br. J.
Haematol. 2008, 143, 661-671.
412.
“Synthesis and Biological Evaluation of Novel Substituted N1-[1-Benzyl-3-(3-tertbutylcarbamoyl-octahydroisoquinolin-2-yl)-2-hydroxypropyl]-2-[(2-oxo-2H-chromene-3carbonyl)amino]succinamide Analogs as Anti-Viral and Anti-HIV Agents”. By Y. Thirupathi
Reddy, P. Narsimha Reddy, Peter A. Crooks, Erik De Clercq, G. V. Panakala Rao, and B.
Rajitha, Heterocyclic Communications, 2009, 14 (6), 419-426.
413.
“Cellulose Sulfuric Acid: An Efficient Biodegradable and Recyclable Solid Acid Catalyst for
63
the One-pot Synthesis of Aryl-14H-dibenzo[a.j]xanthenes Under Solvent-free Conditions”.
By J. Venu Madhav, Y. Thirupathi Reddy, P. Narsimha Reddy, M. Nikhil Reddy, Suresh
Kuarm, Peter A. Crooks, and B. Rajitha, Journal of Molecular Catalysis-A, 2009. Chemical
304, 85-87.
414.
“Sulfamic Acid Catalyzed One-pot Synthesis of 2,5-Diaryl-1,3,4-Oxadiazoles Under
Microwave Irradiation and Conventional Heating”. By J. Venu Madhav, Y. Thirupathi
Reddy, P. Narsimha Reddy, Peter. A. Crooks, V. Naveen Kumar and B. Rajitha, J.
Heterocyclic Chemistry, 2009, 46, 289-293.
415.
“Cellulose Sulfuric Acid: An Efficient Biodegradable and Recyclable Solid Acid Catalyst
for the One-pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones”. By Penthala Narsimha
Reddy, Y. Thirupathi Reddy, M. Nikhil Reddy, Bavntula Rajitha, and Peter. A. Crooks,
Synth. Comm., 2009, 39, 1257-1263.
416.
“Human Skin Permeation of 3-O-Alkyl Carbamate Prodrugs of Naltrexone”. By Haranath
K. Vaddi, Stan L. Banks, Jianghong Chen, Dana C. Hammell, Peter A. Crooks, and
Audra L. Stinchcomb, J. Pharm. Sci., 2008, 98, 2611-2625.
417.
“A Scalable, Enantioselective Synthesis of the α2-Adrenergic Agonist, Lofexidine”. By
Ashish P. Vartak and Peter A. Crooks, Organic Process Research and Development,
2009, 13, 414-418.
418.
“N-Chlorosuccinimide is a Convenient Oxidant for the Synthesis of 2,4-Disubstituted 1,2,4Thiadiazolidine-3,5-diones”. By Shama Nasim and Peter A. Crooks, Tetrahedron Letters,
2009, 50, 257-259.
419.
“(Z)-Methyl-4-({3-[2,5-dioxoimidazolidin-4-ylidene)methyl]-1H-indol-1-yl}methyl)benzoate” By Narsimha Reddy Penthala, Thirupathi Reddy Yerram Reddy, Sean Parkin
and Peter A. Crooks, Acta Crystallogr. E, 2009, E65, o62-o63.
420.
“Nicotine Exposure can be Detected from LC-MS Analysis of Cerebrospinal Fluid from
Active and Passive Smokers”. By Ahmad Malkawi, Abeer Al-Ghananeem, Jose de
Leon,and Peter A. Crooks, Pharm. Biomed. Anal., 2009, 49, 129-132.
421.
“Transdermal Delivery of Bupropion and its Active Metabolite, Hydroxybupropion: A
Prodrug Strategy as an Alternative Approach”. By Paul K. Kiptoo, Kalpana S. Paudel,
Dana C. Hammell, Raghotham Reddy Pinninti, JianHong Chen, Peter A. Crooks, and
Audra L. Stinchcomb, J. Pharm. Sci, 2009, 98, 583-594.
422.
“Synthesis and Antitubercular Activity of a Series of Hydrazone and Nitrovinyl Analogs
Derived from Heterocyclic Aldehydes”, By Vijayakumar N. Sonar and Peter A. Crooks. J.
Enz. Inhibit. Medicin. Chem., 2009, 24(1), 117-124.
423.
“Targeting Reward-Relevant Nicotinic Receptors in the Discovery of Novel
Pharmacotherapeutic Agents to Treat Tobacco Dependence”. By Linda P. Dwoskin,
Marharyta Pivavarchyk, Barry M. Joyce, Nichole M. Neugebauer, Guangrong Zheng,
Zhenfa Zhang, Michael T. Bardo, and Peter A. Crooks, invited chapter, 55th Annual
Nebraska Symposium on Motivation: The Motivational Impact of Nicotine and its Role in
Tobacco Use. Eds. R.A. Bevins and A.R. Caggiula, Chapter 4, Nebr. Symp. Motiv.,
2009, 55, 31-63, Springer, NY.
64
424.
“Computational Neural Network Analysis of the Affinity of N-n-Alkylnicotinium Salts for
the α4β2* Nicotinic Acetylcholine Receptor”. By Fang Zheng, Chang-Guo Zhan, Linda
P. Dwoskin, and Peter A. Crooks, J. Enz. Inhibit. Med. Chem., 2009, 24 (1), 157-168.
425.
“3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazole-5-yl)-3-hydroxyindolein-2-one
Monohydrate”. By Narismha Reddy Penthala, Thirupathi Reddy Yerram Reddy, Sean
Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2009, E65, o552.
426.
“Cis-2,6-Dibenzylcyclohexanone”. By John P. Culver, Sean Parkin, and Peter A. Crooks,
Acta Crystallogr., Section E, 2009, E65, o551.
427.
“Indolyl-quinuclidinols Inhibit ENOX Activity and Endothelial Cell Morphogenesis While
Enhancing Radiation-mediated Control of Tumor Vasculature”. Ling Geng, Girish
Rachakonda, D. James Morré, Dorothy M. Morre3, Peter A. Crooks, Vijayakumar N.
Sonar, Joseph L. Roti Roti, Buck E. Rogers, Suellen Greco, Fei Ye, Kenneth J. Salleng,
Soumya Sasi, Michael L. Freeman, and Konjeti R. Sekhar, The FASEB Journal, 2009,
23, 2986-2995.
428.
“Design, Synthesis and VMAT2 Binding of Lobeline Analogs as Potential Therapeutic
Agents for Treating Psychostimulant Abuse”. Peter A. Crooks, Guangrong Zheng, Ashish
Vartak, John Culver, Fang Zheng, A. Gabi Deaciuc, and Linda P. Dwoskin, Current Topics
in Medicinal Chemistry, Volume 9, 2010, pp xxx-xxx, Bentham Science, , in press, 2010.
429.
“The Novel Nicotinic Receptor Antagonist, N,N’-Dodecane-1,12-diyl-bis-3-picolinium
Dibromide (bPiDDB), Inhibits Nicotine-Evoked [3H]Norepinephrine Overflow from Rat
Hippocampal Slices”. By Andrew M. Smith, Gurpreet K. Dhawan, Zhenfa Zhang, Kiran B.
Siripurapu, Peter A. Crooks and Linda P. Dwoskin, Biochemical Pharmacology, 2009, 78,
889-897.
430.
“Codrugs and Hybrid Drugs”. By Peter A. Crooks, Harpreet Dhooper and Ujjwal
Chakravorty, in Prodrugs and Targeted Delivery, Edit Jarkko Rautio, Invited Chapter,
Wiley-VCH, New York, 2009.
431.
“Nicotinic Receptor-based Therapeutics and Candidates for Smoking Cessation”.
By Linda P. Dwoskin, Andrew M. Smith, Thomas E. Wooters, Zhenfa Zhang, Peter A.
Crooks, and Michael T. Bardo, Biochemical Pharmacology, 2009, 78, 732-743.
432.
“QSAR Study on Maximal Inhibition (Imax) of Quaternary Ammonium Salts for S-(-)Nicotine–evoked Dopamine Release from Dopaminergic Terminals in Rat Striatum”. By
Fang Zheng, Mathew McConell, Chang-Guo Zhan, Linda P. Dwoskin, and Peter A.
Crooks, Bioorganic Medicinal Chemistry, 2009, 17, 4477-4485.
433.
“Aminoparthenolides as Novel Anti-leukemic Agents: Discovery of the NF-B Inhibitor,
DMAPT (LC-1)”. By Sundar Neelakantan, Shama Nasim, Monica Guzman, Craig T. Jordan
and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2009, 19, 4346-4349.
434.
“Improved and Scalable Synthetic Route to the Synthon 17--(2-carboxyethyl)-1,3,5estratriene: an Important Intermediate in the Synthesis of Bone-Targeting Estrogens”. By
Shama Nasim, William M. Pierce, Jr., K. Grant Taylor, and Peter A. Crooks, Synth.
Comm., 2010, 40(5), 772-781.
435.
“rac- and (+)-[4,4’,5,5’-2H4]-2-(2’,6”-Dichlororphenoxy]-ethyl)-2-imidazoline (Lofexidine)”. By
Ashish P. Vartak, Vijayakumar Sonar, and Peter A. Crooks, J. Labelled Comp.
Radiopharmaceuticals, 2009, 52, 431-434.
65
436.
“Selective Inhibition of Acetylcholine-evoked Responses of 7 Neuronal Nicotinic
Acetylcholine Receptors by Novel tris- and tetrakis-Azaaromatic Quaternary Ammonium
Antagonists”. By Gretchen Y. López-Hernández, Jeffrey S. Thinschmidt, Guangrong Zheng,
Zhenfa Zhang, Peter A. Crooks, Linda. P. Dwoskin, and Roger L. Papke, Mol. Pharmacol.,
2009, 76, 652-666.
437.
“(11R)-13-[Dimethylamino]-4,5-epoxy-11,13-dihydrocostunolide Monofumarate Salt”. By
Neelakantan Sundar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., E., 2009, E65,
o1569.
438.
“A Convenient and Scalable Process for the Preparation of Bupropion Hydrochloride via
Efficient Bromination using N-Bromosuccinimide”. By Y. Thirupathi Reddy, P. Narsimha
Reddy, M. Nikhil Reddy, B. Rajitha and Peter A. Crooks, Synth. Comm., in press, 2010.
439.
“Stereocontrolled Synthesis and Pharmacological Evaluation of cis-2,6-Diphenethyl-1azabicyclo[2.2.2]octanes as Lobelane Analogues”. By Guangrong Zheng, Linda P.
Dwoskin, Agripina G. Deaciuc, Peter A. Crooks, J. Org. Chem., 2009, 74, 6072-6076.
440.
“In vivo Evaluation of Diaminodiphenyls: Anticonvulsant Agents with Minimal Acute
Neurotoxicity”. By David R. Worthen, Aimee K. Bence, James P. Stables, and Peter A.
Crooks, Bioorganic Med. Chem. Lett., 2009; 19, 5012-5015.
441.
“rac-2-(2-Amino-4-oxo-4,5-dihydrothiazol-5-yl)-2-hydroxy-1H-indene-1,3-dione”. By
Narsimha R. Penthala, Thirupathi R. Y. Reddy, Sean Parkin, and Peter A. Crooks,
Acta Crystallogr., E, 2009, E65, o1877.
442.
“Pyrrolidine Analogs of Lobelane: Relationship of Affinity for the Dihydrotetrabenazine
Binding Site with Function of the Vesicular Monoamine Transporter 2 (VMAT2)”. By
Ashish P. Vartak, Justin R. Nickell, Jaturaporn Chagkutip, Linda P. Dwoskin, and Peter A.
Crooks, J. Med. Chem., 2009, 52, 7878-7882.
443.
“Synthesis of Novel Isoluminol Probes and their Use in Rapid Bacterial Assays”. By
Sundar Neelakantan, Iwan Surjawan, Huseyin Karacelik, Clair L. Hicks and Peter A.
Crooks, Bioorg. Med. Chem. Lett., 2009, 19, 5722-5726.
444.
“First Principles Determination of Molecular Conformations of Indolizidine (-)-235B’ in
Solutions”. By Fang Zheng, Linda P. Dwoskin, Peter A. Crooks, and Chang-Guo Zhan,
Theor. Chem. Acc., 2009, 124, 269-278.
445.
“Mecamylamine, Dihydro-beta-erythroidine, and Dextromethorphan Block Conditioned
Responding Evoked by the Conditional Stimulus Efects of Nicotine”. By Amanda M.
Struthers, Jamie L. Wilkinson, Linda P. Dwoskin, Peter A. Crooks, and Rick A. Bevins,
Pharm. Biochem. Behav., 2009; 94, 319-328.
446.
“3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxy-1-phenylindolin-2-one
Ethanol solvate”. By Narisimha R. Penthala, Thirapathi R. Y. Reddy, Sean Parkin, and
Peter A. Crooks, Acta Cryst., Section E, 2009, E65, o2909-o2910.
447.
“3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-5-fluoro-3-hydroxy 1-phenylindolin-2-one Methanol hemisolvate”. By Narisimha R. Penthala, Thirapathi R. Y. Reddy,
Sean Parkin, and Peter A. Crooks, Acta Cryst., Section E, 2009, E65, o2439-02440.
66
448.
"Lobelane Inhibits Methamphetamine-Evoked Dopamine Release via Inhibition of the
Vesicular Monoamine Transporter-2”. By Justin R. Nickell, Sairam Krishnamurthy,
Seth Norrholm, Gabriela Deaciuc, Guangrong Zheng, Peter A. Crooks and Linda P.
Dwoskin, J. Pharm. Exp. Therap., 2010, 332, 612-621.
.
449.
“The Analgesic and Toxic Effects of Nornicotine Enantiomers Alone and in Interaction with
Morphine in Rodent Models of Acute and Persistent Pain”. By Joseph R. Holtman, Peter A.
Crooks, Jaime K. Johnson-Hardy, Elzbieta P. Wala, Pharm. Biochem. Behav., 2010, 94,
352-362.
450.
“An Expeditious Pechman Condensation by Using Biodegradable Cellulose Sulphuric Acid
as Solid Acid Catalyst”. By J. Venu Madhav, Thirupathi R. Y. Reddy, Peter A. Crooks and
Bavntula Rajitha Synthetic Communications, Manuscript No. LSYC-2009-333, accepted for
publication, 2009.
451.
“Microwave Assisted Synthesis and In Vitro Cytotoxicities of Substituted (Z)-2-Amino-5-(1benzyl-1H-indol-3-yl) methylene-1-methyl-1H-imidazol-4(5H)-ones Against Human Tumor
Cell Lines. By Narsimha Reddy Penthala, Thirupathi Reddy Yerramreddy, and Peter A
Crooks, Bioorg. Med. Chem. Lett., 2010, 20, 591-593.
452.
“Novel substituted (Z)-5-((N-Benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5((N-Benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as Potent Radiosensitizing Agents” By Y. Thirupathi Reddy, Konjeti R. Sekhar, Nidhish Sasi, P.Narsimha
Reddy, Michael L. Freeman, and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2010, 20, 600602.
453.
“Aplysinopsin Analogs: Microwave-assited Synthesis and Anti-proliferative Activity of Novel
Substituted (Z)-5-(N-Benzylindol-3-yl)methylene)imidazolidine-2,4-diones”. By Y. Thirupathi
Reddy, P. Narsimha Reddy, Srinivas Koduru, Chendil Damodaran, and Peter A. Crooks,
Europ. J. Med. Chem., 2009, EJMECH-D-09-00818, accepted for publication subject to
revision.
454.
“1-Methyl-2,6-cis-distyrylpiperidine”. Guangrong Zheng, Sean Parkin, Linda P. Dwoskin
and Peter A. Crooks, Acta Cryst., Section E, 2010, E66, o77.
455.
“1-Methyl-2S,6S-trans-distyrylpiperidinium chloride”. Guangrong Zheng, Sean Parkin,
Linda P. Dwoskin and Peter A. Crooks, Acta Cryst., Section E, 2010, E66, o78.
456.
“Lobeline Esters as Novel Ligands for Neuronal Nicotinic Acetylcholine Receptors and
Neurotransmitter Transporters”. By Marhaba Hojahmat, David Horton, Seth D.
Norrholm, A. Gabriela Deaciuc, Vladimir Grinevich, Dennis K. Miller, Linda P. Dwoskin,
and Peter A. Crooks, Bioorg. Med. Chem., 2010, 18, 640-649.
457.
“Transdermal Delivery of Naltrexol and Skin Permeability Lifetime after Microneedle
Treatment in Hairless Guinea Pigs In Vivo”. Stan L. Banks, Raghotham R. Pinninti,
Harvinder S. Gill, Peter A. Crooks, Mark R. Prausnitz, and Audra L. Stinchcomb, J.
Pharm. Sci., 2010, in press, JPS-09-572.R1(22083), DOI: 10.1002/jps.
458.
“Novel bis-2,2,5,5-Tetramethylpiperidine and bis-Mecamylamine Antagonists at Neuronal
Nicotinic Receptors that Mediate Nicotine-evoked Dopamine Release”. By Zhenfa Zhang,
Marharyta Pivavarchyk, Karunai Leela Subramanian, A. Gabriela Deaciuc, Linda P.
Dwoskin, and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2010, 20, 1420-1423.
459.
“Predictive Screening Model for Potential Vector-Mediated Transport of Cationic Substrates
67
at the Blood-Brain Barrier Choline Transporter”. By Werner J. Geldenhuys, Vamshi K.
Manda, Rajender K. Mittapalli, Cornelis J. Van der Schyf, Peter A. Crooks, Linda P.
Dwoskin, David D. Allen and Paul R. Lockman, Bioorg. Med. Chem. Lett., 2010, 20, 870877.
460.
“Cellulose Sulfuric Acid: Novel and Efficient Biodegradable and Recyclable Acid Catalyst
for the Solid State Synthesis of Thiadiazolo Benzimidazoles”. By B. Suresh Kuarm, J.
Venu Madhav, Bavntula Rajitha, Y.Thirupathi Reddy, P. Narsimha Reddy, and Peter A.
Crooks, Synth. Commun., accepted for publication, 2010.
461. “A Water Soluble Parthenolide Analogue Suppresses In Vivo Prostate Cancer Growth
by Targeting NF-κB and Generating Reactive Oxygen Species”. By Rajasubramaniam
Shanmugam, Praveen Kusumanchi, Liang Cheng, Peter A. Crooks, Sundar Neelakantan,
William Matthews, Harikrishna Nakshatri, and Christopher J. Sweeney, The Prostate,
2010, PROS-09-404, in press.
462. “A NADPH Oxidase-Dependent Redox Signaling Pathway Mediates the Selective
Radiosensitization Effect of Parthenolide in Prostate Cancer Cells”. By Yulan Sun, Daret
St Clair, Yong Xu, Peter A. Crooks, and William St Clair, Cancer Research, 2010, in
press.
68
Manuscripts submitted for publication
"Synthesis and Nicotine Receptor Binding Affinity of 2-(3-Pyridyl)quinuclidines, Conformationally
Restricted Analogs of Anabasine." By Niranjan M. Deo and Peter A. Crooks, J. Heterocyclic
Chem., submitted, 2009.
"A Phytochemical and Phytopharmacological Review on the Seeds of Nigella sativa L. " By
Alison Anderson, Omar A. Ghosheh and Peter A. Crooks, J. Ethnopharmacol., submitted, 2009.
"Rapid and Simple High Performance Liquid Chromatographic Assay for 5-Fluorouracil in
Human Plasma and Vitreous Humor”. By Michelle Howard, Tadeusz Cynkowski, Grazyna
Cynkowski, and Peter A. Crooks, J. Pharm. Biomed. Anal., submitted, 2009.
"Commentary: Mechanism of Aspirin Hydrolysis: A Revisitation." By Anwar A. Hussain and Peter
A. Crooks, Pharmaceutical Research, submitted, 2009.
“Lobeline Analogs Inhibit Nicotinic Receptors Mediating Nicotine-Evoked [3H]Dopamine and
[3H]Norepinephrine Release”. By Dennis K. Miller, Guangrong Zheng, Sangeetha P. Sumithran,
Gurpreet Dhawan, Peter A. Crooks and Linda P. Dwoskin, J. Pharm. Exp. Therap., submitted,
2009.
“Lobeline Analogs Inhibit Methamphetamine-Evoked Dopamine Release and [3H]Dihydrotetrabenazine Binding to the Vesicular Monoamine Transporte”. By Sairam Krishnamurthy,
Guangrong Zheng, Agripina G. Deaciuc, Lana Ng, Seth D. Norrholm, Peter A. Crooks and
Linda P. Dwoskin, J. Pharmacol. Exp. Ther., submitted, 2009.
“The Novel Anti-leukemic Agent LC-1, is Preferentially Cytotoxic in CLL Cells Derived from
Poor Prognostic Subsets Including those with Clinical Resistance to Fludarabine”. By Chris
Pepper, Paul Brennan, Saman Hewamana, Chris Jenkins, Monica Guzman, Craig Jordan,
Sundar Neelakantan, Peter A. Crooks, and Chris Fegan, Cancer Research, in review, 2009.
“Supression of Manganese Superoxide Dismutase Induction Reveals a Transcriptional-based
Mechanism for the Selective Radiosensitization of Prostate Cancer Cells by Parthenolide”. By
Yulan Sun, Daret St. Clair, Ines Batinic-Haberle, Fang Fang, Graham Warren, Peter A. Crooks,
and William H. St. Clair, Cancer Research, submitted, 2009.
“Parthenolide Analogue LC-1 has Anti-cancer Activity in Human Oral Squamous Cell
Carcinoma”. By Pradeep C. Adatrow, Rajasubramaniam Shanmugam, Jaya L. Adabala, Steven
B. Blanchard, Sundar Neelakantan, Peter A. Crooks, L. Jack Windsor and Christopher J.
Sweeney, Oral Oncology, in review, 2009.
“Development of Guanylated Nicotine Analogs: Ligands for α42 and α7 Neuronal Nicotinic
Acetylcholine Receptor Subtypes”. By Aaron J. Haubner, Emily J. Kennard, Joshua R. Ring,
Agripina G. Deaciuc, May C. Fu, John M. Littleton, Linda P. Dwoskin and Peter A. Crooks,
Bioorg. Med. Chem., submitted, 2009.
“Effect of 8-Hydroxyl Esterification of Lobeline on Activity at Nicotinic Receptors and
neurotransmitter Transporters”. By Seth D. Norrholm, Dennis K. Miller, Peter A. Crooks,
Marhaba Hojhamat, Vladimir Grinevich, and Linda P. Dwoskin, J. Pharmacol. Exp. Ther.,
submitted, 2009.
69
“Supression of Pancreatic Tumor Growth by Combination Therapy with Sulindac and LC-1 is
Associated with Cyclin D1 Inhibition In Vivo”. By Michele T. Yip-Schneider, Huangbing Wu,
Matthew Ralstin, Constantin Yiannoutsos, Peter A. Crooks, Sundar Neelakantan, Steven Noble,
Harikrishna Nakshatri, Christopher J. Sweeney, and C. Max Schmidt, Mol. Cancer Therapeutics,
submitted, 2009.
“Preparation of 2-(Heterocyclicmethoxy)pyridines As Neuronal Nicotinic Receptor Ligands”. By
Jianghong Chen, Peter A. Crooks, Linda P. Dwoskin, and Donglu Bai, Bioorganic and Medicinal
Chemistry Letters, in preparation, 2009.
“Agmatine Analogs as N-Methyl-D-Aspartate Receptor Inhibitory Modulators”. By Joshua R. Ring,
Aaron J. Haubner, John M. Littleton, and Peter A. Crooks, Biorg. Med. Chem., submitted, 2009.
“Preclinical Pharmacokinetic Evaluation of Z-(±)-2-(1-Benzenesulfonyl-1H-indol-3-ylmethylene)1-azabicyclo[2.2.2]octan-3-one (BSAO); a Novel Radio-sensitization Agent”. By Abeer M. AlGhananeem, Ahmad H. Malkawi, Zaineb F. Al-Bayati, Michael L. Freeman and Peter A. Crooks,
AAPS Journal, submitted, 2009.
“bis-Pyridinium Analogs with High Affinity for the Blood-Brain Barrier Choline Transporter”. By
Zhenfa Zhang, Paul R. Lockman, Werner J. Geldenhuys, David D. Allen, Linda P. Dwoskin and
Peter A. Crooks, Bioorganic Med. Chem. Letters, submitted, 2009.
“An Expiditious Synthesis of cis-2,3,3a,4,5,9b-Hexahydro-1-methyl-1H-pyrrolo-[3.2h]isoquinoline/[2,3-f]quinoline via [3+2] Cycloaddition”. By Zhenfa Zhang, Linda P. Dwoskin and
Peter A. Crooks, Organic Letters, ol-2009-029098, submitted, 2009.
“meso-Transdiene, a Defunctionalized Analog of α-Lobeline Inhibits Dopamine and Serotnin
Uptake into Rat Striatal and Hippocampal Synaptosomes”. By Steven B. Harrod, Peter A.
Crooks, M. J. Jenkins, J. Zhu, Guangrong Zheng, A. Gabi Deaciuc, and Linda P. Dwoskin,
J. Pharm. Exp. Ther., submitted, 2009.
“Bridged Amidino Nicotine Analogs: Subtype-selective, High Affinity Ligands for the Neuronal
Nicotinic Receptor”. By Aaron J. Haubner, Jianhong Chen, Emily J. Kennard, Gareth Young,
Roger L. Papke, Neil S. Millar, Linda P. Dwoskin and Peter A. Crooks, Bioorg. Med. Chem. Lett.,
submitted, 2009.
“Guanylated Nicotine Analogs: Ligands for α4β2* and α7* Neuronal Nicotinic Receptor
Subtypes”. By Aaron J. Haubner, Emily J. Kennard, Joshua R. Ring, May C. Fu, John M.
Littleton, Linda P. Dwoskin, and Peter A. Crooks, Bioorg. Med. Chem. Lett., submitted, 2009.
“Synthesis and Pharmacological Evaluation of Heterocycle Substituted Analogs of the Alkaloid,
Lobelane”. By Ashish P. Vartak, Jaturaporn Chagkutip, A. Gabi Deaciuc, Linda P. Dwoskin, and
Peter A. Crooks, Bioorg. Med. Chem. Lett., submitted, 2009.
“Novel bis-, tris-, and tetrakis-Tertiary Amine Antagonists at Neuronal Nicotinic Receptors that
Mediate Nicotine-evoked Dopamine Release”. By Zhenfa Zhang, Guangrong Zheng, Marharyta
Pivavarchyk, A. Gabriela Deaciuc, Linda P. Dwoskin and Peter A. Crooks, Bioorganic and
Medicinal Chemistry Letters, submitted, 2009.
“Supression of FOXO3a Reveals a Novel Mechanism for the Selective Radiosensitization Effect
of Parthenolide in Prostate Cancer” By Yulan Sun, Yong Xu, Daret K. St. Clair, Peter A. Crooks,
and William H. St. Clair, Mol. Cancer Therap., submitted, 2008.
70
“Dimethylaminoparthenolide (DMAPT) is an Active In Vivo Agent for Prostate Cancer, and Cell
Death is Associated with Generation of Oxidative Stress, c-Jun N-terminal Kinase Activation,
and Inhibition of Nuclear Factor Kappa B (NFkB)”. By Rajasubramaniam Shanmugam,
Praveen Kasumanchi, Peter A. Crooks, Craig Jordan, William Matthews, Harikrishna
Nakshatri, and Christopher J. Sweeney, Clinical Cancer Research, submitted, 2009.
“Discovery of IEB-TDZD, a Potent and Selective Antileukemic 1,2,4-Thiadizolidine,3,5-dione
Analog”. By Shama Nasin, Monica Guzman, Craig Jordan, and Peter A. Crooks, Bioorg Med.
Chem., submitted 2009.
“Mechanistic Insights into the Anti-cancer Activity of Dimethylaminoparthenolide (DMAPT) in
both Early and Late Smoking Related Cancers - Non-small Cell Lung Cancer (NSCLC) and
Transitional Cell Carcinoma (TCC)”. By Rajasubramaniam Shanmugam, Praveen Kusumanchi,
Peter A. Crooks, Sundar Neelakantan. Tyler Peat, James Klaunig, Craig Jordan, William Matthews,
Harikrishna Nakshatri, Christopher J Sweeney, Clinical Cancer Research, submitted, 2009.
“The Pyrrolidine Analog of nor-Lobelane, cis-2,5-di-(2-Phenethyl)-pyrrolidine Hydrochloride,
Inhibits VMAT2 Function, Dopamine Release, and Methamphetamine Self-administration in Rats”.
Joshua Beckmann, Kiran Siripurapu, Justin Nickell, Emily Denehy, Ashish Vartak, Peter A.
Crooks, Linda P. Dwoskin, and Michael T. Bardo. J. Pharmacol. Exp. Ther., submitted, 2009.
”The NF-κB Inhibitor LC-1 has Single Agent Activity in Multiple Myeloma Cells and Synergises
with Bortezomib”. By Elisabeth Walsby, Guy Pratt, Saman Hewamana, Peter A. Crooks, Alan
Burnett, Chris Fegan, Chris Pepper. Blood, submitted, 2009; BLOOD/2009/251025.
“Aplysinopsin Analogs: Microwave-assisted Synthesis and Anti-proliferative Activity of Novel
Substituted (Z)-5-(N-Benzylindol-3-yl)methylene)imidazolidine-2,4-diones”. By Y. Thirupathi Reddy,
P. Narsimha Reddy, Srinivas Koduru, Chendil Damodaran, and Peter A. Crooks, Europ. J. Med.
Chem., submitted, 2009.
“CuPy2Cl2: An Efficient Recyclable Solid Acid Catalyst for the Solvent-free Synthesis of 2-Amino
thiazole/selenazole-5-carboxylic Esters in the Presence of N-Bromosuccinimide”. J. Venu Madhav,
Y. Thirupathi Reddy, B. Suresh Kuarm, Peter A. Crooks and B. Rajitha. Chem. Lett. (manuscript in
the preparation).
“Design, Synthesis and Anti-proliferative Activity of Novel Resveratrol Analogs”. M. Nikhil Reddy,
Srinivas Koduru, Y. Thirupathi, Reddy, P. Narsimha Reddy, Damodaran Chendil, and Peter A.
Crooks. Bioorg. Med. Chem. Lett. (manuscript in the preparation).
“Design, Synthesis and Anti-proliferative Activity of Novel Parthenolide Analogs”. M. Nikhil Reddy,
Srinivas Koduru, Y. Thirupathi, Reddy, P. Narsimha Reddy, Damodaran Chendil, and Peter A.
Crooks. Bioorg. Med. Chem. Lett. (manuscript in the preparation).
“Quinlobelane: a Water-soluble Analog of Lobelane with VMAT2 Inhibitory Properties”. By Ashish
P. Vartak, Agripina G. Deaciuc, Linda P. Dwoskin and Peter A. Crooks, Bioorg. Med. Chem. Lett.,
submitted, 2009; BMCL-D-10-00262.
“A Novel 62* Nicotinic Receptor Antagonist Selectively Blocks Abuse-Related Effects of
Nicotine”. By Thomas E. Wooters, Andrew M. Smith, Marharyta Pivavarchyk, Kiran B.
Siripurapu, J. Michael McIntosh, Zhenfa Zhang, Peter A. Crooks, Michael T. Bardo and Linda
P. Dwoskin, J. Neurochem., submitted, 2009.
“A Convenient and Scalable Synthesis of S-(-)-Nornicotine from S-(-)-Nicotine with Retention
of Configuration at the Pyrrolidine-2 Carbon Utilizing Manganese Dioxide-mediated Oxidative
71
N-demethylation”. By Marhaba Hojhamat, Xiaochen Wei, and Peter A. Crooks, Chirality,
submitted, 2009.
“Repeated Nicotine Treatment Increases bPiDDB Potency to Inhibit 62* Nicotinic
Receptor-mediated Nicotine-evoked Dopamine Release”. By Andrew M. Smith, Marharyta
Pivavarchyk, Tom E. Wooters, Zhenfa Zhang, Guangrong Zheng, J. Michael McIntosh,
Peter A. Crooks, Michael T. Bardo and Linda P. Dwoskin, Biochemical Pharmacology,
submitted, 2009.
“Antinociceptive Effects and Toxicity of Morphine-6-O-sulfate in Rodent Models of Pain”. By
Joseph R. Holtman, Jr., Peter A Crooks, Jamie Johnson-Hardy, and Elzbieta P. Wala, Europ.
J. Pharmacol., submitted, 2009.
“An NADPH Oxidase-dependent Redox Signaling Pathway Mediates the Selective
Radiosensitization Effect of Parthenolide in Prostate Cancer Cells”. By Yulan Sun, Daret K. St.
Clair, Yong Xu, Peter A. Crooks, and William H. St. Clair, Cancer Research, submitted, 2009.
"A Water-soluble Parthenolide Analogue Suppresses In Vivo Tumor Growth of Two Tobacco
Associated Cancers, Lung and Bladder cancer, by Targeting NF-κB and Generating Reactive
Oxygen Species." By Rajasubramaniam Shanmugam, Praveen Kusumanchi, Peter A. Crooks,
Sundar Neelakantan. Tyler Peat, James Klaunig, Craig Jordan, William Matthews, Harikrishna
Nakshatri, and Christopher J. Sweeney, Carcinogenesis, submitted, 2009; CARCIN-2009-01146.
“Bioavailability of 9-Tetrahydrocannabinol Following Intranasal Administration of a
Mucoadhesive Gel Spray Delivery System in Conscious Rabbits”. By Abeer M. Al-Ghananeem,
Ahmad H. Malkawi, Peter A. Crooks, Drug Development and Industrial Pharmacy, submitted,
2010.
In Vitro Permeation of a Pegylated Naltrexone profdrug Across Microneedle-treated Skin”. By
Mikolaj Milewski, Thirupathi Reddy Yerramreddy, Priyanka Ghosh, Peter A. Crooks, and Audra
L. Stinchcomb, J. Controlled Release, submitted, 2010.
“Design and Synthesis of Novel 3-O-Pegylated Carboxylate and 3-O-Pegylated Carbamate
Prodrugs of Naltrexone for Microneedle-Enhanced Transdermal Drug Delivery”. By Thirupathi
Reddy Yerramreddy, Mikolaj Milewski, Narsimha Reddy Penthala, Audra L. Stinchcomb, and
Peter A. Croooks, Molecules, submitted 2010.
“3-O-Phosphate Ester Prodrugs of Estradiol as Bone-Targeted Agents for Osteoporosis”. By
Shama Nasim, Ashish P. Vartak, William M. Pierce, Jr., K. Grant Taylor and Peter A. Crooks,
Bioorg. Med. Chem. Lett., submitted, 2010.
72
Symposium Abstracts
1.
"Formation of an Alpha-Pyridone Metabolite of Metyrapone by Rat Hepatic Soluble
Enzymes". Lyaquatali A. Damani, and Peter A. Crooks, 41st International Congress of
Pharmaceutical Sciences of the Federation of International Pharmacists, Proc. 41st. Int.
Congr. Pharm. Sci., September, 1981, Vienna, Austria; 1981, 103 (Abstract No. 28).
2.
"Conformation Requirements for Selectivity of Agonists at Post Synaptic Alpha 2Receptors". Peter Hicks, Christopher Waldron, Peter Burn, and Peter A. Crooks,
Proceedings of the British Hypertension Society, September, 1982, Oxford, UK; (Abstract
No. 53).
3.
"Inhibition of Bacterial DNA Methylation by Synthetic Analogs of S-Adenosyl-Lhomocysteine", Peter A. Crooks, Malcolm J. Tribe, and Richard J. Pinney, American
Pharmaceutical Association Academy of Pharmaceutical Sciences, 33rd National
Meeting, November 1982, San Diego, CA, USA; Proc. Acad. Pharm. Sci., 1982, 12 (2),
151 (Abstract No. 18).
4.
"Synthesis of Novel Nucleosides as Potential Inhibitors of mRNA Guanine 7Methyltransferase," Eric Benghiat, and Peter A. Crooks, American Pharmaceutical
Association Academy of Pharmaceutical Sciences, 33rd National Meeting, November,
1982, San Diego, CA, USA; Proc. Acad. Pharm. Sci., 1982, 12 (2), 152 (Abstract No. 20).
5.
"High-Performance Liquid-Chromatographic Determination of the In Vivo N-Methylation
of 14C-nicotine in the Guinea Pig", Kenneth C. Cundy, and Peter A. Crooks, American
Pharmaceutical Association Academy of Pharmaceutical Sciences, 33rd National
Meeting, November, 1982, San Diego, CA, USA; Proc. Acad. Pharm. Sci., 1982, 12 (2),
151 (Abstract No. 19).
6.
"In Vitro Methylation of Nicotine in the Guinea Pig." C. Steven Godin, and Peter A.
Crooks, 35th National Meeting of the Academy of Pharmaceutical Sciences, American
Pharmaceutical Association, Miami Beach, Florida, Nov., 1983; Proc. Acad. Pharm. Sci.,
1983, 13(2), 174 (Abstract No. 8).
7.
"Unexpected Phenomenon in the High-Performance Liquid-Chromatography of
Radiolabeled Nicotines-Separation of Enantiomers in an Achiral System". Kenneth C.
Cundy, and Peter A. Crooks, 35th National Meeting of the Academy of Pharmaceutical
Sciences, American Pharmaceutical Association, Miami Beach, Florida, November, 1983;
Proc. Acad. Pharm. Sci., 1983, 13(2), 177 (Abstract No. 20).
8.
"Pulmonary Metabolism of Enkephalins," Peter A. Crooks, Jerzy Krechniak, Jack W.
Olson, Ralph J. Altiere, and Mark N. Gillespie, American Physiological Society, 35th
Annual Fall Meeting, Lexington, Kentucky, August, 1984; Physiologist, 1984, 27, 239,
Abstract 25.7.
9.
"Stereochemical Assignments in Benzonorbornenes Using 2-D NMR Spectroscopy".
Carolyn P. Brock, Peter A. Crooks, W. John Layton, and Stanford L. Smith, Proceedings
of the 16th South-Eastern Magnetic Resonance Conference, Lexington, Kentucky,
October, 1984, PII, Abstract No. 10, p41.
73
10.
"Inhibition of Vaccinia mRNA Guanine 7-Methyltransferase by Multisubstrate Adducts,"
Eric Benghiat, and Peter A. Crooks, 37th National Meeting of the Academy of
Pharmaceutical Sciences, American Pharmaceutical Association, Philadelphia, PA,
October, 1984; Proc. Acad. Pharm. Sci., 1984, 14(2), 210 (Abstract No. 13).
11.
"N-Methylnornicotinium Ion - A New In Vivo Metabolite of D-Nicotine Isolated from
Guinea Pig Urine". Michio Sato, and Peter A. Crooks, 37th National Meeting of the
Academy of Pharmaceutical Sciences, American Pharmaceutical Association,
Philadelphia, Pennsylvania, October, 1984; Proc. Acad. Pharm. Sci., 14(2), 210 (Abstract
No. 12).
12.
"Nuclear Magnetic Resonance Spectroscopic Analysis of Nicotine Enantiomers". C.
Steven Godin, William F. Pool, and Peter A. Crooks, 37th National Meeting of the
Academy of Pharmaceutical Sciences, American Pharmaceutical Association,
Philadelphia, PA, October, 1984; Proc. Acad. Pharm. Sci., 1984, 14(2), 208 (Abstract No.
5).
13.
"Nicotine Racemization During Cigarette Smoking," William F. Pool, C. Steven Godin,
and Peter A. Crooks, Society of Toxicology Annual National Meeting, San Diego, CA,
March, 1985; The Toxicologist, 1985, 5(1), 232 (Abstract No. 925).
14.
"In Vivo Metabolism of R-(+)-[14C-NCH3]-Methylnicotinium ion in the Guinea Pig", William
F. Pool, and Peter A. Crooks, 45th International Congress of Pharmaceutical Sciences of
the Federation of International Pharmacists, Montreal, Canada, September, 1985; Proc.
45th Int. Congr. Pharm. Sci., 1985, 114 (Abstract No. 165), p. 114.
15.
"In Vitro Inhibition of Histamine N-Methylation in Guinea Pig Lung Homogenate by S(-)-Nicotine", C. Steven Godin, and Peter A. Crooks, 45th International Congress of
Pharmaceutical Sciences of the Federation of International Pharmacists, Montreal,
Canada, September, 1985; Proc. 45th Int. Congr. Pharm. Sci., 1985, 114 (Abstract No.
166), p. 114.
16.
"Nicotine Racemization During Smoking", C. Steven Godin, William F. Pool, and Peter A.
Crooks, 45th International Congress of Pharmaceutical Sciences of the Federation of
International Pharmacists, Montreal, Canada, September, 1985; Proc. 45th Int. Congr.
Pharm. Sci., 1985, 79 (Abstract No. 104), p.79..
17.
"High Performance Liquid Chromatographic Separation and Electrochemical Detection of
Nicotine and N-Methylnicotinium ion", Abdulghani A. Houdi, Shaker Mousa, Glenn R.
Vanloon, and Peter A. Crooks, 45th International Congress of Pharmaceutical Sciences
of the Federation of International Pharmacists, Montreal, Canada, September, 1985;
Proc. 45th Int. Congr. Pharm. Sci., 1985, 79 (Abstract No. 105), p. 79.
18.
"A Simple, Sensitive Determination of Histamine and N-Methylhistamine in Biological
Fluids by HPLC with Electrochemical Detection", Abdulghani A. Houdi, and Peter A.
Crooks, 45th International Congress of Pharmaceutical Sciences of the Federation of
International Pharmacists, Montreal, Canada, September, 1985; Proc. 45th Int. Congr.
Pharm. Sci., 1985, 80 (Abstract No. 106), p. 80.
74
19.
"Synthesis and In Vitro Evaluation of Two Sulfonium Salts Designed as Active SiteDirected Inhibitors of Phenylethanolamine-N-Methyltransferase", Samirah F. Hassan,
and Peter A. Crooks, 45th International Congress of Pharmaceutical Sciences of the
Federation of International Pharmacists, Montreal, Canada, September, 1985; Proc. 45th
Int. Congr. Pharm. Sci., 1985, 33 (Abstract No. 29), p. 33.
20.
"S-Acylation of Cysteine by Aspirin Anhydride - A Possible Mechanism for Aspirin
Hypersensitivity?" Hana Dannan, M.N. Khawam, Joseph B. Bogardus, Anwar A. Hussain,
and Peter A. Crooks, 39th National Meeting and Exposition of the Academy of
Pharmaceutical Sciences, American Pharmaceutical Association, Minneapolis,
Minnesota, October, 1985; Proc. Acad. Pharm. Sci., 1985, 15(2), 83 (Abstract No. 47).
21.
"Depletion of S-Adenosylhomocysteine Levels in Guinea Pig Lung After Chronic In Vivo
Exposure to S-(-)-Nicotine". C. Steven. Godin, Abdulghani A. Houdi, and Peter A.
Crooks, 39th National Meeting and Exposition of the Academy of Pharmaceutical
Sciences, American Pharmaceutical Association, Minneapolis, Minnesota, October,
1985; Proc. Acad. Pharm. Sci., 1985, 15(2) 122 (Abstract No. 6).
22.
"Stereospecific Synthesis and Structural Analysis, Using 1H-, 13C- and Auto-correlated 2Dimensional NMR Spectroscopy, of a Conformationally Defined, Rigid Analogue of
Dopa". Everett J. Horn, W. John Layton, Stanford L. Smith and Peter A. Crooks, 39th
National Meeting and Exposition of the Academy of Pharmaceutical Sciences, American
Pharmaceutical Association, Minneapolis, Minnesota, October, 1985; Proc. Acad. Pharm.
Sci., 1985, 15(2), 124 (Abstract No. 12).
23.
"Determination of Quaternary Ammonium Metabolites by Mass Spectrometric Analysis",
William F. Pool, Peter A. Crooks, Roger J. Greathead, and R. Parillo, Society of
Toxicology, Annual National Meeting, New Orleans, March, 1986; The Toxicologist, 1986,
6(1), 305 (Abstract No. 1026).
24.
"Quantitation of Polar Urinary Metabolites of Nicotine Enantiomers in the Guinea Pig",
Chukwuemeka G. Nwosu, C. Steven Godin, and
Peter A. Crooks, Society of
Toxicology, Annual National Meeting, New Orleans, March, 1986; The Toxicologist, 1986,
6(1), 249 (Abstract No. 1002).
25.
"N-Methyl-N'-Oxonicotinium Ion - a New Metabolite of R-(+)- Nicotine", William F. Pool,
and Peter A. Crooks, Society of Toxicology Annual National Meeting, New Orleans,
March, 1986; The Toxicologist, 1986, 6(1), 14 (Abstract No. 53).
26.
"Formation of MPP+ from 4-Phenylpyridine by Rabbit Tissue Cytosolic Preparations", C.
Steven Godin, and Peter A. Crooks, First National Meeting and Premiere Exposition of
the American Association of Pharmaceutical Scientists, Washington, DC, November,
1986; Pharm. Research, 1986, 3(5)(Supplement), 136S (Abstract 152).
27.
"Structural Analysis of N-Methyl-N'-Oxonicotinium Ion, a New Stereoselectively Formed
Metabolite of R-(+)-Nicotine in the Guinea Pig", William F. Pool, W. John Layton, and
Peter A. Crooks, First National Meeting and Premiere Exposition of the American
Assocation of Pharmaceutical Scientists, Washington, DC, November, 1986; Pharm.
Research, 1986, 3(5)(Supplement), 124S (Abstract 102).
75
28.
"Comparative Metabolism of Radiolabeled [3H-N'-CH3]-Nicotine Enantiomers in Rat and
Guinea Pig", Chukwuemeka G. Nwosu, Peter A. Crooks, First National Meeting and
Premiere Exposition of the American Association of Pharmaceutical Scientists,
Washington, DC, November, 1986; Pharm. Research, 1986, 3(5)(Supplement), 160S
(Abstract 248).
29.
"Synthesis of Novel 5'-Substituted-5'-deoxyadenosines Designed as Mechanism- Based
Enzyme Inhibitors", Samira F. Hassan, Peter A. Crooks, First National Meeting and
Premiere Exposition of the American Assocation of Pharmaceutical Scientists,
Washington, DC, November, 1986; Pharm. Research, 1986, 3(5)(Supplement), 22S
(Abstract 7).
30.
"Kinetics and Mechanism of Chlorination of Aliphatic Amino Acids by Chloramine-T",
Anwar A. Hussain, and Peter A. Crooks, First National Meeting and Premiere Exposition
of the American Assocation of Pharmaceutical Scientists, Washington, DC, November,
1986; Pharm. Research, 1986, 3(5)(Supplement), 62S (Abstract 92).
31.
"Mechanism of Decomposition of N-Chloro--Aliphatic Amino Acids", Riad Awad, Anwar
A. Hussain, and Peter A. Crooks, First National Meeting and Premiere Exposition of the
American Association of Pharmaceutical Scientists, Washington, DC, November, 1986;
Pharm. Research, 1986, 3(5)(Supplement), 66S (Abstract 108).
32.
"N-Chlorination of Diethylamine by Chloramine-T", Hana Dannan, Anwar A. Hussain, and
Peter A. Crooks, First National Meeting and Premiere Exposition of the American
Association of Pharmaceutical Scientists, Washington, DC, November, 1986; Pharm.
Research, 1986, 3(5)(Supplement), 68S (Abstract 104).
33.
"A Study of the Kinetics of the O to N Acyl Transfer of O-Acyl Derivatives of
Salicylamide", Fatima Tawfig, Anwar A. Hussain, and Peter A. Crooks, First National
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Washington, D.C., November, 1986; Pharm. Research, 1986, 3(5) (Supplement), 68S
(Abstract 116).
34.
"Species Differences in the In Vivo N-Methylation of Nicotine Enantiomers in the Guinea
Pig, Hamster, Rabbit and Rat", Chukwuemeka G. Nwosu, and Peter A. Crooks, Second
National Meeting and Exposition of the American Association of Pharmaceutical
Scientists, Boston, MA, June, 1987; Pharm. Research, 1987, 4(2)(Supplement), S-84
(Abstract P622).
35.
"Stability Studies on Two Cephalosporin Prodrugs", Akram Saab, Anwar A. Hussain,
James Truelove, and Peter A. Crooks, Second National Meeting and Exposition of the
American Association of Pharmaceutical Scientists, Boston, MA, June, 1987; Pharm.
Research, 1987, 4(2)(Supplement), S-57 (Abstract 490).
36.
"The Measurement of Plasma Nicotine Level by High Performance Liquid
Chromatography with Electrochemical Detection", Chen-Yie Chien, John N. Diana, and
Peter A. Crooks, Second National Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Boston, MA,June, 1987; Pharm. Research, 1987,
4(2)(Supplement), S-8 (Abstract 130).
76
37.
"Sulfonium Salts as Multisubstrate Adduct Inhibitors of Phenylethanolamine NMethyltransferase (PNMT)", Samira F. Hassan, and Peter A. Crooks, Second National
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Boston, MA, June, 1987; Pharm. Research, 1987, 4(2)(Supplement), S-20 (Abstract
P226).
38.
"Kinetic Studies on the N-Chlorination of Secondary Amines by Chloramine-T", Hana
Dannan, Anwar A. Hussain, and Peter A. Crooks, Second National Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Boston, MA, June
1987; Pharm. Research, 1987, 4(2)(Supplement), S-74 (Abstract P557).
39.
"In Vitro N'-Oxidation of Nicotine Enantiomers and R-(+)-N-Methylnicotinium Chloride by
Ziegler's Enzyme, Guinea Pig Liver Microsomes and Ram Seminal Vesicular
Microsomes", Peter A. Crooks, William .F. Pool, and Lyaquatali A. Damani, Second
National Meeting and Exposition of the American Association of Pharmaceutical
Scientists, Boston, MA, June 1987; Pharm. Research, 1987, 4(2)(Supplement), S-112
(Abstract P735).
40.
"Formation of Quaternary Amines by N-Methylation of Azaheterocycles with
Homogeneous Amine N-Methyltransferases", C. Steven Godin, Peter A. Crooks, and
Lyaquatali A. Damani, Second National Meeting and Exposition of the American
Association of Pharmaceutical Scientists, Boston, MA, June 1987; Pharm. Research,
1987, 4(2)(Supplement), S-112 (Abstract P736).
41.
"Metabolism of Nicotine Enantiomers by Isolated Guinea Pig Hepatocytes", C. Steven
Godin, Amanda J. Sherratt, William C. Lubawy, and Peter A. Crooks, Second National
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Boston, MA, June, 1987; Pharm. Research, 1987, 4(2)(Supplement), S-113 (Abstract
737).
42.
"Comparative Metabolism of [14C-2']-Nicotine in Mainstream and Sidestream Cigarette
Smoke", C. Steven Godin, Abdulghani A. Houdi, and Peter A. Crooks, Second National
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Boston, MA, June, 1987; Pharm. Research, 1987, 4(2)(Supplement), S-122 (Abstract
775).
43.
"Mechanism of Decomposition of Aliphatic N-Chloro-Alpha-Amino Acids", Riad Awad,
Anwar A. Hussain, Peter A. Crooks, and Lewis W. Dittert, Fourth International
Conference on Progress in Chemical Disinfection, Binghamton, New York, April, 1988,
Proc. 4th Int. Conf. Prog. Chem. Dis., Abstract No. 44, p. 46.
44.
"Kinetics and Mechanism of Chlorine Exchange Between Chloramine-T and Secondary
Amines", Hana Dannan, Anwar A. Hussain, Peter A. Crooks, and Lewis W. Dittert,
Fourth International Conference on Progress in Chemical Disinfection, Binghamton, New
York, April, 1988, Proc. 4th Int. Conf. Prog. Chem. Dis., Abstract No. 43, p. 45.
45.
"Kinetics and Mechanism of the Reactions of Hypochlorous Acid and Monochloramine
with N-Acetylcysteine", Prakash S. Kulkarni, Anwar A. Hussain, and Peter A. Crooks,
Fourth International Conference on Progress in Chemical Disinfection, Binghamton, New
York, April 1988, Proc. 4th Int. Conf. Prog. Chem. Dis., Abstract 41, p. 43.
77
46.
"N-Chloro Compounds - Their Chemistry, Kinetics and Possible Mechanism of Action",
Anwar A. Hussain, Peter A. Crooks, Lewis W. Dittert, Hana Dannan, Prakash S. Kulkani,
and Riad Awad, Fourth International Conference on Progress in Chemical Disinfection,
Binghamton, New York, April, 1988, Proc. 4th Int. Conf. Prog. Chem. Dis., Abstract No.
4, p. 5.
47.
"Retention of Radiolabel in the Male Reproductive Organs of the Guinea Pig after
Exposure to a 14C-Nicotine Metabolite", Panayiotis M. Zavos, William F. Pool, and Peter
A. Crooks, Meeting of the Association of South Eastern Biologists, Atlanta, GA, April,
1988.
48.
"Double Label Studies with R-(+)-[3H-N'-CH3;14C-N-CH3]-N-Methylnicotinium Acetate In
Vivo in the Guinea Pig", Panayiotis M. Zavos, William F. Pool, and Peter A. Crooks,
Meeting of the Association of South Eastern Biologists, Atlanta, GA, April, 1988.
49.
"Effects of Nicotine on Plasma Arginine Vasopressin in Normal Humans", Steven R.
Goldsmith, Donna Dodge-Brown, Adriana Katz, and Peter A. Crooks, National Meeting of
the American Federation for Clinical Research, April, 1988.
50.
"Differential Effect of Nicotine on Plasma Norepinephrine in Normal Humans and Patients
with Congestive Heart Failure", Steven R. Goldsmith, Donna Dodge-Brown, Adriana
Katz, Peter A. Crooks, National Meeting of the American Federation for Clinical
Research, April, 1988.
51.
"Metabolic Rates and Processes in the Lung", Peter A. Crooks,
Respiratory Drug Delivery, Lexington, KY, USA, May, 1988.
52.
"Sulphonium Salts", Peter A. Crooks, Invited Research Paper, Proceedings of the First
International Symposium on Sulphur Xenobiochemistry, King's College, London, UK,
September, 1988.
53.
"5'-Thioadenosine Derivatives as Potent and Selective Inhibitors of Histamine NMethyltransferase", Peter A. Crooks, Samira F. Hassan, Eric Benghiat, Susan K.
Hemrick-Luecke, and Raymond W. Fuller, Proceedings of the First International
Symposium on Sulphur Xenobiochemistry, King's College, London, UK, September,
1988.
54.
"Preliminary Studies on the Metabolism and Disposition of 14C-ADD 17014, A Novel
Triazoline Anticonvulsant in the Rat", Terence T. Tita, Pankaja K. Kadaba, and Peter A.
Crooks, Third National Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Orlando, Florida, November,1988; Pharm. Research, 1988, 5
(10) (Supplement), S-212, Abstract pp-1455.
55.
"Pharmacology of 2-Aminobenzonorbornenes", Peter Burn, and Peter A. Crooks, Annual
National Meeting of the Australian Chemical Society, Canberra, Australia, January 1989.
56.
"The Role of Peptidases of the Nasal and Respiratory Tract in the Bioavailability of
Nasally Administered Peptides", Peter A. Crooks, Eighth Annual Robert S. Rozman
Memorial Symposium, Drug Metabolism Group, Fort Washington, PA, June 1989.
Symposium on
78
57.
"Lung Peptidases and Their Activities", Peter A. Crooks, Second International
Symposium on Respiratory Drug Delivery, Keystone, Colorado, USA, March, 1990.
58.
"Novel Deoxyoligonucleotides Containing a Sulfonyl Link", Peter A. Crooks, Joseph A.
Maddry, Robert C. Reynolds, John A. Secrist III, and John A. Montgomery, Proceedings
of the First International Conference on Nucleic Acid Therapeutics, International Union of
Biochemistry, Tampa, Florida, January 1991.
59.
"Synthesis of Sulfonyl-Based Oligonucleotide Analogs", Joseph A. Maddry, Robert C.
Reynolds, Peter A. Crooks, John A. Secrist III, and John A. Montgomery, Proceedings of
the International Union of Biochemistry, Conference on Nucleic Acid Therapeutics,
Clearwater Beach, Florida, January, 1991, p. 74.
60.
"Synthesis of Oligonucleotide Analogs Containing Sulfonate Ester and Sulfonamide
Internucleoside Linkages", Joseph A. Maddry, Peter A. Crooks, Robert C. Reynolds,
John A. Secrist III, and John A. Montgomery, Proceedings of the 201st. National
Meeting of The American Chemical Society, Division of Medicinal Chemistry, Atlanta,
Georgia, April, 1991; Abstract MEDI-101.
61.
"Preparation and Utility of Nucleoside Sultones", Peter A. Crooks, Robert C. Reynolds,
Joseph A. Maddry, Anita Rathore, John A. Secrist III, and John A. Montgomery,
Proceedings of the 201st. National Meeting of The American Chemical Society, Division
of Medicinal Chemistry, Atlanta, Georgia, April, 1991; Abstract MEDI-102.
62.
"Synthesis and Hydrolytic Behavior of the O-Sulfate Conjugate of Salicylamide", Santosh
G. Kottayil, D. Allan Butterfield, Anwar A. Hussain, and Peter A. Crooks, Proceedings of
the Joint Central-Great Lakes Regional Meeting of the American Chemical
Society,Division of Medicinal Chemistry, Indianapolis, Indiana, May, 1991; Abstract,
MEDI-18.
63.
"Synthesis, Characterization and Relative Analgesic Potencies of the 6-O-Sulfate
Conjugates of Some 3-Substituted Morphine, Dihydromorphine and N-Methylmorphinium
Analogs", Santosh G. Kottayil, Abdulghani A. Houdi, D. Allan Butterfield, and Peter A.
Crooks, Proceedings of the 202nd National Meeting of The American Chemical Society,
Division of Medicinal Chemistry, New York NY, August, 1991;Abstract MEDI-149.
64.
"Nicotine Metabolites Alter Dopamine Uptake and Release in Striatum In Vitro". Laura
Leibee, Peter A. Crooks, Susan T. Buxton, Ann L. Jewell, and Linda P. Dwoskin, Annual
National Meeting of the Society for Neuroscience, New Orleans, Louisiana, November,
1991; Soc. Neurosci. Abstr., 1991, 17, 1076.
65.
"Synthesis and Characterization of N-(-D-Glucuronopyranosyl)-S-(-)-Cotininium Uronate
Inner Salt". William S. Caldwell, Gary D. Byrd, K.-M. Chang, M.S. Uhrig, J. Donald
deBethizy, Balwinder S. Bhatti, Robert M. Riggs, and Peter A. Crooks, Proceedings of
the 45th Tobacco Chemistsí Research Conference, Ashville, North Carolina, October,
1991, Abstract 31.
66.
"Characterization of the Glucuronide Conjugate of Cotinine: A Previously Unidentified
Major Metabolite of Nicotine in Smokers Urine". William S. Caldwell, Gary D. Byrd, K.-M.
79
Chang, M.S. Uhrig, J. Donald deBethizy, Balwinder S. Bhatti, Robert M. Riggs, and Peter
A. Crooks, Proceedings of the South East Regional Meeting of the American Chemical
Society, Division of Medicinal Chemistry, Richmond, VA, November, l991.
67.
"[N-(-D-Glucuronopyranosyl)-(S)-(-)-Cotininium] Uronate Inner Salt: A New Major
Metabolite of Nicotine in Smokers' Urine". Jackie M. Greene, Gary D. Byrd, William S.
Caldwell, K.-M. Chang, M.S. Uhrig, J.Donald deBethizy, Balwinder S. Bhatti, Robert M.
Riggs, and Peter A. Crooks, Proceedings of the 45th Tobacco Chemists' Research
Conference, Ashville, North Carolina, October, 1991, Abstract 32.
68.
"Characterization and Analgesic Activity of 3-O-Acyl Derivatives of Morphine 6-OSulfate", Santosh A. Kottayil, Abdulghani A. Houdi, Bin Sun, D. Allan Butterfield, and
Peter A. Crooks, Proceedings of the 24th Central Regional Meeting of the American
Chemical Society, Cincinnati, OH, May, 1992.
69.
"Comparative Pharmacological Effects of Drugs and Their O-Sulfate Conjugates",
Abdulghani A. Houdi, Santosh G. Kottayil, D. Allan Butterfield, M. Lu, Anwar A. Hussain,
and Peter A. Crooks, Proceedings of the 24th Central Regional Meeting of the American
Chemical Society, Cincinnati, OH, May, 1992.
70.
"Formation of a Novel 5,6-Dihydro-1,4-Oxazino Nucleoside", Robert M. Riggs, and Peter
A. Crooks, Proceedings of the 24th Central Regional Meeting of the American Chemical
Society, Cincinnati, OH, May 1992.
71.
"N-Oxidation, N-Methylation and N-Conjugation Reactions of Nicotine", Peter A. Crooks,
Proceedings of the International Union of Toxicology (IUTOX), Satellite Meeting on the
Absorption, Distribution, Metabolism and Excretion of Nicotine and Related Alkaloids,
Salsomaggiore Terme, Italy, June, 1992 (Abstract I4).
72.
"Oxidative Metabolism of Nicotine Enantiomers in Isolated Guinea Pig Hepatocytes".
Peter A. Crooks, Amanda J. Sherrat, and C Steven Godin, Proceedings of the
International Union of Toxicology (IUTOX), Satellite Meeting on Absorption, Distribution,
Metabolism and Excretion of Nicotine and Related Alkaloids, Salsomaggiore Terme, Italy,
June, 1992 (Abstract P6).
73.
"Evidence for Urinary Excretion of Glucuronide Conjugates of Nicotine, Cotinine and
Trans-3'-hydroxycotinine in Smokers", Gary D. Byrd. William S. Caldwell, K.-M. Chang,
Jackie M. Greene, J. Donald deBethizy, Peter A. Crooks, Balwinder S. Bhatti, and Robert
M. Riggs, Proceedings of the International Union of Toxicology (IUTOX), Satellite
Meeting on Absorption, Distribution, Metabolism and Excretion of Nicotine and Related
Alkaloids, Salsomaggiore Terme, Italy, June, 1992 (Abstract 04).
74.
"Cotinine Glucuronide, A Major Urinary Metabolite in Smokers", Gary D. Byrd, William S.
Caldwell, M.S. Uhrig, Jackie M. Greene, K.-M. Chang, J. Donald deBethizy, Peter A.
Crooks, Balwinder S. Bhatti, and Robert M. Riggs, Proceedings of the 40th American
Society of Mass Spectrometry Conference on Mass Spectrometry and Allied Topics,
Washington, DC, June, 1992.
75.
"Potent Central Activity of Morphine-6-0-Sulfate and Morphine 3-O-Acetyl-6-O-Sulfate",
Abdulghani A. Houdi, Santosh G. Kottayil, D. Allan Butterfield, and Peter A. Crooks, 7th
Annual Meeting and Exposition of the American Association of Pharmaceutical
80
Scientists, November, 1992, San Antonio, Texas; Pharm. Research, 1992, 9 (10)
(Supplement), Abstract MNPC 5015.
76.
"Blood-Brain Barrier Integrity During In Vivo Microdialysis as Determined by 4Trimethylammonium Antipyrine, a Charged Non-Radionuclide Antipyrine Derivative",
David D. Allen, Peter A. Crooks, and Robert A. Yokel, 7th Annual Meeting and Exposition
of the American Association of Pharmaceutical Scientists, November, 1992, San Antonio,
Texas; Pharm. Research, 1992, 9, (10) (Supplement), Abstract PPDM 8354.
77.
"Nornicotine-Induced Dopamine Release from Rat Striatal Slices is ConcentrationDependent, Calcium-Dependent and Stereoselective", Linda P. Dwoskin, Susan T.
Buxton, Li Hong Teng, and Peter A. Crooks, Proceedings of the College on the Problems
of Drug Dependency, Annual Meeting, June, 1993, Toronto, Canada; Comm. Problems
on Drug Dependence, 1993, 55, 11.
78.
"Is the Stereoselectivity of Nicotine-Induced Dopamine Release Dependent Upon the
Presynaptic Dopamine Accessed?" Linda P. Dwoskin, Li Hong Teng, Susan T. Buxton,
and Peter A. Crooks, Gordon Research Conference on Catecholamines, July 25-30,
1993, Andover, New Hampshire, USA.
79.
"Stereoselectivity of Nicotine to Induce Dopamine Release from Superfused Rat Striatal
Slices: Dependence upon Prior Dopamine Loading", Li Hong Teng, Susan T. Buxton,
Peter A. Crooks, and Linda P. Dwoskin, Society for Neuroscience Annual National
Meeting, November, 1993, Washington, D.C., Soc. Neurosci. Abstr., 1993, 19, 932.
80.
"Nornicotine and Other Minor Tobacco Alkaloids Release [3H] Dopamine from
Superfused Rat Striatal Slices", Peter A. Crooks, Alain Ravard, Niranjan Deo, Li Hong
Teng, and Linda P. Dwoskin, 8th Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, November, 1993, Orlando, Florida; Pharm.
Research, 1993, 10 (10) (Supplement),
81.
"Novel Prodrugs of Indomethacin: Synthesis and Stability Studies", Robert M. Riggs,
Shyamala Chandrasekaran, Paul Ashton, and Peter A. Crooks, 8th Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 1993,
Orlando, Florida; Pharm. Research, 1993, 10 (10) (Supplement),
82.
"The Effect of Surface Active Agents on the Stability of Aspartame". Anwar A. Hussain,
Jonan Jona, and Peter A. Crooks, 8th Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, November, 1993, Orlando, Florida; Pharm.
Research, 1993, 10 (10) ( Supplement),
83.
"Kinetics and Mechanism of the Reaction of Chloramine-T with Model Amino Acids",
Anwar A. Hussain, Peter A. Crooks, Lewis Dittert, Riad Awad, and Jonan Jona, 8th
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 1993, Orlando, Florida; Pharm. Research, 1993, 10 (10)
(Supplement),
84.
"Utilization of Prodrugs to Enhance the Transdermal Absorption of Indomethacin". Jonan
Jona, Peter A. Crooks, Lewis Dittert, and Anwar A. Hussain, 8th Annual Meeting and
81
Exposition of the American Association of Pharmaceutical Scientists, November, 1993,
Orlando, Florida; Pharm. Research, 1993, 10 (10) (Supplement),
85.
"A Rational Approach to the Design of an Effective Chlorine-Based Disinfectant for the
Treatment of Water" Anwar A. Hussain, and Peter A. Crooks, Kentucky Water
Resources Symposium, December, 1993, Lexington, Kentucky.
86.
"Disease Enhanced Co-Delivery of Acyclovir and Flubiprofen from a Biodegradable
Sustained Release Device." Hong Guo, Tadeusz Cynkowski, Grazyna Cynkowska,
Robert M. Riggs, Peter A. Crooks, and Paul Ashton, Annual Meeting of the Association
for Research in Vision and Ophthalmology, May, 1994, Sarasota, Florida, Invest.
Ophthalmol. Vis. Sci., 1994, 35/4, 1906, Abstract #3020.
87.
"CoDrugs in the Prevention of Posterior Capsular Opacification." C.W. Anderson, John
D. Conklin, J.R. Bierly, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs,
Peter A. Crooks, and Paul Ashton, Proceedings of the Annual Meeting of the Association
for Research in Vision and Ophthalmology, May, 1994, Sarasota, Florida, Invest.
Ophthalmol. Vis. Sci., 1994, 35/4, 1934, Abstract #3139-29.
88.
"Bioerodible Sustained Release Subconjunctival Co-Delivery of Triamcinolone Acetonide
and 5-Fluorouracil". D.L. Blandford, M. Huffman, Tadeusz Cynkowski, Grazyna
Cynkowska, Robert M. Riggs, Peter A. Crooks, and Paul Ashton, Proceedings of the
Annual Meeting of the Association for Research in Vision and Ophthalmology, May,
1994, Sarasota, Florida, Invest. Ophthalmol. Vis. Sci., 1994, 35/4, 1430, Abstract #81370.
89.
"Determination of Vitreous Elimination Kinetics of an Antineovascular Steroid by HPLC".
Michelle Howard, D.L. Blandford, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M.
Riggs, Peter A. Crooks, and Paul Ashton, Proceedings of the Annual Meeting of the
Association for Research in Vision and Ophthalmology, May, 1994, Sarasota, Florida,
Invest. Ophthalmol. Vis. Sci., 1994, 3514, 2216, Abstract #4457-9.
90.
"Lobeline Robustly Increases Tritiated Dopamine Release From Rat Striatal Slices".
Linda P. Dwoskin, Li Hong Teng, Susan T. Buxton, and Peter A. Crooks, College on
Problems of Drug Dependency, Annual Meeting, June 18-23, 1994, Palm, Beach,
Florida, Comm. Problems Drug Dependence, 1994, 56, 36.
91.
"Direct Determination of Nicotine N-Glucuronide in Human Biological Samples", Gary D.
Byrd, William S. Caldwell, Peter A. Crooks, Alain Ravard, and Balwinder S. Bhatti, Proc.
International Symposium on Nicotine - The Effects of Nicotine on Biological Systems II,
Satellite Symposium of the XIIth International Congress of Pharmacology, July, 1994,
Montreal, Canada. p. 131.
92.
"Detection of a Long-Lived Nicotine Metabolite in Rat Brain Following Peripheral Nicotine
Administration", Peter A. Crooks, Min Li, and Linda P. Dwoskin, Proc. International
Symposium on Nicotine - The Effects of Nicotine on Biological Systems II, Satellite
Symposium of the XIIth International Congress of Pharmacology, July, 1994, Montreal,
Canada, p. 126.
82
93.
"N-Substituted Nicotine Analogs, A New Class of Nicotinic Receptor Antagonist", Li Hong
Teng, Alain Ravard, Susan T. Buxton, Peter A. Crooks, and Linda P. Dwoskin, Proc.
International Symposium on Nicotine - The Effects of Nicotine on Biological Systems II,
Satellite Symposium of the XIIth International Congress of Pharmacology, July, 1994,
Montreal, Canada, p. 19.
94.
"Lobeline Evokes a Marked Utilization of Dopamine in Rat Striatum". Linda P. Dwoskin, Li
Hong Teng, and Peter A. Crooks, Proc. International Symposium on Nicotine - The
Effects of Nicotine on Biological Systems II, Satellite Symposium on the XIIth
International Congress of Pharmacology, July, 1994, Montreal, Canada, p. 64.
95.
"Locomotor and Motivational Effects of S-(-)-Nornicotine, a Nicotine Metabolite and Minor
Constituent of Tobacco". Linda P. Dwoskin, Peter A. Crooks, Melinda C. Bradley, and
Michael T. Bardo, XIIth International Congress of Pharmacology, Montreal, Canada, July
24-29, 1994; Can. J. Physiol. Pharmacol., 1994, 72, Suppl. 1, 363, Abstract No p.
13.7.19.
96.
"The Toxicity of Lobeline on Central Dopamine (DA) Neurons in the Rat". Li Hong Teng,
Susan T. Buxton, Peter A. Crooks, and Linda P. Dwoskin, Society of Toxicology, Annual
Meeting, March 1995, Baltimore, MD; The Toxicologist, 1995, 15, (1), p. 147.
97.
"Nornicotine, An Active Metabolite of Nicotine, is Detected in Brain Following Peripheral
Administration of S-(-)-Nicotine." Peter A. Crooks, Min Li, and Linda P. Dwoskin,
Proceedings of the Inaugural Scientific Conference of the Society for Research on
Nicotine and Tobacco, March, 1995, San Diego, California, Abstract P07.
98.
"Nornicotine,The Active Metabolite of Nicotine, Contributes to the Abuse Liability of
Tobacco Smoking." Linda P. Dwoskin, LiHong Teng, Alain Ravard, Peter A. Crooks,
Melinda C. Bradley, Michael T. Bardo, Proceedings of the Inaugural Scientific
Conference of the Society for Research on Nicotine and Tobacco, March, 1995, San
Diego, California, Abstract P06.
99.
"Novel Prodrugs of Ganciclovir for Oral Administration", Grazyna Cynkowska, Tadeusz
Cynkowski, Peter A. Crooks, Hong Guo, and Paul Ashton, Proceedings of the Annual
Meeting of the Association for Research in Vision and Ophthalmology, May, 1995, Fort
Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1995, 36/4, S180, Abstract 857.
100.
"Co-Administration of 5-FU with Angiostatic Steroids gives Synergistic Effects in a Rabbit
Model of Corneal Neovascularization", Michelle Howard, M. Bierly, Tadeusz Cynkowski,
Grazyna Cynkowska, Peter A. Crooks, and Paul Ashton, Proceedings of the Annual
Meeting of the Association for Research in Vision and Ophthalmology, May, 1995, Fort
Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1995, 36/4, S180, 5161, Abstract 789697.
101.
"The Use of Co-Drugs in the Prevention of Posterior Capsular Opacification Following
Cataract Surgery", R. J. Piccione, C.W. Anderson, Peter A. Crooks, Tadeusz Cynkowski,
Grazyna Cynkowska, Hong Guo, and Paul Ashton, Proceedings of the Annual Meeting of
the Association for Research in Vision and Ophthalmology, May, 1995, Fort Lauderdale,
Florida; Invest. Ophthalnol. Vis. Sci., 1995, 36/4, S797, Abstract 3690-677.
83
102.
"Increased Angiostatic Effects by Co-Administration of Steroids with 5- Fluorouracil",
Antonio Gagliardi, Michelle Howard, Tadeusz Cynkowski, Grazyna Cynkowska, Peter A.
Crooks, and Paul Ashton, Proceedings of the Annual Meeting of the Association for
Research in Vision and Ophthalmology, May, 1995, Fort Lauderdale, Florida; Invest.
Opthalmol. Vis. Sci., 1995, 36/4, S93, Abstract 453-361.
103.
"Sustained Device for Co-Administration of Suramin and Amiloride", Hong Guo, Tadeusz
Cynkowski, Grazyna Cynkowska, Peter A. Crooks, and Paul Ashton, Proceedings of the
Annual Meeting of the Association for Research in Vision and Ophthalmology, May,
1995, Fort Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1995, 36/4, S160, Abstract
779-687.
104.
"Safety and Pharmacokinetics of an Intravitreal Suspension of a Triamcinolone/5FU CoDrug", D. P. Hainsworth, S. Chen, A. S. Berger, Tadeusz Cynkowski, Grazyna
Cynkowska, Peter A. Crooks, and Paul Ashton, Proceedings of the Annual Meeting of
the Association for Research in Vision and Ophthalmology, May, 1995, Fort Lauderdale,
Florida; Invest. Ophthalmol. Vis. Sci., 1995, 36/4, S162, Abstract 7909-698.
105.
"5-FU Prodrug for the Treatment of Epithelial Downgrowth", J. R. Bierly, J. D. Brown, P.
Andrew Pearson, B. B. Mahan, Peter A. Crooks, Tadeusz Cynkowski, Grazyna
Cynkowska, Hong Guo, and Paul Ashton, Proceedings of the Annual Meeting of the
Association for Research in Vision and Ophthalmology, May, 1995, Fort Lauderdale,
Florida, Invest. Ophthalmol. Vis. Sci., 1995, 36/4, S85, Abstract 411-319.
106.
"Subconjunctival Sustained Release 5-Fluorouracil as an Adjunct Therapy for Molteno
Shunts", J. D. Brown, J. R. Bierly, J. C. Gross, E. T. Schmeiser, Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, Proceedings of
the Annual Meeting of the Association for Research in Vision and Ophthalmology, May,
1995, Fort Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1995, 36/4, Abstract 791699.
107.
"Development of L-Canavanine, L-Canaline and Their Synthetic Analogs as
Chemotherapeutic Agents for the Treatment of Pancreatic Cancer", Peter A. Crooks,
Supinan NaPhuket, J. William Freeman, and Gerald A. Rosenthal, Proceedings of the
209th National Meeting of the American Chemical Society, April, 1995, Anaheim, CA,
Abstract MEDI-055.
108.
"Unexpected Reaction in the Attempted Synthesis of a Drug-Amino Acid Ester
Conjugate", Peter A. Crooks, Grazyna Cynkowska, Paul Ashton, and Tadeusz
Cynkowski, Proceedings of the 209th National Meeting of the American Chemical
Society, April, 1995, Anaheim, CA, Abstract MEDI-223.
109.
"Synthesis and Properties of Novel Codrugs of 5-Fluorouracil with Antiinflamatory
Agents." Grazyna Cynkowska, Tadeusz Cynkowski, Hong Guo, Paul Ashton, and Peter
A. Crooks, Proceedings of the 209th National Meeting of the American Chemical Society,
April 1995, Anaheim, CA, Abstract MEDI-118.
110.
"Synthesis of Novel Prodrugs of Ganciclovir with Improved Oral Bioavailability." Tadeusz
Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton, and Peter A. Crooks,
84
Proceedings of the 209th National Meeting of the American Chemical Society, April 1995,
Anaheim, CA, Abstract MEDI-118.
111.
"Behavioral Sensitization to Nornicotine: Lack of Correlation with 3H-Nicotine Binding in
Rat Whole Brain." Linda P. Dwoskin, Lincoln H. Wilkins, Peter A. Crooks, Melinda C.
Bradley, Michael T. Bardo,
Proceedings of the College on Problems of Drug
Dependency, Annual Meeting, June, 1995, Scottsdale, Arizona; Comm. Problems Drug
Dependence, 1995, 57, 143.
112.
"Neurochemical Characterization of a New Class of Novel Nicotinic Receptor Antagonist."
Peter A. Crooks, Lincoln H. Wilkins, Li Hong Teng, Alain Ravard, and Linda P. Dwoskin,
Proceedings of the College on Problems of Drug Dependency, Annual Meeting, June,
1995, Scottsdale, Arizona; Comm. Problems Drug Dependence, 1995, 57, 137.
113.
"Comparative Cytotoxic Effects of Semisynthetic Analogs of the Natural Arginine
Antimetabolite L-Canavanine." V. Dhawan, C. Y. Ang, Diana S. Swaffar, Supinan
NaPhuket, Peter A. Crooks, and Gerald A. Rosenthal, Proceedings of the 36th Annual
Meeting of the American Society of Pharmacognosy, July, 1995, Oxford, Mississippi,
Abstract P-117.
114.
"Synthesis and Properties of Novel Prodrugs of Antiinflammatory Agents with
Polyethylene Glycols", Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul
Ashton, and Peter A. Crooks, Proceedings of the 210th American Chemical Society
National Meeting, Chicago, IL, August, 1995, Abstract MEDI-169.
115.
"A Simple and Convenient Synthesis of Minor Tobacco Alkaloids and Related
Compounds", Niranjan M. Deo, and Peter A. Crooks, Proceedings of the 210th
American Chemical Society National Meeting, Chicago, IL, August, 1995, Abstract MEDI169.
116.
"Chiral Purity Determination of Tobacco Alkaloids by 1H-NMR Spectroscopy in presence
of 1,1'-Binaphthyl-2,2'-diylphosphonic Acid (BNPPA)", Alain Ravard, Balwinder S. Bhatti,
and Peter A. Crooks, Proceedings of the 210th American Chemical Society National
Meeting, Chicago, IL, August, 1995, Abstract MEDI-170.
117.
"Synthesis and Sustained Delivery of Suramin-Amiloride Codrug", Grazyna Cynkowska,
Hong Guo, Paul Ashton, Peter A. Crooks, and Tadeusz Cynkowski, Proceedings of the
210th American Chemical Society National Meeting, Chicago, IL, August, 1995, Abstract
MEDI-237.
118.
"Sustained Release of an Angiostatic Steroid and 5-Fluorouracil From A Novel Codrug
Device", Michelle Howard, Grazyna Cynkowska, Tadeusz Cynkowski, Peter A. Crooks,
and Paul Ashton, Tenth Annual Meeting and Exposition of the American Academy of
Pharmaceutical Scientists, November, 1995, Miami Beach, Florida; Pharm. Research,
1995, 12 (9) (Supplement), S-227, Abstract PDD 7143.
119.
"Synthesis, Properties and Sustained Release Delivery Systems for a Novel Codrug of
5-Fluorouracil With Triamcinolone Acetonide". Tadeusz Cynkowski, Grazyna Cynkowska,
Robert M. Riggs, Hong Guo, Paul Ashton, and Peter A. Crooks, Tenth Annual Meeting
and Exposition of the American Academy of Pharmaceutical Scientists, November, 1995,
85
Miami Beach, Florida; Pharm. Research, 1995, 12 (9) (Supplement), S-227, Abstract
PDD 714-4.
120.
"Synthesis and Properties of Novel Antiglaucoma Prodrugs and Codrugs of Ethacrynic
Acid". Grazyna Cynkowska, Tadeusz Cynkowski, Hong Guo, Paul Ashton, and Peter A.
Crooks, Tenth Annual Meeting and Exposition of the American Academy of
Pharmaceutical Scientists, November, 1995, Miami Beach, Florida; Pharm. Research,
1995, 12 (9) (Supplement), S-229, Abstract PDD 7145.
121.
"Synthesis and In Vitro Evaluation of Potent Agonists for Muscle Type Nicotinic
Cholinergic Receptors". Peter A. Crooks, Niranjan M. Deo, Balwinder S. Bhatti, Alain
Ravard, Patrick M. Lippiello, William S. Caldwell, and Merouane Bencherif, Tenth Annual
Meeting and Exposition of the American Academy of Pharmaceutical Scientists,
November, 1995, Miami Beach, Florida; Pharm. Research, 1995, 12 (9) (Supplement), S125, Abstract MNPC 5009.
122.
"Synthesis of Ligands That Bind to and Activate High Affinity CNS Nicotinic Cholinergic
Receptors". Peter A. Crooks, Balwinder S. Bhatti, Niranjan M. Deo, Alain Ravard,
Merouane Bencherif, Patrick M. Lippiello, and William S. Caldwell, "Tenth Annual
Meeting and Exposition of the American Academy of Pharmaceutical Scientists,
November, 1995, Miami Beach, Florida; Pharm. Research, 1995, 12 (9) (Supplement), S125, Abstract MNPC 5010.
123.
"Synthesis of Conformationally Constrained Analogs of Melphalan as Substrates for the
Large Neutral Amino Acid Transporter (System L)". Jyothi R. Matharu, Peter A. Crooks,
and Quentin R. Smith, Tenth Annual Meeting and Exposition of the American Academy
of Pharmaceutical Scientists, November, 1995, Miami Beach, Florida; Pharm. Research,
1995, 12 (9) (Supplement), S-125, Abstract MNPC 5011.
124.
"Evaluation of Synthetic Analogs of L-Canavanine and L-Canaline as Chemotherapeutic
Agents for the Treatment of Pancreatic Cancer". Supinan R. NaPhuket, Latchner S.
Trifonov, J. William Freeman, Gerald A. Rosenthal, and Peter A. Crooks, Tenth Annual
Meeting and Exposition of the American Academy of Pharmaceutical Scientists,
November, 1995, Miami Beach, Florida; Pharm. Research, 1995, 12 (9) (Supplement),
S-127, Abstract MNPC 5020.
125.
"Enzyme Inhibition by L-Canaline and Related Compounds". David Worthen, D. Ratliff,
Gerald A. Rosenthal, Jack Olson, Latchner Trifonov, and Peter A. Crooks, Tenth Annual
Meeting and Exposition of the American Academy of Pharmaceutical Scientists,
November, 1995, Miami Beach, Florida; Pharm. Research, 1995, 12 (9) (Supplement),
S-128, Abstract MNPC 5021.
126.
"Evidence that Nornicotine Acts to Release Dopamine from Rat Striatal Slices by a
Nicotinic Receptor - Mediated Mechanism". LiHong Teng, Susan T. Buxton, Peter A.
Crooks, and Linda P. Dwoskin, Society for Neuroscience Annual National Meeting,
November 1995, San Diego, CA; Soc. Neurosci. Abstr., 1995, 21 (Part 2), p. 1331,
Abstract 526.10.
127.
"Nornicotine-evoked [3H]-Dopamine Release from Rat Striatal Slices: Desensitization of
the Response to Nornicotine after Prior Exposure to Nicotine". Linda P. Dwoskin, LiHong
86
Teng, Susan T. Buxton, and Peter A. Crooks, Society for Neuroscience Annual National
Meeting, November, 1995, San Diego, CA; Soc. Neurosci. Abstr., 1995, 21, (Part 2), p.
1331, Abstract 526.8.
128.
"Development of a Novel Class of Nicotinic Receptor Antagonist: Inhibition of Nicotineevoked Striatal Dopamine Release and the Electrophysiological Response of a Cloned
Nicotinic Receptor Subtype in Xenopus Oocytes". Peter A. Crooks, LiHong Teng, Alain
Ravard, Susan T. Buxton, Bruce N. Cohen, David D. Allen, and Linda P. Dwoskin,
Society for Neuroscience Annual National Meeting, November, 1995, San Diego, CA;
Soc. Neurosci. Abstr., 1995, 21 (Part 3), p. 1834, Abstract 721.7.
129.
"Development of a Novel Class of Nicotinic Receptor Antagonist: Displacement of [ 3H]Nicotine Binding from Rat Striatal Membranes". Lincoln H. Wilkins, Peter A. Crooks,
Alain Ravard, Robert A. Yokel, and Linda P. Dwoskin, Society for Neuroscience Annual
National Meeting, November, 1995, San Diego, CA; Soc. Neuro sci. Abstr., 1995, 21
(Part 3), p. 1834, Abstract 721.8.
130.
"Synthesis of Novel Codrugs of Prostaglandin F2 with -Adrenergic Receptor Blockers
for the Treatment of Ocular Diseases". Grazyna Cynkowska, Tadeusz Cynkowski, Hong
Guo, Paul Ashton, and Peter A. Crooks, Proceedings of the 211th National Meeting of
the American Chemical Society, March, 1996, New Orleans, LA, Abstract MDI-028.
131.
"Novel Prodrug Ester Forms of Hydroxyl-Containing Drugs. Mono- and Dicarboxylic Oxa
Acid Conjugates". Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton,
and Peter A. Crooks, Proceedings of the 211th National Meeting of the American
Chemical Society, March, 1996, New Orleans, LA, Abstract MEDI-029.
132.
"Computer-Derived Molecular Model of the Binding Site of the Large Neutral Amino Acid
Transporter (System L) of the Blood-Brain Barrier". Quentin R. Smith, M. Hokeri, Jyothi
Matharu, David D. Allen, and Peter A. Crooks, Proceedings of the Annual FASEB
Meeting, April, 1996, Washington, D.C., Abstract 1304.
133.
"Characterization of the Binding Site of the Blood-Brain Barrier (BBB) Choline (Ch)
Transporter". David D. Allen, Jyothi R. S. Matharu, Peter A. Crooks, and Quentin R.
Smith, Proceedings of the Annual FASEB Meeting, April, 1996, Washington, D.C.,
Abstract 3989, FASEB J, 1996, 10, A691.
134.
"Pharmacologic Inhibition of Experimental Proliferative Vitreoretinopathy (PVR) Using a
Triamcinolone/5-Fluorouracil Codrug Sustained Release Pellet", J. A. Khawly, D. C. S.
Yang, Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks, and Paul Ashton,
Proceedings of the Annual Meeting of the Association for Research in Vision and
Ophthalmology, April, 1996, Fort Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1996,
37/3, S196, Abstract 196.
135.
"Analysis of a Sustained Release Intravitreal Codrug Device of 5-FU and Tri-Hydroxy
Steroid", Michelle Howard, S. Capoor, Tadeusz Cynkowski, Grazyna Cynkowska, Peter
A. Crooks, and Paul Ashton; Proceedings of the Annual Meeting of the Association for
Research in Vision and Ophthalmology, April, 1996, Fort Lauderdale, Florida; Invest.
Ophthalmol., Vis. Sci., 1996, 37/3, S582, Abstract 2681-B526.
87
136.
"Detection of Adenosine In Vivo in Intraocular Fluids", Michelle Howard, R. Huerfel, S.
Capoor, H. Sen, Myron K. Jacobson, Peter A. Crooks, Paul Ashton, and Andrew
Pearson; Proceedings of the Annual Meeting of the Association for Research in Vision
and Ophthalmology, April, 1996, Fort Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci.,
1996, 37/3, S568, Abstract 3033.
137.
"A Unique Interaction Between Polyamine and MDR Transporters in Cultured Chinese
Hamster Cells Transfected with Mouse MDR-1 gene". Shewan M. Aziz, Kenneth Ain,
Clifford P. Tsuboi, Peter A. Crooks, and Michael P. Gosland. Proceedings of the
American Association for Cancer Research, April, 1996, Washington, D.C., Abstract #
239.
138.
"Cotinine Pharmacology: Brain Uptake and Metabolism, Effects on Dopamine Release
and Lack of Behavioral Sensitization after Chronic Administration to Rats." Peter A.
Crooks, Li Hong Teng, Min Li, Michael T. Bardo, and Linda .P. Dwoskin, Proceedings of
the College on Problems of Drug Dependency, Fifty Eighth Annual Scientific Meeting,
June, 1996, San Juan, Puerto Rico; Coll. Problems Drug Dependency, 1996, 58, 29.
139.
"Further Characterization of a Novel Class of Nicotinic Receptor Antagonist." Linda P.
Dwoskin, M. Imad Damaj, David D. Allen, Lincoln H. Wilkins, and Peter A. Crooks,
Proceedings of the College on Problems of Drug Dependency, Fifty Eighth Annual
Scientific Meeting, June, 1996, San Juan, Puerto Rico; Coll. Problems Drug
Dependence, 1996, 58, 37.
140.
"A Leguminous L-Arginine Isostere Modulates In Vitro Drug Sensitivity and PGPMediated Multi-Drug Resistance." David R. Worthen, Lynn Chien, Clifford P. Tsuboi,
Michael P. Gosland, and Peter A. Crooks, Proceedings of the 37th Annual Meeting of the
American Society of Pharmacognosy, University of California, Santa Cruz, CA, July
1996.
141.
"Modulation of In Vitro Drug Sensitivity and PGP - Mediated Drug Transport by the
Naturally-Occurring L-Arginine Analog L-Canavanine. David R. Worthen, Lynn Chien,
Clifford P. Tsuboi, Michael P. Gosland, and Peter A. Crooks, Proceedings of the 212th
Meeting of the American Chemical Society, Orlando, FL, August 24 - 28, 1996,
Toxicology Abstract #19.
142.
"Synthesis and Properties of Novel Lipophilic Prodrug Ester Derivatives of 5Fluorouracil". Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks, Hong Guo, M.
Wu, and Paul Ashton, Eleventh Annual Meeting and Exposition of the American
Academy of Pharmaceutical Scientists, October, 1996, Seattle, Washington; Pharm.
Research, 1996, 13, (9) (Supplement), S-271, Abstract PDD 7154.
143.
"The Synthesis and Evaluation of Polyspermine Conjugates as Multidrug Resistance
Modulators and Potential Antineoplastics", by David R. Worthen, Clifford P. Tsuboi,
Shewan M. Aziz, and Peter A. Crooks, Eleventh Annual Meeting and Exposition of the
American Academy of Pharmaceutical Scientists, October, 1996, Seattle, Washington;
Pharm. Research, 1996, 13 (9) (Supplement), S-143, Abstract MNPC 5017.
144.
"The Presence of the Polyamine Transport System is Necessary for the Activity of the
Multiple Drug Resistance Transporter Acquired by Either Selection or Transfection".
88
Peter A. Crooks, Clifford P. Tsuboi, Michael P. Gosland, Kenneth Ain, David R. Worthen,
and Shewan M. Aziz; Eleventh Annual Meeting and Exposition of the American Academy
of Pharmaceutical Scientists, October, 1996, Seattle, Washington; Pharm. Research,
1996, 13 (9) (Supplement), S-394, Abstract PPDM 8005.
145.
"A Novel Technique for Visualizing the Intracellular Localization and Distribution of
Transported Mono-fluorosceinated Polyamines in Cultured Smooth Muscle Cells (SMC)."
Shewan M. Aziz, Mustafa Yatin, David Lipke, David R. Worthen, and Peter A. Crooks;
Eleventh Annual Meeting and Exposition of the American Academy of Pharmaceutical
Scientists, October, 1996, Seattle, Washington; Pharm. Research, 1996, 13 (9)
(Supplement), S-464, Abstract PPDM 8288.
146.
"Novel Codrugs of 5-Fluorouracil with Fluocinolone Acetonide, Desoximetasone, and
Hydrocortisone-17-butyrate". Grazyna Cynkowska, Tadeusz Cynkowski, Hong Guo, M.
Wu, Peter A. Crooks, and Paul Ashton; Eleventh Annual Meeting and Exposition of the
American Academy of Pharmaceutical Scientists, October, 1996, Seattle, Washington;
Pharm. Research, 1996, 13 (9) (Supplement), S-235, Abstract PDD 7009.
147.
"14C-Uptake of L-Canavanine and Structure-Activity Studies of L-Canavanine Analogues
in MIA-PaCa-2 Cancer Cells." Supinan R. NaPhuket, Latchner S. Trifonov, Chongxi Yu,
J. William Freeman, Gerald A. Rosenthal, and Peter A. Crooks; Eleventh Annual Meeting
and Exposition of the American Academy of Pharmaceutical Scientists, October, 1996,
Seattle, Washington, Pharm. Research, 1996, 13 (9) (Supplement), S-147, Abstract
MNPC-5034.
148.
"Novel Melphalan Analogues as Substrates for the Large Neutral Amino Acid Transporter
(System L)." Jyothi R. Matharu, Peter A. Crooks, and Quentin R. Smith; Eleventh Annual
Meeting and Exposition of the American Academy of Pharmaceutical Scientists, October,
1996, Seattle, Washington; Pharm. Research, 1996, 13 (9) (Supplement), S-142,
Abstract MNPC 5016.
149.
"In Vivo Quantification of Adenosine in a Porcine Model of Retinal Ischemia." Michelle
Howard, H. Sen, H. R. Huerfel, S. Capoor, Peter A. Crooks, Paul Ashton, and Myron K.
Jacobson; Eleventh Annual Meeting and Exposition of the American Academy of
Pharmaceutical Scientists, October, 1996, Seattle, Washington; Pharm. Research, 1996,
13 (9) (Supplement), S-124, Abstract CS 3037.
150.
"Lobeline Potently Inhibits [3H]Dopamine ([3H]DA) Uptake into Rat Striatal Vesicles and
Synaptosomes, and Promotes [3H]DA Release from Striatal Vesicles and Slices."
LiHong Teng, Peter A. Crooks, Patricia K. Sonsalla, and Linda P. Dwoskin; Society for
Neuroscience Annual Meeting, November, Washington, DC, Soc. Neurosci. Abstr, 1996,
22, 259.
151.
"N-Octylnicotinium iodide (NONI), A Nicotinic Receptor Antagonist: Competitive
Displacement of [3H]Nicotine Binding from Rat Striatal Membranes and Brain RegionSpecific Displacement of [3H]Cytisine Binding." Lincoln H. Wilkins, Peter A. Crooks,
James R. Pauly, and Linda P. Dwoskin; Society for Neuroscience Annual Meeting,
November, Washington. DC, Soc. Neurosci. Abstr. 1996, 22, 260.
89
152.
"RJR-2429: A Nicotinic Agonist with Selectivity for Muscle Nicotinic Cholinergic
Receptors." Merouane Bencherif, Peter A. Crooks, S. Arrington, K. W. Fowler, M. E.
Lovette, L. Reeves, William S. Caldwell, and Patrick M. Lippiello, Society for
Neuroscience Annual Meeting, November, washington. DC, Soc. Neurosci. Abstr. 1996,
22.
153.
"Expression of 3 Nicotinic Receptor Subunit mRNA in PC12 Cells." Merouane
Bencherif, Peter A. Crooks, S. Arrington, K. W. Fowler, J. Kreiger, M. E. Lovette, L.
Reeves, William S. Caldwell, and Patrick M. Lippiello, Society for Neuroscience Annual
Meeting, November, Washington. DC, Soc. Neurosci. Abstr. 1996, 22.
154.
"Synthesis of Angiostatic Codrugs for Intraocular Neovascularization". Grazyna
Cynkowska, Peter A. Crooks, Michelle Howard, Hong Guo, and Paul Ashton;
Proceedings of the 213rd American Chemical Society National Meeting, April, 1997, San
Francisco,CA, Abstract MEDI-117.
155.
"Synthesis and Properties of Natural Prodrugs of Camptothecin with Short Chain
Polyethylene Glycols and Polyoxaacids". Tadeusz Cynkowski, Grazyna Cynkowska,
Peter A. Crooks, Hong Guo, and Paul Ashton; Proceedings of the 213rd American
Chemical Society National Meeting, April, 1997, San Francisco, CA, Abstract MEDI-118.
156.
"Smart" CoDrugs. Rapid Intravitreal Delivery of 5FU and Prolonged Delivery of Steroid
from the Same Erodible Device". Hong Guo, Tadeusz Cynkowski, Grazyna Cynkowska,
Peter A. Crooks, G.J. Jaffe, and Paul Ashton; Proceedings of the Annual Meeting of the
Association for Research in Vision and Ophthalmology, May, 1997, Fort Lauderdale,
Florida; Invest. Ophthalmol. Vis. Sci., 1997, 38/4, S146, Abstract 717.
157.
"Synthesis and Structure-Activity Relationships of Analogs of RJR-2403, A CNSSelective Nicotinic Agonist". William S. Caldwell, Merouane Bencherif, Balwinder S.
Bhatti, Niranjan M. Deo, Grayland P. Dobson, Gary M. Dull, Patrick M. Lippiello, M. E.
Lovette, Craig H. Miller, Alain Ravard, Jeffrey D. Schmitt, and Peter A. Crooks;
Proceedings of the IBC International Conference on Nicotinic Acetylcholine Receptors as
Pharmaceutical Targets, July 24-25, 1997, Washington, DC, Abstract 2.
158.
"Azabicyclo Nicotine Analogs: Potent Agonists At Nicotinic Acetylcholine Receptors".
Merouane Bencherif, Peter A. Crooks, Balwinder S. Bhatti, Niranjan M. Deo, William S.
Caldwell, Jeffrey D. Schmitt, M. E. Lovette, K. Fowler, L. Reeves, and Patrick M.
Lippiello; Proceedings of the IBC International Conference on Nicotinic Acetylcholine
Receptors as Pharmaceutical Targets, July 24-25, 1997, Washington DC, Abstract 3.
159.
"3-O-Acylmorphine-6-O-Sulfate Analogs: Potent, Centrally Acting Morphine Derivatives".
Peter A. Crooks, Proceedings of the 214th American Chemical Society National Meeting,
September, 1997, Las Vegas, NV, Abstract TOXI-5.
160.
"N-Decylnicotinium Iodide (NDNI) Inhibits Nicotine-Evoked 86Rubidium (86Rb) Efflux from
Rat Striatal Synaptosomes ". Lincoln H. Wilkins, James R. Pauly, Peter A. Crooks, and
Linda P. Dwoskin, Society for Neuroscience Annual Meeting, October 1997, New
Orleans, LA: Soc. Neurosci. Abstr., 1997, 23 (Part 2), p. 1198, Abstract 477.1.
90
161.
"Polyamines Regulate Nicotinic Receptor Function in Rat Striatum ". Linda P. Dwoskin,
Susan T. Buxton, and Peter A. Crooks; Society for Neuroscience Annual Meeting,
October, 1997, New Orleans, LA; Soc. Neurosci. Abstr., 1997, 23 (Part 1), p. 914,
Abstract 364.5.
162.
"A Simple and Sensitive High-Performance Liquid Chromatographic Method of Analysis
for Determination of Quinones and Related Compounds in the Oil of Nigella sativa Seed".
Omar A. Ghosheh, Abdulghani A. Houdi, and Peter A. Crooks, Annual Meeting and
Exposition of the American Academy of Pharmaceutical Scientists, November, 1997,
Boston, MA; Pharm. Research, 1997, 14 (11) (Supplement), S-378, Abstract 2505.
163.
"In Vitro Immunotoxicology of the Naturally Occurring L-Arginine Antimetabolite LCanavanine". David R. Worthen, Ryan T. Combs, William H. Fortune, Neil E. Kay, Peter
A. Crooks, and Mary M. Bartik, Annual Meeting and Exposition of the American Academy
of Pharmaceutical Scientists, November, 1997, Boston, MA; Pharm. Research, 1997, 14
(11) (Supplement), S-385, Abstract 2526.
164.
"An In Vitro Evaluation of the Antineoplastic Activity of Some Crude and Pure
Constituents of Blackseed, Nigella sativa". David R. Worthen, Omar A. Ghosheh, and
Peter A. Crooks, Annual Meeting and Exposition of the American Academy of
Pharmaceutical Scientists, November 1997, Boston, MA; Pharm. Research, 1997, 14
(11)(Supplement), S-386, Abstract 2527.
165.
"Effects of L-Canavanine and Structural Analogues of L-Canavanine on the Ability of the
Amino Acyl tRNA Synthetase Complex to Charge Arginyl tRNA" Aimee K. Bence, Elaine
L. Jacobson, Supinan R. NaPhuket, and Peter A. Crooks, Annual Meeting and Exposition
of the American Academy of Pharmaceutical Scientists, November, 1997, Boston, MA;
Pharm. Research, 1997, 14 (11), (Supplement), S-392, Abstract 2551.
166.
"The Codrugs of Cortico Steroids with 5-Fluorouracil: Synthesis, Stability, and Sustained
Release Delivery Systems". Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks,
Hong Guo, and Paul Ashton, Annual Meeting and Exposition of the American Academy
of Pharmaceutical Scientists, November, 1997, Boston, MA; Pharm. Research, 1997, 14
(11) (Supplement), S-524, Abstract 3175.
167.
"Synthesis and Properties of Biolabile Prodrugs and Antiinflammatory Agents with
Polyoxa Acids and Short Chain Polyethylene Glycols". Grazyna Cynkowska, Tadeusz
Cynkowski, Peter A. Crooks, Hong Guo, and Paul Ashton, Annual Meeting and
Exposition of the American Academy of Pharmaceutical Scientists, November, 1997,
Boston, MA; Pharm. Research, 1997, 14 (11) (Supplement), S-533, Abstract 3206.
168.
"Affinity of Indane and Benzonorbornene Analogs of the Antitumor Agent NAM for the
System-L1 Carrier". E. Chikhale, J. Oki, Jyothi R. Matheru, Peter A. Crooks and Quentin
R. Smith, Annual Meeting and Exposition of the American Academy of Pharmaceutical
Scientists, November, 1997, Boston, MA; Pharm. Research, 1997, 14 (11),
(Supplement), S-663, Abstract 4085.
169.
"Brain Delivery of L-Meta-Sarcolysin, a Melphalan Analog, via the Large Neutral Amino
Acid Transporter of the Blood-Brain Barrier". Quentin R. Smith, M. Hokari, and Peter A.
Crooks, Annual Meeting and Exposition of the American Academy of Pharmaceutical
91
Scientists, November 1997, Boston, MA; Pharm. Research, 1997, 14 (11) (Supplement),
S-664, Abstract 4089.
170.
"A Novel Enantioselectivie Synthesis of (R)-(+) and (S)-(-)-Nornicotine via Alkylation of a
Chiral Pinanone Ketimine Template". Jason Swango, Munawer Qureshi, and Peter A.
Crooks, Annual Meeting and Exposition of the American Academy of Pharmaceutical
Scientists, November, 1997, Boston, MA, Pharm. Research, 1997, 14 (11) (Supplement),
S-695, Abstract 4207.
171.
"Nornicotine Pretreatment Reduces Self-Administration of Nicotine in Rats". Thomas A.
Green, Joanne M. Valone, Linda P. Dwoskin, Peter A. Crooks, and Michael T. Bardo,
Mid-Western Psychological Association Meeting, May, 1998, Chicago, Ill, Abstract 70,
121, 1998.
172.
"Synthesis and Properties of Biolabile Prodrugs of Zidovudine with Polyoxa Acids and
short Chain Polyethylene Glycols." Grazyna Cynkowska, Tadeusz Cynkowski, Peter A.
Crooks, Hong Guo, and Paul Ashton, Proceedings of the 215th American Chemical
Society National Meeting, March 29-April 2,1998, Dallas, Texas, Abstract No. MEDI-036.
173.
"Esters of 2-(2-Aminoethoxy)ethanol as a Novel Highly Biolabile Prodrug Type for
Carboxylic Acid and Hydroxyl-Containing Drugs." Tadeuz Cynkowski, Grazyna
Cynkowska, Peter A. Crooks, Hong Guo, and Paul Ashton, Proceedings of the 215th
National American Chemical Society Meeting, March 29-April 2, 1998, Dallas, Texas,
Abstract No. MEDI-083.
174.
"Codrug for the Treatment of Ocular Neovascularization." Michelle Howard, Peter A.
Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, and Paul Ashton, Proceedings of the
Annual Meeting of the Association for Research in Vision and Ophthalmology, May,
1998, Fort Lauderdale, Florida; Invest. Ophthalmol. Vis. Sci., 1998, 39/4, B562, Abstract
2705.
175.
"Synthesis and Structure-Activity Relationships of Analogs of RJR-2403, a CNS-Selective
Nicotinic Agonist." William S. Caldwell, Merouane Bencherif, Balwinder S. Bhatti,
Niranjan M. Deo, Grayland P. Dobson, Gary M. Dull, Patrick M. Lippiello, M. E. Lovette,
Craig H. Miller, Alain Ravard, Jeffrey D. Schmitt, and Peter A. Crooks, Fifth International
Geneva/Springfield Symposium on Advances in Alzheimer’s Therapy, April, 1998,
Geneva, Abtract No. 23.
176.
"Interactions of Lobeline and Nicotine with Amphetamine: In Vitro DA Release and
Drug Discrimination in Rats." Linda P. Dwoskin, Jane B. Acri, Peter A. Crooks, LiHong
Teng, and Jeffrey M. Witkin, Proceedings of the College on Problems of Drug
Dependency, Sixtieth Annual Scientific Meeting, June, 1998, Scottsdale, Arizona; Coll.
Problems Drug Dependency, 1998, 60, 37.
177.
"Increased Concentrations of Plasma Cotinine in Schizophrenic Smokers Compared
to Normal smokers." Peter A. Crooks, Omar Ghosheh, Linda P. Dwoskin, Thea
Rogers, and Jose de Leon, Proceedings of the College on Problems of Drug
Dependency, Sixtieth Annual Scientific Meeting, June, 1998, Scottsdale, Arizona; Coll.
Problems Drug Dependency, 1998, 60, 29.
92
178.
"Synthesis and Structure-Activity Relationships of Analogs of RJR-2403, A CNSSelective Nicotinic Agonist." Gary M. Dull, Merouane Bencherif, Balwinder S. Bhatti,
Niranjan M. Deo, Grayland P. Dobson, Patrick M. Lippiello, Craig H. Miller, Alain
Ravard, Jeffrey D. Schmitt, Peter A. Crooks, and William S. Caldwell, Proceedings of
the 216th American Chemical Society National Meeting, August 23-27, 1998, Boston,
MA, Abstract No. MEDI-143.
179.
"Synthesis and Structure-Activity Relationships of Analogs of 2-(3-Pyridyl)-1azabicyclo[2.2.2]octane, RJR-2429, A Selective Ligand at Nicotinic Acetylcholine
Receptors". Peter A. Crooks, Balwinder S. Bhatti, Niranjan M. Deo, Jeffrey D. Schmitt,
Merouane Bencherif, and William S. Caldwell, Proceedings of the 216th American
Chemical Society National Meeting, August 23-27, 1998, Boston, MA, Abstract No.
MEDI-144.
180.
"Synthesis of Strusturally Related Lobelia inflata Alkaloids and Lobeline Analogs." Marlon
D. Jones, Muhammad M. Qureshi, Linda P. Dwoskin, and Peter A. Crooks, Proceedings
of the 216th American Chemical Society National Meeting, August 23-27, 1998, Boston,
MA, Abstract No. MEDI-152.
181.
"2-(Pyridyl)-1-azatricyclo[3.3.1.13,7]decane, RJR-2531, A Potent Antagonist at the
Nicotinic Acetylcholine Receptor." Balwinder S. Bhatti, Jeffrey D. Schmitt, Niranjan M.
Deo, Merouane Bencherif, Peter A. Crooks, and William S. Caldwell, Proceedings of the
216th American Chemical Society National Meeting, August 23-27, 1998, Boston, MA,
Abstract No. MEDI-154.
182.
"Synthesis and Properties of Novel Prodrugs of Saquinavir with Short Chain Polyethylene
Glycols, Polyoxa Acids and Amino Acids." Tadeusz Cynkowski, Grazyna Cynkowska,
Peter A. Crooks, Hong Guo, and Paul Ashton, Proceedings of the 216th American
Chemical Society National Meeting, August 23-27,1998, Boston, MA, Abstract No. MEDI346.
183.
"Synthesis and Properties of Biolabile Prodrugs of Didanosine with polyoxa Acids, Amino
Acids and Short Chain Polyethylene Glycols." Grazyna Cynkowska, Tadeusz Cynkowski,
Peter A. Crooks, Hong Guo, and Paul Ashton, Proceedings of the 216th American
Chemical Society National Meeting, August 23-27,1998, Boston, MA, Abstract No. MEDI347.
184.
"N-n-Octylnicotinium Iodide (NONI) Selectively Inhibits [3H]-Epibatidine ([3H]EPI) Binding:
Quantitative Autoradiographic Analysis". Lincoln H. Wilkins, James R. Pauly, Peter A.
Crooks, and Linda P. Dwoskin, Society for Neuroscience Annual Meeting, November,
1998, Los Angeles, CA: Soc. Neurosci. Abstr., 1998, 24,(part 1), p87, Abstract 39.21.
185.
"Robust and Protracted Sensitization to the Locomotor Effects of Intermittent Nicotine
Administration ". Linda P. Dwoskin, Lincoln H. Wilkins, T.P. Toller, Michael T. Bardo,
and Peter A. Crooks, Society for Neuroscience Annual Meeting, November, 1998, Los
Angeles, CA: Soc. Neurosci. Abstr., 1998, 24,(part 1), p338, Abstract 134.19.
186.
"Nornicotine is Self-Administered Intravenously and Reduces Nicotine SelfAdministration in Rats". Michael T. Bardo, Thomas A. Green, J. M. Valone, Peter A.
93
Crooks, and Linda P. Dwoskin, Society for Neuroscience Annual Meeting, November,
1998, Los Angeles, CA: Soc. Neurosci. Abstr., 1998, 24,(part 1), p752, Abstract 294.12.
187.
"Synthesis and Evaluation of Hydrolysis Kinetics for Two Novel Angiostatic Codrugs".
Michelle Howard, Grazyna Cynkowska, Tadeusz Cynkowski, Andrew P. Pearson, Peter
A. Crooks, and Paul Ashton, Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, November, 1998, San Francisco, CA, PharmSci
(Supplement), 1998, 1(1), p. S-194, Abstract 2190.
188.
"Synthesis and Properties of Novel Codrugs of Ritonavir with Oxa Acids, Amino Acids,
and Aminooxa Acids". Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks, Hong
Guo, and Paul Ashton, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 1998, San Francisco, CA, PharmSci
(Supplement), 1998, 1(1), p. S-429, Abstract 3229.
189.
"Synthesis and Properties of Biolabile Prodrugs of Anticancer, Antiviral and
Antiinflammatory with Agents Aminooxa Acids". Grazyna Cynkowska, Tadeusz
Cynkowski, Peter A. Crooks, Hong Guo, and Paul Ashton, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 1998,
San Francisco, CA, PharmSci (Supplement), 1998, 1(1), p. S-430, Abstract 3230.
190.
"Synthesis of L-Indospicine and Analogs of L-Indospicine for Use as Potential
Therapeutic Agents. " Aimee K. Bence, and Peter A. Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 1998,
San Francisco, CA, PharmSci (Supplement), 1998, 1(1), p. S-555, Abstract 3675.
191.
"Synthesis of Stereochemically Defined Lobeline Analogs as Potential CNS Agents".
Marlon D. Jones, Muhammed M. Qureshi, Linda P. Dwoskin, and Peter A. Crooks,
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 1998, San Francisco, CA, PharmSci (Supplement), 1998, 1(1), p.
S-556, Abstract 3681.
192.
"A Novel Enantioselective Synthesis of R-(+)- and S-(-)-Anabasine via Alkylation of a
Chiral Hydroxypinanone Ketimine Template". Marlon D. Jones, Muhammed M.
Qureshi, and Peter A. Crooks, Annual Meeting and Exposition of the American
Association of
Pharmaceutical Scientists, November, 1998, San Francisco, CA,
PharmSci (Supplement), 1998, 1(1), p. S-556, Abstract 3682.
193.
"An HPLC Method for the Quantitation of Caffeine, and Major Nicotine Metabolites in
Human Plasma Samples". Omar H. Ghosheh, Jose de Leon, Thea Rogers, Linda P.
Dwoskin, and Peter A. Crooks, Annual Meeting and Exposition of the American
Association of
Pharmaceutical Scientists, November, 1998, San Francisco, CA,
PharmSci (Supplement),1998,1(1), p. S-574, Abstract 3740.
194.
"Structure-Activity Study of Novel Anti-HIV Prodrugs of Zalcitabine with Acids, oxa
Acids and Aminooxa Acid Derivatives". Grazyna Cynkowska, Tadeusz Cynkowsi, Peter
A. Crooks, Hong Guo, and Paul Ashton, Proceedings of the 217th American Chemical
Society National Meeting, March 21-25,1999, Anaheim, CA, Abstract No. MEDI 170.
94
195.
"Synthesis and Properties of Novel Codrugs of Protease Inhibitors with Reverse
Transcriptase Inhibitors". Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks,
Hong Guo, and Paul Ashton, Proceedings of the 217th American Chemical Society
National Meeting, March 21-25,1999, Anaheim, CA, Abstract No. MEDI 171.
196.
"N-Alkylated Pyridine Analogs: Potent and Selective Antagonists at Nicotinic
Acetylcholine Receptors". Joshua T. Ayers, Aaron J. Haubner, Lincoln H. Wilkins,
Vladimir P. Grinevich, Omar H. Ghosheh, Linda P. Dwoskin and Peter A. Crooks;
Proceedings of the 2nd IBC International Conference on Nicotinic Acetylcholine
Receptors: Advances in Molecular Pharmacology and Drug Development, May 1314,1999, Annapolis, MD, Abstract 7.
197.
“Stereochemically Defined Lobeline Analogues: Inhibition of [3H]Dopamine Uptake and
[3H]Nicotine Binding in Rat Striatum.” Peter A. Crooks, Marlon D. Jones, M. Dathan
Chesnut, A. M. Jaromczyck, and Linda P. Dwoskin, Proceedings of the College on
Problems of Drug Dependence, Sixty First Annual Scientific Meeting, June, 1999,
Acapulco, Mexico; Coll. Problems Drug Dependence, 1999, 61, 29.
198.
“Nornicotine Evokes [3H] Overflow from Rat Nucleus Acumbens Slices Preloaded with
[3H]Dopamine.” Thomas A. Green, Michael T. Bardo, Peter A. Crooks, Aaron J. Haubner,
and Linda P. Dwoskin, Proceedings of the College on Problems of Drug Dependence,
Sixty First Annual Scientific Meeting, June, 1999, Acapulco, Mexico; Coll. Problems Drug
Dependence, 1999, 61, 54.
199.
“Lobeline Decreases Amphetamine and Methamphetamine Self-Administration in Rats.”
Jennifer E. Klebaur, E. R. Neiman, S. B. Philips, Michael T. Bardo, Peter A. Crooks, and
Linda P. Dwoskin, Proceedings of the College on Problems of Drug Dependence, Sixty
First Annual Scientific Meeting, June, 1999, Acapulco, Mexico; Coll. Problems Drug
Dependence,1999, 61, 76.
200.
“Separation of Neuronal Nicotinic Receptor Antagonist Activity and Dopamine Uptake
Inhibition by Structural Modification of the Lobeline Molecule.” Marlon D. Jones, M.
Dathan Chesnut, Linda P. Dwoskin, and Peter A. Crooks, Proceedings of the 218th
American Chemical Society National Meeting, August, 1999, New Orleans, LA, Abstract
No. MEDI 106.
201.
"Azabicyclic Nicotine Analogs: Potent Agonists at Nicotinic Acetylcholine Receptors."
Merouane Bencherif, Balwinder S. Bhatti, William S. Caldwell, Jeffrey D. Schmitt, and
Peter A. Crooks, Society for Neuroscience Annual Meeting, October, 1999, Miami Beach,
FL: Soc. Neurosci. Abstr., 1999, 25,(part 2), p1982, Abstract 786.12.
202.
"Diaminoanthraquinones as Novel Ligands at the Polyamine Binding Site on the NMethyl-D-aspartate Receptor Complex." Aimee K. Bence, D. Trent Rogers, David R.
Worthen, Mai Fu, John M. Littleton, and Peter A. Crooks, Annual Meeting and Exposition
of the American Association of Pharmaceutical Scientists, November, 1999, New
Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-117, Abstract 2122.
203.
"Molecular Characterization of the Binding Site of the Blood-Brain Barrier Choline
Transporter Using Stereoisomer and Rigid Cyclic Structures." K. T. Fitzpatrick, J. W.
Beach, Quentin R. Smith, A. H. Shojaei, Peter A. Crooks, and David D. Allen, Annual
95
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-245,
Abstract 2581.
204.
"In Vitro Evaluation of the Ability of L-Arginine Analogs to Inhibit Human Pancreatic
Cancer Cell Growth, Aimee K. Bence, Val R. Adams, and Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-397,
Abstract 3113.
205.
"Tryptamine and Related Indole Derivatives as Novel NMDA Receptor Modulators."
David R. Worthen, D. Trent Rogers, Aimee K. Bence, Mai Fu, John M. Littleton, and
Peter A. Crooks, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 1999, New Orleans, LA, AAPSPharmSci
(Supplement), 1999, 1(4), p. S-400, Abstract 3126.
206.
"Structure Activity Studies of Amino Biphenyl Compounds as Modulators of N-methyl-DAspartate Receptor Function." Aimee K. Bence, D. Trent Rogers, David R. Worthen, Mai
Fu, John M. Littleton, and Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, November, 1999, New Orleans, LA,
AASPharmSci (Supplement), 1999, 1(4), p. S-402, Abstract 3136.
207.
"Evaluation of N-Alkylated Pyridinium Analogs as Antagonists at the Putative 32
Nicotinic Acetylcholine Receptor Subtype." Joshua T. Ayers, Aaron J. Haubner, Vladimir
P. Grinevich, Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, November,
1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-402, Abstract
3137.
208.
"Synthesis of Pyridino N-Alkylated Bridged Nicotine Analogues as Potent Nicotinic
Receptor Antagonists." Rui Xu, Aaron J. Haubner, Linda P. Dwoskin, and Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999,
1(4), p. S-404, Abstract 3142.
209.
"Synthesis of Novel Prodrugs of Combretastatin A-4 with Increased Aqueous Solubility."
Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks, Hong Guo, and Paul Ashton,
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999,
1(4), p. S-433, Abstract 3255.
210.
"Synthesis and Properties of Biolabile Prodrugs and Codrugs of Stavudine." Grazyna
Cynkowska, Tadeusz Cynkowski, Peter A. Crooks, Hong Guo, and Paul Ashton, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 1999, New Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-435,
Abstract 3262.
211.
"Nicotine Metabolite Accumulation in Rat Brain after Peripheral Nicotine Adminitration."
Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, Annual Meeting and
96
Exposition of the American Association of Pharmaceutical Scientists, November, 1999,
New Orleans, LA, AAPSPharmSci (Supplement), 1999, 1(4), p. S-528, Abstract 3605.
212.
“Synthesis and Stability Studies of Novel Biolabile Prodrugs of 5-Fluorouracil.” Tadeusz
Cynkowski, Grazyna Cynkowska, Peter A. Crooks, Hong Guo, Thomas Smith, and Paul
Ashton, Proceedings of the 219th American Chemical Society National Meeting, March,
2000, San Francisco, CA, Abstract No. MEDI 56.
213.
“Novel Codrugs of 5-Fluoro-2'-deoxyuridine (Floxuridine) with Antiinflammatory Agents.”
Grazyna Cynkowska, Tadeusz Cynkowski, Peter A. Crooks, Hong Guo, Thomas Smith,
and Paul Ashton, Proceedings of the 219th American Chemical Society National Meeting,
March, 2000, San Francisco, CA, Abstract No. MEDI 57.
214.
“Synthesis and Evaluation of N-Alkylated Pyridinium Derivatives as Antagonists at the
Nicotinic Acetylcholine Receptor.” Joshua T. Ayers, Aaron Haubner, Vladimir P.
Grinevich, Linda P. Dwoskin, and Peter A. Crooks, Proceedings of the 219th American
Chemical Society National Meeting, March, 2000, San Francisco, CA, Abstract No. MEDI
275.
215.
“Synthesis and Evaluation of Some Conformationally Restricted Pyridino N-Alkylated
Nicotine Analogs as Nicotinic Receptor Antagonists". Rui Xu, Aaron Haubner, Vladimir P.
Grinevich, Linda P. Dwoskin, and Peter A. Crooks, Proceedings of the 219th American
Chemical Society National Meeting, March, 2000, San Francisco, CA, Abstract No. MEDI
276.
216.
"Conformationally Restrained Analogues of NONI and NDNI are Selective Antagonists at
the Putative Alpha3beta2 Nicotinic Acetylcholine Receptor (nAChR) Subtype". Peter A.
Crooks, Rui Xu, Vladimir P. Grinevich, Aaron J. Haubner, and Linda P. Dwoskin.
Proceedings of the College on Problems of Drug Dependence, Sixty Second Annual
Scientific Meeting, June 17-22, 2000, San Juan, Puerto Rico; Coll. Problems Drug
Dependence Abstracts, 2000, 62, p34.
217.
"Rigid Nicotine Analogs Provide Selectivity for Alpha7 Subunit-Containing Neuronal
Nicotinic Acetylcholine Receptors". Vladimir P. Grinevich, Rui Xu, Peter A. Crooks, and
Linda P. Dwoskin. Proceedings of the College on Problems of Drug Dependence, Sixty
Second Annual Scientific Meeting, June 17-22, 2000, San Juan, Puerto Rico; Coll.
Problems Drug Dependence Abstracts, 2000, 62, p59.
218.
"Lobeline Noncompetitively Inhibits Methamphetamine Self-Administration in Rats".
Steven B. Harrod, Jennifer E. Klebaur, S.B. Phillips, Peter A. Crooks, Linda P. Dwoskin,
Michael T. Bardo. Proceedings of the College on Problems of Drug Dependence, Sixty
Second Annual Scientific Meeting, June 17-22, 2000, San Juan, Puerto Rico; Coll.
Problems Drug Dependence Abstracts, 2000, 62, p63.
219.
"Effects of Lobeline on Methamphetamine- and Nicotine-induced Hyperactivity and
Sensitization." Dennis K. Miller, Thomas A. Green, Steven B. Harrod, Michael T. Bardo,
Peter A. Crooks, Linda P. Dwoskin. Proceedings of the College on Problems of Drug
Dependence, Sixty Second Annual Scientific Meeting, June 17-22, 2000, San Juan,
Puerto Rico; Coll. Problems Drug Dependence Abstracts, 2000, 62, p111.
97
220.
"Nornicotine Decreases Dopamine Clearance in Rat Striatum In Vivo." Lisa S. Middleton,
Wayne A. Cass, Rui Xu, Peter A. Crooks, and Linda P. Dwoskin, The FASEB Journal,
2000, 14, 658.
221.
"Accumulation of Nicotine (NIC), Nornicotine (NorNIC) and Cotinine (COT) in Rat Brain
after Peripheral Nicotine Administration." Linda P. Dwoskin, Omar A. Ghosheh, and Peter
A. Crooks, The FASEB Journal, 2000, 14, 659.
222.
"Synthesis and Pharmacology of Bis-3-Arylpropylamines." Marlon D. Jones, M. Dathan
Chesnut, A. Gabriela Deaciuc, Linda P. Dwoskin, and Peter. A. Crooks, Proceedings of
the 220th American Chemical Society National Meeting, August, 2000, Washington, DC,
Abstract No. MEDI 109.
223.
"Pharmacology of Lobeline and Meso-transdiene.." Dennis K. Miller, Marlon D. Jones, A.
Gabriela Deaciuc, Peter A. Crooks, and Linda P. Dwoskin, Neuronal Nicotinic
Receptors, 10th Neuropharmacology Conference, 2000, P1.19, p91.
224.
"Mecamylamine (MEC) Differentiates Two Distinct Mechanisms Underlying Nicotine
(NIC) Sensitization to Once-weekly NIC Injection." Lincoln H. Wilkins, Peter A. Crooks,
Michael T. Bardo, and Linda P. Dwoskin, Neuronal Nicotinic Receptors, 10th
Neuropharmacology Conference, 2000, Abstract P5.6, p186.
225.
"Nornicotine, a Tobacco Alkaloid and Nicotine Metabolite, Contributes to Tobacco
Dependence". Linda P. Dwoskin, Omar A. Ghosheh, Thomas A. Green, Lisa S.
Middleton, LiHong Teng, Lincoln H. Wilkins, Michael T. Bardo, and Peter A. Crooks, 11th
World Conference on Tobacco and Health, PO240, 412, 2000.
226.
"Synthesis, Characterization and Evaluation of Boron-Containing Alkaloids as Selective
Ligands for Nicotinic Acetylcholine Receptors". Xu Rui, Vladimir P. Grinevich, Aaron J.
Haubner, Linda P. Dwoskin, and Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October 29 - November 2, 2000,
Indianapolis, IN. AAPSPharmSci (Supplement), 2000, 2(4), S-86, Abstract 2585.
227.
"Evaluation of N-Alkylated Bis-pyridinium, Bis-quinolinium, and Bis-nicotinium Analogs as
Antagonists at the Putative Alpha3Beta2 and Alpha4Beta2 Nicotinic Acetylcholine
Receptor Subtypes". Joshua T. Ayers, Aaron J. Haubner, Vladimir P. Grinevich, A.
Gabriela Deaciuc, Linda P. Dwoskin, and Peter A. Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October 29 November 2, 2000, Indianapolis, IN. AAPSPharmSci (Supplement), 2000, 2(4), S-100,
Abstract 3240.
228.
"L-Canavanine as a Radiosensitization Agent in Human Pancreatic Cancer Cells." Aimee
K. Bence, Val R. Adams, and Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October 29 - November 2, 2000,
Indianapolis, IN. AAPSPharmSci (Supplement), 2000, 2(4), S-86, Abstract 2583.
229.
“Lobeline, a Nicotinic Receptor Antagonist.” Lincoln H. Wilkins, Dennis K. Miller, Peter A.
Crooks, and Linda P. Dwoskin, Society for Neuroscience Annual Meeting, November,
2000, New Orleans, LA; Soc. Neurosci. Abstr., 2000, 26, 377.
98
230.
“Development of Conformationally Restricted, Subtype-selective Nicotinic Receptor
Antagonists.” Aaron J. Haubner, Rui Xu, Vladimir P. Grinevich, Peter A. Crooks, and
Linda P. Dwoskin, Society for Neuroscience Annual Meeting, November, 2000, New
Orleans, LA; Soc. Neurosci. Abstr., 2000, 26, 378.
231.
“-Lobeline Attenuates Methamphetamine Self-administration, But Does Not Serve as a
Reinforcer in Rats.” Steven B. Harrod, S. B. Phillips, Thomas A. Green, Peter A. Crooks,
Linda P. Dwoskin, and Michael T. Bardo, Society for Neuroscience Annual Meeting,
November, 2000, New Orleans, LA; Soc. Neurosci. Abstr., 2000, 26, 789.
232.
"Synthesis and Evaluation of N-Alkylated Pyridinium Compounds as Antagonists at
Nicotinic Acetylcholine Receptor Subtypes." Joshua T. Ayers, Aaron J. Haubner,
Sangeetha P. Sumithran, Vladimir P. Grinevich, A. Gabriela Deaciuc, Linda P. Dwoskin,
and Peter A. Crooks, Proceedings of the 221th American Chemical Society National
Meeting, March, 2001, San Diego, CA, Abstract No. MEDI 82.
233.
"Nicotinic Receptor Modulation of Dopaminergic Transporter Function In Striatum and
Medial Prefrontal Cortex In Rats." Lisa S. Middleton, Wayne A. Cass, Peter A. Crooks,
and Linda P. Dwoskin, The FASEB Journal, 2001,15, A558.
234.
“Nicotinic Acetylcholine Receptor Affinities of Boron-Containing Nicotine Analogs”. By
Peter Crooks, Rui Xu, Linda P. Dwoskin, Vladimir P. Grinevich,and Gabriela Deaciuc,
Proceedings of the College on Problems of Drug Dependence, Sixty Third Annual
Scientific Meeting, June 16-21, 2001, Scottsdale, Arizona; Coll. Problems Drug
Dependence Abstracts, 2001, 63.
235.
“Defunctionalized Structural Analogs of Alpha-Lobeline Inhibit [3H]Dopamine Uptake into
Rat Striatal Synaptosomes”. Steven B. Harrod, Peter A. Crooks, Marlon D. Jones, and
Linda P. Dwoskin, Proceedings of the College on Problems of Drug Dependence, Sixty
Third Annual Scientific Meeting, June 16-21, 2001, Scottsdale, Arizona; Coll. Problems
Drug Dependence Abstracts, 2001, 63.
236.
“N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit [3H]Dopamine Uptake into
Rat Striatal Synaptosomes”. By Jun Zhu, Joshua T. Ayers, Omar Ghosheh, Peter A.
Crooks, and Linda P. Dwoskin, Proceedings of the College on Problems of Drug
Dependence, Sixty Third Annual Scientific Meeting, June 16-21, 2001, Scottsdale,
Arizona; Coll. Problems Drug Dependence Abstracts, 2001, 63.
237.
"Enhanced Brain Delivery of a Neuroactive Nicotine Analogue by the Blood-Brain Barrier
Choline Transporter." David D. Allen, Quentin R. Smith, Karen E. Roder, Linda P.
Dwoskin, and Peter A. Crooks, Proceedings of the Annual Cerebral Vascular Biology
Meeting, Cambridge, England, June, 2001.
238.
"Nicotinic Receptor Modulation of Dopamine Transporter (DAT) Function In Striatum and
Medial Prefrontal Cortex In Rats". Lisa S. Middleton, Wayne A. Cass, Peter A. Crooks,
and Linda P. Dwoskin, Gordon Research Conference on Catecholamines, July, 2001.
239.
"Meso-Transdiene, a Defunctionilized Analog of Lobeline, Inhibits Dopamine and
Serotonin Uptake Into Rat Striatal and Hippocampal Synaptosomes." Steven B. Harrod,
Peter A. Crooks, Jun Zhu, and Linda P. Dwoskin, Society for Neuroscience Annual
99
Meeting, San Diego, CA, November, 2001; Soc. Neurosci. Abstr., 2001, 31, 418,
Abstract 814.1.
240.
"Potent Inhibition of 42* and 32* Neuronal Nicotinic Receptors By Lobeline
Analogs." Dennis K. Miller, Peter A. Crooks, Guangrong Zheng, Gabriela A. Deaciuc,
and Linda P. Dwoskin, Society for Neuroscience Annual Meeting, San Diego, CA,
November, 2001; Soc. Neurosci. Abstr., 2001, 31, 444, Abstract 667.8.
241.
"Lobeline Attenuates Methamphetamine and Cocaine Self-Administration and Locomotor
Sensitization In Rats." Thomas A. Green, Dennis K. Miller, M. K. Wong, Steven B.
Harrod, Peter A. Crooks, Michael T Bardo, and Linda P. Dwoskin, Society for
Neuroscience Annual Meeting, San Diego, CA, November, 2001; Soc. Neurosci. Abstr.,
2001, 27, 453, Abstract 878.1.
242.
“Effect of Introducing Unsaturation into the N-Alkyl Chain of N-Octylnicotinium Iodide
(NONI) and N-Decylnicotinium Iodide (NDNI) on Inhibition of Neuronal Nicotinic
Receptors.” Vladimir P. Grinevich, Peter A. Crooks, Sangeetha P. Sumithran, A. Gabriela
Deaciuc, Rui Xu, Robert A. Yokel, Linda P. Dwoskin, Society for Neuroscience
Annual Meeting, San Diego, CA, November, 2001; Soc. Neurosci. Abstr., 2001, 31, 249,
Abstract 485.7.
243.
“Synthesis and Evaluation of Some Novel Heterocycles as Antagonists at the Dopamine
Transporter.” Guangrong Zheng, Steven B. Harrod, Linda P. Dwoskin, and Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, 2001, Denver, CO. PharmSci (Supplement), Abstract M2384, p139.
244.
"Synthesis, Characterization and Evaluation of Novel Analogs of (-)-Lobeline as
Antagonists at Nicotinic Acetylcholine Receptor Subtypes." Marhaba Hojahmat, Dennis
K. Miller, Gabriela A. Deaciuc, Marlon D. Jones, Guangrong Zheng, Linda P. Dwoskin,
and Peter A. Crooks, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, 2001, Denver, CO. PharmSci (Supplement), Abstract M2225,
p137.
245.
"Site-Directed Brain Drug Delivery of a Neuroactive Nicotine Analog Using the BloodBrain Barrier Choline Carrier." David D. Allen, Quentin R. Smith, Karen E. Roder, Linda
P. Dwoskin, and Peter A. Crooks, Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, 2001, Denver, CO. PharmSci (Supplement),
Abstract T3321, p152.
246.
"Isolation, Identification and Synthesis of Several New Minor Tobacco Alkaloids and their
Affinities for Different Subtypes of Neuronal Nicotinic Receptors." Xiaochen Wei, Linda P.
Dwoskin, A. Gabriela Deaciuc, and Peter A. Crooks, Annual Meeting and Exposition of
the American Association of Pharmaceutical Scientists, 2001, Denver, CO. PharmSci
(Supplement), Abstract M2375, p139.
247.
"Synthesis and Evaluation of -Amino and -Guanidino Alkane Sulphonate Esters as
Potential Polyamine Binding Site modulators of the N-Methyl-D-Aspartate (NMDA)
Receptor Complex." Neelankantan Sundar, Robert C. Holley, John M. Littleton, and Peter
A. Crooks, Annual Meeting and Exposition of the American Association of
100
Pharmaceutical Scientists, 2001, Denver, CO. PharmSci (Supplement), Abstract M2369,
p139.
248.
"Indole derivatives as Novel Polyamine Site Ligands at the N-Methyl-D-aspartate
Receptor." Vijayakumar N. Sonar, Robert C. Holley, John M. Littleton, and Peter A.
Crooks Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, 2001, Denver, CO. PharmSci (Supplement), Abstract M2353, p139.
249.
"The Antiproliferative and Immunotoxic Effects of L-Canavanine and L-Canaline.” Aimee
K. Bence, David R. Worthen, Val R. Adams, and Peter A. Crooks. Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, 2001, Denver, CO.
AAPSPharmSci (Supplement), 3: (3) Abstract W4371, p225.
250.
"Synthesis and Evaluation of N-Alkylated Bis-Pyridinium, Bis-Quinolinium, and BisNicotinium Analogs as Antagonisit at Nicotinic Acetylcholine Receptor Subtypes." Joshua
T. Ayers, Aaron Haubner, Vladimir P. Grinevich, A. Gabriela Deaciuc, Linda P. Dwoskin,
and Peter A. Crooks, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, 2001, Denver, CO. PharmSci (Supplement), Abstract M2328,
p138.
251.
"Synthesis and Evaluation of N-Alkylated Pyridinium Analogs as Antagonists at Nicotinic
Acetylcholine Receptor Subtypes." Joshua T. Ayers, Aaron Haubner, Vladimir P.
Grinevich, Linda P. Dwoskin, and Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, 2001, Denver, CO. PharmSci
(Supplement), Abstract M2340, p139.
252.
"Synthesis and Evaluation of Pyridino N-Unsaturated, Branched and Cycloalkyl Nicotine
Analogs as Nicotinic Receptor Antagonists." Rui Xu, Linda P. Dwoskin, Vladimir P.
Grinevich, Sangeetha P. Sumithran, A. Gabriela Deaciuc, and Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, 2001,
Denver, CO. PharmSci (Supplement), Abstract M2332, p138.
253.
“Arginine Analogues and the Sensitization of Drug-Resistant Tumor Cells”, Peter A.
Crooks, Proceedings of the Sixth International Meeting on Guanidino Compounds in
Biology and Medicine, 2001, Cincinnati, OH, Abstract 10.
254.
“Novel Subtype-selective Nicotinic Receptor (nAChR) Antagonists, “ Linda P. Dwoskin,
Vladimir P. Grinevich, Rui Xu, JoshuaT. Ayers and Peter A. Crooks. XIVth World
Congress of Pharmacology, The Pharmacologist, 2002, 44(2), (Supp1), A45-46.
255.
“Lobeline: A Potential Treatment for Psychostimulant Abuse Using VMAT2 as a Novel
Target.” Linda P. Dwoskin, Dennis K. Miller, Guangrong Zheng, Vladimir P. Grinevich,
Seth D. Norrholm, Steven B. Harrod, Michael T. Bardo, and Peter A. Crooks. Dopamine
2002, Satellite Meeting of the XIVth World Congress of Pharmacology, 2002, Abstr.
P2.13, pp. 135.
256.
“Interaction of N-n-Alkylated Nicotine Analogs with32* Nicotinic Receptors and
Dopamine Transporters”. Jun Zhu, Rui Xu, Joshua T. Ayers, Peter A. Crooks and Linda
P. Dwoskin, Soc. Neurosci. Abstr., 2002, 32: Abstr. 745.16.
101
257.
“Interaction of Meso-transdiene with Nicotinic Receptors and Dopamine Transporters:
The Importance of Side Chain Unsaturation” Seth D. Norrholm, Dennis K. Miller,
Marhaba Hojahmat, Peter A. Crooks and Linda P. Dwoskin. Soc. Neurosci. Abstr.,
2002, 32: Abstr. 807.2
258.
“Interaction of Lobelia Inflata Alkaloids and Synthetic Analogs with the Vesicular
MonoamineTransporter-2.” Vladimir P. Grinevich, Peter A. Crooks, Guangrong Zheng,
Marhaba Hojahmat, and Linda P. Dwoskin. Soc. Neurosci. Abstr., 2002, 32: Abstr.
343.7.
259.
“Synthesis and Evaluation of Novel (-)-Lobeline analogs as Ligands at the
Tetrabenazine Site of the Vesicular Monoamine Transporter (VMAT2).Guangrong
Zheng, Vladimir P. Grinevich, Linda P. Dwoskin, and Peter A. Crooks, Annual
Exposition and Meeting of the American Association of Pharmaceutical Scientists,
Toronto, Canada, AAPSPharmSci, 2002, 4, (4) Abstract M1152.
260.
“Synthesis and Evaluation of (-)-Lobeline Analogs as Antagonists at Neuronal Nicotinic
Acetylcholine Receptors.” Marhaba Hojahmat, Seth D. Norrholm, Dennis K. Miller,
Linda P. Dwoskin, and Peter A. Crooks. Annual Exposition and Meeting of the
American Association of Pharmaceutical Scientists,Toronto, Canada, AAPSPharmSci,
2002, 4, (4) Abstract M1191.
261.
“Synthesis of Novel 2-Aryl Substituted Pyrrolidines and their Affinities for Neuronal
Nicotinic Acetylcholine Receptor Subtypes.” Xiaochen Wei, Peter A. Crooks and Linda
P. Dwoskin Annual Exposition and
Meeting of the
American Association of
Pharmaceutical Scientists,Toronto, Canada, AAPSPharmSci, 2002, 4, (4) Abstract
M1145.
262.
“Sulfur Isosteres of Tryptamine as Novel Polyamine Site Ligands at the N-Methyl-DAspartate Receptor.” Vijayakumar N. Sonar, John M. Littleton, Robert C. Holley, and
Peter A. Crooks. Annual Exposition and Meeting of the American Association of
Pharmaceutical Scientists,Toronto, Canada, AAPSPharmSci, 2002, 4, (4) Abstract
M1149.
263.
“Synthesis and Evaluation of Agmatine Analogs as Neuroprotective Agents at the NMethyl-D-Aspartate (NMDA) Receptor Complex.” Joshua R. Ring, John M. Littleton, and
Peter A. Crooks. Annual Exposition and Meeting of the American Association of
Pharmaceutical Scientists,Toronto, Canada, AAPSPharmSci, 2002, 4, (4) Abstract
M1151.
264.
“Synthesis and Evaluation of Substituted Hydantoins as Potential Polyamine Binding
Site Modulators at the N-Methyl-D-Aspartate Receptor Complex.” Sundar
Neelankantan, Robert C. Holley, John M. Littleton, and Peter A. Crooks. Annual
Exposition and Meeting of the American Association of Pharmaceutical Scientists,
Toronto, Canada, AAPSPharmSci, 2002, 4, (4) Abstract M1156.
265.
“Development of Novel Pharmacotherapies for Methamphetamine Abuse: cis-Lobelane,
an Analog of Lobeline”. Dennis K. Miller, Guangrong Zheng, Seth D. Norrholm, Vladimir
P. Grinevich, Peter A. Crooks, and Linda P. Dwoskin, Experimental Biology, 2003,
Abstract 140.7, p53.
102
266.
“Development of a Pharmacotherapy for Tobacco Use Cessation: bPiDDB, a Potent,
and Selective 362* Nicotinic Receptor Antagonist”. Sangitha P. Sumithran, Peter A.
Crooks, Gabriela A.Deaciuc, Joshua T. Ayers, and Linda P. Dwoskin, Experimental
Biology, 2003, Abstract 390.10, p151.
267.
“Development of novel Treatments for Nicotine Addiction: bis-Picolinium, a Very Potent
and Selective Antagonist at Nicotinic Receptor Subtypes Mediating Nicotine-evoked
Dopamine Release”. Linda P. Dwoskin, Sangitha P. Sumithran, Joshua T. Ayers and
Peter A. Crooks, Annual Meeting of the Society for Research on Nicotine and Tobacco,
New Orleans, LA, February, 2003. Soc. Res. Nicotine and Tobacco, 2003, 9:4, Abstract
POS3-13.
268.
“Development of Bio-active Probes Derived from Bacteriophage”. Clair L. Hicks, and
Peter A. Crooks. First Annual Kentucky Innovation and Enterprise Conference
Proceedings Lexington, KY, March, 2003.
269.
“Structural Modification of the Alkyl Chain of N-n-Alkylnicotinium Compounds: Affinity for
Alpha4beta2* Nicotinic Receptors”. Peter A. Crooks, Rui Xu, A. Gabriela Deaciuc,
Sangetha P. Sumithran, and Linda P. Dwoskin, Annual Meeting of the College on
Problems of Drug Dependence, Bal Harbour, FL, June, 2003. Drug and Alcohol
Dependence, 2003, 65, 10.
270.
“Development of Subtype-Selective Nicotinic Receptor Ligands as Receptor
Antagonists”, Peter A. Crooks, College on Problems of Drug Dependence Special
Symposium Series: Neuronal Nicotinic Receptors and Ligands: Targets for Medication.
Bal Harbor, Florida, June, 2003.
271. “A Duplex Prodrug of Naltrexone for Transdermal Delivery”. Denise C. Hammell, Mohamad
Hamad, Audra L. Stinchcomb, and Peter A. Crooks . Gordon Research Conference on
the Barrier Function of Mammalian Skin, Rhode Island, August, 2003.
272.
“Structure-Activity Relationships between Parthenolide and its Water-Soluble
Derivatives”, Miralis I. Gilbes, Xiaochen Wei, Craig Jordan, and Peter A. Crooks, 2003
Annual Biomedical Research Conference for Minority Students, 2003, Abstract 556, San
Diego, CA, October, 2003.
273.
“Interaction of Cis-Lobelane and its Analogs at the Vesicular Monoamine Transporter
(VMAT2)”, Seth D. Norrholm, Guangrong Zheng, A. Gabriela Deaciuc, Jun Zhu, Peter A.
Crooks, and Linda P. Dwoskin, Soc. Neurosci. Abstr. 2003, 33: Abstract 961.2We.
274.
“Synthesis, Characterization and Evaluation of Novel Lobelane Analogs at the Vesicular
Monoamine Transporter (VMAT2)”, Guangrong Zhang, Seth D. Norrholm, J. Gabriela
Deaciuc, Jun Zhu, Linda P. Dwoskin, and Peter A. Crooks, Annual Exposition and
Meeting of the American Association of Pharmaceutical Scientists, Salt Lake City, UT,
AAPSPharmSci, 2003, 5, (4) Abstract M1146.
275.
“A Stability Study of Dantrolene Sodium”, Abeer Al-Ghananeem, Sundar Neelakantan,
and Peter A. Crooks, Annual Exposition and Meeting of the American Association of
103
Pharmaceutical Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5, (4) Abstract
T2002.
276.
“A Novel “Gemini” Prodrug of Naltrexone for Transdermal Delivery”, Mohamad O.
Hamad, Denise C. Hammell, Audra L. Stinchcomb, and Peter A. Crooks, Annual
Exposition and Meeting of the American Association of Pharmaceutical Scientists, Salt
Lake City, UT, AAPSPharmSci, 2003, 5, (4) Abstract Mxxx.
277.
“Antileukemic Activity of Parthenolide Analogs”, Xiaochen Wei, Monica Guzman, Craig
Jordan, and Peter A. Crooks, Annual Exposition and Meeting of the American
Association of Pharmaceutical Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5,
(4) Abstract M1144.
278.
“Carbonate Ester Prodrugs of Naltrexone for Transdermal Delivery”, Mohamad O.
Hamad, O. Pillai, Audra L. Stinchcomb, and Peter A. Crooks, Annual Exposition and
Meeting of the American Association of Pharmaceutical Scientists, Salt Lake City, UT,
AAPSPharmSci, 2003, 5, (4) Abstract M1102.
279.
“Identification and Mechanism of Action of Novel 2-Indol-3-ylmethylene-quinuclidin-3-ol
Analogs as Chemopreventative Agents”, Vijayakumar N. Sonar, S. R. Konjeti, Michael L.
Freeman, and Peter A. Crooks, Annual Exposition and Meeting of the American
Association of Pharmaceutical Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5,
(4) Abstract M1142.
280.
“Novel Aromatic Agmatine Analogs as Competitive Antagonists at the N-Methyl-Daspartate (NMDA) NR2B Coreceptor”, Joshua R. Ring, John M. Littleton, and Peter A.
Crooks, Annual Exposition and Meeting of the American Association of Pharmaceutical
Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5, (4) Abstract M1133.
281.
“Synthesis and Evaluation of Substituted Amino Guanidines as Potential Polyamine
Binding Site Modulators of the N-Methyl-D-aspartate (NMDA) Receptor Complex”,
Sundar Neelakantan, Robert C. Holley, John M. Littleton, and Peter A. Crooks, Annual
Exposition and Meeting of the American Association of Pharmaceutical Scientists, Salt
Lake City, UT, AAPSPharmSci, 2003, 5, (4) Abstract M1107.
282.
“Aromatic Sulfonic Acid Esters of (-)-2R,6S,8S-Lobeline Act as Antagonists at 42* and
362* Nicotinic Receptors”, Marhaba Hojahmat, Seth D. Norholm, Monica King, Linda
P. Dwoskin, and Peter A. Crooks, Annual Exposition and Meeting of the American
Association of Pharmaceutical Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5,
(4) Abstract M1137.
283.
“Naltrexone and Naltrexone-3-Valerate Diffusion and Bioconversion in a Human
Epidermis Equivalent”, Audra L. Stinchcomb, Denise C. Hamell, E. Stolarczyk, Mohamad
O. Hamad, and Peter A. Crooks, Annual Exposition and Meeting of the American
Association of Pharmaceutical Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5,
(4) Abstract T2207.
284.
“Rapid Synthesis and High-Throughput Pharmacological Evaluation of Novel Nicotinic
Receptor Ligands”, Aaron J. Haubner, May Fu, John M. Littleton, and Peter A. Crooks,
104
Annual Exposition and Meeting of the American Association of Pharmaceutical
Scientists, Salt Lake City, UT, AAPSPharmSci, 2003, 5, (4) Abstract M1130.
285.
“Interaction of Cis-lobelane and its Analogs at the Vesicular Monoamine Transporter
(VMAT2)”, Norrholm, Seth D., Zhang, Guangrong, Deaciuc, J., Zhu, Jun, Crooks, Peter
A. and Dwoskin, Linda P. (2003), Soc. Neurosci. Abstr., 2003, 33: Abstr. 961.2We.
286.
“Testing of Chemistry for Two Rapid Assay Probes”, Claire L. Hicks and Peter A. Crooks,
Second Annual Kentucky Innovation and Enterprise Conference, Louisville, KY, March
3rd, 2004.
287.
“Development of Bio-probe Chemistry”, Claire L. Hicks and Peter A. Crooks, Second
Annual Kentucky Innovation and Enterprise Conference, Louisville, KY, March 3rd, 2004.
288.
“Synthesis and Comparative Pharmacological Activities of Lobelane Isomers at VMAT2”,
Guangrong Zheng, Seth D. Norrholm, Linda P. Dwoskin, and Peter A. Crooks, Annual
Meeting of the College on Problems of Drug Dependence, 66, Abstract 36, p.34, San
Juan, Puerto Rico, June, 2004.
289.
“Lobelane, a Potent Lobeline Analog, Inhibits Methamphetamine-Evoked Dopamine
Release from Rat Striatal Slices”, S. Krishnamurthy, Seth D. Norrholm, Guangrong
Zheng, Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting of the College on
Problems of Drug Dependence, 66, Abstract 37, p.34, San Juan, Puerto Rico, June,
2004.
290.
“Effects of Lobelane on Methamphetamine Self-Administration and Sucrose-Maintained
Responding”, Nichole M. Neugebauer, Steven B. Harrod, Dustin J. Stairs, Guangrong
Zheng, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Annual Meeting of the
College on Problems of Drug Dependence, 66, Abstract 38, p.34, San Juan, Puerto Rico,
June, 2004.
291.
“Nicotine-Boron: A Novel Potent Antagonist at Alpha6beta2* Nicotinic receptors in rat
Striatum”, Sangeetha P. Sumithram, Peter A. Crooks, J. Zhu, Guangrong Zheng, Roger
L. Papke, and Linda P. Dwoskin, Annual Meeting of the College on Problems of Drug
Dependence, 66, Abstract 35, p.53, San Juan, Puerto Rico, June, 2004.
292.
“A New Method for GC/MS Quantification of Nornicotine in Rat Brain and Blood after
Acute Subcutaneous pretreatment with Nornicotine Enantiomers”, Xioachen Wei, Dustin
J. Stairs, Nichole M. Neugebauer, Michael T. Bardo, Linda P. Dwoskin, and Peter A.
Crooks, Annual Meeting of the College on Problems of Drug Dependence, 66, Abstract
38, p.53, San Juan, Puerto Rico, June, 2004.
293.
“Enantiomeric Effects of Nornicotine on Nicotine self-Administration and SucroseMaintained Responding in Rats”, Dustin J. Stairs, Nichole M. Neugebauer, Xiaochen
Wei, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Annual Meeting of the
College on Problems of Drug Dependence, 66, Abstract 39, p.53, San Juan, Puerto
Rico, June, 2004.
294.
“Defunctionalized Lobeline Analogs Inhibit Methamphetamine-Evoked Dopamine
Release from Rat Striatal Slices”, Sairam Krishnamurthy, Peter A. Crooks, Guangrong
105
Zheng, and Linda P. Dwoskin, Frontiers in Addiction Biology-Genomics and Beyond,
Vanderbilt University Summer Conference, Nashville, TN, June, 2004.
295.
“The Unsaturated N-n-Alkylnicotinium Analog, NONB3t, is a Potent and Selective
Antagonist at Nicotinic Receptors (62*) Mediating Nicotine- Evoked [3H]Dopamine
Release from Rat Striatal Slices”, Sangeetha P. Sumithran, Jun Zhu, A.Gabriela Deaciuc,
Rui Xu, Peter A. Crooks and L.P. Dwoskin, Frontiers in Addiction Biology-Genomics and
Beyond, Vanderbilt University Summer Conference, Nashville, TN, June, 2004.
296.
“The PLP-dependent Arginine Decarboxylase from Yersinia pestis: a Link Between
Polyamine Biosynthesis and Biofilm Formation”. Chandra N. Patel, Korie G. Sell, Brian
Wortham, Paul Balbo, Robert S. Adcock, Peter, A. Crooks, Isaac Wong, Jacqueline
Fetherston, Robert D. Perry and Marcos A. Oliveira, Gordon Research Conference:
Enzymes Co-enzymes and Metabolic Pathways, Kimball Union Academy, Meriden, NH,
July, 2004.
297.
“Arginine Decarboxylase a Target for the Design of Novel Biodefense Agents”, Chandra
N. Patel, Korie G. Sell, Robert S. Adcock, Paul Balbo, Peter, A. Crooks, Jacqueline D.
Fetherston, Robert D. Perry, and Marcos A. Oliveira, American Crystallographic
Association Meeting, August, 2004.
298.
“Bis-Quinolinium and bis-Isoquinolinium Quaternary Ammonium Analogs Potently Inhibit
Nicotinic Receptors Mediating Nicotine-Evoked Striatal Dopamine Release”, Sangeetha
P. Sumithran, Peter A. Crooks, A. Gabriela Deaciuc, Joshua T. Ayers and Linda P.
Dwoskin, Soc. Neurosci. Abstr., 2004, 34, Abstract 918.12-W. San Diego, CA, October,
2004.
299.
“The Effects of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide (bPiDDB), a Novel
Nicotinic Receptor Antagonist, on Nicotine-induced Behaviors”, Nichole M. Neugebauer,
Joshua T. Ayers, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, 10th Annual
Duke Nicotine Research Conference, Durham, NC, October, 2004.
300.
“Preparation and Purification of Amino Derivatives of Dehydrocostus Lactone and their
Antileukemic Activities Against Primary Human Acute Myelogenous Leukemia Cells in
Culture”, Marlene Cotto, Xiaochen Wei, Monica Guzman , Craig Jordan, and Peter A.
Crooks, The 2004 Annual Biomedical Research Conference for Minority Students,
November, 2004, Dallas, TX, Abstract No. 190. A134.
301.
“A Gas Chromatography and Mass Selective method for the Determination of Fentanyl
in Plasma at Subnanogram Levels”, Ahmad Malkawi, Abeer Al Ghananeem, Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2004, Baltimore, MD., Abstract T2039, p68.
302.
“Synthesis and Development of Rapid Assay Probes for Derived from Bacteriophage”,
Sundar Neelakantan, I. Surjawan, H. Karacelik, Clair L. Hicks, Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2004, Baltimore, MD., Abstract T2058, p68.
303.
“Preparation, Chiral Separation, Characterization and Analgesic Properties of
Norketamine”, Marhaba Hojahmat, Joseph Holtman, Elzbieta Wala, Robert Alonso, and
106
Peter A. Crooks, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract W4012, p93.
304.
“3-O-Oxaacyl Naltrexone Prodrugs for Transdermal Delivery”, Jianghong Chen, H.K.
Vaddi, X. Yu, Audra L. Stinchcomb, Peter A. Crooks, Annual Meeting and Exposition of
the American Association of Pharmaceutical Scientists, November, 2004, Baltimore,
MD., Abstract W4064, p95.
305.
“Synthesis and Evaluation of Nicotine Analogs as Ligands for α4β2* Neuronal Nicotinic
Acetylcholine Receptors”, Jianghong Chen, Aaron J. Haubner, Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2004, Baltimore, MD., Abstract W4065, p95.
306.
“Carbamate Prodrugs of Naltrexone for Transdermal Delivery”, Mohamad Ahmad,
Jianghong Chen, H. Vaddi, Audra L. Stinchcomb, Peter A. Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2004,
Baltimore, MD., Abstract W4067, p95.
307.
(±)-Norketamine for Treatment of Neuropathic Pain”, Joseph Holtman, Jr., Peter A.
Crooks, Robert Alonso, Marhaba Hojahmat, Elzbieta Wala, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2004,
Baltimore, MD., Abstract W4083, p95.
308.
“Synthesis and Evaluation of Novel Aromatic Agmatine Analogs at Polyamine Binding
Sites within the N-Methyl-D-Aspartate (NMDA) Receptor Complex”, Joshua Ring, John
M. Littleton, Peter A. Crooks, Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract
W4084, p95.
309.
“Synthesis and Anticancer Activity of 2-(1-Substituted-1H-indol-3-ylmethylene)-1azabicyclo[2.2.2]octan-3-ol Analogs”, Veejayakumar Sonar, Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2004, Baltimore, MD., Abstract W4094, p96.
310.
“Synthesis and Pharmacological Evaluation of Second Generation Guanidino-Containing
Nicotine Analogs: Improvements in Affinity at the Neuronal Nicotinic Receptor”, Aaron
Haubner, May Fu, John M. Littleton, Peter A. Crooks, Annual Meeting and Exposition of
the American Association of Pharmaceutical Scientists, November, 2004, Baltimore, MD.,
Abstract W4097, p96.
311.
“Computational Neural Network (NN) Prediction of the Antagonist Activity of Mono- and
Bis-Quaternary Ammonium Salts at the α6β2* (Dopamine Releasing) nAChR Subtype”,
Fang Zheng, Joshua T. Ayers, Jeffrey Schmitt, Chang-Guo Zhan, Linda P. Dwoskin, and
Peter A. Crooks, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract W4116, p97.
312.
“Synthesis and Pharmacological Studies of meso-Transdiene (MTD) and Lobelane
Stereoisomers to Inhibit Methamphetamine-evoked Dopamine Release from Rat Striatal
Slices”, Guangrong Zheng, Linda P. Dwoskin, S. Krishnamurthy, Peter A. Crooks, Annual
107
Meeting and Exposition of the American Association of Pharmaceutical
November, 2004, Baltimore, MD., Abstract W4117, p97.
Scientists,
313.
“S-(-)-Nornicotine – An Alternative to Nicotine for Treatment of Smoking Cessation
Through Transdermal Delivery”, Buchi Nalluri, Xiaochen Wei, Marhaba Hojahmat, Peter
A. Crooks, Audra Stinchcomb, Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract
W4201, p100.
314.
“Transdermal Permeation of Bupropion and Hydroxybupropion Across Human Skin In
Vitro”, Paul Kiptoo, Buchi Nalluri, Mohamad Hamad, Peter A. Crooks, Audra
Stinchcomb, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract W4202, p100.
315.
“In Vitro Human Skin Permation of Branched Chain 3-O-alkyl Ester Prodrugs of
Naltrexone”, H. Vaddi, Mohamad Hamad, Jianghong Chen, Peter A. Crooks, Audra
Stinchcomb, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract W4203, p100.
316.
“Transdermal Delivery of Naltrexone and its Active Metabolite 6-β-Naltrexol in Human
Skin In Vivo and in Guinea Pigs In Vivo”, Buchi Nalluri, K. Paudel, D. Hammall, S.
Valiveti, Paul Kiptoo, Mohamad hamd, Peter A. Crooks, Audra Stinchcomb, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2004, Baltimore, MD., Abstract W4204, p100.
317.
“Transdermal Delivery of a 3-O-Hexyl Ester Prodrug of Naltrexone in Hairless Guinea
Pigs”, S. Valiveti, D. Hammell, K. Paudel, Mohamad Hamad, Peter A. Crooks, Audra
Stinchcomb, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2004, Baltimore, MD., Abstract W4205, p100.
318.
“Development and In Vivo Release Studies of Pressure Sensitive Adhesive Based
Transdermal Drug Delivery Systems for Naltrexone and its Acetyl Prodrug”, Buchi
Nalluri, C. Milligan, Jianghong Chen, Peter A. Crooks, Audra Stinchcomb, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2004, Baltimore, MD., Abstract W4201, p100.
319.
“Efficient Synthesis of Fluorescent Rapid Assay Probes”, Sundar Neelakantan, H.
Karacelik, I. Surjawan, Peter A. Crooks, and Clair L. Hicks, Third Annual Kentucky
Innovation and Enterprise Conference Proceedings, March, 2005, Louisville, KY.
320.
“Fluorescent Rapid Assay Probes Derived from Phage Peptides”, H. Karacelik, I.
Surjawan, Sundar Neelakantan, Peter A. Crooks, and Clair L. Hicks, Third Annual
Kentucky Innovation and Enterprise Conference Proceedings, March, 2005, Louisville,
KY.
321.
“Pharmacology of the Bis-Picolinium Analog, bPiDDB: a Lead Compound in the
Development of Novel Subtype-Selective Nicotinic Receptor Antagonists as Treatments
for Smoking Cessation”, Linda P. Dwoskin, Sangeetha P. Sumithran, Nichole M.
Neugebauer, Guangrong Zheng, Gabi Deaciuc, Peter A. Crooks, and Michael T. Bardo,
11th Annual Meeting and 7th Annual European Conference of the Society for Research
108
on Nicotine and Tobacco, March 20th-23rd, 2005, Prague, Czechoslovakia.
322.
“Water Soluble Analogues of Parthenolide Retain Anti-Cancer Activity and are More
Orally Bioavailable”. Rajasubramaniam Shanmugam, Zhu Wei, Vetrichelvan
Jayaprakasan, Poornima Bhat-Nakshatri, Peter A. Crooks, Harikrishna Nakshathri, and
Christopher J. Sweeney. Annual National Meeting of the American Association for
Cancer Research, Anaheim, CA, April, 2005.
323.
“Parthenolide and its Water-soluble Analogs as Potent Antitumor Agents”, Sundar
Neelakantan, Xiaochen Wei, Rajasubramaniam Shanmugam, Zhu Wei, Vetrichelvan
Jayaprakasan, Poornima Bhat-Nakshatri,Harikrishna Nakshathri, Christopher J.
Sweeney, and Peter A. Crooks, Fourth Annual Lung Cancer Symposium, Evolving
Strategies in Lung Cancer Diagnosis and Treatment, University of Kentucky Markey
Cancer Center, Lexington, KY, April, 2005.
324.
“Parthenolides as Potential Treatments for Lung Cancer”, Sundar Neelakantan,
Xiaochen Wei, Rajasubramaniam Shanmugam, Zhu Wei, Vetrichelvan Jayaprakasan,
Poornima Bhat-Nakshatri,Harikrishna Nakshathri, Christopher J. Sweeney, and Peter A.
Crooks, Third Annual Meeting of the Kentucky Lung Cancer Research Program, May,
2005, Louisville, KY
325.
“Fluorescent Rapid Assay Probes Derived From Phage Peptides”, H. Karacelik, I.
Surjawan, Sundar Neelakantan, Peter A. Crooks, and Clair L. Hicks, Annual Meeting of
the Institute of Food Technologists, June, 2005, New Orleans, LA.
326.
“Polyamines are Essential for the Formation of an Infectious Plague Biofilm”. Chandra
N. Patel, Korie G. Sell, Brian Wortham, Robert S. Adcock, Peter, A. Crooks, Isaac
Wong, Robert D. Perry and Marcos A. Oliveira, Gordon Research Conference:
Polyamines, Connecticut College, June, 2005, New London, CT.
327.
“Long Chain N-n-Alkylnicotinium Analogs Inhibit Nicotinic Receptors Probed by
[3H]Nicotinic binding, but not [3H]Methyllycaconitine Binding to Rat Brain Membranes”.
Peter A. Crooks, Guangrong, A. Gabriela Deaciuc, Fang Zheng, and Linda P. Dwoskin,
Sixty Seventh Annual Meeting of the College on Problems of Drug Dependence, 67,
Abstract 915, p77, Orlando, FL, June, 2005.
328.
“Effect of a Novel Nicotinic Receptor Antagonist, N, N”-Dodecyl-1, 12-diyl-bis-3picolinium Dibromide, on Nicotine Self-administration and locomotor Activity in Rats”.
Nicole M. Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael
T. Bardo Sixty Seventh Annual Meeting of the College on Problems of Drug
Dependence, 67, Abstract 100, p53, Orlando, FL, June, 2005.
329.
“Novel reporter Molecule for the Development of Rapid Assay Probes”. I. Surjawan,
H. Karacelik, Sundar Neelakantan, Peter A. Crooks, and Clair L. Hicks, Annual Meeting
of the American Dairy Science Association, July, 2005, Cinicinnatti, OH; J. Dairy Sci.,
86, Suppl. 1.
330.
“Radiosensitization by the Combination of 41oC Hyperthermia and Indomethacin”. Mai
Xu, M. Wu, Peter A. Crooks, Michael Freeman and Joseph Roti Roti, Radiation
109
Research Society, Fifty Second Annual Meeting, Experimental Therapeutics Poster
Discussion on Tumor Targetting, Abstract PD015, October, 2005, Denver, CO.
331.
“Development of Enhancers of Thermal Radiosensitization”. Michael Freeman, Sekhar
Konjeti, Buck Rogers, Peter A. Crooks, Mai Xu, Eduardo Moros, and Joseph Roti Roti,
Radiation Research Society, Fifty Second Annual Meeting, Experimental Therapeutics
Poster Discussion on Tumor Targetting, Abstract PP110, October, 2005, Denver, CO.
332.
“Radiosensitization by the Combination of 41oC Hyperthermia and Indomethacin”. Mai
Xu, M. Wu, Peter A. Crooks, Michael Freeman and Joseph Roti Roti, Radiation
Research Society, Fifty Second Annual Meeting, Experimental Therapeutics Poster
Discussion on Tumor Targetting, Abstract PP167, October, 2005, Denver, CO.
333.
“Multiple Species of Nicotine and Deschloroepibatidine Interacting with the α4β2
Nicotinic Acetylcholine Receptor: From Microscopic Binding to Phenomenological
Binding Affinity”. Xiaoqin Huang, Fang Zheng, Peter A. Crooks, Linda Dwoskin, ChangGuo Zhan, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract M1122 (2005).
334.
“Synthesis and Development of Antibiotic Delivery Probes Derived from Bacteriophage”.
Sundar Neelakantan, Iwan Surjawan, Huseyin Karacelik, Clair L Hicks, Peter A Crooks,
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
M1127 (2005).
335.
“Identification of 2, 2'-Dipyridyl in Human Plasma”. Shama Nasim, Xiaochen Wei, Jose
de Leon, Peter A. Crooks, Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract W5053 (2005).
336.
“Enantiomeric Ratio of (R)- and (S)-Nornicotines in Different Nicotiana Species”.
Xiaochen Wei, David M. Crooks, Ruth Babbitt, David Zaitlin, Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract T2113
(2005).
337.
“Pharmacological Characterization and Molecular Modeling Predictions of Novel
Guanidine Containing Nicotine Analogs”. Aaron Haubner, John Littleton, Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
T2115 (2005).
338.
“Parthenolide and its Water Soluble Analogs as Potent Anti-tumor Agents”. Sundar
Neelakantan, XiaoChen Wei, Rajasubramaniam Shanmugam, Zhu Wei, Vetrichelvan
Jayaprakasan, Poornima Bhat Nakshatri, Harikrishna Nakshathri, Christopher J.
Sweeney, Peter A. Crooks, Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract T2120 (2005).
110
339.
“QSAR Study on the Affinity of Lobeline and Lobeline Analogs for the Vesicular
Monoamine Transporter-2 (VMAT-2) Within the Presynaptic Terminal”. Fang Zheng,
Guangrong Zheng, Agripina G. Deaciuc, Linda P. Dwoskin, Peter A. Crooks, Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract T2124
(2005).
340.
“Synthetic Strategies for the Preparation of “Gemini” Codrugs of Naltrexone, and Hetero
Codrugs of β-Naltrexol with Hydroxybupropion for Transdermal Delivery”. Mohamed
Hamad, Paul Kiptoo, Audra Stinchcomb, Peter Crooks, Annual Meeting and Exposition
of the American Association of Pharmaceutical Scientists, November, 2005, Nashville,
TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4067 (2005).
341.
“S(-)-Norketamine for Treatment of Neuropathic Pain”. Joseph R. Holtman, Jr, Peter A.
Crooks, Robert Alonso, Marhaba Hojahmat, Elzbieta Wala, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2005,
Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4069 (2005).
342.
“Synthesis and development of Indole Analogues Related to Indomethacin as Adjuvant
Radiosensitization Agents”. Venkatraj Muthusamy, Vijayakumar Sonar, Konjeti R.
Sekhar, Michael L. Freeman, Joseph L. Roti Roti, Peter A. Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2005,
Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4071 (2005).
343.
“Synthesis and Antitubercular Activity of a Series of Hydrazone Derivatives of Indole-3,benzo[b]thiophen-3- and Thiophene-3-carboxaldehyde”. Vijayakumar Sonar, Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
W4075 (2005).
344.
“Synthesis of bis-Pyridinium Analogs and Structurally Related Cyclophanes with High
Affinity for the Blood Brain Barrier Choline Transporter”. Zhenfa Zhang, Paul Lockman,
Werner J. Geldenhuys, David Allen, Linda Dwoskin, Peter A. Crooks, Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, November,
2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4079 (2005).
345.
“3D-QSAR Studies on the Affinity of Semi-rigid Bis-Quaternary Nicotinium Compounds
for the Blood Brain Barrier Choline Transporter”. Fancy Thomas, Werner Geldenhuys,
Paul Lockman, Tiffany Nguyen, Cornelis Van der Schyf, Zhenfa Zhang, Peter Crooks,
Linda Dwoskin, David Allen, Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract R62021 (2005).
346.
“Synthesis and Pharmacological Studies of Mono-Hydroxy Lobeline Analogs to Inhibit
[3H]5-Hydroxytryptamine and [3H]Dopamine Uptake into Rat Hippocampal and Striatal
Synaptosomes”. Guangrong Zheng, David Horton, Linda Dwoskin, Peter A. Crooks,
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
T2125 (2005).
111
347.
“Transdermal Permeation of 6-Beta-Naltrexol Hydrochloride Versus Base After
Microneedle Treatment of Hairless Guinea Pigs”. Stan Banks, Mohamed Hamad,
Raghotham Pinninti, Harvinder Gill, Mark Prausnitz, Peter A. Crooks, Audra Stinchcomb,
Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
R6055 (2005).
348.
“Transdermal Delivery of Bupropion and Hydroxybupropion In Hairless Guinea Pigs In
Vivo”. Paul Kiptoo, Kalpana Paudel, Dana Hammell, Mohamed Hamad, Peter A. Crooks,
Audra Stinchcomb, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract R6091 (2005).
349.
“6-β[beta]-Naltrexol Human Skin Permeation Enhancement In Vitro Using a
Hydroxybupropion Codrug”. Paul Kiptoo, Mohamed Hamad, Peter A. Crooks, Audra
Stinchcomb, Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7,
No. S2, Abstract R6093 (2005).
350.
“Synthesis of Hydroxybupropion Prodrugs for Transdermal Delivery”. Jianhong Chen1,
Paul Kiptoo, Audra Stinchcomb, Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, November, 2005, Nashville, TN, The
AAPS Journal, Vol. 7, No. S2, Abstract M1108 (2005).
351.
“Sublingual Drug Delivery of Nicotine for Smoking Cessation”. Abeer Al-Ghananeem,
Ahmad Malkawi, Xiaochen Wei, Peter A. Crooks, Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, November, 2005, Nashville, TN, The
AAPS Journal, Vol. 7, No. S2, Abstract T2130 (2005).
352.
“A novel Synthesis of R-(+)-Nornicotine, a Potential Smoking Cessation Agent, via NDemethylation of R-(+)-Nicotine”. Marhaba Hojahmat, Xiaocheng Wei, Linda Dwoskin,
Michael Bardo, Peter A. Crooks, Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, November, 2005, Nashville, TN, The AAPS
Journal, Vol. 7, No. S2, Abstract W4068 (2005).
353.
“N-Alkylpyridinium- and bis-N, N’-Alkylpyridinium Analogs as Nicotinic Receptor
Antagonists: Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptor Subtypes
that Mediate Nicotine-evoked Dopamine Release”. Zhenfa Zhang, Sangeetha P
Sumithran, Gabi Deaciuc, Linda Dwoskin, Peter A. Crooks, Michael Bardo, Peter A.
Crooks, Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, November, 2005, Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract
W4080 (2005).
354.
“Synthesis of bis-Pyridinium Analogs and Structurally Related Cyclophanes with High
Affinity for the Blood Brain Barrier Choline Transporter”. Zhenfa Zhang, Paul Lockman,
Werner J. Geldenhuys, David Allen, Linda Dwoskin, Peter Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2005,
Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4079 (2005).
112
355.
“Sublingual Drug Delivery of Oxycodone for Acute Pain Management”. Abeer AlGhananeem, Ahmad Malkawi, George Digenis, Peter A. Crooks, Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, November, 2005,
Nashville, TN, The AAPS Journal, Vol. 7, No. S2, Abstract W4120 (2005).
356.
“Parthenolide Selectively Sensitizes Prostate Cancer Cells but not Normal Prostate
Epithelial Cells to Radiation Treatment through Inhibition of NF-KB Activation”. Yulan
Sun, Graham Warren, Daret St. Clair, Peter A. Crooks, and William St. Clair, Annual
Meeting of the Free Radical Research Society, 2005, 39, S169.
357.
“Effects of Novel N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide on Acute NicotineInduced Changes in Brain Dopamine Function”, S. Rahman, Nicole M. Neugebauer,
Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Soc. Neurosci.
Abstr., 2005, 35, Abstract 158.15, Washington, DC, November, 2005.
358.
“Sulfate Esters of Lobeline: Interaction at Neurotransmitter Transporters and Nicotinic
Receptors”, David B. Horton, Marhaba Hojahmat, Seth D. Norrholm, G.Kaprit Dhawan,
Peter A. Crooks, and Linda P. Dwoskin, Soc. Neurosci. Abstr., 2005, 35, Abstract
227.11, Washington, DC, November, 2005.
359.
“Effect of Lobeline Analogs to Inhibit Nicotine- and Methamphetamine-Evoked Dopamine
Overflow from Rat Striatal Slices: Novel Therapeutic Agents with Potential for the
Treatment of Psychostimulant Abuse”. Linda P. Dwoskin, G. Kaprit Dhawan, Guangrong
Zheng, A. Gabriela Deaciuc, S. Krishnamurthy, and Peter A. Crooks, Soc. Neurosci.
Abstr., 2005, 35, Abstract 681.17, Washington, DC, November, 2005.
360.
“The Novel Nicotinic Receptor Antagonists N,N’-Dodecane-1,12-diyl-bis-3-picolinium
Dibromide Inhibits Nicotine-Evoked [3H]Norepinephrine Overflow from Superfused Rat
Hippocampal Slices”. Sangeetha P. Sumithran, G. Kaprit Dhawan, Guangrong Zheng,
Peter A. Crooks, and Linda P. Dwoskin, Soc. Neurosci. Abstr., 2005, 35, Abstract
961.17, Washington, DC, November, 2005.
361.
“The Effect of S(-)-Norketamine on Oxycodone Analgesia in Rats”. By Elzbieta P. Wala,
Peter A. Crooks, J. K. Johnson, and Joseph R. Holtman, Jr., Soc. Neurosci. Abstr., 2005,
35, Abstract 49.10, Washington, DC, November, 2005.
362.
“Synergistic Radiosensitization of Lung Cancer Cells Using Parthenolide and Low Dose
Combinations of Proteasome or Cycloxygenase Inhibitors”. Graham W. Warren, K. R.
Grimes, Peter A. Crooks, and William H. St. Clair, Int. J. Radiat. Oncol. Biol. Phys. 2005,
63: S391, Abstract 2275.
363.
“A Novel Drug for Chronic Pain”. Joseph R. Holtman, Jr., Peter A. Crooks, Elzbieta P.
Wala, Postgraduate Assembley in Anesthesiology, New York State Society of
Anesthesiologists, December, 2005, New York, NY.
364.
“Development of Novel Nicotinic receptor Antagonists as Treatments for Nicotine
Addiction”. Linda P. Dwoskin. Peter A. Crooks, Michael T. Bardo, Roger L. Papke,
Davis D. Allen, and Paul R. Lockman, National Cooperative Drug Discovery Groups for
Nicotine Addiction: NIDA Symposium Meeting, Orlando, FL, February, 2006.
365.
“Differing Activity Profiles of Nicotine and its CNS metabolite and Tobacco alkaloid,
113
Nornicotine”. Roger L. Papke, Linda P. Dwoskin, and Peter A. Crooks, Society for
Research on Nicotine and Tobacco, Twelth Annual Meeting, Orlando, FL, February,
2006.
366.
“The Effect of S-Norketamine on the Development of Tolerance to Opioids in Rats”. By
Joseph R. Holtman, Wendell G. Griffin, Peter A. Crooks, and Elzbieta P. Wala,
International Anesthesia Research Association Annual Meeting, Abstract S-224, San
Fransisco, CA, March, 2006.
367.
“Water-soluble Analogue of Parthenolide LC-1 Influences Apotosis in Bladder Cancer
Cell Lines by Modulating Pro-Apoptotic Genes and promotes p21 Activity”.
Rajasubramaniam Shanmugam, Sundar Neelakantan, Vetrichelvan Jayaprakasan, Peter
A. Crooks, Harikrishna Nakshatri, and Christopher Sweeney, Ninety Seventh Annual
Meeting of the American Association for Cancer Research, Abstract 06-AB-3393-AACR,
Washington, DC, April1st-5th, 2006.
368.
“Synthesis of New Water Soluble Parthenolide Analogs as Potential Antitumor Agents”.
Daneli Lopez, Peter A. Crooks, and Sundar Neelakantan, Proceedings of the 231st
American Chemical Society National Meeting, March 26-30, 2006, Atlanta, GA, Abstract
No. MEDI-292.
369.
“Effects of Novel N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide on Nucleus
Accumbens Dopamine Release in Rats Sensitized to Nicotine”. Shafiq Rahman, Nicole
M. Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T.
Bardo, Sixty Eighth Annual Meeting of the College on Problems of Drug Dependence,
Abstract 45, p5, Scottsdale, AZ, June, 2006.
370.
“Synergistic Design of Polar bis-Pyridinium Analogs Containing a 1,4-Di-(1butynyl)phenylenediyl Linker: Interaction with Both Nicotinic Receptors and the BloodBrain Choline Transporter”. Zhenfa Zhang, A. Gabriela Deaciuc, Paul R. Lockman,
David D. Alllen, Linda P. Dwoskin, and Peter A. Crooks, Sixty Eighth Annual Meeting
of the College on Problems of Drug Dependence, p17, Scottsdale, AZ, June, 2006.
371.
“Novel Trivalent Antagonists with Selectivity for Alpha7 Type Nicotinic Acetylcholine
Receptors”. By Roger L. Papke, Guangrong Zheng, C. J. Burkle, Peter A. Crooks, and
Linda P. Dwoskin, Sixty Eighth Annual Meeting of the College on Problems of Drug
Dependence, Abstract 23, p27, Scottsdale, AZ, June, 2006.
372.
“New Leads for the Treatment of Nicotine Addiction: Discovery of Novel bis-Quaternary
Ammonium Antagonists at Neuronal Nicotinic Receptors Mediating Nicotine-Evoked
Dopamine Release”. Guangrong Zheng, Sangeetha P. Sumithran, A. Gabriela Deaciuc,
Linda P. Dwoskin, and Peter A. Crooks, Sixty Eighth Annual Meeting of the College on
Problems of Drug Dependence, Abstract 24, p27, Scottsdale, AZ, June, 2006.
373.
“New Leads for the Treatment of Nicotine Addiction: Discovery of Novel tris-Quaternary
Ammonium Antagonists at Neuronal Nicotinic Receptors Mediating Nicotine-Evoked
Dopamine Release”. Sangeetha P. Sumithran, Guangrong Zheng, A. Gabriela Deaciuc,
Peter A. Crooks, and Linda P. Dwoskin, Sixty Eighth Annual Meeting of the College on
Problems of Drug Dependence, Abstract 25, p27, Scottsdale, AZ, June, 2006.
374.
“A Novel Orally Available Parthenolide Analog Selectively Eradicates AML Stem and
114
Progenitor Cells”. Monica L. Guzman, Randall M. Rossi, Xiaojie Li, Cheryl Corbett, Duane
C. Hassane, Timothy Bushnell, Martin Carroll, Edmund Sullivan, Sundar Neelakantan,
Peter A. Crooks, and Craig T. Jordan, Forty Eighth Annual Meeting of the American
Society of Hematology, Abstract # 553723, Orlando, FL, December, 2006.
375.
“Nornicotine, the Tobacco Alkaloid and CNS Metabolite of Nicotine, Differentially Activates
Brain Nicotinic Receptors”. Roger L. Papke, Linda P. Dwoskin, and Peter A. Crooks,
Annual Meeting of the Society for Neuroscience, Atlanta, GA, October, 2006;
Neuroscience Abstracts, 2006, 36, Abstract 524.11/C74.
376.
“Lobeline and meso-Transdiene Analogs: Interaction at Neurotransmitter Transporters and
Nicotinic Receptors”. David B. Horton, Marhaba Hojahmat, A. Gabriela Deaciuc, John P.
Culver, Seth D. Norrholm, Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting of the
Society for Neuroscience, Atlanta, GA, October, 2006; Neuroscience Abstracts, 2006, 36,
Abstract 591.1/PP67.
377. “Parthenolide and its Water Soluble Analog LC-1 as Potent Anti-tumor Agents”. Sundar
Neelakantan, Rajasubramaniam Shanmugam, Zhu Wei, Vetrichelvan Jayaprakasan,
Poornima Bhat-Nakshatri, Harikrishna Nakshratri, Christopher J. Sweeney, and Peter A.
Crooks, Fourth Annual Kentucky Lung Cancer Research Program Scientist’s Meeting,
Abstract No. 7, Frankfort, KY, October, 2006,
378. “Facilitated Distribution of the Charged Nicotinic Receptor Antagonist bis-[dodecane-1,12diyl]-3-picolinium Dibromide (bPiDDB) Across the Blood-Brain Barrier”. Paul R. Lockman,
Peter A. Crooks, F. Thomas, Linda P. Ddwoskin, and David D. Allen, Annual Meeting of
the Society for Neuroscience, Atlanta, GA, October, 2006; Neuroscience Abstracts, 2006,
36, Abstract 460.12/EE10.
379. “Determination of Novel Nicotinic Receptor Antagonist Binding to the Blood-Brain Barrier
Choline Transporter: a Potential Mechanism for Brain Entry”. Paul R. Lockman, V. K.
Manda, C. J. Van Der Schyf, J. A. Egbert, Linda P. Dwoskin, Peter A. Crooks, and David D.
Allen, Annual Meeting of the Society for Neuroscience, Atlanta, GA, October, 2006;
Neuroscience Abstracts, 2006, 36, Abstract 460.13/EE11.
380. “Development and Validation of an HPLC Analytical method for the Quantitation of
Nornicotine in Rat Plasma, and its Application to Pharmacokinetic Studies”. Buchi Nalluri,
Zaineb Fahdel, Marhaba Hojahmat and Peter A. Crooks, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract M1010.
381. “A Highly Sensitive Method for 5-Fluorouracil in Plasma and Vitreous Humor by Liquid
Chromatography-Mass Spectrometry”. Ahmad Malkawi, Abeer Al-Ghananeem, and Peter A.
Crooks, Twentieth Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract M1037.
382. “Brain/Plasma Bioavailability of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide
(bPiDDB), a Novel Nicotinic Receptor Antagonist”. Zaineb Albayati, Nicole Neugebauer,
Michael T. Bardo, Linda P. Dwoskin, and Peter A. Crooks, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract M1091.
115
383. “Synthetic Approaches Towards Analogs of Lobeline: Discovery of novel Treatments foe
Psychostimulant Abuse”. Ashish Vartak, Linda P. Dwoskin, and Peter A. Crooks, Twentieth
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2006, San Antonio, TX, Abstract M1093.
384. “Carbonate Ester Prodrugs of 6--Naltrexol for Transdermal Delivery”. Mohamed Hamad,
Audra Stinchcomb, and Peter A. Crooks, Twentieth Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2006, San Antonio, TX,
Abstract M1097. Bristol-Myers Squibb Award for Outstanding Poster Presentation.
385. “Sub-type Selective, Guanylated Nicotine Analogs; Functionally Active Non-competitive
Agonists and Antagonists at the Neuronal Nicotinic Receptor”. Aaron Haubner, John M.
Littleton, Neil Millar, Linda P. Dwoskin, and Peter A. Crooks, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract M1098.
386. “Synthesis, Solubility, and Hydrolytic Stability of Hydroxybupropion Prodrugs”. Mohamed
Hamad, Paul Kiptoo, Audra Stinchcomb, and Peter A. Crooks. Twentieth Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract M1099.
387. “A Water-Soluble Analog of Parthenolide LC-1 as a Potent Anti-tumor Agent”. Sundar
Neelakantan, and Peter A. Crooks, Twentieth Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2006, San Antonio, TX,
Abstract M1104.
388. “Synthesis and Evaluation of a Series of New Water-soluble Aromatic Amine Parthenolide
Analogs as Anti-leukemic Agents”. Shama Nasim, Sundar Neelakantan, Craig Jordan,
Monica Guzzman, and Peter A. Crooks, Twentieth Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2006, San Antonio, TX,
Abstract M1114. Bristol-Myers Squibb Award for Outstanding Poster Presentation.
389. “Synergistic Design of Polar bis-Pyridinium Analogs Containing a Conformationally
Restricted 1,4-Di-(butynyl)phenylenediyl Linker: Interaction with both Nicotinic Receptors
and the Blood-Brain Barrier Choline Transporter”. Zhenfa Zhang, Sangitha Sumithran, A.
Gabriela Deaciuc, Paul R. Lockman, David D. Allen, Linda P. Dwoskin, and Peter A.
Crooks, Twentieth Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract M1116.
390. “Synthesis of Novel Arylideneamino-gaunidine Hydrochlorides as Potential Antagonists of
the N-Methyl-D-aspartate Receptor (NMDAR) Complex”. Thirupathi Yerramreddy,
Vijayakumar Sonar, John M. Littelton, Robert Holley, and Peter A. Crooks, Twentieth
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2006, San Antonio, TX, Abstract M1117.
391. “Prediction of the Affinity of N-n-Alkyl Nicotinium Salts as Antagonists at the α42* Nicotinic
Acetylcholine Receptor (nAChR) Subtype by Computational Neuronal Network Analysis”.
Fang Zheng, A. Gabriela Deaciuc, Guangrong Zheng, Chang-Guo Zhan, Linda P. Dwoskin,
and Peter A. Crooks, Twentieth Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract M1128.
116
392. “Synthesis and Pharmacological Studies on Novel tris-Quaternary Ammonium Salts:
Interaction with Nicotinic Acetylcholine Receptors and Inhibition of Nicotine-Evoked
Dopamine Release”. Guangrong Zheng, Sangeetha Sumithram, Roger L. Papke, Linda P.
Dwoskin, and Peter A. Crooks, Twentieth Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract M1130.
393. “Scopolamine Sublingual Spray: An Alternative Route of Delivery for the Treatment of
Motion Sickness”. Abeer Al-Ghananeem, Ahmad Malkawi, and Peter A. Crooks, Twentieth
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2006, San Antonio, TX, Abstract M1221.
394. “Nasal Delivery of 9-Tetrahydrocannabenol-Loaded Bioadhesive Chitosan Gels in
Rabbits”. Abeer Al-Ghananeem, Ahmad Malkawi, and Peter A. Crooks, Twentieth Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, October,
2006, San Antonio, TX, Abstract M1222.
395. “In Vivo Evaluation of Transdermal Delivery of 6-Beta-Naltrexol Hydrochloride after
Microneedle Treatment of Hairless Guinea Pigs”. Stan Banks, Mohamed Hamad, R.
Pinninti, H. Gill, Peter A. Crooks, amd Audra Stinchcomb, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract M1302.
396. “Absolute Configuration, Resolution and Chiral HPLC Separation of Norketamine
Enantiomers: a Potential Analgesic Agent for Neuropathic Pain”. Marhaba Hojahmat, and
Peter A. Crooks, Twentieth Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract T2003.
397. “In Vitro/In Vivo Correlation of a Transdermal Codrug of 6-Beta-Naltrexol Linked to
Hydroxybupropion in Hairless Guinea Pigs”. Paul Kiptoo, K. Paudel, Donna Hammell,
Mohamed hamad, Peter A. Crooks, and Audra Stinchcomb, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract T2210.
398. “Tablet Formulation Studies on Nimesulide and Meloxicam-Cyclodextrin Binary Systems”.
Buchi Nalluri, C. Kora, R. Murthy, G. Becket, and Peter A. Crooks, Twentieth Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, October,
2006, San Antonio, TX, Abstract T3246.
399. “The Blood-Brain Barrier Choline Transporter Facilitates Brain Entry of the Polar Nicotinic
Receptor Antagonist, bis-[Dodecane-1.12-diyl]-3-picolinium Dibromide (bPiDDB)”. Paul R.
Lockman, Peter A. Crooks, V. Manda, J. Egbert, F. Thomas, Linda P. Dwoskin, and David
D. Allen, Twentieth Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2006, San Antonio, TX, Abstract W5337.
400. “Molecular Modeling of Semi-rigid bis-Quaternary Ammonium Compounds at the BloodBrain Barrier Choline Transporter”. W. Geldenhuys, V. Manda, Paul R. Lockman, J. Egbert,
Peter A. Crooks, Linda P. Dwoskin, and David D. Allen, Twentieth Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2006,
San Antonio, TX, Abstract W5344.
401. “Affinity of Nicotinic Receptor Antagonists for the Blood-Brain Barrier Choline Transporter: a
117
Potential Vector for Brain Access”. V. Manda, J. Egbert, Peter A. Crooks, Linda P. Dwoskin,
David D. Allen, and Paul R. Lockman, Twentieth Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2006, San Antonio, TX,
Abstract W5345.
402. “Lobeline Analogs as Potent and Selective VMAT2 Antagonists”. Peter A. Crooks,
Guangrong Zheng, Agripina G. Deaciuc, and Linda P. Dwoskin, Proceeding of the
45th Annual Meeting of the American College of Neuropsychopharmacology, December,
2006, Hollywood, FL, Neuropsychopharmacology, 2006, 31(Supplement 1), S29.
403.
“NMDA Receptor for Chronic Pain; Can We Do Better than Ketamine?”. By Joseph R.
Holtman, Jr., Peter A. Crooks, J. K. Johnson, and Elzbieta P. Wala, 30th Meeting of the
Midwest Pain Soc, Abstract, June, 2006, Chicago, IL.
404.
“S(-)-Norketamine-Morphine Combination Therapy for Treatment of Neuropathetic
Pain”. By Joseph R. Holtman, Jr., J.K. Johnson, Peter A. Crooks, and Elzbieta Wala,
Annual Meeting of the American Pain Society, Abstract # 768, San Antonio, TX, 2006.
405.
“S(-)-Norketamine Inhibits Morphine and Oxycodone Tolerance in Rats”. By Elzbieta
Wala, W. Griffitn, Peter A. Crooks, and Joseph R. Holtman, Jr., Annual Meeting of the
American Pain Society, Abstract # 764, San Antonio, TX, 2006.
406. “Suppression of Manganese Superoxide Dismutase Induction Reveals a Transcriptionalbased Mechanism for the Selective Radiosensitization of Prostate Cancer Cells by
Parthenolide”. William St. Clair, Yulan Sun, Daret St. Clair, I. Batinic-Haberle, F. Fang, M.
Kudrimoti, Graham Warren, and Peter A. Crooks, Int. J. Radiat. Oncol. Biol. Phys., 2006,
66: S592.
407. “A Pharmacokinetic Study on Z-()-2-(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a Novel Radio-sensitization Agent”. Abeer M. Al-Ghananeem, Zaineb AlBeyati, Ahmad Malkawi, Vijayakumar N. Sonar, Buck Rogers, Michael L. Freeman and
Peter A. Crooks. 7th Joint American Association for Cancer Research – Japanese Cancer
Society Conference; In the Forefront of Basic and Translational Cancer Research,
January, 2007, Kona, HI.
408.
“Brain/Plasma Bioavailability of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide
(bPiDDB), a Novel Nicotinic Receptor Antagonist”. By Zaineb A. Fadhel Albayati, Nichole
Negebauer, Michael T. Bardo, Linda P. Dwoskin, and Peter A. Crooks, International
Scholars Poster Session, Office of International Affairs, University of Kentucky, Abstract
2, page 2, February, 2007, Lexington, KY.
409.
“An HPLC Method for the Simultaneous Determination of Neurotoxic Dipyridyl Isomers in
Human Plasma”. By Ahmad H. Malkawi, Abeer M. Al-Ghananeem, Shama Naseem, Jose
de Leon, and Peter A. Crooks, International Scholars Poster Session, Office of
International Affairs, University of Kentucky, Abstract 23, page 24, February, 2007,
Lexington, KY.
410. “Norketamine in Combination with Morphine for Inflammatory Pain”. J. K. Johnson, Elzbieta
P. Wala, Peter A. Crooks, L. M. Dorfling, and Joseph R. Holtman, Jr., Experimental Biology
Annual Meeting, FASEB Meeting, Abstract 563.6, April, 2007, Washington, DC.
118
411. “Norketamine (NKET) Enantiomers in Combination with Morphine (MOR) for Neuropathic
Pain”. Elzbieta P. Wala, J. K. Johnson, Peter A. Crooks, L. M. Dorfling, and Joseph R.
Holtman, Jr., Experimental Biology Annual Meeting, ASPET Meeting, Abstract No. 563.7,
April, 2007, Washington, DC.
412. “Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a
Mitotic Catastrophe Pathway”. By Konjeti R. Sekhar, Vijayakumar N. Sonar, Venkatraj
Muthusamy, Andrei Laszlo, Joseph L. Roti Roti, Michael L. Freeman, Thirteenth
International Congress of Radiation Research, July, 2007, San Franscisco, CA.
413. “Preclinical Development and Mechanistic Evaluation of Parthenolide and its WaterSoluble Analogue, Dimethylaminoparthenolide (DMAPT) as a New Treatment for
Prostate Cancer”. By Christopher Sweeney; Rajasubramaniam Shanmugam;
Praveen Kusumanchi, Marc Mendonca, Peter A. Crooks, and Harikrishna Nakshatri,
Department of Defence IMPACT Meeting, Atlanta, GA, September, 2007.
414. “Drugability Case Study: Exploration of Structural Modifications and Their Impact on Oral
Bioavailability of Novel Radiosensitization Agents (A): Z-()-2-(1-Benzylindole-3-ylmethylene)azabicyclo[2.2.2]octane-3-ol, (B): Z-()-2-(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-one, (C): Z-()-2-[1-(4-Chlorobenzy)lindole-3-yl-methylene]azabicyclo[2.2.2]octane-3-ol”. By Abeer M. Al-Ghananeem, Zaineb Al-Beyati, Ahmad H.
Malkawi, Michael Freeman, and Peter A. Crooks. Proceedings of the 233rd American
Chemical Society National Meeting, March, 2007, Chicago, IL, Abstract No. MEDI-99.
415. “Synthesis and Evaluation of Quinuclidine-Incorporated Lobelane Analogs as Vesicular
Monoamine Transporter Ligands”. By Guangrong Zheng, Linda P. Dwoskin, Agripina G.
Deaciuc, and Peter A. Crooks, Proceedings of the 233rd American Chemical Society
National Meeting, March, 2007, Chicago, IL, Abstract No. MEDI-267.
416.
“Cytotoxicity of Parthenolide Analogs against Leukemia Cells In Vitro”. By Shama Nasim
and Peter A. Crooks, Proceedings of the 233rd American Chemical Society National
Meeting, March, 2007, Chicago, IL, Abstract No. MEDI-170.
417. “Design and Synthesis of Lobelane Analogs Targetting the Vesicular Monoamine
Transporter (VMAT2) as a Potential Treatment for Methamphetamine Abuse”. John P.
Culver, Agripina G. Deaciuc, Linda P. Dwoskin, and Peter A. Crooks, Proceedings of the
233rd American Chemical Society National Meeting, March, 2007, Chicago, IL, Abstract
No. MEDI-268.
418. “Computational Neural Network Analysis of the Affinity of Lobelane and Tetrabenazine
Analogs for the Vesicular Monoamine Transporter-2”. By Fang Zheng, Guangrong Zheng,
A. Gabriela Deaciuc, Chang-Guo Zhan, Linda P. Dwoskin, and Peter A. Crooks.
Proceedings of the 233rd American Chemical Society National Meeting, March, 2007,
Chicago, IL, Abstract No. MEDI-269.
419. “Design, Synthesis and Pharmacological Evaluation of Novel Analogs of the AntiAddictiveAlkaloid, Lobeline”. By Ashish P. Vartak, Agripina G. Deaciuc, Linda P. Dwoskin,
and Peter A. Crooks, Proceedings of the 233rd American Chemical Society National
Meeting, March, 2007, Chicago, IL, Abstract No. MEDI-454.
119
420. “Targeting Cell Cycle and Apoptopic Machinery of Bladder Cancer Cells Through a Novel
NF-кB inhibitor LC-1”. By Rajasubramanium Shanmugam, Suresh Kumar, Sundar
Neelakantan, Peter A. Crooks, Christopher J. Sweeney, and Harikrishna Nakshatri, Flight
Attendant Medical Research Institute Annual Meeting, May, 2007, Miami, FL, Abstract
No. xxx.
421.
“Structural Evolution of Simple N, N’-Alkylnicotinium Analogs: A Novel Class of Nicotinic
Receptor Agonists Inhibiting Nicotine-Evoked Neurotransmitter Release”. By Peter A.
Crooks, NIDA-Supported National Cooperative Drug Discovery Groups
Symposium. Building Translational Research in Medication Development in Academia:
Issues, Strategies and Tactics, Quebec City, Canada, June, 2007.
422. “Effects of Novel tris-Quaternary Ammonium Nicotinic Antagonists on Locomotor Activity and
Nicotine-Induced Hyperlocomotion in Rats”. By Jason T. Ross, Zhenfa Zang, Guangrong
Zheng, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Sixty Ninth Annual
Meeting of the College on Problems of Drug Dependence, Abstract 22, p78, Quebec City,
Canada, June, 2007.
423. “Paclitaxel-loaded Cross-linked Hyaluronidase Nanoparticles for Breast Cancer Therapy”. By
Abeer M. Al-Ghananeem, Penni Black, Justin M. Balko, jabar Faraj, Ahmad Malkawi,
Patrick DeLuca, Peter A. Crooks, and Edward Romond, Sixteenth International Symposium
on Microencapsulation, Abstract 216, p11, Lexington, KY, September, 2007.
424.
“The Search for More Selective Neuronal Nicotinic Acetylcholine Receptor Antagonists
as Smoking Cessation Agents”. Invited speaker, Symposium on Molecular Diversity in
Drug Design, Discovery and Delivery, University of South Florida, Abstract 13, p20,
Tampa, FL, October, 2007.
425.
“Antinociceptive Effects of Nornicotine in Rodents”. Joseph R. Holtman, peter A. Crooks,
Jamie Johnson, Marhaba Hojhamat, and Elzbieta P. Wala, Annual Meeting of the Society
for Neuroscience, Abstract No. 182.21/009, San Diego, CA, November, 2007.
426.
“A Novel Iminoguanidine Compound, JR-220, Reduces Voluntary Alcohol Consumption
In a Relapse Paradigm and Following Restraint Stress in Rodents”. B. Lewis, J. M.
Farook, K. A. Wellman, Peter A. Crooks, John M. Littleton, and Susan Barron, Annual
Meeting of the Society for Neuroscience, Abstract No. 63.6/X17, San Diego, CA,
November, 2007.
427.
“Novel Vesicular Monoamine Transporter (VMAT2) Inhibitors as Potential Treatments for
Methamphetamine Abuse: 3, 5-Disubstituted Meso-transdiene Analogs of Lobeline” .A.
Gabi Deaciuc, David B. Horton, Marhaba Hojahmat, John P. Culver, Seth D. Norrholm
Peter A. Crooks, and Linda P. Dwoskin. Annual Meeting of the Society for Neuroscience,
Abstract No. 814.4/AA16, San Diego, CA, November, 2007.
428.
“Novel Vesicular Monoamine Transporter (VMAT2) Inhibitors as Potential Treatments for
Methamphetamine Abuse: Constrained Lobeline Analogs Inhibit VMAT2 Binding and
Function”. J. Chagkutip, Ashish P. Vartak, A. Gabi Deaciuc, Peter A. Crooks, and Linda P.
Dwoskin, Annual Meeting of the Society for Neuroscience, Abstract No. 65.2/Y13, San
Diego, CA, November, 2007.
120
429.
“Novel Vesicular Monoamine Transporter (VMAT2) Inhibitors as Potential Treatments for
Methamphetamine Abuse: Interaction of meso-Transdiene and Lobelane Analogs at
Neurotransmitter Transporters”. David B. Horton, Guangrong Zheng, A. Gabi Deaciuc,
Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting of the Society for Neuroscience,
Abstract No. 815.AA17, San Diego, CA, November, 2007.
430.
“Discovery of Novel Nicotinic Receptor Antagonists for the Treatment of Nicotine Addiction:
1-Trimethylammonium-10-[1-(3-picolinium0]decane (TMPD) Inhibits Nicotine-Evoked
Dopamine Release from Rat Striatal Slices and Decreases Nicotine Self-administration”. By
B. Matt Joyce, Guangrong Zheng, J. T. Ross, Michael T. Bardo, Roger L. Papke, Peter A.
Crooks, and Linda P. Dwoskin, Annual Meeting of the Society for Neuroscience, Abstract
No. 781.10, San Diego, CA, November, 2007.
431.
“Investigation of the Selectivity of Phenyl Ring-substituted Lobelane Analogs for VMAT2 in
the Development of Novel Therapies for Methamphetamine Abuse”. By J. R. Nickell, A.
Gabi Deaciuc, Guangrong Zheng, Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting
of the Society for Neuroscience, Abstract No. 65.16/Y27, San Diego, CA, November,
2007.
432.
“Tetrakis Quaternary Ammonium Salts: Novel Nicotinic Receptor Antagonists which Inhibit
Nicotine-evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices”. By
Marharyta Pivavarchyk, Zhenfa Zhang, Peter A. Crooks, and Linda P. Dwoskin, Annual
Meeting of the Society for Neuroscience, Abstract No. 78.12/F12, San Diego, CA,
November, 2007.
433.
“The Identification of Selective Competitive and Noncompetitive nAChR Antagonists Using
Alpha6 Nicotinic Acetylcholine Receptor Chimeras”. By Clair Stokes, Linda P. Dwoskin,
Peter A. Crooks, L. B. Jacobs, J. Michael McIntosh, and Roger L. Papke, Annual Meeting
of the Society for Neuroscience, Abstract No. 574.4/J9, San Diego, CA, November, 2007.
434.
“Pharmacokinetics of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide (bPiDDB), a
Novel Nicotinic Receptor Antagonist”. By Zaineb F. Albayati, Linda P. Dwoskin, Peter A.
Crooks, Twenty First Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, November, 2007, San Diego, CA,
435.
“Synthesis and Evaluation of 3,5-Disubstituted Piperidine Analogs Related to Lobeline as
Vesicular Monoamine Transporter Ligands”. By Marhaba Hojahmat, David B. Horton, A.
Gabi Deaciuc, John P. Culver, Linda P. Dwoskin, and Peter A. Crooks, Twenty First
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2007, San Diego, CA,
436.
“Prediction of Channel Blocking Effect of 5-n-Alkyloctahydro Indolizine Analogs at the
α4β2* nAChR Subtype”. By Fang Zheng, X. Huang, Linda P. Dwoskin, Chang-Guo Zhan
and Peter A. Crooks, Twenty First Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2007, San Diego, CA,
437.
“Synthesis and Evaluation of Homologous Analogs of Lobelane at the Vesicular Monamine
Transporter (VMAT2)”. By Guangrong Zheng, Linda P. Dwoskin, A. Gabi Deaciuc, and
Peter A. Crooks. Twenty First Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
121
438.
“Tetrakis-quaternary Ammonium salts: Novel bPiDDB Analogs as Selective Neuronal
Nicotinic Receptor Antagonists for Subtypes Mediating Nicotine-evoked Dopamine
Release”. By Zhenfa Zheng, Maharyta Pivavarchyk, A. Gabi Deaciuc, Linda P.
Dwoskin, Peter A. Crooks, Twenty First Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
439.
“Synthesis and Evaluation of a Series of Acrylonitriles as Polyamine Site Antagonists at
the NMDA Receptor Complex”. By Vijayakumar N. Sonar, Robert Holley, John H.
Littleton, and Peter A. Crooks, Twenty First Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
440.
“Synthesis of Novel Substituted (Z)-2-(N-Benzylindol-3-ylmethylene)-quinuclidin-3-one and
(Z)-2-(N-Benzylindol-3-ylmethylene)-quinuclidin-3-ol Derivatives as Potent
Radiosensitizing Agents”. By Vijayakumar N. Sonar, Thirupathi R. Yerramreddy,
Rajasekhar Konjeti, Michael Freeman, and Peter A. Crooks, Twenty First Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2007, San Diego, CA.
441.
“Design and Synthesis of Bone-Targeted Analogs of Estradiol for Osteoporosos”. By
Shama Nasim, Grant Taylor, William Pierce, and Peter A. Crooks, Twenty First Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2007, San Diego, CA.
442.
“Local Perfusion of the Novel Nicotinic Receptor Antagonist N,N-dodecane-1,12-diyl-bis-3picolinium Dibromide (bPiDDB) into the Ventral Tegmental Area (VTA) or the Nucleus
Accumbens (NAcc), differentially regulates Nicotine-Induced Increases in Extracellular
Dopamine”. By Shafiq Rahman, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and
Michael T. Bardo, Twenty First Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
443.
“Extraction and Quantitation of Parthenolide from Tancetum Parthenium (feverfew plant),
Followed by Direct Derivitization to the Antitumor Drug, LC-1”. By Sundar Neelakantan and
Peter A. Crooks, Twenty First Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, October, 2007, San Diego, CA.
444.
“Synthesis of Lobeline Analogs Targeting the Vesicular Mononamine transporter-2
(VMAT2)”. By John P. Culver, Agripina Deaciuc, Linda P. Dwoskin, and Peter A. Crooks,
Twenty First Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2007, San Diego, CA.
445.
“A Pharmacokinetic Study on Z-(-2-(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]
octane-3-ol; a Novel Radiosensitization Agent”. By Abeer M. Al-Ghananeem, Ahmad H.
Malkawi, Zaineb Al-Beyati, Vijayukumar N. Sonar, Michael Freeman, and Peter A. Crooks
Twenty First Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, October, 2007, San Diego, CA.
446.
“In Vitro Human Skin Permeation: Effects of Bioconversion and Moleculer Weight”. By Paul
K. Kiptoo, Peter A. Crooks, and Audra L. Stinchcomb, Twenty First Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, October, 2007, San
Diego, CA.
122
447. “Simultaneous Determination of Nitrogen Mustard [2-Chloro-N-(2-chloroethyl)-N-methylethanamine] and its Potential Half Mustard metabolite, [2-Hydroxy-N-(2-chloroethyl)-Nmethyl-ethanamine] in Human Blood”. By Vipin P. Nair, and Peter A. Crooks, Twenty First
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
October, 2007, San Diego, CA.
448. “An HPLC Method for the Simultaneous Determination of Neurotoxic Dipyridyl Isomers in
Human Plasma”. By Ahamd H. Malkawi, Shama Naseem, Abeer M. Al-Ghananeem, Jose
de Leon, and Peter A. Crooks, Twenty First Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
449. “Does the Use of Warmed Water for Injection Accelerate the Reconstitution of the Sparingly
Water-Soluble Drug Dantrolene Sodium?”. By Abeer M. Al-Ghananeem, Ahmad H.
Malkawi, George A. Digenis, Patrick P. Deluca, and Peter A. Crooks, Twenty First Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, October,
2007, San Diego, CA.
450. “Kinetic Studies on Dantrolene Sodium”. By Abeer M. Al-Ghananeem, Ahmad H.
Malkawi, George A. Digenis, Patrick P. Deluca, and Peter A. Crooks, Twenty First Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, October,
2007, San Diego, CA.
451. “Development and Validation of a Liquid Chromatography/Tandem Mass Spectrometry
(LC/MS/MS) Method for the Determination of the Novel Radiosensitization Agent: Z-()-2(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol (BMABO)”. By Abeer M. AlGhananeem, Ahmad H. Malkawi, Vijayukumar N. Sonar, John May, Buck Rogers, and
Peter A. Crooks, Twenty First Annual Meeting and Exposition of the American Association
of Pharmaceutical Scientists, October, 2007, San Diego, CA.
452. “Effect of Oral Norketamine in the Rat Formalin Pain Model”. By Joseph Holtman, Jr., Jaime
Johnson, Lize-Mari Dorfling, Marhaba Hojahmat, Mark Klevin, and Peter A. Crooks,
Twenty First Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, October, 2007, San Diego, CA.
453.
“Differential Inhibition of Ach-evoked Responses of Neuronal Nicotinic Receptors in Rat
Brain Slices by Selective nAChR Antagonists”. By G. Y. Lopez, J. S. Thinschmidt,
Guangrong Zheng, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Roger L.
Papke, Satelite Meeting, Twenty First Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, October, 2007, San Diego, CA.
454. “NMDA Receptor Antagonists for Pain-Can We Do Better Than Ketamine?” By Joseph L.
Holtman, Jr., Peter A. Crooks, Jamie K. Jameson, and Elzbieta P. Wala, Postgraduate
Assembly in Anesthesiology, New York State Society of Anesthesiologists, December, 2007,
New York, NY.
455. “The NF-B-PTEN Axis Enhances Radiation Sensitivity of Prostate Cancer Cells”. William
St. Clair, Yulan Sun, Daret St. Clair, F. Fang, Graham Warren, V. Rangnekar, and Peter A.
Crooks, Int. J. Radiat. Oncol. Biol. Phys. Abstract 2007, 69: S611.
456.
“Opioid Combination Drug Therapy for Neuropathic Pain”. By Joseph R. Holtman, Jr., Peter
A. Crooks, Jaime K. Johnson, Marhaba Hojahmat, and Elzbieta P. Wala, American
123
Academy of Pain Medicine: Twenty Fourth Annual Meeting, Abstract xxx, February, 2008,
Orlando, FL.
457.
“A Water-soluble Analogue of Parthenolide has Anti-Cancer In Vitro and In Vivo Activity by
Generation of Reactive Oxygen Species and Inhibition of Nuclear Factor Kappa B. By
Christopher Sweeney, R. Shanmugam, P. Kusumanchi, Sundar Neelakantan, William
Matthews, Craig T. Jordan. Peter A. Crooks, and Harikrishna Nakshatri, The Genitourinary
Cancers Symposium, an ASCO, ASTRO and SUO Co-sponsored Symposium, Abstract 08AB-202292-ASCOGU, February, 2008, San Franscisco, CA.
458. “Water-Soluble Parthenolide Analog LC-1 as a Potent Anti-tumor Agent”. By Sundar
Neelakantan, Rajasubramaniam Shanmugam, Vetrichelvan Jayaprakasan, Harikrishna
Nakshatri, Christopher J. Sweeney, and Peter A. Crooks, Fifth Annual Meeting of the
Kentucky Lung Cancer Research Program (KLCRP), February, 2008, Frankfort, KY.
459.
“An Orally Bioavailable Parthenolide Analogue Inhibits Both Subcutaneous and
Metastatic Xenograft Growth in Lung and Bladder Cancer Cell Lines and is Independent
of p53 Status”. By Rajasubramaniam Shanmugam, Praveen Kusumanchi, Peter A.
Crooks, James Klaunig, Craig T. Jordan, Harikrishna Nakshatri, and Christopher
Sweeney, Annual Meeting of the American Association for Cancer Research, April,
2008, San Diego, CA
460.
“Dimethylaminoparthenolide (DMAPT) Anti-cancer Activity is Mediated by ROS
Generation and Inhibition of Nuclear Factor κ B”. By Praveen Kusumanchi,
Rajasubramaniam Shanmugam, Peter A. Crooks, Craig T. Jordan,
Harikrishna Nakshatri, and Christopher Sweeney, Annual Meeting of the American
Association for Cancer Research, April, 2008, San Diego, CA.
461.
“LC-1: A Water Soluble Parthenolide Analog and Potent Anti-tumor Agent can be
Isolated Directly from Tanacetum parthenium (feverfew) Green Plant”. By Sundar
Neelakantan, Maelor Davies, Orlando Chambers, William Mathews, and Peter A.
Crooks, Sixth Annual Ohio Valley Affiliates for Life Sciences (OVALS) Symposium,
Transformational Research: A Bridge to Building Economies, Louisville, KY, April, 2008
(Award for Outstanding Poster Presentation).
462.
“Oral Efficacy of S-Norketamine in Preclinical Rodent Pain Models”. By Joseph R. Holtman,
Peter A. Crooks, Mark S. Klevin, Marhaba Hojahmat, Jamie K. Johnson, Katelyn Etscheidt
and Elzbieta P. Wala, Twenty Seventh Annual Meeting of the American Pain Society, May,
2008,Tampa, FL.
463.
“DMAPT (LC-1), Parthenolide Analogue, as Epigenetic Therapy for Bladder Cancer”. By
Nikhail R. Collins, Praveen Kusumanchi, Rajasubramanium Shamugam, Sunil Badve,
Sundar Neelakantan, Peter A. Crooks, Christopher J. Sweeney, and Harikrishna
Nakshatri, Flight Attendant Medical Research Institute Annual Meeting, May, 2008,
Boston, MA, Abstract No. 895.
464.
“LC-1: A Synthetic Water-soluble Parthenolide Analog and Potent Anti-tumor
Agent can be Obtained Directly from Tanacetum parthenium (Feverfew) Green Plant”.
By Sundar Neelakantan, Maelor H. Davies, Orlando D. Chambers, and Peter A.
Crooks, Thirty Fifth Annual MALTO Conference, University of Arkansas for Medical
Sciences, Little Rock, AR, May, 2008.
124
465.
“Oral Bioavailability and Pharmacokinetics of N,N’-Dodecane-1,12-diyl-bis-3-picolinium
Dibromide (bPiDDB), a Novel Nicotinic Receptor Antagonist, in Rats”. By Zaineb A.
Fadhel Albayati, Linda P. Dwoskin and Peter A. Crooks, Thirty Fifth Annual MALTO
Conference, University of Arkansas for Medical Sciences, Little Rock, AR, May, 2008.
466.
“GC-NPD-MS Dual Detection for Stability Profiling of a Nitrogenous Drug in a Topical
Formulation”. Vipin D. P. Nair, Nicole Henderson, David R. Worthen, Peter A. Crooks,
Roger Buchanan and Robyn Hannigan, Pharmforum ’08; 7th Annual Southern Regional
Discussion Group Meeting, University of Arkansas for Medical Sciences, Little Rock, AR,
May, 2008.
467. “Inhibition of Nicotine-evoked Dopamine Release from Superfused Rat Striatal Slices by
Novel Quaternary Ammonium Salts Containing an N-5-(3-Biphenyl)pentyl-1-yl
Substituent”. By Peter A. Crooks, Guangrong Zheng, Marharyta Pivavarchyk, and Linda
P. Dwoskin, 70th Annual Meeting of the College on Problems of Drug Dependence, Abstract
No. 87, p14, San Juan, Puerto Rico, June, 2008.
468. “Effects of the Novel Nicotinic Acetylcholine Receptor Antagonist, N,N’-Decane-1,10-diyl-bis3-picolinium Diiodide (bPiDI), on Nicotine Self-administration and Food-maintained
Responding in Rats”. By Tim Wooters, John T. Ross, Zhenfa Zhang, Peter A. Crooks, Linda
P. Dwoskin, and Michael T. Bardo, 70th Annual Meeting of the College on Problems of Drug
Dependence, Abstract No.75, p13, San Juan, Puerto Rico, June, 2008.
469. “Indolizidine 235B’ Potently Inhibits Nicotine-evoked Dopamine Release from Superfused
Rat Striatal Slices”. By Linda P. Dwoskin, Marharyta Pivavarchyk, Hiroshi Tsuneki,
Naoki Toyooka, Zhenfa Zhang, Peter A. Crooks, 70th Annual Meeting of the College on
Problems of Drug Dependence, Abstract No. 86, p14, San Juan, Puerto Rico, June, 2008.
470. “The Novel NMDA Receptor Modulator JR220 is Positive in an Entire Anti-relapse
Screening Hierarchy”. By John M. Littleton, Peter A. Crooks, Joshua Ring, Vijayakumar
N. Sonar, and Susan Barron, Joint Meeting of the Research Association on Alcoholism
and the International Society for Biomedical Research on Alcoholism, June, 2008,
Washington DC.
471.
“Differential Inhibition of Nicotinic Responses in the Ventral Temental Area by SubtypeSelective Antagonists” By Gretchen Y. López-Hernández, Jeffrey S. Thinschmidt, Linda
Cortés, Clare Stokes, Peter A. Crooks, Linda P. Dwoskin, and Roger L. Papke. XIII
International Symposium on Cholinergic Mechanisms. Neuronal and Non-Neuronal
Cholinergic Systems: Molecular and Translational Significance, August, 2008, Foz do
Iguaçu, Brazil, Abstract No. xxx.
472. “Opiod-Nicotinic Antinociceptive Interactions in Rodent Pain Models”. By Joseph R.
Holtman, Jr., Peter A. Crooks, Jamie K. Johnson, Marhaba Hojhamat, and Elzbieta P.
Wala, World Congress on Pain 2008, August, 2008, Glasgow, Scotland.
473. “Use of Gas Chromatography-Nitrogen/Phosphorus Detection-Mass Spectroscopy Dual
Detection in the Stability Profiling of a Nitrogenous Drug in an Aqueous Gel Formulation”.
By Vipin D. P. Nair, Nicole Henderson, David R. Worthen, Peter A. Crooks, Roger
Buchanan and Robyn Hannigan, Proceedings of the 235th American Chemical Society
National Meeting, Abstract No. ANYL-098, August, 2008, Philadelphia, PA.
474. ”Radiation-mediated Tumor Control Using (Z)-2-(1-benzylindol-3-ylmethylene)-1-
125
azabicyclo[2.2.2]octane-3-ol to Target Endothelial Cell proliferation and Morphogenesis”.
By Ling Geng, Girish Rachakonda, D. James Morre, Peter A. Crooks, Vijayakumar N.
Sonar, Joseph L. Roti Roti, Buck Rogers, Suellan Greco, Soumya Sasi, Michael L.
Freeman, and Konjeti R. Sekhar, 54th Annual Meeting of the Radiation Research
Society (RRS) in conjunction with the American Society for Therapeutic Radiology and
Oncology (ASTRO), September, 2008, Boston, MA.
475. “JR220, A Novel Polyamine Antagonist, Reduces Ultrasonic Vocalization Deficits In Infant
Rat Pups Following “3RD Trimester” Ethanol Exposure”. By Kristen A. Wellmann, B.
Lewis, A.H. Kehrberg, M. Carter, John M. Littleton, Peter A. Crooks, and Susan Barron,
Joint Meeting of the International Society for Biomedical Research on Alcoholism (ISBRA)
and the Research Society on Alcoholism (RSA), Washington DC, June, 2008.
476. “A Novel Compound, JR-220, Reduces Ethanol Withdrawal-induced Neurotoxicity in
Organotypic Hippocampal Slice Cultures. By A. Hutton Kehrberg, L. Carter, K. A.
Wellmann, Mark A. Prendergast;,Peter. A. Crooks, John M. Littleton, and Susan Barron,
Annual Meeting of the Society for Neuroscience, Abstract 315.5/AA15, Washington, DC,
November, 2008.
477. “A Novel Compound, JR-220, Reduces Voluntary Alcohol Consumption in a Limited-Access
"Drinking in the Dark" Paradigm”. By B. Lewis, J. M. Farook, K. Wellmann, Peter A. Crooks,
John M. Littleton, and Susan Barron, Annual Meeting of the Society for Neuroscience,
Abstract 257.16/Z33, Washington, DC, November, 2008.
478. “JR-220, A Novel Compound, Reduces Spatial Memory Deficits in Adolescent Rat
Pups Following “3RD Trimester” Ethanol Exposure”. By K.A. Wellmann, B. Lewis, A.H.
Kehrberg, M. Carter, L. Carter, John M. Littleton1, Peter A. Crooks, and Susan Barron,
Annual Meeting of the Society for Neuroscience, Abstract 158.7/DD28, Washington, DC,
November, 2008.
479. “Effects of bis-3-Picolinium Nicotinic Receptor Antagonists on Somatic Indices of
Withdrawal in Nicotine-dependent Rats: Comparison to Mecamylamine”. By Thomas E.
Wooters, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Annual
Meeting of the Society for Neuroscience, Washington, DC, November, 2008.
480. “Differential Inhibition of Nicotinic Responses in the Ventral Tegmental area by nAChR
Subtype-selective Antagonists”. By G. Y. López, J. S. Thinschmidt1, L. Cortés1, Claire
Stokes1, Peter A. Crooks, Linda P. Dwoskin, and Roger L. Papke, Annual Meeting of the
Society for Neuroscience, Abstract No. 328.13/C43, Washington, DC, November, 2008.
481. “tkPIQB Inhibits Nicotine-evoked [3H]Dopamine Release from Rat Striatal Slices via
Surmountable Allosteric Antagonism of 62-Containing Nicotinic Receptors”. By
Marharyta Pivavarchyk, Zhenfa Zhang, J. Michael McIntosh, Peter A. Crooks and Linda
P. Dwoskin, Annual Meeting of the Society for Neuroscience, Abstract 328.15/C45,
Washington, DC, November, 2008.
482. “Water-soluble Analogs of Lobelane as Novel Vesicular Monoamine Transporter (VMAT2)
Inhibitors and Potential Treatments for Methamphetamine Abuse.” By David B. Horton*,
Guangrong Zheng, K. B. Siripurapu, A.Gabi Deaciuc, Peter A. Crooks, and Linda P.
Dwoskin, Annual Meeting of the Society for Neuroscience, Abstract 660.5/GG24,
Washington, DC, November, 2008.
126
483. “N,N’-Dodecane-1,12-diyl-bis-3-picolinium dibromide Inhibits Nicotine-evoked
Norepinephrine Release Through an Allosteric Mechanism of Action”. By
Andrew M. Smith, G. K. Dhawan, Zhenfa Zhang, Peter A. Crooks, and Linda P. Dwoskin,
Annual Meeting of the Society for Neuroscience, Abstract 258.12/AA15, Washington, DC,
November, 2008.
484. “Development of Lobelane Isomers Targeting the Vesicular Monoamine Transporter-2
(VMAT2)”. By John P. Culver, Linda P. Dwoskin, A. Gabi Deaciuc, J. Chagkutip, and Peter
A. Crooks, Twenty Second Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. R6126, p141, November, 2008, Atlanta, GA.
485. “Microneedle-enhanced Transdermal Delivery of Naltrexone Prodrugs”. By Mikolaj
Milewski, Y. Thirupathi Reddy, Harvinder S. Gill, Mark R. Prausnitz, Peter A. Crooks,
Audra L. Stinchcomb, Twenty Second Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, Abstract No. T3057, p103, November, 2008,
Atlanta, GA.
486. “Stability-Indicating HPLC Method for an Oral Formulation of the Novel Anti-Tumor Agent
LC-1.” By Sundar Neelakantan and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. W5027,
p126, November, 2008, Atlanta, GA.
487. “Synthesis of Novel Substituted N-Benzyl Alysinopsin Analogs as Potent Radio-sensitizing
Agents”. By Narsimha Reddy Penthala, Thirupathi Reddy Yerramreddy, Konjeti R. Sekhar,
Michael L. Freeman, and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. R6076,
p140, November, 2008, Atlanta, GA.
488. “Design and Synthesis of Novel 3-O-Pegylated Carboxylated and 3-O-Pegylated Carbamate
Naltrexone Prodrugs for Transdermal Delivery”. By Thirupathi Reddy Yerramreddy, Mikolaj
Milewski, Audra L. Stinchcomb, and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. R6085,
p140, November, 2008, Atlanta, GA.
489. “Preclinical Pharmacokinetic Evaluation of Z-()-2-(1-Benzenesulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one (BSAO); a Novel Radio-sensitization Agent” By
Abeer M. Al-Ghananeem, Ahmad H Malkawi, Zaineb F Al-Beyati, Michael L. Freeman,
Peter A. Crooks, Twenty Second Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, Abstract No. T3239, p108, November, 2008,
Atlanta, GA.
490. “Studies on the Interaction of Mechlorethamine Hydrochloride with Topical Excipients”. By
Vipin D. P. Nair, David R. Worthen and Peter A. Crooks, Twenty Second Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, Abstract No.
M1179, p83, November, 2008, Atlanta, GA.
491.
“Simultaneous Determination of Mechlorethamine HCl Nitrogen and a Proposed
Monohydroxyl Degradant in a Model Topical Formulation”. By Vipin D. P. Nair, David R.
Worthen and Peter A. Crooks, Twenty Second Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, Abstract No. W5025, p1127,
November, 2008, Atlanta, GA.
127
492. “An Improved Synthesis of Bone-Targeted Analogs of Estradiol”. By Shama Nasim, William
M. Pierce, K. Grant Taylor and Peter A. Crooks, Twenty Second Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, Abstract No.
R36075, p140, November, 2008, Atlanta, GA.
493. “Stability of Mechlorethamine HCl Nitrogen Mustard in Diethylene Glycol Monoethyl Ether”.
By David R. Worthen, Vipin D. P. Nair and Peter A. Crooks, Twenty Second Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Abstract No. T3083, p104, November, 2008, Atlanta, GA.
494. “A Novel Drug Hybrid of Codeine and S-(-)-Nornicotine as a Potent Analgesic”. By Ujjwal
Chakraborty, Joseph R. Holtman, Elzbieta P. Wala and Peter A. Crooks, Twenty Second
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Abstract No. R6070, p139, November, 2008, Atlanta, GA.
495. “Preparation of a Synergistic Codrug of Codeine and Δ9-THC as a Potent Antinociceptive
Agent”. By Harpreet K. Dhooper, Joseph Holtman and Peter A. Crooks, Twenty Second
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Abstract No. R6071, p139, November, 2008, Atlanta, GA.
496. “Pharmacological Mimickry of Lobelane by Substituted Pyrrolidines in the Inhibition of of the
Vesicular Monoamine Transporter 2 (VMAT2)”. By Ashish P. Vartak, Jaturaporn Chagkutip,
Agripina G. Deaciuc, Linda P. Dwoskin and Peter A. Crooks, Twenty Second Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, Abstract
No. W5067, p128, November, 2008, Atlanta, GA.
497. “A Novel, Practical, Enantioselective Synthesis of (+)- and (-)-Lofexidine”. By Ashish P. A.
Vartak, Abeer Al-Ghananeem, George A. Digenis and Peter A. Crooks, Twenty Second
Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists,
Abstract No. R6099, p140, November, 2008, Atlanta, GA.
498. “Nicotine Exposure can be Detected in Cerebrospinal Fluid of Active and Passive Smokers,
Including Infants and Neonates of Smoking Mothers”. By Ahmad H Malkawi, Abeer M. AlGhananeem, Jose de Leon, and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. M1026,
P78, November, 2008, Atlanta, GA.
499. “Brain/Plasma Bioavailability and Protein Binding Behavior of N,N’-Dodecane-1,12-diyl-bis3-picolinium Dibromide (bPiDDB), a Novel Nicotinic Receptor Antagonist”. By Zaineb A.
Fadhel Albayati, Linda P. Dwoskin, and Peter A. Crooks, Twenty Second Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, Abstract No.
W5050, p127, November, 2008, Atlanta, GA.
500. “Biotinylated 2,4-Disubstituted 1,2,4-thiadiazolidine-3,5-diones as Mechanistic Probes for
the Study of TDZD-mediated Leukemia-Specific Cell Death”. By Shama Nasim, Monica L.
Guzman, Craig T. Jordan and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. W5058,
p127, November, 2008, Atlanta, GA.
501. “Synthesis and Hydrolysis Studies of a (-)-Cytisine-Naltrexone Carbamate Codrug for
Transdermal Drug Delivery”. By Joshua A. Eldridge, Audra L. Stinchcomb and Peter A.
Crooks, Twenty Second Annual Meeting and Exposition of the American Association of
128
Pharmaceutical Scientists, Abstract No. R6072, p139, November, 2008, Atlanta, GA.
502. “Synthesis and Antileukemic Activities of 2,4-Disubstituted 1,2,4-Thiadiazolidine-3,5-dione
Analogs”. By Shama Nasim, Monica L. Guzman, Craig T. Jordan and Peter A. Crooks,
Twenty Second Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. W5059, p128, November, 2008, Atlanta, GA.
503. “The Environmental Pollutant 2, 2’ Dipyridyl is Present in the Plasma of Healthy Human
Volunteers”. By Ahmad H Malkawi, Abeer M. Al-Ghananeem, Jose de Leon, and Peter A.
Crooks, Twenty Second Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. M1027, p78, November, 2008, Atlanta, GA.
504. “Synthesis and Evaluation of a Series of Acrylonitrile Analogs as Antitumor Agents”. By
Vijayakumar N. Sonar, and Peter A. Crooks, Twenty Second Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. R6125,
p141, November, 2008, Atlanta, GA.
505. “Synthesis and Pharmacological Evaluation of N-Substituted Lobelane Analogs at the
Vesicular Monoamine Transporter (VMAT2)”. By Guangrong Zheng, David B. Horton,
Agripina G. Deaciuc, Linda P. Dwoskin, Peter A. Crooks, Twenty Second Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, Abstract No.
R6133, p141, November, 2008, Atlanta, GA.
506. “Synergystic Design of Polar bis-Pyridinium Analogs Containing a Conformationally
Restricted Linker Unit with Activity at Both Nicotinic Receptors and the Blood-brain Choline
Transporter (BBBCT)”. By Zhenfa Zheng, Linda P. Dwoskin, and Peter A. Crooks, Twenty
Second Annual Meeting and Exposition of the American Association of Pharmaceutical
Scientists, Abstract No. R6132, p141, November, 2008, Atlanta, GA.
507. “Dimethylaminoparthenolide (DMAPT) in Multiple Myeloma”. By Colin D. Crean, Genglin
Zhang, Karen E. Pollok, Anthony L. Sinn, Peter A. Crooks, Sherif Farag, and Attaya
Suvannasankha, Fifitieth American Society of Hematology Meeting and Exposition,
Abstract No. 14001, San Francisco, CA, December, 2008.
508. “Decamethonium Analogs as Brain Deliverable Neuronal Nicotinic Acetylcholine Receptor
Antagonists for Nicotinic Addiction”. Invited speaker, Fourteenth International
Pharmaceutical Technology Symposium: Overcoming Biological Barriers in Innovative
Delivery Systems, Abstract pp 41-42, Antalya, Turkey, September, 2008.
509. “Effect of the Lobeline Analog AV-1-228 on Methamphetamine Self-administration
in Rats”. By Josh Beckmann, Emily Denehy, Ashish Vartak, Peter A. Crooks, Linda
P. Dwoskin and Michael T. Bardo, Southeastern Association for Behavior Analysis
Conference, Atlanta, GA, 2008.
510. “Design and Synthesis of Novel Water-soluble Amino and AminoPhosphonate Derivatives
of Parthenolide as Posiible Anti-leukemic Agents”. By Nikhil Reddy Madadi, Thirupathi
Reddy Yerramreddy, and Peter A. Crooks, National Symposium on Recent Trends in
Organic and Medicinal Chemistry, Abstract #1, National Institute of Technology, Warangal,
India, January, 2009.
511. “Dipyridine Cobalt Chloride as a Mild and Efficient Catalyst for the One-Pot Synthesis of 3,4Dihydropyrimidine-2(1H)-ones under Solvent-free Conditions”. By B. Suresh Kuarm, S.
Vijaya Laxmi, J. Venu Madhav, B. Rajitha, Y. Thirupathi Reddy, and Peter A. Crooks,
National Symposium on Recent Trends in Organic and Medicinal Chemistry, Abstract #22,
129
National Institute of Technology, Warangal, India, January, 2009.
512. “Synthesis and Anticonvulsant Activity of Novel Substituted (Z)-5-((N-Benzyl-1H-indol-3-yl)
methylene)imidazolidine-2,4-diones and 5-((N-Benzyl-1H-indol-3-yl)methylene)pyrimidine2,4,6 (1H, 3H, 5H)-triones”. By Thirupathi Reddy Yerramreddy, Narsimha Reddy Penthala,
James P. Stables, and Peter A. Crooks, National Symposium on Recent Trends in
Organic and Medicinal Chemistry, Abstract #32, National Instute of Technology, Warangal,
India, January, 2009.
513. “Synthesis of Novel Substituted N-Benzyl Indolyl Barbiturates as Potential Radio-Sensitizing
Agents”. By Thirupathi Reddy Yerramreddy, Narsimha Reddy Penthala, Konjeti R. Sekhar,
Michael L. Freeman, and Peter A. Crooks, National Symposium on Recent Trends in
Organic and Medicinal Chemistry, Abstract #57, National Institute of Technology,
Warangal, India, January, 2009.
514. “Using the Principles of Hyperthermia to Design Small Molecule Radiation Sensitizers”. By
Konjeti R. Sekhar, Vijayakumar N. Sonar, Thirupathi R. Yerramreddy, Narsimha R.
Penthala, Peter A. Crooks, and Michael L. Freeman, Annual Meeting of the Society for
Thermal Medicine, Tucson, Arizona, April, 2009.
515. “Novel Opioid-Nicotinic Combination Drug Therapy for Pain”. By Joseph R. Holtman Jr.,
Peter A. Crooks, Jaime Johnson-Hardy, Ujjwal Chakraborty, and Elzbieta P. Wala, Twenty
Eighth Annual Meeting of the American Pain Society, San Diego, CA, May, 2009.
516.
“An Epigenetics Therapy for Bladder Cancer”. By Nikhail R. Collins, Christopher
Sweeney, Craig T. Jordan, By Peter A. Crooks, Sundar Neelakantan, William Matthews,
and Harikrishna Nakshatri, Flight Attendant Medical Research Institute Annual Meeting,
May, 2009, Boston, MA, Abstract No. 895.
517. “Brain/Plasma Bioavailability of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide
(bPiDDB) and N,N′-Decane-1,10-diyl-bis-3-reduced-picolinium Hydrochloride (GZ541a),Two Novel Nicotinic Receptor Antagonists, in Rats. By Zaineb A.
Fadhel Albayati, Thomas E. Wooters, Michael T. Bardo, Linda P. Dwoskin and Peter A.
Crooks, Thirty Sixth Annual MALTO Conference, University of Memphis, College of
Pharmacy, Memphis, TN, May, 2009.
518.
“Influence of pH on the Stability of Naltrexone Prodrugs Designed for Transdermal Delivery
Using Microneedles”. By Priyanka Ghosh, Mikolaj Milewski, Yerramreddy T. Reddy, Peter
A. Crooks and Audra L. Stinchcomb, Gordon Conferences, June, 2009, NH.
519.
“Lobelane Analogs with Varying Methylene Linker Lengths as Novel Ligands for
the Vesicular Monoamine Transporter-2”. By Zheng Cao, Guangrong Zheng, A.
Gabi Deaciuc, Peter A. Crooks, and Linda P. Dwoskin, Post-graduate Student Research
Meeting, Purdue University, IN, June, 2009.
520. “JR220, A Novel Compound, Reduces Social, Locomotor, Balance and Memory Deficits in
Rats Following “3rd Trimester” Ethanol Exposure”. By Kristen A. Wellman, B. Lewis, L.
Carter, A. Hutton Kehrberg, John M. Littleton, Peter A. Crooks, and Susan Barron, 2009
Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, CA, June,
2009. Winner of the Gordis Award for best poster presentation.
521. “Indolyl-quinuclidinols Inhibit ENOX Activity and Endothelial Cell Morphogenesis while
Enhancing Radiation-mediated Control of Tumor Vasculature”. By Ling Geng, Girish
130
Rachakonda, D. James Morre, Dorothy M. Morre, Peter A. Crooks, Vijayakumar N.
Sonor, Joseph L. Roti Roti, Buck E. Rogers, Fei Ye, Michael L. Freeman, Konjeti R.
Sekhar, 55th Annual Meeting of the Radiation Research Society, Savannah, GA, October,
2009.
522.
“GZ556A and ZZ204G are Novel Small Molecule Antagonists of α9α10 nAChRs and are
Analgesic in rats”. By J. Michael McIntosh, Jr., Linda P. Dwoskin, Peter A. Crooks, and
Joseph R. Holtman, Nicotinic Acetylcholine Receptors as Therapeutics Targets: Emerging
Fronitiers in Basic Research and Clinical Science: Satellite Meeting, Annual Meeting of the
Society for Neuroscience, Abstract 4.5, Biochemical Pharmacology, 2009, 78, 921,
Chicago, IL, October, 2009.
523.
“Inhibition of Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Strital Slices By
Tertiary Amino Analogs”. By Marharyta Pivavarchyk, Guangrong Zheng, J. Michael
McIntosh, Peter A. Crooks, and Linda P. Dwoskin, NIDA Satellite Symposium. Nicotinic
Acetylcholine Receptors as Therapeutic Targets: Emerging Fronitiers in Basic Research
and Clinical Science. Annual Meeting of the Society for Neuroscience, October, 2009,
Chicago, IL.
524.
“Discovery of Two Novel Subtype-Selective Nicotinic Receptor Antagonists with Potential as
Smoking Cessation Therapeutics”. By Andrew M. Smith, Marharyta Pivavarchyk, Tom E.
Wooters, Zhenfa Zhang, Guangrong Zheng, J. Michael McIntosh, Peter A. Crooks, Michael
T. Bardo, and Linda P. Dwoskin, NIDA Satellite Symposium. Nicotinic Acetylcholine
Receptors as Therapeutic Targets: Emerging Fronitiers in Basic Research and Clinical
Science. Annual Meeting of the Society for Neuroscience. October, 2009, Chicago, IL
525.
“N-Substituted Methamphetamine Derivatives as Novel Vesicular Monoamine Transporter
(VMAT2) Inhibitors”. By David B. Horton, Guangrong Zheng, Joshua S. Beckmann, A. Gabi
Deaciuc, Michael T. Bardo, Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting of the
Society for Neuroscience; Abstract 554.6/AA6, October, 2009, Chicago, IL.
526.
“[3H]Dihydrotetrabenazine Binding and [3H]Doapamine Uptake Inhibitory Activity of a Series
of Pyrrolidine Analogs at the Vesicular Monoamine Transporter-2”. By Justin Nickell, Ashish
Vartak, Peter A. Crooks, and Linda P. Dwoskin, Annual Meeting of the Society for
Neuroscience; Abstract 554.6/AA7, October, 2009, Chicago, IL.
527.
“Chemical Derivitives of the Anti-Leukemis Stem Cell Compound 4-Benzyl-2-memthyl1,2,4-thiadiazolidine-3,5-dione (TDZD-8) with Imptoved Activity.” By Monica L. Guzman,
Shama Nasim, Marlene Bayls, Cheryl Corbett, Peter A. Crooks and Craig T. Jordan,
Annual Meeting of the American Society of Hematology, Abstract 3764, New Orleans,
LA, December, 2009.
528.
“Chemical Genomics Screening Reveals that PI3K/mTOR Inhibition Enhances Activity of
the Anti-Leukemia Stem Cell Compound Parthenolide”. By Duane C. Hassane,
Siddhartha Sen, Cheryl A. Corbett, Peter A. Crooks, Monica L. Guzman and Craig T.
Jordan, Annual Meeting of the American Society of Hematology, Abstract 388, New
Orleans, LA, December, 2009.
529.
“Analysis of the Anti-Leukemia Mechanism of Parthenolide”. By Shanshan Pei, Monica
L. Guzman, Shama Nasam, Peter A. Crooks, and Craig T. Jordan, Annual Meeting of
the American Society of Hematology, Abstract 2734, New Orleans, LA, December,
2009.
131
530.
“In Vivo Pharmacokinetic Comparison of Transdermal S-(-)-Nornicotine (S-NN) and S-(-)Nicotine in Male Yucatan Minipigs”. By Zaineb Albayati, Buchi Nalluri, and Peter A.
Crooks, Twenty Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. M1107, p66, November, 2009, Los Angeles, CA.
531.
“Design and Synthesis od Selective 3-O-phosphate Analogs of Estradiol prodrugs for Bone
Targetting”. By Shama Nasim, William M. Pierce, Jr., Grant Taylor , and Peter A. Crooks,
Twenty Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. M1141, p67, November, 2009, Los Angeles, CA.
532.
“Synthesis and In Vivo Cytotoxicity of Substituted (Z)-2-Amino-5((1-benzyl-1H-Indol-3yl)methylene-1-methyl-1H-imidazol-4(5H)-ones”. By Narsimha Reddy Penthala, Thirupathi
Reddy Yerramreddy, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition
of the American Association of Pharmaceutical Scientists, Abstract No. M1155,
p68, November, 2009, Los Angeles, CA.
533.
“Stability of the Oral Formulation of the Novel Antitumor Agent LC-1 in Various Soft
Beverages”. By Sundar Neelakantan and Peter A. Crooks, Twenty Third Annual Meeting
and Exposition of the American Association of Pharmaceutical Scientists, Abstract No.
T2025, p80, November, 2009, Los Angeles, CA.
534.
“The Presence of the Environmental Pollutant, 2,2’-Dipyridyl is Directly Correlated to
Cotinine Levels in the Plasma of Smokers”. By Ahmad Malkawi, Jose De Leon, and Peter
A. Crooks, Twenty Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. T2071, p82, November, 2009, Los Angeles, CA.
535.
"A Novel Drug Hybrid of 3-O-Acetylmorphine and S-(-)-Nornicotine as a Potent Analgesic”.
By Ujjwal Chakraborty, Elzbieta Wala, Joseph Holtman, and Peter A. Crooks, Twenty
Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. T3193, p105, November, 2009, Los Angeles, CA.
536.
“Pharmacokinetic Profile of a Codeine-9-tetrahydrocannabinol Hybrid Drug for Pain
Management”. By Harpreet Dhooper, Zaineb Albayati, Jamie Horn, Joseph Holtman, and
Peter A. Crooks, Twenty Third Annual Meeting and Exposition of the American
Association of Pharmaceutical Scientists, Abstract No. T3194, p105, November, 2009,
Los Angeles, CA.
537.
“Development of a Stability-indicating HPLC method for the Analysis of S-(-)-Nornicotine
Difumarate”. Marhaba Hojahmat and Peter A. Crooks, Twenty Third Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. W4007,
P116, November, 2009, Los Angeles, CA.
538.
“Azaheterocyclic Modulators of the Vesicular Monoamine Transporter 2 (VMAT2)”. By
Ashish Vartak, Justin Nickell, Agripina G. Deaciuc, Jaturaporn Chagkutip, Linda P.
Dwoskin, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, Abstract No. W4186, p123, November,
2009, Los Angeles, CA.
539.
“Predictive Screening Model for Potential Vector-Mediated Transport of Cationic Substrates
at the Blood-Brain Choline Transporter”. By Cornelius J. Van der Schyf, Paul Lockman,
David Allen, Rajender Mittapalli, Vamshi Manda, Linda P. Dwoskin and Peter A. Crooks,
132
Twenty Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. W4191, p123, November, 2009, Los Angeles, CA.
540.
“Synthesis and Evaluation of Analogs of Lobelane Targetting the Vesicular Monoamine
Transporter-2 (VMAT2)”. By John Culver, Justin Nickell, Agripina G. Deaciuc, Linda P.
Dwoskin, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, Abstract No. W4197, p123, November,
2009, Los Angeles, CA.
541.
“Design and Synthesis of Novel Mono- and Duplex Pegylated Aminoparthenolide
Derivatives as Water soluble Antileukemic Agents”. By Nikhil Madadi, Thirupathi Reddy
Yerramreddy, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition of the
American Association of Pharmaceutical Scientists, Abstract No. W4199, p123, November,
2009, Los Angeles, CA.
542.
“Second Generation Analogs of 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8)
as Potent, Selective and Drugable Antileukemic Agents”. By Shama Nasim, Monica
Guzman, Craig Jordan, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition
of the American Association of Pharmaceutical Scientists, Abstract No. W4200, p123,
November, 2009, Los Angeles, CA.
543.
“Design, Synthesis and Antiproliferative Activity of Novel Resveratrol Analogs”. By Nikhil
Madadi, Thirupathi Reddy Yerramreddy, Narsimha Reddy Penthala, Srinivas Kodura,
Damodaran Chendil, and Peter A. Crooks, Twenty Third Annual Meeting and Exposition of
the American Association of Pharmaceutical Scientists, Abstract No. W5187, p1,
November, 2009, Los Angeles, CA.
“Synthesis and Antiproliferative Activity of Novel Substituted (Z)-5-(N-Benzyl-1H-indol-3yl)methyleneimidazolidin-2,4-diones”. By Thirupathi Reddy Yerramreddy, Narshima Reddy
Penthala, Srinivas Kodura, Damodaran Chendil, and Peter A. Crooks, Twenty Third Annual
Meeting and Exposition of the American Association of Pharmaceutical Scientists, Abstract
No. W5188, p140, November, 2009, Los Angeles, CA.
544.
545.
“Synthesis of Amino Acid Ester Prodrugs of 6-Naltrexone for Microneedle-enhanced
Transdermal Delivery”. By Josh Eldridge, Mikolaj Milewski, Audra Stinchcomb and Peter A.
Crooks, Twenty Third Annual Meeting and Exposition of the American Association of
Pharmaceutical Scientists, Abstract No. W5197, p141, November, 2009, Los Angeles, CA.
546.
“N-Substituted Methamphetamine Derivatives as Inhibitors of Dopamine Uptake at the
Vesicular Monoamine Transporter (VMAT2)”. By Guangrong Zheng, David Horton, Agripina
G. Deaciuc, Linda P. Dwoskin, and Peter A. Crooks, Twenty Third Annual Meeting and
Exposition of the American Association of Pharmaceutical Scientists, Abstract No. R6166,
P156, November, 2009, Los Angeles, CA.
547.
“Novel Small Molecule Alpha9 Alpha10 Nicotinic Receptor Antagonists for Pain
Management”. Joseph R. Holtman Jr., Linda P. Dwoskin, Elzbieta P. Wala, Peter A.
Crooks, and J. Michael McIntosh. 29th Annual Scientific Meeting of the American Pain
Society, May, 2010, Baltimore, MD.
548.
“Developing Radiation Sensitizers from Small Molecule Thermal Enhancers”. Konjeti R.
Sekhar, Y. Thirupathi Reddy, Vijayakumar N. Sonar, Peter A. Crooks, and Michael L.
Freeman, Annual Meeting of the Society of Thermal Medicine, April, 2010, Clearwater
Beach, FL.
133
Theses
"The Synthesis of Some 5-Aza- and 5, 7-Diazaindoles with Potential Oncolytic Activity". Peter A.
Crooks, M.Sc. Thesis, University of Manchester, UK, 1967.
"Alkaloids of Tabernaemontana Pachysiphon var. Cumminsii, and Cinchona Ledgeriana". Peter
A. Crooks, Ph.D. Thesis, University of Manchester, UK, 1970.
Book Reviews
"Introductory Medicinal Chemistry", J. B. Taylor, P. D. Kennewell, Halstead Press, New York,
1981. Reviewed by Peter A. Crooks, J. Medicin. Chem., 1983, 26, 458.
"Surfactant Systems - Their Chemistry, Pharmacy and Biology", David Attwood and Andrew T.
Florence, Chapman and Hall, New York, 1983. Reviewed by Peter A. Crooks,
J. Medicin. Chem., 1984, 27, 1754.
"Terpenoids and Steroids, Vol.12 Specialist Periodical Reports, Royal Society of Chemistry", J.
R. Hanson, Adlard and Sons, Ltd., 1983. Reviewed by Peter A. Crooks, J. Pharm. Sci., 1985,
74, 801-802.
"Biosynthesis, Vol. 7 Specialist Periodical Reports, Royal Society of Chemistry", R. B. Herbert
and T. J. Simpson, Adlard and Sons, Ltd., 1983. Reviewed by Peter A. Crooks, J. Pharm. Sci.,
1985, 74, 702.
"Environmental Chemistry, Vol. 3 Specialist Periodical Reports, Royal Society of Chemistry", H.
J. M. Bowen. Whitstable Litho Ltd., 1984. Reviewed by Peter A. Crooks, J. Pharm. Sci., 1985,
74, 906-907.
"Biological Methylation and Drug Design," Edit. Ronald T. Borchardt, C.R. Creveling, and P.M.
Ueland, Humana Press, Clifton, New Jersey, U.S.A., 1986. Reviewed by Peter A. Crooks, J.
Pharm. Sci., 1988, 77, 94.
134
Patent Activity
1.
"Co-Drugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, Canadian
Patent No. CA 2,182,228AA, February 17, 1994 (Licensed).
2.
"Co-Drugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, Australian
Patent No. AU 6,254,594A, August 15th, 1995 (Licensed).
3.
"Co-Drugs as a Method of Controlled Drug Delivery". Paul Ashton, Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs and Hong Guo, International
Patent, WO 95/20,567A1, August 3, 1995 (Licensed).
4.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Australian Patent No. AU
6,254,4594A1, August 15, 1995.
5.
"Co-Drugs as a Method of Controlled Drug Delivery". Paul Ashton, Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, European
Patent, No. 94-909643.2-2103, February 2, 1996 (Licensed).
6.
"Preparation of 2-azabicyclo[2.2.1]hept-5-ene and 2-azabicyclo[2.2.2]oct-5-ene;
Compounds of Use in Pharmaceutical Compositions for the Prevention and Treatment of
Central Nervous System Disorders". By Merouane Bencherif, William S. Caldwell, Gary
M. Dull, Patrick M. Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Niranjan M. Deo, and
Alain Ravard, International Patent, WO 96/36637A1, November 21, 1996 (Licensed).
7.
"Pharmaceutical Compositions for Prevention of Central Nervous System Disorders". By
Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S. Bhatti, Australian
Patent No. AU 4,645,596A1, July 24, 1996.
8.
"Codrugs as a Method of Controlled Delivery" By Paul Ashton, Peter A. Crooks, Robert
M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Guo Hong, European Patent EP
740,650A1, November 6, 1996.
9.
"Polynucleotide Analogs Based Upon Sulfonate and Sulfonamide Internucleoside
Linkages". John A. Secrist, John A. Montgomery and Peter A. Crooks, U.S. Patent No.
5, 561,225, October 1, 1996.
10.
"Use of L-Canavanine as a Chemotherapeutic Agent for the Treatment of Pancreatic
Cancer." By Peter A. Crooks and Gerald A. Rosenthal, U.S. Patent No. 5,552,440,
September 3, 1996.
11.
"Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous
System Diseases". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S.
Bhatti, International Patent, WO 96/20,929A1, July 11, 1996 (Licensed).
12.
"Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous
System Diseases". By Merouane Bencherif, William S. Caldwell, Gary M. Dull, Patrick M.
Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Naranjan M. Deo, Alain Ravard,
International Patent, WO 96/36,637A1, November 21, 1996 (Licensed).
135
13.
"Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous
System Disorders". By Merouane Bencherif, William S. Caldwell, Gary M. Dull, Patrick M.
Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Naranjan M. Deo, Alain Ravard,
Australian Patent No. AU 5383196, November 29, 1996 (Licensed).
14.
"Permeable, Non-Irritating Prodrugs of Non-Steroidal and Steroidal Agents". By Paul
Ashton, Thomas J. Smith, Peter G. Glavinos, John D. Conklin, Jr., Peter Anthony
Crooks, Robert Mack Riggs, Tadeusz Cynkowski and Grazyna Cynkowska, U.S. Patent
No. 5,681,964, October 28, 1997 (Licensed).
15.
"Nicotinic Receptor Antagonists in the Treatment of Neuropharmacological Disorders".
By Peter A. Crooks, Linda P. Dwoskin and Alain Ravard, U.S. Patent No. 5,691,365,
November 25, 1997 (Licensed).
16.
"Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System
Disorders". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S.
Bhatti, European Patent EP 801,646A1, October 22, 1997.
17.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, and Hong Guo, Japanese
Patent No. JP 9,509,151TZ, September 16, 1997 (Licensed).
18.
"Compounds Which are Useful for Prevention and Treatment of Central Nervous System
Disorders". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
Niranjan M. Deo, Alain Ravard, U.S. Patent No. 5,616,707, April 1, 1997 (Licensed).
19.
"Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System
Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
European Patent No. EP0801646A1, October 22, 1997 (Licensed).
20.
"Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System
Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
Niranjan M. Deo and Alain Ravard, U.S. Patent No. 5,726,316, March 10, 1998
(Licensed).
21.
"3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders". By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M.
Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M.
Dull, Canadian Patent No. CA 2,294,990, April 22, 1998.
22.
"Lobeline Compounds as a Treatment for Psycho Stimulant Abuse and Withdrawal, and
for Eating Disorders". By Peter A. Crooks and Linda P. Dwoskin, U.S. Patent No.
5,830,904, November 3, 1998. (Licensed).
23.
"Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System
Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
European Patent No. EP0801646A4, March 25th, 1998 (Licensed).
24.
"Nornicotine Enantiomers for Use as a Treatment for Dopamine-Related Conditions and
Disease States". By Peter A. Crooks, Linda P. Dwoskin and Michael T. Bardo, U.S.
Patent No. 5,776,957, July 8, 1998.
136
25.
"Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System
Disorders". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S.
Bhatti, European Patent EP 801,646A4, March 25, 1998.
26.
"Compounds which are Useful for Prevention and Treatment of Central Nervous System
Disorders". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
Niranjan M. Deo, Alain Ravard, Japanese Patent No. JP 11501294T, February 2, 1999
(Licensed).
27.
"3-Pyridyl-1-azabicycloalkane Derivatives for Prevention and Treatment of CNS
Disorders." By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks,
Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, International
Patent, WO 99/00,385A1, January 7th, 1999 (licensed).
28.
"Azatricyclic Compounds." By Peter A. Crooks and Niranjan M. Deo, International Patent,
WO 99/51,601A1, October 14th, 1999 (licensed).
29.
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner,
Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell,
and Haeil Park, Canadian Patent No. CA 2,334,923, June 3, 1999.
30.
"Azatricyclo[3.3.1.1]Decane Derivatives and Pharmaceutical Compositions Containing
Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, International Patent, WO
99/51,602A1, October 14th, 1999 (licensed).
31.
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists". By
William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil
Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif,
International Patent, WO 99/65,876A1, December 23rd, 1999.
32.
"Pharmaceutical Compositions and Methods for Effecting Dopamine Release". By
William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M.
Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, Canadian Patent
Application, CA 2,294,990, December 20, 1999.
33.
"Canavanine Analogs and Their Use as Chemotherapeutic Agents". By Peter A. Crooks
and Gerald A. Rosenthal, U.S. Patent No. 5,859,295, January 12, 1999.
34.
"Pharmaceutical Compositions and Methods for Use". By Peter A. Crooks, Haeil Park,
Gary M. Dull, Patrick M. Lippiello, Merouane Bencherif, Balwinder S. Bhatti, and William
S. Caldwell, Canadian Patent No. CA 2,317,567, October 10th, 1999.
35.
"Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and
their Use as Inhibitors of Nicotinic Cholinergic Receptors". By Gary M. Dull, Jeffrey
D. Schmitt, and Peter A. Crooks, Canadian Patent No. CA 2,317,025, August 31,
1999.
36.
"Azatricyclic Compounds". By Niranjan M. Deo, and Peter A. Crooks, Canadian Patent
No. CA 2,317,570, February 26, 1999.
37.
"Azatricyclo[3.3.1.1]Decane Derivatives and Pharmaceutical Compositions Containing
Them." By Haeil Park, Gary M. Dull, William S. Caldwell, Balwinder S. Bhatti,
137
Patrick M. Lippiello, Peter A. Crooks,
Patent No. CA 2,317,567, March 3, 1999.
and
Merouane
Bencherif,
Canadian
38.
"Pharmaceutical Compositions and Methods for Use". By Peter A. Crooks and Niranjan
M. Deo, U.S. Patent No. 5,986,100, November 16, 1999 (Licensed).
39.
"Azatricyclo[3.3.1.1]decane
Derivatives
and
Pharmaceutical
Compositions
Containing Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, German
Patent No. DE 69,907,894D, October 14th, 1999.
40.
"Azatricyclo[3.3.1.1]decane
Derivatives
and
Pharmaceutical
Compositions
Containing Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Danish
Patent No. DK 1,068,208T, October 14th, 1999.
41.
"3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders". By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks,
Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, Australian
Patent No. AU 7,149,798A1, January 19, 1999.
42.
"Azatricyclic Compounds". By Peter A. Crooks and Niranjan M. Deo, Australian Patent
No. AU 2,794,899A1, October 25th, 1999.
43.
"Means to Achieve Sustained Release of Synergistic Drugs By Conjugation". Paul
Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs
and Hong Guo, U.S. Patent No. 6,051,576, April 18th, 2000 (Licensed).
44.
"Use of Lobeline Compounds in the Treatment for Central Nervous System Diseases
and Pathologies." By Peter A. Crooks and Linda P. Dwoskin, U.S. Patent No. 6,087,376,
July 11, 2000.
45.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Guo Hong, European
Patent EP 740,650A4, April 19, 2000.
46.
"3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders". William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks,
Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, European
Patent EP 994,875A1, April 26, 2000.
47.
"Certain 1-Aza-tricyclo[3.3.1-13,7]decane Compounds". By Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, U.S. Patent, 6,057,446, May
2, 2000.
48.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A. Crooks,
Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Australian Patent No. AU
705,226B2, May 20, 2000.
49.
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B.
138
Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and
Merouane Bencherif, Australian Patent No. AU 4,230,799, January 5, 2000.
50.
"Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and
their Use as Inhibitors of Nicotinic Cholinergic Receptors". By Jeffrey D. Schmitt,
Peter A. Crooks, and Gary M. Dull, European Patent No. EP 1,053,236, June 15th,
2000.
51.
"Use of Bacteriophage Peptides to Manufacture Markers for Rapid Assays, and for
Specific Cell Delivery of Antibiotics." By Clair L. Hicks and Peter A. Crooks,
Submitted to the Office of Intellectual Properties, University of Kentucky (UKRF
Case No. 999), September, 20th, 2000, filed as a US provisional patent.
52.
"Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and
their Use as Inhibitors of Nicotinic Cholinergic Receptors". By Jeffrey D. Schmitt,
Peter A. Crooks, and Gary M. Dull, Australian Patent No. AU 5,699,399, June
26th, 2000.
53.
"Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with
Oxaalkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna
Cynkowska, Hong Guo, and Paul Ashton, International Patent No. WO 067,801A2,
November 16th, 2000 (Licensed).
54.
"Thermal Vaporizing Device for Drug Delivery". By Peter A. Crooks, S. George Kottayil,
and David Riggs, Provisional US Patent Application No. 60/243,404, October 27, 2000.
55.
"Compounds Useful for the Treatment of CNS Pathologies." By Peter A. Crooks, Linda
P. Dwoskin, Rui Xu, and Vladimir Grinevich, (Docket No. 50229-193), U.S. Patent
Application No. 60/228,766, August 30th, 2000.
56.
"Pyridyl-Bridgehead Derivatives and their Analogues, Pharmaceutical Compositions and
Their Use as Inhibitors of Nicotinic Cholinergic Receptors." By Jeffrey D. Schmitt, Peter
A. Crooks, and Gary M. Dull, International Patent No. WO 034,276A1, June 15, 2000.
57.
"Azatricyclo(3.3.1.1)decane Derivatives and Pharmaceutical Compositions Containing
Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Australian Patent No.
AU 2,892,999A1, May 2, 2000.
58.
"Derivados de Azatriciclo(3.3.1.1)decano e Composicoes Farmaceuticas ContendoOs." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Brazilian Patent No.
BR 9,907,172A, October 10, 2000.
59.
"Derivados de Cabeca de Ponte de Piridila e Seus Analogos, Composicoes
Farmaceuticas e Seus Empregos Como Inibidores de Receptores Colinergicos
Nicotinicos." By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, Brazilian
Patent No. BR 9,907,169, October 17, 2000.
60.
"Pharmaceutical Compositions and Methods for Use". By Niranjan M. Deo and Peter
A. Crooks, Canadian Patent No. CA 2,317,570, June 29th, 2000.
61.
"Compostos Azatriciclicos". By Peter A. Crooks and Niranjan M. Deo, Brazilian Patent
139
No. BR 9907191A, December 26th, 2000.
62.
"Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with
Oxaalkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Hong Guo, and Paul Ashton, Australian Patent No. AU 4703700, November 16th, 2000
(Licensed).
63. “3-Pyridyl-1-aza-bicyclo-alkanderative zur Behandlung von ZNS-Erkrankungen”. By William
S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello,
Balwinder S. Bhatti, Niranjan M. Deo, Alain Ravard, European Patent No. EP 0994875,
May 31st, 2000.
64.
"Agmatine and Agmatine Analogs In the Treatment of Epilepsy, Seizure, and
Electroconvulsive Disorders". By Peter A. Crooks, Aimee K. Bence, and David R.
Worthen, Australian Patent No. AU 6,842201, June 15th, 2000.
65.
"Use of the Naturally Occurring Quinones, Thymoquinone and Dithymoquinone, as
Antineoplastic and Cytotoxic Agents". Peter A. Crooks, David R. Worthen, and Omar
Ghosheh. U.S. Patent No. 6,218,434, April 17, 2001.
66.
"Boron-Containing Nicotine Analogs for Use in the Treatment of CNS Pathologies." By
Peter A. Crooks, Linda P. Dwoskin, Rui Xu, Vladimir Grinevich, and Roger L.
Papke, (Docket No. 50229-249), U.S. Patent Application No. 60/261,822, May,
2001.
67.
"Azatricyclic Compounds". By Peter A. Crooks and Niranjan M. Deo, European Patent
No. EP 1,066,287A1, January 10, 2001.
68.
"Azatricyclo(3.3.1.1)decane Derivatives and Pharmaceutical Compositions Containing
Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, European Patent No. EP
1,068,208A1, January 17, 2001.
69.
"Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies."
By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, International Patent No.
WO 01/08678A1, February 8, 2001.
70.
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B.
Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and
Merouane Bencherif, European Patent No. EP 1,086,082A1, March 28, 2001.
71.
"Pharmaceutical Compositions and Methods for Use". By Peter A. Crooks and
Niranjan M. Deo, U.S. Patent No. 6,211,372, April 3, 2001.
72.
"Aminas Olefinicas Substituidas com Arila e o seu uso como Agonistas de Receptores
Colinergicos." By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
Srishalikumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks,
Patrick M. Lippiello, and Merouane Bencherif, Brazilian Patent No. BR 9,911,325,
April 3, 2001.
140
73.
"Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids." By Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, European
Patent No. EP 928,867, December 12, 2001.
74.
"Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with
Oxaalkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Hong Guo, and Paul Ashton, International Patent No. WO 0067801 A3,
August 2nd, 2001 (Licensed).
75.
"Agmatine and Agmatine Analogs In the Treatment of Epilepsy, Seizure, and
Electroconvulsive Disorders". By Peter A. Crooks, Aimee K. Bence, and David R.
Worthen, International Patent No. WO 01/95897, December 20, 2001.
76.
"Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the Treatment
of CNS Pathologies." By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Joshua
Ayers, Provisional U.S. Patent No. US 60/342,120, filed December 26th, 2001.
77.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents
with Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Paul Ashton, and Hong Guo, Canadian Patent No. CA 2,368,831, November 5th, 2001.
78.
“Aza-Aminotetralin Compounds for Use in the Treatment of CNS Pathologies.” By
Peter A. Crooks, Linda P. Dwoskin, and Rui Xu, submitted to the Office of
Intellectual Properties, University of Kentucky, (UK Case No. 1069, Docket No. 50229281). July, 8, 2001,
79.
“Analgesics and Methods of Use”. By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, U.S. Patent Application No. 60/315,530,
August 29th, 2001.
80.
“bis-Pyridino Containing Compounds for Use in the Treatment of CNS Pathologies.”
By Peter A. Crooks, Linda P. Dwoskin, and Joshua Ayers, submitted to the Office
of Intellectual Properties, University of Kentucky, (UK Case No. 1101). November 12th,
2001.
81.
“Thermal Vaporizing Device for Drug Delivery”. By Peter A. Crooks, George S. Kottayil,
Ram Murty, and David Riggs, Australian Patent Application No. AU 2002246500,
October 1st, 2001.
82.
“Azatricyclo[3.3.1.1]decanderivate
und
diese
Enthaltende
Pharmazeutische
Zubereitungen“. By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil
Park, Balwinder S. Bhatti, William S. Caldwell, Gary M. Dull, European Patent No. EP
1068208, February 2nd, 2001.
83.
"Bridged Nicotine Compounds for Use In the Treatment of CNS Pathologies". By
Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir Grinevich, International
Patent No. WO 02/17922, March 7, 2002.
84.
"Agmatine and Agmatine Derivatives for Use in the Treatment of Epilepsy, Seizure and
Electroconvulsive Disorders". By Peter A. Crooks, Aimee K. Bence, and David R.
Worthen, U.S. Patent Application No. 09/881,215, filed June 15, 2000, Publication No.
US 2002/0065323 A1, Pub. Date May 30, 2002.
141
85.
"Compounds for Use in the Treatment of Epilepsy, Seizure and Electroconvulsive
Disorders.” By Peter A. Crooks, Aimee K. Bence, and David R. Worthen,
Provisional U.S. Patent No. US 60/348,366, filed January 16th, 2002
86.
"Cis-2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor
Mediated Neurotransmitter Release and Neurotransmitter Uptake and Storage".
By Peter A. Crooks, Guangrong Zheng, Dennis K. Miller, Seth Norrholm, Vladimir
P. Grinevich, and Linda P. Dwoskin, U.S. Patent Application No. US 10/163,633,
June 7th, 2002.
87.
“Morphine-6-O-sulfate Analogues and Their Use for the Treatment of Pain”. By Peter
A. Crooks, Abdulghani A. Houdi, Santosh G. Kottayil, and D. Allan Butterfield, U.S.
Patent No. 6,403,602, June 11th, 2002.
88.
“Pharmaceutical Compositions and Methods for Use”. By Peter A. Crooks, Haeil Park,
Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, U.S. Patent No. 6,417, 359,
July 9th, 2002.
89.
“Boron-Containing Nicotine Analogs for Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Vladimir P. Grinevich, and Rui Xu, International
Patent No. WO 02/057275, July 25th, 2002.
90.
"3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders". By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M.
Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M.
Dull, Japanese Patent No. JP 2002511090, April 9th, 2002.
91.
“Thermal Vaporizing Device for Drug Delivery”. By S. George Kottayil, Peter A. Crooks,
David Riggs, and Ram Murty, International Patent No. WO 02/056932, July 25th, 2002.
92.
“Pharmaceutical Compositions and Methods for Use”. By Jeffrey D. Schmitt, Peter A.
Crooks, and Gary M. Dull, U.S. Patent No. 6,432,975, August 13th, 2002.
93.
“Analgesics and Methods of Use”. By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent Application,
PCT Serial No. PCT/US/27936, filed August 29th, 2002.
94.
“Pharmaceutical Compositions and Methods for Use”. By Jeffrey D. Schmitt, Peter
Crooks, and Gary M. Dull, Japanese Patent No. JP 2002531564T T, September 24th,
2002.
95.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents
with Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Hong Guo, and Paul Ashton, European Patent No. EP 1,233,789A August 28th, 2002.
96.
“Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies."
By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, U.S. Patent No. 6,455,543,
September 24th, 2002.
97.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M.
Wagner, and Peter A. Crooks, U.S. Patent Application No. 09/973,411, filed October 9,
2001, Publication No. US 2002/0052497 A1, Publication Date, May 2nd, 2002.
142
98.
"Thermal Vaporizing Device for Drug Delivery". By Peter A. Crooks, S. George Kottayil,
and David Riggs, U.S. Patent Application No. 09/984,294, filed October 29, 2001,
Publication No. US 2002/0117175 A1, Publication Date August 29th, 2002.
99.
“Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, U.S.
Patent Application No. 09/941,926, filed August 30, 2001, Publication no. US
2002/0099069 A1, Publication Date July 25th, 2002.
100.
“Lobeline and Other Gag Reflex-Inducing Bitter Alkaloids in Combination with
Opioids in Extended Release Formulations to Deter Targeted Chewing by
Recreational or Addicted Drug Abusers”. By Richard D. Smith-Carliss and Peter
A. Crooks, to be filed as a U.S. Provisional Patent, October, 2002.
101.
“Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies”. By Peter A.
Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, Australian
Patent No. AU 8,687501, July 25th, 2002.
102.
"Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids." By Peter A. Crooks,
Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, European
Patent No. EP 1,233,789, August 28th, 2002.
103.
“Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and
Pathologies." By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones,
Australian Patent No. AU 6,386700, September 24th, 2002.
104
“Analgesic Uses of Norketamine and Ketamine/Norketamine”. By Peter A. Crooks, and
Miguel Rivera, U.S. Provisional Application No. 60/426,793, November 18th, 2002.
105.
"Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the
treatment of CNS Pathologies." By Peter A. Crooks, Linda P. Dwoskin, Rui Xu,
and Joshua Ayers, U.S. Patent Application No. 10/328,192, filed December
26th, 2002.
106.
“Pharmaceutical Compositions and Methods for Use.” By Peter A. Crooks and
Naranjan M. Deo, Japanese Patent No. JP 2002510689T, April 9th, 2002.
107.
"Azatricyclo[3.3.1.1]decane
Derivatives
and
Pharmaceutical
Compositions
Containing Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Japanese
Patent No. JP 2002510690T, April 9th, 2002.
108.
“Analgetic Pyrroline Derivatives”. By Frank S. Caruso, Peter A. Crooks, Kenneth J.
Kellar, Richard Smith-Carliss, and Yingxian Xiao, Australian Patent Application No. AU
2002326806, August 29th, 2002.
109.
“Boron-containing Nicotine Analogs for use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Vladimir P. Grinevich, and Rui Xu, Australian Patent
Application No. AU 2002241900, January 17th, 2002.
110.
“Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and
143
Pathologies." By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones,
U.S. Patent Application, No. 10/231,156, August 30th, 2002.
111
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner,
Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell,
and Haeil Park, Japanese Patent No. JP 2002518373T T, June 25th, 2002.
112.
“Analgetic Pyrroline Derivatives”. By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, European Patent Application No. EP
02,761,550.9-2123, filed August 29th, 2002.
113.
“Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies.” By
Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, U.S.
Patent No. 6,503,922, January 7th, 2003.
114.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents
with Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Hong Guo, and Paul Ashton, Japanese Patent No. JP 2003513884T T, April 15th, 2003.
115.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane
Bencherif, U.S. Patent Application No. 10,263,083
filed October 2nd, 2002.
Publication No. US 2003/0125345 A1, Publication Date July 3rd, 2003.
116.
“Pharmaceutical Compositions and Methods for Effecting Dopamine Release”. By
William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, and
Patrick M. Lippiello, U.S. Patent No. 6,525,065, February 25th, 2003.
117.
“Pharmaceutical Compositions and Methods for Use.” By Jeffrey D. Schmitt, Peter
A. Crooks, and Gary M. Dull, U.S. Patent Application, Publication
No. US
2003/0045523 A1, Publication Date March 6th, 2003.
118.
“Analgesics and Methods of Use.” By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent No. WO
03018004 A2, Publication date March 6th, 2003.
119.
“Opiate Agonist and Antagonist Duplex Prodrugs for Transdermal Delivery”. By
Peter A. Crooks, Mohamed O. Hamad, and Audra L. Stinchcomb, UK Disclosure
No. 1183, Docket No. 50229-337, filed as a U.S. Provisional Patent Application,
No. 60/489,183, July 23rd, 2003.
120.
"Azatricyclo[3.3.1.1]decane
Derivatives
and
Pharmaceutical
Compositions
Containing Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, European
Patent No. EP 1068208 B1, May 14th, 2003.
121.
“Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and
Pathologies." By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones,
U.S. Patent Application, Publication No. US 2003/0100547 A1, Publication date
May 29th, 2003.
144
122.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents.” By
Peter A. Crooks, Xiachem Wei and Craig Jordan, filed as a Provisional U.S.
Patent Application No. 60/486,171, July11th, 2003.
123.
"Azatricyclo[3.3.1.1]decanderivate
und
Diese
Enthaltende
Pharmazeutische
Zubereitungen" By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Austrian
Patent No. AT 24,0331T, May 15th, 2003.
124.
"Thermal Vaporizing Device for Drug Delivery". By Peter A. Crooks, S. George
Kottayil, Ram Murty and David Riggs, International Patent Application No. WO
02056932 A3, August 7th, 2003.
125.
"Thermal Vaporizing Device for Drug Delivery". By Peter A. Crooks, S. George
Kottayil, Ram Murty and David Riggs, International Patent Application No. WO
02056932 A9, May 1st, 2003.
126.
“Pharmaceutical Compositions for Treating and/or Preventing CNS Disorders.” By
Peter A. Crooks, Gary M. Dull, William S. Caldwell, Balwinder S. Bhatti, Naranjan
M. Deo, and Alain Ravard, U.S. Patent No. 6,624,173 B1, September 23rd, 2003.
127.
“Azatrizyclische Verbindungen.” By Niranjan M. Deo
Austrian Patent No. AT 248,839T, September 15th, 2003.
128.
"Azatricyclic Compounds". By Peter A. Crooks and Niranjan M. Deo, European Patent
No. EP 1066287 B1, September 3rd, 2003.
129.
"Compounds of Use in the Treatment of Epilepsy, Seizure and Electroconvulsive
Disorders.” By Peter A. Crooks, Aimee K. Bence, and David R. Worthen,
U.S. Patent
Application No. US 2003/0,186,942, publication date October 2nd,
2003.
130.
“Pharmaceutical Compositions and Methods for Use.” By Peter A. Crooks and
Naranjan M. Deo, German Patent No. DE 6,991,099D, October 10th, 2003.
131.
"Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the
Treatment of CNS Pathologies." By Peter A. Crooks, Linda P. Dwoskin, Rui Xu,
and Joshua Ayers, U.S. Patent Application No. US 2003/0225142A1, December
4th, 2003.
132.
“Analgetic Pyrroline Derivatives”. By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, Canadian Patent Application
No. CA 2,458,015, filed March 3rd, 2003.
133.
“bis-Pyridino-containing Compounds for Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Joshua T. Ayers, and Vladimir Grinevich, Provisional
U.S. Patent Application No. 60/533,213, Decmber 31st, 2003.
134.
“Derivados do Azatriciclo 3.3.1.1 Decano e Composicoes Farmaceuticas Contendo
os Mesmos.” By Peter A. Crooks, Haeil Park, and Gary M. Dull, Portuguese
Patent No. PT 1,068,208T, September 30th, 2003.
and
Peter
A.
Crooks,
145
135.
“Analgesics and Methods of Use.” By Richard Smith-Carliss, Frank S. Caruso, Peter
A. Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent No. WO
03018004 A3, May 22nd, 2003.
136.
“Aryl Substituted Olefinic Amines and their Uses as Cholinergic Receptor Antagonists”.
By Merouane Bencherif, Balwinder S. Bhatti, William S. Caldwell, Peter A. Crooks,
Patrick Lipiello, Gary M. Dull, Jared M. Wagner, Srishailkumar B. Hadimani, and Haeil
Park, Australian Patent Application No. AU 2003236404, August 21st, 2003.
137.
“Pharmaceutical Compositions and Methods for Use.” By Peter A. Crooks and Naranjan
M. Deo, Danish Patent No. DK 1,066,287T, January 19th, 2004.
138.
“2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor
Mediated Neurotransmitter Release, Uptake and Storage.” By Peter A. Crooks, Linda P.
Dwoskin, Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong
Zheng, U.S. Patent Application No. US 2004/0019081 A1, January 29th, 2004.
139.
“2,6-disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor Mediated
Neurotransmitter Release, Uptake and Storage.” By Peter A. Crooks, Linda P. Dwoskin,
Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong Zheng, U.S.
Patent No. US 6,703,406, March 9th, 2004.
140.
“Bioactive Peptide-based Probes.” By Clair L. Hicks and Peter A. Crooks (Docket No.
434-286, UKRF Disclosure No. 999), U.S. Patent Application No. 10/795,174, filed March
5th, 2004.
141.
“Disubstituted Piperidine and Piperazine Compounds”. By Peter A. Crooks, Linda P.
Dwoskin, Guangrong Zheng, Marlon Jones, Dennis K. Miller, Seth Norrholm, and Sairam
Krishnamurthy (Docket No. 64684-024), U.S. Patent Application, filed April 1st, 2004.
142.
“2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor
Mediated Neurotransmitter Release, Uptake and Storage.” By Peter A. Crooks, Linda P.
Dwoskin, Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong
Zheng, U.S. Patent Application No. US 2004/0019081, January 29th, 2004.
143.
“3-Pyridyl-1-Azabicycloalkan-Derivate Zur Behandlung Von ZNS-Erkrankungen.” By
Niranjan M. Deo, Alain Ravard, William S. Caldwell, Merouane Bencherif, Gary M. Dull,
Peter A. Crooks, Patrick M. Lippiello, and Balwinder S. Bhatti, Austrian Patent No. AT
261443T, March 15th, 2004.
144.
“Azatricyclo[3.3.1.1]decane
Derivatives
and
Pharmaceutical
Compositions
Containing Them." By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks,
Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Spanish
Patent No. ES 2,199,561T, February 16th, 2004.
145.
“Compostos Azatricilicos.” By Peter A. Crooks and Niranjan M. Deo, Portuguese
Patent No. PT 1,066,287T, January 30th, 2004.
146.
“Kombinierte Wirkstoffe als Methode Zur Gezieten Wirkstoffe-Freisetzung”. By Paul
Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna
Cynkowska, Austrian Patent No. AT 267,798T, June 15th, 2004.
146
147.
“Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter A.
Crooks and Miguel Rivera, International Patent No. WO 2004/045601, June 3rd,
2004.
148.
“Pharmaceutical Compounds and Methods for Use”. By Peter A. Crooks and
Naranjan M. Deo, Spanish Patent No. ES 2,205,778T, May 1st, 2004.
149.
“Method for Treatment of Cancer”. By Peter A. Crooks and Robert Alonso, U.S.
Patent Application (Docket No. YAUP-3920), filed July 8th, 2004.
150.
“3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders”. By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M.
Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M.
Dull, Danish Patent No. DK 994,875, June 26th, 2004.
151.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with
Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong
Guo, and Paul Ashton, U.S. Patent No. US 6,765,019 July 20th, 2004.
152.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A.
Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, German
Patent No. DE 69,433,818D, July 1st, 2004.
153.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A.
Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, European
Patent No. EP 0,740,650 B1, May 26th, 2004.
154.
"Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner,
Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell,
and Haeil Park, European Patent No. EP 1,086,082 B1, August 18th, 2004.
155.
“Pharmaceutical Compounds and Methods for Use”. By Peter A. Crooks and Naranjan M.
Deo, German Patent No. DE 69,910,993T, July 22nd, 2004.
156.
“Analgetic Pyrroline Derivatives”. By Richard Smith-Carliss, Frank S. Caruso, Peter A.
Crooks, Kenneth J. Keller, and Yingxian Xiao, European Patent Application No. EP
1420781 A2, May 26th, 2004.
157.
“3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders”. By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M.
Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M.
Dull, German Patent No. DE 69,822,300D, May 15th, 2004.
158.
“3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders”. By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M.
Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M.
Dull, European Patent No. EP 0994,875 B1, March 10th, 2004.
159.
“Derivados De 3-Piridil-1-aza-biciclo-alcano Para A Prevencao E Tratamento De
Desordens Do SNC”. By By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo,
Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif,
and Gary M. Dull, Portuguese Patent No. PT 994875T, June 30th, 2004.
147
160.
“Arylsubstituierte Olefinische Amine und Ihre Verwendung als Cholinergische
Rezeptoragonisten” By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks,
Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti,
William S. Caldwell, and Haeil Park, Austrian Patent No. AT 273,956T,
September 15th, 2004.
161.
“Co-Farmacos Como um Metodo de Administracao Controlada de Farmacos”. By
Peter A. Crooks, Paul Ashton, Robert M. Riggs, Tadeusz Cynkowski, Grazyna
Cynkowska, Portuguese Patent No. PT 740650T, October 10th, 2004.
162.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents.” By
Peter A. Crooks, Xiachem Wei and Craig Jordan, U.S. Patent Application
No. 10/888,274, July 9th, 2004.
163.
"Codrugs as a Method of Controlled Drug Delivery". By Paul Ashton, Peter A.
Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Danish
Patent No. DK 740650T, September 27th, 2004.
164.
“Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter A.
Crooks and Miguel Rivera, Australian Patent No. AU 2003,291,037, June 15th,
2004.
165.
“Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter A.
Crooks and Miguel Rivera, Canadian Patent No. CA 2,506,615, June 3rd, 2004.
166.
“Azatricyclo[3.3.1.1]decanderivate und diese Enthaltende Pharmazeutische
Zubereitungen“. By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil
Park, Balwinder S. Bhatti, William S. Caldwell, Gary M. Dull, German Patent No. DE
69907894T2, November 3rd, 2004.
167.
“3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS
Disorders”. By Gary M. Dull, Patrick M. Lippiello, Merouane Bencherif, Balwinder
S. Bhatti, William S. Caldwell, and Peter A. Crooks, Spanish Patent No. ES
2,214,707T, September 16th, 2004.
168.
“2,6-Disubstituted Piperidines and Piperazine Compounds”. By Peter A. Crooks,
Linda P. Dwoskin, Marlon D. Jones, Dennis K. Miller, Seth D. Norholm,
Guangrong Zheng, and Sairam Krishamurthy, U.S. Patent Application No.
10/813,647, March 31st, 2004.
169.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents
with Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska,
Hong Guo, and Paul Ashton, U.S. Patent No. US 2004/0214784, October 28th, 2004.
170.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. US 2004/0214835,
October 28th, 2004.
171.
“Arylsubstituerede Olefiiske Aminer og deres Anvendelse som Cholinerge
Receptoragonister”. By Patrick M. Lippiello, Merouane Bencherif, Peter A.
Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S.
Bhatti, William S. Caldwell, and Haeil Park, Danish Patent No. DK 1,086,082T,
November 22nd, 2004.
148
172.
“Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter
A. Crooks and Miguel Rivera, U.S. Patent No. US2004/0248964 A1, December
9th, 2004.
173.
“Compounds of Use in the Treatment of Epilepsy, Seizer, and Electroconvulsive
Disorders”. By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S.
Patent No. US2004/0266737, December 30th, 2004.
174.
“2, 6-Disubstituted Piperidines and Piperazine Compounds”. By Peter A. Crooks,
Linda P. Dwoskin, Guangrong Zheng, Dennis K. Miller, Seth D. Norholm,
Krishnan
Sairam, and Marlon D. Jones, U.S. Patent No. US2004/0266824, December 30th, 2004.
175.
“bis-Pyridino-containing Compounds for Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Joshua T. Ayers, and Vladimir Grinevich, U.S. Patent
Application No. 11/027, 675, January 3rd, 2005.
176.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter
A. Crooks, Craig T. Jordan, and Xiaochen Wei, International Patent
WO2005007103, January 27th, 2005.
No.
177.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter
A. Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent Application No. US
2005/0032886, February 10th, 2005.
178.
“Novel Oral Bioavailable prodrugs”. By Peter A. Crooks, Mohamed O. Hamad, and
Audra L. Stinchcomb, International Patent No. WO 2005/009377 A2, February 3rd,
2005.
179.
“2,6-Disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and
Pathologies”. By Peter A. Crooks, Linda P. Dwoskin, and Marlon D. Jones, U.S.
European Patent No. EP1513513, March 16th, 2005.
180.
“Scopolamine Sublingual Spray for the Treatment of Motion Sickness”. By Peter A.
Crooks, Abeer M. Al Ghananeem, and Ahmad Malkawi, U.S. Patent Application, No.
US60/656,359 filed February 25th, 2005.
181.
“Lofexidine Enantiomers for Use as a Treatment for CNS Diseases and
Pathologies”. By George A. Digenis, Peter A. Crooks, and Abeer M. Al
Ghananeem, U.S. Patent Application No. US60/661,525, filed March 14th, 2005.
182.
“Sublingual Oxycodone for Acute Pain Management”. By Peter A. Crooks, Abeer M. Al
Ghananeem, and Ahmad Malkawi, U.S. Patent Application No. 60/666,060, filed March
29st, 2005.
183.
“Use of 3-Aryl/Heteroaryl-2-thiophene-3-yl-acrylonitriles as Anticancer Agents”. By
Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Propertied Committee, Case No. 1338, March 22nd,
2005.
184.
“Use
of
Substituted
N’-(1H-Indol-3-ylmethylene)-N-alkyl-N-phenylhydrazines
as
Anticancer Agents”. By Peter A. Crooks and Vijayakumar Sonar, U.S. Patent
149
Application, submitted to the University
Committee, Case No. 1339, March 23rd, 2005.
of
Kentucky
Intellectual
Properties
185.
“Use of N’-Indol-3-ylmethylene)- and N-alkyl-N’-benzo[b]thiophen-3-ylmethylene-Nphenylhydrazines as Antitubercular Agents”. By Peter A. Crooks and Vijayakumar
Sonar, U.S. Patent Application, submitted to the University of Kentucky
Intellectual
Properties Committee, Case No. 1342, March 25th, 2005.
186.
“Use of 3-(2-Nitrovinyl)- and 3-(2-Nitropropenyl)indoles as Anticancer Agents”. By
Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Properties Committee, March 29th, 2005.
187.
“Codrugs as a Method of Controlled Drug Delivery”. By Paul Ashton, Peter A.
Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Danish
Patent No. DK 740650T, September 27th, 2004. Spanish Patent No. ES
2,222,455T, February 1st, 2005.
188.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. US 2005/0131034,
June 16th, 2005.
189.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S.
Patent No. US 2005/0148611, July 7th, 2005.
190.
“Novel Oral Bioavailable Prodrugs”. By Peter A. Crooks, Mohamed O. Hamad, and
Audra L. Stinchcomb, U.S. Patent No. US 2005/0154002, July 14th, 2005.
191.
“bis-Pyridino-containing Compounds for Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Joshua T. Ayers, Vladimir Grinevich, and Sangeetha
P. Sumithran, International Patent No. WO 2005/066129 A2, July 27th, 2005.
192.
“Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter
A. Crooks and Miguel Rivera, European Patent No. EP 1567145, August 31st,
2005.
193.
“Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and
Withdrawal, Eating Disorders, and Central Nervous System Diseases and
Pathologies." By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones,
U.S. Patent No. US 6,943,177, September 13th, 2005.
194. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Use Thereof”. Peter
A. Crooks, and Robert Alonso, U.S. Patent Application, Docket No. YAUPON-4248US1,
December, 2005.
195.
“Use of Parthenolide Derivatives as AntiLeukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, Continuation in Part of U.S. Patent
Application No. US 2005/0032886 (February 10th, 2005), Docket No. 75812.010200,
Serial No. 11/31,315, January 7th, 2005.
196.
”R(+)- and S(-)-Nornicotine for the Treatment of Pain”. By Joseph R. Holtman,
Peter A. Crooks, and Linda P. Dwoskin, U.S. Patent Application, submitted to the
150
University of Kentucky Intellectual Properties Committee, Case No. 1377. November
17th, 2005.
197.
“Synergistic Enhancement of Opiod Analgesia by Combination with S(-)-Nornicotine
or R(+)-Nornicotine”. By Joseph R. Holtman, and Peter A. Crooks, U.S. Patent
Application, submitted to the University of Kentucky Intellectual Properties
Committee, Case No. 1379. November 17th, 2005.
198.
“Synergistic Enhancement of Opioid Analgesia and Attenuation of Opiod Tolerance
and dependence by Combination with Racemic, S-(-)- and R(+)-Norketamine”. By
Joseph R. Holtman, and Peter A. Crooks, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Properties Committee, Case No. 1380. November
17th, 2005.
199.
“Nicotine Sublingual Spray for Smoking Cessation”. By Peter A. Crooks, Abeer M.
Al Ghananeem, and Ahmad Malkawi, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Properties Committee, November 17th, 2005.
200.
“Analgesics and methods of Use”. By Richard Smith-Carliss, Frank S. Caruso,
PeterA. Crooks, Kenneth J. Keller, and Yingxian Xiao, People’s Republic of China
Patent Application No. CN 1,612,732, May 4th, 2005.
201.
“Substituted Arylidenamino Guanidines for Use as Selective NMDA Receptor
Inhibitory Modulators”. By Peter A. Crooks, John L. Littleton, Joshua R. Ring, and
Sundar Neelakantan, U.S. Patent Application, submitted to the University of
Kentucky Intellectual Properties Committee, November 5th, 2005, Case No. 1374, filed
as a U.S. Provisional patent, 2005.
202.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner,
Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S. Patent No. US
6,958,399, October 25th, 2005.
203.
“bis-Pyridino-containing Compounds for the Use in the Treatment of CNS Pathologies”.
By Peter A. Crooks, Linda P. Dwoskin, Joshua T. Ayers, Vladimir Grinevich, and
Sangeetha P. Sumithran, U.S. Patent Application No. US2005/0261334 A1, November
24th, 2005.
204.
“Synergistic Enhancement of Opioid Analgesia and Attenuation of Opioid Tolerance and
Dependence by Combination with Racemic (+/-) Norketamine, S(-)-Norketamine and
R(+)-Norketamine”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application,
submitted to the University of Kentucky Intellectual Properties Committee, Case No.
1380.November 17th, 2005,
205.
“Novel Synergistic Opioid-Cannabinoid Codrug Combinations for Pain Management.” By
Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Properties Committee, Case No. 1392, December 8th,
2005.
206.
“Novel tris-Quaternary Ammonium Salts that Interact with Neuronal Nicotinic Receptors”.
By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, Roger Papke, Sangeetha
Sumithran, U.S. Patent Application, US 60/753,970, December 12th, 2005.
151
207.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner,
Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S. Patent No. US 6,979,695
B2, December 27th, 2005.
208.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, Australian Patent Application No. AU
2004257696, January 27th, 2005.
209.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, Canadian Patent Application No. CA
2,532,229, January 27th, 2005.
210.
“Derivados de Azatriciclo[3.3.1.1]decano y Composiciones Farmaceuticas que los
Contienen" By Peter A. Crooks, Mexican Patent No. MX PA 00009634 A, June 20th,
2005.
211.
“Co-Pharmaka als ein verfarhane des Kontrollierten Arzneimittel Transportes“. By Paul
Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska,
and Hong Guo, German Patent No. DE 69433818T2, June 16th, 2005
212.
“Arylsubstituierte Olefinische Amine und ihre Verwendung als Cholinergische
Rezeptoragonisten“. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti,
Srishailkumar B. Hadimani, Haeil Park, Jared M. wagner, Peter A. Crooks, Patrick M.
Lippiello, and Merouane Bencherif, German Patent No. DE 69919537T2, August 9th,
2005.
213.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, International Patent Application No. WO
2005/007103 A2, January 27th, 2005.
214.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, Peter A. Crooks, U.S. Patent Application No. US
2005/0282846 A1, December 22nd, 2005.
215.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent Application No. US20050272716 A1, December 8th, 2005.
216.
“R(+)- and S(-)-Nornicotine for the treatment of Pain”. By Joseph R. Holtman, Peter A.
Crooks, Linda P. Dwoskin, and Elzbieta P. Wala, U.S. Patent Application, submitted to
the University of Kentucky Intellectual Properties Committee, November 17th, 2005, Case
No. 1377 filed as a U.S. Provisional Patent No. US 60/859,488, November 17th, 2006 .
217.
“Synergistic Enhancement of Opioid Analgesia Combination with S(-)- and R(+)Nornicotine”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application,
submitted to the University of Kentucky Intellectual Properties Committee, November
17th, 2005, Case No. 1379 filed as a U.S. Provisional Patent No. US 60/xxx,xxx,
December 11th, 2006.
218.
“bis-Quaternary Ammonium Compounds that Interact with Neuronal Nicotinic Receptors”.
By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, and Sangeetha Sumithran,
UK Case No. 1401; U.S. Patent Application, US 60/758,622, January 13th, 2006.
152
219.
“Method for Treatment of Cancer”. By Peter A. Crooks and Robert Alonso, U.S.
Patent Application No. US2006/0009468, January 12th, 2006.
220.
“mono-Quaternary Ammonium Compounds that Interact with Neuronal Nicotinic
Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda P.
Dwoskin,
and Sangeetha Sumithran, U.S. Patent Application, US 60/814,423, July 14th, 2006.
221.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, European Patent Application No. EP
4,777,849.3-2123, February 2nd, 2006.
222.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, European Patent Application No. EP
1643984, April 4th, 2006.
223.
“Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Canadian Patent
No. CA2600468, September 9th, 2006.
224.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. 7,045,538, May 16th, 2006.
225.
“Enhancing Transdermal Delivery of Opioid Antagonists and Antagonists Using Codrugs
Linked to Bupropion or Hydroxybupropion” Peter A. Crooks, Audra L. Stinchcomb,
Mohamed O. Hamad, and Paul K. Kiptoo, U.S. Patent Application, submitted to the
University of Kentucky Intellectual Properties Committee, Case No. 1426 (docket no.
1028750-000274), May 25th, 2006.
226.
“bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal
Nicotinic Receptors” By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa
Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No. 1429,
U.S. Provisional Patent Application, US 60/799811, May 12th, 2006.
227.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, and Peter A. Crooks, Canadian Patent Application No. CA 2,501,335,
April 4th, 2006.
228.
"Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use in the
Treatment of CNS Pathologies." By Peter A. Crooks, Linda P. Dwoskin, Rui Xu,
and Joshua T. Ayers, U.S. Patent No. US 7,091,357 B2, August 15th, 2006.
229.
“Scopolamine Sublingual Spray for the treatment of Motion Sickness.” By Peter A.
Crooks, Abeer Al-Ghananeem, and Ahmad H. Malkawi, U.S. Patent Apllication No.
US2006/0193784 A1, August 31st, 2006.
230.
“Scopolamine Sublingual Spray for the treatment of Motion Sickness.” By Peter A.
Crooks, Abeer Al-Ghananeem, and Ahmad H. Malkawi, International Patent Application
No. WO 2006/093786, September 8th, 2006.
153
231.
“Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, U.S. Patent
Application No. US2006/0205694 A1, September 14th, 2006.
232.
“Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, International
Patent Application No. WO 2006/099385, September 21st, 2006.
233.
“Novel Synergistic Opioid-Cannabinoid Codrug for Pain Management.” By Joseph R.
Holtman and Peter A. Crooks (Docket No. 13177N/060236), U.S. Patent Application No.
US60,828,960, October 10th, 2006.
234.
“Lofexidine Enantiomers for Use as a Treatment for CNS Diseases and
Pathologies”. By George A. Digenis, Peter A. Crooks, and Abeer M. Al
Ghananeem, U.S. Patent Application No. 11,376,710, filed March 14th, 2006.
235.
“Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, Korean Patent Application No. KR
1020060037340, May 3rd, 2006.
236.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M. Wagner,
and Peter A. Crooks, U.S. Patent Application No. US 2006/0264445 A1, November 23rd,
2006.
237.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M. Wagner,
and Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S. Patent Application
No. US 2006/0293289 A1, December 28th, 2006.
238. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Australian Patent
Application No. AU2006223076 September 21st, 2006.
239. “Sublingual Spray for the Treatment of Pain.” By Peter A. Crooks, Abeer Al-Ghananeem,
and Ahmad H. Malkawi, International Patent No. WO 2006/105205, October 5th, 2006.
240.
“Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,
Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. 7,060,826, June 13th, 2006.
241
“bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda
P. Dwoskin, Sangeetha Sumithran, and Marharyta Pivavarchyk, UK Case No. 1439;
U.S. Provisional Patent Application 60/814640, May 31, 2007.
242.
“Use of Substituted (Z)/(E)-2-(1H-Indole-3-ylmethylene)azabicyclo[2.2.2]octane-3ones and Related Compounds as Radiosensitization Agents”. By Peter A. Crooks,
Vijayakumar N. R. Sonar, Michael L. Freeman, Sekhar R. Konjeti, and Joseph L.
Roti Roti, U.S. Patent Application, submitted to the University of Kentucky
Intellectual Properties Committee, November 17th, 2005, Case No. 1475, filed as a U.S.
provisional patent No. US60/879,895, January 11th, 2007.
243. “Use of Substituted (Z)- and (E)-2-(1-Benzyl-1H-indol-3-yl)azabicyclo[2.2.2]octan-3-ols
154
and Related Compounds as Radio-sensitizing Agents with Synergystic Antiangiogenic
Properties.” By Peter A. Crooks, Vijayakumar N. R. Sonar, Michael L. Freeman, Sekhar
R. Konjeti, and Joseph L. Roti Roti, U.S. Patent Application, submitted to the University
of Kentucky, Intellectual Properties Committee, September 5th, 2006, Case no. 1458,
filed as a U.S. provisional patent No. US60/878,735, January 5th, 2007.
244. “tetrakis-Quaternary Ammonium Compounds that Interact with Neuronal Nicotinic
Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Zheng, Zhenfa, Marharyta
Pivavarchyk, submitted to the University of Kentucky Intellectual Properties Office, Case
No. 1494, April, 2007, filed as a US Provisional Patent No. 61/001,196. October 31,
2007.
245. “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin,
and Sangeetha Sumithran, UK Case No. 1401; filed as a U.S. Utility Patent Application
January 12th, 2007.
246.
“bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda
P. Dwoskin, Sangeetha Sumithran, and Marharyta Pivavarchyk, UK Case No. 1439; filed
as a U.S. Utility Patent Application May 31, 2007.
247.
“bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal
Nicotinic Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa
Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No. 1429,
Filed as a U.S. Utility Patent Application, May 12th, 2007.
248.
“Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with
Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong
Guo, and Paul Ashton, U.S. Patent No. US 7,214,710, May 8th, 2007.
249.
“Synergistic Combinations of Norketamine and Opiate Analgesics”. By Joseph R.
Holtman and Peter A. Crooks, U.S. Patent Application No. US 11/558,782, November
10th, 2007.
250.
“Compounds of Use in the Treatment of Epilepsy, Seizure and Electroconvulsant
Disorders”. By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S.
Patent No. 7,226,949, June 5th, 2007.
251. “Method for Enantioselectively Forming R-(+)-Nornicotine or S-(-)-Nornicotine”.
By Marhaba Hojahmat, Xiaochen Wei and Peter A. Crooks, Docket No.
Yaup-1960, Filed as a U.S. Provisional Patent, May, 2007.
252.
“Synergistic Combinations of Norketamine and Opioid Analgesics”. By Joseph R. Holtman
and Peter A. Crooks, International Patent No. WO 2007/059445 A2, May 24th, 2007.
253.
“Analgesics and Methods of Use”. By Richard Smith-Carliss, Frank S. Caruso, Peter A.
Crooks, Kenneth J. Kellar, and Yingxian Xiao, U.S. Patent Application No. US
2007/0129434 A1, June 7th, 2007.
254.
“tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin,
Roger Papke, and Sangeetha Sumithran, International Patent No. WO 2007/076112 A2,
July 5th, 2007.
155
255.
“Analgetic Pyrroline Derivatives”. By Yingxian Xiao, Peter A. Crooks, Richard Smith-Carliss,
Kenneth J. Kellar, Frank S. Caruso, Australian Patent Application No. AU 2002326806 B,
July 19th, 2007.
256. “bis-Quaternary Ammonium Salts and methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
and Sangeetha Sumithran, International Patent No. WO 2007/094912, August 23rd,
2007.
257. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, US Patent
Application No. 11/908,531, September 13th, 2007.
258. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, European Patent
Application No. EP06738150.9-1211, October 19th, 2007.
259. “Novel Synergystic Opioid-Cannabinnoid Codrugs for Pain Management”. By Joseph R.
Holtman, Peter A. Crooks, and Harpreet Dhooper, US Patent Application No. US
11/973,818, October 10th, 2007.
260. “bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
Zhenfa Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No.
1429, International Patent No. WO 2007/133614, November 22nd, 2007.
261. “Opioid-Norketamine Codrug Combinations for Pain Management”. By Joseph R.
Holtman and Peter A. Crooks, UK Case No.1555, U.S. Provisional Patent Application
No. 61/072090, March 27th, 2008.
262. “Opioid-Nornicotine Codrug Combinations for Pain Management”. By Joseph R.
Holtman and Peter A. Crooks, UK Case No.1554, U.S. Provisional Patent Application
No. 61/072091, March 27th, 2008.
263. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin, and Abeer M. Al
Ghananeem, European Patent No. EP1858864, November 28th, 2007.
264. “Use of Lobeline Diastereomers in the Treatment of Central nervous System Diseases,
Pathologies, and Drug Abuse”. By Peter A. Crooks, Linda P. Dwoskin, and David R.
Worthen, U.S. Provisional Application No. 60/985,189, November 2nd, 2007.
265. “Substituted Arylidenamino Guanidines for Use as Selective NMDA Receptor
Inhibitory Modulators”. By Peter A. Crooks, John L. Littleton, Joshua R. Ring, and
Sundar Neelakantan, U.S. Patent Application No. 60/884,365, January 10th, 2007.
266. “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell,
Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M.
Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, U.S. Patent
No. US 7,307,092, December 11th, 2007.
267. “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A.
Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent No. US 7,312,242, December
156
25th, 2007.
268. “Extraction and Quantitation of Parthenolide from Tanacetum parthenium (Feverfew
Plant), Followed by Direct Derivitization to the Antitumor Drug, LC-1”. By Peter A. Crooks
and Sundar Neelakantan, U.S. Patent Application, submitted to the University
of Kentucky, Intellectual Properties Committee, UK Case No. 1552, December 13th,
2007.
269. “mono-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acertylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
angeetha Sumithran, and Zhenfa Zhang, International Patent No. WO 2007/149392,
December 27th, 2007.
270. “Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Zhenfa, Zheng
Guangrong Zheng, Sangetha and Marharyta Pivavarchyk, International Patent No. WO
2007/149163, December 27th, 2007.
271. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin and Abeer M. Al
Ghananeem, Korean Patent No. KR 2007/0120163, December 21st, 2007.
272. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Same”. By
Robert Alonso, Peter A. Crooks, Barry M. Walker, and David R. Worthen, Docket No.
Yaupon 2010, Continuation-in-part, Provisional US Patent Application 61/039,840,
March 27th, 2008.
273.
“Novel Synergistic Opiod-Cannabinnoid Codrug for Pain Management”. By Joseph R.
Holtman and Peter A. Crooks, International Patent No. WO2008/045556, April 17th,
2008.
274. “2,6-Disubstituted Piperidines and Piperazine Compounds”. By Peter A. Crooks,
Linda P. Dwoskin, Guangrong Zheng, Dennis K. Miller, Seth D. Norholm,
Krishnan Sairam, and Marlon D. Jones, U.S. Patent No. 7,368,443, May 6th, 2008.
275. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Chinese Patent
No. CN 101175735, May 7th, 2008.
276. “Nornicotine for the Treatment of Pain”. By Joseph R. Holtman, Peter A. Crooks, Linda P.
Dwoskin, and Elzbieta P. Wala, International Patent No. WO 2008/063556, May 29th,
2008.
277. “Synergistic Combinations of Norketamine and Opiod Analgesics”. By Joseph R. Holtman
and Peter A. Crooks, US Patent Application No. 2008/0132531 A1, June 5th, 2008.
278. “Synergisitic Effects of Combinations of Nornicotine and Opioids for Treatment of Pain”.
By Joseph R. Holtman and Peter A. Crooks, International Patent No. WO 2008/073381,
June 19th, 2008.
279. “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner,
and Peter A. Crooks, US Patent Application 2008/0139809, June 12th, 2008.
157
280. “Synergistic Combinations of Norketamine and Opioid Analgesics”. By Joseph R.
Holtman and Peter A. Crooks, Australian Patent Application No. AU 2006/315201, May
24th, 2007.
281. “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, and
Sangeetha Sumithran, U.S. Patent Application No. US 12/160,713, July 11th, 2008.
282. “tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin,
Roger Papke, and Sangeetha Sumithran, U.S.Patent Application No. 12,158,192,
June 19th, 2008.
283. “Novel Synergistic Opioid-Cannabinnoid Codrug for Pain Management”. By Joseph R.
Holtman, Peter A. Crooks and Dhooper Harpreet, U.S. Patent Application Patent No.
US2008/0176885, July 24th, 2008.
284. “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By
Robert Alonso, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin and Abeer M. Al
Ghananeem, U.S. patent Application No. US2008/0194699, August 14th, 2008.
285. “Analgetic Uses of Norketamine and Ketamine/Norketamine Prodrugs”. By Peter A.
Crooks and Miguel Rivera, New Zealand Patent Application No. NZ5440282, June 30th,
2008.
286. “Synergistic Combinations of Norketamine and Opioid Analgesics”. By Joseph R.
Holtman and Peter A. Crooks, Canadian Patent Application No. CA 2629347, May
24th, 2007.
287. “Synergistic Combinations of Norketamine and Opioid Analgesics”. By Joseph R.
Holtman and Peter A. Crooks, European Patent Application No. EP 1962589, September
3rd, 2008.
288. “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary
M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner,
and Peter A. Crooks, US Patent Application 2008/0214628 A1, September 4th, 2008.
289. “Use of Substituted 5-((N-Benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)triones
and (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and
Related Compounds as Radiation Sensitizing Agents with Synergistic Anti-Angiogenic
Properties”. By Peter A. Crooks, Thirapathi R.Y. Reddy, Narisimha R. Penthala, Michael
L. Freeman and Raja S. Konjeti, Docket No. PAC-0001, US Provisional Patent Application
No. 61/194,754, filed September 30th, 2008.
290. “Method for the Enantioselective Synthesis of (+)- and (-)-2-[1-(2,6-Dichlorophenoxy)ethyl]-1,3-diazacyclopent-2-ene”. By Peter A. Crooks and Ashish P. Vartak, Docket No.
PAC-0002, US Provisional Patent Application No. 61/195,309, filed October 6th,
2008.
291. “Pyrrolidine Based Analogs for the Inhibition of Dopamine Uptake by the Vesicular
Monoamine Transporter 2 (VMAT2) Protein”. By Peter A. Crooks, Ashish P. Vartak,
Jaturaporn Chagkutip, Agripina G. Deaciuc, and Linda P. Dwoskin, Docket No. PAC 0003,
US Provisional Patent Application No. 61/xxx,xxx, filed October 6th, 2008.
158
292. “Unsaturated Thiadiazolidinone Derivatives as Antileukemic Agents”. By Peter A. Crooks,
Shama Nasim, Monica Guzman and Craig T. Jordan, Docket No. PAC 0004, US
Provisional Patent Application No. 61/195,554, filed October 8th, 2008.
293. “Use of tris-Quaternary Ammonium Salts as Pain Modulating Agents”. Peter A. Crooks,
Joseph R. Holtman, Linda P. Dwoskin, and J. Michael McIntosh, Docket No. PAC 0005,
US Provisional Patent Application No. 61/195,824, filed October 10th, 2008.
294. “Differential Inhibition of Acetylcholine-evoked Responses of Neuronal Nicotinic
Receptors in Rat Brain Slices by Selective nAChR Antagonists”. By Gretchen Y.
López, Jeffrey S. Thinschmidt, Guangrong Zheng, Zhenfa Zhang, Peter A.
Crooks, Linda P. Dwoskin, and Roger L. Papke, Docket No. PAC 0006, US Provisional
Patent Application No. 61/195,820, filed October 10th, 2008.
295. “tetrakis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Zheng, Zhenfa,
Marharyta Pivavarchyk, US Patent Application No. US 12/260,502, filed October 29th,
2008.
296. “Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists".
By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner,
Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell,
and Haeil Park, Japanese Patent No. JP 2008/255122 A, October 30th, 2008.
297. “Process Development for the Synthesis of Bupropion Hydrochloride and Hydroxybupropion
via Efficient Bromination using N-Bromosuccinimide”. By Peter A. Crooks, Thirapathi R.Y.
Reddy, Narisimha R. Penthala, Nikhil R. Madadi, and Rajitha Bavanthula, Docket No.
PAC 0007, US Provisional Patent Application No. 61/198,802, filed November 10th, 2008.
298. “bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
Sangeetha Sumithran, David D. Allen, Zhenfa Zheng, and Paul Lockman, US Patent
Application No. US 12/300,197, filed November 20th, 2008.
299. “bis-Pyridino Containing Compounds for the Use in the Treatment of CNS Pathologies”. By
Peter A. Crooks, Linda P. Dwoskin, Joshua Ayers, Vladimir Grinevich, and Sangeetha
Sumithran, US Patent Application No. 2008/0287490, November 20th, 2008.
300. “Use of tetrakis-Quaternary Ammonium Salts as Pain Modulating Agents”. By Peter A.
Crooks, Joseph R. Holtman, Linda P. Dwoskin, and J. Michael McIntosh, Docket No. PAC
0008, US Provisional Patent Application No. 61/200,969, filed December 5th, 2008.
301. “bis-Tertiary Amines and Methods for Modulating Neuronal Nicotinic Acetylcholine
Receptors”. By Peter A. Crooks, Ph.D., Linda P. Dwoskin, Zhenfa Zhang, Marharyta
Pivavarchyk, and Andrew Smith, Docket No. PAC 0010, US Provisional Patent Application
No. 61/212,162, filed December, 2008.
302. “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
and Sangeetha Sumithran, U.S. Patent Application No. US 12/304,948, December 15th,
2008.
303. “mono-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acertylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng,
159
Sangeetha Sumithran, and Zhenfa Zhang, U.S. Patent Application No. US 12/304955,
December 15th, 2008.
304. “tris- and tetrakis-Tertiary Amines and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Ph.D., Linda P. Dwoskin, Zhenfa Zhang,
and Marharyta Pivavarchyk, Docket No. PAC 0011, US Provisional Patent Application No.
61/212,187, filed April 8th, 2009.
305. “Lofexidine Enantiomers for Use as a Treatment for CNS Diseases and
Pathologies and its Chiral Synthesis”. By George A. Digenis, Peter A. Crooks, and
Abeer M. Al Ghananeem, U.S. Patent Application No. US 2008/319041 A1, December
25th, 2008.
306. “Aryl-substituted Olefinic Amines and Aryl-substituted Olefinic Amines Cholinergic
Receptor Agonists". By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared
M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S.
Caldwell, and Haeil Park, Japanese Patent No. JP 2008/260774 A, October 30th, 2008.
307. “Enhancing Transdermal Delivery of Opioid Antagonists and Agonists Using Codrug
Links to Bupropion or Hydroxybupropion”. By Audra L. Stinchcomb, Peter A. Crooks,
Mohamed O. Hamad, and Paul Kiptoo, US Patent Application No. 2009/0017102,
January 15th, 2009.
308. “Synthesis and Hydrolysis Studies of a (-)-Cytisine-Naltrexone Carbamate Codrug for
Transdermal Drug Delivery”. By Peter A. Crooks, Joshua Eldridge, and Audra
Stinchcomb, UK Intellectual Properties Committee, UK Case No. 1643, February 10th,
2009.
309. “Analgesic Uses of Norketamine and Ketamine/norketamine Prodrugs”. By Peter A.
Crooks and Miguel L. Rivera, European Patent No. EP 2027854 A1, February 25th,
2009.
310. “N-2,3-Dihydroxypropyl Analogs of nor-Lobelane and Related Compounds for the
Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central
Nervous System Diseases and Pathologies”. Peter A. Crooks, Linda P. Dwoskin,
Guangrong Zheng, Ashish P. Vartak, and David B. Horton, Docket No. PAC-0012, US
Provisional Patent Application No., 61,268,472, filed June 12th, 2009.
311. “An Economical Synthesis of Fluridone”, Peter A. Crooks, Ashish P. Vartak, and L. Jeffry
Lawrence. Docket No. Profix-001, US Provisional Patent Application No. 61/215,057, filed
May 1st, 2009.
312. “Use of Lobeline Epimers in the Treatment of Central Nervous System Diseases,
Pathologies, and Drug Abuse”. Peter A. Crooks and Linda P. Dwoskin, US Patent
Application No. US2009/118331 A, May 7th, 2009.
313. “Sublingual Spray for the Treatment of Pain”. Peter A. Crooks, Abeer Al-Ghananeem, and
Ahmad Malkawi, US Patent Application No. US2009/117054 A1, May 7th, 2009.
314. “Use of Lobeline Epimers in the Treatment of Central Nervous System Diseases,
Pathologies, and Drug Abuse”. Peter A. Crooks and Linda P. Dwoskin, International
Patent No. WO2009/059,260A, May 7th, 2009.
315. “Nornicotine for the Treatment of Pain”. By Joseph R. Holtman, Peter A. Crooks, Linda P.
160
Dwoskin, and Elzbieta P. Wala, US Patent Application No. 12/515,152, May 15th, 2009.
316. “tetrakis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Zheng, Zhenfa,
Marharyta Pivavarchyk, US Patent Application No. US 2009/143424, June 4th,
2009.
317. “Analgetische Verwendung von (S)-Norketamin”. By Peter A. Crooks and Miguel Rivera,
Austrian Patent No. AT432697, June 15th, 2009.
318. “Synergistic Effects of Combinations of Nornicotine and Opioids for Treatment of Pain”. By
Joseph R. Holtman, and Peter A. Crooks, US Patent Application No. 12/518,562, June
10th, 2009.
319. “1-[3’-(trifluoromethyl)phenyl]-3-phenyl propanone”. By Ashish P. Vartak, Jeffry Lawrence
and Peter A. Crooks Docket No. Profix-002, US Provisional Patent Application No.
61/xxx.xxx, filed June 30th, 2009.
320. “Analgesic Uses of (S)-Norketamine”. By Peter A. Crooks and Miguel L. Rivera, European
Patent No. EP 1567145 B1, June 6th, 2009.
321. “Opioid-nornicotine Codrugs for Pain Management”. By Joseph R. Holtman, Peter A.
Crooks, and Ujjwal Chakraborty, International Patent No. WO2009/121018, October 1st,
2009.
322. “Analgesic Uses of (S)-Norketamine”. By Peter A. Crooks and Miguel L. Rivera, Hong
Kong Patent No. HK 1079461, August 14th, 2009.
323. “Stabilized Compositions of Alkylating Agents and Methods of Using Same”. By Robert
Alonso, Barry R. Walker, and Peter A. Crooks, International Patent No. WO
2009/120493, October 1st, 2009.
324. “Indole Compounds and Their Use as Radiation Sensitizing Agents and Chemotherapeutic
Agents”. By Peter A. Crooks, Thirupathi R. YerramReddy, Narsimha R. Reddy, Michael L.
Freeman and Narsimha R. Penthala, Michael L. Freeman, and Sekhar R. Konjeti, US Patent
Application No. US 12/571,425, September 30th, 2009.
325. “Enantioselective Synthesis of (+)- and (-)-2-[1-(2,6-Dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene”. By Peter A. Crooks and Ashish P. Vartak, US Patent Application No.
US 12/574,578, filed October 6th, 2009.
326. “Use of Tris-Quaternary Ammonium Salts as Pain Modulating Agents”. By Joseph R.
Holtman, Peter A. Crooks, Linda P. Dwoskin, and J. Michael McIntosh, US Patent
Application No. US 12/576,300, October 9th, 2009.
327. “bis-Quaternary Ammonium Salts as Pain Modulating Agents”. By Joseph R. Holtman,
Peter A. Crooks, Linda P. Dwoskin, and J. Michael McIntosh, US Provisional Patent
Application No. 61/xxx.xxx, filed October 15th, 2009.
328.
“Stabilized Compositions of Alkylating Agents and Methods of Using Same”. By Robert
Alonso, Barry R. Walker, Mark Pimley, Stuart Lessin, and Peter A. Crooks, US Patent
Application No. 12/549,258, August 27th, 2009.
329.
“Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management”. By
161
Joseph R. Holtman, Peter A. Crooks, and Ujjwal Chakraborty, International Patent
Application No. WO 2009/131794 A1, October 29th, 2009.
330. “Indole Compounds and Their Use as Radiation Sensitizing Agents and
Chemotherapeutic Agents”. By Peter A. Crooks, Therapathi R. Yerramreddy, Narshima R.
Penthala, Michael L. Freeman, and Sekhar R. Konjeti, US Patent Application No.
12/571,425, September 30th, 2009.
331. “Aryl Substituted Olefinic Amines and Their Use as Cholinergic Receptor Antagonists”. By
Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Balwinder S. Bhatti, Peter A.
Crooks, Patrick M. Lippiello, Gary M. Dull, William S. Caldwell, and Merouane Bencherif,
Canadian Patent No. CA 2677519, December 23rd, 1999.
332. “Bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic
Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, and
Sangeetha Sumithran, US Patent Application N0. US 2009/0318503 A1, December 24th,
2009.
162
XIII
Grant Activity and Research Support
1970-1974
"Semi-Rigid Heterocyclic Compounds with Potential Analgesic Activity", Imperial Chemical
Industries, Alderely Park, England, 1972-1975, $18,000 (approximate U.S. equivalent) (P.I.
Peter A. Crooks).
Pharmaceutical Society of Great Britain Award for Graduate Student Support for the Project "Synthesis and Pharmacological Profile within the CNS of Some Rigid and Semi-Rigid
Analogues of Phenylethylamines", 1972, $14,000 (approximate U.S. equivalent) (P.I. Peter A.
Crooks).
Pharmaceutical Society of Great Britain Award for Graduate Student Support for the Project "Synthesis of Novel Enkephalin Analogues", 1974, $15,000 (approximate U.S. equivalent) (P.I.
Peter A. Crooks).
Society of Great Britain Award for Graduate Student Support for the Project - "Conformationally
Defined Analogues of Dopamine, Tyramine and Phenylethylamine", 1974, $15,000 (approximate
U.S. equivalent) (P.I. Peter A. Crooks).
1975-1979
"Novel, Rigid Phenethylamine Analogues", Imperial Chemical Industries, Alderely Park, England,
1975-1976, $8,000 (approximate U.S. equivalent) (P.I. Peter A. Crooks).
"Rigid Analogues of Dopamine", The Wellcome Foundation, United Kingdom, 1978-1979,
$8,000 (approximate U.S. equivalent) (P.I. Peter A. Crooks).
Science Research Council Award for Graduate Student Support for the Project - "Development
of Transition - State Analogue Inhibitors of DNA Adenine N6-Methyltransferase", 1979, $15,000
(approximate U.S. equivalent) (P.I. Peter A. Crooks).
"Synthesis of Novel Heterocycles from Ninhydrin", British Council - CNR (Italy), Academic Links
Scheme, 1979-80, $6,000 (approximate U.S. equivalent) (P.I. Peter A. Crooks).
1980-1984
Science Research Council Award for Graduate Student Support for the Project - "Synthesis of
Mechanism - Based Inhibitors of RNA Guanine 7-Methyltransferase", 1980, $15,000
(approximate U.S. equivalent) (P.I. Peter A. Crooks).
"Synthesis and Evaluation of Methyltransferase Inhibitors", Science Research Council,
1981-1982, $12,000 (approximate U.S. equivalent) (P.I. Peter A. Crooks).
"Role of Methylation in Nicotine Toxicity", Tobacco and Health Research Institute, 1982-1983,
$65,101 (P.I. Peter A. Crooks).
163
"The Role of Methylation in Nicotine Toxicity", Tobacco and Health Research Institute, June
1982-December 1985, $11,799 (P.I. Peter A. Crooks).
"Laboratory Equipment for Research", Biomedical Research Support Grant, 1982, $2,124 (P.I.
Peter A. Crooks) - funded.
"Role of Methylation in Nicotine Toxicity", (2nd year renewal) Tobacco and Health Research
Institute, 1983-1984, $59,677 (P.I. Peter A. Crooks).
"Alterations of Rat Trachea and Lung Polyamine Biosynthesis by Cigarette Smoke
Components", Tobacco and Health Research Institute, 1983-1984, $56,379 (P.I. J. Olson, CoInvestigator, Peter A. Crooks).
"Synthesis and Evaluation of Multisubstrate Adducts as Selective Inhibitors of
Phenylethanolamine-N-methyltransferase", Isabell Kirscher Research Award, 1983-1984,
$5,000.00 (P.I. Peter A. Crooks).
"Development of Irreversible Inhibitors of Aminoalkyltransferases", University of Kentucky
Research Foundation Research Project Award, 1983-1984, $1,500 (P.I. Peter A. Crooks).
"Role of Methylation in Nicotine Toxicity (3rd year renewal), Tobacco and Health Research
Institute, 1984-1985, $66,426 (P.I. Peter A. Crooks).
"Closed-System Metabolic Cages", Tobacco and Health Research Institute - Special Equipment
Award, 1984, $4,598 (P.I. Peter A. Crooks).
"A Campus Facility for the Packing of High-Pressure Liquid Chromatographic Columns", UKMC
Major Equipment Award, 1984, $3,017 (P.I. Peter A. Crooks).
"Metabolic Fate of Dichloroacetonitrile",University of Kentucky Medical Center Research Award,
1984-1985, $4,230 (P.I. Peter A. Crooks).
1985-1989
"An In Vivo Study of the Effect of Chronic Nicotine Administration on Tissue and Plasma Levels
of Histamine", Tobacco and Health Research Institute, 1985, $19,917 (P.I. Peter A. Crooks).
"Role of Methylation in Nicotine Toxicity - Potential Toxicity of N-Methylnicotinium Ion", Tobacco
and Health Research Institute, January 1986 - December 1986, $24,382 (P.I. Peter A. Crooks).
"Chromatographic Resolution of (± )-[14C-2']-Nicotine", R.J. Reynolds Tobacco Company, 19871988, $14,748 (P.I. Peter A. Crooks).
"(± )-[14C-2']-Nicotine", R.J. Reynolds Tobacco Company, 1987, supplied as a gift (value
$33,780) (P.I. Peter A. Crooks).
"Nicotine Methylation Studies", Tobacco and Health Research Institute, January 1 to June 1987,
$11,748 (P.I., Peter A. Crooks).
"Super HPTLC System", University of Kentucky Bond Issue Equipment Proposal, 1987, $50,000
(P.I. Peter A. Crooks).
164
"Metabolism and Pharmacology of Triazoline Anticonvulsants", National Institutes of Health,
1987-1990, $170,493 (P.I. Pankaja K. Kadaba, Co-Investigator, Peter A. Crooks).
"Liquid Chromatography Flow-Through Optical Activity Detector", University of Kentucky Bond
Issue Equipment Proposal, 1987, $20,158 (P.I. Peter A. Crooks).
"Diode Array Flow-Through Rapid Spectrum Detector", University of Kentucky Bond Issue
Equipment Proposal, 1987, $18,900 (P.I., Peter A. Crooks).
"Gradient High Performance Liquid Chromatography System", University of Kentucky Bond
Issue Equipment Proposal, 1987, $10,222 (P.I. Peter A. Crooks).
"Research Personnel Support Grant", Tobacco and Health Research Institute, July, 1987,
$1,500 (P.I. Peter A. Crooks).
"Development of New Antiviral Agents", Faculty Development Program Support, 1988, $4,500
(P.I. Peter A. Crooks).
"Synthesis of Nicotine Derivatives", R.J. Reynolds Tobacoo Company, 1988-1989, $35,535 (P.I.
Peter A. Crooks).
"Synthesis of Inhibitors of Phenylethanolamine N-Methyltransferase as Prototypes for the
Development of Antihypertensive Agents", Southern Research Institute, March, 1989, $9,500
(P.I. Peter A. Crooks, Co-P.I. S. Niwas).
"Synthesis of Nicotine Derivatives", (Second Year) R.J. Reynolds Tobacco Company, $38,378,
1989-1990 (P.I. Peter A. Crooks).
1990-1994
"Practical Approaches to Enhancing the Stability of Aspartame in Aqueous Solutions", The
Nutrasweet Company, 1990-1991, $50,625, (P.I. Anwar A. Hussain, Co-P.I. Peter A. Crooks).
"Development of Novel Antisense Oligonucleotides", UKMC Major Equipment Research Fund,
January 1990 to December 31, 1990, $19,352 (P.I. Peter A. Crooks, Co-Investigator, R.M.
Riggs).
"Synthesis of Glucuronide Conjugates of Nicotine, Cotinine and 3'-Hydroxycotinine", R.J.
Reynolds Tobacco Company, $25,080, 1990-1992 (P.I. Peter A. Crooks).
"Development of Antisense Oligonucleotides with Potential Chemotherapeutic Value in the
Treatment of AIDS", Biomedical Research Support Grant, NIH, $3,900, 1990-1991 (P.I. Peter A.
Crooks).
"Pharmaceutical Preparations for Addiction Treatment," National Institutes of Health, NIDA,
1991-1996, $1,936,422, (P.I. Rajinder Matharu, Co-P.I., Peter A. Crooks).
"CNS Pharmacology of Nicotine and Its Metabolites", Tobacco and Health Research Institute,
1991-1992, $54,000 (P.I. Linda Dwoskin, Co-P.I. Peter A. Crooks).
165
"Synthesis of Compounds as Therapeutic Agents in Alzheimer's Disease", R.J. Reynolds
Tobacco Company, 1992-1993, $83,000 (P.I. Peter A. Crooks).
"CNS Pharmacology of Nicotine and Its Metabolites", Tobacco and Health Research Institute,
1992-1993, $56,442, 2nd year renewal (P.I.s Linda Dwoskin, Peter A. Crooks).
"Nasal Absorption of Oxymetazoline, Azatadine Hydrochloride and Chlorpheniramine Maleate in
Rats Using In-Vivo In-Situ Technique", Schering-Plough Health Care Products, 4-1-92 to 10-192, $44,000 (P.I's. Dr. Anwar Hussain, Dr. Peter A. Crooks).
"Synthesis of Compounds as Therapeutic Agents in Alzheimer's Disease", R.J. Reynolds
Tobacco Company, 1993-1994, $130,000, 2nd year renewal (P.I. Peter A. Crooks).
"Synthesis of Prodrugs for Ophthalmic Delivery", Control Delivery Systems, Inc., 1993-1994,
$71,520, (P.I. Peter A. Crooks, Co-P.I. Robert M. Riggs).
"Synthesis of dl-NAM and Related Amino Acid Nitrogen Mustards", NIH, National Institute on
Aging, 1993-1996, $50,000, for contract synthesis (P.I., Peter A. Crooks).
"CNS Pharmacology of Nicotine and its Metabolites", Tobacco and Health Research Institute,
1993-1994, $63,692, 3rd year renewal, (P.I.'s Linda Dwoskin, Peter A. Crooks).
"Synthesis of Prodrugs for Ophthalmic Delivery", Control Delivery Systems, Inc., 1994-1995,
$86,058, 2nd year renewal (P.I. Peter A. Crooks).
"Synthesis of Compounds as Therapeutic Agents in Alzheimer's Disease", R.J. Reynolds
Tobacco Company, 1994-1995, $130,000, 3rd year renewal (P.I. Peter A. Crooks).
"CNS Pharmacology of Nicotine and its Metabolites", Tobacco and Health Research Institute,
1994-1995, $71,639 (P.I.'s Linda Dwoskin and Peter A. Crooks), fourth year renewal.
"Enantioselective Synthesis of Nornicotine", UKMC Research fund, 1994-1995, $9,500 (P.I.
Peter A. Crooks).
1995-1999
"Synthesis of Prodrugs for Ophthalmic Delivery", Control Delivery Systems, Inc., 1995-1996,
$107,100, 3rd year renewal (P.I. Peter A. Crooks).
"Synthesis of Compounds as Therapeutic Agents in Alzheimer's Disease", R.J. Reynolds
Tobacco Company, 1995-1996, $131,000, 4th year renewal (P.I. Peter A. Crooks).
"CNS Pharmacology of Nicotine and its Metabolites", Tobacco and Health Research Institute,
$79,705, 7/01/95 to 6/30/96 (Co P.I.s Linda Dwoskin and Peter A. Crooks), fifth year renewal.
"Acylated Amino Acids and Peptides: Use as Antioxidants and Emulsifiers in Foods",
NRICGP/CSRS/USDA, $137,236.75, 9/15/95 to 9/30/96, (P.I. Clair L. Hicks, Co.P.I., Peter A.
Crooks).
166
"Synthesis of Prodrugs for Ophthalmic Delivery", Control Delivery Systems, Inc., 3/1/96 2/28/97, $124,220, 4th year renewal (P.I. Peter A. Crooks).
"CNS Pharmacology of Nicotine and its Metabolites", Tobacco and Health Research Institute,
$83,466, 7/01/96 to 6/30/97 (Co P.I.'s Linda Dwoskin and Peter A. Crooks), sixth year renewal.
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity", Tobacco and Health
Research Institute, Collaborative In-House Project, $155,500, 7/1/96 - 6/30/97, P.I.ís Peter A.
Crooks, Abdulghani Houdi and John Littleton.
"Synthesis of Compounds as Therapeutic Agents in Alzheimer’s Disease," R.J. Reynolds
Tobacco Company, 1996-1997, $181,303, 5th year renewal (P.I.Peter A. Crooks).
"Nornicotine Contribution to the CNS Effect of Nicotine", National Institutes of Health, $421,000
4/01/97 to 3/30/00 (Co P.I.s Linda Dwoskin and Peter A. Crooks).
"Development of Selective Nicotinic Receptor Antagonists", National Institutes of Health,
$989,051, 12/1/97 to 11/30/01 (Co P.I.s Linda Dwoskin and Peter A. Crooks).
"Synthesis of Prodrugs for Ophthalmic Delivery", Control Delivery Systems, Inc., 3/01/972/28/98, $144,900, 5th year renewal (P.I.Peter A. Crooks).
“CNS Pharmacology of Nicotine and its Metabolites", Tobacco and Health Research Institute,
$52,000, 7/01/97-6/30/98 (Co-P.I.s Linda Dwoskin and Peter A. Crooks), seventh year renewal.
"Synthesis of Compounds as Therapeutic Agents in Alzheimer’s Disease." R.J. Reynolds
Tobacco Company, 6/01/97 – 6/30/00, $195,000, (P.I. Peter A. Crooks).
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity." Tobacco and Health
Research Institute, Collaborative In-House Project, $175,000, 7/1/97 – 6/30/98 (P.I.s Peter A.
Crooks, Deane Falcone, and John Littleton), second year renewal.
"Synthesis of Prodrugs for Ophthalmic Delivery." Control Delivery Systems, Inc., 3/01/98 –
2/28/99, $152,680, 6th year renewal, (P.I. Peter A. Crooks).
"CNS Pharmacology of Tobacco Alkaloids." Tobacco and Health Research Institute, $93,792,
7/01/98 – 6/30/99 (CoP.I.s Linda Dwoskin and Peter A. Crooks), eighth year renewal.
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity." Tobacco and Health
Research Institute, Collaborative In-House Project, $163,985, 7/1/98 – 6/30/99 (P.I.s Peter A.
Crooks, Deane Falcone, and John Littleton), third year renewal.
"Research Training in Drug Abuse Behavior." NIDA T32 DA 07304-01, $782,836, 7/1/98-6/30/03
(P.I. Tim F. Garrity, P.G.F. Peter A. Crooks, 5% effort).
"Synthesis of Prodrugs for Ophthalmic Delivery.", Control Delivery Systems, Inc., 3/01/99 –
2/28/03, $172,179, 7th year renewal, (P.I. Peter A. Crooks).
"CNS Pharmacology of Tobacco Alkaloids.", Tobacco and Health Research Institute, $80,000,
7/01/99 – 6/30/00 (Co P.I.s Linda Dwoskin, Peter A. Crooks, Michael Bardo), ninth year renewal.
167
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity." Tobacco and Health
Research Institute, Collaborative In-House Project, $175,000, 7/1/99 – 6/30/00 (P.I.s Peter A.
Crooks, Deane Falcone, and John Littleton), fourth year renewal.
"Preparation of Analgesic Molecules." Endo Pharmaceuticals, Inc. $20,000, 3/01/99-9/30/99.
(P.I.Peter A. Crooks).
"Development of Nicotinic Receptor Antagonist Molecules." Layton Biosciences, Inc. $103,000,
10/1/99 - 9/30/01 (P.I. Peter A. Crooks, CoP.I. Linda Dwoskin).
"Development of Screens for Drugs in Alcohol Dependence." NIH RFA-AA-99-004 (In Vivo
Medication Development for Alcohol–Related Conditions) $2,709,686, 9/30/99-8/31/04 (P.I. J.
Littleton, Co P.I. Peter A. Crooks, 10% effort).
2000-2004
"Enhanced Glycolysis for Hypothermic Heart Preservation." NIH R01 $1,388,298, 7/1/00-6/30/05
(P.I. S. Chien, Co P.I. Peter A. Crooks, 5% effort).
"Development of Novel Therapies for Methamphetamine Abuse." NIDA RO1 $1,158,800,
7/15/00-6/14/04 (P.I. Linda P. Dwoskin, Co. P.I. Peter A. Crooks, 15% effort).
"Graduate Training in Environmental Toxicology" NIEHS $871,302, 7/1/00-6/30/05 (P.I. Mary
Vore, P.G.F. Peter A. Crooks, 5% effort).
"CNS Pharmacology of Tobacco Alkaloids.", Tobacco and Health Research Institute, $60,000,
7/01/00 – 6/30/01 (Co P.I.s Linda Dwoskin, Peter A. Crooks, Michael Bardo), tenth year renewal.
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity." Tobacco and Health
Research Institute, Collaborative In-House Project, $180,000, 7/1/00 – 6/30/01 (P.I.s Peter A.
Crooks, Deane Falcone, and John Littleton), fifth year renewal.
"Preparation of Analgesic Molecules." Endo Pharmaceuticals, Inc. $30,000, 8/01/00-9/30/01.
(P.I.Peter A. Crooks).
"Lobeline Analogs as a Potential Treatment for Drug Abuse." $36,120, 6/15/00-6/14/01, NIH
Predoctoral Fellowship awarded to Marlon D. Jones (1 F31 DA06061), sponsor: Peter A.
Crooks.
"CNS Pharmacology of Lobelia inflata Alkaloids and Related Compounds.", Tobacco and Health
Research Institute, $50,345, 7/01/01 – 6/30/02 (Co P.I.s Linda Dwoskin, Peter A. Crooks,
Michael Bardo).
"Genetic Manipulation of Tobacco Plants to Produce Molecular Diversity." Tobacco and Health
Research Institute, Collaborative In-House Project, $191,153, 7/1/01 – 6/30/02 (P.I.s Peter A.
Crooks, Deane Falcone, and John Littleton), sixth year renewal.
"Novel Nicotine Analogs" Targacept, Inc., 2/01/02 – 1/31/03, $149,167, (P.I. Peter A. Crooks,
10% effort).
168
"Naltrexone Prodrugs for Transdermal Delivery", NIH (NIDA), $1,160,000, 1/1/02 - 12/31/05 (P.I.
Audra Stinchcomb, Co. P.I. Peter A. Crooks, 10% effort).
"Transdermal Crodrugs for Treatment of Alcohol Abuse ", NIH (NIAAA; RFA-AA-02-004, “New
Approaches to Developing Pharmacotherapy for Alcoholism”), $1,149,167, 7/1/02 - 6/30/06
(P.I. Audra Stinchcomb, Co P.I. Peter A. Crooks, 10% effort).
"Development of Bioactive Probes Derived from Bacteriophage", KSEF, $15,000 annual diect
costs, 1/1/02 - 12/31/02 (P.I. Clair Hicks, Co P.I. Peter A. Crooks, 3.5% effort).
"Drug Development Research-Product Development and Formulation", Kentucky Science and
Technology Committeee (KSTC-USWorldMeds), $1,223,862, 6/1/02-9/30/10, $111,871 annual
direct costs, (P.I. Peter A. Crooks, 5% effort).
“Design and Discovery of Novel Subtype-Selective Nicotinic Receptor Agonists and Antagonists,
Utilizing Animal-Free Cell Culture and Microplate Technologies”, International Foundation for
Ethical Research, $15,000 7/1/02-6/30/03, Predoctoral Fellowship awarded to Aaron Hubner,
(Sponsor: Peter A. Crooks, 0% effort).
“Development of Novel Treatments for Nicotine Addiction”, NIH-NIDA (U19; DA017548),
National Coorperative Drug Discovery Groups (NCDDG-MD/NA), $6,600,575, 7/1/03-6/30/08,
(Program Director: Linda P. Dwoskin; P.I.s Linda P. Dwoskin, Peter A. Crooks (40% effort),
Michael T. Bardo). Scientific Core: “Scale-up, Pharmacophore Modeling, Pharmacokinetics and
Metabolism”, $439,823 direct costs, 7/1/03-6/30/08 (P.I. Peter A. Crooks, 10% effort). Project 1:
“Synthesis of Novel Analogs”, $1,063,272 direct costs, 7/1/03-6/30/08 (P.I. Peter A. Crooks,
25% effort). Project 2: “Nicotinic Receptor Subtype Selectivity”, $1,727,763, direct costs, 7/1/036/30/08 (P.I. Linda P. Dwoskin, Co P.I. Peter A. Crooks, 5% effort).
“Post-doctoral Fellowship”, Yaupon Therapeutics, Inc.; $248,085, 7/1/03-12/03/10, (P.I. Peter A.
Crooks, 0% effort).
“Viral Peptides Used to Develop a Model System for Rapid Assay Probes”, KSEF; $202,004,
7/1/03-6/31/05, (P.I. Clair Hicks, CoP.I. Peter A. Crooks, 8% effort).
“Transdermal Delivery of Nornicotine”, KSTC, $100,000, 3/1/03-2/28/04, (P.I. Audra Stinchcomb,
CoP.I. Peter A. Crooks, 16.7% effort).
“Nornicotine Enantiomers and Nicotine Self Adminstration”, NIH/NIDA (STTR); $100,000, 4/1/033/31/04, (P.I. Michael Bardo, CoP.I. Peter A. Crooks, 5% effort).
“Norketamine for Treatment of Pain”, NIH (STTR); $100,000, 11/4/03-10/3/04, (Joseph Holtman
P.I., CoP.I. Peter A. Crooks, 5% effort), funded.
“N-Demethylation of S-(-)-Nicotine as an Economical Source of S-(-)-Nornicotine, a Potential
Smoking Cessation Agent”, NSF/UK Natural Product Alliance, $30,000, 6/1/03-5/31/04, (P.I.
Peter A. Crooks, 5% effort).
“Parthenolides as Potential Treatments for Lung Cancer”, KLCRP; $209,998, 1/1/04-1/31/07,
(P.I. Peter A. Crooks, 2% effort).
169
“Development of Screens for Drugs in Alcohol Abuse”, NIH-NIAAA; $1,886,380 direct costs,
5/1/04-4/30/08, (P.I. John M. Littleton, CoP.I. Peter A. Crooks, 10% effort).
“Training in Drug Abuse Related Research”, NIH/NIDA-K; $1,147,537, 6/1/04-5/31/09. (P.I. Louis
Hersh, P.G.F. Peter A. Crooks, 5% effort).
“Radiosensitization by the Cellular Heat Shock Response”, PPG NIH/NCI; $11,044,020, 7/1/046/30/09, (Program Director, Joseph Roti-Roti) $352,061, 7/1/04-6/30/09, subcontract with the
University of Washington, (P.I. Peter A. Crooks, 2% effort).
“Polyamine Inhibition:a Target for Biodefense in Y. pestis” NIH/SERCEB, $230,000, 10/1/042/28/06. (P.I. Marcos Oliviera, 5% effort).
2005-2009
“Molecular Mechanisms of Toxicity” NIEHS $917,110, 7/1/05-6/30/10 (P.I. Mary Vore, P.G.F.
Peter A. Crooks, 5% effort).
“Nornicotine as a Treatment for Nicotine Abuse”, STTR Phase 2/NIH/NIDA; $166,369, 11/1/0510/30/06. (P.I. Peter A. Crooks, 5% effort).
"Bone-Targeting and Bone Anabolic Compounds", KSTC, 1/1/05-12/31/06 (P.I. William M.
Pierce, CoP.I. Peter A. Crooks, subcontract, $79,200, 1.5% effort).
“Development of Novel Therapies for Methamphetamine Abuse”, NIH/NIDA; $3,101,858,
12/01/05-11/30/10 (P.I. Linda Dwoskin, Co P.I. Peter A. Crooks, 15% effort).
“Pharmacokinetic Studies”. NCI/Vanderbilt University (Subcontract), $31,330, 12/1/05-11/31/06;
(P.I. Peter A. Crooks, 1% effort).
“Naltrexone Prodrugs for Transdermal Delivery”, R01NIH/NIDA; $1,326,306, 7/1/05-30/6/10
(P.I. Audra Stinchcomb, Co P.I. Peter A. Crooks, 10% effort).
“Norketamine for Treatment of Pain” STTR Phase 2/NIH/NIDA, $1,151,689, 3/1/06-2/28/08.
(P.I. Joseph Holtman, CoP.I. Peter A. Crooks, 10% effort).
“Nornicotine Enantiomers for Treatment of Pain”, STTR Phase 1/NIH/NIDA, $216,583, 7/1/066/30/07 (P.I. Joseph Holtman, CoP.I. Peter A. Crooks, 10% effort).
“Subtype-selective Drugs for Nicotinic Receptors from Kentucky Native Plants”, KTDRC
Program, $120,000, 7/1/06-6/30/08 (P.I. John Littleton, CoP.I. Peter A. Crooks, 2% effort).
“Lobeline Epimer Ratio Determination Study”, Yaupon Therapeutics, Inc., $16,406, 4/1/06 to
12/31/07 (P.I. Peter A. Crooks, 0.3% effort).
“Novel Bone Targetting Agents”, Pradama, Inc., $101,811, 7/31/06 to 5/22/08 (P.I. Peter A.
Crooks, 1% effort).
170
“Subtype-selective Drugs for Nicotinic Receptors from Kentucky Native Plants”, KTRDC,
$130,000, 7/1/06 to 6/30/07 (CoP.I. Peter A. Crooks, 2% effort).
”LC-1: A Water-Soluble Parthenolide Analog from Tanacetum parthenium (Feverfew) as a
Potent Anti-tumor Agent”, UK Natural Product Alliance: Cross-Disciplinary Research program in
Natural Products, $43,655, 1/1/07-12/31/07 (P.I. Peter A. Crooks, 3% effort).
“API 2000TM LC/MS/MS System Coupled to a Shimadzu Binary HPLC System”, UK Major
Research Equipment Grant, $134,939, submitted 12/15/06 (P.I. Patrick McNamara; CoP.I. Peter
A. Crooks).
“Water-jacketed CO2 Incubator, Celliject Duo Electroporator, and Inverted Microscope”, UK
Major Research Equipment Grant, $22,101.40, submitted 12/15/06 (P.I. Linda Dwoskin; CoP.I.
Peter A. Crooks).
“A Novel Thiadiazolidine-dione Targets Human Leukemia Stem Cells”, The Leukemia and
Lymphoma Society, $599,780, 10/1/07-30/9/10 (P.I. Craig Jordan, University of Rochester; P.I.
Peter A. Crooks, sub-contract, University of Kentucky), total sub-contract costs: $249,140,
funded.
“Support Formulation Development and Clinical Manufacturing of API and Dosage Form”,
Leuchemix, Inc., $54,990, 5/06/07-10/31/07 (P.I. Peter A. Crooks), funded.
“Development of Novel Treatments for Nicotine Addiction”, NIH-NIDA (U19; DA017548),
National Coorperative Drug Discovery Groups (NCDDG-MD/NA), $7,366,697, 7/1/08-6/30/13,
(Program Director: Linda P. Dwoskin; P.I.s Linda P. Dwoskin, Peter A. Crooks (30% effort),
Michael T. Bardo). Scientific Core: “Scale-up, Pharmacophore Modeling, Pharmacokinetics and
Metabolism”, $861,409 direct costs, 7/1/08-6/30/13 (P.I. Peter A. Crooks, 10% effort). Project 1:
“Synthesis of Novel Analogs”, $678,091 direct costs, 7/1/08-6/30/13 (P.I. Peter A. Crooks, 15%
effort). Project 2: “Nicotinic Receptor Subtype Selectivity”, $2,115,330, direct costs, 7/1/086/30/13 (P.I. Linda P. Dwoskin, Co P.I. Peter A. Crooks, 5% effort), priority score 184.
“Development of Novel Treatments for Nicotine Addiction”, NIH-NIDA (U19; DA017548),
National Coorperative Drug Discovery Groups (NCDDG-MD/NA), $8,823,739, 7/1/08-6/30/13,
(Program Director: Linda P. Dwoskin; P.I.s Linda P. Dwoskin, Peter A. Crooks (30% effort),
Michael T. Bardo). Scientific Core: “Scale-up, Pharmacophore Modeling, Pharmacokinetics and
Metabolism”, $861,409 direct costs, 7/1/08-6/30/13 (P.I. Peter A. Crooks, 10% effort). Project 1:
“Synthesis of Novel Analogs”, $678,091 direct costs, 7/1/08-6/30/13 (P.I. Peter A. Crooks, 15%
effort). Project 2: “Nicotinic Receptor Subtype Selectivity”, $2,401,422, direct costs, 7/1/086/30/13 (P.I. Linda P. Dwoskin, Co P.I. Peter A. Crooks, 5% effort), pending.
“Nornicotine as a Treatment for Nicotine Abuse”, STTR Phase 2 (3rd year)/NIH/NIDA; $150,000,
6/1/08-12/31/08. (P.I. Peter A. Crooks, 15% effort), funded.
“Exploiting Stress Response Pathways for Strategies to Improve Radiation Therapy” PPG
NIH/NCI, competitive renewal, 7/01/09-6/30/14, (Program Director, Joseph Roti Roti),
$7,852,708 total direct costs; Core D, $498,386 total direct costs, $241,717 total indirect costs
(P.I. Peter A. Crooks, 10% effort), pending.
171
“Development of Small Molecule Radiation Sensitizers”. R01/NIH/NCI, 8/01/09-7/30/14, (P.I.
Michael L. Freeman), $1,680,124 total direct costs, $570,467 total indirect costs; subcontract
$430,190 total direct costs, $208,641 total indirect costs (P.I. Peter A. Crooks, 10% effort)
pending, priority score 195.
“Development of Small Molecule Radiation Sensitizers”. R01/NIH/NCI, 12/01/09-11/30/14, (P.I.
Michael L. Freeman), $2,250,592 total direct costs, $638,831 total indirect costs; subcontract
$430,190 total direct costs, $208,641 total indirect costs (P.I. Peter A. Crooks, 10% effort)
pending (resubmission), 1st percentile, funded.
“Lidocaine-Ketoprofen Combination Gel for the Treatment of Pain Associated with
Osteoarthritis”. KSEF Research and Development Excellence Program. Emerging Technologies,
7/01/09-6/31/11, $60,000 total direct costs (P.I. Peter A. Crooks, 2% effort), pending.
“Development of Novel Treatments for Nicotine Addiction”, NIH-NIDA (U19; DA017548),
National Coorperative Drug Discovery Groups (NCDDG-MD/NA), $7,850,685, 12/1/09-11/30/14,
(Program Director: Linda P. Dwoskin; P.I.s Linda P. Dwoskin, Peter A. Crooks (30% effort),
Michael T. Bardo). Scientific Core: “Scale-up, Pharmacophore Modeling, Pharmacokinetics and
Metabolism”, $1,090,217 direct costs, 12/1/09-11/30/14 (P.I. Peter A. Crooks, 10% effort).
Project 1: “Synthesis of Novel Analogs”, $663,323 direct costs, 12/1/09-11/30/14 (P.I. Peter A.
Crooks, 15% effort), pending.
“Accurate Mass Q-TOF LC/MS for the University of Kentucky Mass Spectrometer Facility
(UKMSF)”; NIH-S10 Shared Instrumention Grant Program, $499,315.02, 12/01/09. (P.I. Bert
Lynn, Co P.I. Peter A. Crooks), pending.
“Identification of Selective Antagonists for 910 Nicotinic Receptors”, NNIH-NIDA (Challenge
Grant, RFA-OD-09-003; CFDA No. 93.701), $989,988, total direct $795,793,000, 12/1/0911/30/11, (P.I. Peter A. Crooks, 15% effort), pending.
“Development of Novel Therapies for Methamphetamine Abuse”, NIH/NIDA Supplemental Grant
Program, $383,682.16, total direct $719,103.35, total direct and indirect $1,036,831.80,
12/01/09-11/30/11 (P.I. Linda Dwoskin, Co P.I. Peter A. Crooks, 10% effort), funded.
“Novel 910 Nicotinic Receptor Antagonists for Pain Management”. NIH/NIDA R21 Application,
$316,334 total direct costs, $153,422 total indirect costs (P.I. Joseph R. Holtman; Peter A.
Crooks, CoP.I.), 6/1/10-5/31/12 (2.5% effort), pending.
“Kentucky Center for Clinical and Translational Science”, National Institutes of Health, CTSA
Application, $19,999,381, total direct costs, 1/1/10-6/30/15, P.I. Philip A. Kern, Co P.I. Peter A.
Crooks), pending.
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