CURRICULUM VITAE
Nurit Rosenberg, Ph.D
Personal
Born: November 7, 1955 in Dgania, Israel
Marital status:
Married, 3 children
Institute of Thrombosis & Hemostasis
Sheba Medical Center
Tel Hashomer 52621
Israel
Tel: +972-3-5302105 ext 2
Fax: +972-3-5351568
Email: Nuritros@sheba.health.gov.il
Education – Academic degrees
1975 – 1978
B.Sc. (with distinction)
The Hebrew University of Jerusalem,
Microbiology and Phytopathology
1978 – 1980
M.Sc (with distinction)
The Hebrew University of Jerusalem,
Genetics
1980
Certificate of teaching in Biology
Hebrew University of Jerusalem, Israel
1985 – 1989
Ph.D - The Hebrew University of Jerusalem
Biotechnology. Thesis: Nucleic acids introduction using
liposome and other means.
1990 – 1993
Postdoctoral fellowship
Weizmann Institute of Science, Rehovot, Israel.
Molecular and cellular biology of storage proteins
2009-2012
B.A. (with distinction)
The Open University
Psychology
Academic and Professional Experience
1979 – 1980
Volcani Center, The Agricultural Research Organization, Bet-Dagan,
Israel. Department of Flowers and Ornamental plants.
Research assistant.
2
1985 – 1989
The Otto Warburg Center for Biotechnology, Rehovot.
Research Assistance.
1990 – 1993
Weizmann Institute of Science, Rehovot, Israel.
Genetics and Biochemistry.
Research Assistance.
Institute of Thrombosis and Hemostasis, Department of Hematology,
Sheba Medical Center, Tel-Hashomer.
Head of molecular biology.
1993 – 2003
2003
2009
Institute of Thrombosis and Hemostasis, Department of Hematology
& Amalia Biron research Institute of Thrombosis and Hemostasis,
Sheba Medical Center, Tel-Hashomer.
Deputy of laboratory manager
Senior lecturer, Hematology, Sackler Faculty of Medicine, ,
Tel-Aviv University, Israel
TEACHING EXPERIENCE
1979 – 1980
The Hebrew University of Jerusalem, Rehovot, Israel
Genetics for advanced students
Faculty of Agriculture.
Lab. Instructor
1982 – 1984
The Hebrew University of Jerusalem, Rehovot, Israel
Plant diseases, Control of plant disease
Faculty of Agriculture.
Lab. Instructor
1985 – 1989
The Hebrew University of Jerusalem, Rehovot, Israel
Plant Tissue Culture and Plant Propagation.
Faculty of Agriculture.
Lab. Instructor and Teaching Assistant
1996 - 1999
Tel-Aviv University, Israel
Clinical, molecular and genetic aspect of congenital disorders in
thrombosis and Hemostasis
Sackler School of Medicine
Guest teacher
2003 - 2010
Tel-Aviv University, Israel
The molecular and biochemical bases of the thrombosis and
Hemostasis.
Sackler School of Medicine
2005
Ministry of Health, The Bella and Joseph Lewenfisz, National
Training Center.
Human Genetics.
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3
Guest teacher
2010
2013
Sackler School of Medicine, Tel-Aviv University, Israel
Management of Medical Laboratories. Guest teacher
Sackler School of Medicine, Tel-Aviv University, Israel
Hematology for medical laborants.
Publications
1. Gad AE, Elyashiv G, Rosenberg N. The induction of large unilamellar vesicles
fusion by cationic polypeptide: the effects of mannitol, size, charge density and
hydrophobicity of the cationic polypeptides. Biochem Biophys ActaBiomembrane 860:314-324, 1986.
2. Rosenberg N, Gad AE, Altman A, Navot N, Czosnek H. Liposome-mediated
introduction of the chloramphenicol acetyl transferase (CAT) gene and its
expression in tobacco protoplasts. Plant Mol Biol 10:185-191, 1988.
3. Gad AE, Lubitz-Omero C, Rosenberg N, Altman A. Changes in the integrity of
large unilamellar vesicles due to their interaction with tobacco cell suspensions.
Plant Cell Rep 7:341-343, 1988.
4. Rosenberg N, Shimoni Y, Altschuler Y, Levanony H, Volokita M, Galili G. A
wheat (Triticum aestivum L.) -gliadin accumulates in dense protein bodies within
the endoplasmic reticulum of yeast. Plant Physiol 102:61-69, 1993.
5. Altschuler A, Rosenberg N, Harel R, Galili G. The N- and C-terminal regions
regulate the transport of wheat -gliadin through the endoplasmic reticulum in
Xenopus oocytes. Plant Cell 5:443-450, 1993.
6. Shani N. Rosenberg N, Kasarda DD, Galili G. Mechanisms of assembly of
wheat high molecular wheat glutenins inferred from expression of wild-type and
mutant subunits in transgenic tobacco. J Biol Chem 269:8924-8930, 1994.
7. Peretz H, Rosenberg N, Usher S, Graff E, Newman PJ, Coller BS, Seligsohn
U. Glanzmann thrombasthenia associated with deletion-insertion and alternative
splicing in glycoprotein IIb gene. Blood 85:414-420, 1995.
8. Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B,
Seligsohn U. Coexistence of hereditary homocystinuria and factor V Leiden –
effect on thrombosis. N Engl J Med 334:763-768, 1996.
9. Zivelin A, Rosenberg N, Peretz H, Amit Y, Kornbrot N, Seligsohn U. Improved
method for genotyping apolipoprotein E polymorphisms by a PCR-based assay
simultaneously utilizing two distinct restriction enzymes. Clin Chem 43:16571659, 1997.
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10. Rosenberg N, Yatuv R, Orion Y, Zivelin A, Dardik R, Peretz H, Seligsohn U.
Glanzmann thrombasthenia caused by an 11.2 kb deletion in the GPIIIa (3) is a
second mutation in Iraqi-Jews that stemmed from a distinct founder. Blood
89:3654-3662, 1997.
11. Dardik R, Kaufmann Y, Savion N, Rosenberg N, Shekman B, Varon D.
Platelets mediate tumor cell adhesion to the subendothlium under flow conditions:
involvement of platelet GPIIbInt J Cancer
70:201-207, 1997.
12. Yatuv R, Rosenberg N, Dardik R, Brenner B, Seligsohn U. Glanzmann
thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction
mutation in the glycoprotein IIb. Blood Coagul Fibrinolysis 9:285-298, 1998.
13. Rosenberg N, Dardik R, Rosenthal E, Zivelin A, Seligsohn U. Mutations in the
IIb and 3 genes that cause Glanzmann thrombasthenia can be distinguished by
a simple procedure using transformed B-lymphocytes. Thromb Haemost 79:244248, 1998.
(A figure of this article was chosen to be presented on the cover).
14. Zivelin A, Rosenberg N, Fair S, Kornbrot N, Peretz H, Mannhalter C, Horollou
MH, Seligsohn U. A single genetic origin for the common prothrombotic G20210A
polymorphism in prothrombin gene. Blood 92:1119-1124, 1998.
15. Salomon O, Moisseiev J, Rosenberg N, Vidne O, Yassur I, Zivelin A, Treister
G, Steinberg DM, Seligsohn U. Analysis of genetic polymorphisms related to
thrombosis and other risk factors in patients with retinal vein occlusion. Blood
Coagul Fibrinolysis 9:617-622, 1998.
16. Inbal A, Freimark D, Modan B, Chetrit A, Matetzky S. Rosenberg N, Dardik R,
Baron Z, Seligsohn U. Synergistic effects of prothrombotic polymorphisms and
atherogenic factors on the risk of myocardial infarction in young males. Blood
93:2186-2190, 1999. IF-10.37, Hematology 2/61.
17. Salomon O, Apter S, Shaham D, Hiller N, Bar-Ziv J, Itzchak Y, Gitel S,
Rosenberg N, Strauss S, Kaufman N, Seligsohn U. Risk factors associated with
postpartum ovarian vein thrombosis. Thromb Haemost 82:1015-1019, 1999.
18. Salomon O, Steinberg DM, Zivelin A, Gitel S, Dardik R, Rosenberg N,
Berliner S, Inbal A, Many A, Lubetsky A, Varon D, Martinowitz U, Seligsohn U.
Single and combined prothrombotic factors in patients with idiopathic venous
thromboembolism: prevalence and risk assessment. Arterioscl. Thromb Vasc
Biol 19:511-518, 1999.
19. Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiv J, Rosenberg
N, Yassur I, Vidne O, Zivelin A, Gitel S, Davidson J, Ravid B, Seligsohn U.
Analysis of prothrombotic and vascular risk factors in patients with nonarteritic
anterior ischemic optic neuropathy. Ophthalmology 106:739-74, 1999.
Cited in: The Year Book of Ophthalmology 2000. Wilson RP edt.,
pp 213-214.
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20. Hayek S, Kenet G, Lubetsky A, Rosenberg N, Gitel S, Weintroub S. Does
thrombophilia play an aetiological role in Legg-Calve-Perthes disease? J Bone
Joint Surg [Br] 81:687- 690, 1999.
21. Kenet G, Sadetzki S, Murad H, Martinowitz U, Rosenberg N, Gitel S, Rechavi
G, Inbal A. Factor V Leiden and anti phospholipid antibodies are significant risk
factors for ischemic stroke in children. Stroke 31:1283-1288, 2000.
22. Salomon O, Dardik R, Steinberg DM, Kurtz S, Rosenberg N, Moisseeiev J,
Huna-Baron R. The role of angiotensin converting enzyme and angiotensin II type
1 receptor gene polymorphisms in patients with nonarteritic anterior ischemic
optic neuropathy. Ophthalmology 107:1717-1720, 2000.
23. Salomon O, Rosenberg N, Zivelin A, Steinberg DM, Kornbrot N, Dardik R,
Inbal
A,
Seligsohn
U.
Methionine
synthase
A2756G
and
methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors
for idiopathic venous thromboembolism. Hematology J 2:38-41, 2001.
24. Yatuv R, Rosenberg N, Zivelin A, Peretz H, Trakhtenbrot L, Seligsohn U.
Identification of a region in glycoprotein (GP)IIIa involved in subunit association
with GPIIb – further lessons from Iraqi-Jewish Glanzmann thrombasthenia. Blood
98:1063-1069, 2001.
25. Mor-Cohen R, Zivelin A, Rosenberg N, Shani M, Muallem S, Seligsohn U.
Identification and functional analysis of two novel mutations in the multi-drug
resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrom. J Biol
Chem 276:36923-30, 2001.
26. Salomon O, Huna-Baron R, Moisseiev J, Rosenberg N, Rubovitz A,
Steinberg DM, Davidson J, Sela BA, Seligsohn U. Thrombophilia as a cause for
central and branch retinal artery occlusion in patients without an apparent embolic
source. Eye 15:511-514, 2001.
27. Striefler JY, Rosenberg N, Chetrit A, Eskaraev R, Sela BA, Dardik R, Zivelin
A, Ravid B, Davidson J, Seligsohn U, Inbal A. Cerebrovascular events in patients
with significant stenosis of the carotid artery are associated with
hyperhomocyteinemia and platelet antigen-1 (Leu33Pro) polymorphism. Stroke
32:2753-2758, 2001.
28. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E,
Seligsohn U. the frequent 5,10-methylenetetrahydrofolate reductase C677T
polymorphism is associated with a common haplotype in Caucasians, Japanese
and Africans. Am J Hum Genet 70:758-762, 2002.
29. Zivelin A, Bauduer F, Ducout L, Peretz H, Rosenberg N, Yatuv R, Seligsohn
U. Factor XI deficiency in French Basques is predominantly Caused by ancestral
C38R mutation in the factor XI gene. Blood 99:2448-2454, 2002..
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30. Rosenberg N, Zivelin A, Chetrit A, Dardik R, Kornbrot N, Freimark D, Inbal A.
Effects of platelet membrane glycoprotein polymorphisms on the risk of
myocardial infarction in young males. Israel Med Assoc 4:411-414, 2002.
31. Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A.
Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss.
Hum Reprod 17:1633-1637, 2002.
32. Rosenberg N, Yatuv R, Sobolev V, Peretz H, Zivelin A, Seligsohn U. Major
mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with
Glanzmann thrombasthenia enable GPIIb/IIIa complex formation but abolish its
transport from the endoplasmic reticulum to the Golgi apparatus. Blood 101:
4808-4815, 2003..
33. Salomon O, Steinberg DM, Dardik R, Rosenberg N, Zivelin A, Tamarin I,
Ravid B, Berliner S, Seligsohn U. Inherited factor XI deficiency confers no
protection against acute myocardial infarction. J Thromb Haemost 1:658-661 (in
focus), 2003..
34. Kenet G, Hayek S, Mor M, Lubetsky A, Miller L, Rosenberg N, Mosheiff R,
Itzchaki M, Elstein D, Wientroub S, Zimran A. The 1226G (N370S) Gaucher
mutation among patients with Legg-Calve-Perthes disease. Blood Cells Mol Dis
31:72-74, 2003. IF-2.678, Hematology 27/61
35. Horton MA, Massey HM, Rosenberg N, Nicholls B, Seligsohn U, Flanagan
AM. Upregulation of osteoclast 21 integrin compensates for lack of v3
vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia. Brit J
Haematol 122:950-957, 2003.
36. Kenet G, Maayan A, Rosenberg N, Sela BA, Mazkeret R, Ifrah A, Kunit J.
Thrombophilia does not increase risk for neonatal complications in preterm
infants. Thomb Hemost 90:823-828, 2003.
37. Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, BrokSimoni F, Gadoth N, Sela BA, Seligsohn U. High prevalence of vitamin B12 and
folic acid in elderly subjects in Israel. Brit J Haematol 123: 696-701, 2003.
38. Salomon O, Rosenberg N*, Steinberg DM, Huna-Baron R, Moisseiev J,
Dardik R, Goldan O, Kurtz S, Ifrah A, Seligsohn U. Nonarteritic anterior ischemic
optic neuropathy is associated with a specific platelet polymorphism located on
the glycoprotein Ib gene. Ophtalmology 111:184-188, 2004.
*The first two authors contributed equally to this study.
39. Segal A, Zivelin A, Rosenberg N, Ginsburg O, Shpilberg O, Seligsohn U. A
mutation in LMAN1 (ERGIC-53) causing combined factors V and VIII deficiency is
prevalent in Jews originating from the island of Djerba in Tunis. Blood Coagul
Fibrinolysis 15: 99-102, 2004.
40. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livne A,
Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the
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leading cause of thrombosis in Behcet's disease. Ann Rheum Dis 63:1445-9,
2004
41. Rosenberg N, Landau M, Luboshitz J, Rechavi G, Seligsohn U. A novel
Phe171Cys mutation in integrin IIb causes Glanzmann thrombasthenia by
abrogating IIb3 complex formation. J Thromb Haemost 2:1167-1175, 2004.
42. Vysokovsky A, Saxema R, Landau M, Zivelin A, Eskaraev R, Rosenberg N,
Seligsohn U, Inbal I. Seven novel mutations in the factor XIII A-subunit gene
causing hereditary factor XIII deficiency in ten unrelated families. J Thromb
Haemost 2:1790-1797, 2004.
43. Fromovich-Amit Y, Zivelin A, Rosenberg N, Tamary H, Landau M, Seligsohn
U. Characterization of mutations causing factor VII deficiency in 61 unrelated
Israeli patients. J Thromb Haemost 2:1774-1781, 2004..
44. Salomon O, Seligsohn U, Steinberg DM, Zalel Y, Lerner A, Rosenberg N,
Pshithizki M, Oren M, Ravid B, Davidson J, Sciff E, Achiron R. The common
prothrombotic factors in nuliparous women do not compromise blood flow in the
feto-maternal circulation and are not associated with preeclampsia or intrauterine
growth restriction. Am J Obstet Gynecol 191:2002-2009, 2004.
45. Mor-Cohen R, Zivelin A, Rosenberg N, Goldberg I, Seligsohn U. A novel
ancestral splicing mutation in the multidrug resistance protein 2 gene causes
Dubin-Johnson syndrome in Ashkenazi Jewish patients. Hepatol Res 31:104111, 2005
46. Losonczy G, Rosenberg N, Kiss C, Kappelmayer J, Vereb G,
Kerenyi A,
Balogh I, Muszbek L. A novel homozygous mutation (1619delC) in GPIIb gene
associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the
synthesis of a truncated GPIIb unable to form complex with GPIIIa. Thromb
Heamost 93:904-909, 2005.
47. Salomon O, Steinberg DM, Pshithizki M, Zalel Y, Lerner A, Rosenberg N,
Achiron R. The influence of protrombotic polymorphisms and obstetrical and
medical variables on the length of secondary postpartum hemorrhage. J
Women's Health 14:306-310, 2005. IF-1.711,
48. Fromovich-Amit Y, Zivelin A, Rosenberg N, Landau M, Rosa JP, Seligsohn
U. Of four mutations in the factor VII gene in Tunisian patients, one novel
mutation (Ser339Phe) in three unrelated families abrogates factor X activation.
Blood Coagul Fibrinolysis 16:369-374, 2005.
49. Rosenberg N, Hauschner H, Peretz H, Mor-Cohen R, Landau M, Shenkman
B, Kenet G, Coller BS, Awidi AA, Seligsohn U. A 13bp deletion in IIb gene is a
founder mutation that predominates in Palestinian Arab patients with Glanzmann
thrombasthenia. J Thromb Haemost 3:2764-2772, 2005..
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50. Vysokovsky A, Rosenberg N*, Dardik R, Seligsohn U, Inbal A. Effect of four
missense mutations in the factor XIII A-subunit gene on protein stability: studies
with recombinant proteins. Blood Coagul Fibrinolysis 17: 125-130, 2006.
*The first two authors contributed equally to this study.
51. Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJR,
MorCohen R, French DL, Mitchell BW, Chandy M, Coller BS, Srivastava A, Seligsohn
U. Molecular Diversity of Glanzmann thrombasthenia in Southern India: New
insights into mRNA splicing and structure-function correlations of αIIbβ3 integrin.
Human Mutation 27:359-369, 2006.
52. Salomon O, Moisseiev J, Vilganski T, Dardik R, Kurtz S, Springer E, Steinberg
DM, Rosenberg N. Role of five platelet membrane glycoprotein polymorphisms in
branch retinal vein occlusion. Blood Coagul Fibrinolysis 17: 485-488, 2006.
53. Rosenberg N, Lalezari S, Landau M, Shenkman B, Seligsohn U, Izraeli S.
Trp207Gly in platelet glycoprotein Ib
connection between the leucine- rich repeat domain and the disulfide loop
structure and causes Bernard-Soulier syndrome. J Thromb Haemost 5: 378-386,
2007..
54. Mor-Cohen R, Zivelin A, Fromovich-Amit Y, Kovalski V, Rosenberg N,
Seligsohn U. Age estimates of ancestral mutations cauing factor VII deficiency
and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with
ancient Jewish migrations. Blood Coagul Fibrinolysis. 18:139-144, 2007.
55. Losonczy G, Rosenberg N, Boda Z, Vereb G, Kappelmayer J, Hauschner H,
Bereczky Z, Muszbek L. Three novel mutations in the glycoprotein IIb gene in a
patient with type II Glanzmann thrombasthenia. Haematologica 92:698-701,
2007.
56. Haran MZ, Lichman I, Berebbi A, Weinmanbn E, Rosenberg N. Unbalanced
protein S deficiency due to warfarin treatment as a possible cause for thrombosis.
Brit J Hematol 139:310-1, 2007.
57. Mor-Cohen R, Rosenberg N*, Peretz H, Landau M, Coller BS, Awidi A,
Seligsohn U. Disulfide bond disruption by a Cys549Arg mutation in the 3 gene in
6 Jordanian families with Glanzmann thrombasthenia causes diminished
production of constitutively active IIb3. Thromb Heamost 98:1257-65, 2007.
*The first two authors contributed equally to this study.
58. Mor-Cohen R, Rosenberg N, Landau M, Lahav J, and Seligsohn U. Specific
cysteines in 3 are involved in disulfide bond exchange-dependent and independent activation of IIb3. J. Biol. Chem 283:19235-44, 2008.
59. Kenet G, Ezra E, Wientroub S, Steinberg DM, Rosenberg N, Waldman D,
Hayek S. Legg Calve Perthes disease- in search of genetic associations: collagen
mutations, Gaucher disease and thrombophiliaJ Bone Joint Surg [Br] 90-B:
1507-11, 2008.
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60. Landau D, Rosenberg N, Zivelin A, Starretz-Hacham O, Kapelushnik Y.
Familial factor VII deficiency with fetal and neonatal fatal cerebral hemorrhage
associated with homozygosis to Gly180Arg mutation. Hemophilia 2009 15:774-8,
2009.,
61. Zucker M, Zivelin A, Landau M, Rosenberg N, Seligsohn U. Three residues at
the interface of factor XI monomers augment covalent dimerization of factor XI. J
Thromb Haemost 7: 970-5, 2009..
62. Manaster Y, Shenkman B, Rosenberg N, Savion N. Allicin and disulfiram
enhance platelet integrin IIb-3 – fibrinogen binding. Thromb. Res. 124:477-82.
2009,
63. Hauschner H, Landau M, Seligsohn U, Rosenberg N. A unique interaction
between αIIb and β3 in the head region is essential for outside-in signaling related
functions of αIIbβ3 integrin. Blood 115:4542-50, 2010
64. Landau M, Rosenberg N. Molecular Insight into Human Platelet Antigens:
Structural and evolutionary conservation analyses offer new perspective to
immunogenic disorders. Transfusion 51:558-569, 2010
65. Mansour W, Einav Y, Hauschner H, Koren A, Seligsohn U. Rosenberg N
An IIb mutation in patients with Glanzmann thrombasthenia located in the Nterminus of blade 1 of the -propeller [Asn2Asp ] disrupts a calcium binding site in
blade 6 . J Thromb Haemost, 9:192-200, 2011
66. Zucker M, Rosenberg N, Peretz H, GreenD, Bauduer F, Zivelin A, Seligsohn
U. Point mutations regarded as missense mutations cause splicing defects in the
factor XI gene J Thromb Haemost 9:1977-84, 2011
Commentary by Duga S. Asselta R. Mutations in disguise. J Thromb Haemost
9:1973-6
67. Hauschner H, Mor-Cohen R, Seligsohn U, Rosenberg N.
A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia
by abrogating transition of αIIbβ3 to an active state. J Thromb Haemost 10:289297, 2012
68. Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W,
Averbukh Y, Seligsohn U. Integrin unique disulfide bonds in the EGF domains of β3
affect the structure and function of αIIbβ3 and αvβ3 integrins in a different manner. J
Biol Chem 287:8879-91, 2012
69. Loewenthal R, Rosenberg N*, Kalt R, Dardik R, Landau M, Yahalom V,
Avishai O, Frenkel O, Gazit E, Steinberg DM, Lipitz S, Salomon O.
Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a
potential predictor of neonatal alloimmune thrombocytopenia (NAIT).
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Transfusion in press, 2012 *The first two authors contributed equally to this
study.
70. Maayan-Metzger A, Lubetsky A, Kuint J, Rosenberg N, Simchen MJ,
Kuperman A, Strauss T, Sela BA, Kenet G. The Impact of Genetic and
Environmental Factors on Homocysteine Levels in Preterm Neonates. Pediatr
Blood Cancer 60:659-662, 2013
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