How to create an Amendment via TierBase
Creating an amendment to an AEC protocol via TierBase can be used for a number of
different functions. These include;
 Answering conditional revisions
 Applying for a minor change
 Applying for a modification
Please find listed below directions for creating an amendment via TierBase, and also the
submission requirements.
How to create an amendment
Step 1: Log onto TierBase
Step 2: Click on ‘List my AEC protocols’
Step 3: Select the protocol you wish to create an amendment and click ‘Modify Selected’
Step 4: Select ‘Create Project Amendment’
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Step 5: Click ‘Create amendment for AEC xxx/0x’
Step 6: Click ‘Duplicate AEC xxx/0x’
Step 7: Click ‘OK’. A duplicate copy of the original protocol has now been created.
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Step 8: Please complete the ‘Ethics Amendment’ form to justify your amendment and
also details any animal welfare issues introduced by this amendment.
 Conditional Revisions: Please include details of the revisions required by the
committee in the justification section.
 Minor Change: Please indicate that you are applying for a minor change in the
justification section. Please outline what the change is, i.e. swapping one strain of
animals for another without increasing the total number of animals required, and
why it is required.
 Modification: Please indicate you are applying for a modification in the
justification section. Please give a small report on the progress of the protocol so
far, including the number of animals approved and the number used. Please
outline what the modification is and why it is required.
Step 9: Click ‘Save Amendment’. This will take you back to your listed AEC protocols.
Step 10: Return to the TierBase main screen.
Step 11: Click on ‘List my AEC protocols’
Step 12: You will now see 2 copies of your selected AEC protocol. Click on the copy
listed as ‘Revision 1’ and ‘Amendment’. This is an unlocked copy of the original
protocol, which can be modified.
Step 13: Select the protocol you wish to modify and click ‘Modify Selected’
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Step 14: After you have created all of the necessary changes to the revised protocol (and
SAVED it), click ‘Show Project Amendments’.
Step 15: Click ‘Print Amendment’.
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Step 16: Click ‘Yes-Print Summary’. This prints a summary document that outlines the
changes between the original protocol and the revised one.
Step 17 (Only required for Conditional Revisions and Modifications): Click ‘Yes –
Print Application’. This will print of a copy of the revised protocol.
Submission Instructions:
Conditional Revisions:
 Summary of Changes: 1 hard copy (single sided)
 Revised Protocol: 2 hard copies (single sided)
Minor Change:
 Summary of Changes: 3 hard copies (single sided)
Modification:
 Summary of Changes: 16 hard copies (single sided)
 Revised Protocol: 2 hard copies (single sided)
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