HOW TO NAVIGATE RESEARCH RESOURCES AT PENN
SYMPOSIUM FOR EARLY INVESTIGATORS
FRIDAY, DECEMBER 11, 2009
SHARED RESOURCES
IAN A. BLAIR, PH.D. (ianblair@mail.med.upenn.edu))
What research cores are available to me and how do I access them?
A. Abramson Cancer Center (ACC)
Center for Cancer Pharmacology (CCP)
Center of Excellence in Environmental Toxicology (CEET)
Institute for Translational Medicine and Therapeutics (ITMAT)
Penn Genome Frontiers Institute (PGFI)
Abramson Cancer Center Proteomics Core:
http://www.penncancer.org/shared_resources.cfm
Shared Resources/Core Facilities
The Cancer Center supports 12 NCI-approved Shared Resources to provide
investigators with easy access to state-of-the-art research technology, equipment, and
technical support that would otherwise be too difficult or expensive for individual
investigat ors or programs to develop. The availability of these core research facilities
significantly increases the ease with which cancer-related research can be conducted on
the campus.
1. Biomedical Imaging Core
Biomedical Informatics Core
Biostatistics Unit
Clinical Cell and Vaccine Production Facility
Clinical Research Unit
DNA Sequencing Facility
Flow Cytometry and Cell Sorting Facility
Histology Service Core
Human Immunology Core
Melanoma Core
Microarray Facility
Molecular Diagnosis & Genotyping Facility
Proteomics Core
Recruitment, Outcomes, and Assessment Resource
Small Animal Imaging Core
Stem Cell and Xenograft Core
Transgenic and Chimeric Mouse Facility
Tumor Tissue Bank
Center for Cancer Pharmacology (CCP) Proteomics Core Facility:
http://www.med.upenn.edu/ccp/proteomonics/index.shtml
Proteomics Core Facility
The mission of the Proteomics Facility is to provide and disseminate state-of-the-art
scientific and technical knowledge in proteomics that will contribute to the research
programs of investigators at the University of Pennsylvania and the Children's Hospital of
Philadelphia.
This will be accomplished by exploiting and evaluating the impacts of discoveries in
proteomics, through focused efforts in:
1. instrumentation
2. protein separation and detection
3. bioinformatics
4.
The Facility is an integral component of the Genomics Institute.
The Proteomics Facility Office
853 BRB II/III
The Proteomics Facility
838 BRB II/III
Philadelphia, PA 19104-6160
215.573.9883 Tel 215.573.9889 Fax
Chao-Xing Yuan, Ph.D. 852 BRB II/III
Christine Busch 838 BRB II/III
Data Processing Room Proteomics Facility 851 BRB II/III
Services provided by the Proteomics Core Facility include:
1. 2D gel electrophoresis
2. Ettan DIGE analysis
3. Applied Biosystems Voyager Pro DE MALDI-TOF mass spectrometer for peptide
mass measurement
4. LCQ Deca XP Plus mass spectrometer for peptide sequencing
Center of Excellence in Environmental Toxicology (CEET):
http://www.med.upenn.edu/ceet/research.shtml#facility_cores
Facility Cores
Molecular Profiling Facility Core
The Molecular Profiling Core (MPC) was formed in April 2008 to provide CEET
investigators with the resources to conduct integrated “omics” and biomarker research
related to toxicant exposure and response. This was accomplished by combining the
resources of the existing Toxicogenomics, Toxicoproteomics, and Biomarker Facility
Cores into a single Facility Core. Each of these individual areas has a dedicated
Technical Director who has considerable expertise in the application of the relevant
technology to toxicology research. The MPC provides an integrated systems biology
approach to identify molecular fingerprints of exposure and response.
Facility Service
Toxicogenomics
Technical Director, Toxicogenomics : Don Baldwin
dbaldwin@mail.med.upenn.edu
Technical Director, Bioinformatics:: John Tobias
jtobias@pcbi.upenn.edu
Request Toxicogenomics Consultation (You must indicate whether you are a CEET
member in your request to gain priority access (dbaldwin@mail.med.upenn.edu )
The mission of the Toxicogenomics component of the Molecular Profiling Core is to
foster both basic and translational research into environmental health science within the
CEET. Existing institutionally supported genomics resources have been expanded to
provide coordinated, focused support for environmental toxicology projects in the CEET.
This is accomplished by providing scientific consultation, instrumentation, and technical
expertise for high throughput RNA transcript profiling, high-throughput genotyping,
massively parallel sequencing, and toxicogenomic data analysis.
Services Available
 Target Preparation and Sequencing
 Massively Parallel Sequencing
 Quantitative PCR
 Custom Multiplex Genotyping
 Whole Genome Profiling
 Transcript Profiling
 DNA Profiling
 Molecular Diagnosis and Genotyping
 Bioinformatics and Data Analysis
 Quality Control for User Projects
Institute for Translational Medicine and Therapeutics (ITMAT):
http://www.itmat.upenn.edu/cores.shtml
Core Facilities
Cores housed within ITMAT are designed to address infrastructural barriers to clinical
and translational research. These cores exist to deliver service and typically have a cost
sharing structure that enables their expansion and development.
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» Automated Claims and Automated Medical Record Databases (ACARD)
» Bioinformatics Facility
» Community Based Research Core (CBRC)
» Community Outreach using Health System Informatics (COHSI)
» Dissemination of Translation (DOT)
» Investigational Drug Service (IDS)
» Kinetics Modeling and Simulation (KMAS)
» Office of Human Subject Advocacy and Protection (OHSAP)
» Outcomes Measurement Methods Core (OMMC)
» Proteomics Core
» Recruitment and Coordination Core (RCC)
» Research Nurse Core (RNC)
» Study Design and Biostatistics (SDAB)
» Translational and Clinical Trial Organization (TACTO)
» Translational Core Lab (TCL)
Penn Genome Frontiers Institute (PGFI):
http://www.genomics.upenn.edu/facilities/core-facilities
Proteomics
The Proteomics Facility, an integral component of the Penn Genome Frontiers Institute,
provides and disseminates state-of-the-art scientific and technical knowledge in
proteomics.
Dr. Ian A. Blair, Scientific Director
ianblair@mail.med.upenn.edu
853 BRB II/III/ Office
838 BRB II/III/ Facility
421 Curie Blvd.
Philadelphia, PA 19104-6160
215-573-9880
215-573-9889 (fax)
Dr. Chao-Xing Yuan, Technical Director
yuancx@mail.med.upenn.edu
215-573-9883
215-573-9889
http://www.med.upenn.edu/ccp/cancer_pharm_bio.shtml