Dear Annabel Phillip Senior Assistant Editor, Thanks for E-mail and review the article. This is the modifications regarding devoted editorial concerns point-by-point as follow: (A): Addressing the valuable comments of the reviewer: MAJOR COMPULSORY REVISION: 1/ Test kid and LAB methodology for tests in the method section stated. 2/ Yes. Angina and MI inventory of London Health School along with taking medical history and clinical examination for evaluating subjects were performed. And Healthy subject recruited into the study. 3/ Descriptive analysis approach were used for analyzing the data. Frequency tables for categorical data and calculation of Mean and SD for quantitative variables were performed. 4/ regarding table 1- and other results this burden of risk factors are related to increase hazard of coronary artery disease . however , the endpoint of CAD in this population after a reasonable period of time (latency period about 10 years) will demonstrate the real pattern of CAD incidence. The result of a nested case control design for evaluation OF THIS relation is going to publish in the other article . Uufortunately , present situation of CAD disease in IRAN is less known and the research in this area is very primitive ,so for situation analysis we need this information . 5/ studies from ASIA and ARABIC countries included in the introduction and discussion and addressed in the reference number 6/ prevalence of risk factors in the conclusion section addressed , again. MINOR ESSENTIAL REVISION: 1/ the text edited by an English language professional . I hope the language is going to be utilized , adequately . 2/ revision of references addressed. 3/ Abbreviation of the parameters on below the tables listed. 4/ Standard deviation in the tables showed with preceding +/-. (B): 1- for improving the written English ,copy-edition of the whole paper by an English language professional were addressed. 2- Medical faculty ethical committee approved the study protocol. 3- Competing interests section were included . all the laboratory funds provided by myself. 4- HATMI ZN, proposing the idea , designing the study, analyzing the data ,preparing the manuscript and monitoring the whole process from designing to preparing the manuscript. TAHVILDARI S applying the health questionnaire and collection of the data .GAFARZADEH A carried out the data collection (taking history and clinical examination, SABOURI A editing the prepared manuscript. Lab Staff getting money for the LAB tests . With The Best Regards Dr Hatmi