Chromosomes – Genes – DNA Instructions and Blue Prints to Who We Are Organism ← Cell ← Nucleus ← Chromosomes ← Genes ← DNA http://gs lc.genetics.utah.edu Chromosomes – In the nucleus of each ____________, the DNA is packed into thread-like structures called chromosomes. The chromosomes contain genetic information that controls ________. Figure 1.4: Diagram of a human cell Each chromosome is made up of ___________ tightly coiled many times around proteins. Humans have _________ chromosomes that come in _________ pairs. A mother passes 23 chromosomes to her child through her _________ and a father passes _______________ chromosomes through his sperm. DNA works by ___________________ information chemically in its structure. The chemical information contains instructions for the body to create ______________. In more detail it provides the instructions to make proteins which allows for the ___________________ and development of an organism. Also it can make _______________ of itself that has the exact same instructions to build a new organism. DNA (Deoxyribonucleic Acid) – When organisms reproduce, _________________ are passed from parent to parent to ____________________. These traits are carried in ___________, the genetic material found in ____________________ located in the cell’s nucleus. ______________ acts like a blueprint for the cells of an organism, instructing them how to put together materials to produce certain ____________. DNA is a large molecule with a shape similar to a twisted _____________ (double helix). The ends are joined to form a continuous loop, like a rubber band. Rungs of ladder base pairs The DNA’s twisted-zipper or ladder shape is because of the ________________ called nucleotides. A _________________ is a molecule made up of a nitrogen base, a sugar, and a phosphate group. The sides or backbone of the zipper or ladder are made up of ________________and______________. The rungs or steps of the zipper or ladder are made up of _________________ called nitrogen bases. The rungs or steps of the zipper or ladder are made up of four nitrogen bases called adenine, thymine, guanine, and cytosine. These bases always pair up so that adenine is joined with a thymine (_________) and cytosine is joined with guanine (_____________). It is the arrangement of these nitrogen base pairs that determine whether the organism is a rose, hawk, fly, or human. Only 2 percent of your DNA determines everything from your eye ______________ to what diseases you might be easy for you to get. The other 98% (junk DNA) is largely a mystery to what the job of these DNA molecules do. The total sum of all your hereditary information is called the genome. There are a total of approximately 3 billion __________ pairs in the human genome. For humans 99.9% of the base pairs are the same and 0.1% is different. This 0.1 percent makes every person a little bit ___________________. An important property of DNA is that it can replicate, or make ______________ of itself. This is important when cells divide because each new cell needs to have an exact copy of ________________ present in the old cell. http://teach.genetics.utah.edu/content/ Genes – A gene is a section on a chromosome that has genetic information in the form of _________ for one _________. The DNA making up the ________________ is usually coiled up tightly. If we imagine it stretched out, it would look like beads on a string. Each of these beads is called a ____________. Each gene is located at a definite place on the _____________________. Figure 1.3. Chromosomes are like strings of genes Genes, which are made up of_____________, act as __________________ to make or synthesis molecules called proteins. In humans genes vary in size from a few hundred DNA bases to more than 2 million bases. Humans have between 20,000 and 25,000 genes which are located in the chromosomes. Genes control and determine ___________ and direct the production of ________________. Proteins are very important molecules in our______________. They are involved in virtually all cell functions. Each different protein within the body has a specific function or ___________. Some proteins are involved in structural support, while others are involved in bodily movement, or in defense against germs. For an example imagine a cat with white and black fur. The genes in the nuclei of this cat’s cells direct the production or synthesis of _________________ that cause black or white fur to grow on certain parts of the body. Your genes are like switches that turn ______ or _________. Some ______________ turn on, others are always ___________, and still others turn ______ and ___________. An example is the gene that determines neck size. This special gene is carried by many different __________________________. Both a giraffe and mouse have this same gene but in the giraffe it is turned on for a __________________ time than in a mouse. The end result is that the giraffe has a _____________ neck and the mouse has a ________________ neck. Like chromosomes every person has ___________ copies of each gene, one inherited from each __________________. Most genes are the same in all people, but a small number of genes (less than 1 percent of the total) are slightly different between people. Another place in the cell where DNA is found is in very small compartments called mitochondria that are found randomly scattered in the cytoplasm outside the nucleus. The mitochondria are the energy centers of the cell. Mitochondrion contains genes too, although the mitochondria DNA is in one long string of genes and is not arranged as _______________________. “Simplified explanation of how DNA, Genes, and Chromosomes relate to each other.” In simple terms think of the strands of _______ as letters – ATCGGCTAATATCGCGGCGCGCATCGAT The letters combine to form __________. ATCG GCTAAT ATCG CGGCGC GCAT CGAT These words make sentences – (ATCG GCTAAT ATCG.) (CGGCGC GCAT CGAT.) These “sentences” are called____________. Each gene will read the arrangement of the DNA “sentence” in it which will then tell the cell to make a molecule called a_____________. The proteins will tell the cell to perform a certain function or _________. __________________ are efficient storage units for the DNA that is contained in the genes. For humans a chromosome can have hundreds of genes. Each gene will read a different DNA “sentence” to produce a different ____________ to do a different task or_________. https://www.youtube.com/watch?v=_POdWsii7AI show cartoon of dna, structure http://www.pbs.org/wgbh/nova/body/cracking-your-geneticcode.html