"In contemporary natural sciences, facts are increasingly subordinated to the possibility of measurement, in the broad sense of that term. The natural sciences display a resistance to any observation which cannot be fitted into a system of measurement." [Perelman, 1969 #27] (p. 102) In EBM, "evidence" is treated as a prescriptive term. "Here lies the whole problem of formalism: either formalism provides a system which is isolated not merely from its applications, but even from the living thought which must understand and manipulate it, that is, integrate it into preexistent mental structures; or it will have to be interpreted and will effect identification which can be ascribed to quasi-logical argumentation. Even if these identifications are not contested during a given period of scientific evolution, it would be dangerous for ulterior progress of thought to regard them as necessary and grant them the selfevidence on attributes to assertions which are no longer open to discussion." (p. 212)[Perelman, 1969 #27] For each type of healthcare issue (diagnosis, prognosis, therapy, assessing harm), Sackett et al are coming up with statements of conditions that must be met in order for evidence to be valid…their choice of definition of "valid evidence." Is there a tension between the way that Sackett is defining "valid evidence" and the way that readers will define these same words as they are understood in the tradition of the language? Will readers be resistant to Sackett's definition of "valid evidence"? "…the use of definition in argumentation implies the possibility of several definitions, borrowed from common usage or created by the writer, among which a choice must be made….related terms themselves are constantly interacting, not only with a set of other terms in the same language or in other languages which can be related to the original, but also with the totality of other possible definitions of the same term. These interactions cannot be eliminated; generally, they are even essential to the significance of the reasoning. However, once the choices I made, whether it be presented as self-evident or whether it be supported by arguments, the definition which is used is regarded as an expression of an identity, indeed as the only satisfactory one under the circumstances, and the equivalent terms, detached in a sense from their ties and their background, can be considered as logical substitutes for each other." (p. 214) [Perelman, 1969 #27]