Dispensing of medication 2
PHT 452
T.A. Iman Alfagih
Drugs Reports
PHT 452
1
2
3
4
5
6
7
8
9
10
11
Drug Report Name
Breast cancer
Captopril
Anxiolytic agents
Proton pump inhibitors
acyclovir
Keratolytics
Insulin
Feldene
Metronidazole
Emollients
Ketoconazole
-2 -
with best wishes *** Iman***
DRUG REPORT OUTLINE
===========================
Name and Classification :
Trade Names and Manufactures:
Chemical Structure :
Molecular weight :
Physical Properties :
Pharmacology (Mechanism of Action) :
Pharmacokinetics :
AbsorptionDistribuationProtein bindingMetabolismExcretionLactation**Pregnancy Category:
Therapeutic Uses (Indication) :
Dosage and Administration:
Tolerability (Side Effects):
Contraindication:
Patient Consultations :
Drug Interaction :
A-Drug-Food Interaction:
B-Drug-Drug Interaction:
Dosage Form And Availability :
Storage :
References:
12345-
-3 -
with best wishes *** Iman***
Acne Vulgaris Cream
x
Before "F"
Sulfur (a.I.)
5 gm
Resorcinol (a.I)
2 gm
KOH (emulsifier)
0.74
Stearic acid (emulsifier)
15 gm
Glycerol "Glycerin" (soothing)
20 gm
Methyl paraben (preservative)
0.15 %
Distilled water (vehicle)
q.s. to 100 gm
After "F"
Fiat: yellow cream
Mitte: 25gm
Sig.: MDU

Calculation:
1.
2.
3.
F = 25 / 100 = 0.25
Amount of methyl paraban =
Amount of vehicle "--------------" =

Procedure:
1. In a poracailn dish at the water bath, melt stearic acid until it liquified
2. In a beaker, dissolve well, using a glass rod" Glycerin + water + Methyl paraben
+ KOH" and stir well until clear solution is obtained.
3. Heat the beaker’s content on water bath,
4. Add the warm solution No-3 (aqueous phase)to the porcalin dish’s content (oil
phase), outside the water bath mix well using the pestle for at least 2min, to form
the potassium stearate –emulsifyig agent.
5. In a mortar, powdered the Resorcinol and Sulfur.
6. Add No-4 into No-5, mix well using pestle until homogenous mixture is obtained
7. Continue stirring using the pestle until cold and yellow cream is formed.
8. Transfer to clean close container and fix red label.

Label "red":
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Acne Vulgaris Cream
Direction
Pharmacist:

Date:
Uses:
Treatment of facial and back acne valgaris.
-4 -
with best wishes *** Iman***
Anti-diaper Rash Cream
x
Before "F"
Methyl Paraben (preservative)
0.25 gm
Propyl Paraben (preservative)
0.15 gm
Sodium Lauryl Sulfate (emulsifier)
10 gm
Propylene glycol (demulcant)
120 gm
Stearyl alcohol (oil phase)
250 gm
White petrolatum (oil phase)
250 gm
Purified water (aquaous phase)
370 gm
After "F"
Fiat: White cream
Mitte: 25gm
Sig.: U.D

1.

Calculation:
F = 25 / 1000 = 0.025.
Procedure:
1- In a porcalin dish on the water bath, melt Stearyl alcohol until it turns to a liquid then
add the white petrolatum and wait till it melts completely.
2- In a small beaker, dissolve well using glass rod, the (Methyl Paraben + Propyl
Paraben + Sodium Lauryl Sulfate + Propylene glycol + distilled water) and warm on
water bath. Note: the beaker should reach the same temperature of the porcalin’s
content.
3- Add (Warm Solution) to the mixture in the porcalain dish drop wise, inside the water
bath, to form in situ emulsifier (potassium stearate). Mix well using the pestle for at
least 2 minute. Then remove form water bath.
4- In a mortar, grind the resorcinol and the sulfer to get very fine powder.
5- Then add No-3 into No-4, stirring using the pestle till a white yellow cream is
formed and it’s cold.
6- Transfer to a clean close container and fix red label.

Label "red":
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Antidiaper Rash Cream
Direction
Pharmacist:
Date:
Used as:
1. Antiseptic cream used in diaper rash in Newborn. 2. Emulsifying base.

-5 -
with best wishes *** Iman***
Zinc and Salicylic acid Paste "Lassar's Paste"
x
Before "F"
Zinc oxide (soothing effect)
24 gm
Salicylic acid (peeling effect)
2 gm
Starch (demulcant)
24 gm
White soft paraffin (base)
50 gm
After "F"
Fiat: White base
Mitte: 25gm
Sig.: MDU

Calculation:
1. F = 25 / 100 = 0.25

Procedure:
1. In a mortar, mix well using the pestle zinc oxide with starch then add the salicylic
acid.
2. In a porcailin dish at the water bath, melt the white soft paraffin, till it liquified.
3. Then add No- 2 into No-1; continue stirring till cold and white paste is formed.
4. Transfer to a clean close container and fix red label.

Label "red":
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Pt.’s name
Drug;
Rx #:
Lasser’s Paste
Zinc And Salicylic Acid Paste
Direction
Pharmacist:

Date:
Uses:
1. Act as antiseptic paste for diaper-rash.
2. Protectant.
-6 -
with best wishes *** Iman***
Insect Repellent Lotion
x
Before "F"
Dimethyl Phthalate (a.I.)
750 gm
Magnesium Stearate (antiadherant)
150 gm
Zinc Stearate (soothing &
protective in tx of skin inflamat.)
100 gm
After "F"
Fiat: Lotion.
Mitte: 25gm.
Sig.: M.D.U.

Calculations:
1. F = 25 / 1000 = 0.025

Procedure:
1. In a porcalain dish on the water bath, warm dimethyl phthalate for 1 minute.
2. Then add to it the magnesium stearate on the water bath; stir well for 1 minute, till a
homogenous mixture is formed.
3. then add the zinc stearate and continue stirring to perform the homogenous mixture.
4. Remove from water bath and continue stirring until it’s cold and Ointment is formed.
5. Transfer to a clean close container and fix red label.

Label "red":
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Insect Repellent Lotion
Direction
Pharmacist:

Date:
Uses:
Topical lotion can be applied on the skin to prevent insect attack.
-7 -
with best wishes *** Iman***
Zinc oxide ointment
x
Zinc Oxide (protectant)
Before
"F"
200 gm
Mineral Oil (liquid paraffin) (emollient)
150 gm
White oitment (emollient & oinment base)
650 gm
After "F"
Fiat: Ointment
Mitte: 25gm
Sig.: UD

Calculation:
F = 25 / 1000 = 0.025

Procedure:
1. In a mortar, levigate well using pestle the zinc oxide and mineral oil, till white paste
is formed.
2. Add geometrically the amount of white ointment till very smooth ointment is
formed.
3. Transfer to a clean close container and fix red label.

Label "red":
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Zinc Oxide Ointment
Direction
Pharmacist:

Date:
Uses:
1- has a mild astringgent effect, protectant and antiseptic action.
2- Used in tx of eczema, psoriasis, pruritus and varicose ulcers.
-8 -
with best wishes *** Iman***
White Ointment "Simple oinment"


x
Before "F"
White Soft Paraffin
950 gm
White wax
50 gm
After "F"
Calculation:
F=

Procedure:
1. In a porcalain dish at the water bath, melt white wax until it liquified.
2. Then add to it the white soft paraffin. Mix well using the pestle until a homogenous
mixture is formed.
3. Remove from water bath and continue stirring till cold and white ointment is formed.
4. weight the needed amount of the white oinemtnt as used as directed
-9 -
with best wishes *** Iman***
Isoniazide Suspension for Children
x
Before "F"
After "F"
Nydrazide® tablets (100mg/each # 12 tablets
tablet)
(active ingreadeint) (a. I.)
Distilled water (cosolvent)
20ml
30%aqueous Sorbitol solution
(vehicle)
q.s ad to 120ml
Fiat: Suspension
Mitte: 60ml
Sig.: 1 tbls 4 x 3/7

Calculation:
1.
2.
3.
F = M / Rx = 60/120 = 0.5
amount of vehicle "
"=
1/2 amount of vehicle "

Procedure:
1.
2.
3.
4.
5.
6.
Pulverize the tablets in a mortar using the pestle.
Levigate with the distilled water until smooth paste is formed.
Then add, the sorbitol (1/2 amount = ).
Levigate well, using pestle, until a homogenous suspension is obtained.
Transfer to cylindrical measure and complete volume with sorbitol.
Pour into an amber glass bottle –tightly closed - fix white label.

Label: white
"=
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Pt.’s name:
Drug;
Rx #:
Isoniazide Oral Suspension
Shake Well Before Use
Refrigerate
Direction
Pharmacist:


Date:
Dose: 10 to 40 mg/kg/day.
Uses: For treatment and prophylaxis of TB.
-10 -
with best wishes *** Iman***
Ampicillin suspension
x
Before "F"
Ampicillin trihydrate (a. I)
125 mg
Distilled water (cosolvent)
2 ml
Saccharine Sodium
(artificial sweeting agent)
Methyl Cellulose 2% (vehicle)
0.008gm
After "F"
to 5ml
Fiat: Suspension.
Mitte: 60ml
Sig.: 1 tsp q 6hrs 5/7.
Calculation:

1.
2.
3.
4.

F = M / Rx = 60/5 = 12
amount of vehicle "
"=
1/2 amount of vehicle "
"=
remaining amount of the vehicle = M – reading of measure =
Procedure:
1. In a mortar, powder ampicillin using pestle, then add 1/2 amountt of vehicle (=
ml of
) mix well using pestle to make a smooth paste.
2. In a beaker dissolve saccharin sodium + water, dissolve well using glass rod.
3. Add no.2 into no.1, mix well using glass rod untill a homogenous suspension is formed
4. Then transfer to a cylindrical measure.
5. Rinse the mortar with the remainig amount of the vehicle (= ml of
) to
adjust the volume to 60 ml.
6. Transfere into clean close bottle, fix a white label.

Label: white
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Pt.’s name:
Drug;
Rx #:
Ampicillin Suspension
Shake Well Before Use
Direction
Pharmacist:
Date:
Uses: Ampicillin is a broad spectrum antibiotic mainly used for empirical treatment for
infecting caused by gram (+) bacteria such as URTI, and UTI.
-11 -
with best wishes *** Iman***
Chloramphenicol Suspension
x
Before "F"
Chloramphenicol Palmitate (a. I)
4gm
Glycerin (sp. gr. = 1.25)
(wetting agent)
Arabic gum (Acacia)
(suspending agent)
Simple syrup (sp. gr. = 1.3)
(sweeting agent)
Water (vehicle)
20gm
After "F"
10gm
50gm
q.s. to 100 ml

Fiat: Suspension.
Mitte: 25ml
Sig.: 1 tsp q6hr 2/52
Calculation:
1.
2.
3.
4.
F = M / Rx = 25/100 = 0.25
amount of vehicle "
"=
1/2 amount of vehicle "
"=
remaining amount of the vehicle = M – reading of measure =

Procedure:
1. In a mortar using pestle, triturate Chloramphenicol with glycerin and acacia, to
obtain a homogenous paste .
2. Dilute with all amount of simple syrup, mix well, using a pestle
3. Then add ½ amount of vehicle (=
ml of
) mix well using a pestle
until you have a homogenous suspension.
4. Transfer to cylindrical measure
5. Then rinse the mortar with the remaining amount of the vehicle (=
ml of
, to adjust the volume.
6. Transfere into clean close bottle, fix a white label.

Label: white:
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Shake Well Before Use
Chloramphenicol Palmitate Suspension
Direction
Pharmacist:

Date:
Uses:
Chloramphenicol
is a potent, broad spectrum antibiotic reserved for treatment of life-threatening
infections caused by Haemophilus influenza, and also for typhoid fever; Palmitate
ester is: 1. Water insoluble (suspension).
2. More palatable for oral intake.
-12 -
with best wishes *** Iman***
Clindamycin Solution
x
Before "F"
Clindamycin phosphate (a. I)
1gm
Distilled water (cosolvent)
34ml
Propylene glycol (soothing agent)
10ml
Isopropyl alcohol (vehicle)
q.s. to 100 ml
After "F"
Fiat: Solution
Mitte: 50ml
Sig.: apply BID to face

Calculation:
1.
2.
3.
4.
F = M / Rx = 50/100 = 0.5
amount of vehicle "
"=
1/2 amount of vehicle "
"=
remaining amount of the vehicle = M – reading of measure =

Procedure:
1. In a mortar,using a pestle, triturate well, clindamycin + water, to obtain a
homogenous paste.
2. Then add propylene glycol, mix well, using a pestle.
3. Then add 1/2 amount of vehicle (=
ml of
), mix well.
4. Transfer to cylindrical measure,
5. Then rinse the mortar with the remaining amount of vehicle (= ml of
) to
adjust the volume.
6. Transfere into clean close bottle, fix a red label.

Label: red
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Clindamycin Solution
Direction
Pharmacist:
Date:

Note:
Isopropyl alcohol used as a vehicle to facilitate spreading of Clindamycin on the skin
and then drying causing cooling sensation..

Uses:
Clindamysin solution used for prophylaxis and tretment of acne valgaris.
-13 -
with best wishes *** Iman***
Indomethacin Syrup
x
Before "F"
Indomethacin (a. I.)
200 mg
Ethyl alcohol (solvent)
10 ml
Methyl paraben (preservative)
0.5 mg
Propyl paraben (preservative)
0.5 mg
Simple syrup (solvent)
q.s. to 100 ml
After "F"
Fiat: Syrup
Mitte: 25 ml
Sig.: 1 tsp q8hrs pc x 2/52.

Calculation:
1. F = M / Rx = 60/5 = 12
2. amount of vehicle "
3. 1/2 amount of vehicle "

"=
"=
Procedure:
1. Since indomethacin insolulbe in water so, prepare the vehicle in a beaker
{ethyl alcohol + 1/2 amount of vehicle (= ml of
) mix well using a glass rod.
2. after preparation of the vehicle , add to it the indomethacin and dissolve well
using glass rod, until clear solution is obtain.
3. Then add methyl paraben + propyl paraben dissolve well using glass rod.
4. Transfere to a cylindrical measure , complete the volume using the simple syrup,
mix well using glass rod.
5. Transfere to clean closed bottle, fix a white label.

Label: white
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Pt.’s name:
Drug;
Rx #:
Indomethacin Syrup
Direction
Pharmacist:

Date:
Uses: Indomethacin act as analgesic, antipyretic and anti-inflammatory drug. It is used in
rheumatic disorders such as osteoarthritis and rheumatoid arthritis.
-14 -
with best wishes *** Iman***
Indomethacin Suppository
The following formula used to prepare one suppository"
Before "F"
After "F"
x

Indomethacin (a. I)
100 mg
Stearic acid (supp. Base)
0.5 gm
Oleic acid (supp. Base)
0.5 gm
Fiat: Suppositories.
Mitte: III.
D.V. : 1.1
Sig.: U. D.
Calculation:
1. No. of suppositories = M + 6 Excess)=
2. amount of a. I (drug) = wt. x No. of suppositories=
3. Amount of suppositories base = mould capacity x no. of supp. – (amount of drug
/ displacement value for the drug)

Procedure:
1. Select the suppository mould and make your calculation according to the mould capacity
(either 1 gm or 2 gm).
2. Clean the suppository mould, invert it to remove excess water, then lubricate it with soap
lubricant using a piece of cotton, then invert it to remove the excess.
3. In a porcalain dish at the water bath, melt the stearic acid tell it liquified.
4. then add the oleic acid, keep on water bath tell warming, mix well the mixture using
pestle.
5. Add the indomethacin, mix well using a pestle, then pour the hot mixture into the
suppository mould, make over flow
6. Keep in refrigeratore, until solidified, smoothing the surface of the suppositories by
knife, then open the mould and select the best THREE suppositories, wrapped into
aluminum foil, fix a red label.

Label: red
COLLEGE OF PHARMACY
Department of Pharmaceutics
Dr.’s name:
Rx #:
Pt.’s name:
Drug;
Indomethacin suppositories
(Three suppositories)
Direction
Pharmacist:

Date:
uses: as previous page.
-15 -
with best wishes *** Iman***