BME 551
Introduction to Bio-MEMS and Bio-nanotechnology
Instructor:
T. K. Hsiai, M.D., Ph.D. FACC
Robert G. and Mary G. Early Career Chair
Department of Biomedical Engineering and Division of Cardiovascular Medicine
Viterbi School of Medicine and Keck School Medicine
University of Southern California
Office: DRB 172
Tel: 213-740-7236
e-mail: Hsiai@usc.edu
Textbook:
1) Nanotechnology: Basic Science and Emerging Technologies by Mick Wilson,
Kamali Kannangara, Geoff Smith, Michelle Simmons, and Burkhard Raguse
2) The Machinery of Life by David S. Goodsell
Reference:
Microfabrication by Marc Madou
Evaluation:
1) Group journal presentation (3 students per group): 10%
2) Homework X 4: 10 %
3) Midterms X 3: 45%
4) Group project: 35% (20% oral and 15% report)
Jan 10
Introduction: Biomedical Applications and Microfluidics
-Goodsell: Chp 1, 2
-Wilson: Chp 1
-MEMS Shear Stress Sensors for Low Reynolds Number Flow,
Annals of Biomedical Engineering, 2005
Jan 17
Cell and Nanowire Sensors
-Goodsell: Chp. 3
-Wilson” Chp 4, 8
-Group Presentation #1: MEMS sensors (10 minutes)
-HW # 1 due
-Lieber, Silicon nanowire sensors, Science, 1998
Jan 24
Vascular Sensors: Bulk Micromachining and Surface
Chemistry
-Goodsell: Chp 4
-Wilson: Chp 6
-How to Walk on Water, Nature/volume 424/7 August 2003, p 621
-Group Presentation #2: Silicon nanowire sensors (10 minutes)
Jan 31
Sensors for Biodefense: Anthrax
-Goodsell: Chp 5
-Madou: Microfabrication
Midterm #1 (90 min)
1
Feb 7
Surface Micromachining for Biocompatibility
-Goodsell: Chp 6
-Wilson: Chp 9
-Group Presentation #3: How to Walk on Water (10 minutes)
- Lee et al, Integrated Microfluidics, Science, Vol 310, 12/16/2005,
pp 1793-1796
Feb 14
Surface Micromachining and Tissue Culture
Goodsell: Chp 7
Wilson: Chp 6
HW # 2 due
Group presentation #4: Integrated Microfluidics
Nano Sensors for oxidized LDL (Sensors & Actuators, 2005)
Feb 21
Nano and MEMS Devices: Translational Research
Goodsell: Chp 8
Wilson: Chp 2
Group presentation #5: Nano Sensors for oxidized LDL
Crossing the Bilayer: Protein Translocation Across Biological
Membranes, Science, Vol 310, 2005
Feb 28
Biotechnology: Cloning and Plasmid Transfection
Goodsell: Chp 9
Midterm # 2
The Ins and Outs of DNA Transfer in Bacteria, Science, Vol 310,
2005
Mar 7
Bionanotechnology: Quantum Dots
-Group presentation # 6: The Ins and Outs of DNA Transfer in
Bacteria
-HW #3 due
-Design Considerations for Silicon Sensors for Use in Catheters
and Guide Wires, Smart Mater. Struct. II, 2002)
Mar 14
Spring Recess
Mar 21
Design for Living: Nanotechnology for Cancer (Science, 310,
2005)
-Wilson: Chp 7
-Group presentation #7: Design Considerations for Silicon
Sensors for Use in Catheters and Guide Wires
-HW #4 due
Mar 28
Design for Living: Exploring and Engineering the Cell Surface
Interface (Science, 310, 2005)
-Inspiration from Biological Optics for Advanced Photonic
Systems(Science, 310, 2005)
2
April 4
Design for Living: Tissue Cells and Respond to the Stiffness
of Their Substrate (Science, 310, 2005)
-Group presentation #8: Inspiration from Biological Optics for
Advanced Photonic Systems
April 11
-GROUP PROJECT PREPARATION (3 students per group-15
minutes/group)
-Midterm #3
April 18
GROUP PROJECT PRESENTATIONS
3