CURRICULUM VITAE
Firstname : SHARSHAR Surname: Tarek
 22 May 1964
 Nationality : French
 Married – One child
Personal address :
10, Square Port-Royal
75013 Paris France
Professional address :
Intensive care department
Raymond Poincaré Hospital
104, Boulevard Raymond Poincaré
92380 Garches France
00 33 (0)1 47 10 77 80
2013
2013
2012
2011
2009-2011
2009
2008
2007
2006
2003 – 2005
2001 – 2003
2000 – 2001:
1996-2000
1998:
1996 :
1996 :
Project of Master 2 in Reserarch “Neurosciences of Acute Brain Injury”
Submitted to Ministère de l’Enseignement Supérieur et de la Recherche
Co-Organiser of Versailles International Neurocritical Care Symposium on
“Science of Consciousness in Acute Neurological Disorders”. Palais des
congrès de Versailles – June 20 et 21st 2013
Co-Organiser of Versailles International Neurocritical Care Symposium on
“Brain Injury, Brain repair, From Bench to Bedside”. Palais des congrès de
Versailles – June 21et 29Juin
Co-Organiser of Versailles International Neurocritical Care Symposium on
Delirium in ICU. Palais des congrès de Versailles – June 28th et 29th 2
Coordinator of university diploma in Neurointensive Care Medicine University of Versailles Saint-Quentin en Yvelines
Member of the Round Table in ICU-acquired Paresis (ISICEM, Brussels)
Coordinator of the regional training in Neurointensive Care Medicine for
diploma in Intensive Care Medicine
Professor in Intensive Care Medicine – University of University of Versailles
Saint-Quentin en Yvelines
Qualification to supervise research ( Habilitation à diriger des recherches).
University of Versailles Saint-Quentin en Yvelines.
Consultant in intensive care unit in the teaching hospital Raymond Poincaré
(Professor D Annane) – Garches, France.
PhD in Respiratory Muscle Laboratory in Royal Brompton Hospital (Dr M.
Polkey, Imperial College).
Consultant in Lung Function Laboratory in the teaching hospital Raymond
Poincaré (Professor F. Lofaso) - Garches, France.
Medical Registrar in intensive care unit in the teaching hospital Raymond
Poincaré (Professor Ph. Gajdos) - Garches, France.
Diploma in critical care medicine
Higher Degree in Molecular and cellular Pharmacology
Supervisor : Professor Ph. Ascher and Professor M. Kazatchkine
Selective Impairment of serum antibody repertoires toward muscle and
thymus in patients with seropositive and seronegative myasthenia gravis.
Medical thesis
Supervisor: Professor J.L. Mas
Incidence and causes of stroke during pregnancy and puerperium. A study in
public hospitals of Ile de France. Stroke.
1996 :
1995 :
1990:
Diploma in Neurology
Supervisor: Professor Y Agid and Professor O Lyon-Caen
Diploma in Statistics applied to medical research
Concours de l’internat d’Ile de France.
CURRENT RESEARCH ACTIVITY
1 – Neuropathological research on Blood-Brain Barrier dysfunction, microglial activation and
microglial-astrocytes interaction in human and experimental sepsis. Collaboration with
Pr Fabrice Chrétien, Institut Pasteur, Paris, France;
Pr Greet van den Berghe, University of Leuven, Belgium
2 – Investigation of septic shock related osmoregulation dysfunction. Collaboration with
Pr Charles Bourques, Mc Gill University
3 – Clinical and Neurophysiological of brainstem dysfunction in critically ill patients. Collaboration
with
Pr Jean Mantz University Denis Diderot, Hôpital Beaujon
4 – Pathophysiology and outcomes of critical illness neuromyopathy Collaboration with
Pr Fabrice Chrétien, Institut Pasteur, Paris, France;
5 – Multicentre randomized clinical trials on steroids tapering in patients with myasthenia gravis
(current inclusion)
6 – Multicentre randomized trial on impact of long term follow-up of patients discharged from ICU
(Grant accepted in 2010)
7 – Multicentre randomized trial on intravenous valproate as adjunctive anti-epileptic drug in status
epilepticus (Grant accepted in 2010)
8 – Bicenter study on Impact of exercise on quality of life of patients with Myasthenia Gravis (Grant
accepted in 2012)
9 – Clinical and Neurophysiological assessment of Brainstem dysfunction in Critically ill Patients
(Grant accepted in 2012)
SUPERVISING OF MASTER 2 AND PHD STUDENTS
From 2007 to 2013: 7 Master 2 students
From 2007 to 2013: 3 PhD students
PUBLICATIONS
Indice H: 36 (google scholar)
Citations: 5683 (google scholar)
ORIGINAL ARTICLES (in peer-reviewed journals ; n=70)
1
AZABOU E, FISCHER C, MAUGUIERE F, VAUGIER I, ANNANE
D, SHARSHAR T, LOFASO F. Prospective Cohort Study Evaluating the Prognostic Value of
Simple EEG Parameters in Postanoxic Coma. Clin EEG Neurosci. 2015 accepted.
2
AZABOU E, MAGALHAES E, BRACONNIER A, YAHIAOUI L, MONEGER G,
HEMING N, ANNANE D, MANTZ J, CHRÉTIEN F, DURAND MC, LOFASO F,
PORCHER R, SHARSHAR T; Groupe d’Explorations Neurologiques en Réanimation
(GENER). Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic
Intensive Care Unit Patients. Plosone 2015; 10(10):e0139969
3
STARE J, SIAMI S, TRUDEL E, PRAGER-KHOUTORSKY M, SHARSHAR T,
BOURQUE CW. Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons
Mediating Thirst and Vasopressin Release. J Neurosci. 2015 ; 35(35):12188-97.
4
TSONIS AI, ZISIMOPOULOU P, LAZARIDIS K, TZARTOS J, MATSIGKOU E,
ZOUVELOU V, MANTEGAZZA R, ANTOZZI C, ANDREETTA F, EVOLI A, DEYMEER F,
SARUHAN-DIRESKENELI G, DURMUS H, BRENNER T, VAKNIN A, BERRIH-AKNIN S,
BEHIN A, SHARSHAR T, DE BAETS M, LOSEN M, MARTINEZ-MARTINEZ P, KLEOPA KA,
ZAMBA-PAPANICOLAOU E, KYRIAKIDES T, KOSTERA-PRUSZCZYK A, SZCZUDLIK P,
SZYLUK B, LAVRNIC D, BASTA I, PERIC S, TALLAKSEN C, MANIAOL A, CASASNOVAS
PONS C, PITHA J, JAKUBÍKOVA M, HANISCH F, TZARTOS SJ. MuSK autoantibodies in
myasthenia gravis detected by cell based assay--A multinational study. J Neuroimmunol. 2015 Jul
15;284:10-7.
5
SONNEVILLE R, DERESE I, MARQUES MB, LANGOUCHE L, DERDE S, CHATRE L,
CHRÉTIEN F, ANNANE D,SHARSHAR T, VAN DEN BERGHE G, VANHOREBEEK I.
Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice.
Shock. 2015 ; 44:245-51.
6
PENE F, AIT-OUFELLA H, TACCONE FS, MONNERET G, SHARSHAR T, TAMION F,
MIRA JP; Commission de Recherche Translationnelle de la Société de Réanimation de Langue
Française (SRLF). Insights and limits of translational research in critical care medicine. Ann
Intensive Care. 2015 30;5:8.
7
LAI A, OUTIN HD, JABOT J, MÉGARBANE B, GAUDRY S, COUDROY R, LOUIS G,
SCHNEIDER F, BARBAROT N, ROCH A, LEROLLE N, LUIS D, FOURRIER F, RENAULT A,
ARGAUD L, SHARSHAR T, GIBOT S, BOLLAERT PE. Functional outcome of prolonged
refractory status epilepticus. Crit Care 2015 30; 19:199.
8
SUTTER R, CHALELA JA, LEIGH R, KAPLAN PW, YENOKYAN G, SHARSHAR T,
STEVENS RD. Significance of Parenchymal Brain Damage in Patients with Critical Illness.
Neurocrit Care 2015
9
SHARSHAR T, CITERIO G, ANDREWS PJ, CHIEREGATO A, LATRONICO N, MENON
DK, PUYBASSET L, SANDRONI C, STEVENS RD. Neurological examination of critically ill
patients: a pragmatic approach. Report of an ESICM expert panel. Intensive Care Med.
2014Apr;40:484-95
10
SIAMI S, POLITO A, PORCHER R, HISSEM T, BLANCHARD A, BOUCLY C, CARLIER
R, ANNANE D, HAYMANN JP, SHARSHAR T. Thirst perception and osmoregulation of
vasopressin secretion are altered during recovery from septic shock. PLoS One 2013
11
POLITO A, EISCHWALD F, MAHO AL, POLITO A, AZABOU E, ANNANE D,
CHRÉTIEN F, STEVENS RD, CARLIER R, SHARSHAR T. Pattern of Brain Injury in the Acute
Setting of Human Septic Shock. Crit Care 2013
12
AZABOU E, ROCHE N, SHARSHAR T, BUSSEL B, LOFASO F, PETITJEAN
M.Transcranial direct-current stimulation reduced the excitability of diaphragmatic corticospinal
pathways whatever the polarity used. Respir Physiol Neurobiol. 2013 189 : 183-7.
13
Nardi O, Polito A, Aboab J, Colin G, Maxime V, Clair B, Friedman D, Orlikowski D,Sharshar
T, Annane D. StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a
pilot randomised trial. J Clin Monit Comput. 2013 27:215-21.
14
SHARSHAR T, POLITO A, PORCHER R, MERHBENE T, BLANC M, ANTONA M,
DURAND MC, FRIEDMAN D, ORLIKOWSKI D, ANNANE D, MARCADET MH. Relevance of
anxiety in clinical practice of Guillain-Barre syndrome: a cohort study. BMJ Open. 2012 pii:
e000893. doi: 10.1136/bmjopen-2012-000893.
15
HOPKINSON NS, SHARSHAR T, DAYER MJ, LOFASO F, MOXHAM J, POLKEY MI.
The effect of acute non-invasive ventilation on corticospinal pathways to the respiratory muscles in
chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2012 183(1):41-7.
16
SONNEVILLE R, DEN HERTOG HM, GÜIZA F, GUNST J, DERESE I, WOUTERS PJ,
BROULAND JP, POLITO A, GRAY F, CHRÉTIEN F, CHARLIER P, ANNANE D, SHARSHAR T,
VAN DEN BERGHE G, VANHOREBEEK I. Impact of hyperglycemia on neuropathological
alterations during critical illness. J Clin Endocrinol Metab. 2012 97(6):2113-23.
17
POLITO A, SONNEVILLE R, GUIDOUX C, BARRETT L, VILTART O, MATTOT V,
SIAMI S, LORIN DE LA GRANDMAISON G, CHRETIEN F, SINGER M, GRAY F, ANNANE D,
BROULAND JP, SHARSHAR T.Changes in CRH and ACTH Synthesis during Experimental and
Human Septic Shock. PLoS One. 2011;6(11):e25905
18
COLIN G, NARDI O, POLITO A, ABOAB J, MAXIME V, CLAIR B, FRIEDMAN D,
ORLIKOWSKI D, SHARSHAR T, ANNANE D. Masseter tissue oxygen saturation predicts normal
central venous oxygen saturation during early goal-directed therapy and predicts mortality in patients
with severe sepsis. Crit Care Med. 2011
19
A POLITO, JP BROULAND, R PORCHER, R SONNEVILLE, S SIAMI, RD STEVENS,
GUIDOUX C, V MAXIME, G LORIN DE LA GRANDMAISON, F CHRETIEN, F GRAY, D
ANNANE, T SHARSHAR. Hyperglycaemia and apoptosis of microglial cells in human septic shock.
Crit Care. 2011 15(3):R131.
20
M SCHMIDT, A. DEMOULE, A. POLITO, R. PORCHER, J. ABOAB, SIAMI S, C.
MORELOT-PANZINI, T. SIMILOWSKI, T. SHARSHAR. Dyspnea in mechanically ventilated
critically ill patients. Crit Care Med. 2011
21
T SHARSHAR, R PORCHER, S SIAMI, B ROHAUT, J BAILLY-SALIN, NS
HOPKINSON, B CLAIR, C GUIDOUX; E IACOBONE, R SONNEVILLE, A POLITO, J ABOAB, S
GAUDRY, O MORLA, G AMOUYAL, J AZUAR, J ALLARY, A VEILLARD-BARON, M WOLF,
A. CARIOU, D ANNANE. Brainstem responses can predict death and delirium in sedated paztients
in intensive care unit. Crit Care Med 2011 39 :1960-7.
22
D ORLIKOWSKI, R PORCHER, V SIVADON-TARDY, JC QUINCAMPOIX, RAPHAËL
JC, MC DURAND, T SHARSHAR, J ROUSSI, C CAUDIE, D ANNANE, F ROZENBERG, M
LERUEZ-VILLE, JL GAILLARD, E GAULT. Guillain-Barré syndrome following primary
cytomegalovirus infection: a prospective cohort study. Clin Infect Dis. 2011 52: 837-44
23
SHARSHAR T, BASTUJI-GARIN S, POLITO A, DE JONGHE B, STEVENS RD,
MAXIME V, RODRIGUEZ P, CERF C, OUTIN H, TOURAINE P, LABORDE K; THE GROUPE
DE REFLEXION ET D'ETUDE DES NEUROMYOPATHIES EN REANIMATION. Hormonal
status in protracted critical illness and in-hospital mortality. Crit Care. 2011 15: R47.
24
V MARTINEZ V, D FLETCHER D, F MARTIN F, D ORLIKOWSKI D, T SHARSHAR, M
CHAUVIN, D BOUHASSIRA, N ATTAL. Small fibre impairment predicts neuropathic pain in
Guillain-Barré syndrome. Pain 2010 151:53-60
25
S SIAMI, J BAILLY-SALIN, A POLITO, R PORCHER, A BLANCHARD , JP HAYMANN,
K LABORDE, V MAXIME, C BOUCLY, R CARLIER, D ANNANE, T SHARSHAR.
Osmoregulation of vasopressin secretion is altered in the postacute phase of septic shock. Crit Care
Med. 2010 38: 1962-9
26
POLITO A, G LORIN DE LA GRANDMAISON, A MANSART , E LOUISET, H
LEFEBVRE, T SHARSHAR , D ANNANE. Human and experimental septic shock are characterized
by depletion of lipid droplets in the adrenals. Intensive Care Med. 2010 36: 1852-8.
27
T. SHARSHAR, BASTUJI-GARIN S, DE JONGHE B, STEVENS RD, POLITO A,
MAXIME V, RODRIGUEZ P, CERF C, OUTIN H, TOURAINE P, LABORDE K. Hormonal status
and ICU-acquired paresis in critically ill patients. Intensive Care Med. 2010 36: 1318-26
28
V. SIVADON-TARDY, ORLIKOWSKI D, PORCHER R, RONCO E, CAUDIE C, ROUSSI
J, FAUCHÈRE JL, MÉGRAUD F, TABOR H, T. SHARSHAR, ANNANE D, RAPHAËL JC,
GAILLARD JL. Detection of Campylobacter jejuni by culture and real-time PCR in a French cohort
of patients with Guillain-Barre syndrome. J Clin Microbiol. 2010 48: 2278-81
29
R SONNEVILLE, C GUIDOUX, L BARRETT, O VILTART, V MATTOT, A POLITO, S
SIAMI, GL DE LA GRANDMAISON, A BLANCHARD, M SINGER, D ANNANE, F GRAY, JP
BROULAND, T SHARSHAR. Vasopressin Synthesis by the Magnocellular Neurons is Different in
the Supraoptic Nucleus and in the Paraventricular Nucleus in Human and Experimental Septic Shock.
Brain Pathology 2010 20: 613-22
30
T. SHARSHAR, S. BASTUJI-GARIN, RD. STEVENS, MC. DURAND, I. MALISSIN, P.
RODRIGUEZ, C. CERF, H. OUTIN, B. DE JONGHE FOR THE GROUPE DE REFLEXION ET
D’ETUDE DES NEUROMYOPATHIES EN REANIMATION (GRENER). Presence and severity of
ICU-Acquired paresis at the time of awakening are associated with increased ICU and hospital
mortality. Crit Care Med. 2009; 37: 3047-3053
31
J. STRAUSS, J. ABOAB, M. ROTTMAN, R. PORCHER, L. IKKA, A. POLITO, M-C
DURAND, D. ORLIKOWSKI, C. DEVAUX, F. LOFASO, D. ANNANE, J-L. GAILLARD, T.
SHARSHAR. Plasma cortisol levels in Guillain-Barré syndrome. Crit Care Med. 2009; 37: 24362440
32
V. SIVADON-TARDY, D. ORLIKOWSKI, R. PORCHER, T. SHARSHAR, MC DURAND,
V ENOUF, F. ROZENBERG, C. CAUDIE, D ANNANE, S VAN DER WERF, P LEBON, JC
RAPHAËL, JL GAILLARD, E GAULT. Guillain-Barré syndrome and influenza virus infection. Clin
Infect Dis. 2009 ; 48: 48-56
33
D. OLIKOWSKI, N. TERZI, M. BLUMEN, T. SHARSHAR, J-C. RAPHAEL, D. ANNANE,
F. LOFASO. Tongue weakness is associated with respiratory failure in patients with severe GuillainBarré syndrome. Acta Neurol Scand. 2008; 119: 364-370
34
J. ABOAB, A. POLITO, D. ORLIKOWSKI, T. SHARSHAR, M. CASTEL, D. ANNANE.
Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach. Crit
Care Med. 2008; 36: 1481-6.
35
B. DE JONGHE, S. BASTUJI-GARIN, M.C. DURAND, I. MALISSIN, P. RODRIGUES, C.
CERF, H. OUTIN, T. SHARSHAR. Respiratory weakness is associated with limb weakness and
delayed weaning in critical illness. Crit Care Med 2007; 35: 2007-2005
36
T. SHARSHAR, R. CARLIER, F. BERNARD, C. GUIDOUX, J-P. BROULAND, O.
NARDI, G. L. DE LA GRANDMAISON, J. ABOAB, F. GRAY, D. MENON, D. ANNANE. Brain
lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med. 2007; 33: 798-806.
37
M.C. DURAND, R. PORCHER, D. ORLIKOWSKI, J. ABOAB, C. DEVAUX, B. CLAIR, D.
ANNANE, J-L. GAILLARD, F. LOFASO, J-C. RAPHAEL, T. SHARSHAR. Clinical and
electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study.
Lancet Neurol. 2006; 5:1021-1028.
38
D ORLIKOWSKI, T SHARSHAR, R PORCHER, D ANNANE, JC RAPHAEL, B CLAIR.
Prognosis and risk factors of early onset pneumonia in ventilated patients with Guillain-Barre
syndrome. Intensive Care Med. 2006; 32: 1962-1969
39
MJ DAYER, S JONVILLE, M CHATWIN, EB SWALLOW, R PORCHER, T SHARSHAR,
ET ROSS, NS HOPKINSON, J MOXHAM, MI POLKEY. Exercise-induced depression of the
diaphragm motor evoked potential is not affected by non-invasive ventilation. Respir Physiol
Neurobiol. 2006 (sous presse)
40
V SIVADON-TARDY, D ORLIKOWSKI, F ROZENBERG, C CAUDIE, T SHARSHAR, P
LEBON, D ANNANE, JC RAPHAEL, R PORCHER, JL GAILLARD. Guillain-Barre syndrome,
greater Paris area. Emerg Infect Dis. 2006;12: 990-993.
41
MC DURAND, H. PRIGENT, V. SIVADON-TARDY, D. ORLIKOWSKI, C. CAUDIE, C.
DEVAUX, B. CLAIR, J.L. GAILLARD, F. LOFASO, J.C. RAPHAEL, T. SHARSHAR. Significance
of phrenic nerve electrophysiological abnormalities in Guillain-Barre syndrome. Neurology. 2005; 65:
1646-1649.
42
M.J. DAYER, N.S. HOPKINSON, E.T. ROSS, S. JONVILLE, T. SHARSHAR, M.
KEARNEY, J. MOXHAM, M.I. POLKEY. Does symptom-limited cycle exercise cause low
frequency diaphragm fatigue in patients with heart failure? Eur J Heart Fail. 2005
43
T. SHARSHAR, N. HOPKINSON, E. ROSS, S. JONVILLE, M. DAYER, A. NICKOL, F.
LOFASO, J. MOXHAM, M. POLKEY. Motor control of the costal and crural diaphragm--insights
from transcranial magnetic stimulation in man. Resp Physiol and Neurobiol. 2005; 146: 5-19.
44
T. SHARSHAR, N. HOPKINSON, S. JONVILLE, M. DAYER, E. SWALLOW, J.
MOXHAM, F. LOFASO, M. POLKEY. Demonstration of a second rapidly cortico-diaphragmatic
pathway in humans. J Physiol (Lond). 2004, 560: 897-908.
45
N. HOPKINSON, T. SHARSHAR, E. ROSS, A. NICKOL, M. DAYER, F. LOFASO, J.
MOXHAM, M. POLKEY. Impaired effect of voluntary facilitation on the diaphragmatic response to
transcranial magnetic stimulation in patients with COPD. Resp Physiol and Neurobiol. 2004; 141: 112.
46
T. SHARSHAR, N.S. HOPKINSON, E.T. ROSS, A.H. NICKOL, Y. LUO, M. DAYER, N.
HART, J. MOXHAM, F. LOFASO, M. POLKEY. Effect of isocapnic mechanical ventilation on
costal and crural diaphragmatic response to transcranial magnetic stimulation. J Applied Physiol.
2004; 97: 3-12.
47
B. DE JONGHE, S. BASTUJI-GARIN, T. SHARSHAR, H.D. OUTIN, L. BROCHARD FOR
THE GRENER (GROUPE DE REFLEXION ET D’ETUDE DES NEUROMYOPATHIES EN
REANIMATION). Relationship between ICU Acquired Paralysis and duration of mechanical
ventilation in awakening ICU patients. Int Care Med. 30: 1117-1121.
48
T. SHARSHAR, D. ANNANE, G. LORIN DE LA GRANDMAISON, A. DORANDEU, N.
HOPKINSON, F. GRAY. The neuropathology of septic shock: a prospective case-control study.
Brain Pathology, 2004, 14 : 21-33.
49
T. SHARSHAR, F. GRAY, G. LORIN DE LA GRANDMAISON, A. DORANDEU, D.
ORLIKOWSKI, J.C. RAPHAEL, P. GAJDOS, N. HOPKINSON, D. ANNANE. Apoptosis and
inducible nitric oxide expression in autonomic centres controlling the cardiovascular system in human
septic shock. Lancet 2003; 362: 1799-1805.
50
N. HART, M. POLKEY, T. SHARSHAR, L. FALAIZE, B. FAUROUX, J.C. RAPHAËL, F.
LOFASO. Limitations of sniff nasal pressure in patients with severe respiratory muscle weakness. J
Neurol Neurosurg Psychiatry 2003; 74: 1685-1687.
51
T. SHARSHAR, E. ROSS, N. HOPKINSON, M. DAYER, A. NICKOL, T. SIMILOWSKI, F.
LOFASO, J. MOXHAM, M. POLKEY. Effect of voluntary facilitation on the diaphragmatic response
to transcranial magnetic stimulation. Journal Applied Physiology 2003; 95: 26-34.
52
T SHARSHAR, G DESMARAIS, M POLKEY, B LOUIS, G MACADOU, JC RAPHAËL, D
ISABEY, F LOFASO. Transdiaphragmatic pressure control of airway pressure support in healthy
subjects. Am J Resp Crit Care Med 2003; 168: 760-769.
53
T SHARSHAR, A BLANCHARD, M PAILLARD, JC RAPHAËL, P GAJDOS ET D
ANNANE. Circulating vasopressin levels in septic shock. Crit Care Med 2003; 31: 1752-1758.
54
J. GONZALEZ, T. SHARSHAR, K. CHADDA, N. HART, F. LOFASO, J.C. RAPHAËL. Air
Leaks during Mechanical Ventilation as a Cause of Hypercapnia in Neuromuscular Disorders.
Intensive Care Med 2003; 29: 596-602.
55
T SHARSHAR, S CHEVRET, F BOURDAIN, JC RAPHAËL FOR THE FRENCH
COOPERATIVE GROUP ON PLASMA EXCHANGE IN GUILLAIN-BARRÉ SYNDROME. Early
Predictors of Mechanical Ventilation in Guillain-Barré Syndrome. Crit Care Med 2002; 31: 278-283.
56
M.C. DURAND, F. LOFASO, J.P LEFAUCHEUR, S. CHEVRET, J.C. RAPHAËL, T.
SHARSHAR. Electrophysiology to Predict Mechanical Ventilation in Guillain-Barré Syndrome. Eur
J Neurol. 2003; 10 : 39-44.
57
D. ORLIKOWSKI, B. CHAZAUD, A. PLONQUET, F. PORON, T. SHARSHAR, J.C.
RAPHAËL, R.K. GHERADI, A. CREANGE. Monocytes chemoattractant protein1 and chemokine
receptor CCR2 production in Guillain-Barré (GBS) and experimental autoimmune neuritis. J
Neuroimmunol 2003; 134: 118-127.
58
B. DE JONGHE, T. SHARSHAR, J.P. LEFAUCHEUR, J. AUHTIER, I. DURANDZALESKI, M. BOUSSARSAR, C. CERF, E. RENAUD, S. BASTUJI-GARIN FOR THE GRENER
(GROUPE DE REFLEXION ET D’ETUDE DES NEUROMYOPATHIES EN REANIMATION).
ICU Acquired Paralysis: A prospective multicentric study. JAMA 2002; 288: 2858-2867.
59
T SHARSHAR, J-P LEFAUCHEUR, M-C DURAND, F LOFASO, J-C RAPHAËL, R.K.
GHERARDI, A. CRÉANGE. Circulating Matrix Metalloproteinase MMP-9 Correlates with
Electrophysiological Abnormalities in Guillain-Barré Syndrome. Neurology 2002; 59: 1649-1651.
60
T SHARSHAR, F GRAY, A DORANDEU, F BOURDAIN, F BRION, T EREAU, JC
RAPHAËL, P GAJDOS, D ANNANE. Multifocal necrotizing leukoencephalopathy: a new
mechanism of brain damages in septic shock involving pro-inflammatory cytokines. Crit Care Med
2002; 30: 2371-2375.
61
T SHARSHAR, R CARLIER, A BLANCHARD, A FEYDY, F GRAY, M PAILLARD, JC
RAPHAËL, P GAJDOS, D ANNANE. Depletion of neurohypophyseal content of vasopressin in
septic shock. Crit Care Med. 2002; 30: 497-500.
62
A CRÉANGE, B CHAZAUD, A PLONQUET, T SHARSHAR, F PORON, C SONNET, JC
RAPHAËL, RK GHERARDI. IFN-beta decreases adhesion and transmigration capacities of
lymphocytes in Guillain-Barré Syndrome. Neurology. 2001; 57: 1704-1706.
63
D ANNANE, T SHARSHAR, M KORACH, I JARRIN, J-P FOUILLOT, J-C RAPHAËL, P
GAJDOS. Assessment of sympathovagal balance in critically ill adults: an early diagnostic test for
sepsis. Crit Care Med. 2001; 29: 1380-1385.
64
A CRÉANGE, B CHAZAUD, T SHARSHAR, PLANCHENAULT, JC RAPHAËL, R
GHERARDI. Inhibition of the adhesion step of the leukodiapedesis: a critical event in the recovery of
Guillain-Barré syndrome associated with accumulation of proteotically active lymphocytes in blood. J
Neuroimmunol. 2001, 114: 188-196.
65
T SHARSHAR, S CHEVRET, M MAZIGHI, P CHILLET, CL BEREOTTA, M HOUFANI,
G HUBERFELD, P GAJDOS. Validity and reliability of two muscular scores, commonly used as
endpoints in treatment of myasthenia gravis. Journal of Neurology. 2000; 247: 286-290.
66
A CRÉANGE, T SHARSHAR, PLANCHENAULT, JC RAPHAËL, R GHERARDI. Matrix
metalloproteinase-9 is increased and correlates with severity in GBS. Neurology. 1999; 53: 16831691.
67
D. ANNANE, F. TRABOLD, T. SHARSHAR, I. JARRIN, A.S. BLANC, J.C. RAPHAËL, P.
GAJDOS. Inappropriate sympathetic activation at onset of septic shock. A spectral analysis approach.
Am J Respir Crit Care Med. 1999; 160: 458-465.
68
B. DE JONGHE, D. COOK, T. SHARSHAR, J.P. LEFAUCHEUR, J. CARLET, H. OUTIN.
Acquired neuromuscular disorders in critically ill patients. A systematic review. Intensive Car Med.
1998; 24: 1242-1250.
69
T. SHARSHAR, S. LACROIX-DESMAZE, L. MOUTHON, S. KAVERI, P. GAJDOS, M.D.
KAZATCHKINE. Selective Impairment of serum antibody repertoires toward muscle and thymus in
patients with seropositive and seronegative myasthenia gravis. Eur J Immunol. 1998; 28: 2344-2354.
70
T. SHARSHAR, C. LAMY, J.L. MAS. Incidence and causes of stroke during pregnancy and
puerperium. A study in public hospitals of Ile de France. Stroke. 1995; 26: 930-936.
CASE REPORT
1
S DENIZ, C OPPENHEIM, S LEHÉRICY, T SHARSHAR, T LAHAM, B MARRO, M
SAHEL, Y SAMSON, D DORMONT, C MARSAULT. Diffusion-weighted magnetic resonance
imaging in a case of methanol intoxication. Neurotoxicity. 2000; 21:405-408.
2
T SHARSHAR, I AURIANT, A DORANDEU, M SAGHATCHIAN, L BÉLEC, B
BENYAHIA, JC RAPHAËL, P GAJDOS, J-Y DELATTRE, F GRAY. Association of herpes simplex
virus encephalitis and paraneoplastic encephalitis - A clinico-pathological study. Ann Pathol. 2000;
20: 249-252.
REVIEWS (in peer-reviewed journals; n=25)
1
2
3
4
SONNEVILLE R, VANHOREBEEK I, DEN HERTOG HM, CHRÉTIEN F, ANNANE
D,SHARSHAR T, VAN DEN BERGHE G. Critical illness-induced dysglycemia and the
brain. Intensive Care Med. 2015; 41192-202
ANNANE D, SHARSHAR T. Cognitive decline after sepsis. Lancet Respir Med. 2015
3:61-69
ADAM N, KANDELMAN S, MANTZ J, CHRÉTIEN F, SHARSHAR T.Sepsis-induced
brain dysfunction. Expert Rev Anti Infect Ther. 2013 11(2):211-21.
BOZZA FA, D'AVILA JC, RITTER C, SONNEVILLE R, SHARSHAR T, DAL-PIZZOL F.
Bioenergetics, mitochondrial dysfunction, and oxidative stress in the pathophysiology
of septic encephalopathy. Shock. 2013 May;39 Suppl 1:10-6.
5
6
7
8
9
SONNEVILLE R, VERDONK F, RAUTURIER C, KLEIN IF, WOLFF M, ANNANE D,
CHRETIEN F,SHARSHAR T. Understanding brain dysfunction in sepsis. Ann
Intensive Care. 2013 May 29;3(1):15. doi: 10.1186/2110-5820-3-15.
N STOCCHETTI, PL ROUX, P VESPA, M ODDO, G CITERIO G, PJ ANDREWS,
RD STEVENS, T SHARSHAR, FS TACCONE, JL VINCENT. Clinical review:
Neuromonitoring - an update. Crit Care. 201317:201.
E IACOBONE, J BAILLY-SALIN, A POLITO, D FRIEDMAN, RD STEVENS, T
SHARSHAR Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med.
2009
B DE JONGHE, JC LACHERADE, T SHARSHAR, H OUTIN. Intensive care unit-acquired
weakness: risk factors and prevention. Crit Care Med. 2009
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
RD STEVENS, SA MARSHALL, DR CORNBLATH, A HOKE, DM NEEDHAM,B DE
JONGHE, NA ALI, T SHARSHAR. A framework for diagnosing and classifying intensive
care unit-acquired weakness. Crit Care Med. 2009
N AKROUT, T SHARSHAR, D ANNANE Mechanisms of brain signaling during sepsis.
Curr Neuropharmacol. 2009
T. SHARSHAR, D. ANNANE. Endocrine effects of vasopressin in critically ill patients. Best
Pract Res Clin Anaesthesiol 2008; 22: 265-73.
IK. HART, T. SHARSHAR, S. SATHASIVAM. Immunosuppressant drugs for myasthenia
gravis. J Neurol Neurosurg Psychiatry. 2009; 80:5-6
B. DE JONGHE, JC. LACHERADE, MC. DURAND, T. SHARSHAR. Critical illness
neuromuscular syndromes. Neurol Clin. 2008 26: 507-20
S. SIAMI, D. ANNANE, T. SHARSHAR. The encephalopathy in sepsis. Crit Care Clin
2008; 24: 55-69
B. DE JONGHE, J.C. LACHERADE, M.C. DURAND, T. SHARSHAR. Critical illness
neuromuscular syndromes. Crit Care Clin 2007; 23: 55-69.
I.K. HART, S. SATHASIVAM, T. SHARSHAR. Immunosuppressive agents for myasthenia
gravis. Cochrane Database Syst Rev. 2007; 4:CD005224.
M. EBERSOLDT, T. SHARSHAR, D. ANNANE. Sepsis-associated delirium. Intensive Care
Med. 200733: 941-50.
J. ABOAB, O. NARDI, D. LIPINER, T. SHARSHAR, D. ANNANE. Emerging drugs for the
treatment of sepsis. Expert Opin Emerg Drugs. 2006; 11: 7-22.
T. SHARSHAR, N. HOPKINSON, D. ORLIKOWSKI, D. ANNANE. Science review: The
brain in sepsis--culprit and victim. Crit Care 2005; 9: 37-44.
D. ORLIKOWSKI, H. PRIGENT, T. SHARSHAR, J.C. RAPHAEL. Respiratory dysfunction
in Guillain-Barre Syndrome. Neurocrit Care. 2004;1(4):415-22.
T. SHARSHAR, N. HOPKINSON, D. ORLIKOWSKI, D. ANNANE. Science review: The
brain in sepsis--culprit and victim. Crit Care. 2005 Feb;9(1):37-44.
D. ORLIKOWSKI, T. SHARSHAR, D. ANNANE. Brain in sepsis. Advance in sepsis. (in
Press).
JC RAPHAËL, S CHEVRET, I AURIANT, T SHARSHAR, J BOUGET, F BOLGERT.
Treatment of the adult Guillain-Barre syndrome: indications for plasma exchange. Transfu
Sci. 1999, 20: 53-6
T SHARSHAR, S KAVERI, M KAZATCHKINE. Mechanisms of action of intravenous
immunoglobulin (IVIg) in autoimmune and neuromuscular diseases. Electroencephalogr
Clin Neurophysiol Suppl. 19
CONGRES
Nationaux: SRLF (2003_2015)
Internationaux: ESICM (2008-2015) et ISICEM (2007-2013, 2015)
Congrès de la société scandinave de réanimation (2014), de la British Thoracic Society (2013,
2014), de la société allemande de Neuroréanimation (2014 et 2015).