Name in full (in block letters) : JAVID HUSSAIN ZAIDI
Father’s name : KARRAR HUSSAIN ZAIDI
Date of Birth: 05-12-1950
Mailing address: Department of Chemistry Quaid-I-Azam University,
Islamabad
Present occupation: Associate Professor
Nationality: Pakistani
Email: javid_zaidi@qau.edu.pk
Name of Institution
Subjects
Dates attended
University of Birmingham 1977-80
UK
Quaid-i-Azam University 1971-72
ChemistryIslamabad
University of the Punjab, 1968-70
Lahore
University of the Punjab, 1966-68
Lahore
Degree
Ph .
D. Chemistry
M.Phil Organic
M.Sc Chemistry
B.Sc. Chemistry & Physics
1) Post Doctoral Research Fellow, 1 st
. July to 30 th
September1983, Department of
Chemistry, University of Birmingham UK.
Topic of Research : Synthesis of 4-acyl substituted dienones.
Supervisor : Dr. A.J.Waring
2) Post Doctoral Research Fellow, January 1988 to April 1989, Department of
Chemistry, University of Hawaii, USA;
Topic of research: Total synthesis of vineomycinone B
2
Supervisor: Professor M.A.Tius
3) Post Doctoral Research Fellow, September 1991 to August 1992, Mayo Clinic,
Jacksonville, Florida, USA ;
Topic of Research: Synthesis of mimics of neurotensin and IL-I-

Protease inhibitor, drug designing for Alzheimer’s disease and cancer Chemotherapy.;

Supervisor: Prof. A.P. Kozikowski.
4) Post Doctoral Research Fellow, September 1994 to August 1995, Mayo Clinic,
Jacksonville, Florida, USA.
Topic of Research: Synthesis of mimics of neurotensin
Supervisor: Prof. E. Richelson.
5) Post Doctoral Research Fellow, September 2001-August 2002, Department of
Chemistry, University of Hawaii, USA;
Topic of Research: Synthesis of inhibitor of dopamine receptor.
Supervisor: Professor M.A.Tius
1a: PhD’s Produced*: (Extra pages may be added if required) Total Number: 03
S.No
Student’s Name
Thesis title
1 Fazal Naeem Synthesis and Bioassay of Neurotensin Mimetics and Anthraquinones, Methodology for the
Synthesis of Chiral Dithioacetals
Year
2005
2 Iftikhar Ahmad Synthesis, Characterization ,Blocking and deblocking of Isocyanates.
2009
3 Mohammad
Arfan
Synthesis and Biological Evaluation of
Hexapeptdie Analog of NeurotensinNT (8-13)
1.b. PhD students currently under supervision: Total Number: 03
* A student recommended for the award of degree by the Advanced Studies and Research Board.
S.No
Student’s Name Thesis title
1 Hidayat Ullah Synthesis ,characterization ,catalytic and Biological evaluation of β-Peptides
2011
Year
2
3
Sher Wali Khan Synthesis of chiral Compounds of Biological and synthetic Interest, Using anhydride of L-tartaric
Tahir Mehmood acid.
2a: M.Phil. Produced: (Extra pages may be added if required) Total Number: 12
S.No
Student’s Name
Thesis title
1 Saima Kanwal Synthesis of N-methoxymethyl tertiary amines and
Their Reactions
2
Year
2004
Reactions of Diacetyl L- Tartaric acid anhydraide 2005
3
Syed Jabbar
Hussain Shah
Sadullah Mir Synthesis of Benzyl chloromethyl ether insitu for the Protection of Bifunctional Hydroxyl
2006

4
5
6
7
8
Compounds
Sher Wali Khan Mannich Reactions of Phenols and Polyphenolic
Compounds and Biological Studies of the Products
Asymmetric Induction Through Metalation of Naseem Iqbal
Gunjial
Sarwat Tahira
Chiral Dithioacetals and Oxathioacetals
Reactions of Benzyloxymethyl Protected Phenol and Synthesis of Benzyloxymethyl N-Protected L-
Amino acids
Tahir Mehmood Reaction of Diacetyl-L-Tartaric Acid Anhydride
Sara Naz Synthesis and Biological Evaluation of Chiral
Imides of Diacetyl-L- Tartaric Acid.
9 Azhar Hussain
Shah
10 Aqeel Hussain
11
12
Nazish Ishtiaq
Auje Sana
Synthesis Characterization and Biological
Evaluation of β-Peptides
Synthesis and characterization of γ-Amino acids starting from α-Amino acids.
Synthesis of protected Half-Ester of L-Tartaric acid and its reaction with α Amino acids and phenols.
Alkylation of chiral menthol esters of succinic acid via metallation.
2.b. M. Phil. students currently under supervision: Total Number: 04
Project Title
Synthesis and Biological Evaluation of Hexapeptdies Analog of
NeurotensinNT (8-13)
The Synthesis of Chiral Compounds of biological and Synthetic Interest,
Using Anhydride of L-Tartaric Acid
Principal /
Co-
Principal
Investigator
Principal Rupees
1 Million
Principal Rupees
3.8 Million
Agency
Pakistan Science
Foundation
Higher
Education
Commission
2006
2006
2007
2007
2007
2008
2009
2010
2011
2 years
3 years
1.
Member American Chemical Society.
2.
Member Mayo Alumini Society.
3.
Member Chemical Society of Pakistan

1) Synthesis of 3,4-dihydro-3, 3,8a-trimethylnaphthalene-1, 6( 2H , 8aH)-dione, a 4- acylcyclohexa 2,5-dienone, Javid H. Zaidi and Anthony J. Waring; J. C. S.
Chem. Comm . (U.K).618, 1980.
2) Dienone-phenol rearrangements of bicyclic cyclohexa-2, 5-diene-1-ones;
Kinetic studies of the importance of a multistage mechanism.Anthony J.
Waring, Javid H. Zaidi and James W. Pilkington.
J. Chem. Soc. Perkin.
Trans. II , (U.K).
935. 1981.
3) Dienone-phenol rearrangements of bicyclic cyclohexa-2, 5-dienones;
Confirmation of a multistage mechanism. Anthony J. Waring, Javid H. Zaidi and James W. Pilkington. J. Chem. Soc. Perkin. Trans. I, (U.K).1454. 1981.
4) Synthesis of a 4-acylcyclohexa-2, 5-dienone: 3,4-Dihydro-3, 3,8a- trimethylnaphthlene-1, 6( 2H , 8aH)-dienone. Anthony John Waring and Javid
H. Zaidi. J. Chem. Soc. Perkins Trans.1, (U.K).
631, 1985.
5) A Bifunctional Anthraquinone Synthon. Marcus A. Tius, Jorge Gomez-
Galeno and Javid H. Zaidi , Tetrahedron Let .(U.K) 52 , 6909 , 1988.
6) C -Glycosylanthraquinone Synthesis: Total Synthesis of Vineomycinone B2
Methyl Ester. Marcus A. Tius, Jorge Gomez-Galeno, Xue-qin Gu and Javid H.
Zaidi . J. Amer. Chem. Soc.
(USA).
113, 5775 . 1991.
7) Pharmacological Studies on Novel Neurotensin Mimetics: Discovery of a
Pharmacologically Unique Agent Exhibiting Concentration-Dependent Dual Effects as Antogonists and Agonist.Bernadette Cusack, Elliott Richelson, Yuan-Ping Pang,
Javid H. Zaidi and Alan P. Kozikowski. Molecular Pharmacology , (USA). 44 , 1036,
1993.
8) Rational Design of Novel Neurotensin Mimetics: Discovery of a
Pharmacologically Unprecedented Agent Exhibiting Concentration-dependent
Dual Effects as Antagonist and Full Agonist. Yuan-Ping Pang, Javid H.
Zaidi , Alan P. Kozikowski, Bernadette Cusackand Elliott Richelson. J.
Computer-Aided Mol. Design, (Netherland).
8, 433, 1994 .
9) Synthesis of Partial Nonpeptidic Mimetics as Potential Neurotensin Agonists and Antagonists.Alan P. Kozikowski, Dharmpal S. Dodd, Javid H. Zaidi ,

Yuan-Ping Pang, Bernadette Cusackand Elliott Richelson
.
J.Chem. Soc.
Perkins Trans.1, (U.K).
1615, 1995.
10) Cholinergic Agents structurally related to furtrethonium.3.Synthesis and Anti muscarinic activity of series of N-(5-methyl-2-furfuryl and –tiophenyl)dialkylamines and of 2-dimethylaminomethyl-4-(1'-substituted-acetoxymethyl)-1,3-dioxolanes.Manferedini S; Guarneri M; Ferroni R; Simoni D;
Javid H. Zaidi ; Grana E and Boselli C. Drug Design and Discovery . 13 ,1-12,
1995.
11) A Convenient Preparation of n -Butyl chloromethyl ether and its Use in otho - directed metalation of Phenols. Javid H. Zaidi . Synth. Comm.
(U.K).26,
2407, 1996.
12) Synthesis of Novel Metabolically Stable Analogues of Dmyo -inositol 1,4,5-
Trisphosphate. Abdul H. Fauq, Javid H. Zaidi , Robert A. Wilcox, Girlie Varvel,
Stefan R. Nahorski, Alan P. Kozikowski and Christophe Erneux
Tetrahedron Let .(U.K).
37, 1917, 1996.
13) Design Synthesis and Pharmacological Evaluation of Active Pyrrol Based,
Nonpeptidic Analogues of Neurotensin (8-13). Feng Hong, Javid H. Zaidi , Yuan-
Ping Pang, Bernadette Cusackand Elliott Richelson . J. Chem. Soc. Perkins Trans.1,
(U.K). 2997, 1997.
14) Comparative Studies of the Deprotection of Various acid Sensitive
Protecting Groups With Pyridinium p -toluenesulphonate. Javid H. Zaidi ,
Abdul H. Fauq, and Naseera Ahmed. Tetrahedron Lett .,(U.K) 39 ,
4137,1998.
15) Synthesis and Bioactivities of Naturally Occurring Anthraquinones:
Isochrysophenol, Isozyganein,

-Hydroxyisochrysophenol and
Moriindaparvin. Javid H. Zaidi , Fazal Naeem, Rashid Iqbal, Mohammed
Iqbal Choudary, Khalid M.Khan, Shahnaz Perveen c
, Syed T. Ali Shah,
Safder Hayat and wolfgang Voelter. Z. Naturforsch.
(Germany) 56b, 689-
696, 2001 .
16) Synthesis and Biological Stydies of Novel Neurotensin (8-13) Mimetics,
Feng Hong, Javid H. Zaidi , Bernadette Cusack and Elliot Richelson.

Bioorganic & Medicinal Chemistry (USA). 10, 3849-3858, 2002 .
17) Synthesis of Dithioacetals and Oxathioacetals with Chiral Auxiliaries
Javid H. Zaidi , Fazal Naeem, Khalid M. Khan, Rashid Iqbal and Zai-Ullah.
Synthetic Communications (U.K). 34 , 2641.
2004 .
18) An Expeditious Approach Towards Synthesis of Oxathioacetals and
Dithioacetals, Javid H. Zaidi , F. Naeem, K.M. Khan, R. Iqbal, Zia-Ullah and S. Perveen, Jour.Chem Soc. Pak ., (Pakistan). 26, (3), 333-339, 2004.
19) Reactions of N-Protected Amino Acids with Alkoxy chloromethyl ethers and
Chloromethyl Sulfide. Javid H. Zaidi , M. Arfan , Khalid M. Khan, Shahnaz
Perveen and Nida Ambereen
,
Letters in Org. Chem. ( United Arab Emirates) 3,
242-243. 2006 .
20) Synthesis, Anti- microbial and Anti-HIV Activity of Some Novel Benzene
sulfonamides Bearing 2, 5- Disubstituted-1,3,4- Oxadiazole Moiety,
R. Iqbal
*
, M. Zareef, S. Ahmed, J. H. Zaidi , M. Arfan, M. Shafique
and N.A. Al- Masoudi. J. Chinese. Chem. Soc.
(China).
53, (3), 2006 .
21) N-{[-(5-(Benzylsulfanyl)-1,3,4-oxadizol-2-yl]-ethyl}-4-chlorobenzene sulfonamide. M. Zareef, Rashid Iqbal, Masood Pervaz, Javid.H. Zaidi and M.
Arfan
,
Acta.Cysrtalographica Section E.
o2449-o2451 2006.
22) 4-Methyl-N-[1-(5-(thioxo-4,5-dihydro-1,3,4-oxadizol-2-yl)propyl]Benzene-
sulfonamide. M. Zareef, Rashid Iqbal, Masood Pervaz, Javid. H. Zaidi and
M.Arfan. Acta.Cysrtalographica Section E.
(Denmark).o2481-o2483 2006.
23) N- BenzoylN` -methylN ` (p-tolylsulfony) hydrazine. Muhammad Zareef, Rashid
Iqbal, Masood Pervaz, Javid. H. Zaidi and Muhammad Arfan .
Acta.Cysrtalographica Section E.
(Denmark).o3049-03051,2006.
24) 1- [(4- Methylphenyl)sulfonyl]pyrrolidin-2-one. M .Zareef, Rashid Iqbal,
Masood Pervaz, Javid. H. Zaidi and Muhammad Arfan. Acta.
Cysrtalographica
Section E. (Denmark).o2955-o2957 2006.
25) A Convenient Synthesis and Antibacterial Activities of Symmetrical and
Asymmetrical 2,5-Disubsituted 1, 3, 4-Oxadiazoles. R. Iqbal
*
, S. Ahmed, J. H.
Zaidi , M. Zareef, M. Arfan and S. A.Shahzad, Jour.Chem Soc. Pak., (Pakistan).
28, (2), 165-168 2006.

26) Pyrrole-Based Partial Peptidic Mimic of Neurotensin (8-13): Design and
Synthesis, Javid H. Zaidi , Fazal Naeem, Nida Ambreen, Khalid M. Khan,
Yuan-Ping Pang, Bernadette Cusack, Elliot Richelson, Awais Anwar and
Wolfgang Voelter, Letters in Org. Chem. ( United Arab Emirates) 3, 21-24.
2006 .
27) Crystal structure of Picolinic acid hydrazide, C
6
H
7
N
3
O. M. Zareef, R.
Iqbal, J. H. Zaidi , G. Qadeer, W. Y. Wong and H. Akhtar, Z.
Kristallogr. NCS 221 , 2006.
28) Carbonic anhydrase inhibitors. Inhibition of human tumer-associated
isozymes IX and cytosolic isozymes I and II with some 1,3,4
oxadiazole-thiols Muhammad Zareef, Alessio Innocent, Rashid Iqbal, ,
Javid.H. Zaidi , Muhammad Arfan, Andrea Scozzafava, & Claudiu Supuran.
Enzyme Inhibitionand and Medicinal Chem. 21(4).315-359, 2006.
29) Synthesis, Anti- microbial and Anti-HIV Activity of Some Novel
Benzenesulfonamides Bearing 2, 5- Disubstituted-1,3,4- Oxadiazole Moiety,
M. Zareef, R. Iqbal, S. Ahmed, J. H. Zaidi , M. Arfan, and N.A. Al-
Masoudi. Phosphorus, Sulphur, and Silicon,182:281-298, 2007 .
30) Synthesis, Characterization and thermal dissociation of 2-butoxyethanol- blocked diisocynates and their use in the synthesis of isocynate- terminated prepolymers. Iftikhar Ahmed, Javid H Zaidi , Rizwan Hussain and Arshad
Munir, Polym Int, 56, 1521-1529, 2007.
31) Microwave-Assisted Synthesis and Anti-HIV activity of new
Benzenesulphunamides bearing 2,5- Disubstituted- 1,3,4- oxadiazole
Moiety. M. Zareef, Rashid Iqbal, Najim A. Al-Masuodi, Javid H. Zaidi and M. Arfan.
Heteroatom Chemistry , 18, 4, 2007.
32) Phenyl 3-phenyloxiran-2-yl ketone, J. H. Zaidi , Tahir Mehmood, M.
Zareef, G. Qadeer and W. Y. Wong. Acta.Cysrt E63, o1721-1722 2007.
33) Asymmetric Induction through Metalation of Chiral Dithioacetals and
Oxathioacetals. Javid H. Zaidi and Naseem Iqbal Gunjial, Synthetic
Communications 37 ,17, 2835-2845.
2007 .
34) Synthesis and antimalarial activity of novel chiral and achiral

Benzenesulfonamides bearing 1,3,4-oxadiazole moieties. M. Zareef,
Rashid Iqbal, Neira Gamboa De Dominguez, Juan Rodrigues, Javid H.
Zaidi , M, Arfan and Claudiu T. Supuran. Enzyme Inhibition and
Medicinal Chemistry. 22(3), 301-308, 2007.
35) In Situ synthesis of Benzyl chloromethyl ether and its use for the protection
and deprotection of bifunctional hydroxyl compounds. Javid H, Zaidi,
Khalid M, Khan, Saadullah Mir, Naseem Iqbal Gunjial and M. Arfan.
Letters in Organic Chmemistry , 5, 125-127, 2008.
36) An improved method of synthesis of N-protected L-amino acids as their
Benzoxymethyl esters. Javid H, Zaidi , M. Arfan, Saadullah Mir, Jabbar H.
Shah, Shahnaz Perveen and Khalid M. Khan.
Natural Product Research, 22
No1, 22-25, 2008.
37) Proline-β-Amino-Ester Dipeptides as efficient catalysts for Enantioselective
Direct Aldol Reaction in Aqueous medium.Mauro De Nisco, Silvana pedatella,
Hidayatullah, Javid. H.Zaidi
, Daniele Naviglio Ozgur ozdamar Romauldo caputo. J.Org.Chem.2009, 74, 9562-9565.
38)Synthesis of Imides and Amides from Diacetyl-L-Tartaric Acid Anhydride Sara Naz,
J.H. Zaidi, Tahir Mehmood, Sher Wali, Muhammad Ali, Muhammad Taha and
Khalid M. Khan. letters in organic chemistry,vol.7,2010,319-322

Project Title
Synthesis and Biological Evaluation of Hexapeptdies Analog of
NeurotensinNT (8-13)
The Synthesis of Chiral Compounds of biological and Synthetic Interest,
Using Anhydride of L-Tartaric Acid
Principal /
Co-
Principal
Investigator
Principal Rupees
1 Million
Principal Rupees
3.8 Million
Agency
Pakistan Science
Foundation
Higher
Education
Commission
2 years
3 years