荷兰鹿特丹伊拉斯姆斯大学博士项目
为配合留学生基金委（CSC）项目，荷兰鹿特丹伊拉斯姆斯大学现向我校开放博士项目申请其相应信
息现公布如下：
1、 对口学院：
Erasmus Medical Center (同时需求工科学生) – 四川大学基础医学院, 临床医学院, 物理学院, 生物学
院, 化学院, 机械工程学院, 信息与通信工程学院, 电气工程学院, 计算机科学与技术学院
Institute of Health Policy and Management – 四川大学公共卫生与预防医学院
Erasmus School of Law – 四川大学法学院
Rotterdam School of Management – 四川大学工商管理学院, 金融学
Faculty of School Science – 四川大学社会学院
Institute of Social Studies –四川大学社会学院
2、 项目整体介绍表一上面有所有教授和辅导老师的名字、邮箱、所在学院、提供的项目数量、对学生的
背景和英语要求。
3、 各学院的项目具体介绍并附有教授们近几年在世界上各个领域发表的文章。
（点击下面超链接）
Erasmus Medical Center 介绍，而且 Erasmus 大学医学部的十位教授希望招取有工科背景的学生, 比如
来自 Computer Science, Physics, Electrical Engineering 等专业的学生,主要是 考虑到工科在医学上的应用.
关于工科学生的具体要求见 Erasmus Medical Center - Tech
Institute of Health Policy and Management 介绍
Erasmus School of Law 介绍
Rotterdam School of Management 介绍
Faculty of Social Sciences 介绍
Institute of Social Studies 介绍
表一
EUR CSC PhD Project Overview 2012
Supervisor(s)
Co-Supervisor(s)
E-mail adresses
Departme
nt
Proj
ect
Desc
rip.
Required
Background
English
Require
ments
j.coebergh@erasmusmc.nl
l.liu@erasmusmc.nl
Public
Health
3
Epidemiologi
cal, Staistical
Training
IELTS: 7
(min. 6
per
sub-scor
e)
Erasmus Medical Center
Prof. Jan Willem Coebergh
Drs. Lifang Liu
Dr. Carola Zillikens
m.c.zillikens@erasmusmc.nl
Epidemiol
ogy
1
Statistics,
Medicine or
Biology
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Ronald de Krijger
r.dekrijger@erasmusmc.nl
Medicine
1
Molecular
Biology
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Axel P.N. Themmen
Dr. Jenny A. Visser
a.themmen@erasmusmc.nl
j.visser@erasmusmc.nl
Internal
Medicine
1
Molecular
Biology,
preferably
with
knowledge of
Physiology
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. M. Van Driel
Prof. J. Van Leeuwen
m.vandriel@erasmusmc.nl
j.vanleeuwen@erasmusmc.nl
Internal
Medicine,
Laborator
y
for
Calcium
and Bone
metabolis
m.
1
Cell biology,
molecular
biology
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Carla Baan
(Prof. W. Weimar)
c.c.baan@erasmusmc.nl
w.weimar@erasmusmc.nl
Internal
Medicine Kidney
Transplant
ation
1
Immunology
IELTS:
7.5 (min.
6
per
sub-scor
e)
Prof. Teun van Gelder
t.vangelder@erasmusmc.nl
Hospital
Pharmacy
and
Internal
Medicine
Clinical
Pharmacol
ogy Unit
2
Pharmacy or
Medicine
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. John Hays
Dr. W. Goessens
Dr. M. van Westreenen
j.hays@erasmusmc.nl
w.goessens@erasmusmc.nl
m.vanwestreenen@erasmusmc.nl
Medical
Microbiol
ogy
&
Infectious
Diseases
1
Medical
Microbiology
or
Bioinformati
cs
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Henri Braat
h.braat@erasmusmc.nl
Gastroente
rology and
Hepatolog
y
1
Gastroenterol
ogy
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. H.L.A. Janssen
Prof. M.P. Peppelenbosch
Drs. Q. Pan
h.janssen@erasmusmc.nl
m.peppelenbosch@erasmusmc.nl
q.pan@erasmusmc.nl
Gastroente
rology and
Hepatolog
y
1
Molecular
Biology, Cell
Biology
or Virology
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Reno. Debets
j.debets@erasmusmc.nl
Medical
Oncology
Laborator
y
of
Experime
ntal
Tumor
Immunolo
gy
1
Molecular
Biology and
Immunology
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Jozien Helleman
j.helleman@erasmusmc.nl
p.berns@erasmusmc.nl
s.sleijfer@erasmusmc.nl
Medical
Oncology
1
Molecular
Biology
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. J.A. Foekens
Dr. A.M. Sieuwerts
Dr. J.W. Martens
Dr. A. Umar
j.foekens@erasmusmc.nl
a.sieuwerts@erasmusmc.nl
j.martens@erasmusmc.nl
a.umar@erasmusmc.nl
Medical
Oncology,
Post-gradu
ate school
of
Molecular
Medicine
3
Molecular
Biology with
affinity
for genomics
research.
IELTS: 7
(min. 6
per
sub-scor
e)
Prof.
A.C.S
Hokken-Koelega
Dr. Laura de Graaff
a.hokken@erasmusmc.nl
l.degraaff@erasmusmc.nl
Pediatrics
1
(Medical)
Biology or
Medicine
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Johan Kros
j.m.kros@erasmusmc.nl
j.beekman@erasmusmc.nl
Pathology
Neuropath
ology
3
Medicine,
Biomedical
Science,
Biochemistry
or Medical
Biology
IELTS: 7
(min. 6
per
sub-scor
e)
Ass. Prof. Kok
d.kok@erasmusmc.nl
Urology
2
Microbiology
, Medicine
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Peter Patka
p.patka@erasmusmc.nl
Trauma
Surgery
and
Emergenc
y
1
Emergency
Medicine,
Public Health
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Manfred Kayser
Dr. Fan Liu
m.kayser@erasmusmc.nl
f.liu@erasmusmc.nl
Forensic
Molecular
Biology
1
Bioinformati
cs, computer
science,
statistics,
epidemiology
or
related
fields
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Marleen de Bruijne
marleen.debruijne@erasmusmc.nl
Biomedica
l Imaging
Group
Rotterdam
(BIGR)
www.bigr.
nl
2
Physics,
electrical
engineering,
mathematics,
biomedical
engineering,
computer
science, or a
related field.
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Erik. Meijering
(Prof. Wiro Niessen)
meijering@imagescience.org
w.niessen@erasmusmc.nl
Medical
Informatic
s
and
Radiology
Biomedica
l Imaging
Group
Rotterdam
1
Mathematics,
Physics,
Electrical
Engineering,
Biomedical
Engineering,
Computer
Science or a
related field
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Ton van der Steen
Dr. Evelyn Regar
Ass. Prof. Gijs van Soest
a.vandersteen@erasmusmc.nl
e.regar@erasmusmc.nl
g.vansoest@erasmusmc.nl
Thorax
Center
Departme
nt
of
Interventi
onal
Cardiolog
y
Departme
nt
of
Biomedica
l
Engineeri
ng
1
Candidates in
the Depts. Of
Interventiona
l Cardiology
and
Biomedical
Engineering,
Thorax
Center,
Erasmus MC
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Heleen van Beusekom
Dr. J.J. Wentzel
Ass. Prof. Gijs van Soest
Prof. Ton van der Steen
h.vanbeusekom@erasmusmc.nl
j.wentzel@erasmusmc.nl
g.vansoest@erasmusmc.nl
a.vandersteen@erasmusmc.nl
Thorax
Center
Departme
nt
of
Experime
ntal
Cardiolog
y
Departme
nt
of
Biomedica
l
Engineeri
ng
1
Biochemistry
or
mass
spectrometry,
and
a
background
in Chemistry,
Biology, or
Physics, with
a
keen
interest
in
Medicine,
particularly
cardiology
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Frank Gijsen
Dr. Lambert Speelman
Prof. Ton van der Steen
f.gijsen@erasmusmc.nl
l.speelman@erasmusmc.nl
a.vandersteen@erasmusmc.nl
Biomedica
l
Engineeri
ng
and
Experime
ntal
Cardiolog
y
1
Biomedical
engineering
or imaging
with a keen
interest
in
MR imaging
and
image
processing
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Ben J.M. HeijmenDr.
Mischa S. Hoogeman
b.heijmen@erasmusmc.nlm.hooge
man@erasmusmc.nl
Radiation
Oncology
1
Computer
Science,
Physics, or
Applied
Mathematics
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Gerard van Rhoon
Maarten Paulides
Jurriaan Bakker
g.c.vanrhoon@erasmusmc.nl
m.paulides@erasmusmc.nl
j.bakker@erasmusmc.nl
Radiation
Oncology
1
Electrical/Bi
omedical
Engineering,
Physics
or
equivalent
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Hans van der Steen
j.vandersteen@erasmusmc.nl
Neuroscie
nce
1
Neurology,
Health
Technology
Engineering,
Mathematics
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Gerard Borst
g.borst@erasmusmc.nl
Neuroscie
nce
1
Neuroscience
,
Biology,
Medicine,
Physics
IELTS: 7
(min. 6
per
sub-scor
e)
1
Master
of
Laws (LLM);
with special
IELTS: 7
(min. 6
per
Institute of Health Policy and Management
Ernst Hulst, LLM
hulst@bmg.eur.nl
interest
Health
Ethics.
in
sub-scor
e)
Prof. Martin Buijsen
buijsen@bmg.eur.nl
denexter@bmg.eur.nl
1
Master
of
Laws
(LL
M);
with
special
interest
in
Health law
and/or Social
insurance
law
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Martin Buijsen
buijsen@bmg.eur.nl
denexter@bmg.eur.nl
1
Master
of
Laws (LLM);
with special
interest
in
(Public)
Health law
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Joris van de Klundert
Dr. Jeroen van Oostrum
vandeklundert@bmg.eur.nl
vanoostrum@bmg.eur.nl
1
Operations
Research,
Applied
Mathematics
or equivalent
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Martin Buijsen
buijsen@bmg.eur.nl
denexter@bmg.eur.nl
1
Master
of
Laws (LLM);
with special
interest
in
Health law
and/or
Pharmaceutic
al law
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Martin Buijsen
buijsen@bmg.eur.nl
denexter@bmg.eur.nl
1
Master
of
Laws (LLM);
with special
interest
in
Health law
and/or
International
law
IELTS: 7
(min. 6
per
sub-scor
e)
2
Business
Administrati
on,
Psychology,
Sociology,
IELTS:
7.5 (min.
6
per
sub-scor
e)
Erasmus School of Law
Rotterdam School of Management / Erasmus School of Economics
Prof. Jan van den Ende
Dr. Serge A. Rijsdijk
jende@rsm.nl
srijsdijk@rsm.nl
Managem
ent
of
Technolog
y
and
Innovation
Economy,
Technology
or equivalent
GMAT:
680
Prof. Barbara Krug
Dr. Mark Greeven
BKrug@rsm.nl
MGreeven@rsm.nl
Research
Centre on
China
Business
1
Management,
Economics
or Political
Science
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Nishant Mishra
nmishra@rsm.nl
Operation
s
Managem
ent Group
Managem
ent
of
Technolog
y
and
Innovation
2
Preferably a
bachelor’s
and / or a
master’s
degree
in
industrial
engineering,
operations
research,
mathematics
or computer
science
IELTS:
7.5 (min.
6
per
sub-scor
e)
GMAT:
680
Prof. M.B.M. de Koster
Prof. R. Dekker
Prof. H. Geerlings
rkoster@rsm.nl
rdekker@ese.eur.nl
geerlings@fsw.eur.nl
Rotterdam
School of
Managem
ent
/
Erasmus
School of
Economic
s
2
Quantitative
methods, in
particular
operations
research,
Master:
Mathematics,
Econometrics
, (Industrial)
Engineering,
or Computer
science
IELTS:
7.5 (min.
6
per
sub-scor
e)
GMAT:
650
Prof. Rob A. Zuidwijk
rzuidwijk@rsm.nl
Rotterdam
School of
Managem
ent
/
Erasmus
School of
Economic
s
1
Econometrics
, Operations
Research,
Industrial
Engineering,
or
comparable
degree with a
substantial
affiliation
with
quantitative
modeling.
IELTS:
7.5 (min.
6
per
sub-scor
e)
GMAT:
680
Prof. Pursey Heugens
pheugens@rsm.nl
Strategic
Managem
ent
and
Entrepren
eurship
1
Management,
Sociology or
Economics
IELTS:
7.5 (min.
6
per
sub-scor
e)
GMAT:
700
Prof. Jack Burgers
burgers@fsw.eur.nl
Social
Sciences
Erasmus
University
Research
Group
‘Citizensh
ip,
Migration
and
the
City’
(CIMIC)
1
Urban
studies,
sociology,
social
or
human
geography,
anthropology
.
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Godfried Engbersen
Prof. Arjen Leerkes
Engbersen@fsw.eur.nl
Social
Sciences
Research
Group
‘Citizensh
ip,
Migration
and
the
City’
(CIMIC)
2
Political or
Social
Sciences
(including
Criminology,
Migration
Studies,
Sociology,
Social
or
Human
Geography)
IELTS: 7
(min. 6
per
sub-scor
e)
Dr. Willem Schinkel
Schinkel@fsw.eur.nl
Sociology
1
Sociology,
anthropology
, ethnography
IELTS: 7
(min. 6
per
sub-scor
e)
Prof. Dick Houtman
Dr. Stef Aupers
Dr. Peter Achterberg
houtman@fsw.eur.nl
aupers@fsw.eur.nl
p.achterberg@fsw.eur.nl
Sociology
2
(Cultural)
Sociology,
Anthropolog
y,
Social
Science
IELTS: 7
(min. 6
per
sub-scor
e)
mpvandijk@iss.nl
Social
Study
1
Economics
or
another
social
science
IELTS: 7
(min. 6
per
sub-scor
Faculty of Social Sciences
Institute of Social Studies
Prof. Meine Pieter van
Dijk
e)
Prof. Bert Helmsing
Prof. Meine Pieter van
Dijk
helmsing@iss.nl
mpvandijk@iss.nl
Social
Study
1
Total
59
Regional
economics
and
economic
geography
Erasmus Medical Center
Dr. Carla Baan
School/Depar Erasmus University Medical Center Rotterdam
Department of Internal Medicine-Kidney Transplantation Rotterdam
tment:
The Netherlands
Project Title: Follicular helper T cells in kidney transplant patients during allograft rejection.
Over the past decade antibody mediated, humoral B cell mediated rejection has
Abstract:
been recognized as a distinct and common cause of graft dysfunction and
predict both early and late graft loss after organ transplantation. The incidence
of antibody mediated rejection varies between 1-8% and is present in 30% of
renal biopsies from patients that have been diagnosed with acute rejection.
Diagnosis requires a biopsy and demonstration of the complement degradation
product, C4d in peritubular and/or glomerular capillaries. Because of its
association with preformed antibodies to HLA in recipients, vascular presence
of complement fragment C4d has been assumed to represent humoral immune
reaction against graft endothelial cells. It is also thought that these poorly
defined alloimmune responses persistent at a low-grade level during the entire
life span of the graft, is refractory to treatment with conventional
immunosuppression and results in irretrievable loss of graft. Therefore, detailed
knowledge of the mechanisms that determine influx of the rejection infiltrate
and the mechanisms of continuous alloantigenic immune responses is required
to design therapeutic strategies that target antibody mediated rejection.
This research project proposes to study the role of T helper cells that provide
‘‘help’’ to B cells and regulate their immune globulin production. The recently
described T helper cell subset called T follicular helper (Tfh) cells, antigen
experienced CD4T cells that are characterized by their expression of chemokine
(C-X-C motif) receptor 5 (CXCR5), inducible costimulator (ICOS), and the
transcription factor B cell lymphoma (BCL) 6 have been shown to regulate
antibody mediated immunity.
The goal of this research project is to define the role of Tfh cells in rejection
after kidney transplantation.
Requirement Background: Biology or Medicine. Candidate should be educated in
s
of immunology and be trained in laboratory techniques like flow cytometry, cell
culture and PCR.
candidate:
Master degree: Yes
IELTS Grade: 7.5 (min. 6.0 per sub-score)or
IELTS: 7
(min. 6
per
sub-scor
e)
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information:
Supervisor: Dr. C.C. Baan
E-mail: c.c.baan@erasmusmc.nl
Dept of Internal Medicine P.O. Box 2040, Room EE559
3000 CA Rotterdam,
The Netherlands
Website: http://nl.linkedin.com/pub/carla-baan/8/a19/960
List of recent publications:
1.
Dijke IE, Caliskan K, Korevaar SS, Maat AP, Zondervan PE, Balk AH,
Weimar W, Baan CC. FOXP3 mRNA expression analysis in the peripheral
blood and allograft of heart transplant patients. Transpl Immunol.
2008;18(3):250-4.
2.
Sewgobind VD, van der Laan LJ, Klepper M, IJzermans JN, Tilanus HW,
Weimar W, Baan CC. Functional analysis of CD4(+) CD25(bright) T cells in
kidney transplant patients: improving suppression of donor-directed responses
after transplantation. Clin Transplant. 2008;22:579-86.
3.
Dijke IE, Weimar W, Baan CC. Regulatory T cells after organ
transplantation: where does their action take place? Hum Immunol.
2008;69(7):389-98. Invited Review.
4.
Hoogduijn MJ, Crop MJ, Korevaar SS, Peeters AMA, Eijken M, Maat
LPWM, Balk AHMM, Weimar W, Baan CC. Susceptibility of Human
Mesenchymal Stem Cells to Tacrolimus, Mycophenolic acid and Rapamycin.
Transplantation 2008;86(9):1283-91.
5.
van Besouw NM, van de Wetering J, van der Mast BJ, de Kuiper R, Baan CC,
Weimar W. After discontinuation of calcineurin inhibitors, tapering of
mycophenolate mofetil further impairs donor-directed cytotoxicity. Clin
Transplant. 2008;22(2):129-35.
6.
Demirkiran A. Hendrikx TK, Baan CC, van der Laan LJ. Impact of
immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does
in vitro evidence translate to the clinical setting? Transplantation.
2008;85(6):783-9. Review.
7.
Crop M, Baan C, Weimar W, Hoogduijn M. Mesenchymal stem cells as
immune therapy in solid-organ transplantation. Transplant Int 2008 Epub
Invited Review.
8.
Dijke IE, Caliskan K, Klepper M, de Kuiper R, Balk AH, Maat AP, Weimar
W, Baan CC. Donor-specific Immune Regulation by CD8(+) Lymphocytes
Expanded from Rejecting Human Cardiac Allografts. Am J Transplant.
2009;9:397-03.
9.
Hoogduijn MJ, Crop MJ, Peeters AM, Korevaar SS, Eijken M, Drabbels JJ,
Roelen DL, Maat AP, Balk AH, Weimar W, Baan CC. Donor-Derived
Mesenchymal Stem Cells Remain Present and Functional in the Transplanted
Human Heart. Am J Transplant. 2009;9:222-30.
10. Crop MJ, Baan CC, Korevaar SS, IJzermans JNM, Alwayn IPJ, Weimar W,
Hoogduijn MJ. Donor derived mesenchymal stem cells suppress alloreactivity
of kidney transplant patients. Transplantation 2009;87:896-06.
11. Demirkiran A, Sewgobind VDHD, van der Weijde J, Kok A, Baan CC,
Kwekkeboom J, Tilanus HW,
Metselaar HJ, van der Laan LJW. Conversion
from calcineurin inhibitor to mycophenolate mofetil-based
immunesuppression changes the frequency and phenotype of CD4 +FoxP3+
regulatory T cells. Transplantation 2009;87:1062-68.
12. Van Gurp EAFJ, Schoordijk-Verschoor W, Klepper M, Korevaar SS, Chan G,
Weimar W, Baan CC. The effect of the JAK inhibitor CP-690,550 on
peripheral immune parameters in stable kidney allograft patients.
Transplantation 2009;87:79-86.
13. Hendrikx TK, Van Gurp EAFJ, Sewgobind VDKD,
W,
Klepper M, Velthuis JHL,
Mol WM, Schoordijk
Geel A, IJzermans JNM, Weimar W, Baan
CC. Generation of donor-specific regulatory T cells in kidney transplant
patients Transplantation 2009;87:376-83.
14. Sewgobind VDKD, Kho ML, van der Laan LJW, Hendrikx TK, van Dam T,
Tilanus HW, Ijzermans JNM, Weimar W, Baan CC. The Effect of Rabbit
Anti-thymocyte Globulin Induction Therapy on Regulatory T cells in Kidney
Transplant Patients. Nephrology Transplantation and Dialysis
2009;24:1635-44.
15. Hendrikx TK, van Gurp EAFJ, Mol WM, Schoordijk W, Sewgobind VDKD,
IJzermans JNM, Weimar W, Baan CC. End stage renal failure and regulatory
activities of CD4+CD25bright+FoxP3+T-cells. Nephrology Transplantation and
Dialysis 2009;24:1969-78..
16. Dijke IE, Korevaar SS, Caliskan K, Balk AH, Maat AP, Weimar W, Baan
CC. Inadequate immune regulatory function of CD4+CD25bright+FoxP3+ T
cells in heart transplant patients who experience acute cellular
rejection.Transplantation 2009;87:1191-200.
17. Hendrikx TK, Klepper M, IJzermans J, Weimar W, Baan CC. Clinical
rejection and persistent immune regulation in kidney transplant patients.
Transplant Immunol. 2009;21:129-35.
18. Hendrikx TK, Velthuis JH, Klepper M, Van Gurp E, Geel A, Schoordijk W,
Baan CC, Weimar W. Monotherapy rapamycin allows an increase of
CD4CD25foxp3 T cells in renal recipients. Transpl Int. 2009;22:884-91.
19. Van Besouw NM, De Kuiper R, Van Der Mast BJ, Van De Wetering J, Baan
CC, Weimar W. Deficient TNF-alpha and IFN-gamma production correlates
with nondetectable donor-specific cytotoxicity after clinical kidney
transplantation. Transplantation. 2009;87:1451-4.
20. Baan CC, Dijke IE, Weimar W. Regulatory T cells in alloreactivity after
clinical heart transplantation. Curr Opin Organ Transplant. 2009;14:577-82.
21. Sombogaard F, Peeters AM, Baan CC, Mathot RA, Quaedackers ME, Vulto
AG, Weimar W, van Gelder T. Inosine monophosphate dehydrogenase
messenger RNA expression is correlated to clinical outcomes in
mycophenolate mofetil-treated kidney transplant patients, whereas inosine
monophosphate dehydrogenase activity is not. Ther Drug Monit.
2009;31(5):549-56
22. Dahlke MH, Hoogduijn M, Eggenhofer E, Popp FC, Renner P, Slowik P,
Rosenauer A, Piso P, Geissler EK, Lange C, Chabannes D, Mazzanti B,
Bigenzahn S, Bertolino P, Kunter U, Introna M, Rambaldi A, Capelli C,
Perico N, Casiraghi F, Noris M, Gotti E, Seifert M, Saccardi R, Verspaget
HW, van Hoek B, Bartholomew A, Wekerle T, Volk HD, Remuzzi G, Deans
R, Lazarus H, Schlitt HJ, Baan CC; MISOT Study Group. Toward MSC in
solid organ transplantation: 2008 position paper of the MISOT study group
Transplantation. 2009;88:614-9.
23. Quaedackers ME, Baan CC, Weimar W, Hoogduijn MJ. Cell contact
interaction between adipose-derived stromal cells and allo-activated T
lymphocytes. Eur J Immunol. 2009;39:3436-46.
24. Quaedackers ME, Mol W, Korevaar SS, van Gurp EA, van Ijcken WF, Chan
G, Weimar W, Baan CC. Monitoring of the immunomodulatory effect of
CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant
patients. Transplantation. 2009;88:1002-9.
25. Sewgobind VD, van der Laan LJ, Kho MM, Kraaijeveld R, Korevaar SS, van
Dam T, IJzermans JN, Weimar W, Baan CC. Characterization of Rabbit
Antithymocyte Globulins-Induced CD25+ Regulatory T Cells From Cells of
Patients With End-Stage Renal Disease. Transplantation 2010;89:655-66.
26. Crop M, Baan CC, Korevaar SS, Ijzermans JN, Weimar W, Hoogduijn MJ.
Human adipose tissue-derived mesenchymal stem cells induce explosive
T-cell proliferation. Stem Cells Dev. 2010 19(12):1843-53.
27. Hoogduijn MJ, Popp FC, Grohner A, Crop MJ, Rhijn van M, Eggenhofer E,
Renner P, Reinders ME,
Rabelink TJ, Laan van der L, Genever PG,
C, Durrbach A, Houtgraaf JH, Christ B, Seifert M,
V, Deans R,
Ringden O,
Perico N,
Remuzz G,
Lange
Shagidulin M, Donckier
Bartholomew A,
Schlitt HJ, W Weimar W, Baan CC, Dahlke MH; the MISOT study group.
Advancement of Mesenchymal stem cell therapy in Solid Organ
Transplantation (MISOT). Transplantation 2010; 90(2):124-6.
28. Sewgobind VD, van der Laan LJ, Kho MM, Kraaijeveld R, Korevaar SS, Mol
W, Weimar W, Baan CC. The calcineurin inhibitor tacrolimus allows the
induction of functional CD4(+)CD25(+) regulatory T cells by rabbit
anti-thymocyte globulins. Clin Exp Immunol. 2010 161(2):364-77.
29. Crop MJ, Baan CC, Korevaar SS, Ijzermans JN, Pescatori M, Stubbs AP, Van
Ijcken WF, Dahlke MH, Eggenhofer E, Weimar W, Hoogduijn MJ.
Inflammatory conditions affect gene expression and function of human
adipose tissue-derived mesenchymal stem cells. Clin Exp Immunol.
2010;162(3):474-86.
30. Sewgobind VD, Quaedackers ME, van der Laan LJ, Kraaijeveld R, Korevaar
SS, Chan G, Weimar W, Baan CC. The Jak inhibitor CP-690,550 preserves
the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T
cells. Am J Transplant. 2010;10(8):1785-95.
31. Baan CC. iTregs by vitamins. Commentary on “Retinoic acid attenuates acute
heart rejection by increasing regulatory T cell and repressing differentiation of
Th17 in the presence of TGF-β” Transplant Int 2010; 23(10):984-85.
32. Hoogduijn MJ, Popp F, Verbeek R, Masoodi M, Nicolaou A, Baan C, Dahlke
MH. The immunomodulatory properties of mesenchymal stem cells and their
use for immunotherapy. Int Immunopharmacol. 2010;10:1496-1500.
33. Weetering van J, Koumoutsakos P, Weimar W, Baan CC. Discontinuation of
calcineurin inhibitor treatment allows the development of FOXP3+ regulatory
T cells in patients after transplantation. Clin Transplantation. Clin Transplant.
2011;25(1):40-6.
34. Baan CC, Weimar W. How does auxiliary liver transplantation regulate
alloreactivity in sensitized kidney transplant patients? Transplantation 2011;
91(8):823-4.
35. Baan CC, Gaston B. Am J Transplant 2011;11(4):681-6.
36. Crop MJ, Korevaar SS, de Kuiper R, Ijzermans JN, van Besouw NM, Baan
CC, Weimar W, Hoogduijn MJ. Human mesenchymal stem cells are
susceptible to lysis by CD8+ T-cells and NK cells. Cell Transplant. 2011 (in
press).
Dr. Carola Zillikens
School/Facu
lty:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
Department of Epidemiology The Netherlands
Requirement
s
of
candidate:
Supervisor
information:
Background: Statistics, Medicine or Biology
Master degree: yes
IELTS: 7 (min. 6.0 per sub-score)
Study on improved understanding of the genetic background of metabolic
diseases including gene-environment interactions.
Recent Genome-wide association studies (GWAS) have identified multiple
genetic loci associated with metabolic traits such as body mass index, waist-to
hip ratio, body composition and bone mineral density. Follow-up studies on
these loci are needed. Also, gene-environment interactions (such as interaction
between nutrition and genetic variants) and the search for rare genetic variants
that may explain part of the “missing heritability” need to be performed. Many
of these GWAS studies are performed currently within international consortia.
This also offers the unique opportunity to study association with candidate gene
and to perform gene-environment interaction studies within well-powered
settings. Also classical epidemiological studies can be performed within these
consortia.
Within the current PhD project the PhD student would perform candidate gene
and GWAS studies and study gene-environment interaction on metabolic traits
and would also be involved in statistical analyses of next-generation sequencing
data.
Carola Zillikens, MD, PhD, internist-endocrinologist at Erasmus MC with
background in (genetic) epidemiology on the topics metabolic diseases,
nutrition and osteoporosis
E-mail: m.c.zillikens@erasmusmc.nl
List of recent publications:
-Yazdanpanah N, Uitterlinden AG, et al.. Low dietary riboflavin but not folate
predicts increased fracture risk in postmenopausal women homozygous for the
MTHFR 677 T allele. J Bone Miner Res 2008;23(1):86-94.
-van Hoek M, Dehghan A, et al. An RBP4 promoter polymorphism increases risk of
type 2 diabetes. Diabetologia 2008;51(8):1423-8.
-Zillikens MC, Wijbenga A. Images in clinical medicine. Extracapsular hemorrhage
from a parathyroid adenoma. N Engl J Med 2008;359(11):1155.
-Zillikens MC, Yazdanpanah M, et al. Sex-specific genetic effects influence
variation in body composition. Diabetologia 2008;51(12):2233-41.
-Willer CJ, Speliotes EK, et al. Six new loci associated with body mass index
highlight a neuronal influence on body weight regulation. Nat Genet
2009;41(1):25-34
-Zillikens MC, van Meurs JB, et al.. SIRT1 genetic variation and mortality in type
2 diabetes: interaction with smoking and dietary niacin. Free Radic Biol Med
2009;46(6):836-41.
-Berends AL, Zillikens MC, de Groot CJ, Rivadeneira F, Oostra BA, van Duijn
CM, Steegers EA. Body composition by dual-energy X-ray absorptiometry in
women with previous pre-eclampsia or small-for-gestational-age offspring. BJOG
2009;116(3):442-51.
-Hoorn EJ, Zillikens MC, et al. Osmomediated natriuresis in humans: the role of
vasopressin and tubular calcium sensing. Nephrol Dial Transplant. 2009
Nov;24(11):3326-33..
-Lindgren CM, Heid IM,
et al. Genome-wide association scan meta-analysis
identifies three Loci influencing adiposity and fat distribution. PLoS Genet
2009;5(6):e1000508.
-Heard-Costa NL*, Zillikens MC*,et al. NRXN3 is a novel locus for waist
circumference: a genome-wide association study from the CHARGE Consortium.
PLoS Genet 2009;5(6):e1000539.
-Zillikens MC, van Meurs JB, et al. SIRT1 genetic variation is related to body mass
index
and
risk
of
obesity.
Diabetes,
under
revision.
Diabetes.
2009
Dec;58(12):2828-34.
-Zillikens MC, Uitterlinden AG, et al. The role of body mass index, insulin and
adiponectin in the relation between fat distribution and bone mineral density. Calcif
Tissue Int. 2010 Feb;86(2):116-25. Epub 2009 Dec 3.
-Pecioska S, Zillikens MC,
et al. Association between type 2 diabetes loci and
measures of fatness. PLoS One. 2010 Jan 1;5(1):e8541.
-Rivadeneira F*, Styrkarsdottir U*et al. Twenty bone mineral density loci identified
by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009
-Richards JB, Kavvoura FK, et al. Genetic Factors for Osteoporosis Consortium.. A
Systematic Evaluation of 150 Candidate Genes for their Association with
Osteoporosis and Osteoporotic Fracture in a Meta-Analysis of Genome-Wide
Association Data. Ann Intern Med. 2009 Oct 20;151(8):528-37.
-Henneman P, Janssens AC, Zillikens MC, et al. Menopause impacts the relation of
plasma adiponectin levels with the metabolic syndrome. J Intern Med. 2010
Apr;267(4):402-9.
-Schuur, M, Henneman P et al.Insulin-resistance and metabolic syndrome are
related to cognition in a large family-based study. Eur J Epidemiol. 2010
Aug;25(8):561-8. Epub 2010 Jun 29.
- Henneman P, Aulchenko YS,
et al. The genetic architecture of plasma
adiponectin overlaps with the genetics of metabolic syndrome related traits.
Diabetes Care. 2010 Apr;33(4):908-13.
-Zillikens MC, van Meurs JB, et al. Interactions between diet and SIRT1 genetic
variation influence body mass index. Am J Clin Nutr. 2010 May;91(5):1387-93..
- van den Berg LEM,
Zandbergen AAM et al.Osteopenia and osteoporosis in
Pompe disease. Muscular strength as a predictor of bone mineral density. Bone.
2010 Sep;47(3):643-9.
-Tsianos GI, Evangelou E et al..Associations of polymorphisms of eight muscle- or
metabolism-related genes with performance in Mount Olympus marathon runners. J
Appl Physiol. 2010 Mar;108(3):567-74
-Dupuis J, Langenberg C, et al. New genetic loci implicated in fasting glucose
homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010
Feb;42(2):105-16. Epub 2010 Jan 17. Erratum in: Nat Genet.2010 May;42(5):464
-Koek WN, van Meurs JB et al.The T-13910C polymorphism in the lactase
phlorizin hydrolase gene is associated with differences in serum calcium levels and
calcium intake. J Bone Miner Res. 2010 Sep;25(9):1980-7
- Köttgen A, Pattaro C, Böger et al. New loci associated with kidney function and
chronic kidney disease. Nat Genet. 2010 May;42(5):376-84
-Hsu YH*, Zillikens MC*, et al. An Integration of Genome-Wide Association
Study and Gene Expression Profiling to Prioritize the Discovery of Novel
Susceptibility Loci for Osteoporosis-Related Traits. PLoS Genet 2010 6(6):
e1000977. PMID: 20548944
-van den Berg LE, Zandbergen AA, et al. Low bone mass in Pompe disease:
muscular strength as a predictor of bone mineral density. Bone. 2010
Sep;47(3):643-9
-Nettleton JA, McKeown NM et al. Interactions of dietary whole grain intake with
fasting glucose- and insulin-related genetic loci in individuals of European descent:
a meta-analysis of 14 cohort studies. Diabetes Care. 2010 Dec;33(12):2684-91.
Epub 2010 Aug 6.2010.
-Lango AH, Estrada, K, et al. Hundreds of variants influence human height and
cluster within genomic loci and biological pathways. Nature. 2010 Oct
14;467(7317):832-8.
-Heid IM, Jackson AU, et al. Meta-analysis identifies 13 novel loci associated with
waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat
distribution. Nat Genet. 2010 Nov;42(11):949-60.
-Speliotes EK, Willer CJ et al. Association analyses of 249,796 individuals reveal
eighteen new loci associated with body mass index. Nat Genet. 2010
Nov;42(11):937-48.
- Wassenaar MJ, Biermasz NRet al. AM. High prevalence of vertebral fractures
despite normal bone mineral density in patients with long term controlled
acromegaly. Eur J Endocrinol. 2011 Jan 21. [Epub ahead of print]
-Hoorn EJ, Rivadeneira F et al. Mild hyponatremia as a risk factor for fractures: The
Rotterdam Study. J Bone Miner Res. 2011 Mar 4. doi: 10.1002/jbmr.380.
- van Lieshout MAW, Verwoert GC et al. Measures of Body Composition and Risk
of Heart Failure in the Elderly. The Rotterdam Study. J Nutr Health Aging.
2011;15(5):393-7.
- Lems WF, Raterman HG et al. Osteopenia: a diagnostic and therapeutic challenge.
Curr Osteoporos Rep. 2011 Sep;9(3):167-72.
- Kilpeläinen TO, Zillikens MC et al.Genetic variation near IRS1 associates with
reduced adiposity and an impaired metabolic profile. Nat Genet. 2011 Jun
26;43(8):753-60
- Walter S, Atzmon G, et al. A genome-wide association study of aging. Neurobiol
Aging. 2011 Jul 20. -Kanoni S, Nettleton JA, et al. Total Zinc Intake May Modify
the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort
Meta-analysis. Diabetes. 2011 Sep;60(9):2407-2416.
Dr. Evelyn Regar
School/Depart
ment:
Erasmus University Medical Center Rotterdam
Thorax Center
Department of Interventional Cardiology
Department of Biomedical Engineering
The Netherlands
The Dept. of Interventional Cardiology of the Thorax Center is focused on the
development of innovative percutaneous treatment strategies and the application of
methods for diagnostic imaging and therapy guidance.
In close collaboration with
the Depts. of Biomedical Engineering and Experimental Cardiology, research is
performed in the fields of intravascular imaging (using optical and ultrasonic
techniques), minimally invasive therapeutic devices (such as drug-eluting-,
dedicated- , or bioresorbable stents, aortic valve implants), acute myocardial
infarction, cell therapy and biomechanics. End goals are the introduction of novel
diagnostic and therapeutic strategies in the cardiology clinical practice for the
improvement of patient care.
Project Title:
Optical coherence tomography (OCT) tissue characterization for prediction of
disease progression and guidance of percutaneous coronary interventions
Abstract:
Optical coherence tomography (OCT) is a novel, high-resolution imaging
technology that has been recently introduced into interventional cardiology. OCT
has the ability to characterize the structure and extent of coronary artery disease in
unprecedented detail.
New methods for OCT image analysis are being developed in centers around the
world, to extract anatomical and compositional tissue properties. The present
project aims to evaluate the clinical role of these new technologies for prediction of
disease progression and guidance of percutaneous coronary interventions.
We will assess the role of OCT in cross sectional and in longitudinal, prospective
clinical studies, specifically designed to investigate (a) specific aspects of disease
progression (e.g. lipids, macrophages, neovascularization) as well as (b) the impact
of OCT guided procedures on patients outcome. Second/third generation OCT,
tissue characterization, automated quantitative analysis methods, including 3D
rendering, will be applied.
Requirements
of candidate:
Background: Profile for Chinese PhD candidates in the Depts. Of Interventional
Cardiology and Biomedical Engineering, Thorax Center, Erasmus MC
Master degree: yes
IELTS: 7.0 (min. 6.0 per sub-score)Or TOEFL: 100 (min. 20 per sub-score)
Other: In the context of the Rotterdam-China exchange program, sponsored by EUR
and CSC, we are currently looking for two candidates who are interested to join our
lab for a 4 year PhD program. The candidates must have a solid knowledge of
Medical Imaging or image processing, and should have a background in Medicine,
ideally Cardiology, or Physics, Electrical Engineering, Biomedical Engineering,
with a keen interest in Medicine. They have good command of English (written and
oral) and have recently received, or will receive in the coming months, an MSc
degree in one of those fields.
We are particularly interested in meeting students with research experience in
medical imaging or in interventional cardiology.
Supervisor
information:
Supervisor: Evelyn Regar, MD, PhD, FESC; Dept of Interventional Cardiology
E-mail: e.regar@erasmusmc.nl
Co-Supervisors: Gijs van Soest, PhD; Dept of Biomedical Engineering
E-mail: g.vansoest@erasmusmc.nl
Prof. Ton van der Steen, PhD, FESC; Dept of Biomedical Engineering
E-mail: a.vandersteen@erasmusmc.nl
Thorax Center
Erasmus MC
S'-Gravendijkwal 230
3015 CE Rotterdam
The Netherlands
Relevant publication list of the supervisors:
1. van Soest, G., et al., Pitfalls in Plaque Characterization by OCT: Image Artifacts
in Native Coronary Arteries. J Am Coll Cardiol Img, 2011. 4(7): p. 810-813.
2. Regar, E., et al., The diagnostic value of intracoronary optical coherence
tomography. Herz, 2011. 36(5): p. 417-429.
3. Jansen, K., et al., Intravascular photoacoustic imaging of human coronary
atherosclerosis. Opt. Lett., 2011. 36(5): p. 597-599.
4. Gutiérrez-Chico, J.L., et al., Delayed Coverage in Malapposed and Side-Branch
Struts With Respect to Well-Apposed Struts in Drug-Eluting Stents / Clinical
Perspective. Circulation, 2011. 124(5): p. 612-623.
5. Gonzalo, N., et al., Witnessed Coronary Plaque Rupture During Cardiac
Catheterization. J Am Coll Cardiol Img, 2011. 4(4): p. 437-438.
6. Gonzalo, N., et al., Relation between plaque type and dissections at the edges
after stent implantation: An optical coherence tomography study. Int J Cardiol,
2011. 150(2): p. 151-155.
7. van Soest, G., et al., Atherosclerotic tissue characterization in vivo by optical
coherence tomography attenuation imaging. J Biomed Opt, 2010. 15(1): p.
011105-9.
8. Serruys, P.W., et al., Evaluation of the Second Generation of a Bioresorbable
Everolimus Drug-Eluting Vascular Scaffold for Treatment of De Novo Coronary
Artery Stenosis: Six-Month Clinical and Imaging Outcomes. Circulation, 2010.
122(22): p. 2301-2312.
9. Schultz, C.J., et al., First-in-man clinical use of combined near-infrared
spectroscopy and intravascular ultrasound: a potential key to predict distal
embolization and no-reflow? J Am Coll Cardiol, 2010. 56(4): p. 314.
10. Regar, E., et al., Optical coherence tomography in patients with acute coronary
syndrome. EuroIntervention, 2010. 6 Suppl G: p. G154-60.
11. Onuma, Y., et al., Intracoronary Optical Coherence Tomography and Histology
at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting
Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model: An
Attempt to Decipher the Human Optical Coherence Tomography Images in the
ABSORB Trial. Circulation, 2010. 122(22): p. 2288-2300.
12. Okamura, T., et al., Reproducibility of coronary Fourier domain optical
coherence tomography: quantitative analysis of in vivo stented coronary
arteries using three different software packages. EuroIntervention, 2010. 6(3): p.
371-379.
13. Gonzalo, N., et al., Second-generation optical coherence tomography in clinical
practice. High-speed data acquisition is highly reproducible in patients
undergoing percutaneous coronary intervention.
Revista Espanola De
Cardiologia, 2010. 63(8): p. 893-903.
14. Goderie, T.P.M., et al., Combined optical coherence tomography and
intravascular
ultrasound
radio
frequency
data
analysis
for
plaque
characterization. Classification accuracy of human coronary plaques in vitro.
International Journal Of Cardiovascular Imaging, 2010. 26(8): p. 843-850.
15. Serruys, P.W., et al., A bioabsorbable everolimus-eluting coronary stent system
(ABSORB): 2-year outcomes and results from multiple imaging methods.
Lancet, 2009. 373(9667): p. 897-910.
16. Prati, F., et al., Expert review document on methodology, terminology, and
clinical applications of optical coherence tomography: physical principles,
methodology of image acquisition, and clinical application for assessment of
coronary arteries and atherosclerosis. Eur Heart J, 2009.
17. Gonzalo, N., et al., Optical coherence tomography patterns of stent restenosis.
Am Heart J, 2009. 158(2): p. 284-93.
18. Gonzalo, N., et al., Optical coherence tomography assessment of the acute
effects of stent implantation on the vessel wall: a systematic quantitative
approach. Heart, 2009. 95(23): p. 1913-9.
19. Gonzalo, N., et al., Quantitative Ex Vivo and In Vivo Comparison of Lumen
Dimensions Measured by Optical Coherence Tomography and Intravascular
Ultrasound in Human Coronary Arteries. Rev Esp Cardiol, 2009. 62(6): p.
615-624.
20. Gonzalo, N., et al., In Vivo Assessment of High-Risk Coronary Plaques at
Bifurcations With Combined Intravascular Ultrasound and Optical Coherence
Tomography. J Am Coll Cardiol Img, 2009. 2(4): p. 473-482.
21. Barlis, P., et al., Intracoronary optical coherence tomography and the evaluation
of stents. Expert Rev Med Devices, 2009. 6(2): p. 157-67.
22. Tanimoto, S., et al., A novel approach for quantitative analysis of intracoronary
optical
coherence
tomography:
High
inter-observer
agreement
with
computer-assisted contour detection. Catheter Cardiovasc Interv, 2008. 72(2): p.
228-235.
23. Ormiston, J.A., et al., A bioabsorbable everolimus-eluting coronary stent system
for patients with single de-novo coronary artery lesions (ABSORB): a
prospective open-label trial. Lancet, 2008. 371(9616): p. 899-907.
24. Barlis, P., et al., Assessment of culprit and remote coronary narrowings using
optical coherence tomography with long-term outcomes. Am J Cardiol, 2008.
102(4): p. 391-395.
25. Barlis, P., et al., Optical coherence tomography assessment of vulnerable plaque
rupture: predilection for the plaque 'shoulder'. Eur Heart J, 2008.
26. van Soest, G., et al., Robust intravascular optical coherence elastography by
line correlations. Phys Med Biol, 2007. 52(9): p. 2445-58.
27. Regar, E., T.G. van Leeuwen, and P.W. Serruys, eds. Optical Coherence
Tomography in Cardiovascular Research. 2007, Informa Healthcare: Oxon UK.
28. Regar, E., et al., Optical Coherence Tomography Findings at 5-Year Follow-Up
After Coronary Stent Implantation. Circulation, 2005. 112(23): p. e345-346.
Dr. Frank Gijsen
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Biomedical Engineering and Experimental Cardiology
The Netherlands
Project Title:
Assessment of carotid plaque vulnerability with MR strain mapping
Abstract:
Atherosclerosis is a vascular condition in which an artery wall thickens as a result of a
build-up of fatty tissue, such as cholesterol. In an advanced stage, unstable plaques
containing lipid pools and calcifications are present in the arterial wall, with a thin
fibrous cap separating the lipid pool from the blood flow. Rupture of this cap instigates
thrombosis formation, which is the major cause for stroke. Detection of unstable
plaques is essential for improvement of patient treatment strategy.
Invasive ultrasound measurements in coronary arteries have shown that strain in the
plaque can be used to identify unstable plaques. We want to apply this method in
carotid arteries of patients to separate stable from unstable plaque in a non-invasive
manner. High resolution MR imaging will be performed in patients elected for carotid
endarterectomy. After optimizing the imaging procedure, we will use dedicated
in-house developed software to determine the strain maps. The measured strain maps
based on the in-vivo MR imaging procedure will be compared to histological plaque
features to investigate whether strain imaging in carotid arteries can be used to
indentify unstable plaque in a non-invasive manner.
Requireme Background: The candidate must have a background in biomedical engineering or imaging with a
nts
of keen interest in MR imaging and image processing. The research project should result in a PhD
candidate: thesis.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score)OR
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisors: Dr. Frank Gijsen and Dr. Lambert Speelman
informatio E-mail: f.gijsen@erasmusmc.nl, l.speelman@erasmusmc.nl
Prof.Dr.Ir. Ton van der Steen, PhD, FESC, Professor;
n:
E-mail: a.vandersteen@erasmusmc.nl
http://www.erasmusmc.nl/thoraxcenterbme/Current-Research/BML/
Biomedical Engineering is part of the Thoraxcenter of the Erasmus Medical Center in Rotterdam,
The Netherlands. The research group led by prof.dr.ir. A. F. W. van der Steen, and is located at
the Medical Faculty of the Erasmus University. The group focuses on the origin, diagnosis and
treatment of cardiovascular diseases by bringing together two technical specialties of the
Thoraxcenter, being experimental echocardiography and bioimechanics.
List of recent publications:
Gijsen, F.J.H., et al., A new imaging technique to study 3-D plaque and shear stress distribution in
human coronary artery bifurcations in vivo. Journal of Biomechanics, 2007. 40(11): p. 2349-2357.
Groen, H.C., et al., Plaque rupture in the carotid artery is localized at the high shear stress region: A
case report. Stroke, 2007. 38(8): p. 2379-2381.
Cheng, C., et al., Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovascular
Research, 2008. 78(1): p. 123-129.
Gijsen, F.J.H., et al., Simulation of stent deployment in a realistic human coronary artery. BioMedical
Engineering Online, 2008. 7.
Gijsen, F.J.H., et al., Strain distribution over plaques in human coronary arteries relates to shear
stress. American Journal of Physiology - Heart and Circulatory Physiology, 2008. 295(4): p.
H1608-H1614.
Schuurbiers, J.C.H., et al., In vivo validation of CAAS QCA-3D coronary reconstruction using fusion of
angiography
and
intravascular
ultrasound
(ANGUS).
Catheterization
and
Cardiovascular
Interventions, 2009. 73(5): p. 620-626.
van der Giessen, A.G., et al., Plaque and shear stress distribution in human coronary bifurcations: a
multislice computed tomography study. EuroIntervention : journal of EuroPCR in collaboration with
the Working Group on Interventional Cardiology of the European Society of Cardiology, 2009. 4(5): p.
654-661.
Groen, H.C., et al., MRI-based quantification of outflow boundary conditions for computational fluid
dynamics of stenosed human carotid arteries. Journal of Biomechanics, 2010. 43(12): p. 2332-2338.
Groen, H.C., et al., Three-dimensional registration of histology of human atherosclerotic carotid
plaques to in-vivo imaging. Journal of Biomechanics, 2010. 43(11): p. 2087-2092.
van der Giessen, A.G., et al., Reproducibility, accuracy, and predictors of accuracy for the detection of
coronary atherosclerotic plaque composition by computed tomography: An ex vivo comparison to
intravascular ultrasound. Investigative Radiology, 2010. 45(11): p. 693-701.
Gijsen, F.J.H., et al., High shear stress induces a strain increase in human coronary plaques over a
6-month period. Accepted for publication in EuroIntervention, 2010.
Akyildiz, A.C., et al., Effects of intima stiffness and plaque morphology on peak cap stress.
BioMedical Engineering Online, 2011. 10.
Speelman, L., et al., Initial stress in biomechanical models of atherosclerotic plaques. J Biomech.
44(13): p. 2376-82, 2011.
Papadopoulou, S.L., et al., Detection and quantification of coronary atherosclerotic plaque by 64-slice
multidetector
CT:
A systematic
head-to-head
comparison
with
intravascular
ultrasound.
Atherosclerosis, 2011.
van der Giessen, A.G., et al., The influence of boundary conditions on wall shear stress distribution in
patients specific coronary trees. J Biomech. 44(6): p. 1089-95, 2011.
Dr. Heleen van Beusekom
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Experimental Cardiology
Thorax Center
Department of Biomedical Engineering
Project
Title:
Abstract:
The Netherlands
Imaging the pathophysiological response to coronary interventions; an experimental and
computational approach
Atherosclerosis is a major health care burden, responsible for nearly 40% mortality in the western
world. Atherosclerotic coronary artery disease, often complicated by (athero)thrombosis leading to
acute myocardial infarction constitutes a dominant part of this problem. Percutaneous Coronary
Intervention (PCI) by implantation of a drug eluting stent (DES) is currently the treatment of choice
for acute coronary syndromes as well as stable angina.
In this project we will study the relation between the vascular environment (structures such as
atheromatous plaque, fibrous intimal thickening, coronary thrombus), local and distal vascular drug
uptake, vascular healing and microvascular function following DES placement. To this end, we will
apply a combination of in vivo imaging in an animal model for coronary atherosclerosis, ex vivo
molecular histology by means of imaging mass spectrometry (IMS), and numerical modeling of drug
transport in the vascular bed.
Until now limited information is available on the concentration distribution of drugs and drug vehicles
along the vessel lumen and inside the atherosclerotic vessel wall. Convection and diffusion of
molecules into the blood and wall largely depends on their size, charge, and whether the compound is
lipophilic or hydrophilic. We will image the pathophysiological response of the coronary circulation to
the intervention by means of several intravascular imaging techniques, and match that diagnostic
information to the molecular histology, studying pharmacokinetics, drug metabolites, and plaque
lipidomics. A numerical model will be developed and validated based on these data, to compute the
distribution of compounds with different molecular sizes at the lumen and in the vessel wall using
realistic 3D reconstructions of lumen and wall of coronary arteries. At the end of this project, we will
have created a tool to predict the vascular response to DES placement in patients, based on diagnostic
imaging and patient-specific modeling.
Requirem
ents
of
candidate:
Background: A solid knowledge of biochemistry or mass spectrometry, and should have a background
in Chemistry, Biology, or Physics, with a keen interest in Medicine, particularly cardiology.
Master degree: yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Other: In the context of the Rotterdam-China exchange program, sponsored by EUR and CSC, we are
currently looking for two candidates who are interested to join our lab for a 4 year PhD program.
Candidate 1 must have a solid knowledge of biochemistry or mass spectrometry, and should have a
background in Chemistry, Biology, or Physics; candidate 2 must have a solid knowledge of Biomedical
Engineering, with affinity for finite element modeling and/or experimental studies.
Both should have a keen interest in Medicine, particularly cardiology, good command of English
(written and oral) and have recently received, or will receive in the coming months, an MSc degree in
a suitable field.
Supervisor
informatio
n:
Supervisor: Heleen van Beusekom, PhD
Senior Scientist; h.vanbeusekom@erasmusmc.nl
Department of Experimental Cardiology
Co- Supervisors: Gijs van Soest, PhD, Assistant Professor;
E-mail: g.vansoest@erasmusmc.nl
J.J. Wentzel , PhD Associate Professor;
E-mail j.wentzel@erasmusmc.nl
Ton van der Steen, PhD, FESC, Professor;
E-mail: a.vandersteen@erasmusmc.nl
Department of Biomedical Engineering
Thorax Center
Erasmus MC
PO Box 2040
3000 CA Rotterdam
The Netherlands
Relevant publication list; all supervisors:
1. Wentzel JJ, et al., Stent implantation in coronary arteries causes alterations in 3-D geometry and
distribution of 3-D shear stress at the endothelium. Journal of Biomechanics, 2000,
33:10:1287-1295.
2. Slager CJ, et al. True 3-D Reconstruction of Coronary Arteries in Patients by fusion of
Angiography and IVUS (ANGUS) and its Quantitative Validation. Circulation, 2000, 102:
511-516.
3. Wentzel JJ,
et al. The relationship between neointimal thickness and shear stress after Wallstent
implantation in human coronary arteries at 6 months follow up. Circulation, 2000, 102: 1740-1745.
4. Thury A,
et al. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress?
Circulation, 2002, Jun 11;105(23):e185-7.
5. Wentzel JJ, et al. Shear stress, vascular remodeling and neointimal formation. J Biomech., 2003,
May;36(5):681-8.
6. Gijsen FJH, et al. Tissue regression in sirolimus-eluting stents in human coronary arteries is
localized and correlates with shear stress. Am J Cardiol., 2003, Dec 1;92(11):1325-8.
7. ten Have AG, et al. Temperature distribution in atherosclerotic coronary arteries: influence of
plaque geometry and flow (a numerical study). Phys Med Biol., 2004, Oct 7;49(19):4447-62.
8. Slager CJ, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat
Clin Pract Cardiovasc Med., 2005, Aug;2(8):401-7.
10. Slager CJ, et al. The role of shear stress in destabilization of vulnerable plaques and related
therapeutic implications. Nat Clin Pract Cardiovasc., 2005, Sept;2(9):456-64.
11. ten Have A, et al. Intracoronary thermography: Heat generation, transfer and detection,
EuroIntervention 1(1); May 2005: 105-114
12. Ten Have AG, et al. Influence of catheter design on lumen wall temperature distribution in
intracoronary thermography. J Biomech. 2007;40(2):281-8.
13. Ten Have AG, et al. A numerical study on the influence of vulnerable plaque composition on
intravascular thermography measurements. Phys Med Biol. 2006 Nov 21;51(22):5875-87.
14. Wentzel JJ,
et al. In vivo 3D distribution of lipid-core plaque in human coronary artery as
assessed by fusion of near infrared spectroscopy-intravascular ultrasound and multislice computed
tomography scan.Circ Cardiovasc Imaging. 2010 Nov 1;3(6):e6-7.
15. Commandeur S, et al. Polymers, drug release, and drug-eluting stents. J Interv Cardiol. 2006
Dec;19(6):500-6. Review
16. van Beusekom HM, et al.
Drug-eluting stents show delayed healing: paclitaxel more pronounced
than sirolimus. Eur Heart J. 2007 Apr;28(8):974-9.
17. van Beusekom et al. The neointimal response to stents eluting tacrolimus from a degradable
coating depends on the balance between polymer degradation and drug release.
EuroIntervention.
2008 May;4(1):139-47.
18. Onuma Y, et al The paradigm of endothelium and stent thrombosis in DES. EuroIntervention. 2008
Aug;4 Suppl C:C17-21.
19. Ertaş G, van Beusekom HM, van der Giessen WJ. Late stent thrombosis, endothelialisation and
drug-eluting stents. Neth Heart J. 2009 Apr;17(4):177-80.
20. van den Heuvel M, et al. Endothelial dysfunction after drug eluting stent implantation. Minerva
Cardioangiol. 2009 Oct;57(5):629-43. Review.
21. van Beusekom HM, et al. Endothelial function rather than endothelial restoration is altered in
paclitaxel- as compared to bare metal-, sirolimusand tacrolimus-eluting stents. EuroIntervention.
2010 May;6(1):117-25. doi: 10.4244/.
22. van den Heuvel M, et al.
Specific coronary drug-eluting stents interfere with distal microvascular
function after single stent implantation in pigs. JACC Cardiovasc Interv. 2010 Jul;3(7):723-30.
Erratum in: JACC Cardiovasc Interv. 2010 Sep;3(9):994.
23. Van Der Giessen WJ, Van Beusekom HM. New drug-eluting stents with biodegradable polymers.
Minerva Cardioangiol. 2011 Feb;59(1):31-8.
24. Gonzalo N, et al. Optical coherence tomography patterns of stent restenosis. Am Heart J.
2009;158(2):284-293.
25. van Soest G, et al. Atherosclerotic tissue characterization in vivo by optical coherence tomography
attenuation imaging. J Biomed Opt. 2010;15(1):011105-011109.
26. Goderie TPM, et al. Combined optical coherence tomography and intravascular ultrasound radio
frequency data analysis for plaque characterization. Classification accuracy of human coronary
plaques in vitro. International Journal Of Cardiovascular Imaging. 2010;26(8):843-850.
27. Garg S, et al. First use in patients of a combined near infra-red spectroscopy and intra-vascular
ultrasound catheter to identify composition and structure of coronary plaque. EuroIntervention.
2010;5(6):755-756.
28. Regar E, et al. Optical coherence tomography in patients with acute coronary syndrome.
EuroIntervention. 2010;6 Suppl G:G154-160.
29. Gonzalo N, et al. Witnessed Coronary Plaque Rupture During Cardiac Catheterization. JACC
Cardiovasc Imaging. 2011;4(4):437-438.
30. Regar E, et al. The diagnostic value of intracoronary optical coherence tomography. Herz.
2011;36(5):417-429.
31. van Soest G, et al. Pitfalls in Plaque Characterization by OCT: Image Artifacts in Native Coronary
Arteries. J Am Coll Cardiol Img. 2011;4(7):810-813.
32. Jansen K, et al. Intravascular photoacoustic imaging of human coronary atherosclerosis. Opt. Lett.
2011;36(5):597-599.
Dr. Helleman
School/De
partment:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
The Netherlands
Department Medical Oncology
Can Ascites Tumor cells aid in improving treatment decision and monitoring ovarian cancer
patients?
Epithelial ovarian cancer is the most lethal malignancy among gynecological cancers in the
Western World. Most patients are diagnosed with disease already spread outside the pelvis.
Nowadays these patients often receive standard platinum-based chemotherapy prior to
surgery (neo-adjuvant) to facilitate a more complete removal of the tumor resulting in an
improved overall survival.
Within this project we will investigate whether Ascites Tumor Cells (ATCs) isolated from
ascites by FACS-sorting are of diagnostic and predictive use. The use of ATCs may be
preferred to tumor tissue since ascites punctions are less invasive than obtaining tumor tissue
through surgery or biopsy. In addition, ascites contains a high number of tumor cells which is
not always true for biopsies. Furthermore, the Single Nucleotide Polymorphism (SNP) profile
(~300.000 markers measured with HumanCytoSNP-12, Illumina) of the primary tumor and
ATCs show a similar pattern of copy number variations, indicating that the FACS-sorted and
EpCAM positive cells from the ascites are indeed tumor cells.
Objectives of this project improving treatment decision for ovarian cancer are:
- to confirm that FACS sorted EpCAM expressing cells from ascites originate from the
primary tumor (by comparison of the SNP profiles).
- to culture the ATCs (for a subset of the patients) and determine drug response to individual
drugs (by cell culture & drug response assays)
-to validate in house developed response prediction signatures in the ATCs (by gene &
microRNA expression analysis and pathway analysis)
-to develop models for response monitoring during therapy in the ATCs (by gene expression
analysis & SNP analysis)
Techniques used are FACS sorting, cryo-sectioning of tissues, SNParray, gene expression
profiling, qRT-PCR, cell culture, drug response assay, pathway analyses.
This project fits excellent within our current research that focuses on developing molecular
models that can predict response to (novel) individual drugs resulting in more treatment
options. These models are based on the molecular characteristics of the primary (untreated)
tumor. For this we used our extremely well characterized collection of 40 ovarian cancer cell
lines as well as clinical samples, see department website (Workgroup Integrated genomics of
treatment
resistance):
http://www.erasmusmc.nl/interne_oncologie/research/ResearchPrograms/cancer_genomics_a
nd_proteomics/?lang=en
Requirem Background: Molecular Biology
ents
of Master degree: Yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score)Or
TOEFL: 100 (min. 20 per sub-score)
Other: Interview (by phone) is mandatory
Supervisor Supervisor: Dr. J. Helleman E-mail: j.helleman@erasmusmc.nl
informatio Publication list:
n:
1. Microarray-based oncogenic pathway profiling in advanced serous papillary ovarian
carcinoma. X,B, Trinh, W.A. Tjalma, L.Y. Dirix, P.B. Vermeulen, D.J. Peeters, D.
Bachvarov, M. Plante, E.M.J.J.Berns, J. Helleman, S.J. Van Laere, P.A. van Dam.
PLoS One. 2011;6(7):e22469.
2. MicroRNAs in ovarian cancer biology and therapy resistance. M.T.M. van Jaarsveld,
J. Helleman, E.M.J.J. Berns and E.A.C. Wiemer. The International Journal of
Biochemistry & Cell Biology 2010 J.18
3. Pathway analysis of gene lists associated with platinum-based chemotherapy
resistance in ovarian cancer: The big picture. J. Helleman, M. Smid, M.P.H.M.
Jansen, M.E.L. van der Burg, E.M.J.J. Berns. Gynecol Oncol 2010 Feb 3
4. Differential transport of platinum compounds by the human organic cation
transporter hOCT2 (hSLC22A2). H. Burger, A. Zoumaro-Djayoon, A.W. Boersma, J.
Helleman, E.M.J.J. Berns, R.H. Mathijssen, W.J. Loos, E.A.C. Wiemer. Br J
5.
6.
7.
8.
9.
Pharmacol. 2010 J.8.
Integrated genomics of chemotherapy resistant ovarian cancer: a role for
extracellular matrix, TGFbeta and regulating microRNAs. J. Helleman, M. P.H.M.
Jansen, C. Burger, M.E.L. van der Burg, E.M.J.J. Berns Int J Biochem Cell Biol.
2010 Jan;42(1):25-30. Epub 2009 Oct 23.
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human
epithelial ovarian cancer. X.B. Trinh, W.A.A. Tjalma, P.B. Vermeulen, G. Van den
Eynden, I. Van der Auwera, S.J. Van Laere, J. Helleman, E.M.J.J. Berns, L.Y. Dirix
and P.A. van Dam. Brit J Cancer. 2009;100(6):971-978
Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to
endocrine therapy in breast cancer. M.P.H.M. Jansen, K. Ritstier, L.C. Dorssers, I.L.
van Staveren, M.P. Look, M.E. Meijer-van Gelder, A.M. Sieuwerts, J. Helleman, S.
Sleijfer, J.G.M. Klijn, J.A. Foekens, E.M.J.J. Berns. Breast Cancer Treat. 2009;
116(2):263-271.
Association of extracellular matrix gene cluster with breast cancer prognosis and
response to therapy. J. Helleman, M.P.H.M. Jansen, K. Ritstier, I.L. van Staveren,
M.P. Look, M.E. Meijer-van Gelder, A.M. Sieuwerts, J.G.M. Klijn, J.A. Foekens,
E.M.J.J. Berns. Clin Cancer Res. 2008;14(17):5555-5564
Serum proteomic patterns for ovarian cancer monitoring. J. Helleman, D.
van der Vlies, M.P.H.M. Jansen, T.M. Luider, M.E.L. van der Burg, G.
Stoter and E.M.J.J. Berns. (JH and DvdV contributed equally) Int J
Gynecol Cancer 2008; 18 (5): 985-995
10. Mismatch repair and treatment resistance in ovarian cancer. J.Helleman, I.L. van
11.
12.
13.
14.
15.
Staveren, W.N.M. Dinjens, P.F. van Kuijk, K. Ritstier, P.C. Ewing, M.E.L. van der
Burg, G. Stoter and E.M.J.J. Berns. BMC Cancer 2006; 6: 201
Impaired cisplatin influx in an A2780 mutant cell line: evidence for a putative, cisconfiguration-specific, platinum influx transporter. J. Helleman, H. Burger, I.H.L.
Hamelers, A.W.M. Boersma, A.I.P.M. de Kroon, G. Stoter, K. Nooter. (JH and HB
contributed equally). Cancer Biol Ther 2006; 5(8): 943-949
Gene expression profiling of treatment resistance: hype or hope for therapeutic target
identification. J. Helleman, M.P.H.M.Jansen, E.M.J.J. Berns. Int J Gynecol Cancer
2006; 16 (Suppl. 2): 538-542
Molecular profiling of platinum resistant ovarian cancer. J. Helleman, M.P.H.M.
Jansen, P.N. Span, I.L. van Staveren, L.F.A.G. Massuger, M.E. Meijer-van Gelder,
F.C.G.J. Sweep, P.C. Ewing, M.E.L. van der Burg, G. Stoter, K. Nooter and E.M.J.J.
Berns Int J Cancer 2006 April 15; 118(7):1963-1971

In reply to the letter to the editor. J. Helleman, M.P.H.M. Jansen, M.E.L. van der
Burg, and E.M.J.J. Berns Int J Cancer 2006 September 15; 119(6):1512
Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine
toxicity.
J. Bierau, A.H. van Gennip, R. Leen, J. Helleman, H.N. Caron, A.B. van Kuilenburg.
Int J Cancer 2003 J.20;103(3):387-92.
The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on
neuroblastoma cell lines. J. Bierau, A.H. van Gennip, J. Helleman, A.B. van
Kuilenburg. Biochem Pharmacol 2001 Oct 15;62(8):1099-105
Dr. Henri Braat
School/De
partment:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
Department of Gastroenterology & Hepatology
The Netherlands
Pancreatic cancer, a novel endoscopic and translational approach to treat a complex disease.
Purpose:
Pancreatic cancer has the worst prognosis of all gastro-intestinal cancers, the 5-year overall
survival is less then 5%. Late detection, early metastasis, difficult surgery and inefficient medical
treatment all contribute to its infaust prognosis. Pancreatic cancer is characterized by extensive
extra-cellular matrix depositions suggesting a role for the microenvironment in tumour biology.
With the present application, the applicant hopes to develop a novel translational gastro-intestinal
research line concerning pancreatic cancer. Special attention will be paid to the identification of
novel biomarkers for cystic pancreatic lesions and microenvironmental factors in pancreatic
cancer development.
Specific hypothesis:
1. Cystic fluid can be utilized to provide information regarding the malignant potential of cystic
lesions by identifying novel biomarkers, micro-RNA in particular.
2. Hedgehog signal transduction and epigenetic changes in pancreatic mesenchymal cells drive
pancreatic cancer progression.
Objectives:
1. To identify novel biomarkers in cystic fluid in order to improve clinical decision making
regarding surgical therapy of pancreatic cystic lesions.
2. Phenotypic characterization and sorting of distinct cell populations within pancreatic tumors.
3. To identify mechanisms employed by pancreatic mesenchymal cells which promote pancreatic
cancer progression and to identify novel therapies intervening with mesenchymal cell function.
Plan of investigation:
Most studies on pancreatic cancer are performed on a limited number of cell lines, which can
grow without mesenchymal support, or post-mortem
/resection specimens of which it is uncertain to which extent they actually fairly represent early
disease. With the continuing development of endoscopic technology novel applications to perform
tissue acquisition and local therapy have become available. Endoscopic ultrasound has become
the cornerstone in the diagnostic work-up of pancreatic disease and it has become possible to
obtain tissue material for experimental and diagnostic purposes. I propose to collect Fine Needle
Aspirate/Biopsy taken from patients with cystic- and solid pancreatic lesions for the identification
of biomarkers and culture of stromal cells. Some pancreatic cysts are benign in origin but can
develop into cancer. Currently we lack adequate biomarkers which can estimate the malignant
potential of cystic lesions at initial presentation resulting in unnecessary surgical intervention in a
number of cases. We have preliminary data showing that micro-RNA is present in cystic fluid and
we propose to perform micro-RNA analysis of cystic fluid in order to identify possible novel
biomarkers. Already we have a large amount of cystic fluid samples derived from a well described
clinical prospective cohort at our disposal. Patients in this cohort have a wide range of different
cystic lesions and some of these patients have undergone surgery so definite tissue diagnosis is
present. Secondly, we will obtain tissue from patients with pancreatic cancer and chronic
pancreatitis to culture pancreatic mesenchymal cells for epigenetic analysis and co cultures with
pancreatic cancer cells. Culturing mesenchymal cells provides me with sufficient material for
micro-
RNA profiling and DNA methylation in order to investigate the intrinsic biological role of
mesenchymal cells in pancreatic cancer progression. Co-culture experiments, while modulating
the Hedgehog-signal transduction pathway, will give us more insight how Hedgehog signaling in
mesenchymal cells reciprocally activate pancreatic cancer cells. Special attention will be paid to
apoptosis, proliferation and chemotherapy resistance of pancreatic cancer cells. Moreover,
extra-cellular matrix deposition and the production of growth- and angiogenic factors by
mesenchymal cells will be assessed.
Requireme Background: Medical student with interest in translational research in the field of
Gastroenterology.
nts
of
candidate: Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisor: Dr. H. Braat
informatio E-mail: h.braat@erasmusmc.nl
Personal website:
n:
http://nl.linkedin.com/pub/henri-braat/17/8a8/517
http://www.erasmusmc.nl/mdl/organisatie/stafmdl/2838056/
Recent publication list
1. Huibregtse IL et.al. Induction of ovalbumin-specific tolerance by oral administration of L.
lactis secreting ovalbumin. Gastroenterology 2007.
2. Braat H, et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's
disease. Clin Gastroenterol Hepatol. 2006
3. Braat H, et al. Prevention of experimental colitis by parenteral administration of a
pathogen-derived immunomodulatory molecule. Gut 2007.
Dr. J. Visser
Schol
Deprtment:
Erasmus University Medical Center Rotterdam Department of Internal Medicine
Laboratory of Reproduction and Metabolism
(Research School Molecular Medicine (www.molmed.nl))
The Netherlands
Project title
Role of ovarian growth factors in metabolic function in polycystic ovary syndrome
Abstract:
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5-10% of women in their
reproductive life. PCOS is characterized by (at least) two out of the following three criteria: oligo- or
anovulation, clinical or biochemical hyper and rogenism and polycystic ovaries on ultrasound. In
addition to the ovarian phenotype, PCOS is also associated with a metabolic phenotype. More than 50%
of PCOS patients are obese and have an abdominal distribution of body fat, which is considered a risk
factor for metabolic disease. Indeed, many PCOS patients have a level of peripheral insulin resistance
resembling women with type 2 diabetes. It is generally agreed that elevated androgens are the main
culprit of the syndrome, affecting both ovarian and adipose tissue function. Recently, we have
developed an androgen-induced mouse model for PCOS, which shows both the reproductive and
metabolic phenotypes of PCOS. This model allows us to investigate the interaction between ovarian
function and metabolism. The aim of this project is to study the role of ovarian growth factors on
metabolic function. For this purpose anti-Müllerian hormone (AMH)-deficient mice will be treated with
androgens to induce PCOS. We have shown that AMH-deficient mice have a threefold increased
number of growing follicles due to increased primordial follicle recruitment. Due to the increased
number of growing follicles, AMH-deficient mice have elevated serum levels of ovarian growth factors.
This allows us to investigate the contributing effect of these growth factors, in addition to androgens, on
adipose tissue function. Since, increased obesity can worsen the PCOS phenotype, we will also study
the effect of high-fat diet on ovarian and metabolic function in this PCOS model. These
androgen-treated AMH-deficient mice, either on a normal or high-fat diet, will be analyzed for
differences in glucose and insulin sensitivity, and other metabolic parameters. To determine which
adipose depot contributes mostly to the PCOS phenotype, various adipose depots will be isolated for
analysis of gene and miRNA expression. Our preliminarily results suggest that specifically changes in
adipokines differ between depots. As a second part of the project, we will analyze the effect of
androgens, with or without growth factors, on differentiation and function of adipocytes in vitro. For
this purpose we will isolate the stromal vascular fraction (SVF) from adipose depots. The SVF contain
the preadipocytes that can be differentiated in vitro into mature adipocytes. The in vitro culture allows
us to determine whether the change in adipocyte function by androgens and growth factors is due to a
direct effect on the mature adipocyte or due to a reprogramming effect during differentiation.
Knowledge about the effect of androgens and ovarian growth factors on adipose tissue may help to
understand the metabolic changes in PCOS.
Keywords: PCOS, ovarian function, metabolism, adipose tissue.
Requi
reme
nts of
candi
date:
Background: Molecular Biology, preferably with knowledge of Physiology
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Other: Affinity or experience with laboratory animal experiments. Candidate must follow a 3-week
course in laboratory animal science and pass the subsequent exam in order to obtain permission to work
with laboratory animals.
Supervisor
information:
Supervisor: Prof. dr. ir. Axel P.N. Themmen
E-mail: a.themmen@erasmusmc.nl
Recent publication list:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Themmen%20AP%22[Author]
Co-supervisor: Dr.ir. Jenny A. Visser E-mail: j.visser@erasmusmc.nl
Research interests: - Role of TGFβ family members in ovarian function
- Interaction between ovarian function and metabolism
Recent publication list:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Visser%20JA%22[Author]%20not%20%22de%20Viss
er%20JA%22
Dr. John Hays
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Medical Microbiology & Infectious Diseases
Project Title:
Abstract:
Determining the Effect of Antimicrobial Therapy on the Human Microbiome.
Scientists have only just started to characterize the human microbiome (the total
population of bacteria present on, and in, humans), and the effect that changes in human
microbiome can have on human health and disease. Efforts to characterize the human
microbiome in the past have been hindered by the large number of bacterial species present in
the human microbiome, coupled to the fact that many of these organisms are "unculturable"
using standard laboratory techniques. However, new technological developments e.g. the use of
a high-throughput amplicon sequencing, is now allowing the human microbiome to be
accurately mapped and characterized, such that the effect of human microbiome changes on
health and disease can now be determined.
Antibiotics are frequently used in the hospital environment, in the community, and in
animals, usually to fight infection or to promote animal growth. However, the unrestricted use
of antibiotics has led to an alarming increase in antimicrobial resistance worldwide, with the
use of antibiotics acting to promote the growth of pathogenic (antimicrobial resistant)
microorganisms during antimicrobial therapy. In effect, the antimicrobial resistant organisms
are able to fill the environmental niches left over by the destruction of the normal human
microflora.
In this research project, the student will investigate the effect of antimicrobial therapy on
the composition of the human microbiome. Comparisons will be made before, during and after
antimicrobial therapy, using sick and healthy patient populations. Target populations currently
include neonates suffering from cystic fibrosis, and stroke patients, and we are particularly
interested in the effect of prophylactic antibiotics in these patient groups. Additionally, other
target population groups may be added when available (the Erasmus Medical Centre has access
to many different patient populations for study).
A mixture of traditional (culture-based) techniques and "next-generation sequencing"
techniques will be utilized to map the effect of antimicrobial therapy on the human
microbiome. Further, molecular biology techniques e.g. PCR, gene cloning etc, will be used to
further investigate the mechanisms of any antimicrobial resistances found. The results will be
utilized to identify human microbiome combinations that provide an indication of the
likelihood of the development of antimicrobial resistance during antimicrobial chemotherapy.
Results will also be used to determine if the composition of the human microbiome may be
utilized to provide a prognosis of the future health of various patient populations in the hospital
environment.
References
o Blaser et al. Antibiotic overuse: Stop the killing of beneficial bacteria. 2011 Nature.
476:393–394
o Wu et al. Sampling and pyrosequencing methods for characterizing bacterial communities
in the human gut using 16S sequence tags. BMC Microbiology. 2010. 10:206-219.
The Netherlands
Requireme Background:
- The candidate should possess knowledge and/or training in
nts
of
medical microbiology and be interested in bioinformatics.
candidate:
- Bioinformaticians with an interest in medical microbiology are also encouraged to apply.
Master degree: Yes
Supervisor
informatio
n:
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor: Dr. J. Hays, Dept. Medical Microbiology & Infectious Diseases, Erasmus MC
E-mail : j.hays@erasmusmc.nl
Web: http://www.researchgate.net/profile/John_Hays/
Co-supervisor: Dr. W. Goessens, Dept. Medical Microbiology & Infectious Diseases, Erasmus
MC
E-mail : w.goessens@erasmusmc.nl
Co-supervisor: Dr. M. van Westreenen, Dept. Medical Microbiology &
Infectious Diseases, Erasmus MC E-mail : m.vanwestreenen@erasmusmc.nl
Dr. Kok
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Urology The Netherlands
Project Title:
Bacterial populations and human-bacterial interactions in urinary tract infection.
Abstract:
Bacterial pathogenic properties and interactions between bacteria and the host are recognized to
play a role in acquiring and fighting off infectious diseases. The role of bacterial population
dynamics is becoming recognized. In this new research field we have thus far shown that the
composition of bacterial populations is predictive for development of future urinary tract
infection. In our ongoing research we investigate bacterial population composition in urine
samples with 16S rDNA analysis and protein markers for mechanisms of bacterial survival and
the host response with a variety of techniques. We focus on patients with a propensity for UTI
and matching controls and relate the urine data to diagnosis (urinary tract function, urine
culture results) and prognosis (of new UTI).
The project combines basic research with direct clinical application.
Requirem Background: Microbiology
ents
of Master degree: Yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
GMAT/GRE: 640
Supervisor
informatio
n:
School/De
partment:
Supervisor: Ass. Prof. D.J. Kok E-mail: d.kok@erasmusmc.nl
Website: http://www.niersteen.com/page9.php
Project Title:
Lifestyle intervention with internet based tools
Abstract:
Life style advice forms an integral part of treatment and prevention for many diseases. We
focus on urinary stone formation. Very often interventions that prove to have significant
desired effect on when tested under controlled study conditions have disappointingly small
effect in general practice. A main reason for this is that in the general application compliance to
the intervention is low. In the controlled studies a better compliance is obtained at the cost of
Erasmus University Medical Center Rotterdam
Department of Urology
The Netherlands
time intensive support by the health professional. The low compliance stems from lack of
continuing information on the patient side about purpose and details of the intervention,
problems to translate the information to the individual situation and lack of motivation.
Our goal is to take the success of lifestyle intervention in its general application to the same
level as can be obtained in controlled studies. For this we have developed an internet based
approach where patients are informed about the ins and outs of the lifestyle intervention and
that provides tools that allow the patient to calculate how their actual lifestyle compares to the
advised one and that generate detailed individual advice on how to improve the lifestyle. (see
www.niersteen.com)
In this project we want to test this approach on urinary stone formers of various cultural and
geographical backgrounds. For that the internet tools will be translated to the different lifestyle
habits and languages and tested in multiple countries.
Iinternet tools are also used by us to assist MM C patients with their catheterization/
medication advice www.blaasdruk.nl) and women who are/ want to become pregnant.
Requirem Background: Medicine
ents
of Master degree: Yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
GMAT/GRE: 640
Other: computer programming skills
Supervisor Supervisor: Ass. Prof. D.J. Kok
informatio E-mail: d.kok@erasmusmc.nl
Website: http://www.niersteen.com/page9.php
n:
Dr. Marleen de Bruijne1
School/De
partment:
Erasmus University Medical Center Rotterdam
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl
The Netherlands
Project Title:
MR brain image analysis
Abstract:
MR images of the brain reveal evidence of neurological disorders already before clinical
symptoms appear. For instance, some brain structures are slightly smaller in people who will
develop dementia later on. Such image based markers are of enormous importance for early
diagnosis and may lead to improved treatment in an early stage. Erasmus MC performs a large
scale image based study of the aging brain to investigate the complex neurodegenerative patterns
involved in the development of dementia as well as in normal aging. Within this study,
multi-sequence MR brain data of approximately 5500 participants is collected at intervals of three
years. In addition, a large set of multimodal brain scans of young children is currently collected to
study factors determining brain development. In this PhD project you will develop model based
segmentation techniques to automatically analyze brain structures and lesions in these databases,
and you will use machine learning techniques to derive image markers, related to the shape, size,
and appearance of brain structures, that can help in recognizing different disorders such as
Alzheimer's disease. We suggest the following topics to work on within this PhD project, but you
are welcome to define related topics yourself in your proposal.
1. Automatic detection of microbleeds
• Microbleeds are small bleedings in the brain which are associated with a higher risk on
brain disorders and which are visible as dark spots on some MR sequences (Fig 1). A dataset
of several hundreds of MR scans with manually annotated microbleeds is available to
develop, train, and evaluate a computer aided detection system. The successful microbleed
detection system will be applied in epidemiological studies as well as in the dementia clinic.
2. Segmentation of brain structures
• Several studies measuring e.g. the volume of different brain structures have relied on
manual segmentations (Fig 2), but large scale studies require automated analysis. We have
previously developed a technique for automatic segmentation of one of the brain structures,
the hippocampus (Fig 3). This technique should be extended to cope with multiple different
structures.
3. Shape analysis of brain structures
• We have already developed and evaluated methods for hippocampus shape analysis (Fig 4),
which were shown to detect dementia in an earlier stage than does hippocampal volume.
Techniques to simultaneously analyze a number of structures need to be developed.
4. Changes over time
• We will use image registration to accurately measure changes as a result of disease
progression, aging, or growth, based on scans taken from the same person at different points
in time. Techniques used in this project: Image segmentation, pattern recognition, image
registration.
(all Figures are not available in this document)
Requireme Background: You should have a Master's degree in Physics, Electrical Engineering, Mathematics,
nts
of Biomedical Engineering, Computer Science, or a related field. Experience with biomedical image
candidate: analysis and/or machine learning is an advantage. You should be familiar with programming. You
should be able to work in a multi-disciplinary team. Strong theoretical skills and affinity with
experimental work are required.
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Dr. Marleen de Bruijne
informatio E-mail: marleen.debruijne@erasmusmc.nl
Marleen de Bruijne is an associate professor in medical image analysis both at the Erasmus MC,
n:
Rotterdam, The Netherlands and at the Department of Computer Science, University of
Copenhagen, Denmark. She leads the "Model-based Medical Image Analysis" research group in
which she develops novel techniques for quantitative analysis of medical images, with a focus on
large scale image-based studies. Her research interests include shape analysis, model based
segmentation, and pattern recognition approaches in a variety of applications. Dr. de Bruijne
(co)authored 85 peer-reviewed full papers in international conference proceedings and journals
and 17 patent applications (2 granted) and co-edited 4 books. She currently supervises 6 PhD
students 2 postdocs and has (co)supervised 6 PhD students who graduated in the last 5 years. She
is a member of the Program Committee of over 25 international conferences including the two
primary conferences in the field - SPIE Medical Imaging and MICCAI. She is also an editorial
board member of Medical Image Analysis.
An extended CV and publication list are available from http://image.diku.dk/marleen/
Dr. Marleen de Bruijne 2
School/De
partment:
Erasmus University Medical Center Rotterdam
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl
The Netherlands
Project Title:
Computer aided diagnosis of lung diseases from CT imaging
Abstract:
Accurate and reproducible quantification of abnormalities in lung images is crucial to
improve our understanding of the factors involved in development and progression of
lung diseases, to assess the effect of treatment, and to recognize problems as early as
possible and determine prognosis in individual patients. For this, automated image
analysis is required, which is especially challenging in lung images because of the
large deformations that occur during breathing.
Pulmonary image analysis at BIGR focuses on measuring structural lung damage in
patients with cystic fibrosis (CF) - both in very early and in advanced stages - and on
quantifying chronic obstructive pulmonary disease (smoker's lung, COPD) from CT
images.
We suggest the following topics to work on within this PhD project, but you may also
define related topics yourself.
1. Analysis of the airways
• Untreated lung disease can lead to irreversible damage to the airways, which can be
seen e.g. as a widening of the airway lumen or thickening of the wall. To detect this
in an early stage, segmentation of the airways and of the neighboring vessels is
needed. Some approaches exist, but these are not able to segment the smaller airways
and should therefore be improved (Fig 1).
2. Segmenting areas with trapped air
• Air trapping, where parts of the air in the lung cannot be exhaled properly, is a sign
of airway obstruction (Fig 2). We would like to measure the size and shapes of
regions of trapped air, and investigate how they change over time.
3. Texture classification
• Different lung abnormalities show a distinctive texture in the image (Fig3).
Classifying the different textures can be used to detect and quantify lung disease.
4. Changes over time
• To detect the onset or progression of lung disease, we should be able to measure any
changes in e.g. airways, trapped air, and lung texture. Robust image registration
methods need to be developed.
5. CT versus MRI
• Currently, CT is the most sensitive method to detect lung abnormalities. However,
because of the radiation applied in CT imaging MRI is sometimes preferred,
especially in dynamic imaging, in young children, or if a patient should be imaged
frequently. At Erasmus MC we therefore investigate lung MRI as a safe alternative to
lung CT. We followed a group of patients with both CT and MRI, which provides a
perfect database to develop algorithms for analysis of lung MRI and to investigate the
value of MRI compared to CT.
Techniques used in this project: Image segmentation, pattern recognition, image
registration. (all Figures are not available in this document)
Requireme Background: You should have a Master's degree in physics, electrical engineering, mathematics,
nts
of biomedical engineering, computer science, or a related field. Experience with biomedical image
candidate: analysis and/or machine learning is an advantage. You should be familiar with programming. You
should be able to work in a multi-disciplinary team. Strong theoretical skills and affinity with
experimental work are required.
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Supervisor: Dr. Marleen de Bruijne E-mail: marleen.debruijne@erasmusmc.nl
informatio Marleen de Bruijne is an associate professor in medical image analysis both at the Erasmus MC,
Rotterdam, The Netherlands and at the Department of Computer Science, University of
n:
Copenhagen, Denmark. She leads the "Model-based Medical Image Analysis" research group in
which she develops novel techniques for quantitative analysis of medical images, with a focus on
large scale image-based studies. Her research interests include shape analysis, model based
segmentation, and pattern recognition approaches in a variety of applications.
Dr. de Bruijne (co)authored 85 peer-reviewed full papers in international conference proceedings
and journals and 17 patent applications (2 granted) and co-edited 4 books. She currently
supervises 6 PhD students 2 postdocs and has (co)supervised 6 PhD students who graduated in the
last 5 years. She is a member of the Program Committee of over 25 international conferences
including the two primary conferences in the field - SPIE Medical Imaging and MICCAI. She is
also an editorial board member of Medical Image Analysis.
An extended CV and publication list are available from http://image.diku.dk/marleen/
Dr. Mischa Hoogeman
School/
Department:
Erasmus University Medical Center - Daniel den Hoed Cancer Center
Department of Radiation Oncology
School Molecular Medicine (www.molmed.nl) The Netherlands
Project Title:
Computer Aided Plan Selection for Online Adaptive Radiotherapy
Abstract:
Online Adaptive Radiotherapy (OART) is an advanced type of image-guided radiotherapy.
It uses three and four-dimensional imaging data of the tumor and surrounding tissue,
which is acquired just prior to the delivery of the radiation, to select the best fitting
treatment plan from a library of plans. The complexity of the patient anatomy and the
complexity of the treatment plans require computer assistance in the selection procedure.
One of the research lines of our department is the development of Computer Aided Plan
Selection (CAPS) strategies. CAPS breaks down into two components, i.e. fast and robust
segmentation of the relevant patient anatomy and accurate plan selection based on often
sparse information. This research will focus on the development of segmentation
techniques for CAPS for cervical and prostate cancer, and for tumors in the liver. The
segmentation techniques will be primarily knowledge-based, i.e. atlas-based and/or using
active shape and appearance models. The techniques will be applied and evaluated on
Computer Tomography (CT) and Cone Beam CT image data of clinical patients.
Algorithm development will take place in our in-house developed software platform for
image and geometry processing.
Requirements
candidate:
of
Background: Creative researcher with experience in software development (Matlab,
Python, C++), preferably in the field of medical image or geometry processing.
Master degree: Yes, Computer Science, Physics, or Applied Mathematics
IELTS Grade: at least 7.0 on average (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information:
Supervisor: Assoc. Prof. dr. Mischa S. Hoogeman (Medical Physicist, PhD)
E-mail: m.hoogeman@erasmusmc.nl
Erasmus MC - Daniel den Hoed Cancer Center
Department of Radiation Oncology
Groene Hilledijk 301
3075 EA Rotterdam
The Netherlands
Tel: +31 10 704 17 48, Fax: +31 10 704 10 12
Prof. dr. Ben J.M. Heijmen (Medical Physcist, PhD), Work Group Leader
E-mail: b.heijmen@erasmusmc.nl
Website: http://www.erasmusmc.nl/radiotherapie/research/radiationoncologyandphysics/
Recent publication list:
1.
Voet PW, Dirkx ML, Teguh DN, Hoogeman MS, Levendag PC, Heijmen BJ. Does atlas-based
autosegmentation of neck levels require subsequent manual contour editing to avoid risk of severe
target underdosage? A dosimetric analysis. Radiother Oncol. 2011 Mar;98(3):373-7.
2.
Vasquez Osorio EM, Hoogeman MS, Teguh DN, Al-Mamgani A, Kolkman-Deurloo IK, Bondar L, et
al. Three-dimensional dose addition of external beam radiotherapy and brachytherapy for
oropharyngeal patients using nonrigid registration. Int J Radiat Oncol Biol Phys. 2011 Jul
15;80(4):1268-77.
3.
van der Voort van Zyp NC, Hoogeman MS, van de Water S, Levendag PC, van der Holt B, Heijmen
BJ, et al. Stability of Markers Used for Real-Time Tumor Tracking After Percutaneous
Intrapulmonary Placement. Int J Radiat Oncol Biol Phys. 2011 Feb 22.
4.
van de Water S, Hoogeman MS, Breedveld S, Nuyttens JJ, Schaart DR, Heijmen BJ. Variable Circular
Collimator in Robotic Radiosurgery: A Time-Efficient Alternative to a Mini-Multileaf Collimator? Int
J Radiat Oncol Biol Phys. 2011 Mar 4.
5.
van de Water S, Hoogeman MS, Breedveld S, Heijmen BJ. Shortening treatment time in robotic
radiosurgery using a novel node reduction technique. Med Phys. 2011 Mar;38(3):1397-405.
6.
Depuydt T, Verellen D, Haas O, Gevaert T, Linthout N, Duchateau M, et al. Geometric accuracy of a
novel gimbals based radiation therapy tumor tracking system. Radiother Oncol. 2011
Mar;98(3):365-72.
7.
Budiarto E, Keijzer M, Storchi PR, Hoogeman MS, Bondar L, Mutanga TF, et al. A population-based
model to describe geometrical uncertainties in radiotherapy: applied to prostate cases. Phys Med Biol.
2011 Feb 21;56(4):1045-61.
8.
Bondar L, Hoogeman M, Mens JW, Dhawtal G, de Pree I, Ahmad R, et al. Toward an individualized
target motion management for IMRT of cervical cancer based on model-predicted cervix-uterus shape
and position. Radiother Oncol. 2011 May;99(2):240-5.
9.
Ahmad R, Hoogeman MS, Bondar M, Dhawtal V, Quint S, De Pree I, et al. Increasing treatment
accuracy for cervical cancer patients using correlations between bladder-filling change and
cervix-uterus displacements: proof of principle. Radiother Oncol. 2011 Mar;98(3):340-6.
10.
van der Voort van Zyp NC, Hoogeman MS, van de Water S, Levendag PC, van der Holt B, Heijmen
BJ, et al. Clinical introduction of Monte Carlo treatment planning: a different prescription dose for
non-small cell lung cancer according to tumor location and size. Radiother Oncol. 2010
Jul;96(1):55-60.
11.
Teguh DN, Levendag PC, Voet PW, Al-Mamgani A, Han X, Wolf TK, et al. Clinical Validation of
Atlas-Based Auto-Segmentation of Multiple Target Volumes and Normal Tissue
(Swallowing/Mastication) Structures in the Head and Neck. Int J Radiat Oncol Biol Phys. 2010 Oct 5.
12.
Mutanga TF, de Boer HC, van der Wielen GJ, Hoogeman MS, Incrocci L, Heijmen BJ. Margin
Evaluation in the Presence of Deformation, Rotation, and Translation in Prostate and Entire Seminal
Vesicle Irradiation with Daily Marker-Based Setup Corrections. Int J Radiat Oncol Biol Phys. 2010
Oct 29.
13.
Bondar L, Hoogeman MS, Vasquez Osorio EM, Heijmen BJ. A symmetric nonrigid registration
method to handle large organ deformations in cervical cancer patients. Med Phys. 2010
Jul;37(7):3760-72.
14.
Aluwini S, van Rooij P, Hoogeman M, Bangma C, Kirkels WJ, Incrocci L, et al. CyberKnife
stereotactic radiotherapy as monotherapy for low- to intermediate-stage prostate cancer: early
experience, feasibility, and tolerance. J Endourol. 2010 May;24(5):865-9.
15.
Vasquez Osorio EM, Hoogeman MS, Bondar L, Levendag PC, Heijmen BJ. A novel flexible
framework with automatic feature correspondence optimization for nonrigid registration in
radiotherapy. Med Phys. 2009 Jul;36(7):2848-59.
16.
van der Voort van Zyp NC, Prevost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al.
Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical
outcome. Radiother Oncol. 2009 Jun;91(3):296-300.
17.
Hoogeman M, Prevost JB, Nuyttens J, Poll J, Levendag P, Heijmen B. Clinical accuracy of the
respiratory tumor tracking system of the cyberknife: assessment by analysis of log files. Int J Radiat
Oncol Biol Phys. 2009 May 1;74(1):297-303.
18.
Vasquez Osorio EM, Hoogeman MS, Al-Mamgani A, Teguh DN, Levendag PC, Heijmen BJ. Local
anatomic changes in parotid and submandibular glands during radiotherapy for oropharynx cancer
and correlation with dose, studied in detail with nonrigid registration. Int J Radiat Oncol Biol Phys.
2008 Mar 1;70(3):875-82.
19.
van der Wielen GJ, Mutanga TF, Incrocci L, Kirkels WJ, Vasquez Osorio EM, Hoogeman MS, et al.
Deformation of prostate and seminal vesicles relative to intraprostatic fiducial markers. Int J Radiat
Oncol Biol Phys. 2008 Dec 1;72(5):1604-11 e3.
20.
van der Wielen GJ, Hoogeman MS, Dohle GR, van Putten WL, Incrocci L. Dose-volume parameters
of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy
for prostate cancer: results from a dose-escalation trial. Int J Radiat Oncol Biol Phys. 2008 Jul
1;71(3):795-800.
21.
Prevost JB, Voet P, Hoogeman M, Praag J, Levendag P, Nuyttens JJ. Four-dimensional stereotactic
radiotherapy for early stage non-small cell lung cancer: a comparative planning study. Technol Cancer
Res Treat. 2008 Feb;7(1):27-33.
22.
Prevost JB, Nuyttens JJ, Hoogeman MS, Poll JJ, van Dijk LC, Pattynama PM. Endovascular coils as
lung tumour markers in real-time tumour tracking stereotactic radiotherapy: preliminary results. Eur
Radiol. 2008 Aug;18(8):1569-76.
23.
Poll JJ, Hoogeman MS, Prevost JB, Nuyttens JJ, Levendag PC, Heijmen BJ. Reducing monitor units
for robotic radiosurgery by optimized use of multiple collimators. Med Phys. 2008 Jun;35(6):2294-9.
24.
Hoogeman MS, Nuyttens JJ, Levendag PC, Heijmen BJ. Time dependence of intrafraction patient
motion assessed by repeat stereoscopic imaging. Int J Radiat Oncol Biol Phys. 2008 Feb
1;70(2):609-18.
25.
Han X, Hoogeman MS, Levendag PC, Hibbard LS, Teguh DN, Voet P, et al. Atlas-based
auto-segmentation of head and neck CT images. Med Image Comput Comput Assist Interv.
2008;11(Pt 2):434-41.
26.
Ahmad R, Hoogeman MS, Quint S, Mens JW, de Pree I, Heijmen BJ. Inter-fraction bladder filling
variations and time trends for cervical cancer patients assessed with a portable 3-dimensional
ultrasound bladder scanner. Radiother Oncol. 2008 Nov;89(2):172-9.
27.
Nuyttens JJ, Prevost JB, Van der Voort van Zijp NC, Hoogeman M, Levendag PC. Curative
stereotactic robotic radiotherapy treatment for extracranial, extrapulmonary, extrahepatic, and
extraspinal tumors: technique, early results, and toxicity. Technol Cancer Res Treat. 2007
Dec;6(6):605-10.
28.
Nuver TT, Hoogeman MS, Remeijer P, van Herk M, Lebesque JV. An adaptive off-line procedure for
radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1559-67.
29.
Heemsbergen WD, Hoogeman MS, Witte MG, Peeters ST, Incrocci L, Lebesque JV. Increased risk of
biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning:
results from the Dutch trial of 68 GY versus 78 Gy. Int J Radiat Oncol Biol Phys. 2007 Apr
1;67(5):1418-24.
Dr. Reno Debets
School/
Department:
Erasmus University Medical Center Rotterdam Department of Medical Oncology
Laboratory of Experimental Tumor Immunology The Netherlands
Project
Title:
Abstract:
Immunotherapy of solid tumors: strategies to enhance tumor entry and anti-tumor activity of
antigen-specific T cells.
Despite early clinical successes of adoptive therapy with gene-engineered T cells, there is a need
to further increase the anti-tumor activity of adoptively transferred T cells. Recently, there is
accumulating evidence that the tumor microenvironment may limit the ability of cytotoxic T cells
to enter tumor tissue and render them non-responsive towards tumor cells. In fact, certain
signaling molecules and their downstream cytokines are often constitutively activated in cancer
cells and dictate a milieu that promotes tumor growth and evades T cell responses. Strategies that
inhibit such pathways would reverse a pro-inflammatory and immune evading milieu within
tumors and enable immune-mediated tumor eradication and support adoptive T cell therapy.
A position for a PhD student is available in the laboratory of Experimental Tumor Immunology,
Department of Medical Oncology. This post is for four years to study and exploit genetic and
non-genetic strategies to provide T cells with an improved ability to counteract the
immunosuppressive milieu of tumors. Realistic mouse models that are currently running in the
laboratory will allow testing of such strategies.
Requireme Background:
nts
of  you are experienced in molecular-biological and immunological laboratory
techniques; and
candidate:

you are highly motivated to perform research and to cooperate in a team of
researchers.
Master degree: Yes
IELTS grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Janssen and Pan-R
School/Depa
rtment:
Project Title:
Erasmus University Medical Center Rotterdam
Department of Gastroenterology and Hepatology
(Research school: Erasmus Postgraduate School Molecular Medicine)
The Netherlands
Regulation of the kinome by hepatitis virus infection and antiviral interferon therapy: RNAi
Abstract:
Requireme
nts
of
candidate:
Supervisor
informatio
n:
screening and PepChip profiling approaches
Hepatitis B and C virus (HBV, HCV) infections currently affect over 500 million people
worldwide with high risk of developing hepatocellular carcinoma. Interferon-based standard
medication represents milestone of the antiviral therapy. However, only part of the patients
responds to the treatment with issues of potential severe side-effects. The future improvement
in clinic would depend much on the understanding of virus-host interaction and the working
mechanism of interferon.
A protein kinase is an enzyme that modifies proteins by chemically adding phosphate
groups (phosphorylation). It can regulate almost every property of a protein and is involved
in almost all fundamental cellular processes, including viral infection. Up to date, over 500
different kinases have been identified in human. We hypothesize that HBV/HCV can
modulate particular kinase activity to result in persistent infection, attenuate antiviral
interferon response and trigger oncogenic events.
To systematic study the kinome, we will use RNAi library-based loss-of-function
approach and PepChip-based genome-wide kinase array profiling (invented by Prof. M.
Peppelenbosch, the head of the lab), in HBV and HCV cell culture models. Important
findings will be further validated in mice models and patient materials.
Therefore, the following research questions are proposed:
1. Identify three categories of kinases:
- Regulated by HBV/HCV infection
- Regulated by interferon treatment
- Regulated by the interaction between infection and antiviral treatment
2. Bioinformatic analysis of identified kinases into key pathways
3. Validate the functions of discovered important kinases in mice models and patient
materials.
Background: Molecular Biology/Cell biology/Virology
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor: Prof.dr. H.L.A. Janssen
Dept. Of Gastroenterology and Hepatology
Erasmus MC University Medical Center Rotterdam
T: +31 10 7035942
E: h.janssen@erasmusmc.nl
http://www.gastrolab.nl/
Selected recent publications:
 Janssen HLA, Zonneveld van M, Senturk H, Zeuzem S, Akarca U, Cakaloglu Y, Simon
K, So Man Kit T, Gerken G, Man de RA, Niesters HG, Zondervan P, Schalm SW (2005)
Pegylated interferon a-2b alone or in combination with lamivudine for HBeAg-positive
chronic hepatitis B: a randomised trial. Lancet 365, 123-129.
 Veldt BJ, Heathcote EJ, Wedemeyer H, Reichen J, Hofmann WP, Zeuzem S, Manns M,
Hansen BE, Schalm SW, Janssen HLA. Sustained virological response leads to an
improved clinical outcome in patients with hepatitis C and advanced fibrosis. Annals of
Internal Medicine 2007. 147,677-684.
 Buster EH, Flink HJ, Cadaloglu Y, Simon K, Trojan J, Tabak F, So TM, Feinman SV,
Mach T, Akarca US, Schutten M, Tielemans W, van Vuuren AJ, Hansen BE, Janssen HL.
Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients
treated with peginterferon alpha-2b. Gastroenterology. 2008. 135(2):459-67.
 Darwish Murad S, Plessier A, Hernandez-Guerra M, Fabris F, Eapen CE, Bahr MJ,
Trebicka J, Morard I, Lasser L, Heller J, Hadengue A, Langlet P, Miranda H, Primignani
M, Elias E, Leebeek FW, Rosendaal FR, Garcia-Pagan JC, Valla DC, Janssen HLA, for
the European Network for Vascular Disorders of the Liver (EN-Vie). Risk Factors,
Management and Outcome of Budd-Chiari Syndrome. Annals of Internal Medicine,
2009;151:167-75.
 Reijnders JGP, Perquin MJ, Zhang N, Hansen BE, Janssen HLA. Nucleos(t)ide analogues
induce temporary hepatitis B e antigen seroconversion in most patients with chronic
hepatitis B. Gastroenterology 2010;139:491-8.
 Zoutendijk R, Reijnders JG, Brown A, Zoulim F, Mutimer D, Deterding K, Petersen J,
Peter Hofmann W, Buti M, Santantonio T, van Bömmel F, Pradat P, Oo Y, Luetgehetmann
M, Berg T, Hansen BE, Wedemeyer H, Janssen HL; for the VIRGIL Surveillance Study
Group. Entecavir treatment for chronic hepatitis B: Adaptation is not needed for the
majority of naïve patients with a partial virological response. Hepatology. 2011.
54(2):443-451.
 Schouten JN, Garcia-Pagan JC, Valla DC, Janssen HL. Idiopathic noncirrhotic portal
hypertension. Hepatology. 2011 May 13. doi: 10.1002/hep.24422. [Epub ahead of print]
Supervisor: Prof.dr. M.P. Peppelenbosch
Dept. Of Gastroenterology and Hepatology
Erasmus MC University Medical Center Rotterdam
T: +31 10 7032792
E: m.peppelenbosch@erasmusmc.nl
http://www.gastrolab.nl/
Selected recent publications:
 Peppelenbosch MP, Qiu RG, de Vries-Smits AMM, Tertoolen LGJ, de Laat SW,
McCormick F, Hall A, Symons MH, Bos JL Rac mediates growth factor- induced
arachidonic acid release. Cell. 1996. 81: 849-856.
 Peppelenbosch MP, Spek CA. Type I diabetes: A role for tissue factor in islet
transplantation? Lancet 2002. 360:1999-2000
 van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ,
Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP. Indian
Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Nature Genet. 2004. 36:277-82.
 Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F, Peppelenbosch MP.
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol.
2006. 4:e232.
 Diks SH, Sartori da Silva MA, Hillebrands JL, Bink RJ, Versteeg HH, van Rooijen C,
Brouwers A, Chitnis AB, Peppelenbosch MP, Zivkovic D. d-Asb11 is an essential
mediator of canonical Delta-Notch signalling. Nature Cell Biol. 2008. 10:1190-8.
 Parikh K, Poppema S, Peppelenbosch MP, Visser L. Extracellular ligation-dependent
CD45RB enzymatic activity negatively regulates lipid raft signal transduction. Blood.
2009. 113(3):594-603
 Sikkema AH, Diks SH, den Dunnen WF, ter Elst A, Scherpen FJ, Hoving EW, Ruijtenbeek
R, Boender PJ, de Wijn R, Kamps WA, Peppelenbosch MP, de Bont ES. Cancer Res.
2009. 69(14):5987-95.
 Parikh K, Peppelenbosch MP. Kinome profiling of clinical cancer specimens. Cancer
Res. 2010 70(7):2575-8.
 Chaves Neto AH, Queiroz KC, Milani R, Paredes-Gamero EJ, Justo GZ, Peppelenbosch
MP, Ferreira CV. Profiling the changes in signaling pathways in ascorbic
acid/β-glycerophosphate-induced osteoblastic differentiation. J Cell Biochem. 2011
112(1):71-7.
 van Veelen W, Korsse SE, van de Laar L, Peppelenbosch MP. The long and winding road
to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.
Oncogene. 2011 30(20):2289-303.
 Hazen AL, Diks SH, Wahle JA, Fuhler GM, Peppelenbosch MP, Kerr WG. Major
remodelling of the murine stem cell kinome following differentiation in the hematopoietic
compartment. J Proteome Res. 2011 10(8):3542-50.
Co-supervisor:
Drs. Q. Pan
Dept. Of Gastroenterology and Hepatology
Erasmus MC University Medical Center Rotterdam
T: +31 10 7034545
E: q.pan@erasmusmc.nl
http://www.gastrolab.nl/
Selected recent publications:
 Pan QW, Zhong SY, Liu BS, Liu J, Cai R, Wang YG, Liu XY, Qian C. Enhanced
sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed
oncolytic adenovirus. Acta Pharmacol Sin. 2007 28(12):1996-2004.
 Pan Q, Liu B, Liu J, Cai R, Liu X, Qian C. Synergistic antitumor activity of XIAP-shRNA
and TRAIL expressed by oncolytic adenoviruses in experimental HCC. Acta Oncol. 2008
47(1):135-44.
 Pan Q, Henry SD, Metselaar HJ, Scholte B, Kwekkeboom J, Tilanus HW, Janssen HL,
van der Laan LJ. Combined antiviral activity of interferon-alpha and RNA interference
directed against hepatitis C without affecting vector delivery and gene silencing. J Mol
Med (Berl). 2009 87(7):713-22.
 Pan Q, Tilanus HW, Janssen HL, van der Laan LJ. Prospects of RNAi and
microRNA-based therapies for hepatitis C. Expert Opin Biol Ther. 2009 9(6):713-24.
 Pan Q, Metselaar HJ, de Ruiter P, Kwekkeboom J, Tilanus HW, Janssen HL, van der Laan
LJ. Calcineurin inhibitor tacrolimus does not interfere with the suppression of hepatitis C
virus infection by interferon-alpha. Liver Transpl. 2010 16(4):520-6.
 van der Laan LJ, Wang Y, Tilanus HW, Janssen HL, Pan Q. AAV-mediated gene therapy
for liver diseases: the prime candidate for clinical application? Expert Opin Biol Ther.
2011 11(3):315-27.
 Pan Q, Fouraschen SM, Kaya FS, Verstegen MM, Pescatori M, Stubbs AP, van Ijcken W,
van der Sloot A, Smits R, Kwekkeboom J, Metselaar HJ, Kazemier G, de Jonge J, Tilanus
HW, Wagemaker G, Janssen HL, van der Laan LJ. Mobilization of hepatic mesenchymal
stem cells from human liver grafts. Liver Transpl. 2011 17(5):596-609.
 Pan Q, Tilanus HW, Janssen HL, van der Laan LJ. Ribavirin enhances
interferon-stimulated gene transcription by activation of the interferon-stimulated response
element. Hepatology. 2011 53(4):1400-1.
 Pan Q, de Ruiter PE, von Eije KJ, Smits R, Kwekkeboom J, Tilanus HW, Berkhout B,
Janssen HL, van der Laan LJ. FEBS Lett. 2011 585(7):1025-30.
Prof. Dr. M. Van Driel
School/Dep Erasmus University Medical Center Rotterdam Faculty of Medicine
Department of Internal Medicine
artment:
Laboratory for Calcium and Bone metabolism The Netherlands
Project Title:
Unraveling the molecular mechanisms of metastases to the bone.
Abstract:
Primary cancers spread to distant organs with characteristic preference. The skeleton is one of the
most common organs to be affected by metastatic cancer. Both breast and prostate cancer account
for more than 80% of cases of metastatic bone disease and are yet incurable. We have set up a
complete human co-culture model with osteoblasts (bone forming cells) and prostate metastases
to study cellular cross-talk and migration of tumor cells.
Preliminary results showed that the early osteoblast differentiation stage is very important for
interaction with metastatic cells. Comparative gene expression profiling identified 66 and 453
genes at least 1.5-fold higher and lower expressed respectively, in the early compared to the late
differentiation stage. This reveals candidate genes that can interfere in osteoblast - tumor cell
interaction.
The aim of the PhD project is to further identify and characterize osteoblast genes that are
functionally involved in the interaction with metastatic cells and may form the basis of new
therapeutics.
Therefore we will perform gene arrays on osteoblasts and metastatic tumor cells after cell-cell
contact, silence candidate genes or proteins and perform functional assays.
Requireme Background: cell biology, molecular biology
nts
of Master degree: with good results
candidate: IELTS Grade: 7 or higher (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Other: enthusiastic, communicative, social, punctual, creative
Supervisor Supervisor: Prof. Dr. M. Van Driel m.vandriel@erasmusmc.nl
informatio Co-Supervisor: Prof. J. Van Leeuwen j.vanleeuwen@erasmusmc.nl
Personal website: http://www.erasmusmc.nl/47411/206403/research/Calcium-Bot?version=1
n:
List of publications:
J Bone Miner Res. 2011; 9:2045-51 J Proteome Res. 2010; 9:4688-700
Stem Cells. 2010; 5:916-27 FASEB J. 2007; 11:2949-60
FASEB J. 2006; 13:2417-9
Prof. Gerard Borst
School/De
partment:
Erasmus University Medical Center Rotterdam Department of Neuroscience
The Netherlands
Project Title:
Developmental plasticity in the auditory system
Abstract:
Before hearing onset, cells in the auditory system are already electrically active. We recently
found that the origin of this patterned activity lies in the cochlea, where hair cells fire calcium
action potentials which trigger brief bursts of action potentials in auditory neurons each time they
fire a Ca2+ spike (Tritsch et al, Nature Neuroscience 2010, 13, 1050–1052). This theta-like activity
may limit the impact of synaptic depression and promote consolidation of synapses, but this has
not yet been tested. The aim of this project is to characterize the impact of this patterned activity
on the development of the central auditory system. Its impact will be studied on the calyx of Held
synapse, a giant synapse in the auditory brainstem which is uniquely accessible for both
electrophysiology and imaging. We have previously shown that it is possible to visualize its
formation using in vivo two-photon imaging (Rodriguez-Contreras et al, PNAS 2008, 105,
5603-5608) and that it is possible to study its short-term plasticity with in vivo
electrophysiological recordings (Crins et al, J Neurosci 2011, 31, 11706). In this project, a
combination of molecular biological, imaging and electrophysiological techniques will be used to
study how electrical activity promotes formation and development of this synapse.
Requirem Background: Strong, proven interest in Neuroscience, Master in Biology, Medicine or Physics
ents
of Master degree: Yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisor: Prof. Dr. J. Gerard G. Borst E-mail: g.borst@erasmusmc.nl
informatio Websites:
http://www.neuro.nl (Department of Neuroscience)
n:
http://beta.neuro.nl/research/borst (research page and recent publications)
http://www.onwar.nl (Graduate school)
Prof. Gerard van Rhoon
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Radiation Oncology – Section Hyperthermia
(part of Erasmus MC research school Molmed) The Netherlands
Project
Title:
Abstract:
Assessment of dielectric and thermal properties of human tissues and their impact in medical
applications
In modern medicine, patients are more and more exposed to electromagnetic fields (EMF).
Accurate knowledge of the dielectric and thermal properties of tissues is required to calculate the
energy deposition and thermal exposure of EMF during medical applications, such as Magnetic
Resonance Imaging (MRI) and cancer treatments using hyperthermia (heating of the tumor to
stimulate radiotherapy or drugs). Variations in tissue properties have a major impact on the EMF
and temperature patterns and, consequently, on the safety and quality of these medical
applications. Current tissue data is obtained by animals or samples from a limited number of
human post-mortem scans. We expect that the properties of living human tissues differ greatly
from those obtained in the existing literature. In addition, there are inter-patient variations
dependent on e.g. age, sex, tumor-type etc.
The goal of this project is to assess the variations in dielectric and thermal tissue properties, such
that it can be used to assess their impact in medical applications. Hereto, various tissue types will
be measured, both in-vivo and ex-vivo, by using different measurement methods, such as coaxial
probe and electric properties Tomography using MRI (EPT-MRI). In addition, numerical
modeling will be used to study the impact of the obtained variations on the exposure during MRI
examinations and hyperthermia treatments.
Requireme Background: Affinity with basic electromagnetism, medical applications and experimental work.
nts
of Master degree: Yes, Electrical / Biomedical Engineering, Physics or equivalent
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score) Other: good communicator
Supervisor Prof. Dr. G.C. Van Rhoon E-mail: g.c.vanrhoon@erasmusmc.nl
informatio The hyperthermia unit consists of about 10 highly motivated researchers from different countries
n:
(Italy, Tsjech, Iran and The Netherlands) working on the development of hyperthermia. The
research is highly translation and multidisciplinary of nature.
List of recent publications
1. Bakker JF, Paulides MM, Neufeld E, Christ A, Kuster N, van Rhoon GC. Children and
adults exposed to electromagnetic fields at the ICNIRP reference levels: theoretical
assessment of the induced peak temperature increase. Phys Med Biol. 2011 Aug
7;56(15):4967-89. Epub 2011 Jul 19.
2. Fatehi D, van der Zee J, van Rhoon GC. Intra-patient comparison between two annular
phased array applicators, Sigma-60 and Sigma-Eye: Applied RF powers and
intraluminally measured temperatures. Int. J. Hyperthermia, May 2011; 27(3): 214–223
3. van Rhoon GC, Aleman A, Kelfkens G, Kromhout H, van Leeuwen FE, Savelkoul HFJ,
Wadman WJ, van de Weerdt RDHJ, Zwamborn APM, van Rongen E, The
Electromagnetic Fields Committee of the Health Council of the Netherlands Health
Council of the Netherlands: No need to change from SAR to time-temperature relation
in electromagnetic fields exposure limits. Int. J. Hyperthermia, June 2011; 27(4):
399–404
4. de Bruijne M, van der Zee J, Ameziane A, van Rhoon GC. Quality control of
superficial hyperthermia by treatment evaluation. Int. J. Hyperthermia, May 2011; 27(3):
199–213
5. Canters RA, Franckena M, van der Zee J, van Rhoon GC. Optimizing deep
hyperthermia treatments: are locations of patient pain complaints correlated with
modelled SAR peak locations? Phys Med Biol. 2011 Jan 21;56(2):439-51. Epub 2010
Dec 22.
6. Van Der Zee J, De Bruijne M, Mens JW, Ameziane A, Broekmeyer-Reurink MP, Drizdal
T, Linthorst M, Van Rhoon GC. Reirradiation combined with hyperthermia in breast
cancer recurrences: overview of experience in Erasmus MC. Int J Hyperthermia.
2010;26(7):638-48.
7. de Bruijne M, van der Holt B, van Rhoon GC, van der Zee J. Evaluation of CEM43
degrees CT90 thermal dose in superficial hyperthermia: a retrospective analysis.
Strahlenther Onkol. 2010 Aug;186(8):436-43.
8. Bakker JF, Paulides MM, Christ A, Kuster N, van Rhoon GC. Assessment of induced
SAR in children exposed to electromagnetic plane waves between 10 MHz and 5.6 GHz.
Phys Med Biol. 2010 Jun 7;55(11):3115-30.
9. Paulides MM, Bakker JF, Linthorst M, van der Zee J, Rijnen Z, Neufeld E, Pattynama
PM, Jansen PP, Levendag PC, van Rhoon GC. The clinical feasibility of deep
hyperthermia treatment in the head and neck: new challenges for positioning and
temperature measurement. Phys Med Biol. 2010 May 7;55(9):2465-80.
10. Li L, ten Hagen TL, Schipper D, Wijnberg TM, van Rhoon GC, Eggermont AM,
Lindner LH, Koning GA. Triggered content release from optimized stealth
thermosensitive liposomes using mild hyperthermia. J Control Release. 2010 Apr
19;143(2):274-9.
11. Bakker JF, Paulides MM, Westra AH, Schippers H, Van Rhoon GC. Design and test of a
434 MHz multi-channel amplifier system for targeted hyperthermia applicators. Int J
Hyperthermia. 2010;26(2):158-70.
12. Franckena M, Canters R, Termorshuizen F, Van Der Zee J, Van Rhoon G. Clinical
implementation of hyperthermia treatment planning guided steering: A cross over trial to
13.
14.
15.
16.
17.
18.
19.
20.
assess its current contribution to treatment quality. Int J Hyperthermia.
2010;26(2):145-57.
Canters RA, Wust P, Bakker JF, van Rhoon GC. A literature survey on indicators for
characterisation and optimisation of SAR distributions in deep hyperthermia, a plea for
standardisation. Int J Hyperthermia. 2009 Nov;25(7):593-608
Franckena M, Fatehi D, de Bruijne M, Canters RAM, van Norden Y, Mens JW, van
Rhoon GC and van der Zee J. Hyperthermia dose-effect relationship in 420 patients with
cervical cancer treated with combined radiotherapy and hyperthermia. Eur J Cancer.
2009 Jul;45(11):1969-78. Epub 2009 Apr 8.
Canters RA, Franckena M, Paulides MM, van Rhoon GC. Patient positioning in deep
hyperthermia: influences of inaccuracies, signal correction possibilities and optimization
potential. Phys Med Biol. 2009 Jun 21;54(12):3923-36. Epub 2009 Jun 2.
Bakker JF, Paulides MM, Obdeijn IM, van Rhoon GC and van Dongen KWA. An
ultrasound cylindrical phased array for deep heating in the breast: theoretical design
using heterogeneous models. Phys. Med. Biol. 54 (2009) 3201–3215
Fatehi D, van der Zee J, van Rhoon GC. Hyperthermia: A New Cancer Treatment
Modality. Journal of Isfahan Medical School Vol 27, No 94, June 2009
Franckena M, Lutgens LC, Koper PC, Kleynen CE, van der Steen-Banasik EM, Jobsen
JJ, Leer JW, Creutzberg CL, Dielwart MF, van Norden Y, Canters RA, van Rhoon GC,
van der Zee J. Radiotherapy and hyperthermia for treatment of primary locally
advanced cervix cancer: results in 378 patients. Int J Radiat Oncol Biol Phys. 2009 Jan
1;73(1):242-50. Epub 2008 Nov 5.
Wal E van der, Franckena M, Wielheesen DH, van der Zee J, van Rhoon GC. Steering in
locoregional deep hyperthermia: evaluation of common practice with 3D-planning. Int J
Hyperthermia. 2008 Dec;24(8):682-93.
Canters RA, Franckena M, van der Zee J, van Rhoon GC. Complaint-adaptive power
density optimization as a tool for HTP-guided steering in deep hyperthermia treatment
of pelvic tumors. Phys Med Biol. 2008 Dec 7;53(23):6799-820.
Prof. Hans van der Steen
School/De
partment:
Erasmus University Medical Centre Rotterdam Department of Neuroscience
The Netherlands
Project Title:
Eye-hand coordination: hands on neurodegenerative diseases
Abstract:
Recently we developed a device that provides an objective measure of degradation of motor
performance in elderly people. Quantification of motor performance decline builds on current
knowledge on the causes of neuro-degenerative diseases and current insight in the neural substrate
of the sensorimotor pathways.
Objective and quantifiable behavioural marker data, e.g. relative latencies between eye and head,
and execution speed of eye and hands provide a direct insight in the behavioral motor
performance of a given subject. Pilot data show that motor coordination allows not only to
discriminate between different forms of neurodegenerative diseases at an early stage, but also to
monitor progression of the disease.
Collaboration is planned between Dutch en Chinese research teams to make a comparison of
mutually collected behavioural marker data to clinical observations and biomarker data, to
optimize and validate this technique in a Dutch and Chinese clinical setting. In addition, we will
utilize the multi-disciplinary expertise from neurologists, geriatrists, neurophysiologists and
engineers to develop a decision model to predict the course and time path of motor performance
decline in elderly people suffering from neuro- degenerative diseases.
Requirem Background:
ents
of The candidate should have:
candidate: A strong theoretical and practical background in Neurology
AND interest in health technology engineering.
Expertise in programming in Matlab,
Preferably also mathematical and modeling expertise
Social skills to work with patients.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisor: Prof. dr. / Dr. J van der Steen
informatio Email: j.vandersteen@erasmusmc.nl Personal website : www.neuro.nl
Current Research
n:
The focus is on sensorimotor integration with special interest on plasticity in vestibular ocular
reflexes, visual development, binocular vision and cognitive aspects of visually and memory
guided motor behaviour (e.g. eye-hand coordination) in healthy humans and in patient
populations.
Visual development: We developed a new method to quantify normal and abnormal visual
development in children from the age of 4 months. With this method, children with cerebral visual
impairments (CVI), cerebral palsy (CP) and intellectual disabilities are tested for visual
information processing disorders related
to abnormal brain development. In collaboration with the dept. of neonatology, we will also start a
study to relate functional development on visual function to DTI brain imaging in a cohort of
prematurely born children.
Visual function: Recently we developed and did a feasibility study for a method to quantify field
defects in glaucoma patients based on eye movement responses. Following up on this line of
research, we have started a collaboration with the Rotterdam Eye Hospital and the Vision
Research Centre, Chennai, India in project aimed to the early detection of glaucoma.
Vestibular function: The research on vestibular problems focuses on the central organization of
spatial memory and the role of visual and vestibular information on updating. In addition,
we advise on a population study performed by ENT on vestibular problems in the elderly,
measure “special cases” of patients with vestibular problems
Eye-hand coordination. We use eye-hand coordination parameters to quantify motor coordination
impairments in patients with Alzheimer, Lewy Body dementia, progressive supranuclear palsy
(PSP) and Parkinson. In this study we collaborate with depts. Neurology and Geriatry. In
collaboration with Jiao Tong University, Shanghai and Aerospace department, TU Delft we
applied for NWO-JSTP grant to investigate to what extentbiomarker (Tau, alpha-synuclein) levels
correlate to motor coordination impairments.
List of recent publications
Goossens HH, Hoebeek FE, Van Alphen AM, Van Der Steen J, Stahl JS, De Zeeuw CI,
Frens MA. (2004). Simple spike and complex spike activity of floccular Purkinje cells
during the optokinetic reflex in mice lacking cerebellar long-term depression. Eur. J.
Neurosci. 19(3):687-97.
Van der Steen J., Goumans J., deJongste A.H.C. and Houben M.M.J. (2005). Angular
and Linear vestibulo-ocular responses in humans. Ann. NY Acad. Sci. 1039:68-80.
Goumans J., Boumans L.J.J.L.M., Van der Steen J., Feenstra L. (2004). Het superior
canaldehiscence syndroom. Ned. Tijdschrift voor Geneeskunde. 149(24):1320-1325.
Houben M.M.J., Goumans J. and Van der Steen J. (2006) Recording three dimensional
eye movements: scleral search coils versus video-oculography. Invest Ophth Vis Sci.
2006;47:179-187
Van der Steen J (2009) The vestibulo-ocular reflex . In Springer Encyclopedia Neuroscience.
Pel J J M; Bagheri J; van Dam L M; van den Berg-Emons H J G; Horemans H L D;
Stam H J; van der Steen J (2009) Platform accelerations of three different whole-body
vibration
devices and the transmission of vertical vibrations to the lower limbs
Goumans J; Houben M M J; Dits J; van der Steen J. (2010) Peaks and troughs of
threedimensional vestibulo-ocular reflex in humans. Journal of the Association for Research
in Otolaryngology : JARO;11(3):383-93.
Pel J J M; Manders J C W; van der Steen J (2010) Assessment of visual orienting
behaviour in young children using remote eye tracking: methodology and reliability. Journal
of neuroscience methods; 189(2): 252-6.
Boot FH, Pel JJ, van der Steen J, Evenhuis HM. Cerebral Visual Impairment: which
perceptive visual dysfunctions can be expected in children with brain damage? A systematic
review. Res Dev Disabil. 2010 Nov-Dec;31(6):1149-59. Epub 2010 Sep 6.
Pel JJ, van der Does JM, Boot FH, de Faber JT, van der Steen-Kant SP, Willemsen SP,
van der Steen J. Effects of visual processing and congenital nystagmus on visually guided
ocular motor behaviour. Dev Med Child Neurol. 53(4):344-9. Epub 2010 Dec 17.
Boot FH, Pel JJ, Evenhuis HM, van der Steen J. Quantification of visual orienting
responses to form and motion stimuli in healthy children aged 0-12 years using remote eye
tracking. (under revision).
Prof. Hokken & Dr. De Graaff
School/Fa
culty:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
The Netherlands
Department of Pediatrics
Genetics of Growth Disorders: Genetic studies in patients with Isolated Growth Hormone
Deficiency, Combined Pituitary Hormone Deficiency and Idiopathic Short Stature
The project, for which we would like to invite the Chinese PhD student, aims to
characterise gene defects associated with Isolated Growth Hormone Deficiency (IGHD),
Combined Pituitary Hormone Deficiency (CPHD) and / or Idiopathic Short Stature
(ISS). Our former studies showed that only a small minority of the Dutch IGHD, CPHD
and ISS cases could be explained by mutations in GH1, GHRHR and HMGA2 in IGHD
patients (DE GRAAFF et al. 2009; GORBENKO DEL BLANCO et al. 2011); PROP1,
HESX1, POU1F1, LHX3, LHX4, HHIP, SHH and OTX2 in CPHD patients (DE
GRAAFF et al. 2010; GORBENKO DEL BLANCO et al. 2011 in preparation) and
GHR, IGF1 and IGF1R in ISS / GHI patients (GORBENKO DEL BLANCO et al. 2011
and unpublished data). Since the majority of these patients still have the unsatisfying
diagnose of ‘idiopathic’ growth disorders, further investigations are considered
necessary to explain their condition.
In Rotterdam, we have collected DNA and clinical data of 244 patients with GHD (129 IGHD
patients and 115 CPHD patient) and of 105 children with ISS. Furthermore, the collaboration
with the Department of Clinical Genetics and the implementation of the new Growth Center
Rotterdam, initialized in 2011, will provide DNA of new patients with growth disorders.
In our cohort of patients, we aim to perform genetic screening of new candidate genes and the
regulating regions of genes already known to be involved in IGHD, CPHD and ISS.
For details, see the research protocol attached
Requireme Background: (medical) biology or medicine
nts
of Master degree: yes
candidate: IELTS: At least 7.0 (min. 6.0 per sub-score) or TOEFL: 100 (min. 20 per sub-score)
Other: social, hard-working, enthusiastic, independent
Supervisor Prof. dr. A.C.S Hokken-Koelega and Dr. Laura de Graaff
informatio E-mail: a.hokken@erasmusmc.nl
n:
Prof. Jan Willem Coebergh
School/De
partment:
Project
Titles:
Abstract:
Erasmus University Medical Center Rotterdam
Department of Public Health, which collaborates intensively with the Eindhoven Cancer Registry
of the Comprehensive Cancer Centre South The Netherlands
1. Comparison prevalence of cancer among European countries taking multiple primary
cancers into consideration
2. Co-morbidities among (elderly) cancer patients and their impact on burden of cancer and
prognosis
3. Estimation of progress against cancer
Short description of your achievements or relevant information
1. Cancer prevalence is a main measure for the disease burden among various populations,
in fact being an indicator of awareness. It has risen in most industrialized countries from
about 1% 30-40 years ago to about 4% nowadays and up to 20% at old age. It is the
product of incidence and survival and increases rapidly in case of mass screening of
breast and prostate cancer. In the past years, our department engaged in studies of
incidence, survival and mortality from cancer within the EU and is thus able to make
estimations of prevalence based on available data. Within the total prevalence one can
also discern the so called care-prevalence, i.e. an indicator of care need. Based on our
large experience in performing studies of multiple cancers we intend to estimate the
prevalence of this, indeed also rapidly rising, group of patients within the total[1]
2. World-wide, population is aging and that is the reason that the Eindhoven Cancer
Registry has routinely recorded data on co-morbidity since 1993. On the one hand
co-morbidity is an indicator of all sorts of complexity, hampering patient safety, and on
the other hand it is a prognostic determinant, especially when the tumour has a
favourable course. The prevalence of co-morbidity clearly rises with age, until about age
80-85 years after which there is also survival of the fittest[2-3]. After more than 50
papers on the topic we also want to make estimations of the prevalence of chronic disease
with the various cancers for the near future based on current trends. These are the input
for estimations of tumour-specific burden of cancer. Through another group of
researchers, at the University of Tilburg, we are also able to study the impact on quality
of life of having one or more concomitant diseases.
3. Progress against cancer can be measured in various ways, especially by considering
trends in incidence, mortality and survival[4-5]. We want to make such analyses for a
variety of cancers within the various EU-countries and elsewhere, depending on the
availability of data. Within about a year from now there will be a new edition of Cancer
Incidence in 5 Continents, i.e. volume 11 which will facilitate such estimations.
Requirem Background: 2-3 medical students/doctors/medical researchers with epidemiological/statistical
ents
of training. Preferably with experience in scientific writing but not a must.
candidate: Master degree: Yes
IELTS Grade: 7.0 (minimal 6.0 per sub-score) or
TOEFL: 100 (minimal 20 per sub-score) GMAT/GRE: (if applicable)
Supervisor Prof. Jan Willem Coebergh
informatio Email address: j.coebergh@erasmusmc.nl
Personal website / Recent publication list, preferably last 3-5 years (1-2 pages)
n:
Prof. Johan Kros 1
School/Fa
culty:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
Department of Pathology; subdivision Neuropathology The Netherlands
Bone marrow-derived stem / progenitor cells in tumor neovascularization and/or regenerative
organs by using zebrafish as a model organism: from basic views to clinical perspectives.
In recent studies it was suggested that bone marrow-derived stem cells or progenitor cells
contribute to neovascularisation of ischemic tissues and of tumors. There are at least three
different populations of stem cells in the bone marrow: hematopoietic stem cells (HSCs),
endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs). These subtypes have
heterogeneous immunophenotypes which partly overlap. Following particular triggers the cells
enter the circulation and their immunophenotypes are modulated once they reach a tumor
microenvironment. The concept of using these bone marrow-derived stem cells for cardiovascular
repair or as therapeutic targets to cancers holds great clinical potential.
So far, little is known about the contribution of these subsets in vivo. In order to study the relative
contribution of EPCs, HSCs and MSCs in neovascularisation during tissue repair and tumor
progression, the development of an animal model in which particular subsets are eliminated is
required. The selective elimination of a particular subset can be reached by using pharmacological
agents or alternatively, by genetic knockdown. Zebrafish has proven to be a valuable model
organism for studying human diseases. The zebrafish kidney marrow is considered to be the
analogous of the mammalian bone marrow.1 Many orthologues of mammalian genes required for
blood and vasculature development are expressed in the zebrafish kidney marrow cDNA library.1
So far, we have successfully used zebrafish as a model organism for studying the effects of
caldesmon and Glut1 on the development and pathology of the cardiovascular system including
the ocular vasculature and the blood-brain barrier2-9 by creating genetic knock-downs.
In this proposal we will attempt to expand our investigations beyond single gene knockdown by
developing approaches for selective ablation of defined cell populations as EPCs, HSCs and
MSCs in the zebrafish during the process of neovascularization.
References:
1.
Song HD, Sun XJ, Deng M, et al. Hematopoietic gene expression profile in zebrafish kidney
marrow. Proc Natl Acad Sci U S A 2004;101:16240-5.
2.
Zheng PP, Severijnen LA, van der Weiden M, Willemsen R, Kros JM. A crucial role of
caldesmon in vascular development in vivo. Cardiovasc Res 2009;81:362-9.
3.
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Images in cardiovascular medicine.
Functional cardiac phenotypes in zebrafish caldesmon morphants: a digital motion analysis.
Circulation 2009;120:e145-6.
4.
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Reduction of caldesmon expression
induces apoptosis and causes disassembly of the sarcomeric protein complex in
cardiomyocytes in vivo. Cell Cycle 2009;8:325-6.
5.
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Caldesmon is essential for cardiac
morphogenesis and function: in vivo study using a zebrafish model. Biochem Biophys Res
Commun 2009;378:37-40.
6.
Zheng PP, Romme E, van der Spek PJ, Dirven CM, Willemsen R, Kros JM. Glut1/SLC2A1 is
crucial for the development of the blood-brain barrier in vivo. Ann Neurol 2010;68:835-44.
7.
Zheng PP, Romme E, van der Spek PJ, Dirven CM, Willemsen R, Kros JM. Defect of
development of ocular vasculature in Glut1/SLC2A1 knockdown in vivo. Cell Cycle
2011;10:1871 - 2.
8.
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Images. Different patterns of circulatory
shunting in zebrafish caldesmon morphants: a digital motion analysis. Heart Lung Circ
2010;19:251-2.
9.
Zheng PP, van der Spek PJ, Dirven CM, Willemsen R, Kros JM. Sinus venosus defect (SVD)
identified in zebrafish Glut1 morphants by video imaging. Int J Cardiol 2011.
Requireme Background:
nts
of For this project a master in Medicine, Biomedical science, Biochemistry or Medical Biology is
candidate: preferable.
Experience with standard techniques used in molecular biology is a preference.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or TOEFL: 100 (min. 20 per sub-score)
Supervisor
informatio
n:
Prof. dr. Johan M. Kros, MD, PhD. E-mail: j.m.kros@erasmusmc.nl
http://www.erasmusmc.nl/pathologie/research/kros/162476/
Chief, Neuropathology Division of the Dept. of Pathology
Chair, EORTC Neuropathology Panel
Chair, Dutch Neuropathological Society
Editorial Board WHO Classification of Tumours of the CNS
The research team of Prof. Kros consists of Dr. P. Zheng (Staff), Dr. D. Mustafa (postdoc), Dr. K.
Huizer (PhD student), Mr. van der Weiden (research technician). There is intensive collaboration
with Dr. R. Willemsen (Dept. of Clinical Genetics; head of zebrafish facility); Dr. T.M. Luider
(Dept. of Neurology, head of proteomics facility); Prof. J. Foekens (Dept. of Medical Oncology)
and the collaborators of the Dept. of Neurosurgery and Neuro-Oncology.
Research projects of the last 5 years:
PhD student position financed by the Department of Pathology of the Erasmus MC, resulting in
Thesis entitled “Low-molecular Caldesmon In Glioma Vasculature” by Dr. P. Zheng, defended on
February 16, 2005.
PI in project for PhD student financed by Mrace of the Erasmus MC, starting May 2005,
(collaboration with dr. T.M. Luider of the Dept. of Neuro-Oncology) resulted in thesis entitled
“Identifying proteins involved in glioma angiogenesis: a proteomics approach” by Dr. D. Mustafa,
defended on November 10, 2009.
Co-investigator in project entitled “The genotyping of anaplastic oligodendroglioma in a
prospective randomized clinical trial” by M.J. van den Bent and J.M. Kros, granted by the Dutch
Cancer Society, 2005/2006.
Co-investigator in project “MGMT gen promoter methylation in EORTC study 26951”. M.J. van
den Bent, J.M.Kros, W.N.M. Dinjens. KWF Translational Research Grant EMCR 2007-3932.
Co-investigator in project “Evaluation of l-caldesmon as biomarker for brain tumor monitoring”
by T.M.Luider, P.A.E. Sillevis Smitt, J.M. Kros. Zon MW; 2006-2010.
PI in postdoc project for KWF (Dutch cancer society) granted project:”Towards evidence-based
pathology diagnosis of gliomas. A panel review combining pathological and molecular parameters
on EORTC trials 26951 and 26882”. Jan 1, 2011- 2013.
PI in PhD KWF (Dutch cancer Society) granted project: “Identification and utilization of
pathways involved in brain metastasis of common cancers”. July 1, 2011-2015.
List of recent publications:
-
Hegi ME, Diserens A-C, Gorlia T, Hamou M-F, de Tribolet N, Weller M, Kros JM,
Hainfellner JA, Mason WP, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross G,
Janzer R, Stupp R. MGMT Gene Silencing and Response to Temozolomide in Glioblastoma.
New Engl J Med 352:997-1003, 2005.
-
Kros JM, Gorlia T, Kouwenhoven MC, Kouwenhoven MC, Zheng PP, Collins VP,
Figarella-Branger D, Giangaspero F, Giannini C, Mohktari K, Mork SJ, Paetau A,
Reifenberger G, van den Bent MJ. Panel review of anaplastic oligodendroglioma from
European Organization For Research and Treatment of Cancer Trial 26951: Assessment of
consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. J
Neuropathol Exp Neurol 66:545-51, 2007.
-
Mustafa DA, Burgers PC, Dekker LJ, Charif H, Titulaer MK, Sillevis Smitt PA, Luider TM,
Kros JM. Identification of glioma neovascularization-related proteins by using
MALDI-FTMS and nano-LC fractionation to microdissected tumor vessels. Mol Cell
Proteomics 6:1147-57, 2007.
-
Zheng PP, Hop WC, Luider TM, Sillevis Smitt PA, Kros JM. Increased levels of circulating
endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with
gliomas. Ann Neurol 62:40-8, 2007.
-
Zheng PP, Weiden M, Sillevis Smitt PA, Luider TM, Kros JM. Hela /-CaD Undergoes a DNA
Replication-Associated Switch in Localization from the Cytoplasm to the Nuclei of
Endothelial Cells/Endothelial Progenitor Cells in Human Tumor Vasculature. Cancer Biol
Ther 6:886-90, 2007.
-
Zheng PP, van der Weiden M, Kros JM. Hela l-CaD is implicated in the migration of
endothelial cells/endothelial progenitor cells in human neoplasms. Cell Adhesion & Migration
1(2):1-8, 2007.
-
Kros JM, van der Weiden M, Zheng PP, Hop WC, van den Bent MJ, Kouwenhoven CM.
Intratumoral distribution of 1p loss in oligodendroglial tumors. J Neuropathol Exp Neurol
2007; 66(12):1118-23.
-
van den Bent MJ, Kros JM. Predictive and prognostic markers in Neuro-Oncology. J
Neuropathol Exp Neurol 2007; 66(12):1074-1081.
-
Mustafa D, Kros JM, Luider T. Combining laser capture microdissection and proteomics
techniques. Methods Mol Biol 2008 428:159-78.
-
Mustafa D, van der Weiden M, Luider T, Kros JM. Expression sites of colligin 2 in glioma
blood vessels. Brain Pathol 2008, Dec 5.
-
Zheng P, Severijnen LA, Willemsen R, Kros JM. Caldesmon is essential for cardiac
morphogenesis and function: in vivo study using a zebrafish model. Biochem Biophys Res
Commun 2009 2;378(1):37-40.
-
Zheng P, Severijnen L-A, van der Weiden M, Willemsen R, Kros JM. A crucial role of
caldesmon in vascular development in vivo. Cardiovascular Res 2008 Nov 23.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Reduction of caldesmon expression
induces apoptosis and causes disassembly of the sarcomeric protein complex in
cardiomyocytes in vivo. Cell Cycle. 2009 Jan 15;8(2):325-6.
-
Zheng PP, Severijnen LA, van der Weiden M, Willemsen R, Kros JM. Cell proliferation and
migration are mutually exclusive cellular phenomena in vivo: implications for cancer
therapeutic strategies. Cell Cycle. 2009 Mar 15;8(6):950-1.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Haemoglobin staining for in vivo
portraying of functional vasculature in experimental zebrafish embryos. Biochem Biophys
Res Commun. 2009 Mar 20;380(4):823-4.
-
Zheng PP, Kros JM. Challenge of the gap between the current mania of cancer stem cells and
the therapeutic strategy for patients with cancer. Int J Cancer. 2009 Aug 26.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Circulation status of subintestinal vessels is
a sensitive parameter for monitoring suboptimal systemic circulation in experimental
zebrafish embryos. Cell Cycle. 2009 Nov 15;8(22):3782-3.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Images in cardiovascular medicine.
Functional cardiac phenotypes in zebrafish caldesmon morphants: a digital motion analysis.
Circulation. 2009 Oct 27;120(17):e145-6.
-
van den Bent MJ, Dubbink HJ, Sanson M, van der Lee-Haarloo CR, Hegi M, Jeuken JW,
Ibdaih A, Brandes AA, Taphoorn MJ, Frenay M, Lacombe D, Gorlia T, Dinjens WN, Kros
JM. MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant
PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor
Group Study 26951. J Clin Oncol. 2009 Dec 10;27(35):5881-6.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Different Patterns of Circulatory Shunting
in Zebrafish Caldesmon Morphants: A Digital Motion Analysis. Heart Lung Circ. 2009 Nov
12.
-
Mustafa, D. A., A. M. Sieuwerts, et al. (2010). "Overexpression of Colligin 2 in Glioma
Vasculature is Associated with Overexpression of Heat Shock Factor 2." Gene Regul Syst Bio
4: 103-107.
-
Verdijk, R. M., M. A. den Bakker, et al. (2010). "TP53 mutation analysis of malignant
peripheral nerve sheath tumors." J Neuropathol Exp Neurol 69(1): 16-26.
-
Zheng, P. P., E. Romme, et al. (2010). "Glut1/SLC2A1 is crucial for the development of the
blood-brain barrier in vivo." Ann Neurol 68(6): 835-844.
-
Zheng, P. P., L. A. Severijnen, et al. (2010). "Images. Different patterns of circulatory
shunting in zebrafish caldesmon morphants: a digital motion analysis." Heart Lung Circ
19(4): 251-252.
-
Verdijk, RM, den Bakker, MA, Dubbink, HJ, Hop, WCJ, Dinjens, WNM, Kros, JM. (2010)
“TP53 mutation analysis of malignant peripheral nerve sheath tumors”. J Neuropathol Exp
Neurol 69(1):16-26.
-
Zheng, P, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2010).
GLUT1/SLC2A1 is crucial for development of brain microvasculature with blood-brain
barrier properties in vivo: potential clinical implications. NEURO-ONCOLOGY, 12: 11-11
Suppl. 3 SEP 2010.
-
Zheng, PP, Severijnen, LA, Willemsen, R, Kros, JM. (2010). “Different Patterns of
Circulatory Shunting in Zebrafish Caldesmon Morphants: A Digital Motion Analysis”.
HEART LUNG AND CIRCULATION, 19 (4): 251-252.
-
Zheng, PP, Romme, E, van der Spek, PJ, Dirven, CMF, Willemsen, R (Willemsen, Rob);
Kros, JM. (2011). “Defect of development of ocular vasculature in Glut1/SLC2A1
knockdown in vivo” CELL CYCLE, 10 (11): 1871-1872.
-
Kros, JM. (2011). “Grading of Gliomas: The Road From Eminence to Evidence”. (2011).
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 70 (2):
101-109.
-
Zheng, PP,Romme, E,van der Spek, PJ, Dirven, CMF, Willemsen, R, Kros, JM. (2011).
“Glut1/SLC2A1 Is Crucial for the Development of the Blood-Brain Barrier In Vivo”.
ANNALS OF NEUROLOGY, 68 (6): 835-844.
-
Zheng, PP, van der Spek, PJ, Dirven, CM, Kros, JM. (2011) “Sinus venosus defect (SVD)
identified in zebrafish Glut1 morphants by video imaging”. INT J CARDIOL .
-
Zheng PP, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2011) HeNe
laser (633 nm)-coupled confocal microscope allows simulating magnetic resonance
imaging/computed tomography scan of the brain and eye: a noninvasive optical approach
applicable to small laboratory animals. ZEBRAFISH 8(2):83-5.
Prof. Johan Kros 2
School/De
partment:
Project
Title:
Abstract:
Erasmus University Medical Center Rotterdam
Department of Pathology; subdivision Neuropathology The Netherlands
Comparing the molecular pathways operative in malignant peripheral nerve sheath tumors
(MPNST) in man, cats and dogs.
MPNST are rare tumors, with an incidence of 0,0001% that comprise 5-10% of all soft-tissue
sarcomas. At the moment prognosis is poor and therapy mainly consists of resection with
additional chemotherapy. Individuals with the common autosomal dominant hereditary disorder,
neurofibromatosis 1 (NF1) are predisposed to develop MPNST at an incidence of 2%. These
patients carry a germ line mutation in the NF1 tumor suppressor gene encoding neurofibromin
that functions as a suppressor of RAS-mediated signaling. Sporadic cases and NF1-associated
MPNST can derive from benign neurofibroma, or arise in normal peripheral nerves, or, rarely, in
schwannoma, ganglioneuroma or pheochromocytoma. Recently we have investigated the role of
p53 in human MPNST. In sporadic veterinary cases of MPNST c-erbb-2 mutation has been
described to be of importance. We now have the obtained access material of over 100 feline and
canine MPNST that can be evaluated in addition to the human. In human breast carcinoma
overexpression of c-erbb-2 (Her2 neu) has offered an opportunity for targeted therapy using
Herceptin. We wish to investigate the role of Her 2 neu in MPNST in humans, cats and dogs. The
human MPNST tissue array that has been assembled can act as a starting point for the study, in
combination with the DNA samples that have been isolated from these tumors. The feline and
canine cases may offer an opportunity to study the evolutionary conservation of the molecular
pathways of tumorigenesis. If for example c-erb-2 is indeed overexpressed in MPNST new
therapeutic options may be offered to patients suffering from this tumor.
Reference:
Verdijk et al. “TP53 mutation analysis of malignant peripheral nerve sheath tumors”. J Neuropathol
Exp Neurol 2010:69(1):16-26.
Requireme Background:
nts
of For this project a master in medicine, biomedical science, biochemistry or medical biology is
candidate: preferable.
Experience with standard techniques used in molecular biology is a preference.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Prof. dr. Johan M. Kros, MD, PhD.
informatio j.m.kros@erasmusmc.nl
http://www.erasmusmc.nl/pathologie/research/kros/162476/
n:
Full Professor of Neuropathology
Chief, Neuropathology Division of the Dept. of Pathology
Chair, EORTC Neuropathology Panel
Chair, Dutch Neuropathological Society
Editorial Board WHO Classification of Tumours of the CNS
The research team of Prof. Kros consists of Dr. P. Zheng (Staff), Dr. D. Mustafa (postdoc), Dr. K.
Huizer (PhD student), Mr. van der Weiden (research technician). There is intensive collaboration
with Dr. R. Willemsen (Dept. of Clinical Genetics; head of zebrafish facility); Dr. T.M. Luider
(Dept. of Neurology, head of proteomics facility); Prof. J. Foekens (Dept. of Medical Oncology)
and the collaborators of the Dept. of Neurosurgery and Neuro-Oncology.
Research projects of the last 5 years:
PhD student position financed by the Department of Pathology of the Erasmus MC, resulting in
Thesis entitled “Low-molecular Caldesmon In Glioma Vasculature” by Dr. P. Zheng, defended on
February 16, 2005.
PI in project for PhD student financed by Mrace of the Erasmus MC, starting May 2005,
(collaboration with dr. T.M. Luider of the Dept. of Neuro-Oncology) resulted in thesis entitled
“Identifying proteins involved in glioma angiogenesis: a proteomics approach” by Dr. D. Mustafa,
defended on November 10, 2009.
Co-investigator in project entitled “The genotyping of anaplastic oligodendroglioma in a
prospective randomized clinical trial” by M.J. van den Bent and J.M. Kros, granted by the Dutch
Cancer Society, 2005/2006.
Co-investigator in project “MGMT gen promoter methylation in EORTC study 26951”. M.J. van
den Bent, J.M.Kros, W.N.M. Dinjens. KWF Translational Research Grant EMCR 2007-3932.
Co-investigator in project “Evaluation of l-caldesmon as biomarker for brain tumor monitoring”
by T.M.Luider, P.A.E. Sillevis Smitt, J.M. Kros. Zon MW; 2006-2010.
PI in postdoc project for KWF (Dutch cancer society) granted project:”Towards evidence-based
pathology diagnosis of gliomas. A panel review combining pathological and molecular parameters
on EORTC trials 26951 and 26882”. Jan 1, 2011- 2013.
PI in PhD KWF (Dutch cancer Society) granted project: “Identification and utilization of
pathways involved in brain metastasis of common cancers”. July 1, 2011-2015.
List of recent publications:
-
Hegi ME, Diserens A-C, Gorlia T, Hamou M-F, de Tribolet N, Weller M, Kros JM,
Hainfellner JA, Mason WP, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross G,
Janzer R, Stupp R. MGMT Gene Silencing and Response to Temozolomide in Glioblastoma.
New Engl J Med 352:997-1003, 2005.
-
Kros JM, Gorlia T, Kouwenhoven MC, Kouwenhoven MC, Zheng PP, Collins VP,
Figarella-Branger D, Giangaspero F, Giannini C, Mohktari K, Mork SJ, Paetau A,
Reifenberger G, van den Bent MJ. Panel review of anaplastic oligodendroglioma from
European Organization For Research and Treatment of Cancer Trial 26951: Assessment of
consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. J
Neuropathol Exp Neurol 66:545-51, 2007.
-
Mustafa DA, Burgers PC, Dekker LJ, Charif H, Titulaer MK, Sillevis Smitt PA, Luider TM,
Kros JM. Identification of glioma neovascularization-related proteins by using
MALDI-FTMS and nano-LC fractionation to microdissected tumor vessels. Mol Cell
Proteomics 6:1147-57, 2007.
-
Zheng PP, Hop WC, Luider TM, Sillevis Smitt PA, Kros JM. Increased levels of circulating
endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with
gliomas. Ann Neurol 62:40-8, 2007.
-
Zheng PP, Weiden M, Sillevis Smitt PA, Luider TM, Kros JM. Hela /-CaD Undergoes a DNA
Replication-Associated Switch in Localization from the Cytoplasm to the Nuclei of
Endothelial Cells/Endothelial Progenitor Cells in Human Tumor Vasculature. Cancer Biol
Ther 6:886-90, 2007.
-
Zheng PP, van der Weiden M, Kros JM. Hela l-CaD is implicated in the migration of
endothelial cells/endothelial progenitor cells in human neoplasms. Cell Adhesion & Migration
1(2):1-8, 2007.
-
Kros JM, van der Weiden M, Zheng PP, Hop WC, van den Bent MJ, Kouwenhoven CM.
Intratumoral distribution of 1p loss in oligodendroglial tumors. J Neuropathol Exp Neurol
2007; 66(12):1118-23.
-
van den Bent MJ, Kros JM. Predictive and prognostic markers in Neuro-Oncology. J
Neuropathol Exp Neurol 2007; 66(12):1074-1081.
-
Mustafa D, Kros JM, Luider T. Combining laser capture microdissection and proteomics
techniques. Methods Mol Biol 2008 428:159-78.
-
Mustafa D, van der Weiden M, Luider T, Kros JM. Expression sites of colligin 2 in glioma
blood vessels. Brain Pathol 2008, Dec 5.
-
Zheng P, Severijnen LA, Willemsen R, Kros JM. Caldesmon is essential for cardiac
morphogenesis and function: in vivo study using a zebrafish model. Biochem Biophys Res
Commun 2009 2;378(1):37-40.
-
Zheng P, Severijnen L-A, van der Weiden M, Willemsen R, Kros JM. A crucial role of
caldesmon in vascular development in vivo. Cardiovascular Res 2008 Nov 23.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Reduction of caldesmon expression
induces apoptosis and causes disassembly of the sarcomeric protein complex in
cardiomyocytes in vivo. Cell Cycle. 2009 Jan 15;8(2):325-6.
-
Zheng PP, Severijnen LA, van der Weiden M, Willemsen R, Kros JM. Cell proliferation and
migration are mutually exclusive cellular phenomena in vivo: implications for cancer
therapeutic strategies. Cell Cycle. 2009 Mar 15;8(6):950-1.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Haemoglobin staining for in vivo
portraying of functional vasculature in experimental zebrafish embryos. Biochem Biophys
Res Commun. 2009 Mar 20;380(4):823-4.
-
Zheng PP, Kros JM. Challenge of the gap between the current mania of cancer stem cells and
the therapeutic strategy for patients with cancer. Int J Cancer. 2009 Aug 26.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Circulation status of subintestinal vessels is
a sensitive parameter for monitoring suboptimal systemic circulation in experimental
zebrafish embryos. Cell Cycle. 2009 Nov 15;8(22):3782-3.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Images in cardiovascular medicine.
Functional cardiac phenotypes in zebrafish caldesmon morphants: a digital motion analysis.
Circulation. 2009 Oct 27;120(17):e145-6.
-
van den Bent MJ, Dubbink HJ, Sanson M, van der Lee-Haarloo CR, Hegi M, Jeuken JW,
Ibdaih A, Brandes AA, Taphoorn MJ, Frenay M, Lacombe D, Gorlia T, Dinjens WN, Kros
JM. MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant
PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor
Group Study 26951. J Clin Oncol. 2009 Dec 10;27(35):5881-6.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Different Patterns of Circulatory Shunting
in Zebrafish Caldesmon Morphants: A Digital Motion Analysis. Heart Lung Circ. 2009 Nov
12.
-
Mustafa, D. A., A. M. Sieuwerts, et al. (2010). "Overexpression of Colligin 2 in Glioma
Vasculature is Associated with Overexpression of Heat Shock Factor 2." Gene Regul Syst Bio
4: 103-107.
-
Verdijk, R. M., M. A. den Bakker, et al. (2010). "TP53 mutation analysis of malignant
peripheral nerve sheath tumors." J Neuropathol Exp Neurol 69(1): 16-26.
-
Zheng, P. P., E. Romme, et al. (2010). "Glut1/SLC2A1 is crucial for the development of the
blood-brain barrier in vivo." Ann Neurol 68(6): 835-844.
-
Zheng, P. P., L. A. Severijnen, et al. (2010). "Images. Different patterns of circulatory
shunting in zebrafish caldesmon morphants: a digital motion analysis." Heart Lung Circ
19(4): 251-252.
-
Verdijk, RM, den Bakker, MA, Dubbink, HJ, Hop, WCJ, Dinjens, WNM, Kros, JM. (2010)
“TP53 mutation analysis of malignant peripheral nerve sheath tumors”. J Neuropathol Exp
Neurol 69(1):16-26.
-
Zheng, P, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2010).
GLUT1/SLC2A1 is crucial for development of brain microvasculature with blood-brain
barrier properties in vivo: potential clinical implications. NEURO-ONCOLOGY, 12: 11-11
Suppl. 3 SEP 2010.
-
Zheng, PP, Severijnen, LA, Willemsen, R, Kros, JM. (2010). “Different Patterns of
Circulatory Shunting in Zebrafish Caldesmon Morphants: A Digital Motion Analysis”.
HEART LUNG AND CIRCULATION, 19 (4): 251-252.
-
Zheng, PP, Romme, E, van der Spek, PJ, Dirven, CMF, Willemsen, R (Willemsen, Rob);
Kros, JM. (2011). “Defect of development of ocular vasculature in Glut1/SLC2A1
knockdown in vivo” CELL CYCLE, 10 (11): 1871-1872.
-
Kros, JM. (2011). “Grading of Gliomas: The Road From Eminence to Evidence”. (2011).
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 70 (2):
101-109.
-
Zheng, PP,Romme, E,van der Spek, PJ, Dirven, CMF, Willemsen, R, Kros, JM. (2011).
“Glut1/SLC2A1 Is Crucial for the Development of the Blood-Brain Barrier In Vivo”.
ANNALS OF NEUROLOGY, 68 (6): 835-844.
-
Zheng, PP, van der Spek, PJ, Dirven, CM, Kros, JM. (2011) “Sinus venosus defect (SVD)
identified in zebrafish Glut1 morphants by video imaging”. INT J CARDIOL.
-
Zheng PP, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2011) HeNe
laser (633 nm)-coupled confocal microscope allows simulating magnetic resonance
imaging/computed tomography scan of the brain and eye: a noninvasive optical approach
applicable to small laboratory animals. ZEBRAFISH 8(2):83-5.
-
Zheng, PP, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2011) “Defect
of development of ocular vasculature in Glut1/SLC2A1 knockdown in vivo”. CELL CYCLE
10(11):1871-2.
Prof. Johan Kros 3
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Pathology; subdivision Neuropathology The Netherlands
Project Title:
Role of periostin in angiogenesis of glioma
Abstract:
The identification of angiogenesis-related proteins in glioma tumorigenesis is important for the
development of new anti-angiogenic therapies. In our previous work, we have identified
glioma-blood vessels-related proteins by combining laser-capture-microdissection with various
mass spectrometry techniques. More than 11 proteins show overexpression in glioma blood
vessels as compared to normal blood vessels in the brain. One of these is periostin, which is a
secreted adhesion-related protein that plays an important role in the genesis of various tumors.
There are several splice variants of periostin. The aim of this project is to further investigate the
expression of periostin and its splice variants in glioma blood vessels. First, the expression of
periostin will be studied by RT-PCR and immunohistochemistry / immunoblotting. These
experiments will include gliomas of various types and grades, in order to check in which stage of
angiogenesis overexpression begins. By using confocal scanning, periostin will be plotted to
particular cell types in the vessel walls (endothelial cells, pericytes, mural cells) in order to
investigate cell type specificity of expression. Finally, the effects of interference with the
expression will be investigated in cell culture experiments of endothelial cells, pericytes and
mural cells. In addition, the value of periostin as biomarker for the activity of the tumors will be
studied by measuring its concentrations in serum samples of patients with various stages of glial
tumor progression.
References:
1.
Mustafa et al. “Identification of glioma neovascularization-related proteins by using
MALDI-FTMS and nano-LC fractionation to microdissected tumor vessels. 2007:7:1147-57.
2.
Mustafa et al. “Expression sites of colligin 2 in glioma blood vessels” Brain Pathol
2010:2011(1):50-65.
3.
Mustafa et al. “Overexpression of colligin 2 in glioma vasculature is associated with
overexpression of heat shock factor 2”. Gene Regul Syst Bio 2010:4:103-7.
Requireme Background:
nts
of For this project a master in medicine, biomedical science, biochemistry or medical biology is
candidate: preferable.
Experience with standard techniques used in molecular biology is a preference.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Prof. Dr. Johan M. Kros, MD, PhD.
informatio j.m.kros@erasmusmc.nl
http://www.erasmusmc.nl/pathologie/research/kros/162476/
n:
Full Professor of Neuropathology
Chief, Neuropathology Division of the Dept. of Pathology
Chair, EORTC Neuropathology Panel
Chair, Dutch Neuropathological Society
Editorial Board WHO Classification of Tumours of the CNS
The research team of Prof. Kros consists of Dr. P. Zheng (Staff), Dr. D. Mustafa (postdoc), Dr. K.
Huizer (PhD student), Mr. van der Weiden (research technician). There is intensive collaboration
with Dr. R. Willemsen (Dept. of Clinical Genetics; head of zebrafish facility); Dr. T.M. Luider
(Dept. of Neurology, head of proteomics facility); Prof. J. Foekens (Dept. of Medical Oncology)
and the collaborators of the Dept. of Neurosurgery and Neuro-Oncology.
Research projects of the last 5 years:
PhD student position financed by the Department of Pathology of the Erasmus MC, resulting in
Thesis entitled “Low-molecular Caldesmon In Glioma Vasculature” by Dr. P. Zheng, defended on
February 16, 2005.
PI in project for PhD student financed by Mrace of the Erasmus MC, starting May 2005,
(collaboration with dr. T.M. Luider of the Dept. of Neuro-Oncology) resulted in thesis entitled
“Identifying proteins involved in glioma angiogenesis: a proteomics approach” by Dr. D. Mustafa,
defended on November 10, 2009.
Co-investigator in project entitled “The genotyping of anaplastic oligodendroglioma in a
prospective randomized clinical trial” by M.J. van den Bent and J.M. Kros, granted by the Dutch
Cancer Society, 2005/2006.
Co-investigator in project “MGMT gen promoter methylation in EORTC study 26951”. M.J. van
den Bent, J.M.Kros, W.N.M. Dinjens. KWF Translational Research Grant EMCR 2007-3932.
Co-investigator in project “Evaluation of l-caldesmon as biomarker for brain tumor monitoring”
by T.M.Luider, P.A.E. Sillevis Smitt, J.M. Kros. Zon MW; 2006-2010.
PI in postdoc project for KWF (Dutch cancer society) granted project:”Towards evidence-based
pathology diagnosis of gliomas. A panel review combining pathological and molecular parameters
on EORTC trials 26951 and 26882”. Jan 1, 2011- 2013.
PI in PhD KWF (Dutch cancer Society) granted project: “Identification and utilization of
pathways involved in brain metastasis of common cancers”. July 1, 2011-2015.
List of recent publications:
-
Hegi ME, Diserens A-C, Gorlia T, Hamou M-F, de Tribolet N, Weller M, Kros JM,
Hainfellner JA, Mason WP, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross G,
Janzer R, Stupp R. MGMT Gene Silencing and Response to Temozolomide in Glioblastoma.
New Engl J Med 352:997-1003, 2005.
-
Kros JM, Gorlia T, Kouwenhoven MC, Kouwenhoven MC, Zheng PP, Collins VP,
Figarella-Branger D, Giangaspero F, Giannini C, Mohktari K, Mork SJ, Paetau A,
Reifenberger G, van den Bent MJ. Panel review of anaplastic oligodendroglioma from
European Organization For Research and Treatment of Cancer Trial 26951: Assessment of
consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. J
Neuropathol Exp Neurol 66:545-51, 2007.
-
Mustafa DA, Burgers PC, Dekker LJ, Charif H, Titulaer MK, Sillevis Smitt PA, Luider TM,
Kros JM. Identification of glioma neovascularization-related proteins by using
MALDI-FTMS and nano-LC fractionation to microdissected tumor vessels. Mol Cell
Proteomics 6:1147-57, 2007.
-
Zheng PP, Hop WC, Luider TM, Sillevis Smitt PA, Kros JM. Increased levels of circulating
endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with
gliomas. Ann Neurol 62:40-8, 2007.
-
Zheng PP, Weiden M, Sillevis Smitt PA, Luider TM, Kros JM. Hela /-CaD Undergoes a DNA
Replication-Associated Switch in Localization from the Cytoplasm to the Nuclei of
Endothelial Cells/Endothelial Progenitor Cells in Human Tumor Vasculature. Cancer Biol
Ther 6:886-90, 2007.
-
Zheng PP, van der Weiden M, Kros JM. Hela l-CaD is implicated in the migration of
endothelial cells/endothelial progenitor cells in human neoplasms. Cell Adhesion & Migration
1(2):1-8, 2007.
-
Kros JM, van der Weiden M, Zheng PP, Hop WC, van den Bent MJ, Kouwenhoven CM.
Intratumoral distribution of 1p loss in oligodendroglial tumors. J Neuropathol Exp Neurol
2007; 66(12):1118-23.
-
van den Bent MJ, Kros JM. Predictive and prognostic markers in Neuro-Oncology. J
Neuropathol Exp Neurol 2007; 66(12):1074-1081.
-
Mustafa D, Kros JM, Luider T. Combining laser capture microdissection and proteomics
techniques. Methods Mol Biol 2008 428:159-78.
-
Mustafa D, van der Weiden M, Luider T, Kros JM. Expression sites of colligin 2 in glioma
blood vessels. Brain Pathol 2008, Dec 5.
-
Zheng P, Severijnen LA, Willemsen R, Kros JM. Caldesmon is essential for cardiac
morphogenesis and function: in vivo study using a zebrafish model. Biochem Biophys Res
Commun 2009 2;378(1):37-40.
-
Zheng P, Severijnen L-A, van der Weiden M, Willemsen R, Kros JM. A crucial role of
caldesmon in vascular development in vivo. Cardiovascular Res 2008 Nov 23.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Reduction of caldesmon expression
induces apoptosis and causes disassembly of the sarcomeric protein complex in
cardiomyocytes in vivo. Cell Cycle. 2009 Jan 15;8(2):325-6.
-
Zheng PP, Severijnen LA, van der Weiden M, Willemsen R, Kros JM. Cell proliferation and
migration are mutually exclusive cellular phenomena in vivo: implications for cancer
therapeutic strategies. Cell Cycle. 2009 Mar 15;8(6):950-1.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Haemoglobin staining for in vivo
portraying of functional vasculature in experimental zebrafish embryos. Biochem Biophys
Res Commun. 2009 Mar 20;380(4):823-4.
-
Zheng PP, Kros JM. Challenge of the gap between the current mania of cancer stem cells and
the therapeutic strategy for patients with cancer. Int J Cancer. 2009 Aug 26.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Circulation status of subintestinal vessels is
a sensitive parameter for monitoring suboptimal systemic circulation in experimental
zebrafish embryos. Cell Cycle. 2009 Nov 15;8(22):3782-3.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Images in cardiovascular medicine.
Functional cardiac phenotypes in zebrafish caldesmon morphants: a digital motion analysis.
Circulation. 2009 Oct 27;120(17):e145-6.
-
van den Bent MJ, Dubbink HJ, Sanson M, van der Lee-Haarloo CR, Hegi M, Jeuken JW,
Ibdaih A, Brandes AA, Taphoorn MJ, Frenay M, Lacombe D, Gorlia T, Dinjens WN, Kros
JM. MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant
PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor
Group Study 26951. J Clin Oncol. 2009 Dec 10;27(35):5881-6.
-
Zheng PP, Severijnen LA, Willemsen R, Kros JM. Different Patterns of Circulatory Shunting
in Zebrafish Caldesmon Morphants: A Digital Motion Analysis. Heart Lung Circ. 2009 Nov
12.
-
Mustafa, D. A., A. M. Sieuwerts, et al. (2010). "Overexpression of Colligin 2 in Glioma
Vasculature is Associated with Overexpression of Heat Shock Factor 2." Gene Regul Syst Bio
4: 103-107.
-
Verdijk, R. M., M. A. den Bakker, et al. (2010). "TP53 mutation analysis of malignant
peripheral nerve sheath tumors." J Neuropathol Exp Neurol 69(1): 16-26.
-
Zheng, P. P., E. Romme, et al. (2010). "Glut1/SLC2A1 is crucial for the development of the
blood-brain barrier in vivo." Ann Neurol 68(6): 835-844.
-
Zheng, P. P., L. A. Severijnen, et al. (2010). "Images. Different patterns of circulatory
shunting in zebrafish caldesmon morphants: a digital motion analysis." Heart Lung Circ
19(4): 251-252.
-
Verdijk, RM, den Bakker, MA, Dubbink, HJ, Hop, WCJ, Dinjens, WNM, Kros, JM. (2010)
“TP53 mutation analysis of malignant peripheral nerve sheath tumors”. J Neuropathol Exp
Neurol 69(1):16-26.
-
Zheng, P, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2010).
GLUT1/SLC2A1 is crucial for development of brain microvasculature with blood-brain
barrier properties in vivo: potential clinical implications. NEURO-ONCOLOGY, 12: 11-11
Suppl. 3 SEP 2010.
-
Zheng, PP, Severijnen, LA, Willemsen, R, Kros, JM. (2010). “Different Patterns of
Circulatory Shunting in Zebrafish Caldesmon Morphants: A Digital Motion Analysis”.
HEART LUNG AND CIRCULATION, 19 (4): 251-252.
-
Zheng, PP, Romme, E, van der Spek, PJ, Dirven, CMF, Willemsen, R (Willemsen, Rob);
Kros, JM. (2011). “Defect of development of ocular vasculature in Glut1/SLC2A1
knockdown in vivo” CELL CYCLE, 10 (11): 1871-1872.
-
Kros, JM. (2011). “Grading of Gliomas: The Road From Eminence to Evidence”. (2011).
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 70 (2):
101-109.
-
Zheng, PP,Romme, E,van der Spek, PJ, Dirven, CMF, Willemsen, R, Kros, JM. (2011).
“Glut1/SLC2A1 Is Crucial for the Development of the Blood-Brain Barrier In Vivo”.
ANNALS OF NEUROLOGY, 68 (6): 835-844.
-
Zheng, PP, van der Spek, PJ, Dirven, CM, Kros, JM. (2011) “Sinus venosus defect (SVD)
identified in zebrafish Glut1 morphants by video imaging”. INT J CARDIOL .
-
Zheng PP, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2011) HeNe
laser (633 nm)-coupled confocal microscope allows simulating magnetic resonance
imaging/computed tomography scan of the brain and eye: a noninvasive optical approach
applicable to small laboratory animals. ZEBRAFISH 8(2):83-5.
-
Zheng, PP, Romme, E, van der Spek, PJ, Dirven, CM, Willemsen, R, Kros, JM. (2011) “Defect
of development of ocular vasculature in Glut1/SLC2A1 knockdown in vivo”. CELL CYCLE
10(11):1871-2.
Prof. John Foekens 1
School/De
partment:
Erasmus University Medical Center Rotterdam Department of Medical Oncology
(Post-graduate school of Molecular Medicine (www.molmed.nl)) The Netherlands
Project Title:
Complete characterization of circulating tumor cells at the single cell level
Abstract:
Metastases can differ greatly from primary tumor tissue in terms of
genetic characteristics. However, taking biopsies from metastases in
patients is an invasive procedure and is frequently not possible due to the lack of accessible
lesions. Circulating tumor cells (CTCs) are found in the peripheral blood of patients and can thus
be regarded as “liquid biopsies” of metastasizing cells.
Our group has broad experience with CTCs, has already demonstrated the feasibility of
performing extensive molecular characterization of CTCs from breast and colon cancer patients at
both the mRNA and microRNA level, and is now ready to enter the next level: complete
characterization of single CTCs at both the RNA and genomic DNA level with state of the art
techniques such as DNA and RNA sequencing. Understanding the genetic mechanisms underlying
the variation in gene expression in CTCs and identifying those CTCs that are responsible for the
development of metastases and how to attack these is our ultimate goal. It is anticipated that this
approach will improve our understanding of the diversity within CTCs and aid to currently
available prognostic and predictive models.
After an extensive introduction period to get familiar with the field of CTCs and the state-of-the
art techniques available at our university, the student will start with the optimization of genomic
and transcriptome analyses at the single cell level. In the second part of the project the acquired
knowledge will be used to identify relevant biological pathways and putatively new
–patient-tailored- drug targets.
For this, we are looking for an eager student who would like to join our very active CTC group,
currently composed of 10 persons [at least one other PhD student and several technicians,
scientific researchers and medical doctors].In addition, the student will get supervision from
several employees of our 'Translational Cancer Genomics and Proteomics' department.
requireme Background: Molecular Biology
nts
of Master degree: Yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score) Other: Affinity for genomics research
Supervisor Supervisor: Prof. Dr. J.A. Foekens E-mail: j.foekens@erasmusmc.nl
informatio Co-Supervisor: Dr. A.M. Sieuwerts E-mail: a.sieuwerts@erasmusmc.nl
Department website: http://www.erasmusmc.nl/interne_oncologie/research/
n:
List of recent publications:
1.
Sieuwerts, A.M., Mostert, B., Bolt-de Vries, J., Peeters, D., de Jongh, F.E., Stouthard,
J.M., Dirix, L.Y., van Dam, P.A., Van Galen, A., de Weerd, V. et al. (2011) mRNA and
microRNA Expression Profiles in Circulating Tumor Cells and Primary Tumors of
Metastatic Breast Cancer Patients. Clin Cancer Res, 17, 3600-3618.
2.
Mostert, B., Sieuwerts, A.M., Martens, J.W. and Sleijfer, S. (2011) Diagnostic
applications of cell-free and circulating tumor cell-associated miRNAs in cancer
patients. Expert Rev Mol Diagn, 11, 259-275.
3.
Kraan, J., Sleijfer, S., Strijbos, M.H., Ignatiadis, M., Peeters, D., Pierga, J.Y., Farace,
F., Riethdorf, S., Fehm, T., Zorzino, L. et al. (2010) External quality assurance of
circulating tumor cell enumeration using the CellSearch((R)) system: a feasibility
study. Cytometry B Clin Cytom, 80, 112-118.
4.
Mostert, B., Kraan, J., Bolt-de Vries, J., van der Spoel, P., Sieuwerts, A.M., Schutte,
M., Timmermans, A.M., Foekens, R., Martens, J.W., Gratama, J.W. et al. (2010)
Detection of circulating tumor cells in breast cancer may improve through enrichment
with anti-CD146. Breast Cancer Res Treat, 127, 33-41.
5.
Sieuwerts, A.M., Kraan, J., Bolt-de Vries, J., van der Spoel, P., Mostert, B., Martens,
J.W., Gratama, J.W., Sleijfer, S. and Foekens, J.A. (2009) Molecular characterization
6.
7.
of circulating tumor cells in large quantities of contaminating leukocytes by a
multiplex real-time PCR. Breast Cancer Res Treat, 118, 455-468.
Sieuwerts, A.M., Kraan, J., Bolt, J., van der Spoel, P., Elstrodt, F., Schutte, M.,
Martens, J.W., Gratama, J.W., Sleijfer, S. and Foekens, J.A. (2009) Anti-epithelial cell
adhesion molecule antibodies and the detection of circulating normal-like breast tumor
cells. J Natl Cancer Inst, 101, 61-66.
Mostert, B., Sleijfer, S., Foekens, J.A. and Gratama, J.W. (2009) Circulating tumor
cells (CTCs): Detection methods and their clinical relevance in breast cancer. Cancer
Treat Rev, 35, 463-474.
Prof. John Foekens 2
School/Depar
tment:
Erasmus University Medical Center Rotterdam Department of Medical Oncology
(Post-graduate school Molecular Medicine (www.molmed.nl)) The Netherlands
Project Title:
Understanding aggressiveness of triple-negative breast cancer
Abstract:
Triple negative breast cancers (TNBCs) have a poor prognosis and have limited treatment options
as they lack receptors for currently available targeted treatments including anti-estrogens and
HER2-targeting compounds. Using various genomics and proteomics approaches, we have
identified 564 mRNAs, 20 miRNAs, and 188 protein species associated with aggressiveness of
TNBC. State-of-the-art bioinformatic analysis, also employing publicly available knowledge, has
revealed that, amongst others, BMP/TGF-β signaling, specific metabolic pathways and altered
immune responses contribute to aggressiveness of TNBC.
The aim of this PhD proposal is to functionally validate the pathways predicted to be associated
aggressiveness of TNBC.
For this, using siRNA SMART pools, miRNA mimics and pharmacological inhibitors, the key
molecules implicated in the predicted pathways will be modulated in TNBC cell lines to
determine whether they specifically block the predicted signaling pathways, and, if so, how this
affects end-points related to aggressiveness such as cell migration, cell survival, senescence,
autophagy, DNA repair, etc. Secondly, key reporter molecules representing the activated state of a
particular signaling pathway will be studied by immuno-histochemistry on tissue microarrays
containing 300 cases with TNBC, and their expression will be related to metastasis-free survival.
This will establish if a surrogate marker of a predicted pathway has prognostic value further
implying this pathways is related to aggressiveness of TNBC. Finally, to provide in vivo evidence
for a particular pathway in TNBC aggressiveness, we will stably block using shRNA-based gene
knock-down the pathway in a few suitable TNBC cell lines and study the effect of this on their
growth and/or metastatic capacity when orthotopically transplanted into nude mice. We anticipate
that this project will provide solid evidence for one or more biochemical pathways being related
to aggressiveness in TNBC.
Keywords: breast cancer, BMP/metabolic signaling, bioinformatics
Requirements
of candidate:
Background: Molecular biology;
Master degree: Yes;
IELTS Grade: 7.0 (min. 6.0 per sub-score) OrTOEFL: 100 (min. 20 per sub-score)
Other: Affinity for experimental in vitro/in vivo studies and for bioinformatics.
Supervisor
information:
Supervisor: Prof. Dr. J.A. Foekens E-mail: j.foekens@erasmusmc.nl
Co-Supervisor: Dr. J.W. Martens E-mail: j.martens@erasmusmc.nl
Research interests: Molecular mechanisms of breast cancer aggressiveness
Website: Laboratory of Breast Cancer Genomics and Proteomics
http://www.erasmusmc.nl/interne_oncologie/research/ResearchPrograms/cancer_genomics_and_p
roteomics/groep_martens/
Published articles:
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Martens%20JW%22%5BAuthor%5D
Prof. John Foekens 3
School/Dep Erasmus University Medical Center Rotterdam Department of Medical Oncology
Laboratory of Breast Cancer Genomics and Proteomics
artment:
(Post-graduate school of Molecular Medicine (www.molmed.nl)) The Netherlands
Project
Title:
Abstract:
Development of a serum protein marker assay for early detection of breast cancer using a
combined tissue and serum proteomics approach
With an incidence rate of 1:8, breast cancer is the leading cause of cancer-related deaths in the
Netherlands. Each year, 13,000 new patients are diagnosed, of which 3,000 die. Breast cancer is
currently mainly detected through physical examination, clinical symptoms or mammography.
The limitation of these detection methods is that 30-40% of the patients already have metastastic
disease at first detection. MRI can detect cancers more frequently at younger age and at a
favorable stage, but has a higher false-positive rate than traditional methods, and is costly.
Therefore, new, sensitive and easily applicable methods are necessary to improve early detection
of breast cancer. We propose to develop a sensitive serum protein marker assay that can improve
early detection of breast cancer. Such an assay will be a strong tool for guiding mammography
and MRI, thereby increasing detection rates and as a consequence reducing breast cancer
mortality.
In a preliminary study, we have used a tissue proteomics approach to identify protein markers for
early detection of breast cancer. We have performed laser capture microdissection to isolate
epithelial cells from normal, benign, pre-invasive ductal carcinoma in situ, and invasive breast
cancer tissue. Protein extracts were prepared for subsequent nanoscale liquid chromatography
(nLC) – Orbitrap mass spectrometry (MS) analysis. Comparative proteome analysis revealed that
a significant number of differentially abundant proteins could be identified between normal,
benign, pre-invasive, and invasive breast tissue.
In the current project, we propose to verify the presence of differentially abundant tissue protein
markers in matching patient serum samples. A targeted proteomics approach will be used to
sensitively measure the presence of marker proteins in serum, and quantitative MS assays will be
developed to verify differential abundance of these markers. Once a panel of differentially
abundant protein markers is verified in serum, the clinical relevance will be validated in a larger
and independent set of ~250 serum samples available within our institute. In addition, we have the
availability of ~1,000 serum samples through our collaborator in Denmark, prof. dr. N. Brünner,
for external validation.
In the final step of the study, functional genomics and proteomics studies will be performed to
unravel molecular mechanisms underlying breast cancer development. For these studies, a large
panel of breast cancer cell lines en xenograft models is available.
Requireme Background: (Medical/Molecular) Biology, Biochemistry, Chemistry
nts
of Master degree: yes
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Other: affinity with proteomics research, such as HPLC/ mass spectrometry and/or
bioinformatics.
Supervisor
informatio
n:
Supervisor: Prof. Dr. J.A. Foekens E-mail: j.foekens@erasmusmc.nl
Co-Supervisor: Dr. A.Umar E-mail: a.umar@erasmusmc.nl
Website:
http://www.erasmusmc.nl/interne_oncologie/research/ResearchPrograms/cancer_genomics_and_p
roteomics/
List of recent publications:
R. B. H. Braakman, T. M. Luider, J.W.M. Martens, J. A. Foekens, and A. Umar. Laser capture
microdissection applications in breast cancer biomarker discovery. In Laser Capture
Microdissection: methods and applications 755:143-54 (2011), Ed. G. Murray, Humana Press Inc.,
NJ.
A. Umar, H. Kang, A.M. Timmermans, M.P. Look, M.E. Meijer-van Gelder, N. Jaitly, M. Den
Bakker, J.W.M. Martens, T.M. Luider, J.A. Foekens, L. Paša-Tolić. Identification of a putative
protein-profile associating with tamoxifen therapy-resistance in breast cancer. Molecular &
Cellular Proteomics , 8 (6):1278-1294 (2009). IF: 8.8
A. Umar, M. Jaremko, P. C. Burgers, T. M. Luider, J. A. Foekens, L. Paša-Tolić. High-throughput
proteomics of breast carcinoma cells: a focus on FTICR MS. Exp Rev Proteomics 5(3):445-55
(2008). IF: 3.5
A. Umar, T.M. Luider, J.A. Foekens, L. Paša-Tolić. NanoLC-FTICR MS improves proteome
coverage attainable for ~3,000 laser microdissected breast carcinoma cells. Proteomics 7:323-329
(2007). IF: 5.2
A. Umar, J. C. Dalebout, A. M. Timmermans, J. A. Foekens, T. M. Luider. Method optimisation
for peptide profiling of microdissected breast carcinoma tissue by matrix-assisted laser
desorption/ionisation-time of flight and matrix-assisted laser desorption/ionisation-time of
flight/time of flight-mass spectrometry. Proteomics 5: 2680-2688 (2005). IF: 5.2
Prof. Meijering
School/De
partment:
Erasmus University Medical Center Rotterdam
Departments of Medical Informatics and Radiology
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl
The Netherlands
Project
Title:
Abstract:
Advanced Algorithms for Cell Tracking and Motion Analysis in Microscopy Movies
Cells are the fundamental units of biological life. The proliferation, differentiation, and migration
of cells are essential processes in the conception, development, and maintenance of any living
organism. These processes also play a crucial role in the onset and progression of many diseases.
It is very important to understand how these processes work in order to develop effective drugs.
Live cell imaging experiments produce enormous amounts of image data (3D/4D/5D) containing
much more information than can be analyzed by humans. Computerized image analysis can help
to take full advantage of the data in an efficient and reproducible manner. An important task in
many experiments is the tracking of large numbers of cells and the automated analysis of their
(morpho)dynamic behavior.
The goal of this project is to develop and test advanced high-throughput image analysis
algorithms to automatically track and analyze the motion and shape changes of large numbers of
moving cells in microscopy movies.
This is a challenging problem, since the image quality is often poor (low contrast and high noise
levels), the density of cell populations may vary a lot due to cell division and cells entering or
leaving the field of view, and cells may touch each other without showing sufficient image
contrast.
Existing algorithms for cell tracking are usually based on a two-step approach: (1) detection and
segmentation of cells in each image of a movie, and (2) linking the detected cells between frames.
In this project, the goal is to develop an integrated and probabilistic method for this.
Requireme Background:
nts
of Experience with biomedical image analysis is an advantage Experience with computer
candidate: programming (Java or C++), strong theoretical skills, communication skills (English), and the
ability to work in a multi-disciplinary team (involving both computer scientists and biologists) are
required
Master degree: MSc degree in mathematics, physics, electrical engineering, biomedical
engineering, computer science, or a related field.
IELTS: 7.0 (min. 6.0 per sub-score)
Supervisor Supervisor: Ass. Prof. dr. E. Meijering, Associate Professor of Bio-image Analysis
informatio E-mail: meijering@imagescience.org
Website: http://www.imagescience.org/meijering/
n:
Recent publication list:
1. E. Meijering, O. Dzyubachyk, I. Smal (2011). Methods for Cell and Particle Tracking.
Methods in Enzymology: Live Cell Imaging, in press.
2. O. Dzyubachyk, J. Essers, W. A. van Cappellen, C. Baldeyron, A. Inagaki, W. J. Niessen, E.
Meijering (2010). Automated Analysis of Time-Lapse Fluorescence Microscopy Images:
From Live Cell Images to Intracellular Foci. Bioinformatics 26(19):2424-2430.
3. E. Meijering, O. Dzyubachyk, I. Smal, W. A. van Cappellen (2009). Tracking in Cell and
Developmental Biology. Seminars in Cell and Developmental Biology 20(8):894-902.
4. I. Smal, K. Draegestein, N. Galjart, W. Niessen, E. Meijering (2008). Particle Filtering for
Multiple Object Tracking in Dynamic Fluorescence Microscopy Images: Application to
Microtubule Growth Analysis. IEEE Transactions on Medical Imaging 27(6):789-804.
Prof. Peter Patka
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Trauma Surgery and Emergency The Netherlands
Project Title:
Medical Management of Major Incidents and Disasters
Abstract:
The prevalence of disasters, mass casualty situations and public service disruptions (including
terrorism, biological and chemical terrorism, war, tsunamis, earthquakes, hurricanes, floods,
wildfires, volcanoes and major power grid disruptions) is increasing.
Major accidents and disasters are connected to an increase of mobility (mass transportation: train,
bus, ships and airplane) and to volume concentration of the population at one place (exhibitions,
cultural- and sport events). Additionally, we are also facing an increasing number of accidents
involving hazardous materials.
The effects of all of these events on people, animals, the environment, physical structures and
public infrastructure have been immense. This has brought increased attention to our public
safety, emergency medical services (EMS) and public health systems in terms of disaster
preparedness. The need for a highly organized disaster preparedness infrastructure and individuals
with expertise in this area has become readily apparent to the government and private sector.
Disaster emergency planning and management has become an expanding area of study in the
fields of medicine, emergency medical services, public safety, mental health, public health and the
military.
In these exceptional situations a considerable number of human beings can be involved in an
accident. Prehospital and early hospital (ED) management of victims is a matter of preparedness,
planning and capacity. This ability to cope with these problems will be a part of this research
project.
The objective of this PhD research program is to assess the impact of a major accident on
prehospital and hospital functions and services. Hospitals functioning in a post-disaster
environment must provide emergency medical care related to the event, in addition to providing
standard community health services. This study will focus on damage to both structural and
nonstructural components, as well as to utility services. The track and trace management of a
disaster victims will be part of this project.
Requireme Background: Interested in emergency medicine, major accidents and disasters. MD and public
nts
of health.
candidate: Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisor: Prof. dr. P. Patka E-mail: p.patka@erasmusmc.nl
informatio List of recent publications:
Van Harten SM, Welling L, Perez RSGM, Patka P, Henny P, Kreis RW. Interhospital Transportation of
n:
Mass Burn Casualties. Eur J Trauma Emerg Surg 2007;33(2):176-182.
Ringburg AN, Spanjersberg WR, Frankema SPG, Steyerberg EW, Patka P, Schipper IB. HEMS
Assistance: Impact on On-Scene Times. J Trauma 2007;63(2):258-262.
Schepers T, van Lieshout EMM, van Ginhoven TM, Heetveld MJ, Patka P. Current concepts in the
treatment of intra-articular calcaneal fractures: results of a nationwide survey. Int Orthop
2008;32(5):711-715.
Siebenga J, Leferink VJ, Segers MJ, Elzinga MJ, Bakker FC, Ten DH, Rommens PM, Patka P. A
prospective cohort study comparing the VAS spine score and Roland-Morris disability questionnaire in
patients with a type A traumatic thoracolumbar spinal fracture. Eur Spine J 2008;17(8):1096-1100.
Van der Velden MWA, Ringburg AN, Bergs EA, Steyerberg EW, Patka P, Schipper IB. Prehospital
interventions: time wasted or time saved? An observational cohort study of management in initial trauma
care. Emerg Med J 2008;25(7):444-449.
Knops SP, van Riel MPJM, Goossens RHM, van Lieshout EMM, Patka P, Schipper IB.
Measurements of the exerted pressure by pelvic circumferential compression devices.
Open Orthop J 2009;3:213-218.
Ringburg AN, Buljac M, Stolk EA, van Lieshout EMM, van Beeck EF, Patka P, Schipper IB.
Willingness to Pay for Lives Saved by Helicopter Emergency Medical Services.
Prehosp Emerg Care 2009;13(1):37-43.
Ringburg AN, de Ronde G, Thomas SH, van Lieshout EMM, Patka P, Schipper IB.
Validity of Helicopter Emergency Medical Services Dispatch Criteria for Traumatic Injuries; A systematic
review.
Prehosp Emerg Care 2009;13(1):28-36.
Ringburg AN, Polinder S, Meulman TJ, Steyerberg EW, van Lieshout EMM, Patka P, van Beeck EF,
Schipper IB.
Physician staffed Helicopter Emergency Medical Services in the Netherlands: a cost effectiveness
analysis.
Br J Surg 2009:96(11);1365–1370.
Ringburg AN, Thomas SH, Steyerberg EW, van Lieshout EMM, Patka P, Schipper IB.
Lives saved by Helicopter Emergency Medical Services - An Overview of Literature.
Air Med J 2009;28(6):298-302.
Schepers T, Patka P.
Treatment of displaced intra-articular calcaneal fractures by ligamentotaxis: current concepts review.
Arch Orthop Trauma Surg 2009;129:1677–1683.
Spanjersberg WR, Knops SP, Schep NWL, van Lieshout EMM, Patka P, Schipper IB.
Effectiveness and complications of Pelvic Circumferential Compression Devices in patients with unstable
pelvic fractures - A systematic review of literature.
Injury, Int. J. Care Injured 2009;40:1031–1035.
Varin DSE, Ringburg AN, van Lieshout EMM, Patka P, Schipper IB.
Accurary of diagnostic modalities in penetrating torso injuries.
Eur J Emerg Med 2009;16(6):305-311.
De Haan J, Schep NWL, Tuinebreijer WE, Patka P, Den Hartog D.
Simple elbow dislocations: a systematic review of the literature.
Arch Orthop Trauma Surg 2010;130(2):241-249.
Den Hartog D, Tuinebreijer WE, Oprel PP, Patka P
Acute traumatic abdominal wall hernia
Hernia 2010, in press (Accepted April 2010); E-pub 04 May 2010
Hartholt KA, Van Beeck EF, Polinder S, Van der Velde N, Van Lieshout EMM, Panneman MJM, Van der
Cammen TJM, Patka P.
Societal consequences of falls in the older population: injuries, healthcare costs and long term reduced
quality of life.
J Trauma 2010, in press (Accepted August 2010); E-Pub November 1, 2010
Hartholt KA, Van Lieshout EMM, Thies WC, Patka P, Schipper IB.
IntraOsseous Devices – a Randomized Controlled Trial comparing three intraosseous devices.
Prehosp Emerg Care 2010;14(1):6-13.
artholt KA, Van der Velde N, Looman CWN, Panneman MJM, Van Beeck EF, Patka P, Van der Cammen
TJM.
Adverse Drug Reactions Related Hospital Admissions in Persons Aged 60 Years and over, The
Netherlands, 1981–2007: Less Rapid Increase, Different Drugs.
PLoS ONE 2010;5(11): e13977.
Hartholt KA, Van der Velde N, Looman CWN, Van Lieshout EMM, Van Beeck EF, Patka P, Van der
Cammen TJM.
Trends in fall-related hospital admissions in older persons in the Netherlands.
Arch Intern Med 2010;170(10):905-911.
Knops SP, Van Lieshout EMM, Spanjersberg WR, Patka P, Schipper IB.
Randomized clinical trial comparing pressure characteristics of Pelvic Circumferential Compression
Devices.
Injury 2010, in press (Accepted September 2010); E-Pub October 8, 2010
Knops SP, van Riel MPJM, Goossens RHM, Van Lieshout EMM, Patka P, Schipper IB.
Measurements of the exerted pressure by pelvic circumferential compression devices.
Open Orthop J 2010;4:101-106.
Ringburg AN, Polinder A, Van Ierland MCP, Steyerberg EW, Van Lieshout EMM, Patka P, Van Beeck EF,
Schipper IB.
Prevalence and prognostic factors of disability after major trauma.
J Trauma 2010, in press (Accepted August 2010); E-Pub November 1, 2010.
Schepers T, Kieboom BCT, Van Diggele P, Patka P, Van Lieshout EMM.
Plantar pressure analysis and quality of life after operative and conservative treatment of Lisfranc
fracture dislocations.
Foot Ankle Int 2010;31(10):857-864
Wigman LD, Van Lieshout EMM, De Ronde G, Patka P, Schipper IB.
Trauma-related dispatch criteria for Helicopter Emergency Medical Services in Europe.
Injury 2010;41(7):1022-1030.
Knops SP, Schep NWL, Spoor CW, van Riel MPJM, Spanjersberg WR, Kleinrensink GJ, van Lieshout
EMM, Patka P, and Schipper IB. Comparison of Three Different Pelvic Circumferential Compression
Devices: A Biomechanical Cadaver Study" J Bone Joint Surg Am 2011;93:1-11
Folmer W, Lammers W, Mulligan T, Van Lieshout EMM, Patka P, Xu Z, Lu Y, Den Hartog D. Patient
Demographics in Acute Care Surgery at the Ruijin Hospital in Shanghai. ISRN Surgery 2011, Article ID
801404, 8 pages.
Lammers W, Folmer W, Van Lieshout EMM, Mulligan T, Christiaanse JC, Den Hartog D, Tong J, Lu Y,
Patka P. Demographic Analysis of Emergency Department Patients at
the Ruijin Hospital, Shanghai. ISRN Surgery 2011, Article ID 748274, 5 pages.
Prof. Ronald de Krijger
School/De
partment:
Erasmus University Medical Center Rotterdam Department of Medicine
The Netherlands
Project Title:
Molecular Pathogenesis of Pheochromocytomas and Paragangliomas
Abstract:
Pheochromocytomas (PCC) and paragangliomas (PGL) are tumors in the adrenal gland and in the
head and neck that may cause severe health problems. In addition, they are frequently hereditary
and occur in the context of several syndromes. There are now 10 candidate genes known that may
cause these tumors and related syndromes, which makes genetic testing cumbersome and
expensive. In addition, there is no good therapy for patients with malignant forms of these tumors,
which represent 10-20% of the entire group.
Our research is focused on: 1. the differences between benign and malignant PCC and PGL; 2. the
molecular pathogenesis of PCC and PGL with the aim to develop more effective treatment
strategies; 3. to improve diagnostic procedures with respect to the genetic background of tumors.
The work is carried out in the Dept. of Pathology, using standard immunohistochemical
techniques and advanced molecular techniques, including PCR, direct sequencing, MLPA,
array-CGH, gene expression profiling and full genome sequencing. Research is done in
collaboration with clinical departments in the Erasmus MC (Surgery, Endocrinology, Clinical
Genetics) and in the context of a recently approved European FP7 project with 14 partners from
most European countries (project description available).
Requireme Background: candidates must be fluent in English, have at least one year of basic laboratory
nts
of experience, preferably in a molecular biology setting, and must hold a Master degree
candidate: Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score)orTOEFL: 100 (min. 20 per sub-score)
Supervisor Prof. dr. R.R. De Krijger
informatio E-mail: r.dekrijger@erasmusmc.nl
Website: http://www.erasmusmc.nl/pathologie/research/dekrijger/
n:
Prof. Teun van Gelder 1
School/De
partment:
Erasmus University Medical Center Rotterdam
Departments of Hospital Pharmacy and Internal Medicine
Clinical Pharmacology Unit The Netherlands
Project
Title:
Abstract:
Monitoring monoclonal antibody concentrations and neutralizing antibodies as a means to
individualize pharmacotherapy.
Initial therapeutic monoclonal antibodies were simple murine analogues, which contributed to the
early lack of success. It has since been shown that these antibodies have a short half-life in vivo
(due to immune complex formation). Chimeric and humanized antibodies have generally replaced
murine antibodies in modern therapeutic antibody applications. Although chimeric and humanized
antibodies have reduced immunogenicity and increased serum half-life it is now clear that
formation of antidrug antibodies is associated with low to absent serum drug levels and a
diminished treatment response, or even exacerbation of the underlying disease.
In current daily clinical practice in patients treated with monoclonal antibodies no monitoring of
plasma concentrations and neutralizing antibodies is performed. A proportion of patients may
however have plasma concentrations that are above the therapeutic window, and in those patients
dose reductions may allow considerable savings in drug cost. Other patients may have developed
neutralizing antibodies, resulting in lower or absent concentrations of the drug and lower
likelihood of minimal disease activity or clinical remission.
In this project we aim to monitor plasma concentrations of monoclonal antibodies, as well as
neutralizing antibodies before administration of a next dose. Furthermore clinical outcome data
will be collected. The minimal effective plasma concentrations and the effect of neutralizing
antibodies will be evaluated. Pharmacokinetic modeling may allow development of improved
tapering regimens and support individual dose reductions, while preventing occurrence of
exacerbations. Studies in patients suffering from several conditions, such as inflammatory bowel
disease, rheumatoid arthritis, psoriasis, and multiple sclerosis are anticipated.
Requireme Background: The candidate is a student in pharmacy or medicine, and should have an interest in
nts
of both clinical research and analytical methods.
candidate: Master degree: Pharmacy or Medicine.
IELTS Grade: 7 (min. 6.0 per sub-score)or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Professor dr T. van Gelder, MD PhD
informatio Professor in Clinical Pharmacology
Erasmus Medical Center Rotterdam
n:
The Netherlands
E-mail: t.vangelder@erasmusmc.nl
Website:http://www.erasmusmc.nl/internationalization/projects/?lang=en
http://nl.linkedin.com/pub/teun-van-gelder/b/436/820
List of recent publications:
1. van Gelder T et al. Comparing Mycophenolate Mofetil Regimens for De Novo Renal
Transplant Recipients: The Fixed-Dose Concentration-Controlled (FDCC) Trial.
Transplantation. 2008;86:1043-51
2. van Gelder T et al. TDM for mycophenolic acid at no extra cost. Transplantation. 2010
May 27;89(10):1176-7.
3. Borra LC et al. High within-patient variability in the clearance of tacrolimus is a risk
factor for poor long-term outcome after kidney transplantation. Nephrol Dial Transplant.
2010 Aug;25(8):2757-63.
4. de Winter BC et al. Nonlinear relationship between mycophenolate mofetil dose and
mycophenolic acid exposure: implications for therapeutic drug monitoring. Clin J Am
Soc Nephrol. 2011 Mar;6(3):656-63.
5. Pashaee N et al. CYP3A5 genotype is not related to the intrapatient variability of
tacrolimus clearance. Ther Drug Monit. 2011 Jun;33(3):369-71.
Prof. Teun van Gelder 2.
School/De
partment:
Erasmus University Medical Center Rotterdam
Departments of Hospital Pharmacy and Internal Medicine
Clinical Pharmacology Unit The Netherlands
Project
Title:
Abstract:
A novel method to monitor tacrolimus concentrations after kidney transplantation within the
lymphocyte compartment.
Tacrolimus is the cornerstone immunosuppressive drug for the prevention of acute rejection after
renal transplantation. Due to its high between-patient pharmacokinetic variability, toxicity, and
narrow therapeutic window, therapeutic drug monitoring (TDM) is routinely applied. Whole
blood is currently recommended as the matrix for TDM of tacrolimus. However, the site of action
of tacrolimus is the lymphocyte compartment, which forms only a minor proportion of the cellular
components of blood. Technical limitations have so far prevented the use of more specific assays.
In view of recent progress in analytical techniques it is time to reconsider traditional methods for
TDM in organ transplantation (and beyond). In this proposal an assay based on mass spectrometry
(MS) will be developed for quantitative, intracellular measurement of tacrolimus in peripheral
blood mononuclear cells (PBMC) and lymphocyte subsets. Direct quantification of tacrolimus in
its target compartment is likely to have a closer relationship to efficacy and toxicity than whole
blood concentrations, while lacking the problems associated with pharmacodynamic assays to
monitor tacrolimus treatment. The clinical performance of this novel intracellular assay will be
determined in an observational study in which a cohort of 250 renal transplant recipients will be
followed during the first posttransplant year. During follow-up, whole blood and intracellular
tacrolimus concentrations will be measured at several time points. In addition, the
pharmacodynamic effect of tacrolimus will be determined by measuring interleukin (IL)-2
production by PBMCs. The ability of the newly-developed intracellular assay to predict acute
rejection and tacrolimus-related adverse events will be determined and compared with the
traditional whole blood concentration measurement and IL-2 production. In case the diagnostic
efficacy and clinical applicability of monitoring tacrolimus therapy by measurement of
intracellular concentrations is demonstrated, implementation of the new methodology in clinical
laboratories will lead to an important improvement in health care.
Requireme Background: The candidate is a student in pharmacy or medicine, and should have an interest in
nts
of both clinical research and analytical methods.
candidate: Master degree: pharmacy or medicine.
IELTS Grade: 7 or more (min. 6.0 per sub-score)
Supervisor Supervisor: Professor dr T. van Gelder, MD PhD, Professor in Clinical Pharmacology
informatio E-mail: t.vangelder@erasmusmc.nl
Website: http://www.erasmusmc.nl/internationalization/projects/?lang=en
n:
List of recent publications:
1. van Gelder T et al. Comparing Mycophenolate Mofetil Regimens for De Novo Renal
Transplant Recipients: The Fixed-Dose Concentration-Controlled (FDCC) Trial.
Transplantation. 2008;86:1043-51
2. van Schaik RH et al. UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low
MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients.
Clin Pharmacol Ther. 2009 Sep;86(3):319-27.
3. Borra LC et al. High within-patient variability in the clearance of tacrolimus is a risk
factor for poor long-term outcome after kidney transplantation. Nephrol Dial Transplant.
2010 Aug;25(8):2757-63.
4. de Winter BC et al. Nonlinear relationship between mycophenolate mofetil dose and
mycophenolic acid exposure: implications for therapeutic drug monitoring. Clin J Am
Soc Nephrol. 2011 Mar;6(3):656-63.
5. Pashaee N et al. CYP3A5 genotype is not related to the intrapatient variability of
tacrolimus clearance. Ther Drug Monit. 2011 Jun;33(3):369-71.
Erasmus Medical Center – Tech
Dr. Evelyn Regar
School/Depa
rtment:
Erasmus University Medical Center Rotterdam
Thorax Center
Department of Interventional Cardiology
Department of Biomedical Engineering
The Netherlands
The Dept. of Interventional Cardiology of the Thorax Center is focused on the development of
innovative percutaneous treatment strategies and the application of methods for diagnostic imaging
and therapy guidance.
In close collaboration with the Depts. of Biomedical Engineering and
Experimental Cardiology, research is performed in the fields of intravascular imaging (using optical
and ultrasonic techniques), minimally invasive therapeutic devices (such as drug-eluting-, dedicated- ,
or bioresorbable stents, aortic valve implants), acute myocardial infarction, cell therapy and
biomechanics. End goals are the introduction of novel diagnostic and therapeutic strategies in the
cardiology clinical practice for the improvement of patient care.
Project Title:
Optical coherence tomography (OCT) tissue characterization for prediction of disease progression and
guidance of percutaneous coronary interventions
Abstract:
Optical coherence tomography (OCT) is a novel, high-resolution imaging technology that has been
recently introduced into interventional cardiology. OCT has the ability to characterize the structure and
extent of coronary artery disease in unprecedented detail.
New methods for OCT image analysis are being developed in centers around the world, to extract
anatomical and compositional tissue properties. The present project aims to evaluate the clinical role of
these new technologies for prediction of disease progression and guidance of percutaneous coronary
interventions.
We will assess the role of OCT in cross sectional and in longitudinal, prospective clinical studies,
specifically designed to investigate (a) specific aspects of disease progression (e.g. lipids,
macrophages, neovascularization) as well as (b) the impact of OCT guided procedures on patients
outcome. Second/third generation OCT, tissue characterization, automated quantitative analysis
methods, including 3D rendering, will be applied.
Requirements
of candidate:
Background: Profile for Chinese PhD candidates in the Depts. Of Interventional Cardiology and
Biomedical Engineering, Thorax Center, Erasmus MC
Master degree: yes
IELTS: 7.0 (min. 6.0 per sub-score) Or TOEFL: 100 (min. 20 per sub-score)
Other: In the context of the Rotterdam-China exchange program, sponsored by EUR and CSC, we are
currently looking for two candidates who are interested to join our lab for a 4 year PhD program. The
candidates must have a solid knowledge of Medical Imaging or image processing, and should have a
background in Medicine, ideally Cardiology, or Physics, Electrical Engineering, Biomedical
Engineering, with a keen interest in Medicine. They have good command of English (written and oral)
and have recently received, or will receive in the coming months, an MSc degree in one of those fields.
We are particularly interested in meeting students with research experience in medical imaging or in
interventional cardiology.
Supervisor
Supervisor: Evelyn Regar, MD, PhD, FESC; Dept of Interventional Cardiology
information:
E-mail: e.regar@erasmusmc.nl
Co-Supervisors: Gijs van Soest, PhD; Dept of Biomedical Engineering
E-mail: g.vansoest@erasmusmc.nl
Prof. Ton van der Steen, PhD, FESC; Dept of Biomedical Engineering
E-mail: a.vandersteen@erasmusmc.nl
Thorax Center
Erasmus MC
3015 CE Rotterdam
S'-Gravendijkwal 230
The Netherlands
Relevant publication list of the supervisors:
1. van Soest, G., et al., Pitfalls in Plaque Characterization by OCT: Image Artifacts in Native Coronary
Arteries. J Am Coll Cardiol Img, 2011. 4(7): p. 810-813.
2. Regar, E., et al., The diagnostic value of intracoronary optical coherence tomography. Herz, 2011.
36(5): p. 417-429.
3. Jansen, K., et al., Intravascular photoacoustic imaging of human coronary atherosclerosis. Opt.
Lett., 2011. 36(5): p. 597-599.
4. Gutiérrez-Chico, J.L., et al., Delayed Coverage in Malapposed and Side-Branch Struts With Respect
to Well-Apposed Struts in Drug-Eluting Stents / Clinical Perspective. Circulation, 2011. 124(5): p.
612-623.
5. Gonzalo, N., et al., Witnessed Coronary Plaque Rupture During Cardiac Catheterization. J Am Coll
Cardiol Img, 2011. 4(4): p. 437-438.
6. Gonzalo, N., et al., Relation between plaque type and dissections at the edges after stent
implantation: An optical coherence tomography study. Int J Cardiol, 2011. 150(2): p. 151-155.
7. van Soest, G., et al., Atherosclerotic tissue characterization in vivo by optical coherence tomography
attenuation imaging. J Biomed Opt, 2010. 15(1): p. 011105-9.
8. Serruys, P.W., et al., Evaluation of the Second Generation of a Bioresorbable Everolimus
Drug-Eluting Vascular Scaffold for Treatment of De Novo Coronary Artery Stenosis: Six-Month
Clinical and Imaging Outcomes. Circulation, 2010. 122(22): p. 2301-2312.
9. Schultz, C.J., et al., First-in-man clinical use of combined near-infrared spectroscopy and
intravascular ultrasound: a potential key to predict distal embolization and no-reflow? J Am Coll
Cardiol, 2010. 56(4): p. 314.
10. Regar, E., et al., Optical coherence tomography in patients with acute coronary syndrome.
EuroIntervention, 2010. 6 Suppl G: p. G154-60.
11. Onuma, Y., et al., Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2,
3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a
Porcine Coronary Artery Model: An Attempt to Decipher the Human Optical Coherence
Tomography Images in the ABSORB Trial. Circulation, 2010. 122(22): p. 2288-2300.
12. Okamura, T., et al., Reproducibility of coronary Fourier domain optical coherence tomography:
quantitative analysis of in vivo stented coronary arteries using three different software packages.
EuroIntervention, 2010. 6(3): p. 371-379.
13. Gonzalo, N., et al., Second-generation optical coherence tomography in clinical practice.
High-speed data acquisition is highly reproducible in patients undergoing percutaneous coronary
intervention. Revista Espanola De Cardiologia, 2010. 63(8): p. 893-903.
14. Goderie, T.P.M., et al., Combined optical coherence tomography and intravascular ultrasound
radio frequency data analysis for plaque characterization. Classification accuracy of human
coronary plaques in vitro. International Journal Of Cardiovascular Imaging, 2010. 26(8): p.
843-850.
15. Serruys, P.W., et al., A bioabsorbable everolimus-eluting coronary stent system (ABSORB): 2-year
outcomes and results from multiple imaging methods. Lancet, 2009. 373(9667): p. 897-910.
16. Prati, F., et al., Expert review document on methodology, terminology, and clinical applications of
optical coherence tomography: physical principles, methodology of image acquisition, and clinical
application for assessment of coronary arteries and atherosclerosis. Eur Heart J, 2009.
17. Gonzalo, N., et al., Optical coherence tomography patterns of stent restenosis. Am Heart J, 2009.
158(2): p. 284-93.
18. Gonzalo, N., et al., Optical coherence tomography assessment of the acute effects of stent
implantation on the vessel wall: a systematic quantitative approach. Heart, 2009. 95(23): p.
1913-9.
19. Gonzalo, N., et al., Quantitative Ex Vivo and In Vivo Comparison of Lumen Dimensions Measured
by Optical Coherence Tomography and Intravascular Ultrasound in Human Coronary Arteries.
Rev Esp Cardiol, 2009. 62(6): p. 615-624.
20. Gonzalo, N., et al., In Vivo Assessment of High-Risk Coronary Plaques at Bifurcations With
Combined Intravascular Ultrasound and Optical Coherence Tomography. J Am Coll Cardiol Img,
2009. 2(4): p. 473-482.
21. Barlis, P., et al., Intracoronary optical coherence tomography and the evaluation of stents. Expert
Rev Med Devices, 2009. 6(2): p. 157-67.
22. Tanimoto, S., et al., A novel approach for quantitative analysis of intracoronary optical coherence
tomography: High inter-observer agreement with computer-assisted contour detection. Catheter
Cardiovasc Interv, 2008. 72(2): p. 228-235.
23. Ormiston, J.A., et al., A bioabsorbable everolimus-eluting coronary stent system for patients with
single de-novo coronary artery lesions (ABSORB): a prospective open-label trial. Lancet, 2008.
371(9616): p. 899-907.
24. Barlis, P., et al., Assessment of culprit and remote coronary narrowings using optical coherence
tomography with long-term outcomes. Am J Cardiol, 2008. 102(4): p. 391-395.
25. Barlis, P., et al., Optical coherence tomography assessment of vulnerable plaque rupture:
predilection for the plaque 'shoulder'. Eur Heart J, 2008.
26. van Soest, G., et al., Robust intravascular optical coherence elastography by line correlations.
Phys Med Biol, 2007. 52(9): p. 2445-58.
27. Regar, E., T.G. van Leeuwen, and P.W. Serruys, eds. Optical Coherence Tomography in
Cardiovascular Research. 2007, Informa Healthcare: Oxon UK.
28. Regar, E., et al., Optical Coherence Tomography Findings at 5-Year Follow-Up After Coronary
Stent Implantation. Circulation, 2005. 112(23): p. e345-346.
Dr. Fan Liu
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Forensic Molecular Biology The Netherlands
Project Title:
PhD in computational genetics on the genetic and prediction of human appearance
Abstract:
The PhD position is focused on genetic epidemiology and statistical genetics. The topic of the
project is on genome-wide association and prediction of human externally visible traits
(appearance). Specific emphasis will be placed on the development of novel analytical approaches
to the analysis of hypotheses related to genetic interactions. The main research objectives include,
(1) identification of genetic variants that are associated with human externally visible traits using
genome-wide SNP and next generation sequencing data, and (2) prediction of human externally
visible traits based on DNA variants. The project is highly related to various disciplines of
knowledge such as genetics, genetic epidemiology, statistics, and bioinformatics and may have
future relevance for forensic sciences. The successful candidate is expected to obtain a PhD in
computational genetics in 4 years.
Responsibilities:
Successfully take required lectures and pass exams (20%).
Conduct scientific studies and produce papers (60%).
Participate in group sessions such as journal clubs, working progress meetings, and collaborate
with colleagues on other projects (20%).
Musts:
Fluent in English.
Chinese and currently living in China.
Having a MSc or higher degree in bioinformatics, computer science, statistics, epidemiology or
related fields.
Solid background in either computer programming or statistics.
Pluses:
Previous publications on international peer reviewed journals.
Experience in analysis of extremely large data sets.
Experience in Linux operation system.
Requireme
nts
of
candidate:
Supervisor
informatio
n:
Background: Bioinformatics, Computer Science, Statistics, Epidemiology or related fields
Master degree: Yes
IELTS: 7.0 (min. 6.0 per sub-score) Or TOEFL: 100 (min. 20 per sub-score)
Supervisor: Prof. Dr. Manfred Kayser E-mail: m.kayser@erasmusmc.nl
Co-Supervisor: Dr. Fan Liu E-mail: f.liu@erasmusmc.nl
Department of Forensic Molecular Biology
Erasmus University Medical Center Rotterdam
P.O. Box 2040, 3000 CA Rotterdam
The Netherlands,
Phone: ++31-10-7038073 Fax: ++31-10-7044575
Publication lists:
1. Kayser M, Liu F, Janssens AC, Rivadeneira F, Lao O, et al. (2008) Three genome-wide
association studies and a linkage analysis identify HERC2 as a human iris color gene.
Am J Hum Genet 82: 411-423.
2. Estrada K, Krawczak M, Schreiber S, van Duijn K, Stolk L, et al. (2009) A genome-wide
association study of northwestern Europeans involves the C-type natriuretic peptide
signaling pathway in the etiology of human height variation. Hum Mol Genet 18:
3516-3524.
3. Liu F, van Duijn K, Vingerling JR, Hofman A, Uitterlinden AG, et al. (2009) Eye color
and the prediction of complex phenotypes from genotypes. Curr Biol 19: R192-193.
4. Liu F, Wollstein A, Hysi PG, Ankra-Badu GA, Spector TD, et al. (2010) Digital
quantification of human eye color highlights genetic association of three new loci. PLoS
Genet 6: e1000934.
5. Branicki W, Liu F, van Duijn K, Draus-Barini J, Pospiech E, et al. (2011) Model-based
prediction of human hair color using DNA variants. Hum Genet.
6. Kayser M, de Knijff P (2011) Improving human forensics through advances in genetics,
genomics and molecular biology. Nat Rev Genet 12: 179-192.
Dr. Frank Gijsen
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Biomedical Engineering and Experimental Cardiology
The Netherlands
Project Title:
Assessment of carotid plaque vulnerability with MR strain mapping
Abstract:
Atherosclerosis is a vascular condition in which an artery wall thickens as a result
of a build-up of fatty tissue, such as cholesterol. In an advanced stage, unstable
plaques containing lipid pools and calcifications are present in the arterial wall,
with a thin fibrous cap separating the lipid pool from the blood flow. Rupture of
this cap instigates thrombosis formation, which is the major cause for stroke.
Detection of unstable plaques is essential for improvement of patient treatment
strategy.
Invasive ultrasound measurements in coronary arteries have shown that strain in
the plaque can be used to identify unstable plaques. We want to apply this method
in carotid arteries of patients to separate stable from unstable plaque in a
non-invasive manner. High resolution MR imaging will be performed in patients
elected for carotid endarterectomy. After optimizing the imaging procedure, we
will use dedicated in-house developed software to determine the strain maps. The
measured strain maps based on the in-vivo MR imaging procedure will be
compared to histological plaque features to investigate whether strain imaging in
carotid arteries can be used to indentify unstable plaque in a non-invasive manner.
Requireme Background: The candidate must have a background in biomedical engineering or imaging
nts
of with a keen interest in MR imaging and image processing. The research project should result
candidate: in a PhD thesis.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) OR
TOEFL: 100 (min. 20 per sub-score)
Supervisor Supervisors: Dr. Frank Gijsen and Dr. Lambert Speelman
informatio E-mail: f.gijsen@erasmusmc.nl, l.speelman@erasmusmc.nl
Prof.Dr.Ir. Ton van der Steen, PhD, FESC, Professor;
n:
E-mail: a.vandersteen@erasmusmc.nl
http://www.erasmusmc.nl/thoraxcenterbme/Current-Research/BML/
Biomedical Engineering is part of the Thoraxcenter of the Erasmus Medical Center in
Rotterdam, The Netherlands. The research group led by prof.dr.ir. A. F. W. van der Steen,
and is located at the Medical Faculty of the Erasmus University. The group focuses on the
origin, diagnosis and treatment of cardiovascular diseases by bringing together two technical
specialties of the Thoraxcenter, being experimental echocardiography and bioimechanics.
List of recent publications:
Gijsen, F.J.H., et al., A new imaging technique to study 3-D plaque and shear stress distribution in
human coronary artery bifurcations in vivo. Journal of Biomechanics, 2007. 40(11): p.
2349-2357.
Groen, H.C., et al., Plaque rupture in the carotid artery is localized at the high shear stress
region: A case report. Stroke, 2007. 38(8): p. 2379-2381.
Cheng, C., et al., Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovascular
Research, 2008. 78(1): p. 123-129.
Gijsen, F.J.H., et al., Simulation of stent deployment in a realistic human coronary artery.
BioMedical Engineering Online, 2008. 7.
Gijsen, F.J.H., et al., Strain distribution over plaques in human coronary arteries relates to shear
stress. American Journal of Physiology - Heart and Circulatory Physiology, 2008. 295(4): p.
H1608-H1614.
Schuurbiers, J.C.H., et al., In vivo validation of CAAS QCA-3D coronary reconstruction using
fusion
of
angiography
and
intravascular
ultrasound
(ANGUS).
Catheterization
and
Cardiovascular Interventions, 2009. 73(5): p. 620-626.
van der Giessen, A.G., et al., Plaque and shear stress distribution in human coronary bifurcations:
a multislice computed tomography study. EuroIntervention : journal of EuroPCR in collaboration
with the Working Group on Interventional Cardiology of the European Society of Cardiology,
2009. 4(5): p. 654-661.
Groen, H.C., et al., MRI-based quantification of outflow boundary conditions for computational
fluid dynamics of stenosed human carotid arteries. Journal of Biomechanics, 2010. 43(12): p.
2332-2338.
Groen, H.C., et al., Three-dimensional registration of histology of human atherosclerotic carotid
plaques to in-vivo imaging. Journal of Biomechanics, 2010. 43(11): p. 2087-2092.
van der Giessen, A.G., et al., Reproducibility, accuracy, and predictors of accuracy for the
detection of coronary atherosclerotic plaque composition by computed tomography: An ex vivo
comparison to intravascular ultrasound. Investigative Radiology, 2010. 45(11): p. 693-701.
Gijsen, F.J.H., et al., High shear stress induces a strain increase in human coronary plaques over
a 6-month period. Accepted for publication in EuroIntervention, 2010.
Akyildiz, A.C., et al., Effects of intima stiffness and plaque morphology on peak cap stress.
BioMedical Engineering Online, 2011. 10.
Speelman, L., et al., Initial stress in biomechanical models of atherosclerotic plaques. J Biomech.
44(13): p. 2376-82, 2011.
Papadopoulou, S.L., et al., Detection and quantification of coronary atherosclerotic plaque by
64-slice multidetector CT: A systematic head-to-head comparison with intravascular ultrasound.
Atherosclerosis, 2011.
van der Giessen, A.G., et al., The influence of boundary conditions on wall shear stress
distribution in patients specific coronary trees. J Biomech. 44(6): p. 1089-95, 2011.
Dr. Heleen van Beusekom.
School/De
partment:
Erasmus University Medical Center Rotterdam Thorax Center
Department of Experimental Cardiology
Department of Biomedical Engineering The Netherlands
Project
Title:
Abstract:
Imaging the pathophysiological response to coronary interventions; an experimental and
computational approach
Atherosclerosis is a major health care burden, responsible for nearly 40% mortality in the western
world. Atherosclerotic coronary artery disease, often complicated by (athero)thrombosis leading to
acute myocardial infarction constitutes a dominant part of this problem. Percutaneous Coronary
Intervention (PCI) by implantation of a drug eluting stent (DES) is currently the treatment of choice
for acute coronary syndromes as well as stable angina.
In this project we will study the relation between the vascular environment (structures such as
atheromatous plaque, fibrous intimal thickening, coronary thrombus), local and distal vascular drug
uptake, vascular healing and microvascular function following DES placement. To this end, we will
apply a combination of in vivo imaging in an animal model for coronary atherosclerosis, ex vivo
molecular histology by means of imaging mass spectrometry (IMS), and numerical modeling of drug
transport in the vascular bed.
Until now limited information is available on the concentration distribution of drugs and drug vehicles
along the vessel lumen and inside the atherosclerotic vessel wall. Convection and diffusion of
molecules into the blood and wall largely depends on their size, charge, and whether the compound is
lipophilic or hydrophilic. We will image the pathophysiological response of the coronary circulation to
the intervention by means of several intravascular imaging techniques, and match that diagnostic
information to the molecular histology, studying pharmacokinetics, drug metabolites, and plaque
lipidomics. A numerical model will be developed and validated based on these data, to compute the
distribution of compounds with different molecular sizes at the lumen and in the vessel wall using
realistic 3D reconstructions of lumen and wall of coronary arteries. At the end of this project, we will
have created a tool to predict the vascular response to DES placement in patients, based on diagnostic
imaging and patient-specific modeling.
Requirem
ents
of
candidate:
Background: A solid knowledge of biochemistry or mass spectrometry, and should have a background
in Chemistry, Biology, or Physics, with a keen interest in Medicine, particularly cardiology.
Master degree: yes
IELTS Grade: 7.0 (min. 6.0 per sub-score)
Or
TOEFL: 100 (min. 20 per sub-score)
Other: In the context of the Rotterdam-China exchange program, sponsored by EUR and CSC, we are
currently looking for two candidates who are interested to join our lab for a 4 year PhD program.
Candidate 1 must have a solid knowledge of biochemistry or mass spectrometry, and should have a
background in Chemistry, Biology, or Physics; candidate 2 must have a solid knowledge of Biomedical
Engineering, with affinity for finite element modeling and/or experimental studies.
Both should have a keen interest in Medicine, particularly cardiology, good command of English
(written and oral) and have recently received, or will receive in the coming months, an MSc degree in
a suitable field.
Supervisor
informatio
n:
Supervisor: Heleen van Beusekom, PhD
Senior Scientist; h.vanbeusekom@erasmusmc.nl
Department of Experimental Cardiology
Co- Supervisors: Gijs van Soest, PhD, Assistant Professor;
E-mail: g.vansoest@erasmusmc.nl
J.J. Wentzel , PhD Associate Professor;
E-mail j.wentzel@erasmusmc.nl
Ton van der Steen, PhD, FESC, Professor;
E-mail: a.vandersteen@erasmusmc.nl
Department of Biomedical Engineering
Thorax Center
Erasmus MC
PO Box 2040
3000 CA Rotterdam
The Netherlands
Relevant publication list; all supervisors:
9. Wentzel JJ, et al., Stent implantation in coronary arteries causes alterations in 3-D geometry and
distribution of 3-D shear stress at the endothelium. Journal of Biomechanics, 2000,
33:10:1287-1295.
10. Slager CJ, et al. True 3-D Reconstruction of Coronary Arteries in Patients by fusion of
Angiography and IVUS (ANGUS) and its Quantitative Validation. Circulation, 2000, 102:
511-516.
11. Wentzel JJ,
et al. The relationship between neointimal thickness and shear stress after Wallstent
implantation in human coronary arteries at 6 months follow up. Circulation, 2000, 102: 1740-1745.
12. Thury A,
et al. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress?
Circulation, 2002, Jun 11;105(23):e185-7.
13. Wentzel JJ, et al. Shear stress, vascular remodeling and neointimal formation. J Biomech., 2003,
May;36(5):681-8.
14. Gijsen FJH, et al. Tissue regression in sirolimus-eluting stents in human coronary arteries is
localized and correlates with shear stress. Am J Cardiol., 2003, Dec 1;92(11):1325-8.
15. ten Have AG, et al. Temperature distribution in atherosclerotic coronary arteries: influence of
plaque geometry and flow (a numerical study). Phys Med Biol., 2004, Oct 7;49(19):4447-62.
16. Slager CJ, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat
Clin Pract Cardiovasc Med., 2005, Aug;2(8):401-7.
10. Slager CJ, et al. The role of shear stress in destabilization of vulnerable plaques and related
therapeutic implications. Nat Clin Pract Cardiovasc., 2005, Sept;2(9):456-64.
24. ten Have A, et al. Intracoronary thermography: Heat generation, transfer and detection,
EuroIntervention 1(1); May 2005: 105-114
25. Ten Have AG, et al. Influence of catheter design on lumen wall temperature distribution in
intracoronary thermography. J Biomech. 2007;40(2):281-8.
26. Ten Have AG, et al. A numerical study on the influence of vulnerable plaque composition on
intravascular thermography measurements. Phys Med Biol. 2006 Nov 21;51(22):5875-87.
27. Wentzel JJ,
et al. In vivo 3D distribution of lipid-core plaque in human coronary artery as
assessed by fusion of near infrared spectroscopy-intravascular ultrasound and multislice computed
tomography scan.Circ Cardiovasc Imaging. 2010 Nov 1;3(6):e6-7.
28. Commandeur S, et al. Polymers, drug release, and drug-eluting stents. J Interv Cardiol. 2006
Dec;19(6):500-6. Review
29. van Beusekom HM, et al.
Drug-eluting stents show delayed healing: paclitaxel more pronounced
than sirolimus. Eur Heart J. 2007 Apr;28(8):974-9.
30. van Beusekom et al. The neointimal response to stents eluting tacrolimus from a degradable
coating depends on the balance between polymer degradation and drug release.
EuroIntervention.
2008 May;4(1):139-47.
31. Onuma Y, et al The paradigm of endothelium and stent thrombosis in DES. EuroIntervention. 2008
Aug;4 Suppl C:C17-21.
32. Ertaş G, van Beusekom HM, van der Giessen WJ. Late stent thrombosis, endothelialisation and
drug-eluting stents. Neth Heart J. 2009 Apr;17(4):177-80.
33. van den Heuvel M, et al. Endothelial dysfunction after drug eluting stent implantation. Minerva
Cardioangiol. 2009 Oct;57(5):629-43. Review.
34. van Beusekom HM, et al. Endothelial function rather than endothelial restoration is altered in
paclitaxel- as compared to bare metal-, sirolimusand tacrolimus-eluting stents. EuroIntervention.
2010 May;6(1):117-25. doi: 10.4244/.
35. van den Heuvel M, et al.
Specific coronary drug-eluting stents interfere with distal microvascular
function after single stent implantation in pigs. JACC Cardiovasc Interv. 2010 Jul;3(7):723-30.
Erratum in: JACC Cardiovasc Interv. 2010 Sep;3(9):994.
36. Van Der Giessen WJ, Van Beusekom HM. New drug-eluting stents with biodegradable polymers.
Minerva Cardioangiol. 2011 Feb;59(1):31-8.
24. Gonzalo N, et al. Optical coherence tomography patterns of stent restenosis. Am Heart J.
2009;158(2):284-293.
25. van Soest G, et al. Atherosclerotic tissue characterization in vivo by optical coherence tomography
attenuation imaging. J Biomed Opt. 2010;15(1):011105-011109.
26. Goderie TPM, et al. Combined optical coherence tomography and intravascular ultrasound radio
frequency data analysis for plaque characterization. Classification accuracy of human coronary
plaques in vitro. International Journal Of Cardiovascular Imaging. 2010;26(8):843-850.
27. Garg S, et al. First use in patients of a combined near infra-red spectroscopy and intra-vascular
ultrasound catheter to identify composition and structure of coronary plaque. EuroIntervention.
2010;5(6):755-756.
28. Regar E, et al. Optical coherence tomography in patients with acute coronary syndrome.
EuroIntervention. 2010;6 Suppl G:G154-160.
29. Gonzalo N, et al. Witnessed Coronary Plaque Rupture During Cardiac Catheterization. JACC
Cardiovasc Imaging. 2011;4(4):437-438.
30. Regar E, et al. The diagnostic value of intracoronary optical coherence tomography. Herz.
2011;36(5):417-429.
31. van Soest G, et al. Pitfalls in Plaque Characterization by OCT: Image Artifacts in Native Coronary
Arteries. J Am Coll Cardiol Img. 2011;4(7):810-813.
32. Jansen K, et al. Intravascular photoacoustic imaging of human coronary atherosclerosis. Opt. Lett.
2011;36(5):597-599.
Dr. Marleen de Bruijne 1
School/De
partment:
Erasmus University Medical Center Rotterdam
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl
The Netherlands
Project Title:
MR brain image analysis
Abstract:
MR images of the brain reveal evidence of neurological disorders already before clinical
symptoms appear. For instance, some brain structures are slightly smaller in people who will
develop dementia later on. Such image based markers are of enormous importance for early
diagnosis and may lead to improved treatment in an early stage. Erasmus MC performs a large
scale image based study of the aging brain to investigate the complex neurodegenerative patterns
involved in the development of dementia as well as in normal aging. Within this study,
multi-sequence MR brain data of approximately 5500 participants is collected at intervals of three
years. In addition, a large set of multimodal brain scans of young children is currently collected to
study factors determining brain development. In this PhD project you will develop model based
segmentation techniques to automatically analyze brain structures and lesions in these databases,
and you will use machine learning techniques to derive image markers, related to the shape, size,
and appearance of brain structures, that can help in recognizing different disorders such as
Alzheimer's disease. We suggest the following topics to work on within this PhD project, but you
are welcome to define related topics yourself in your proposal.
5. Automatic detection of microbleeds
• Microbleeds are small bleedings in the brain which are associated with a higher risk on
brain disorders and which are visible as dark spots on some MR sequences (Fig 1). A dataset
of several hundreds of MR scans with manually annotated microbleeds is available to
develop, train, and evaluate a computer aided detection system. The successful microbleed
detection system will be applied in epidemiological studies as well as in the dementia clinic.
6. Segmentation of brain structures
• Several studies measuring e.g. the volume of different brain structures have relied on
manual segmentations (Fig 2), but large scale studies require automated analysis. We have
previously developed a technique for automatic segmentation of one of the brain structures,
the hippocampus (Fig 3). This technique should be extended to cope with multiple different
structures.
7. Shape analysis of brain structures
• We have already developed and evaluated methods for hippocampus shape analysis (Fig 4),
which were shown to detect dementia in an earlier stage than does hippocampal volume.
Techniques to simultaneously analyze a number of structures need to be developed.
8. Changes over time
• We will use image registration to accurately measure changes as a result of disease
progression, aging, or growth, based on scans taken from the same person at different points
in time. Techniques used in this project: Image segmentation, pattern recognition, image
registration.
(all Figures are not available in this document)
Requireme Background: You should have a Master's degree in Physics, Electrical Engineering, Mathematics,
nts
of Biomedical Engineering, Computer Science, or a related field. Experience with biomedical image
candidate: analysis and/or machine learning is an advantage. You should be familiar with programming. You
should be able to work in a multi-disciplinary team. Strong theoretical skills and affinity with
experimental work are required.
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Dr. Marleen de Bruijne E-mail: marleen.debruijne@erasmusmc.nl
informatio Marleen de Bruijne is an associate professor in medical image analysis both at the Erasmus MC,
Rotterdam, The Netherlands and at the Department of Computer Science, University of
n:
Copenhagen, Denmark. She leads the "Model-based Medical Image Analysis" research group in
which she develops novel techniques for quantitative analysis of medical images, with a focus on
large scale image-based studies. Her research interests include shape analysis, model based
segmentation, and pattern recognition approaches in a variety of applications. Dr. de Bruijne
(co)authored 85 peer-reviewed full papers in international conference proceedings and journals
and 17 patent applications (2 granted) and co-edited 4 books. She currently supervises 6 PhD
students 2 postdocs and has (co)supervised 6 PhD students who graduated in the last 5 years. She
is a member of the Program Committee of over 25 international conferences including the two
primary conferences in the field - SPIE Medical Imaging and MICCAI. She is also an editorial
board member of Medical Image Analysis.
An extended CV and publication list are available from http://image.diku.dk/marleen/
Dr. Marleen de Bruijne 2
School/De
partment:
Erasmus University Medical Center Rotterdam
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl The Netherlands
Project Title:
Computer aided diagnosis of lung diseases from CT imaging
Abstract:
Accurate and reproducible quantification of abnormalities in lung images is crucial to
improve our understanding of the factors involved in development and progression of
lung diseases, to assess the effect of treatment, and to recognize problems as early as
possible and determine prognosis in individual patients. For this, automated image
analysis is required, which is especially challenging in lung images because of the
large deformations that occur during breathing.
Pulmonary image analysis at BIGR focuses on measuring structural lung damage in
patients with cystic fibrosis (CF) - both in very early and in advanced stages - and on
quantifying chronic obstructive pulmonary disease (smoker's lung, COPD) from CT
images.
We suggest the following topics to work on within this PhD project, but you may also
define related topics yourself.
1. Analysis of the airways
• Untreated lung disease can lead to irreversible damage to the airways, which can be
seen e.g. as a widening of the airway lumen or thickening of the wall. To detect this
in an early stage, segmentation of the airways and of the neighboring vessels is
needed. Some approaches exist, but these are not able to segment the smaller airways
and should therefore be improved (Fig 1).
2. Segmenting areas with trapped air
• Air trapping, where parts of the air in the lung cannot be exhaled properly, is a sign
of airway obstruction (Fig 2). We would like to measure the size and shapes of
regions of trapped air, and investigate how they change over time.
3. Texture classification
• Different lung abnormalities show a distinctive texture in the image (Fig3).
Classifying the different textures can be used to detect and quantify lung disease.
4. Changes over time
• To detect the onset or progression of lung disease, we should be able to measure any
changes in e.g. airways, trapped air, and lung texture. Robust image registration
methods need to be developed.
5. CT versus MRI
• Currently, CT is the most sensitive method to detect lung abnormalities. However,
because of the radiation applied in CT imaging MRI is sometimes preferred,
especially in dynamic imaging, in young children, or if a patient should be imaged
frequently. At Erasmus MC we therefore investigate lung MRI as a safe alternative to
lung CT. We followed a group of patients with both CT and MRI, which provides a
perfect database to develop algorithms for analysis of lung MRI and to investigate the
value of MRI compared to CT.
Techniques used in this project: Image segmentation, pattern recognition, image
registration. (all Figures are not available in this document)
Requireme Background: You should have a Master's degree in physics, electrical engineering, mathematics,
nts
of biomedical engineering, computer science, or a related field. Experience with biomedical image
candidate: analysis and/or machine learning is an advantage. You should be familiar with programming. You
should be able to work in a multi-disciplinary team. Strong theoretical skills and affinity with
experimental work are required.
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score)
or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Supervisor: Dr. Marleen de Bruijne E-mail: marleen.debruijne@erasmusmc.nl
informatio Marleen de Bruijne is an associate professor in medical image analysis both at the Erasmus MC,
Rotterdam, The Netherlands and at the Department of Computer Science, University of
n:
Copenhagen, Denmark. She leads the "Model-based Medical Image Analysis" research group in
which she develops novel techniques for quantitative analysis of medical images, with a focus on
large scale image-based studies. Her research interests include shape analysis, model based
segmentation, and pattern recognition approaches in a variety of applications.
Dr. de Bruijne (co)authored 85 peer-reviewed full papers in international conference proceedings
and journals and 17 patent applications (2 granted) and co-edited 4 books. She currently
supervises 6 PhD students 2 postdocs and has (co)supervised 6 PhD students who graduated in the
last 5 years. She is a member of the Program Committee of over 25 international conferences
including the two primary conferences in the field - SPIE Medical Imaging and MICCAI. She is
also an editorial board member of Medical Image Analysis.
An extended CV and publication list are available from http://image.diku.dk/marleen/
Dr. Mischa Hoogeman
School/
Department:
Erasmus University Medical Center - Daniel den Hoed Cancer Center
Department of Radiation Oncology
School Molecular Medicine (www.molmed.nl) The Netherlands
Project Title:
Computer Aided Plan Selection for Online Adaptive Radiotherapy
Abstract:
Online Adaptive Radiotherapy (OART) is an advanced type of image-guided radiotherapy.
It uses three and four-dimensional imaging data of the tumor and surrounding tissue,
which is acquired just prior to the delivery of the radiation, to select the best fitting
treatment plan from a library of plans. The complexity of the patient anatomy and the
complexity of the treatment plans require computer assistance in the selection procedure.
One of the research lines of our department is the development of Computer Aided Plan
Selection (CAPS) strategies. CAPS breaks down into two components, i.e. fast and robust
segmentation of the relevant patient anatomy and accurate plan selection based on often
sparse information. This research will focus on the development of segmentation
techniques for CAPS for cervical and prostate cancer, and for tumors in the liver. The
segmentation techniques will be primarily knowledge-based, i.e. atlas-based and/or using
active shape and appearance models. The techniques will be applied and evaluated on
Computer Tomography (CT) and Cone Beam CT image data of clinical patients.
Algorithm development will take place in our in-house developed software platform for
image and geometry processing.
Requirements
candidate:
Supervisor
information:
of
Background: Creative researcher with experience in software development (Matlab,
Python, C++), preferably in the field of medical image or geometry processing.
Master degree: Yes, Computer Science, Physics, or Applied Mathematics
IELTS Grade: at least 7.0 on average (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Supervisor: Assoc. Prof. dr. Mischa S. Hoogeman (Medical Physicist, PhD)
E-mail: m.hoogeman@erasmusmc.nl
Erasmus MC - Daniel den Hoed Cancer Center
Department of Radiation Oncology
Groene Hilledijk 301
3075 EA Rotterdam
The Netherlands
Tel: +31 10 704 17 48, Fax: +31 10 704 10 12
Prof. dr. Ben J.M. Heijmen (Medical Physcist, PhD), Work Group Leader
E-mail: b.heijmen@erasmusmc.nl
Website: http://www.erasmusmc.nl/radiotherapie/research/radiationoncologyandphysics/
Recent publication list:
30.
Voet PW, Dirkx ML, Teguh DN, Hoogeman MS, Levendag PC, Heijmen BJ. Does atlas-based
autosegmentation of neck levels require subsequent manual contour editing to avoid risk of severe
target underdosage? A dosimetric analysis. Radiother Oncol. 2011 Mar;98(3):373-7.
31.
Vasquez Osorio EM, Hoogeman MS, Teguh DN, Al-Mamgani A, Kolkman-Deurloo IK, Bondar L, et
al. Three-dimensional dose addition of external beam radiotherapy and brachytherapy for
oropharyngeal patients using nonrigid registration. Int J Radiat Oncol Biol Phys. 2011 Jul
15;80(4):1268-77.
32.
van der Voort van Zyp NC, Hoogeman MS, van de Water S, Levendag PC, van der Holt B, Heijmen
BJ, et al. Stability of Markers Used for Real-Time Tumor Tracking After Percutaneous
Intrapulmonary Placement. Int J Radiat Oncol Biol Phys. 2011 Feb 22.
33.
van de Water S, Hoogeman MS, Breedveld S, Nuyttens JJ, Schaart DR, Heijmen BJ. Variable Circular
Collimator in Robotic Radiosurgery: A Time-Efficient Alternative to a Mini-Multileaf Collimator? Int
J Radiat Oncol Biol Phys. 2011 Mar 4.
34.
van de Water S, Hoogeman MS, Breedveld S, Heijmen BJ. Shortening treatment time in robotic
radiosurgery using a novel node reduction technique. Med Phys. 2011 Mar;38(3):1397-405.
35.
Depuydt T, Verellen D, Haas O, Gevaert T, Linthout N, Duchateau M, et al. Geometric accuracy of a
novel gimbals based radiation therapy tumor tracking system. Radiother Oncol. 2011
Mar;98(3):365-72.
36.
Budiarto E, Keijzer M, Storchi PR, Hoogeman MS, Bondar L, Mutanga TF, et al. A population-based
model to describe geometrical uncertainties in radiotherapy: applied to prostate cases. Phys Med Biol.
2011 Feb 21;56(4):1045-61.
37.
Bondar L, Hoogeman M, Mens JW, Dhawtal G, de Pree I, Ahmad R, et al. Toward an individualized
target motion management for IMRT of cervical cancer based on model-predicted cervix-uterus shape
and position. Radiother Oncol. 2011 May;99(2):240-5.
38.
Ahmad R, Hoogeman MS, Bondar M, Dhawtal V, Quint S, De Pree I, et al. Increasing treatment
accuracy for cervical cancer patients using correlations between bladder-filling change and
cervix-uterus displacements: proof of principle. Radiother Oncol. 2011 Mar;98(3):340-6.
39.
van der Voort van Zyp NC, Hoogeman MS, van de Water S, Levendag PC, van der Holt B, Heijmen
BJ, et al. Clinical introduction of Monte Carlo treatment planning: a different prescription dose for
non-small cell lung cancer according to tumor location and size. Radiother Oncol. 2010
Jul;96(1):55-60.
40.
Teguh DN, Levendag PC, Voet PW, Al-Mamgani A, Han X, Wolf TK, et al. Clinical Validation of
Atlas-Based Auto-Segmentation of Multiple Target Volumes and Normal Tissue
(Swallowing/Mastication) Structures in the Head and Neck. Int J Radiat Oncol Biol Phys. 2010 Oct 5.
41.
Mutanga TF, de Boer HC, van der Wielen GJ, Hoogeman MS, Incrocci L, Heijmen BJ. Margin
Evaluation in the Presence of Deformation, Rotation, and Translation in Prostate and Entire Seminal
Vesicle Irradiation with Daily Marker-Based Setup Corrections. Int J Radiat Oncol Biol Phys. 2010
Oct 29.
42.
Bondar L, Hoogeman MS, Vasquez Osorio EM, Heijmen BJ. A symmetric nonrigid registration
method to handle large organ deformations in cervical cancer patients. Med Phys. 2010
Jul;37(7):3760-72.
43.
Aluwini S, van Rooij P, Hoogeman M, Bangma C, Kirkels WJ, Incrocci L, et al. CyberKnife
stereotactic radiotherapy as monotherapy for low- to intermediate-stage prostate cancer: early
experience, feasibility, and tolerance. J Endourol. 2010 May;24(5):865-9.
44.
Vasquez Osorio EM, Hoogeman MS, Bondar L, Levendag PC, Heijmen BJ. A novel flexible
framework with automatic feature correspondence optimization for nonrigid registration in
radiotherapy. Med Phys. 2009 Jul;36(7):2848-59.
45.
van der Voort van Zyp NC, Prevost JB, Hoogeman MS, Praag J, van der Holt B, Levendag PC, et al.
Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical
outcome. Radiother Oncol. 2009 Jun;91(3):296-300.
46.
Hoogeman M, Prevost JB, Nuyttens J, Poll J, Levendag P, Heijmen B. Clinical accuracy of the
respiratory tumor tracking system of the cyberknife: assessment by analysis of log files. Int J Radiat
Oncol Biol Phys. 2009 May 1;74(1):297-303.
47.
Vasquez Osorio EM, Hoogeman MS, Al-Mamgani A, Teguh DN, Levendag PC, Heijmen BJ. Local
anatomic changes in parotid and submandibular glands during radiotherapy for oropharynx cancer
and correlation with dose, studied in detail with nonrigid registration. Int J Radiat Oncol Biol Phys.
2008 Mar 1;70(3):875-82.
48.
van der Wielen GJ, Mutanga TF, Incrocci L, Kirkels WJ, Vasquez Osorio EM, Hoogeman MS, et al.
Deformation of prostate and seminal vesicles relative to intraprostatic fiducial markers. Int J Radiat
Oncol Biol Phys. 2008 Dec 1;72(5):1604-11 e3.
49.
van der Wielen GJ, Hoogeman MS, Dohle GR, van Putten WL, Incrocci L. Dose-volume parameters
of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy
for prostate cancer: results from a dose-escalation trial. Int J Radiat Oncol Biol Phys. 2008 Jul
1;71(3):795-800.
50.
Prevost JB, Voet P, Hoogeman M, Praag J, Levendag P, Nuyttens JJ. Four-dimensional stereotactic
radiotherapy for early stage non-small cell lung cancer: a comparative planning study. Technol Cancer
Res Treat. 2008 Feb;7(1):27-33.
51.
Prevost JB, Nuyttens JJ, Hoogeman MS, Poll JJ, van Dijk LC, Pattynama PM. Endovascular coils as
lung tumour markers in real-time tumour tracking stereotactic radiotherapy: preliminary results. Eur
Radiol. 2008 Aug;18(8):1569-76.
52.
Poll JJ, Hoogeman MS, Prevost JB, Nuyttens JJ, Levendag PC, Heijmen BJ. Reducing monitor units
for robotic radiosurgery by optimized use of multiple collimators. Med Phys. 2008 Jun;35(6):2294-9.
53.
Hoogeman MS, Nuyttens JJ, Levendag PC, Heijmen BJ. Time dependence of intrafraction patient
motion assessed by repeat stereoscopic imaging. Int J Radiat Oncol Biol Phys. 2008 Feb
1;70(2):609-18.
54.
Han X, Hoogeman MS, Levendag PC, Hibbard LS, Teguh DN, Voet P, et al. Atlas-based
auto-segmentation of head and neck CT images. Med Image Comput Comput Assist Interv.
2008;11(Pt 2):434-41.
55.
Ahmad R, Hoogeman MS, Quint S, Mens JW, de Pree I, Heijmen BJ. Inter-fraction bladder filling
variations and time trends for cervical cancer patients assessed with a portable 3-dimensional
ultrasound bladder scanner. Radiother Oncol. 2008 Nov;89(2):172-9.
56.
Nuyttens JJ, Prevost JB, Van der Voort van Zijp NC, Hoogeman M, Levendag PC. Curative
stereotactic robotic radiotherapy treatment for extracranial, extrapulmonary, extrahepatic, and
extraspinal tumors: technique, early results, and toxicity. Technol Cancer Res Treat. 2007
Dec;6(6):605-10.
57.
Nuver TT, Hoogeman MS, Remeijer P, van Herk M, Lebesque JV. An adaptive off-line procedure for
radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1559-67.
58.
Heemsbergen WD, Hoogeman MS, Witte MG, Peeters ST, Incrocci L, Lebesque JV. Increased risk of
biochemical and clinical failure for prostate patients with a large rectum at radiotherapy planning:
results from the Dutch trial of 68 GY versus 78 Gy. Int J Radiat Oncol Biol Phys. 2007 Apr
1;67(5):1418-24.
Prof. Gerard van Rhoon
School/De
partment:
Erasmus University Medical Center Rotterdam
Department of Radiation Oncology – Section Hyperthermia
(part of Erasmus MC research school Molmed)
The Netherlands
Project
Title:
Abstract:
Assessment of dielectric and thermal properties of human tissues and their impact in medical
applications
In modern medicine, patients are more and more exposed to electromagnetic fields (EMF).
Accurate knowledge of the dielectric and thermal properties of tissues is required to calculate the
energy deposition and thermal exposure of EMF during medical applications, such as Magnetic
Resonance Imaging (MRI) and cancer treatments using hyperthermia (heating of the tumor to
stimulate radiotherapy or drugs). Variations in tissue properties have a major impact on the EMF
and temperature patterns and, consequently, on the safety and quality of these medical
applications. Current tissue data is obtained by animals or samples from a limited number of
human post-mortem scans. We expect that the properties of living human tissues differ greatly
from those obtained in the existing literature. In addition, there are inter-patient variations
dependent on e.g. age, sex, tumor-type etc.
The goal of this project is to assess the variations in dielectric and thermal tissue properties, such
that it can be used to assess their impact in medical applications. Hereto, various tissue types will
be measured, both in-vivo and ex-vivo, by using different measurement methods, such as coaxial
probe and electric properties Tomography using MRI (EPT-MRI). In addition, numerical
modeling will be used to study the impact of the obtained variations on the exposure during MRI
examinations and hyperthermia treatments.
Requireme Background: Affinity with basic electromagnetism, medical applications and experimental work.
nts
of Master degree: Yes, Electrical / Biomedical Engineering, Physics or equivalent
candidate: IELTS Grade: 7.0 (min. 6.0 per sub-score)or
TOEFL: 100 (min. 20 per sub-score)
Other: good communicator
Supervisor Prof. Dr. G.C. Van Rhoon E-mail: g.c.vanrhoon@erasmusmc.nl
informatio The hyperthermia unit consists of about 10 highly motivated researchers from different countries
(Italy, Tsjech, Iran and The Netherlands) working on the development of hyperthermia. The
n:
research is highly translation and multidisciplinary of nature.
List of recent publications
1. Bakker JF, Paulides MM, Neufeld E, Christ A, Kuster N, van Rhoon GC. Children and
adults exposed to electromagnetic fields at the ICNIRP reference levels: theoretical
assessment of the induced peak temperature increase. Phys Med Biol. 2011 Aug
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
7;56(15):4967-89. Epub 2011 Jul 19.
Fatehi D, van der Zee J, van Rhoon GC. Intra-patient comparison between two annular
phased array applicators, Sigma-60 and Sigma-Eye: Applied RF powers and
intraluminally measured temperatures. Int. J. Hyperthermia, May 2011; 27(3): 214–223
van Rhoon GC, Aleman A, Kelfkens G, Kromhout H, van Leeuwen FE, Savelkoul HFJ,
Wadman WJ, van de Weerdt RDHJ, Zwamborn APM, van Rongen E, The
Electromagnetic Fields Committee of the Health Council of the Netherlands Health
Council of the Netherlands: No need to change from SAR to time-temperature relation
in electromagnetic fields exposure limits. Int. J. Hyperthermia, June 2011; 27(4):
399–404
de Bruijne M, van der Zee J, Ameziane A, van Rhoon GC. Quality control of
superficial hyperthermia by treatment evaluation. Int. J. Hyperthermia, May 2011; 27(3):
199–213
Canters RA, Franckena M, van der Zee J, van Rhoon GC. Optimizing deep
hyperthermia treatments: are locations of patient pain complaints correlated with
modelled SAR peak locations? Phys Med Biol. 2011 Jan 21;56(2):439-51. Epub 2010
Dec 22.
Van Der Zee J, De Bruijne M, Mens JW, Ameziane A, Broekmeyer-Reurink MP, Drizdal
T, Linthorst M, Van Rhoon GC. Reirradiation combined with hyperthermia in breast
cancer recurrences: overview of experience in Erasmus MC. Int J Hyperthermia.
2010;26(7):638-48.
de Bruijne M, van der Holt B, van Rhoon GC, van der Zee J. Evaluation of CEM43
degrees CT90 thermal dose in superficial hyperthermia: a retrospective analysis.
Strahlenther Onkol. 2010 Aug;186(8):436-43.
Bakker JF, Paulides MM, Christ A, Kuster N, van Rhoon GC. Assessment of induced
SAR in children exposed to electromagnetic plane waves between 10 MHz and 5.6 GHz.
Phys Med Biol. 2010 Jun 7;55(11):3115-30.
Paulides MM, Bakker JF, Linthorst M, van der Zee J, Rijnen Z, Neufeld E, Pattynama
PM, Jansen PP, Levendag PC, van Rhoon GC. The clinical feasibility of deep
hyperthermia treatment in the head and neck: new challenges for positioning and
temperature measurement. Phys Med Biol. 2010 May 7;55(9):2465-80.
Li L, ten Hagen TL, Schipper D, Wijnberg TM, van Rhoon GC, Eggermont AM,
Lindner LH, Koning GA. Triggered content release from optimized stealth
thermosensitive liposomes using mild hyperthermia. J Control Release. 2010 Apr
19;143(2):274-9.
Bakker JF, Paulides MM, Westra AH, Schippers H, Van Rhoon GC. Design and test of a
434 MHz multi-channel amplifier system for targeted hyperthermia applicators. Int J
Hyperthermia. 2010;26(2):158-70.
Franckena M, Canters R, Termorshuizen F, Van Der Zee J, Van Rhoon G. Clinical
implementation of hyperthermia treatment planning guided steering: A cross over trial to
assess its current contribution to treatment quality. Int J Hyperthermia.
2010;26(2):145-57.
Canters RA, Wust P, Bakker JF, van Rhoon GC. A literature survey on indicators for
characterisation and optimisation of SAR distributions in deep hyperthermia, a plea for
standardisation. Int J Hyperthermia. 2009 Nov;25(7):593-608
Franckena M, Fatehi D, de Bruijne M, Canters RAM, van Norden Y, Mens JW, van
15.
16.
17.
18.
19.
20.
Rhoon GC and van der Zee J. Hyperthermia dose-effect relationship in 420 patients with
cervical cancer treated with combined radiotherapy and hyperthermia. Eur J Cancer.
2009 Jul;45(11):1969-78. Epub 2009 Apr 8.
Canters RA, Franckena M, Paulides MM, van Rhoon GC. Patient positioning in deep
hyperthermia: influences of inaccuracies, signal correction possibilities and optimization
potential. Phys Med Biol. 2009 Jun 21;54(12):3923-36. Epub 2009 Jun 2.
Bakker JF, Paulides MM, Obdeijn IM, van Rhoon GC and van Dongen KWA. An
ultrasound cylindrical phased array for deep heating in the breast: theoretical design
using heterogeneous models. Phys. Med. Biol. 54 (2009) 3201–3215
Fatehi D, van der Zee J, van Rhoon GC. Hyperthermia: A New Cancer Treatment
Modality. Journal of Isfahan Medical School Vol 27, No 94, June 2009
Franckena M, Lutgens LC, Koper PC, Kleynen CE, van der Steen-Banasik EM, Jobsen
JJ, Leer JW, Creutzberg CL, Dielwart MF, van Norden Y, Canters RA, van Rhoon GC,
van der Zee J. Radiotherapy and hyperthermia for treatment of primary locally
advanced cervix cancer: results in 378 patients. Int J Radiat Oncol Biol Phys. 2009 Jan
1;73(1):242-50. Epub 2008 Nov 5.
Wal E van der, Franckena M, Wielheesen DH, van der Zee J, van Rhoon GC. Steering in
locoregional deep hyperthermia: evaluation of common practice with 3D-planning. Int J
Hyperthermia. 2008 Dec;24(8):682-93.
Canters RA, Franckena M, van der Zee J, van Rhoon GC. Complaint-adaptive power
density optimization as a tool for HTP-guided steering in deep hyperthermia treatment
of pelvic tumors. Phys Med Biol. 2008 Dec 7;53(23):6799-820.
Prof. Hans van der Steen
School/Dep
artment:
Erasmus University Medical Centre Rotterdam
Department of Neuroscience
The Netherlands
Project Title:
Eye-hand coordination: hands on neurodegenerative diseases
Abstract:
Recently we developed a device that provides an objective measure of degradation of
motor performance in elderly people. Quantification of motor performance decline builds
on current knowledge on the causes of neuro-degenerative diseases and current insight in
the neural substrate of the sensorimotor pathways.
Objective and quantifiable behavioural marker data, e.g. relative latencies between eye and
head, and execution speed of eye and hands provide a direct insight in the behavioral motor
performance of a given subject. Pilot data show that motor coordination allows not only to
discriminate between different forms of neurodegenerative diseases at an early stage, but
also to monitor progression of the disease.
Collaboration is planned between Dutch en Chinese research teams to make a comparison
of mutually collected behavioural marker data to clinical observations and biomarker data,
to optimize and validate this technique in a Dutch and Chinese clinical setting. In addition,
we will utilize the multi-disciplinary expertise from neurologists, geriatrists,
neurophysiologists and engineers to develop a decision model to predict the course and
time path of motor performance decline in elderly people suffering from neurodegenerative diseases.
Requiremen Background:
ts
of The candidate should have:
A strong theoretical and practical background in Neurology
candidate:
AND interest in health technology engineering.
Expertise in programming in Matlab,
Preferably also mathematical and modeling expertise
Social skills to work with patients.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information
:
Supervisor: Prof. dr. / Dr. J van der Steen
Email: j.vandersteen@erasmusmc.nl Personal website : www.neuro.nl
Current Research
The focus is on sensorimotor integration with special interest on plasticity in vestibular
ocular reflexes, visual development, binocular vision and cognitive aspects of visually and
memory
guided motor behaviour (e.g. eye-hand coordination) in healthy humans and in patient
populations.
Visual development: We developed a new method to quantify normal and abnormal visual
development in children from the age of 4 months. With this method, children with
cerebral visual impairments (CVI), cerebral palsy (CP) and intellectual disabilities are
tested for visual information processing disorders related
to abnormal brain development. In collaboration with the dept. of neonatology, we will also
start a study to relate functional development on visual function to DTI brain imaging in a
cohort of prematurely born children.
Visual function: Recently we developed and did a feasibility study for a method to
quantify field defects in glaucoma patients based on eye movement responses. Following
up on this line of research, we have started a collaboration with the Rotterdam Eye
Hospital and the Vision Research Centre, Chennai, India in project aimed to the early
detection of glaucoma.
Vestibular function: The research on vestibular problems focuses on the central
organization of spatial memory and the role of visual and vestibular information on
updating. In addition,
we advise on a population study performed by ENT on vestibular problems in the elderly,
measure “special cases” of patients with vestibular problems
Eye-hand coordination. We use eye-hand coordination parameters to quantify motor
coordination impairments in patients with Alzheimer, Lewy Body dementia, progressive
supranuclear palsy (PSP) and Parkinson. In this study we collaborate with depts.
Neurology and Geriatry. In collaboration with Jiao Tong University, Shanghai and
Aerospace department, TU Delft we applied for NWO-JSTP grant to investigate to what
extentbiomarker (Tau, alpha-synuclein) levels correlate to motor coordination impairments.
List of recent publications
Goossens HH, Hoebeek FE, Van Alphen AM, Van Der Steen J, Stahl JS, De Zeeuw
CI, Frens MA. (2004). Simple spike and complex spike activity of floccular Purkinje
cells during the optokinetic reflex in mice lacking cerebellar long-term depression. Eur.
J. Neurosci. 19(3):687-97.
Van der Steen J., Goumans J., deJongste A.H.C. and Houben M.M.J. (2005).
Angular and Linear vestibulo-ocular responses in humans. Ann. NY Acad. Sci.
1039:68-80.
Goumans J., Boumans L.J.J.L.M., Van der Steen J., Feenstra L. (2004). Het
superior canaldehiscence syndroom. Ned. Tijdschrift voor Geneeskunde.
149(24):1320-1325.
Houben M.M.J., Goumans J. and Van der Steen J. (2006) Recording three
dimensional eye movements: scleral search coils versus video-oculography. Invest
Ophth Vis Sci. 2006;47:179-187
Van der Steen J (2009) The vestibulo-ocular reflex . In Springer Encyclopedia
Neuroscience.
Pel J J M; Bagheri J; van Dam L M; van den Berg-Emons H J G; Horemans H L
D; Stam H J; van der Steen J (2009) Platform accelerations of three different
whole-body vibration
devices and the transmission of vertical vibrations to the lower limbs
Goumans J; Houben M M J; Dits J; van der Steen J. (2010) Peaks and troughs of
threedimensional vestibulo-ocular reflex in humans. Journal of the Association for
Research in Otolaryngology : JARO;11(3):383-93.
Pel J J M; Manders J C W; van der Steen J (2010) Assessment of visual orienting
behaviour in young children using remote eye tracking: methodology and reliability.
Journal of neuroscience methods; 189(2): 252-6.
Boot FH, Pel JJ, van der Steen J, Evenhuis HM. Cerebral Visual Impairment: which
perceptive visual dysfunctions can be expected in children with brain damage? A
systematic review. Res Dev Disabil. 2010 Nov-Dec;31(6):1149-59. Epub 2010 Sep 6.
Pel JJ, van der Does JM, Boot FH, de Faber JT, van der Steen-Kant SP,
Willemsen SP, van der Steen J. Effects of visual processing and congenital
nystagmus on visually guided ocular motor behaviour. Dev Med Child Neurol.
53(4):344-9. Epub 2010 Dec 17.
Boot FH, Pel JJ, Evenhuis HM, van der Steen J. Quantification of visual orienting
responses to form and motion stimuli in healthy children aged 0-12 years using remote
eye tracking. (under revision).
Prof. Meijering
School/Dep
artment:
Erasmus University Medical Center Rotterdam
Departments of Medical Informatics and Radiology
Dept. Biomedical Imaging Group Rotterdam (BIGR) www.bigr.nl
The Netherlands
Project
Title:
Abstract:
Advanced Algorithms for Cell Tracking and Motion Analysis in Microscopy Movies
Cells are the fundamental units of biological life. The proliferation, differentiation, and
migration of cells are essential processes in the conception, development, and maintenance
of any living organism. These processes also play a crucial role in the onset and
progression of many diseases. It is very important to understand how these processes work
in order to develop effective drugs.
Live cell imaging experiments produce enormous amounts of image data (3D/4D/5D)
containing much more information than can be analyzed by humans. Computerized image
analysis can help to take full advantage of the data in an efficient and reproducible manner.
An important task in many experiments is the tracking of large numbers of cells and the
automated analysis of their (morpho)dynamic behavior.
The goal of this project is to develop and test advanced high-throughput image analysis
algorithms to automatically track and analyze the motion and shape changes of large
numbers of moving cells in microscopy movies.
This is a challenging problem, since the image quality is often poor (low contrast and high
noise levels), the density of cell populations may vary a lot due to cell division and cells
entering or leaving the field of view, and cells may touch each other without showing
sufficient image contrast.
Existing algorithms for cell tracking are usually based on a two-step approach: (1)
detection and segmentation of cells in each image of a movie, and (2) linking the detected
cells between frames. In this project, the goal is to develop an integrated and probabilistic
method for this.
Requirement Background:
s
of Experience with biomedical image analysis is an advantage Experience with computer
programming (Java or C++), strong theoretical skills, communication skills (English), and
candidate:
the ability to work in a multi-disciplinary team (involving both computer scientists and
biologists) are required
Master degree: MSc degree in mathematics, physics, electrical engineering, biomedical
engineering, computer science, or a related field.
IELTS: 7.0 (min. 6.0 per sub-score)
Supervisor: Ass. Prof. dr. E. Meijering, Associate Professor of Bio-image Analysis
Supervisor
information: E-mail: meijering@imagescience.org
Website: http://www.imagescience.org/meijering/
Recent publication list:
5. E. Meijering, O. Dzyubachyk, I. Smal (2011). Methods for Cell and Particle Tracking.
Methods in Enzymology: Live Cell Imaging, in press.
6. O. Dzyubachyk, J. Essers, W. A. van Cappellen, C. Baldeyron, A. Inagaki, W. J.
Niessen, E. Meijering (2010). Automated Analysis of Time-Lapse Fluorescence
Microscopy Images: From Live Cell Images to Intracellular Foci. Bioinformatics
26(19):2424-2430.
7. E. Meijering, O. Dzyubachyk, I. Smal, W. A. van Cappellen (2009). Tracking in Cell
and Developmental Biology. Seminars in Cell and Developmental Biology
20(8):894-902.
8. I. Smal, K. Draegestein, N. Galjart, W. Niessen, E. Meijering (2008). Particle Filtering
for Multiple Object Tracking in Dynamic Fluorescence Microscopy Images:
Application to Microtubule Growth Analysis. IEEE Transactions on Medical Imaging
27(6):789-804.
Institute of Health Policy and Management
Ernst Hulst
School/Dep
artment:
Institute of Health Policy and Management (iBMG)
Erasmus University Rotterdam The Netherlands
Project Title:
Embryos
Abstract:
The innovative power of China is immense
Many believe research advancement requires new embryonic stem cell lines, and for
certain applications, stem cells derived from cloned embryos may offer the best hope for
understanding and treating disease. It’s considered to be the most promising innovation in
medicine. Scientists hope to find new therapies for diseases which are still incurable, such
as blindness, devastating brain diseases such as Alzheimer. It could also offer solutions for
the need for organs and maybe become a good substitute for organ donation with all its
problems of medical and ethical nature.
But actual developments in (case-)law seem to oppose scientific research. For example, in
some countries stem cell research is limited to adult stem cells obtained from tissues such
as bone marrow. Other legislations also permit the use of rest-embryos and some countries
even allow the use of stem cells of embryos created for this specific purpose. From a
technical point of view creation of embryos offers the best opportunities for scientific
research. But many consider this to be against human values. Each embryo is a human
being and for this reason it is against human dignity and human rights to create an embryo
for only one purpose, namely to be sacrificed for scientifical reasons. In this opinion even
saving lives does not justify the sacrificing of embryos.
But there are more principles, such as the principle of freedom of research and the principle
of progress, which state that restraints on scientific research are inherently offensive and
generally unjustifiable and that we have a right to acquire new knowledge.
This PhD-research project will address the controversy between the progression of
medicine by bio-medical scientific research of Human embryonic stem cell research and its
promises for better and more effective medicine while considering the rights and diginity
of human embryos.
This project includes an in-depth analysis of the current case-law on human rights,
especially the right to live in relation with unborn human life.
Furthermore, it will examine the impact of biomedical ethical standards on the status of
human embryos and what medical and ethical notions and considerations there are on
manipulation with human embryos.
This research is first and for all aimed at the development of a set of internationally shared
principles on biomedical research and manipulation of human embryonic stem cells in
order to improve medicine and its contribution to the quality of life.
Requirement Background: Master of Laws (LLM); with special interest in Health Ethics.
s
of Master degree: Yes
IELTS Grade: 7 (min 6.0 per sub-score)Or
candidate:
TOEFL Grade: 100(min 20 per sub-score)
Ernst Hulst Lecturer of Health Law
Supervisor
information: E-mail: hulst@bmg.eur.nl Website: www.bmg.eur.nl
Prof. Joris van de Klundert
School/Dep
artment:
Project
Title:
Abstract:
Institute of Health Policy & Management
Erasmus University Rotterdam The Netherlands
Application of Operations Research to improve coordination in health service chains
Coordination mechanisms in networks of health services organizations become
increasingly important in European countries. Whether patients have access to affordable
health services of high quality not only depends on the efforts of independent professionals
and organizations, but rather on the joint achievements of networked organizations and
professionals. Such networks are referred to as health service value chains.
To design health systems that ensure access to affordable health services of high quality
therefore requires a deepened understanding of how the coordination between independent
organizations, private and public, affects costs and health outcomes. We research
coordination mechanisms in health service value chains, i.e. agreements on methods of
interaction between two or more value chain partners, one of which might be government.
The agreements are explicit or implicit and deal with issues such as price, quality, and
accessibility for various specific types of services. A subsequent research question
addresses how coordination mechanisms can optimally contribute to accessible and
affordable health services of high quality.
The research will consist of analyzing current state, developing models to describe
coordination in health service networks, and applying game theory to formulate
improvements and optimal structures for providing high quality health care against low
costs.
Requiremen Background: The ideal candidate has a strong background in Applied Mathematics,
ts
of Operations Research or Management Science and a strong interest in health care
applications. Especially knowledge of and interests in supply chain management, network
candidate:
optimization and game theory, are appreciated. The candidate is able to link processes and
behavior of health service providers to analytical models.
Master degree: Operations Research, Applied Mathematics or equivalent
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
GMAT/GRE: 600
Supervisor
information
:
Prof. dr. ir. Joris van de Klundert – vandeklundert@bmg.eur.nl
Dr.ir. Jeroen van Oostrum – vanoostrum@bmg.eur.nl –
List of selected publications
Crama, Y. Klundert, J.J. van de, 1997
Cyclic Scheduling of identical parts in a robotic cell,
Operations Research, 952-965.
Leensel, R. van de, Hoesel, C.P.M. van, Klundert, J.J. van de, 1999.
The complexity of lifting facets of the precedence constraint knapsack polytope
Mathematical Programming, series A 86, pp 161-185,
Crama, Y., Klundert, J.J. van de, Spieksma, 2002
Production planning problems in printed circuit board assembly,
Discrete Applied Mathematics, 123(1-3), pp. 339-361.
Klundert, J.J. van de, Kuipers. J., Spieksma, F.C.R., Winkels, M., 2005
Telecommunication Carriers Selection under Volume Discounts,
Interfaces, Vol. 35, No. 2, pp 124-132.
Optimizing sterilization Logistics in Hospitals, Joris van de Klundert · Philippe Muls ·
Maarten Schadd, Health Care Management Science, Volume 11, Number 1 / March, 2008
DOI10.1007/s10729-007-9037-4, Pages23-33
Grigoriev A., Van De Klundert J., Spieksma F.
Modelling and solving the periodic maintenance problem.
European Journal of Operational Research 172, No. 3, pp. 783-797, 2006.
Joris van de Klundert & Laurens Wormer, ASAP: The After Salesman Problem, Manufacturing
& Service Operations Management, 2010. (to appear)
Klundert, J.J. van de, Gorissen, P., Zemmering, S., Measuring Clinical Pathway Adherence,
Journal of Biomedical Informatics, 2010 (to appear).
Prof. Martin Buijsen 1
School/Dep
artment:
Institute of Health Policy and Management (iBMG)
Erasmus University Rotterdam
The Netherlands
Project Title:
Equal Access to Health Care in China under the new Social Insurance Law
Abstract:
China’s economic reforms over the past decades have met tremendous success. However,
this economic growth has not resulted in better health and health care in China. Healthcare
has been largely neglected, as the responsibility for providing comprehensive healthcare
shifted away from state-owned enterprises and successful rural programs were dismantled
without establishing an alternative system.
Inadequate spending is only part of the problem. Just as serious is the lack of equal access
to affordable healthcare, and the lack of high-quality patient care. These challenges are
compounded by the immense size of China’s population.
Recently (July 2011) China’s Social Insurance Law came into force. The new law specifies
a common right for all citizens to access to several forms of insurance, including basic
health insurance. Introducing a universal health insurance scheme for the entire population
is one of the key challenges to provide equitable, affordable, yet high-quality patient care.
Though the new law will likely improve access to affordable health care services, several
main challenges remain, like equity disparities between rural and urban communities, and
the lack of high-quality medical care. Furthermore, given the ageing population and rising
costs of healthcare, it can be expected that the rationing or priority setting debate will
emerge very soon. Also, in order to guarantee the sustainability of the health insurance
scheme, new mechanisms like risk pooling, medical saving accounts, etc. need to be
considered. Finally, since the mandatory health insurance scheme will be limited to basic
health care services, the introduction of complementary (private) health insurance may be
considered.
Both in terms of international human rights law and international social security law, it is
crucial to analyze how the new law will realize equal access to health care and whether the
suggested mechanisms are effective, and in line with international standards concerning the
right to health.
Requirement Background: Master of Laws (LL M); with special interest in Health law and/or Social
s
of insurance law
Master degree: Yes
candidate:
IELTS Grade: 7 (min. 6.0 per sub-score) Or
TOEFL Grade: 100(min. 20 per sub-score)
Prof. dr. Martin Buijsen
Supervisor
information: Professor of Health Law
E-mail: buijsen@bmg.eur.nl
Contact: denexter@bmg.eur.nl Website: www.bmg.eur.nl
Book reviews
1. S. Fleischacker, A Short History of Distributive Justice, in: Nederlands Tijdschrift voor
Rechtsfilosofie en Rechtstheorie 2006/1, p. 75-82.
2. Chris Gastmans e.a. (ed.), New Pathways for European Bioethics, in: Tijdschrift voor
Gezondheidszorg en Ethiek 2008/2, p. 127-128.
3. Craig Paterson, Assisted Suicide and Euthanasia. A Natural Law Approach, in:
Medicine, Health Care & Philosophy 2008/4, p. 492.
4. M. Powers & R. Faden, Social Justice. The moral foundations of public health and
health policy, in: Medicine, Health Care & Philosophy 2009/3, p. 365-366.
5. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Tijdschrift voor gezondheidszorg en ethiek 2009/4, p. 123.
6. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Medicine, Health Care & Philosophy 2010/1, p. 97-98.
List of recent publications
1. M. Buijsen, ‘Autonomy, Human Dignity and The Right to Health Care. A Dutch
Perspective’, in: Cambridge Quarterly of Health Care Ethics 2010/3, p. 321-329.
2. M. Buijsen, ‘Equality and the Right to Health Care’, in: A. den Exter (ed.) Human
Rights and Biomedicine, Maklu, Antwerpen 2009, p. 69-86.
3. M. Buijsen, ‘The meaning of “Justice” in Health Care’, in: Medicine & Law 2008/3, p.
535-546.
4. M. Buijsen, ‘The meaning of “Justice” and “Solidarity” in Health Care’, in: A.P. den
Exter (red.) International Health Law. Solidarity and Justice in Health Care, MAKLU,
Antwerpen/Apeldoorn 2008, p. 51-61.
5. M. Buijsen, ‘Biolaw in the Netherlands: recent developments’, in: Diritto Pubblico
Comparato ed Europeo, 2007-IV, p. 1686-1699.
Books and book chapters
1. Martin Buijsen, André den Exter, Bert Hermans, The Netherlands, in: prof.dr. R.
Blanpain (gen. ed.) International Encyclopedia of Laws, Kluwer Law International
2006, 126pp.
Prof. Martin Buijsen 2
School/Dep
artment:
Institute of Health Policy and Management (iBMG)
Erasmus University Rotterdam The Netherlands
Project Title:
China and the WHO Framework Convention on Tobacco Control
Abstract:
Negotiated under the auspices of the World Health Organization, the Framework
Convention on Tobacco Control entered into force on February 27, 2005. According to the
Preamble, the treaty seeks to “protect present and future generations from the devastating
health, social, environmental and economic consequences of tobacco consumption and
exposure to tobacco smoke.”
Since China’s ratification of the FCTC in 2005, it should have implemented a wide scope
of measures fighting the use of tobacco. Despite some successes the 2010 China Tobacco
Control Report states that the country still has more than 1 million people dying of
smoke-related diseases each year. The Report criticizes the lack of effective regulation to
fight the tobacco epidemic in China. Coping with that problem, several countries are
successfully integrating a human rights approach in tobacco control. Human rights law (the
right to health, the right to life, consumer rights) is one of the most powerful legal tools
that can be used both domestically and internationally. Moreover, human rights are also
widely used in political discourse and they usually influence policy debates. Despite its
utility, a human rights approach to advance tobacco control policies has not been widely
used by the tobacco control movement. In fact, one could argue that the powerful tobacco
industry has been more proactive in using human rights law to attack tobacco control
policies.
This research proposal is aimed to analyze the connections between human rights law and
tobacco control. Case study research in several selected countries will explain how such a
human rights approach can be used in China’s tobacco control.
Requirement Background: Master of Laws (LLM); with special interest in (Public) Health law
s
of Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) or
candidate:
TOEFL Grade: 100(min. 20 per sub-score)
Prof. dr. Martin Buijsen
Supervisor
information: Professor of Health Law
E-mail: buijsen@bmg.eur.nl
Contact: denexter@bmg.eur.nl Website: www.bmg.eur.nl
Book reviews
7. S. Fleischacker, A Short History of Distributive Justice, in: Nederlands Tijdschrift voor
Rechtsfilosofie en Rechtstheorie 2006/1, p. 75-82.
8. Chris Gastmans e.a. (ed.), New Pathways for European Bioethics, in: Tijdschrift voor
Gezondheidszorg en Ethiek 2008/2, p. 127-128.
9. Craig Paterson, Assisted Suicide and Euthanasia. A Natural Law Approach, in:
Medicine, Health Care & Philosophy 2008/4, p. 492.
10. M. Powers & R. Faden, Social Justice. The moral foundations of public health and
health policy, in: Medicine, Health Care & Philosophy 2009/3, p. 365-366.
11. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Tijdschrift voor gezondheidszorg en ethiek 2009/4, p. 123.
12. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Medicine, Health Care & Philosophy 2010/1, p. 97-98.
List of recent publications
6. M. Buijsen, ‘Autonomy, Human Dignity and The Right to Health Care. A Dutch
Perspective’, in: Cambridge Quarterly of Health Care Ethics 2010/3, p. 321-329.
7. M. Buijsen, ‘Equality and the Right to Health Care’, in: A. den Exter (ed.) Human
Rights and Biomedicine, Maklu, Antwerpen 2009, p. 69-86.
8. M. Buijsen, ‘The meaning of “Justice” in Health Care’, in: Medicine & Law 2008/3, p.
535-546.
9. M. Buijsen, ‘The meaning of “Justice” and “Solidarity” in Health Care’, in: A.P. den
Exter (red.) International Health Law. Solidarity and Justice in Health Care, MAKLU,
Antwerpen/Apeldoorn 2008, p. 51-61.
10. M. Buijsen, ‘Biolaw in the Netherlands: recent developments’, in: Diritto Pubblico
Comparato ed Europeo, 2007-IV, p. 1686-1699.
Books and book chapters
Martin Buijsen, André den Exter, Bert Hermans, The Netherlands, in: prof.dr. R.
Blanpain (gen. ed.) International Encyclopedia of Laws, Kluwer Law International 2006,
126pp.
Erasmus School of Law
Prof. Martin Buijsen 1
School/Dep
artment:
Erasmus School of Law (ESL)
Erasmus University Rotterdam The Netherlands
Project Title:
Justiciability of the Right to Healthcare in China
Abstract:
One of the neglected issues regarding the right to healthcare concerns the justiciability, i.e.
the possibility to file a complaint at an impartial body and request adequate remedies in
case of a violation. Worldwide, there has been a passionate debate regarding the issue of
justiciability of social rights. Based on empirical and doctrinal evidence, it is assumed that
these rights are partially suitable for judicial enforcement. Though judicial adjudication
cannot be the only means to fully realise the healthcare right, it should play some role in
this area: giving voice to right-holders and offering them forms of reparation in case of
violation, subjecting duty-bearers to control in case of failure to comply with their legal
duties, and channelling the idea of mutual control of powers. The complete absence of any
resource to courts in relation to this right will weaken state accountability, erodes
deterrence and fosters impunity. If the right to healthcare is to be considered in a
meaningful way, the above mentioned considerations should apply to it. The diversity of
actors (state authorities, insurers, health professionals) and situations, and “levels of duties”
open up opportunities for justiciability. Then the main question is: ‘what are the
implications of the justiciability of a healthcare right for (non)state actors taking into
account advantages and disadvantages vis-a-vis other potential strategies for exigibility?
As such, this analysis should explore the role of justiciability in realizing the healthcare
right in China.
Requirement Background: Master of Laws (LLM); with special interest in Health law and/or
s
of International law
Master degree: Yes
candidate:
IELTS Grade: 7 (min. 6.0 per sub-score) or
TOEFL Grade: 100(min. 20 per sub-score)
Prof. dr. Martin Buijsen Professor of Health Law
Supervisor
information: E-mail: buijsen@bmg.eur.nl
Contact: denexter@bmg.eur.nl Website: www.bmg.eur.nl
Book reviews
13. S. Fleischacker, A Short History of Distributive Justice, in: Nederlands Tijdschrift voor
Rechtsfilosofie en Rechtstheorie 2006/1, p. 75-82.
14. Chris Gastmans e.a. (ed.), New Pathways for European Bioethics, in: Tijdschrift voor
Gezondheidszorg en Ethiek 2008/2, p. 127-128.
15. Craig Paterson, Assisted Suicide and Euthanasia. A Natural Law Approach, in:
Medicine, Health Care & Philosophy 2008/4, p. 492.
16. M. Powers & R. Faden, Social Justice. The moral foundations of public health and
health policy, in: Medicine, Health Care & Philosophy 2009/3, p. 365-366.
17. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Tijdschrift voor gezondheidszorg en ethiek 2009/4, p. 123.
18. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Medicine, Health Care & Philosophy 2010/1, p. 97-98.
List of recent publications
11. M. Buijsen, ‘Autonomy, Human Dignity and The Right to Health Care. A Dutch
Perspective’, in: Cambridge Quarterly of Health Care Ethics 2010/3, p. 321-329.
12. M. Buijsen, ‘Equality and the Right to Health Care’, in: A. den Exter (ed.) Human
Rights and Biomedicine, Maklu, Antwerpen 2009, p. 69-86.
13. M. Buijsen, ‘The meaning of “Justice” in Health Care’, in: Medicine & Law 2008/3, p.
535-546.
14. M. Buijsen, ‘The meaning of “Justice” and “Solidarity” in Health Care’, in: A.P. den
Exter (red.) International Health Law. Solidarity and Justice in Health Care, MAKLU,
Antwerpen/Apeldoorn 2008, p. 51-61.
15. M. Buijsen, ‘Biolaw in the Netherlands: recent developments’, in: Diritto Pubblico
Comparato ed Europeo, 2007-IV, p. 1686-1699.
Books and book chapters
Martin Buijsen, André den Exter, Bert Hermans, The Netherlands, in: prof.dr. R.
Blanpain (gen. ed.) International Encyclopedia of Laws, Kluwer Law International 2006,
126pp.
Prof. Martin Buijsen 2
School/De
partment:
Erasmus School of Law (ESL)
Erasmus University Rotterdam
The Netherlands
Project
Title:
Abstract:
A comparative study of orphan medicines regulation in the US, European Union and Japan:
Towards a made-in-China orphan medicines regulatory framework
Orphan medicinal products (OMP) are intended for treatment of life-threatening conditions
that are rare. Under normal market conditions, the pharmaceutical industry is reluctant to
invest for rare conditions because of the very limited market for each disease. Therefore, rare
diseases constitute a medical problem deserving serious societal and scientific attention.
In several countries – the United States, the European Union and Japan – specific legislation
has been enacted to encourage pharmaceutical companies to expedite the development of
medicines for rare diseases, and to assure access to these orphan medicines. Incentives
include market exclusivity, tax credits, fee reduction, as well as fast track approval, plus
research & development support from the governments.
But there is evidence that the effectiveness of the existing regulatory framework in these
countries needs improvement, particularly in terms of patient access. A common problem
concerns inequities in access to orphan medicines, also access to care vary greatly per
disease. Enhancing legislation’s effectiveness could secure equal access to orphan medicines.
But obstacles in orphan medicines accessibility are also related to orphan pricing and
reimbursement policies. How the United States, EU member states, and Japan approaches
this issue is meaningful for China.
According to the World Health Organization, at least 10 million people in China live with
rare diseases whereas very few orphan medicines have entered the Chinese market. Recent
shortages to orphan medicines in China have raised concerns about the availabity of
treatment of these diseases. Therefore, legislation protecting rare diseases patients is under
consideration in the National’s People’s Congress. Such legislation may incorporate
experiences of and best practices from other countries, hopefully finding the best way for
China to approach the problems of orphan medicines.
This cross-national comparative research on orphan medicines legislation should formulate
suggestions for a made-in-China orphan medicines regulatory regime.
Requireme Background: Master of Laws (LLM); with special interest in Health law and/or
nts
of Pharmaceutical law
candidate: Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) Or
TOEFL Grade: 100(min. 20 per sub-score)
Supervisor Prof. dr. Martin Buijsen Professor of Health Law
informatio E-mail: buijsen@bmg.eur.nl Contact: denexter@bmg.eur.nl
Website: www.bmg.eur.nl
n:
Book reviews
19. S. Fleischacker, A Short History of Distributive Justice, in: Nederlands Tijdschrift voor
Rechtsfilosofie en Rechtstheorie 2006/1, p. 75-82.
20. Chris Gastmans e.a. (ed.), New Pathways for European Bioethics, in: Tijdschrift voor
Gezondheidszorg en Ethiek 2008/2, p. 127-128.
21. Craig Paterson, Assisted Suicide and Euthanasia. A Natural Law Approach, in:
Medicine, Health Care & Philosophy 2008/4, p. 492.
22. M. Powers & R. Faden, Social Justice. The moral foundations of public health and
health policy, in: Medicine, Health Care & Philosophy 2009/3, p. 365-366.
23. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Tijdschrift voor gezondheidszorg en ethiek 2009/4, p. 123.
24. Leonard M. Fleck, Just Caring. Health care rationing and democratic deliberation, in:
Medicine, Health Care & Philosophy 2010/1, p. 97-98.
List of recent publications
16. M. Buijsen, ‘Autonomy, Human Dignity and The Right to Health Care. A Dutch
Perspective’, in: Cambridge Quarterly of Health Care Ethics 2010/3, p. 321-329.
17. M. Buijsen, ‘Equality and the Right to Health Care’, in: A. den Exter (ed.) Human Rights
and Biomedicine, Maklu, Antwerpen 2009, p. 69-86.
18. M. Buijsen, ‘The meaning of “Justice” in Health Care’, in: Medicine & Law 2008/3, p.
535-546.
19. M. Buijsen, ‘The meaning of “Justice” and “Solidarity” in Health Care’, in: A.P. den
Exter (red.) International Health Law. Solidarity and Justice in Health Care, MAKLU,
Antwerpen/Apeldoorn 2008, p. 51-61.
20. M. Buijsen, ‘Biolaw in the Netherlands: recent developments’, in: Diritto Pubblico
Comparato ed Europeo, 2007-IV, p. 1686-1699.
Books and book chapters
Martin Buijsen, André den Exter, Bert Hermans, The Netherlands, in: prof.dr. R. Blanpain
(gen. ed.) International Encyclopedia of Laws, Kluwer Law International 2006, 126pp.
Rotterdam School of Management
Dr. Nishant Mishra 1
School/Depa
rtment:
Rotterdam School of Management
Department of Management of Technology and Innovation
Operations Management Group Erasmus University Rotterdam
The Netherlands
Project Title:
Decision models in sustainable operations and closed loop supply chains
Abstract:
The PhD project is intended to look at specific decision problems that arise for companies and
regulators in the broad area of sustainable operations management. The project is expected to be
modeling focused, touching upon various topics such as sustainability, carbon markets, vehicle
routing and closed loop supply chains. The analysis part will involve using tools from
optimization, probability theory and also software skills to do numerical and data analysis.
Requirements
of candidate:
Background: strong quantitative background; preferably a bachelor’s and / or a master’s degree in
industrial engineering, operations research, mathematics or computer science; good English
language skills; good GMAT or GRE test score
Master degree: Yes
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
or
TOEFL: 100 (min. 20 per sub-score)
GMAT (or GRE): 85% or more
Other: preferably has taken courses in algebra, optimization (linear and non-linear), stochastic
processes, statistics and game theory
In addition to these formal requirements, candidates for the Programme will be selected based on
their CVs, academic references, and interview(s) with the potential supervisor(s)
Supervisor
information:
Primary Supervisor: Dr. Nishant Mishra
Email: nmishra@rsm.nl
Website: http://www.rsm.nl/nmishra
Bio: Nishant Mishra is an Assistant Professor of Operations Management at the Rotterdam
School of Management, Erasmus University. He received his M.S. in Operations Research from
the University at Buffalo, SUNY, USA and his PhD in Management Science and Operations from
the London Business School, UK. Nishant’s expertise is in the application of quantitative models
to problems in Revenue Management, Supply Chain Management and competition modeling in
other situations.
Co-Supervisor: Dr. René de Koster
Email: rkoster@rsm.nl
Website: http://www.rsm.nl/rdekoster
Bio: René (M.) B.M. de Koster is a professor of Logistics and Operations Management at
Rotterdam School of Management, Erasmus University since 1995. He holds a PhD from
Eindhoven University of Technology (1988). His research interests are warehousing, material
handling, supply chain management, retail operations and reverse logistics. He is author / editor
of 8 books and over 100 papers in books and academic journals. He is in the editorial boards of 5
academic journals and fellow in two research schools. He is member of the ELA R&D board,
member or chairman of 3 national logistics awards, and the chairman of Stichting Logistica.
List of recent publications and working papers:
N. Mishra and V. DeMiguel, “What Multistage Stochastic Programming Can Do for Network
Revenue Management”, under review, 2011.
N. Mishra and D. Li, “A comparison of Performance-based and Transaction-based contracts in
after-sales service supply chains”, RSM working paper, 2011.
Chen, C.M., Gong, Y., Koster, M.B.M. de & Nunen, J.A.E.E. van (2010), “A fexible evaluative
framework for order picking systems”, Production and Operations Management, 19(1), 70-82.
Quak, H.J. & Koster, René de (2009), “Delivering goods in urban areas. How to deal with urban
policy restrictions and the environment?”, Transportation Science, 43(2), 211-227.
De Koster, M.B.M., Balk, B.M. (2008), “Benchmarking and monitoring international
warehouse operations in Europe”, Production and Operations Management 17(2), 1-10.
Dr. Nishant Mishra 2
School/Department:
Rotterdam School of Management
Department of Management of Technology and Innovation
Operations Management Group
(RSM is consistently ranked as a top 10 business school in Europe)
Erasmus University Rotterdam
The Netherlands
Project Title:
Decision models in supply chain finance
Abstract:
The PhD project is intended to look at specific decision problems that arise for
companies in the emerging area of supply chain finance. The project is expected
to be modeling focused, touching upon various topics such as inventory
management, purchasing management and procurement, and finance. The
analysis part will involve using tools from optimization, probability theory and
also software skills to do numerical and data analysis.
Requirements of candidate:
Background: strong quantitative background; preferably a bachelor’s and / or a
master’s degree in industrial engineering, operations research, mathematics or
computer science; good English language skills; good GMAT or GRE test score
Master degree: Yes
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
or
TOEFL: 100 (min. 20 per sub-score)
GMAT (or GRE): 85% or more
Other: preferably has taken courses in algebra, optimization (linear and
non-linear), stochastic processes, statistics and game theory
In addition to these formal requirements, candidates for the Programme will be
selected based on their CVs, academic references, and interview(s) with the
potential supervisor(s)
Supervisor information:
Primary Supervisor: Ass. Prof. dr. Nishant Mishra
Email: nmishra@rsm.nl
Website: http://www.rsm.nl/nmishra
Bio: Nishant Mishra is an Assistant Professor of Operations Management at the
Rotterdam School of Management, Erasmus University. He received his M.S. in
Operations Research from the University at Buffalo, SUNY, USA and his PhD
in Management Science and Operations from the London Business School, UK.
Nishant’s expertise is in the application of quantitative models to problems in
Revenue Management, Supply Chain Management and competition modeling in
other situations.
Co-Supervisor: Prof. dr. René de Koster
Email: rkoster@rsm.nl
Website: http://www.rsm.nl/rdekoster
Bio: René (M.) B.M. de Koster is a Professor of Logistics and Operations
Management at Rotterdam School of Management, Erasmus University since
1995. He holds a PhD from Eindhoven University of Technology (1988). His
research interests are warehousing, material handling, supply chain
management, retail operations and reverse logistics. He is author / editor of 8
books and over 100 papers in books and academic journals. He is in the editorial
boards of 5 academic journals and fellow in two research schools. He is member
of the ELA R&D board, member or chairman of 3 national logistics awards, and
the chairman of Stichting Logistica.
List of recent publications and working papers:
N. Mishra and V. DeMiguel, “What Multistage Stochastic Programming Can Do
for Network Revenue Management”, under review, 2011.
N. Mishra and D. Li, “A comparison of Performance-based and
Transaction-based contracts in after-sales service supply chains”, RSM working
paper, 2011.
Chen, C.M., Gong, Y., Koster, M.B.M. de & Nunen, J.A.E.E. van (2010), “A
fexible evaluative framework for order picking systems”, Production and
Operations Management, 19(1), 70-82.
Quak, H.J. & Koster, René de (2009), “Delivering goods in urban areas. How to
deal with urban policy restrictions and the environment?”, Transportation
Science, 43(2), 211-227.
De Koster, M.B.M., Balk, B.M. (2008), “Benchmarking and monitoring
international warehouse operations in Europe”, Production and
Operations Management 17(2), 1-10.
Prof. Heugens & Dr. Wijen
School/Department:
Rotterdam School of Management
Department of Strategic Management and Entrepreneurship
Erasmus University Rotterdam
The Netherlands
Project Title:
The Effectiveness of Environmental Institutions in China
Abstract:
Requirements
candidate:
The impressive growth of economic activities in China has created important
environmental and policy challenges. Natural resources are rapidly becoming
depleted, which forces China to become an ever-greater importer of energy,
ores, and other resources. Furthermore, the pollution of land, water, and air
(including the emission of greenhouse gases) continues to increase,
threatening the livability of many major Chinese cities and industrial zones.
This raises important questions about the sustainability of ‘the Chinese
model’, not just from an environmental viewpoint, but also from the vantage
points of public health and business continuation.
It becomes increasingly clear that the current high rate of economic growth
may become unsustainable unless public and private governance
arrangements are put in place which enable business activities but constrain
their impact on the natural and social environment. The key question then is
what types of institutional arrangements are effective in addressing the
pressing environmental challenges that China presently faces, taking into
account and respecting the unique features of the Chinese model. Should the
central government play a leading role in securing natural resources and
containing pollution or leave it to local governments to accommodate local
conditions? Will the market clear natural resource scarcity? Can we expect
private companies to voluntarily assume environmental challenges, either on
an individual basis or through industry self-regulation? Is there a role for civil
society such as environmental organizations or community self-organization?
Should China adopt the practices that are effective in Europe and North
America, where environmental policies have been implemented for several
decades, or develop institutions that are germane to the Chinese situation?
And is the effectiveness of these types of institutions contingent on the nature
of the environmental issue at stake?
While the envisaged research includes theory development, the centre of
gravity will be with the collection and analysis of empirical data. Mixed
methods will be used to assess the actual performance of different institutions
in (selected parts of) China.
The extent to and way in which different environmental institutions are
effective in the Chinese business context is a topic that has received virtually
no attention in the academic literature, although it has become of major
societal importance. A dissertation shedding a clear light on the types of
institutional arrangements that effectively address environmental challenges
would, therefore, make sense from both an academic and a societal
perspective.
of Background: A solid background in management, sociology, or economics
(preferably in combination). Candidates with a background in environmental
studies may also be considered.
Master degree: Completed, preferably cum laude
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
GMAT (if applicable): 700 or higher
Other: Strong and demonstrable interest in pursuing a scientific career after
completing the PhD degree.
Supervisor information:
Prof. Dr. Pursey Heugens
Web: www.rsm.nl/pheugens
Email: pheugens@rsm.nl
Dr. Frank Wijen
Web: www.rsm.nl/fwijen
Email: fwijen@rsm.nl
Prof. Krug & Dr. Greeven
School/Department:
Rotterdam School of Management
Erasmus University Rotterdam
RSM Research Centre on China Business
http://www.erim.nl/chinabusiness
Project Title:
International Chinese entrepreneurship: strategic motives of Chinese
private enterprises
The rise of large developing economies such as China or India has
offered vast opportunities to challenge existing theories by empirically
testing available hypotheses and develop alternative models of
international strategy. The business context of developing economies is
substantially different from developed economies as for instance there
is an overlap between state and market institutions, dominance of
informal networks over formal legal structures and the capture of state
regulatory institutions by business elites. Acknowledging the contextual
nature of international strategy, it is likely that firms from developing
economies follow distinct internationalization strategies. The research
aims at substantiating theories on internationalization strategies adopted
by firms from developing economies.
Abstract:
In particular China draws the attention. In recent years, we witness a surge in
investment from China and the emergence of Chinese multinationals in
developing and developed economies. The past three decades of economic
prosperity have strengthened China’s international competitiveness and many
Chinese companies have seen either the limitations of the domestic market or the
attractions of foreign markets. A recent study by the IBM Institute for Business
Value and Fudan Globalization Survey indicates that, among others, the
acquisition of foreign technology and management skills is an important
motivation to enter foreign markets. Following a resource-based perspective,
foreign expansion then becomes a means to explore and exploit valuable
idiosyncratic resources, such as technological capabilities, brand names, or
management know-how.
This project will deal with questions such as: Which theories on
internationalization individually or in combination best explain current
internationalization patterns? What tools do theories give us to design
internationalization strategies for Chinese brands? What theoretical elements are
missing? To what extent do Chinese firms adapt their business model to the host
business environment? Which capabilities do Chinese firms have to develop to
successfully internationalize into developed economies?
Requirements
candidate:
of Background:
Strong English and Chinese language skills
A demonstrated interest in Chinese business and international strategy (e.g. course
work, scholarly papers but also professional experience) will certainly speak in
favor of the candidate.
Master degree: management, economics, political science
IELTS Grade: 7.0 (min. 6.0 per sub-score)
or
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information:
Prof. dr. Barbara Krug
bkrug@rsm.nl
http://www.erim.eur.nl/ERIM/Research/Centres/China_Business/Our_Centre/Core
_Members/Prof_Dr_Barbara_Krug?p_aff_id=150#axzz1V1NKu6RK

Krug, B. (2011). Public Finance. In Encyclopedia of Modern China: Charles
Scribner's Son.

Zhang, X., Reinmoeller, P. & Krug, B. (2010). Political Strategies:
Understanding How Foreign Multinational Companies Survive in China. In Tim
Goydke (Ed.), Corporate Culture in China and Japan. MV-Wissenschaft.

Krug, B. & Hendrischke, H. (2010). Market design in Chinese market
places. Asia Pacific Journal of Management.

Meuer, J., Di Vito, L. & Krug, B. (2010). Li Ning’s Grand Entrance? The
Global Emergence of Chinese Brands.

Krug, B. & Hendrischke, H. (2010). China's institutional architecture:
Interpreting the links between local governance and local enterprises. In U Vollmer
(Ed.), Institutionelle Ursachen des Wohlstands der Nationen (pp. 211-230). Berlin:
Duncker & Humblot.

Krug, B. & Hendrischke, H. (2010). China's institutional architecture: a new
institutional economics and organization theory perspective on the links between local
governance and local enterprises. Asia Pacific Journal of Management.

Krug, B. & Hendrischke, H. (2009). Smart Business Networks in Chinese
Characteristics. In P.H.M. Vervest, D.V. van Liere & L. Zheng (Eds.), The Network
Experience (pp. 179-189). Berlin: Springer.

Krug, B. & Hendrischke, H. (2009). Institution Building and Change in
China. Erim Report Series. onbekend: Rotterdam School of Management.

Zhu, Z. & Krug, B. (2009). Emerging Tax Regime: Local Tax Farming and
Central Tax Bureaucracy. Erim Report Series. onbekend: Rotterdam School of
Management.

Krug, B. (2008). Public finance in China since the late Qing Dynasty. Erim
Report Series. onbekend: Rotterdam School of Management.

Krug, B. & Betancourt, N.E. (2008). The effect of legal families on the
development of business law in China: who´s really writing the rules of the
game? Erim Report Series. onbekend: Rotterdam School of Management.

Krug, B. & Hendrischke, H. (2008). Framing China: Transformation and
Institutional Change through Co-evolution. Management and Organization Review,
4(1), 81-108.
Dr. Mark Greeven
mgreeven@rsm.nl
http://www.erim.eur.nl/ERIM/Research/Centres/China_Business/Our_Centre/Core
_Members/Ass_Prof_Mark_Greeven?p_aff_id=427#axzz1V1NKu6RK
Greeven, M.J. (2011) “New Asian Emperors: The Business Strategies of the Overseas
Chinese” by G. Haley, U. Haley, Journal of Organizational Change Management, Vol. 24
Iss: 3, pp.400 – 401 (book review)
Greeven, M.J. (2011) “Performance of the Chinese insurance industry under economic
reforms” by S. Yao, Z. Han, D. Luo in China Information, 25(1), pp. 108-110 (book
review)
Greeven, M.J., Munk, F. (2010) “Remade in China: Foreign Investors and Institutional
Change in China” by S. Wilson in Regional Studies, 44(8), pp. 1100-1101. (book
review)
Greeven, M.J. (2010) “Multinationals and emerging economies: The quest for
innovation and sustainability” by W. Dolfsma, G. Duysters and I. Costa in
Economische Statistische Berichten, ESB 4582. (book review)
Greeven, M.J., Yang, S., Heck, E., Krug, B. (2009) “The ecosystem of the Alibaba
Group: How is Alibaba Group’s strategy and implementation in China creating
sustainable value for suppliers, partners and customers?”, RSM Case Development
Centre.
Greeven, M.J. (2008) “The inside story of China’s High-Tech industry” by Yu Zhou in
Regional Studies, 42(10), pp. 1399 - 1399. (book review)
Zhao, X., Greeven, M.J. (2008) “Explorative case studies on technical, market and
institutional risks for entrepreneurs in China’s emerging knowledge industries:
Hangzhou’s software business”, Keyan Guanli [Chinese journal - Science Research
Management], Vol. 29, Special Issue, pp. 1-6.
Greeven, M.J., Zhao, X. (2008) "Innovation, competences and the role of knowledge
networks in Hangzhou's software industry", in P. H. M. Vervest, D. W. van Liere & L.
Zheng (Eds.), The Network Experience, Berlin. Germany: Springer, Chapter 13.
Greeven, M.J. (2007) “The new great leap: The rise of China’s ICT industry”, in
Barbara Krug and Hans Hendrischke (eds) China’s Economy in the 21st century:
Enterprise and business behaviour, London: Edward Elgar, Chapter 4.
Baaij, M.G., Greeven, M.J., Van Dalen, J. (2004) “Persistent Superior Economic
Performance, Sustainable Competitive Advantage, and Schumpeterian Innovation: The
Case of the Leading Established Computer Firms, 1954-2002”, European
Management Journal, Vol.22, No. 5., pp. 517-531
Prof. Rene de Koster & Prof Harry Geerlings
School/Department:
Rotterdam School of Management / Erasmus School of Social Sciences
Erasmus University Rotterdam
The Netherlands
Project Title:
Abstract:
Eco- efficient facilities
Requirements
candidate:
As a consequence of the increased attention for sustainability, companies try to
‘green’ their production and distribution facilities. Green facilities emit less
greenhouse gasses, use recycled construction materials, do not pollute water,
generate their own energy, and are located such that inbound and outbound
transportation can occur in a sustainable manner. This has a major impact on the
construction and design as well as on the internal processes; material handling
systems should consume less energy and packaging materials have are reused.
Although various methods exist to evaluate the sustainability score of industrial
facilities (LEED, Breeam), they do not take into account design alternatives. This
research aims to answer the following questions:
1) is it possible to develop an unambiguous scoring method for sustainable
buildings and operations? We focus in particular on warehouse and terminal
operations
2) Are green warehouses competitive (in logistics performance, operations, work
environment, quality, and costs)?
of Background: Quantitative methods, in particular operations research, Master:
Mathematics, Econometrics, (Industrial) Engineering, or Computer science
Master degree: Yes
IELTS Grade: 7.5 or higher for all parts
or
TOEFL Score: 100 or higher (min. 20 per sub-score)
GMAT: 650
GRE: Verbal – 580, Quantitative – 740, Analytical – 5.0
See
also:
http://www.erim.eur.nl/ERIM/Doctoral_Programme/PhD_in_Management/How_t
o_Apply/Frequently_Asked_Questions
Supervisor
information:
Supervisor: Prof. dr. M.B.M. de Koster, http://www.rsm.nl/rdekoster
E-mail: rkoster@rsm.nl
Co-Supervisor: Prof. dr. H. Geerlings
Prof. Rene de Koster & Prof. Rommert Dekker
School/Department:
Rotterdam School of Management / Erasmus School of Economics
Erasmus University Rotterdam
The Netherlands
Project Title:
Efficient management of container terminal transport and storage processes
Abstract:
In many countries container terminal operations have become more and more
automated. To load and unload containers from ships, twin-load cranes are
available, containers are moved between the storage stack and the quay by
automated guided vehicles, that sometimes can even stack containers. Specialized
rail-mounted stacking cranes store and retrieve the containers from the stack and
bring them to land-side or sea-side drop off points. The performance of these
terminals, in particular the makespan needed to unload and load a complete ship,
train or truck is determined for a large part by the design and operating algorithms
of the terminal. This research aims to investigate algorithms for scheduling loads
and controlling the different vehicle types and to determine stacking algorithms to
handle containers efficiently at such automated terminals.
Requirements
candidate:
of Background: Quantitative methods, in particular operations research, Master:
Mathematics, Econometrics, (Industrial) Engineering, or Computer science
Master degree: Yes
IELTS Grade: 7.5 or higher for all parts
or
TOEFL Score: 100 or higher (min. 20 per sub-score)
GMAT: 650
GRE: Verbal – 580, Quantitative – 740, Analytical – 5.0
See
also:
http://www.erim.eur.nl/ERIM/Doctoral_Programme/PhD_in_Management/How_t
o_Apply/Frequently_Asked_Questions
Supervisor
information:
Supervisor: Prof.dr. M.B.M. de Koster, http://www.rsm.nl/rdekoster
E-mail: rkoster@rsm.nl
Co-Supervisor: Prof.dr.ir. R. Dekker, http://www.few.eur.nl/people/rdekker
List of recent publications:
Stahlbock, R. and S. Voss (2008). "Operations research at container terminals: a
literature update." OR Spectrum 30(1): 1-52.
Vis, I. F. A., de Koster, R. M. B., & Savelsbergh, M. W. P. (2005). Minimum
vehicle fleet size under time-window constraints at a container terminal.
Transportation Science, 39(2), 249-260.
Vis, I. F. A., R. de Koster, K. J. Roodbergen and L. W. P. Peeters (2001).
"Determination of the number of automated guided vehicles required at a
semi-automated container terminal." Journal of the Operational Research
Society 52(4): 409-417.
Vis, I.F.A., and Roodbergen, K.J. (2009), Scheduling of container storage and
retrieval, Operations Research 57(2), 456-467
Borgman, B., van Asperen, E. and Dekker, R., (2010), Online Rules for Container
Stacking, OR Spectrum, 32(3), p.687-716.
Prof. Rob Zuidwijk
School/Department:
Rotterdam School of Management
Erasmus University of Rotterdam
The Netherlands
Project Title:
Abstract:
Drivers for Green Port Related Operations
There is a need to reduce emissions caused by port related logistics. The
interplay between the drivers and scopes of individual supply chains,
international transportation networks, and port clusters, is important here. We
seek research proposals that address one of the following topics:

The measurement of environmental impacts and internalization of the
associated costs in order to create drivers for green innovations;

Role of supply chain coordination in footprint reduction; incentive schemes
under voluntary emission reduction programs;

Stakeholder analysis about the legislative and regulatory processes for
emission reduction in ports and port networks, i.e. container related and/or
port management related and/or global trade patterns related;

Comparative analysis on governmental innovation and port management
with respect to climate change effects and climate change effects adaption.
Requirements
candidate:
of Background: Econometrics, Operations Research, Industrial Engineering, or
comparable degree with a substantial affiliation with quantitative modeling.
We search a candidate who wants to use his/her analytical skills to analyze the
aforementioned issues in supply chains. The candidate should be inspired by
and be comfortable with a working environment in which real-life business
cases are being explored and where quantitative and formal models are being
developed based on these cases. We consider some experience with developing
and applying quantitative models to real-life cases as a valuable asset.
Master degree: Yes
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
or
TOEFL Score: 100 or higher (min. 20 per sub-score)
GMAT/GRE: 85% or higher
See also: www.erim.nl
Supervisor
information:
Prof. dr. Rob A. Zuidwijk
www.rsm.nl/rzuidwijk
rzuidwijk@rsm.nl
The supervisor mentioned here is Academic Director of Erasmus Smart Ports
(ESPR); see www.erim.eur.nl/ERIM/Research/Centres/Smart_Port.
Based on the topic of the approved proposal, one of the port professors of ESPR
will be involved as well.
Recent publication list
Jos van Hillegersberg, Jimmy Tseng, Rob Zuidwijk, Jo van Nunen (2006). Hub
to Higher Performance? An Internet Hub for the Vos Logistics Supply Chain.
International Journal of Advanced Manufacturing Systems 9(1): 13-23.
Leo Kroon, Rob Zuidwijk (2006). Mathematical models for planning support,
pp. 245-277 in: Wout van Wezel, Rene Jorna, Alexander Meystel (eds.).
Planning in Intelligent Systems, Wiley Interscience.
Rob Zuidwijk and Harold Krikke (2008). Strategic response to EEE returns:
Product eco-design or new recovery processes? European Journal of
Operational Research 191: 1206–1222.
Muhammad Jalil, Rob Zuidwijk, Harold Krikke (2008). Yesterday proactive,
responsive today: Use of Information to enhance planning in closed loop supply
chains, pp. 215-234 in: Surendra Gupta, Fred Lamberts (eds.). Environment
Conscious Manufacturing. CRC Press.
F. Jordan Srour and Rob Zuidwijk (2008). How Much is Location Information
Worth? A Competitive Analysis of the Online Traveling Salesman Problem with
Two Disclosure Dates. ERIM Research Paper ERS-2008-075-LIS, Erasmus
University Rotterdam.
Tamás Máhr, Jordan Srour, Mathijs de Weerdt, Rob Zuidwijk (2009). The merit
of agents in freight transport, pp. 332-341 in: Ana L.C. Bazan, Franziska Blügl
(eds.). Multi-Agent Systems for Traffic and Transportation Engineering,
Information Science Reference.
Michael Ketzenberg, Rob Zuidwijk (2009). Optimal Pricing, Ordering, and
Return Policies for Consumer Goods. Production and Operations Management
18(2): 344-360.
Erik Giesen, Wolf Ketter, Rob Zuidwijk (2009a). An Agent-based Analysis
Approach to Resource Allocation in the Dutch Youth Health Care System. In
Proceedings of the Nineteenth Workshop on Information Systems and
Technology (WITS-09). Phoenix, Arizona, USA.
Erik Giesen, Wolf Ketter, Rob Zuidwijk (2009b). An Agent-based Approach to
Improving Resource Allocation in the Dutch Youth Health Care Sector. In
Proceedings of the European Conference on Information Systems (ECIS) (pp.
2403-2415). Verona, Italy.
Tamas Mahr, Jordan Srour, Mathijs M. de Weerdt, and Rob Zuidwijk (2010).
Can agents measure up? A comparative study of an agent-based and on-line
optimization approach for a drayage problem with uncertainty. Transportation
Research: Part C 18(1): 99–119.
Rob Zuidwijk and Albert Veenstra (2010). The Value of Information in
Container Transport: Leveraging the Triple Bottom Line. ERIM Research Paper
ERS-2010-039-LIS, Erasmus University Rotterdam.
Ran Li, Albert Veenstra, Ming Yu, Lei Zhao, Rob Zuidwijk (2010). Information
Exchange in Global Logistics Chains. Service Operations and Logistics and
Informatics (SOLI), 2010 IEEE International Conference on , pp.264-269,
15-17 July 2010. doi: 10.1109/SOLI.2010.5551570
Rommert Dekker, Cerag Pince, Rob Zuidwijk, Muhammed Jalil (2010). On the
use of installed base information for spare parts logistics: a review of ideas and
industry practice. Submitted to International Journal of Production Economics.
Muhammad Jalil, Rob Zuidwijk, Moritz Fleischmann, Jo van Nunen (2011).
Spare Parts Logistics and Installed Base Information. Journal of the Operational
Research Society 62(3): 442-457.
Muhammad Jalil, Rob Zuidwijk, Moritz Fleischmann, Jo van Nunen (2011).
Revenue Management and Spare Parts Logistics Execution. Submitted to
European Journal of Operational Research.
Prof. Van den Ende & Dr. Rijsdijk 1
School/Department:
Rotterdam School of Management
Department of Management of Technology and Innovation
Erasmus University Rotterdam
The Netherlands
Project Title:
Control in outsourced innovation projects: The effects of setting
goals, prescribing rules, and making friends
Abstract:
As firms increasingly outsource product innovation, a fundamental issue
facing these firms is how to exercise adequate control over such projects
conducted by suppliers. Client firms may use process controls that clearly
specify the appropriate behaviors and processes in which a supplier must
engage (prescribing rules), clients may apply outcome controls by setting
goals, or control an outsourced project in an informal manner (by making
friends). Control is important, because it structures and directs innovation
processes and increases the chance that projects remain aligned with the client
firms’ interests.
This research project aims to investigate the idea that the three main
control mechanisms each manage knowledge in a unique way and
therefore have unique consequences. Based on recent theoretical
developments, it can be hypothesized that control
by setting goals leads to innovative products, control by
prescribing rules leads to predictable outcomes, and marking friends
results in flexibility within innovation projects. Investigating these
effects is important as it is not about controls themselves but the way
in which they relate to the essence of product innovation: the
generation and application of new knowledge.
PhD will investigate the relationships of interest through
experimental designs and field surveys. The experimental designs
will enable a direct observation of the flow of knowledge, which is
unfeasible in field settings. Experimental findings will subsequently
be validated through field surveys. One objective of this project is to
compare Western and Chinese survey data. Within the Chinese
context, the building of personal relations and trust (guanxi) might be
more important than in Western countries. At the same time,
however, research has shown that formal controls are becoming
increasingly important for Chinese firms involved in outsourcing
alliances. As such, the roles of the different control mechanisms and
how they affect innovation outsourcing outcomes in Western and
Chinese contexts remains unclear. This research will therefore help
Western and Chinese firms and their managers better understand how
outsourced product innovation should be organized.
Requirements
candidate:
of Master degree: Master in Business Administration, Psychology, Economy,
Supervisor information:
Technology, or equivalent
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
GMAT: 680 or higher
Other: In addition to these formal requirements, candidates for the Program
are selected on the basis of their CVs, academic references, and interview(s)
with the potential supervisor(s)
Main supervisor:
Prof.dr. Jan van den Ende
Professor of Management of Technology and Innovation
Email: jende@rsm.nl
Website: http://www.rsm.nl/jvandenende
Co-supervisor:
Dr. Serge A. Rijsdijk
Assistant professor of Innovation Management
Email: srijsdijk@rsm.nl
Website: www.rsm.nl/srijsdijk
List of recent publications:
1.
Rijsdijk, S.A. & Ende, J.C.M. van den (2011). Control combinations
in new product development projects. The Journal of Product
Innovation Management, 28(6).
2.
Jaspers, F.P.H., Prencipe, A. & Ende, J.C.M. van den (2011).
Organizing Inter-Industry Architectural Innovations: Evidence from
Mobile Communication Applications. Accepted for publication. The
Journal of Product Innovation Management, Accepted.
3.
Rijsdijk, S.A., Langerak, F. & Hultink, E.J. (2011). Understanding a
Two-Sided Coin: Antecedents and Consequences of a Decomposed
Product Advantage. The Journal of Product Innovation Management,
28(1), 33-47.
4.
Rauch, A & Rijsdijk, S.A. (2011). The Effects of General and
Specific Human Capital on Long-term Growth and Failure of Newly
Founded Businesses, Entrepreneurship Theory and Practice
(forthcoming).
5.
Kijkuit, B. & Ende, J.C.M. van den (2010). With a Little Help from
Our Colleagues: A Longitudinal Study of Social Networks for
Innovation. Organization Studies, 31(4), 451-479.
6.
Jaspers, F.P.H. & Ende, J.C.M. van den (2010). Open innovation and
systems integration. How and why firms know more than they
make. International Journal of Technology Management, (52 (3/4)),
275-294.
7.
Blindenbach-Driessen, F.P., Dalen, J. van & Ende, J.C.M. van den
(2010).Subjective Performance Assessment of Innovation
Projects. The Journal of Product Innovation Management, 27(4),
572-592.
8.
Blindenbach-Driessen, F. & Ende, J.C.M. van den (2010). Innovation
management practices compared: The example of product-based
firms. The Journal of Product Innovation Management, 27(5),
705-724.
9.
Wagener, S.L., Gorgievski, M.J. & Rijsdijk, S.A.
(2010). Businessman or host? Individual differences between
entrepreneurs and small business owners in the hospitality
industry. Service Industries Journal, 30(9-10), 1513-1527.
10. Ende, J.C.M. van den & Kijkuit, B. (2009). Nurturing good
ideas. Harvard Business Review, 87(4), 24-24.
11. Rijsdijk, S.A. & Hultink, E.J. (2009). How Today's Consumers
Perceive Tomorrow's Smart Products. The Journal of Product
Innovation Management, 26(1), 24-42.
12. Langerak, F., Rijsdijk, S.A. & Dittrich, K. (2009). Development Time
and New Product Sales: A Contingency Analysis of Product
Innovativeness and Price. Marketing Letters, 20(4), 399-413.
13. Ende, J.C.M. van den, Jaspers, F.P.H. & Gerwin, D.
(2008). Involvement of system firms in the development of
complementary products. The influence of novelty. Technovation,
28(11), 726-738.
14. Rijsdijk, S.A., Hultink, E.J. & Diamantopoulos, A. (2007). Product
Intelligence: Its Conceptualization, Measurement and Impact on
Consumer Satisfaction. Journal of the Academy of Marketing
Science, 35(3), 340-356.
15. Kijkuit, B. & Ende, J.C.M. van den (2007). The Organizational Life
of an Idea. Integrating Social Network, Creativity and
Decision-Making Perspectives. Journal of Management Studies,
44(6), 863-882.
Prof. Van den Ende & Dr. Rijsdijk 2
School/Department:
Rotterdam School of Management
Erasmus University Rotterdam
The Netherlands
Project Title:
Step by step, in parallel, or flexible? Conditional effects of
innovation project organization on outcomes
Abstract:
The literature distinguishes three models for sequencing innovation
tasks (in product or service development): sequential, parallel and
flexible models. Authors argue have different arguments for how
managers should choose between these models. Some authors claim
that stable environments require a sequential or parallel model,
whereas uncertain environments demand a flexible process. In such a
flexible process, different activities are performed in both a
simultaneous and iterative manner, which increases responsiveness
and performance. However, other authors claim that under high
uncertainty the simultaneous conduction of activities leads to
excessive communication costs.
This PhD project investigates the choice between alternative models
for the organization of innovation projects from a knowledge
perspective. In particular, the PhD will investigate potential
contingencies that affect the choice between different models and
how they affect project performance. One of these contingencies may
be the depth and breadth of the knowledge used in the project, but
also strategic imperatives (such as required speed) and environmental
turbulence will be investigated. Case studies, a survey and
(laboratory) experiments can be performed. For the empirical field
setting a choice will be made between industries (fast moving
consumers goods, electronics, services, etc.)
Requirements
candidate:
of Master degree: Master in Business Administration, Sociology, Economy,
Supervisor information:
Technology, or equivalent
IELTS Grade: 7.5 or higher (min. 6.0 per sub-score)
GMAT: 680 or higher
Other: In addition to these formal requirements, candidates for the Program
are selected on the basis of their CVs, academic references, and interview(s)
with the potential supervisor(s)
Main supervisor:
Prof.dr. Jan van den Ende
Professor of Management of Technology and Innovation
Email: jende@rsm.nl
Website: http://www.rsm.nl/jvandenende
Co-supervisor:
Dr. Serge A. Rijsdijk
Assistant professor of Innovation Management
Email: srijsdijk@rsm.nl
Website: www.rsm.nl/srijsdijk
List of recent publications:
16. Rijsdijk, S.A. & Ende, J.C.M. van den (2011). Control combinations
in new product development projects. The Journal of Product
Innovation Management, 28(6).
17. Jaspers, F.P.H., Prencipe, A. & Ende, J.C.M. van den (2011).
Organizing Inter-Industry Architectural Innovations: Evidence from
Mobile Communication Applications. Accepted for publication. The
Journal of Product Innovation Management, Accepted.
18. Rijsdijk, S.A., Langerak, F. & Hultink, E.J. (2011). Understanding a
Two-Sided Coin: Antecedents and Consequences of a Decomposed
Product Advantage. The Journal of Product Innovation Management,
28(1), 33-47.
19. Rauch, A & Rijsdijk, S.A. (2011). The Effects of General and
Specific Human Capital on Long-term Growth and Failure of Newly
Founded Businesses, Entrepreneurship Theory and Practice
(forthcoming).
20. Kijkuit, B. & Ende, J.C.M. van den (2010). With a Little Help from
Our Colleagues: A Longitudinal Study of Social Networks for
Innovation.Organization Studies, 31(4), 451-479.
21. Jaspers, F.P.H. & Ende, J.C.M. van den (2010). Open innovation and
systems integration. How and why firms know more than they
make. International Journal of Technology Management, (52 (3/4)),
275-294.
22. Blindenbach-Driessen, F.P., Dalen, J. van & Ende, J.C.M. van den
(2010).Subjective Performance Assessment of Innovation
Projects. The Journal of Product Innovation Management, 27(4),
572-592.
23. Blindenbach-Driessen, F. & Ende, J.C.M. van den (2010). Innovation
management practices compared: The example of product-based
firms. The Journal of Product Innovation Management, 27(5),
705-724.
24. Wagener, S.L., Gorgievski, M.J. & Rijsdijk, S.A.
(2010). Businessman or host? Individual differences between
entrepreneurs and small business owners in the hospitality
industry. Service Industries Journal, 30(9-10), 1513-1527.
25. Ende, J.C.M. van den & Kijkuit, B. (2009). Nurturing good
ideas. Harvard Business Review, 87(4), 24-24.
26. Rijsdijk, S.A. & Hultink, E.J. (2009). How Today's Consumers
Perceive Tomorrow's Smart Products. The Journal of Product
Innovation Management, 26(1), 24-42.
27. Langerak, F., Rijsdijk, S.A. & Dittrich, K. (2009). Development Time
and New Product Sales: A Contingency Analysis of Product
Innovativeness and Price. Marketing Letters, 20(4), 399-413.
28. Ende, J.C.M. van den, Jaspers, F.P.H. & Gerwin, D.
(2008). Involvement of system firms in the development of
complementary products. The influence of novelty. Technovation,
28(11), 726-738.
29. Rijsdijk, S.A., Hultink, E.J. & Diamantopoulos, A. (2007). Product
Intelligence: Its Conceptualization, Measurement and Impact on
Consumer Satisfaction. Journal of the Academy of Marketing
Science, 35(3), 340-356.
30. Kijkuit, B. & Ende, J.C.M. van den (2007). The Organizational Life
of an Idea. Integrating Social Network, Creativity and
Decision-Making Perspectives. Journal of Management Studies,
44(6), 863-882.
Faculty of Social Sciences
Dr. Willem Schinkel
School/Dep
artment:
Project Title:
Abstract:
Erasmus University Rotterdam Faculty of Social Sciences
Department of Sociology
The Netherlands
Citizenship differentiation and access to education
In recent decades, citizenship has emerged as a major theme both in social
science and in policy making. Over against nation-state citizenship in a political
and legal sense, various forms of social citizenship have been scrutinized. This
project focuses on the struggles arising out of what can be called the
differentiation of citizenship. Citizenship has become more diverse, fragmented
and volatile. Citizenship statuses can be multiple instead of unitary and
changing instead of rigid. On the one hand, this jeopardizes rights and living
standards, but on the other hand, forms of ‘flexible citizenship’ can selectively
benefit individuals or groups. This can lead to struggles that are the focus of this
project.
The project investigates Chinese experiences with floating populations,
most notably migrants with citizenship statuses that can be considered
‘transnational’ and irregular migrants. The Chinese case is an interesting
comparison both because of the size of floating populations (with over 100
million rural migrant population, pejoratively referred to as mingong) and
because of their diverse characteristics but overall inclusion within one and the
same national context. Previous research has often focused on migrants crossing
national borders (often involving western borders), but the case of China makes
us sensitive to the ways intra-national factors play a role in the dynamics of
citizenship differentiation. Specifically, regimes of governing and scaled market
access are important here. In terms of regimes of governing, the hukou system,
with its strong citizenship differentiation along rural/urban lines, is interesting
here. When rural migrants move to the city or when urbanization uproots rural
populations and renders them floating, shifts in citizenship status occur that are
the process of formal regulations but also of the ways in which these are
negotiated in practice. This leads to conflict for instance in the spheres of
education, health care and housing.
The project specifically focuses on struggles over access to education.
Taking Shanghai as main research site, it charts and analyzes social conflict
arising out of citizenship differentiation. Education is a crucial site at which
such struggles unfold, as it is a key factor in the (intergenerational) social
mobility of floating populations. In a first phase, this project identifies the types
of struggle over access to education. In a second phase, it selects strategic cases
which it investigates through document analysis, discourse analysis, interviews
and, where possible, brief stints of ethnographic research in the form of
Marcus’s multi-sited ethnography.
Requirement Background: sociology, anthropology, ethnography
s
of Master degree: yes
IELTS Grade: 7 (min. 6.0 per sub-score) Or
candidate:
TOEFL: 100 (min. 20 per sub-score)
Methodological requirements: document analysis, ethnographic methods.
Personal
website
(including
Supervisor
information: http://www.eur.nl/fsw/research/cimic/
email
address):
Dr. Willem Schinkel E-mail: Schinkel@fsw.eur.nl
Recent publication list (preferably last 3-5 years)
International books:
Schinkel, W. & L. Noordegraaf-Eelens (2011): In Medias Res. Peter Sloterdijk’s
Spherological Poetics of Being. Amsterdam: Amsterdam University Press.
Schinkel, W. (2010): Aspects of Violence. A Critical Theory. Basingstoke: Palgrave
Macmillan.
Schinkel, W. (ed.) (2009): Globalization & the State: Sociological Perspectives on the State
of the State. Basingstoke: Palgrave Macmillan.
Prof. Dr. J.P.L. Burgers.
School/Department: Erasmus University Rotterdam
Faculty of Social Sciences
Department of Sociology
Research Group ‘Citizenship, Migration and the City’ (CIMIC)
The Netherlands
Project Title:
Abstract:
Migration, Urban Labor Markets and Social Mobility
Since the 1980s much research has been done on the effects of the
internationalization of the economy on urban labor markets. Two topics
are central in this respect. First, structural changes of the labor market as
a result of a globalizing economy. More in particular, the main research
question has been whether urban labor markets are polarizing (a growth
of the number of jobs both at the top and the bottom of the labor market)
or upgrading (an increase of jobs at the higher end of the labor market
and a decrease at the lower end). Secondly, much attention has been paid
to the position of the (increasing number of) migrants in urban labor
markets. Although a growing number of them can be found in
professional jobs (ex-pats!), most of them are engaged in low-skilled
work in the manufacturing industries, construction and commercial
services.
Although the position of migrants in urban labor markets has received
ample attention, arguably one of the most important aspirations of most
migrants - getting ahead, creating a better life for their offspring - has not
generated much interest in studies focusing on urban labor market
structures. Most of these studies are static in the sense that although they
focus on structural changes of job structures and look at where migrants
are employed, they seldom address actual social mobility of migrants.
Upward or downward mobility has mostly been researched in the field of
housing studies, especially in those focusing on residential mobility.
This hiatus in our knowledge of urban labor markets is theoretically
interesting and of great importance in terms of social policy in big cities
in China. The last census has shown that the number of migrants in those
cities is substantial (more than 30% of the population of Greater
Shanghai). These migrants are employed in the sectors mentioned before:
manufacturing, construction, personal and commercial services.
Manufacturing in Chinese cities is already upgrading, so that eventually
the demand for low-skilled labor will decrease. Services are
characterized by a polarized job structure, so in this sector a great number
of low-skilled jobs will remain. But as China’s population will
increasingly be highly skilled and second generation migrants will want
to do better than their parents, the problem might be a shortage of jobs at
the professional level.
This research will focus on the mobility in urban labor markets in
selected Chinese cities. After an analysis of the changing structure of
urban labor markets, the research will focus on labor market aspirations
and mobility of selected urban groups, more in particular
second-generation migrants and highly skilled young adults.
Requirements
candidate:
Supervisor
information:
of Background: urban studies, sociology, social or human geography,
anthropology.
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Methodological requirements: multivariate statistics
Supervisor: Prof. Dr. J.P.L. Burgers
E-mail: burgers@fsw.eur.nl
Personal
website:
http://www.eur.nl/fsw/soc/medewerkers/profielen/profiel_metis/1006318/
Website CIMIC: http://www.eur.nl/fsw/research/cimic/
List of recent publications:
Waal, J. van der & Burgers, J.P.L. (2011). Post-Industrialization, job
opportunities and ethnocentrism. A comparison of 22 Dutch Urban
Economies. Urban Studies, 48(4), 681-697.
Schaake, K., Burgers, J.P.L. & Mulder, C.H. (2010). Ethnicity at the
individual and neighborhood level as an explanation for moving out of
the neighborhood. Population Research and Policy Review, 29(4),
593-608.
Bochove, M.E. van & Burgers, J.P.L. (2010). Disciplining the Drifter:
The Domestication of Travellers in the Netherlands. British Journal of
Criminology, 50(3), 206-221.
Waal, J. van der & Burgers, J.P.L. (2009). Post-Industrialization and
Ethnocentrism in Contemporary Dutch Cities. The Effects of Urban Job
Opportunities and Spatial Segregation. In J.W. Duyvendak, F Hendriks &
M Van Niekerk (Eds.), City in Sight. Dutch Dealings with Urban
Change (pp. 25-40). Amsterdam: Amsterdam University Press.
Burgers, J.P.L. (2009). Changing Society by Rebuilding
Neighbourhoods: On the Effects of Restructurering Deprived Urban
Areas. Experiences from the Netherlands. In Katrien de Boyser & et.al
(Eds.), Between the Social and the Spatial. Exploring the Multiple
Dimensions of Poverty and Social Exclusion (pp. 133-149). Farnham:
Ashgate.
Waal, J. van der & Burgers, J.P.L. (2009). Unravelling The Global City
Debate on Social Inequality: A Firm Level Analysis of Wage Inequality
in Amsterdam and Rotterdam. Urban Studies, 46(13), 2715-2729.
Burgers, J.P.L. & Waal, J. van der (2008). Globalizing Urban Economies
and Social Inequality: an Empirical Assessment: The Case of Amsterdam
and Rotterdam. In P. Ache, H.T. Andersen, T. Maloutas, M. Raco & T.
Tasan-Kok (Eds.), Cities Between Competitiveness and Cohesion:
Discourses, Realities and Implementation (pp. 79-97). Springer.
Burgers, J.P.L. & Vranken, J. (2008). Réussir un programme de
développement urbain. Expériences issues de neuf pays européens.
Guide pour l'action. Paris: Les Éditions de la DIV.
Snel, E., Burgers, J.P.L. & Leerkes, A.S. (2007). Class Position of
Immigrant Workers in a Post-Industrial Economy: The Dutch Case.
Journal of Ethnic and Migration Studies, 33(8), 1323-1343.
Burgers, J.P.L. (2006). Local consequences of globalisation: urban
inequality and the fragmentation of cities. In A.F. Koekoek, J.M. van der
Hammen, T.A. Velema & M. Verbeet (Eds.), Cities and globalisation.
Exploring new connections (Netherlands Geographical Studies) (pp.
22-34). Utrecht: Koninklijk Nederlands Aardrijkskundig Genootschap.
Burgers, J.P.L. & Lugt, H. van der (2006). Spatial assimilation of
minority groups. Netherlands Journal of Housing and the Built
Environment, 21, 127-139.
Prof. Godfried Engbersen 1
School/Department:
Erasmus University Rotterdam Faculty of Social Sciences
Department of Sociology
Research Group ‘Citizenship, Migration and the City’ (CIMIC)
The Netherlands
Project Title:
Residence status and crime among first- and second-generation ‘floating
migrants’ in China
Abstract:
There is an extensive American and European social science literature on
international migration and crime. A new insight in this literature is that
crime patterns among immigrants can to some extent be understood as a
response to the consequences of residence status. This is most clear in the
case of undocumented immigrants, who have an interest in evading police
contacts in order to reduce the risk on immigration detention and
deportation. At the same time, undocumented migrants are legally excluded
from (parts of) the labour market, from housing opportunities, and from
education. Such policies of social exclusion may lead to subsistence crime
via the strain mechanism, as they complicate the realization of certain
culturally prescribed goals.
Although levels of international immigration are relatively low in China, its
cities are populated by large numbers of domestic migrants who originate
from rural environments. As a result of the Hukou system, these ‘floating’
migrants, and their offspring, have limited social rights, and ‘floating
status’ is likely to reduce opportunities for upward social mobility. Yet, a
growing number of domestic migrants do not return to the countryside, but
settle in the cities and have families. Their children in particular, may feel
they are entitled to high urban status, which, however, may be unreachable
for most. Resulting relative deprivation and feelings of unfairness may
foster crime and rebellion.
This research project will map the crime patterns among first- and
second-generation domestic migrants with floating status by focusing on a
Chinese city or a typical migrant neighborhood within such a city. In a
second phase the researcher will conduct in-depth interviews to examine
whether these patterns can be explained from the social position of these
migrants in general and from the real and perceived consequences of the
Houku system in particular.
Requirements
candidate:
Supervisor
information:
of
Background: Political or Social Sciences (including Criminology,
Migration Studies, Sociology, Social or Human Geography)
Master degree: Yes
IELTS Grade: 7 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Methodological requirements: multivariate statistics and ethnographic
research
Supervisor: Prof. Godfried Engbersen Engbersen@fsw.eur.nl
Co-supervisor: Prof. Arjen Leerkes
Personal website:
http://www.eur.nl/fsw/staff/homepages/engbersen/
Website CIMIC:
http://www.eur.nl/fsw/research/cimic/
List of recent publications:
Leerkes, A., M. Leach and J. Bachmeier (in press), ‘Borders Behind the
Border. An Exploration of State-level Differences in Migration Control and
their Effects on U.S. Migration Patterns’, Journal of Ethnic and Migration
Studies.
Leerkes, A., G. Engbersen and J. van der Leun (in press), ‘Crime among
irregular migrants and the influence of internal border control’, Crime, Law
and Social Change.
Leerkes, A., and Kulu, I. (2011), ‘Playing hard(er) to get? The State,
International Couples, and the Income Requirement’. European Journal
of Migration and Law 13 (1): 95-121.
Leerkes, A. and D. Broeders (2010), ‘A question of mixed motives? Formal
and informal functions of administrative immigration detention’, British
Journal of Criminology 50 (5): 830-850.
Black, Richard, Godfried Engbersen, Marek Okólski & Cristina Panţîru
(eds.) (2010) A Continent Moving West? EU Enlargement and Labour
Migration from Central and Eastern Europe, Amsterdam: Amsterdam
University Press
Broeders. Dennis and Godfried Engbersen (2007). ‘The Fight against
illegal Migration’. Identification Policies and Immigrants’ Counter
Strategies. American Behavioral Scientist, 50 (12): 1592-1609
Engbersen, G. and Leerkes, A. (2009) ‘Toward a Smarter and More Just
Fortress Europe’, in: Frost, N., Freilich, J. and Clear, T. (Eds.)
Contemporary Issues in Criminal Justice Policy, 1st Edition. Belmont:
Wadsworth Pub Co. Pp. 211-220
Leerkes, A. (2009) Illegal Residence and Public Safety in the Netherlands.
Amsterdam: Amsterdam University Press.
Leerkes, A., G. Engbersen and M. van San (2007) ‘Shadow Places. Patterns
of Spatial Concentration and Incorporation of Irregular Immigrants in the
Netherlands’, Urban Studies, 44 (8), pp. 1491-1516.
Snel, E., G. Engbersen and A. Leerkes (2006), ‘Transnational Involvement
and Social Integration’, Global Networks 6 (3): 285-308.
Engbersen, G., M. Van San and A. Leerkes (2006), ‘A Room with a View.
Illegal Immigrants in the Legal Capital of the World’, Ethnography 7:
209-242.
Prof. Godfried Engbersen 2
School/Department:
Erasmus University Rotterdam
Faculty of Social Sciences
Department of Sociology
Research Group ‘Citizenship, Migration and the City’ (CIMIC)
The Netherlands
Project Title:
Floating populations: fourfold labor migration and integration
Abstract:
This proposal is about the social consequences of internal labor migration
within the People’s Republic of China. China is facing substantial internal
migration from the rural areas to the big cities. These internal labor
migration resemble four basic patterns of labor migration that are also
visible within the enlarged European Union (EU): (1) temporary, circular
migration (migrants travelling back and forth) (2) bi-local migration; labor
migrants remaining for long periods in a city, but retain strong links to their
home town (and finally return); (3) settlement migration: migrants who
settle permanently in the destination city and (4) footloose migration:
migrants who have weak ties with the destination city and with their home
town.
These different patterns of labor migration give rise to different patterns of
integration in the city: some migrants become well integrated and receive
Hukou, while others are semi-integrated in cities or lead a marginal
existence. Insight into the nature of labor migrants is crucial to analyze the
social consequences of floating populations for cities. Do temporary
migrants turn into settlement migrants? And under what circumstances do
migrants return to their home town or migrate to other destination cities?
This research project aims to analyze contemporary patterns of labor
migration from rural areas and towns to Shanghai. It is based on census
data and on local surveys with labor migrants in the city of Shanghai. A
second aim of this project is to compare these patterns of labor migration
within China with the contemporary labor migration patterns within the
enlarged Europe Union (especially from Central and Eastern Europe to
Western Europe) and to compare also the policy dilemmas (especially
housing) and social problems (tensions between floating and established
populations) that stem from it.
Requirements
candidate:
Supervisor
information:
of
Background: Political or Social Sciences (including Migration Studies,
Sociology, Social or Human Geography)
Master degree: Political or Social Sciences
IELTS Grade: 7 (min. 6.0 per sub-score) Or
TOEFL: 100 (min. 20 per sub-score)
Methodological requirements: multivariate statistics and qualitative
interviewing
Supervisor: Prof. Godfried Engbersen E-mail: Engbersen@fsw.eur.nl
Personal website: http://www.eur.nl/fsw/staff/homepages/engbersen/
Website CIMIC: http://www.eur.nl/fsw/research/cimic/
List of recent publications:
Godfried Engbersen, Kees Schuyt, Jaap Timmer and Frans van Waarden
(2006). Cultures of Unemployment. A Comparative Look at Unemployment
and Urban Poverty (Second print with a new introduction). Amsterdam:
Amsterdam University Press
Snel, Erik, Godfried Engbersen and Arjen Leerkes (2006). ‘Transnational
Involvement and Social Integration’. Global Networks. A Journal of
Transnational Affairs, Vol 6 (2): 285-308
Engbersen, Godfried, Marion van San and Arjen Leerkes (2006). ‘A room
with a view. Irregular immigrants in the legal capital of the world’.
Ethnography Vol 7 (2): 205-238
Engbersen, Godfried, Joanne van der Leun and Jan de Boom (2007). ‘The
Fragmentation of Migration and Crime.’ Crime and Justice. A Review of
Research, Vol. 33: 389-452
Broeders. Dennis and Godfried Engbersen (2007). ‘The Fight against
illegal Migration’. Identification Policies and Immigrants’ Counter
Strategies. American Behavioral Scientist, 50 (12): 1592-1609
Leerkes, Arjen, Godfried Engbersen and Marion van San (2007). ‘Shadow
Places. Patterns of Spatial Concentration and Incorporation in the
Netherlands.’ Urban Studies 44 (8): 1491-1516
Engbersen, G. & D. Broeders (2009). ‘The state versus the alien.
Immigration controls and strategies of irregular immigrants.’ West
European Politics, Vol. 32, nr. 5: 867 - 885
Van Meeteren, M.J., G. Engbersen, & M. van San (2009). ‘Striving for a
better position. Aspirations and the role of cultural, economic and social
capital for irregular migrants in Belgium’. International Migration Review.
Vol. 43 (4): 916-944
Van Bochove, Marianne, Katja Rusinovic & Godfried Engbersen (2010).
‘The Multiplicity of Citizenship: Transnational and Local Practices of
Middle-Class Migrants.’ Global Networks 10(3): 344-364.
Black, Richard, Godfried Engbersen, Marek Okólski & Cristina Panţîru
(eds.) (2010) A Continent Moving West? EU Enlargement and Labour
Migration from Central and Eastern Europe, Amsterdam: Amsterdam
University Press
Prof. Houtman 1
Department of Sociology
School/Depar Faculty of Social Sciences
Erasmus University Rotterdam
The Netherlands
tment:
Project Title: Gaming Together: (Re)constructing Social Capital in Online
Computer Games
Abstract:
Although media and academy alike still typically frame immensely popular
computer gaming by youngsters as a socially isolating activity, recent studies
suggest that in particular the new generation of online computer games (i.e.,
Everquest, World of Warcraft) stimulates the emergence of new forms of
sociality. This research project therefore aims to study the online construction
of ‘social capital’ (Putnam) and its consequences for offline social networks.
The study focuses on the influence of gaming activities on a) the pre-existing
offline ties with family, friends and peers (‘bonding’ social capital); b) the
construction of new social capital online and its possible role in transcending
cultural, ethnic and national differences (‘bridging’ social capital); and c) the
consequences of online social capital for gamers’ citizenship and offline
(perhaps transnational) social networks. Methodologically, the study
combines online surveys (data already available), aimed at mapping relations
between online and offline social capital, with in-depth interviewing and
(virtual) ethnography, aimed at exploring the role of online social capital in
the lives of those involved.
Requirements Background: (cultural) sociology, anthropology
of candidate: Skills in both quantitative and qualitative methods are preferred, but
project re-adjustment toward either of both is also possible
Master degree: yes
IELTS Grade: 7.0 (min. 6.0 per sub-score) or
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information:
Dr. Stef Aupers Website: http://www.eur.nl/fsw/staff/homepages/aupers/
Email: aupers@fsw.eur.nl
Prof. Dr. Dick Houtman Website: www.dickhoutman.nl
Email: houtman@fsw.eur.nl
Prof. Houtman 2.
School/Depar Faculty of Social Sciences Department of Sociology
Erasmus University Rotterdam The Netherlands
tment:
Project Title: From Faith in Science to Risk Society? Trust in Science and
Technology across Countries and over Time
Abstract:
Sociology features two major theories about changes in public trust
in science and technology. Modernization theory assumes public
trust in the feasibility of manipulating nature by means of science
and technology, so as to liberate mankind from nature-imposed
limitations, to keep pace with modernity’s unfolding. More recent
theories of reflexive modernization (Ulrich Beck and the like),
however, rather suggest a decline in public trust in science and
technology in advanced modernity.
Against this background, this project studies public evaluations of
science and technology in more and less modern contexts across
countries and over time. More specifically, it studies how levels of
modernity affect 1) public evaluations of science and technology,
conceived multi-dimensionally (trust in scientists, in scientific
institutions, in technology, etcetera) and 2) evaluations of various
specific groups and categories within the public at large.
Methodologically, using quantitative statistical methods, the study
analyses various sources of survey data (e.g. Eurobarometer, ISSP
data) aimed at mapping public trust in science and technology.
Requirements Background: sociology / social science
of candidate: Master degree: yes
IELTS Grade: 7.0 (min. 6.0 per sub-score)or
TOEFL: 100 (min. 20 per sub-score)
Supervisor
information:
Dr. Peter Achterberg
Website: www.peterachterberg.com Email: p.achterberg@fsw.eur.nl
Prof. Dr. Dick Houtman
Website: www.dickhoutman.nl Email: houtman@fsw.eur.nl
Institute of Social Studies
Dr. Meine Pieter van Dijk
School/Department:
Institute of Social Studies
Erasmus University Rotterdam
The Hague, The Netherlands
Project Title:
Climate Change and entrepreneurial response in rural China, the role of
local government and governance structures
Abstract:
Abstract
China is faced with challenging issues with regard to sustainable
development. One critical issue in this regard, is the problem of climate
change and its governance. How does China deal with the consequences of
climate change and is adaptation to climate change taking place at the local
level in China? The situation can be described as a multi-level governance
structure for drought management, the major consequence of climate change
in China. Seven levels can be distinguished between the national and the
natural village level, where farmers and local enterprises develop initiatives to
deal with climate change, which will be studied.
1. Description of the research
This research contrasts national top-down policies with the grass root level
initiatives of Chinese farmers and entrepreneurs in the framework of the
governance debate. Important external drivers in China such as the rapid
economic growth, urbanization, climate change and a growing awareness of
environmental degradation have contributed to a shift in governance
structures. These developments have created an enabling environment for
farmers and other entrepreneurs to take more initiatives. Furthermore,
decentralization, involvement of NGOs and CBOs in China and new
opportunities for initiatives for farmers and other entrepreneurs at the local
level. Farmers have their own competencies and resources and Orstrom
suggested factors which lead them to collective action. An analysis of the
multi-level governance structures in place will be carried out to determine the
role of local government and to assess to what extent the implementation of
policies and programs happen at the provincial or the local level. Farmers are
no passive by-standers, and take initiatives to deal with the many challenges
they are facing, which are partially climate change related, in particular the
increasing incidence of droughts. The research reviews the various reactions
to climate change through a large sample survey followed up by case studies
in one or two of China's most affected provinces.
2. Previous research in China by the supervisor
The importance of existing governance structures and the emerging initiatives
were analyzed in previous research in the Yunan province in Southern China.
We concluded that reactions can be classified as passive or active and using
existing or developing new governance structures (Hao Li and Van Dijk,
2011). Van Dijk and Liang (2011) analyze a shift in water governance at the
national level in China. More initiatives are developing at the household and
enterprise level to deal with drought. Other research on this topic is
summarized in Van Dijk (2006) and Van Dijk and Zhang Mingshun (2007).
3. Goal and expectations of the research
Drought in China and its consequences at different levels is an issue
of water governance. Specific about water governance is that it
covers all levels from local to global, it covers all actors from state to
non-state, it covers all relevant activities determining shape the use of
our resources and water governance implies norms, translated in
policies and social practices. Due to the drivers mentioned we
observe a shift in governance structures, resulting in more
opportunities for participation and local initiatives. Climate change
and a growing awareness of environmental degradation has helped to
create an environment in which governance is shifting. Governance is
shifting because of a different environment, economic incentives and
urgent events such as climate change and a growing awareness that
another approach is needed than the top-down and command and
control approach. The shifts in governance are facilitated by more
emphasis on decentralization. According to the constitution, the
national laws made by the National People’s Congress (or its
Standing Committee) set the principles, for example for dealing with
climate change. The national and local ordinances, which are passed
by the State Council or local councils, are used to work out the
details. Subsequently, the ministry or local government concerned
design their own rules (according to their responsibilities) to
implement law and ordinance. Governance is embedded in a larger
system of regional, provincial, municipal and district level
government structures.
4. Research design and questions
This research contrasts national top-down policies with the grass root level
initiatives of Chinese farmers in provinces where seasonal droughts have
become more important recently. An analysis of the multi-level governance
structures in place may show on the one hand that the implementation of
policies and programs frequently gets stranded at the provincial or the local
level. On the other hand, that farmers and entrepreneurs are no passive
by-standers, and take initiatives to deal with the many challenges they are
facing, which are partially climate change related. The major research
question is: what kind of policies and governance structures are in place in
South-western China to deal with the drought consequences of climate
change, and what factors explain their comparative effectiveness? More
specifically we want to know:
1. How are climate change policies and programs implemented at
different levels of government?
2. Which organizational framework has been adopted by China to
implement these policies and programs?
3. What are the effects on the farmer and enterprise level?
4. Which initiatives do the farmers and local entrepreneurs take
themselves to deal with the consequences of climate change, in
particular with drought?
5. Which factors explaining success and failure of these collective
efforts and governance structures?
5. Time table for the research
2012
2013
Elaboration
research
proposal
First
study
Theoretical
framework &
prev.research
Development
of
questionnaire
Second
study
Choices
concerning
location
Analysis first
case study
Analysis
of
second case
case
2014
2015
Survey
Comparative
analysis
case Generalization
Recommendations
& write up
6. Expected applicability
The practical relevance of this research is clear, but the results need to be
communicated to the policy makers and users. From the second year on
attention will be given to the dissemination of the results.
Requirements
candidate:
of Background: Economics or another social science
Supervisor information:
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score)
Or
TOEFL: 100 (min. 20 per sub-score)
Supervisor: Dr. Meine Pieter van Dijk
E-mail: mpvandijk@iss.nl,
Published articles 2011
1. Liang, X. and M.P. van Dijk (2011). Economic and financial analysis
on rainwater harvesting for agricultural irrigation in the rural areas of
Beijing. In: Resources, conservation and recycling, Vol. 55, pp
1100-1109.
2. With Hao Li (2011). Climate change and governance structures in
China. In International Journal of water, Vol. X
Published articles/books 2010
1. Liang, X. and Dijk, M.P. van (2010), Financial and economic
feasibility of decentralized waste water reuse systems in Beijing. In:
Water science and technology, 61(8).
2. Eco cities, Better cities, Better life? Experiences of European and
Asian cities, in particular Beijing and Rotterdam. In: Shelter, HSMI
HUDCO New Delhi, Vol. 12, No. 2, October.
3. The contribution of cities to economic development based on Chinese
and Indian cities. Saarbrucken: Lap.
Articles & books 2009
Tanzania: Uneven Growth, Policy Reforms and Poverty Alleviation: An
Example of an African Success? In: African Development 14.
Dijk, M.P. van (ed., 2009): The new presence of China in Africa, the
importance of increased Chinese trade, aid and investments for Sub Saharan
Africa. Amsterdam: Amsterdam University Press.
Articles 2008
Public-private partnerships in basic service delivery: impact on the poor,
examples from the water sector in India in: International Journal of Water Vol.
4, No. 3/4, 2008, pp. 216-235.
Why China’s grow will stop and Europe has something to offer (In Dutch:
Waarom de Chinese groei zal vastlopen en Europa iets te bieden heeft). In:
Fiducie, Vol. 15, No. 4.
Books and edited volumes 2008
With J. Fransen (eds, 2008): Managing Ethiopian cities in an era of rapid
urbanization. Delft: Eburon, 249 pages.
Private sector involvement in drinking water supply: the experience Special
issue International Journal of Water, Vol. 4, No. 3/4, 2008.
Articles 2007
China’s aanwezigheid in Afrika, In: Economisch Statistische Berichten (ESB),
5-10-2007, Jaargang 92, No. 4519, pp. 584-588
with Zhang Mingshun Urban environmental and economic performance
linked to sustainability: Evidence from big and medium size Chinese cities.
Rotterdam: working papers IHS No. 15, 23 pages. www.ihs.nl
Different effects of globalization for workers and poor in China and India,
Comparing countries, clusters and ICT clusters? In: Journal of Economic and
Social Geography, Dossier Globalization and workers, Vol. 97, No. 5, pp.
463-470.
Visser, E.J. and M.P. van Dijk, 2006, Economic globalization and workers:
introduction, In: Journal of Economic and Social Geography, Dossier
Globalization and workers, Vol. 97, No. 5, pp. 503-515.
Incorporating informality. In: Shelter HSMI New Delhi, Vol. 9, No.
4, December, pp. 14-21.
Book 2006
Managing cities in developing countries, The theory and practice of
urban management. Cheltenham: Edward Elgar, in Chinese: Beijing:
Renmin university Press, World Bank series, 1-198.
PhD. Bert Helmsing
School/Department: Institute of Social Studies
Erasmus University Rotterdam
The Hague, The Netherlands
Project Title:
Variety of capitalism and local economic development: the evolving role of local
authorities in China
Abstract:
Globalization encompasses the growing mobility of financial and investment capital,
the growing mobility of firms and the international spread of networked production
activities and the increasing mobility of unskilled and highly skilled people who
search for better economic opportunities. At the same time globalization increases
the competition between countries and localities to attract capital, firms and people
to advance their own territorial development. Globalisation and growing territorial
competition take place against the background of historically very differently
evolved country specific ‘varieties of capitalism’. The research proposed here is part
of a larger research effort which seeks to explore to what extent there is a broad
correspondence between a particular variety of capitalism and the prevailing LED
policy regime and seeks to test two alternative hypotheses: convergence or
continued diversity of LED policy regimes?
In China the state plays and much larger role in the economy and local and regional
governments also play de facto an important role in the promotion of local economic
development, but relatively little is know about in the international development
literature, how Chinese economic success was based on local level initiatives.
1. Description of the research
Globalization and growing territorial competition take place against the background
of historically very differently evolved country or supra regional specific ‘varieties
of capitalism’ (Hall & Soskice, 2003). These varieties of capitalism concern critical
differences in: a) the nature of doing business, b) the role of the state and c) the
relationships between state and business. Hall and Soskice identified two major
types, namely, liberal market economies and coordinated market economies. Since
then further types of varieties of capitalism have been identified for Latin America
(Schneider, 2009), In Asia (Carney et al, 2009) and Eastern Europe (Nolke &
Vliegenthart, 2009) .
In the practice of local economic development promotion in different parts of the
world, one can also observe important systemic differences. In Sub-Saharan Africa
late developing countries have as yet not been capable to develop strategic
coordination Helmsing (2005, 2007, 2010). Most LED programs are donor funded
and have a poverty rather than an economic development focus (Rodriguez-Pose &
Tijmstra, 2007). A noteworthy exception is South Africa (Rogerson, 2000 and
Rogerson & Rogerson, 2010).
In Latin America the wave of decentralization which spread over the continent in the
1990s has triggered widespread innovation in local economic development
interventions. One of the key features of local economic development policy in
Latin America is the central role of meso-institutions i.e. institutions at the level of
sector and region which facilitate such public-private interaction (Helmsing, 2001,
2004). These innovative institutions however are mainly focused on formal domestic
enterprises and business groups and do not involve the large base of small and
informal enterprises. In North America and especially in the US local economic
development is strictly a local government affair without any direct involvement of
the federal government (Valler & Wood, 2010). Local economic development policy
as a means of non-market coordination is largely absent and place competition and
the use of financial and fiscal incentives predominate (Rees, 2006). This is
consistent with the liberal market character of the economy.
In Europe social cohesion has been a point of departure for local regional policy.
Regional Structure Fund is the second largest EU fund. Europe has much more state
centric administrative institutional arrangements in which business participates.
Public-private interaction involves multiple levels of government. Within European
countries local governments have undertaken their own initiatives to promote the
economic development of their jurisdictions, generating further diversity (Helmsing,
2010). Europe local economic development policy regime is consistent with the
coordinated market economy character of European economies.
In China district authorities (Van Dijk, 2006) and county and village level authorities
play an important role in LED (Van Dijk and Hao Li 2011) but relatively little is
known about it the international development literature, how Chinese economic
success was based on local level initiatives.
2. Previous research in China by the supervisors
Helmsing published extensively on local economic development and on the role of
local governments in different parts of the world (e.g. Helmsing, 2005, 2007, 2008,
2010, 2011). Van Dijk did research in China since 1996 and is in particular
interested in the role of local governments for economic development (Van Dijk,
2006 and 2007). His research on the role of urban management in the development
of China’s cities has been published in Chinese in 2006 by Renmin University Press.
3. Goal and expectations of the research
The objective of this research is to examine the LED policy regime in China and
identify its embedding in the Chinese variety of capitalism and to assess to what
extent there is a convergence in the LED policy regime with that of other major
economies.
4. Research design and questions
The research questions are:
1) How is the role of different types of local authorities in the promotion of local
economic development conceptualized in China?
2) What are principal drivers and instruments used in LED promotion by local
authorities?
3) As China’s role in the global economy increases, is there a convergence with LG
policy regimes in other major economies or is there a continued diversity in policy
regimes consistent with the variety of capitalism which dominates in particular
major economies?
5. Time table for the research
The methodology consist of two parts:
a) a review of literature on LED in China and its comparison with literature on LED
policy regimes in other major economies in the world
b) case study research of an ‘illustrative’ sample of local authority practices and
interviews with the concerned entrepreneurs and government officials.
2012
2013
2014
2015
Elaboration
research
proposal
Sampling
Case study
research
Comparative
analysis
Theoretical
Development
Survey
Generalization
framework &
prev.research
and testing of
questionnaire
and
interviews
Choices
concerning
location
Analysis
studies
pre-test
Analysis of
case
studies
case
&
Recommendations &
write up
6. Expected applicability
The practical relevance of this research is clear, but the results need to be
communicated to the policy makers and users, notably in Central and Local
Government Officials. From the second year on attention will be given to the
dissemination of the results to local government officials and academic colleagues.
References
Bartik, T. J. (2004). Local Economic Development policies. In: Aronson, J.R.&
Schwartz, E.. eds. 2004. Management policies in local government finance (pp 355-390).
Washington: International City/County Management Association.
Carney, et al. (2009) Varieties of Asian capitalism: toward an institutional theory of
enterprise. Asia Pacific Journal of Management, 26, 361-380
Hall P & Soskice, D (eds) (2001) Varieties of Capitalism: the institutional foundations of
comparative advantage. New York.
Helmsing, A.H.J. (2003). Local economic development. New generations of actors,
policies and instruments. Public Administration and Development, vol 23, no 1, 67-76.
Helmsing, A.H.J. (2002). Partnerships, meso-institutions and learning: new local and
regional economic development initiatives in Latin America. In: Baud, I, and Post, J.
(eds) Re-aligning actors in an urbanizing world. Governance and institutions from a
development perspective. p. 79-101, Aldershot: Ashgate.
Helmsing, A.H.J., & Egziabher T.G. (2005). Local Economic Development In Africa,
Enterprises, Communities and Local Government. Maastricht: Shaker Publishing.
Reese, L. A. (2006). Do we really need another typology? Clusters of local economic
development strategies. Economic Development Quarterly 20(4): 368-376.
Rodriguez-Pose, A. & Tijmstra, S.A.R. (2007). Local economic development in
sub-Saharan Africa. Environment & Planning C: Government and Policy, 25, 516-36
Rogerson, C.M. (2000). Local economic development in an era of globalisation: the case
of South African cities. TESG, 91, 397 - 411.
Schneider, B R. (2009) Hierarchical market economies and varieties of capitalism in
Latin America, Journal of Latin American Studies, 41, 553-575
Valler, D. &. Wood., A (2010). Conceptualizing local and regional economic
development in the USA. Regional Studies 44(2): 139-151.
Requirements
candidate:
Supervisor
information:
of Background: Regional economics and economic geography.
Master degree: Yes
IELTS Grade: 7.0 (min. 6.0 per sub-score)
or
TOEFL: 100 (min. 20 per sub-score)
Supervisor: PhD. A.H.J (Bert) Helmsing
E-mail: helmsing@iss.nl
Website: http://www.iss.nl/iss/profile/AC1170
Co-Supervisor: Dr. Meine Pieter van Dijk
E-mail: mpvandijk@iss.nl
Published articles 2011
Helmsing, A.H.J. & Ellinger Fonseca, P. 2011. La economia politica institucional del
desarrollo local: dos historias de turismo en Brasil. Revista de Estudios Urbanos y
Regionales, vol 37, nr 110, pp 31-57.
Liang, X. & M.P. van Dijk (2011). Economic and financial analysis on rainwater
harvesting for agricultural irrigation in the rural areas of Beijing. In: Resources,
conservation and recycling, Vol. 55, pp 1100-1109.
Dijk, van M.P. & Hao Li (2011). Climate change and governance structures in China. In
International Journal of water, Vol. X
Books and edited issues 2011
Helmsing, A.H.J. & Vellema, S. eds. 2011. Value Chains, inclusion and economic
development. Milton Park: Routledge
A. Bongwa, S. Kasahun and M. P. van Dijk (eds., 2011): Decentralisation and
Ethiopian cities, its impact on service delivery and development.
Maastricht: Shaker.
M.P. van Dijk & J. Trienekens (eds., 2011): Global value chains linking local producers
from developing countries to international markets. Amsterdam: University Press.
Dijk, M.P. van (ed., 2011): Water governance, the experience Special issue International
Journal of Water, Vol. x, No. y, pp.
Published articles 2010
Helmsing, A.H.J. (2010) Place prosperity: between openness and control. Perspectives
and practices of local economic development. Paper presented at the International Forum
on Regional Development 2010. organized by Ministry of Knowledge Economy,
November 22-25. Seoul, Republic of Korea.
Ayelech Tiruwha Melese & A.H.J. Helmsing. 2010. Endogenisation or enclave
formation? The development of the Ethiopian cut flower industry. Journal of Modern
African Studies, Vol.48 No.1, 35-66.
Liang, X. and M.P. van Dijk, Financial and economic feasibility of decentralized waste
water reuse systems in Beijing. In: Water science and technology, 61(8) pp. 1965-1974.
Van Dijk, M.P. International trends in city management, in: Journal of Town & City
management, Vol. 1, Number 1, June-August 2010.
Van Dijk, M.P. Eco cities, Better cities, Better life? Experiences of European and Asian
cities, in particular Beijing and Rotterdam. In: Shelter, HSMI HUDCO New Delhi, Vol.
12, No. 2, October 2010, pp. 122-134.
Books 2010
J. Fransen, M.P. van Dijk and S. Kassahun (eds., 2010): Formalization and
informalization processes in urban Ethiopia: incorporating informality. Maastricht:
Shaker, 219 pages.
M.P. van Dijk (2010): The contribution of cities to economic development, An
explanation based on Chinese and Indian cities. Saarbrucken: Lap.
Articles 2009
M.P. van Dijk Tanzania: Uneven Growth, Policy Reforms and Poverty Alleviation: An
Example of an African Success? In: African Development Yearbook 14, pp. 243-267.
M.P. van Dijk Kan het Chinese exportmodel de internationale financiële crisis over
leven? In: Kwartaalschrift Economie, Vol. 6, No. 3, pp. 337-57.
Books and edited volumes 2009
Dijk, M.P. van (ed., 2009): The new presence of China in Africa, the importance of
increased Chinese trade, aid and investments for Sub Saharan Africa. Amsterdam:
Amsterdam University Press.
Articles 2008
Gomez, G. & Helmsing, A.H.J. 2008. Selective spatial closure and local economic
development: what do we learn from the Argentine local currency systems? World
Development, 36, 2489-2511
M.P. van Dijk The impact of the sub prime crisis on sustainable housing finance. In:
Shelter on Housing finance and policy. New Delhi: HSMI/HUDCO, pp. 131-142.
M.P. van Dijk Why China’s grow will stop and Europe has something to offer (In Dutch:
Waarom de Chinese groei zal vastlopen en Europa iets te bieden heeft). In: Fiducie, Vol.
15, No. 4, pp. 23-29.
Books and edited volumes 2008
M.P. van Dijk and J. Fransen (eds, 2008): Managing Ethiopian cities in an era of rapid
urbanization. Delft: Eburon, 249 pages.
Dijk, M.P. van (ed., 2008): Private sector involvement in drinking water supply: the
experience Special issue International Journal of Water, Vol. 4, No. 3/4, 2008, 161 p
Articles 2007
Helmsing, A.H.J. (2007). Competitiveness and Decentralisation in SubSaharan Africa: is
there competency for policy at the local and regional levels? Regional Development
Dialogue, 28, 1, 1-23
M.P. van Dijk China’s aanwezigheid in Afrika, In: Economisch Statistische Berichten
(ESB), 5-10-2007, Jaargang 92, No. 4519.
M.P. van Dijk, Breaking the vicious circle of urban insecurity, examples from developed
and developing countries. In: Shelter, Vol. 10, No. 3, October 2007, pp. 38-44.
Book and working papers in 2007
M.P. van Dijk and Zhang Mingshun Urban environmental and economic performance
linked to sustainability: Evidence from big and medium size Chinese cities. Rotterdam:
working papers IHS No. 15, 23 pages.
Articles 2007
Helmsing, A.H.J. 2007. Competitiveness and Decentralisation in SubSaharan Africa: is
there competency for policy at the local and regional levels? Regional Development
Dialogue, 28, 1, 1-23
M.P. van Dijk Different effects of globalization for workers and poor in China and India,
Comparing countries, clusters and ICT clusters? In: Journal of Economic and Social
Geography, Dossier Globalization and workers, Vol. 97, No. 5, pp. 463-470.
Visser, E.J. and M.P. van Dijk, 2006, Economic globalization and workers: introduction,
In: Journal of Economic and Social Geography, Dossier Globalization and workers, Vol.
97, No. 5.
M.P. van Dijk, Incorporating informality. In: Shelter HSMI New Delhi, Vol. 9, No. 4,
December, pp. 14-21.
Books 2006
M.P. van Dijk, Managing cities in developing countries, The theory and practice of urban
management. Cheltenham: Edward Elgar. 212 pages, in Chinese: Beijing: Renmin
university Press, World Bank series, 1-198.