Module for Academic Year, 2010/2011
(Semester 2)
1.
New Module Code and Title
BL5216 Genomics and Advanced Genetics
2.
Brief Module Description
(of Publishable Quality for Handbook / Prospectus
/ Bulletin / Websites)
Between 75 – 100 words briefly addressing:
What are the teaching and learning objectives?
What are the major topics covered?
Who are the target students?
Aims and objectives (see Notes for definitions)
(Elaboration of teaching and learning objectives)
The module is directed toward graduates with basic
molecular biology and genetic backgrounds who are
interested in conducting genomics-based research. The
module will also introduce the unique aspects of
different model organisms and approaches to
understand their gene function.
3.
4.
Syllabus
(Elaboration of major topics covered)
Xu Jian (DBS)
Ng Huck Hui (GIS)
Thomas Lufkin (GIS)
Ruan Yijun (GIS)
Lawrence Stanton (GIS)
Robson, Paul (GIS)
25
6
2
8
8
12
5.
Assessment
(Please indicate % breakdown of each CA
component and % for Final Examination)
6.
7.
8.
To be offered in
Cross Listing (if applicable)
Prerequisites (if applicable)
9.
Preclusions (if applicable)
10.
Module Lecturer(s) 2
Name(s)/Department(s):
11.
12.
Modes of Teaching and Learning
(Lectures, regular tests, Q & A, IVLE, problembased learning)
Basic Reading List
Compulsory reading
Aim: The module aims to equip the students with the
latest knowledge on characterizing and understanding
genomes in the broadest sense.
Objectives: Upon completion of the module, the
students will be able to appreciate the strengths and
weaknesses of large scale genomic studies. They will
also be able to apply the modern genetic techniques
across different model organisms.
1. Introduction and overview
2. Post-sequence era (Trends and Technologies)
3. Comparative Genomics
4. Transcriptome analyses
5. Model organisms:
Yeast (budding and fission)
Arabidopsis & rice
C. elegans
Drosophila
Zebrafish / Xenopus / Chick
Mouse / Human
Evolutionary Genomics
Comparative Genomics
6. Genetic analysis: Importance and approaches
Linkage analysis
Affected sibling and relative pair analysis
Epidemiologic association study design
Linkage disequilibrium and association studies.
Tutorials/Assignments:
50%
Laboratories:
nil
Mid-term:
nil
Final Examinations:
nil
Others: Term Paper/Literature Review
50%
Total:
100%
AY2007/2008, Semester 2
NA
Students must have read advanced undergraduate
courses in molecular biology, cell biology and genetics
NA
Xu Jian (DBS)
Thomas Lufkin (GIS), Ruan Yijun (GIS), Robson, Paul
(GIS),Lawrence Stanton (GIS), Ng Huck Hui (GIS)
Lectures, Q & A, problem-based learning, tutorial
assignments, seminars
Nil
Supplementary reading
13.
14.
15.
Maximum Class Size
Modular Credits (MC)
Workload Per Week
(The workload for a 4-MC module must add up
to 10 hours per week. E.g. 2 hours lecture;
1 hour tutorial; 7 hours preparatory work)
“Genetics: From Genes to Genomes” by Hartwell et al.
McGraw Hill Publications. 2000. 1st Edn.
Other review papers and book chapters to be
recommended
50
4MC
Lecture hours per week:
2
Tutorial hours per week:
2
Laboratory hours per week:
0
No. of hours per week for projects, fieldwork, 3
assignments, etc. :
No. of hours per week for preparatory work 3: 3
Total hours per week:
10