Supplementary Appendix A: list of trials examined
PMID
Author
19767093 Ciuleanu T
Year
2009
Journal
Lancet Oncol
Title
Maintenance pemetrexed plus best supportive
care vs placebo plus best supportive care for
non-small-cell lung cancer: a randomised,
double-blind, phase 3 study.
19075278 Fidias PM
2009
J Clin Oncol
Phase III study of immediate compared with
delayed docetaxel after front-line therapy
with gemcitabine plus carboplatin in advanced
non-small-cell lung cancer.
19692680 Mok TS
2009
N Engl J Med
Gefitinib or carboplatin-paclitaxel in
pulmonary adenocarcinoma.
19410716 Pirker R
2009
Lancet
Cetuximab plus chemotherapy in patients with
advanced non-small-cell lung cancer (FLEX): an
open-label randomised phase III trial.
19188680 Reck M
2009
J Clin Oncol
Phase III trial of cisplatin plus gemcitabine
with either placebo or bevacizumab as firstline therapy for nonsquamous non-small-cell
lung cancer: AVAil.
19027483 Kim ES
2008
Lancet
Gefitinib versus docetaxel in previously
treated non-small-cell lung cancer (INTEREST):
a randomised phase III trial.
18520802 Langer CJ
2008
J Thorac Oncol
Phase III trial comparing paclitaxel poliglumex
(CT-2103, PPX) in combination with
carboplatin versus standard paclitaxel and
carboplatin in the treatment of PS 2 patients
with chemotherapy-naïve advanced non-small
cell lung cancer.
18594318 O'Brien ME
2008
J Thorac Oncol
Randomized phase III trial comparing singleagent paclitaxel Poliglumex (CT-2103, PPX)
with single-agent gemcitabine or vinorelbine
for the treatment of PS 2 patients with
chemotherapy-naïve advanced non-small cell
lung cancer.
18506025 Scagliotti G
2008
J Clin Oncol
Phase III study comparing cisplatin plus
gemcitabine with cisplatin plus pemetrexed in
chemotherapy-naive patients with advancedstage non-small-cell lung cancer.
17602080 Cobo M
2007
J Clin Oncol
Customizing cisplatin based on quantitative
excision repair cross-complementing 1 mRNA
expression: a phase III trial in non-small-cell
lung cancer.
17442998 Gatzemeier U
2007
J Clin Oncol
Phase III study of erlotinib in combination with
cisplatin and gemcitabine in advanced nonsmall-cell lung cancer: the Tarceva Lung
Cancer Investigation Trial.
17079694 Ohe Y
2007
Ann Oncol
Randomized phase III study of cisplatin plus
irinotecan versus carboplatin plus paclitaxel,
cisplatin plus gemcitabine, and cisplatin plus
vinorelbine for advanced non-small-cell lung
cancer: Four-Arm Cooperative Study in Japan.
18024869 Park JO
2007
J Clin Oncol
Phase III trial of two versus four additional
cycles in patients who are nonprogressive
after two cycles of platinum-based
chemotherapy in non small-cell lung cancer.
16569462 Brodowicz T
2006
Lung Cancer
Cisplatin and gemcitabine first-line
chemotherapy followed by maintenance
gemcitabine or best supportive care in
advanced non-small cell lung cancer: a phase
III trial.
16371411 Camps C
2006
Ann Oncol
Randomized phase III study of 3-weekly versus
weekly docetaxel in pretreated advanced nonsmall-cell lung cancer: a Spanish Lung Cancer
Group trial.
16446341 Paccagnella A
2006
J Clin Oncol
Adding gemcitabine to paclitaxel/carboplatin
combination increases survival in advanced
non-small-cell lung cancer: results of a phase
II-III study.
16549837 Pas-Ares L
2006
J Clin Oncol
Phase III study of gemcitabine and cisplatin
with or without aprinocarsen, a protein kinase
C-alpha antisense oligonucleotide, in patients
with advanced-stage non-small-cell lung
cancer.
16682727 Ramlau R
2006
J Clin Oncol
Phase III study comparing oral topotecan to
intravenous docetaxel in patients with
pretreated advanced non-small-cell lung
cancer.
17047644 Von Plessen C
2006
Br J Cancer
Palliative chemotherapy beyond three courses
conveys no survival or consistent quality-oflife benefits in advanced non-small-cell lung
cancer.
15860487 Belani CP
2005
Ann Oncol
Randomized phase III trial comparing cisplatinetoposide to carboplatin-paclitaxel in
advanced or metastatic non-small cell lung
cancer.
16288485 Belani CP
2005
Cancer
Elderly subgroup analysis of a randomized
phase III study of docetaxel plus platinum
combinations versus vinorelbine plus cisplatin
for first-line treatment of advanced nonsmall
cell lung carcinoma (TAX 326).
15681529 Bissett D
2005
J Clin Oncol
Phase III study of matrix metalloproteinase
inhibitor prinomastat in non-small-cell lung
cancer.
15728228 Georgoulias V
2005
J Clin Oncol
Vinorelbine plus cisplatin versus docetaxel
plus gemcitabine in advanced non-small-cell
lung cancer: a phase III randomized trial.
16043829 Herbst RS
2005
J Clin Oncol
TRIBUTE: a phase III trial of erlotinib
hydrochloride (OSI-774) combined with
carboplatin and paclitaxel chemotherapy in
advanced non-small-cell lung cancer.
15837997 Leighl NB
2005
J Clin Oncol
Randomized phase III study of matrix
metalloproteinase inhibitor BMS-275291 in
combination with paclitaxel and carboplatin in
advanced non-small-cell lung cancer: National
Cancer Institute of Canada-Clinical Trials
Group Study BR.18.
15625373 Lilenbaum RC
2005
J Clin Oncol
Single-agent versus combination
chemotherapy in advanced non-small-cell lung
cancer: the cancer and leukemia group B
(study 9730).
15741225 Pujol JL
2005
Ann Oncol
Gemcitabine-docetaxel versus cisplatinvinorelbine in advanced or metastatic nonsmall-cell lung cancer: a phase III study
addressing the case for cisplatin.
15625369 Rudd RM
2005
J Clin Oncol
Gemcitabine plus carboplatin versus
mitomycin, ifosfamide, and cisplatin in
patients with stage IIIB or IV non-small-cell
lung cancer: a phase III randomized study of
the London Lung Cancer Group.
16293869 Schuette W
2005
J Clin Oncol
Phase III study of second-line chemotherapy
for advanced non-small-cell lung cancer with
weekly compared with 3-weekly docetaxel.
16293868 Sederholm C
2005
J Clin Oncol
Phase III trial of gemcitabine plus carboplatin
versus single-agent gemcitabine in the
treatment of locally advanced or metastatic
non-small-cell lung cancer: the Swedish Lung
Cancer Study Group.
16014882 Shepherd FA
2005
N Engl J Med
Erlotinib in previously treated non-small-cell
lung cancer.
16257339 Thatcher N
2005
Lancet
Gefitinib plus best supportive care in
previously treated patients with refractory
advanced non-small-cell lung cancer: results
from a randomised, placebo-controlled,
multicentre study (Iressa Survival Evaluation in
Lung Cancer).
16361616 Willamson SK
2005
J Clin Oncol
Phase III trial of paclitaxel plus carboplatin
with or without tirapazamine in advanced
non-small-cell lung cancer: Southwest
Oncology Group Trial S0003.
15266334 Comella P
2004
Br J Cancer
Gemcitabine with either paclitaxel or
vinorelbine vs paclitaxel or gemcitabine alone
for elderly or unfit advanced non-small-cell
lung cancer patients.
15226327 Georgoulias V
2004
J Clin Oncol
Docetaxel versus docetaxel plus cisplatin as
front-line treatment of patients with advanced
non-small-cell lung cancer: a randomized,
multicenter phase III trial.
14990632 Giaccone G
2004
J Clin Oncol
Gefitinib in combination with gemcitabine and
cisplatin in advanced non-small-cell lung
cancer: a phase III trial--INTACT 1.
15558071 Gridelli C
2004
Br J Cancer
A randomised clinical trial of two docetaxel
regimens (weekly vs 3 week) in the secondline treatment of non-small-cell lung cancer.
The DISTAL 01 study.
15117980 Hanna N
2004
J Clin Oncol
Randomized phase III trial of pemetrexed
versus docetaxel in patients with non-smallcell lung cancer previously treated with
chemotherapy.
14990633 Herbst RS
2004
J Clin Oncol
Gefitinib in combination with paclitaxel and
carboplatin in advanced non-small-cell lung
cancer: a phase III trial--INTACT 2.
14722033 Kubota K
2004
J Clin Oncol
Phase III randomized trial of docetaxel plus
cisplatin versus vindesine plus cisplatin in
patients with stage IV non-small-cell lung
cancer: the Japanese Taxotere Lung Cancer
Study Group.
15197195 Laack E
2004
J Clin Oncol
Randomized phase III study of gemcitabine
and vinorelbine versus gemcitabine,
vinorelbine, and cisplatin in the treatment of
advanced non-small-cell lung cancer: from the
German and Swiss Lung Cancer Study Group.
15151947 O'Brien ME
2004
Ann Oncol
SRL172 (killed Mycobacterium vaccae) in
addition to standard chemotherapy improves
quality of life without affecting survival, in
patients with advanced non-small-cell lung
cancer: phase III results.
15205198 Stathopoulos
GP
2004
Ann Oncol
Front-line paclitaxel-vinorelbine versus
paclitaxel-carboplatin in patients with
advanced non-small-cell lung cancer: a
randomized phase III trial.
12947054 Alberola V
2003
J Clin Oncol
Cisplatin plus gemcitabine versus a cisplatinbased triplet versus nonplatinum sequential
doublets in advanced non-small-cell lung
cancer: a Spanish Lung Cancer Group phase III
randomized trial.
12885812 Belani CP
2003
J Clin Oncol
Multicenter, randomized trial for stage IIIB or
IV non-small-cell lung cancer using weekly
paclitaxel and carboplatin followed by
maintenance weekly paclitaxel or observation.
12879472 Danson S
2003
Cancer
Phase III trial of gemcitabine and carboplatin
versus mitomycin, ifosfamide, and cisplatin or
mitomycin, vinblastine, and cisplatin in
patients with advanced nonsmall cell lung
carcinoma.
12837811 Fossella F
2003
J Clin Oncol
Randomized, multinational, phase III study of
docetaxel plus platinum combinations versus
vinorelbine plus cisplatin for advanced nonsmall-cell lung cancer: the TAX 326 study
group.
12598354 Gonzalez G
2003
Ann Oncol
Epidermal growth factor-based cancer vaccine
for non-small-cell lung cancer therapy.
12837810 Gridelli C
2003
J Clin Oncol
Gemcitabine plus vinorelbine compared with
cisplatin plus vinorelbine or cisplatin plus
gemcitabine for advanced non-small-cell lung
cancer: a phase III trial of the Italian GEMVIN
Investigators and the National Cancer Institute
of Canada Clinical Trials Group.
12618501 Gridelli C
2003
J Natl Cancer Inst
Chemotherapy for elderly patients with
advanced non-small-cell lung cancer: the
Multicenter Italian Lung Cancer in the Elderly
Study (MILES) phase III randomized trial.
12569373 Negoro S
2003
Br J Cancer
Randomised phase III trial of irinotecan
combined with cisplatin for advanced nonsmall-cell lung cancer.
14581415 Smit EF
2003
J Clin Oncol
Three-arm randomized study of two cisplatinbased regimens and paclitaxel plus
gemcitabine in advanced non-small-cell lung
cancer: a phase III trial of the European
Organization for Research and Treatment of
Cancer Lung Cancer Group--EORTC 08975.
12928123 Zatloukal P
2003
Lung Cancer
Gemcitabine plus cisplatin vs. gemcitabine
plus carboplatin in stage IIIb and IV non-small
cell lung cancer: a phase III randomized trial.
12057861 Grigorescu AC
2002
Lung Cancer
Gemcitabine (GEM) and carboplatin (CBDCA)
versus cisplatin (CDDP) and vinblastine (VLB)
in advanced non-small-cell lung cancer
(NSCLC) stages III and IV: a phase III
randomised trial.
12202657 Kosmidis PA
2002
J Clin Oncol
Paclitaxel plus carboplatin versus gemcitabine
plus paclitaxel in advanced non-small-cell lung
cancer: a phase III randomized trial.
12377641 Rosell R
2002
Ann Oncol
Phase III randomised trial comparing
paclitaxel/carboplatin with paclitaxel/cisplatin
in patients with advanced non-small-cell lung
cancer: a cooperative multinational trial.
12409326 Scagliotti G
2002
J Clin Oncol
Phase III randomized trial comparing three
platinum-based doublets in advanced nonsmall-cell lung cancer.
11784875 Schiller JH
2002
N Engl J Med
Comparison of four chemotherapy regimens
for advanced non-small-cell lung cancer.
11870177 Socinski MA
2002
J Clin Oncol
Phase III trial comparing a defined duration of
therapy versus continuous therapy followed
by second-line therapy in advanced-stage
IIIB/IV non-small-cell lung cancer.
12453852 Souquet PJ
2002
Ann Oncol
GLOB-1: a prospective randomised clinical
phase III trial comparing vinorelbine-cisplatin
with vinorelbine-ifosfamide-cisplatin in
metastatic non-small-cell lung cancer patients.
11377599 Georgoulias V
2001
Lancet
Platinum-based and non-platinum-based
chemotherapy in advanced non-small-cell lung
cancer: a randomised multicentre trial.
11432888 Kelly K
2001
J Clin Oncol
Randomized phase III trial of paclitaxel plus
carboplatin versus vinorelbine plus cisplatin in
the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology
Group trial.
11230476 Smith IE
2001
J Clin Oncol
Duration of chemotherapy in advanced nonsmall-cell lung cancer: a randomized trial of
three versus six courses of mitomycin,
vinblastine, and cisplatin.
11697832 Vansteenkiste
JF
2001
Ann Oncol
Clinical-benefit response in advanced nonsmall-cell lung cancer: A multicentre
prospective randomised phase III study of
single agent gemcitabine versus cisplatinvindesine.
10675381 Agteresch HJ
2000
J Natl Cancer Inst
Randomized clinical trial of adenosine 5'triphosphate in patients with advanced nonsmall-cell lung cancer.
10735892 Comella P
2000
J Clin Oncol
Randomized trial comparing cisplatin,
gemcitabine, and vinorelbine with either
cisplatin and gemcitabine or cisplatin and
vinorelbine in advanced non-small-cell lung
cancer: interim analysis of a phase III trial of
the Southern Italy Cooperative Oncology
Group.
10856094 Fossella F
2000
J Clin Oncol
Randomized phase III trial of docetaxel versus
vinorelbine or ifosfamide in patients with
advanced non-small-cell lung cancer
previously treated with platinum-containing
chemotherapy regimens. The TAX 320 NonSmall Cell Lung Cancer Study Group.
11013280 Gatzemeier U
2000
J Clin Oncol
Phase III comparative study of high-dose
cisplatin versus a combination of paclitaxel
and cisplatin in patients with advanced nonsmall-cell lung cancer.
10997806 Kosmidis PA
2000
Ann Oncol
Paclitaxel (175 mg/m2) plus carboplatin (6
AUC) versus paclitaxel (225 mg/m2) plus
carboplatin (6 AUC) in advanced non-small-cell
lung cancer (NSCLC): a multicenter
randomized trial. Hellenic Cooperative
Oncology Group (HeCOG).
10880550 Ranson M
2000
J Natl Cancer Inst
Randomized trial of paclitaxel plus supportive
care versus supportive care for patients with
advanced non-small-cell lung cancer.
10699688 Roszkowski K
2000
Lung Cancer
A multicenter, randomized, phase III study of
docetaxel plus best supportive care versus
best supportive care in chemotherapy-naive
patients with metastatic or non-resectable
localized non-small cell lung cancer (NSCLC).
10623702 Sandler A
2000
J Clin Oncol
Phase III trial of gemcitabine plus cisplatin
versus cisplatin alone in patients with locally
advanced or metastatic non-small-cell lung
cancer.
10811675 Shepherd FA
2000
J Clin Oncol
Prospective randomized trial of docetaxel
versus best supportive care in patients with
non-small-cell lung cancer previously treated
with platinum-based chemotherapy.
10715308 von Pawel J
2000
J Clin Oncol
Tirapazamine plus cisplatin versus cisplatin in
advanced non-small-cell lung cancer: A report
of the international CATAPULT I study group.
Cisplatin and Tirapazamine in Subjects with
Advanced Previously Untreated Non-SmallCell Lung Tumors.
10568679 Bokkel Huinink
W
1999
Lung Cancer
Single-agent gemcitabine: an active and better
tolerated alternative to standard cisplatinbased chemotherapy in locally advanced or
metastatic non-small cell lung cancer.
10458212 Cardenal F
1999
J Clin Oncol
Randomized phase III study of gemcitabinecisplatin versus etoposide-cisplatin in the
treatment of locally advanced or metastatic
non-small-cell lung cancer.
10550150 Crino L
1999
J Clin Oncol
Gemcitabine and cisplatin versus mitomycin,
ifosfamide, and cisplatin in advanced nonsmall-cell lung cancer: A randomized phase III
study of the Italian Lung Cancer Project.
9626213
Giaccone G
1998
J Clin Oncol
Randomized study of paclitaxel-cisplatin
versus cisplatin-teniposide in patients with
advanced non-small-cell lung cancer. The
European Organization for Research and
Treatment of Cancer Lung Cancer Cooperative
Group.
9849452
Helsing M
1998
Eur J Cancer
Quality of life and survival in patients with
advanced non-small cell lung cancer receiving
supportive care plus chemotherapy with
carboplatin and etoposide or supportive care
only. A multicentre randomised phase III trial.
Joint Lung Cancer Study Group.
9552042
Sculier JP
1998
J Clin Oncol
Phase III randomized trial comparing cisplatin
and carboplatin with or without ifosfamide in
patients with advanced non-small-cell lung
cancer. European Lung Cancer Working Party.
9667264
Wozniak AJ
1998
J Clin Oncol
Randomized trial comparing cisplatin with
cisplatin plus vinorelbine in the treatment of
advanced non-small-cell lung cancer: a
Southwest Oncology Group study.
9379341
Lissoni P
1997
J Pineal Res
A randomized study of chemotherapy with
cisplatin plus etoposide versus
chemoendocrine therapy with cisplatin,
etoposide and the pineal hormone melatonin
as a first-line treatment of advanced non-small
cell lung cancer patients in a poor clinical
state.
8874339
Crawford J
1996
J Clin Oncol
Randomized trial of vinorelbine compared
with fluorouracil plus leucovorin in patients
with stage IV non-small-cell lung cancer.
7619749
Crino L
1995
Ann Oncol
Chemotherapy of advanced non-small-cell
lung cancer: a comparison of three active
regimens. A randomized trial of the Italian
Oncology Group for Clinical Research
(G.O.I.R.C.).
8172790
Depierre A
1994
Ann Oncol
Vinorelbine versus vinorelbine plus cisplatin in
advanced non-small cell lung cancer: a
randomized trial.
8201372
Kosty MP
1994
J Clin Oncol
Cisplatin, vinblastine, and hydrazine sulfate in
advanced, non-small-cell lung cancer: a
randomized placebo-controlled, double-blind
phase III study of the Cancer and Leukemia
Group B.
8113844
Le Chevalier T
1994
J Clin Oncol
Randomized study of vinorelbine and cisplatin
versus vindesine and cisplatin versus
vinorelbine alone in advanced non-small-cell
lung cancer: results of a European multicenter
trial including 612 patients.
7900237
Lissoni P
1994
Tumori
A randomized study of immunotherapy with
low-dose subcutaneous interleukin-2 plus
melatonin vs chemotherapy with cisplatin and
etoposide as first-line therapy for advanced
non-small cell lung cancer.
8387607
Cartei G
1993
J Natl Cancer Inst
Cisplatin-cyclophosphamide-mitomycin
combination chemotherapy with supportive
care versus supportive care alone for
treatment of metastatic non-small-cell lung
cancer.
8387576
Gandara DR
1993
J Clin Oncol
Evaluation of cisplatin intensity in metastatic
non-small-cell lung cancer: a phase III study of
the Southwest Oncology Group.
1647183
Shinkai T
1991
Eur J Cancer
A randomised clinical trial of vindesine plus
cisplatin versus mitomycin plus vindesine and
cisplatin in advanced non-small cell lung
cancer.
1646292
Weick JK
1991
J Clin Oncol
A randomized trial of five cisplatin-containing
treatments in patients with metastatic nonsmall-cell lung cancer: a Southwest Oncology
Group study.
2157554
Crino L
1990
Cancer
Chemother
Pharmacol
A randomized trial fo three cisplatincontaining regimens in advanced non-smallcell lung cancer (NSCLC): a study of the
Umbrian Lung Cancer Group.
2167953
Klatersky J
1990
J Clin Oncol
A randomized study comparing cisplatin or
carboplatin with etoposide in patients with
advanced non-small-cell lung cancer:
European Organization for Research and
Treatment of Cancer Protocol 07861.
2156597
Rosell R
1990
Cancer
A randomized study of two vindesine plus
cisplatin-containing regimens with the
addition of mitomycin C or ifosfamide in
patients with advanced non-small cell lung
cancer.
2162239
Rosso R
1990
Cancer
Etoposide versus etoposide plus high-dose
cisplatin in the management of advanced nonsmall cell lung cancer. Results of a prospective
randomized FONICAP trial.
1691921
Woods RL
1990
Br J Cancer
A randomised trial of cisplatin and vindesine
versus supportive care only in advanced nonsmall cell lung cancer.
2833577
Rapp E
1988
J Clin Oncol
Chemotherapy can prolong survival in patients
with advanced non-small-cell lung cancer-report of a Canadian multicenter randomized
trial.
3023556
Klastersky J
1986
J Clin Oncol
A randomized study comparing a high and a
standard dose of cisplatin in combination with
etoposide in the treatment of advanced nonsmall-cell lung carcinoma.
2992785
Shinkai T
1985
Cancer Treat Rep
Comparison of vindesine plus cisplatin or
vindesine plus mitomycin in the treatment of
advanced non-small cell lung cancer.
MeSH Search Terms: “advanced”, “carcinoma, non-small cell lung” and “clinical trial, phase
III” using the clinical queries therapy/narrow search tool.
Professional Oncology Society Guidelines searched: American Society of Clinical Oncology,
European Society of Medical Oncology, Cancer Care Ontario