Aim for the Top University Project National Central University – " Complex Systems and Plasma Sciences " Principal Investigator: CHEN, Pei-Long I. Analysis and Evaluation of the Key Field (1) Current Achievements and Features Complex systems are composite of many small units which interact through nonlinear interactions and complex feedback loops. The systems thus exhibit spatial structures and dynamical behavior ranging from simple ordering, through complex structures and finally to chaotic states in space and time. Complex systems cover a wide range of fields, including fluids, condensed matters, plasmas, biological systems, as well as social, traffic and financial systems. In the past thirsty years, with the developments of nonlinear dynamics, statistical physics, high speed/high resolution measurements and large scale numerical simulations, complex systems have become a very important cross-discipline research subject, with enormous potential of practical applications. Different complex systems share similar nonlinear interaction and feedback mechanisms, and their composing units have many common characters. For example, by the mechanisms of controls, external random or regular driving, and feedbacks, many complex systems show a range of possible behaviors such as long spatial and temporal correlation, multiscale avalanche, self-organized criticality, chaos, and stochastic resonances. Strong field laser systems which have seen great development in recent years internationally are also important experimental systems for studying problems in complex systems and others. The strong field lasers can perform many leading edge experiments. The spin off of technical development is also valuable to the related industry. Strong electromagnetic fields can probe relativistic plasma nonlinear optics. This is a very new research area. Nonlinear dynamics arising from interaction between light and plasmas elucidate many fundamental mechanisms. Intense laser pulses can create all sorts of light and particle sources to study many important topics. For example, ultrafast hard X rays can resolve reaction dynamics of DNA, RNA, protein, and polymers, providing answers to fundamental life sciences. Ultrafast infrared pulses can resolve motions and energy transfers inside a molecule. Ultrafast THz pulses can probe electric field inside electronic materials, helping the development of new devices. NCU have done excellent researches in complex systems and plasma science and technology, regarded as the best group in Taiwan. The researches in strong field laser, laser plasma, dusty plasma, experimental and theoretical soft matter and biophysics have also been the leading ones in Asia. Some are also world leading. Group members have received many outstanding awards such as Academician, National Chair of MOE, and Outstanding Research Award of NSC. Strong field laser plasma physics team has constructed a 100TW laser with 3 synchronized light beams of 2 different wavelengths. The powers of these beams are 100 TW, 15 TW and 6 TW, with power, wave shape, orientation deviations less than 2%, 5% and 5 Rad respectively. The focused intensity achieved 1020 W/cm2, better than lasers in similar classes. We have demonstrated that our manipulation of instantaneous plasma structures has good application potential in higher harmonics quasi-phase matching, X-ray laser, laser amplification by Raman back scattering, holography, etc. Our X-ray laser is ready for practical applications, with the spectrum intensity at 32.8 nm being higher that 1 the third generation of synchrotron radiation, and peak intensity billion times stronger. Frontier complex systems experimental research focus on various advanced topics in dusty plasma system, non-equilibrium physics, biophysics, soft-matter and nonlinear physics with various significant results published in prestigious journals such as Science, PNAS, Phys. Rev. Lett., Biophys. J, etc. Theoretical Research in Nonlinear Complex Systems focuses on the close interaction and collaborations among theorists and experimentalists, through the establishment of the Center for Mathematics and Theoretical Physics to integrate theoretical science resources and manpower. We have also co-hosted the third phase of the National Center for Theoretical Sciences with TsingHua and ChiaoTung University. (2) Current Leadership Status in Taiwan and Internationally NCU has the leading research team in complex systems and plasma in Taiwan. For example, our 100TW laser system is one of the best five worldwide, the Coulomb crystal observed by the research team leaded by Prof. I in 1994 opened the new field of dusty plasma complex system and his Science paper remained to be the top cited paper for research accomplished in Taiwan. He was elected Academician by Academia Sinica in 2008. Our team achieved various important results in complex systems and drew international attention, for example New York Times had reported on our work in jamming of granular flow in hopper. We have close collaborations with Institute of Atomic & Molecular Science and Institute of Physics in Academia Sinica in areas such as nonlinear physics, biophysics, strong-field physics, with several laboratories set up in our department. The “Complexity & Life” focus group of National Center for Theoretical Sciences is continuously based in our department. (3) Important Contributions to Industry and the Social Development of the Country We anticipate our unique light and particle sources from the 100 TW system can be used in material manipulation and probing, biomedical therapy, nuclear physics, with immense applications in basic science research. This table-top facility is much more convenient as compared to the conventional large-scale light and particle sources. Just like laser, MRI, and synchrotron radiation whose basic sciences were all developed by physicists, we believe the downstream applications of our facilities would have very positive and deep impact to mankind and society. (4) The Major Differences or Breakthroughs enabled by the previous phase of “Plan for Developing Top Universities and Research Centers” We constructed a 100 TW laser system with 4 laser-plasma interaction and 4 downstream application experimental stations. We achieved 300 MeV mono-energetic electron beam, 8 MeV proton beam, free electron laser with energy over 6 keV. This is the foundation of further applications and researches. We have also setup a core experimental facility of biophysics and soft matters, providing advance facility for sample preparation and measurements. The creation of Center for Mathematics and Theoretical Physics provides a cross-discipline platform for the support of collaborations among experimental, theoretical and simulation researches. 2 (5) Description of the Current Status of the Existing Resources in the Research Center and Allocation of All Funding Sources Academia Sinica thematic project provides 3 year funding of NT$27 million to develop strong field laser plasma physics. The PIs have received a total about NT$40 million research grants from National Science Council each year. (6) Analyses of the Current Statuses of Research Centers in the Same Field and Plans for Future Development for the Research Center Strong field laser plasmas research is a very hot topic. The goals are to increase laser intensity, particle energy and X ray characteristics, to probe new physics and applications. Europe has started the Extreme Light Initiative project, planning to build three 50 PW demonstration lasers, and then coupling four 50 PW lasers to produce 200 PW power. Under this high power, strong electromagnetic field in laser lights can produce electron-positron pairs out of vacuum, studying the whole new vacuum structure experienced by electrons. This is a fundamental breakthrough for basic science research. Currently 100 TW to 1 PW international facilities are almost always in the national laboratory level facilities. Only very few university laboratories have 100 TW level lasers. In the following we list a few facilities which have lasers with pulse length less than 100 fs, repetition rate higher than three per minutes, and power between 100 TW and 1PW. Laboratory Laboratorie d’Optique Appliquee, France Forschungszentrum Dresden-Rossendorf, Germany Lawrence-Berkeley National Laboratory, Lasers Optical Accelerator Systems Integrated Studies (LOASIS) program, USA NSF Center for Ultrafast Optical Science (CUOS) at University Of Michigan, USA Power Status Seven research 100TW groups with 43 permanent staffs. 150TW operational since 2008. 150TW Developing PW laser. Seven PI and 3 technical staffs. Research Topics Ultrafast intense laser. X-ray sources. Particle sources. Plasma physics. Laser-ion acceleration with application in radiation oncology. Laser-electron acceleration. Computer simulation. LOASIS program has 8 scientific 100TW staffs, 6 technical staffs, 5 postdoctoral researchers. Laser-electron acceleration. Laser-ion acceleration. Radiation from laser-plasma interaction theory and simulation. CUOS has 8 research groups, in which the 300TW high field science group has 9 scientific faculties. Laser-electron acceleration. Laser-ion acceleration. Radiation from laser-plasma interaction. Neutron production theory and simulation. Our strong field laser team is an university level laboratory with only three PI and three postdocs. We cannot compete with national laboratory on pure laser power. However, by continue improvement of laser quality, we can still maintain a world leader in research of fundamental mechanism and down stream applications. Especially there are excellent research groups on complex system in NCU for collaborations, with very good researches in dusty plasma, granular materials, and complex fluids. Recently we also have very active 3 research in biophysics such as neutral network, cardiac dynamics, biomotors, and membrane biophysics. All these researches will have close ties with strong field laser. In the following we briefly describe complex system researches in three universities for comparison: School University of Pennsylvania Tokyo University Purdue University Research Topics About ten PI spanning physics, chemistry and material sciences, with excellent researches in softmatter and materials. A couple of the researchers are world renown, with publications on high impact journals. About nine PI in the field. More emphasis on fundamental nonequilibrium statistical physics and nonlinear dynamics. Some members have had very profound publications in foundations of statistical physics. Total publications are in the same level with ours. Have about nine PI, only some of them are active. Average research performance. Comparison with NCU Many collaborations with other departments and universities, forming jointed experimental/theoretical groups. Both funding and human resources are better than ours. Have much more good Ph.D. students and postdocs than our group. Have about the same levels of human and funding resource with our group, however with better Ph.D. students. We will build upon current researches in NCU, enhance collaboration between research groups, and pool resources and expertise. It is likely that we will be able to become leading complex systems and plasma science research center in Asia. Under this project, the combination of 100 TW laser, advance experiments, theory and computational physics and mathematics could create novel topics and applications. Besides main project office, there are four subprojects, including Strong field laser plasma physics & applications, Frontier complex systems experiment, Theoretical research in nonlinear complex systems, and Pulse light source applications on materials control and diagnosis. Main direction focuses on the international competitiveness of the 100TW laser systems and its technical advancement, together with downstream applications in material and biological systems, with strong theoretical support. These frontier researches will explore new scientific territories and technologies, bringing breakthroughs and a new paradigm to science. (7) Current Status of Cooperation or Integration with Research Centers in the Same Field from Other Universities or Countries and Benefits after Integration This project will extend the applications of 100 TW system. Besides recruiting new faculties, we already have joint research projects with Yang-Ming U., Chao-Tung U., NSYSU., U. of Singapore, and Academic Sinica on biomedical, microscopy, devices, photon-electrical spectroscopy, laser thin film sputtering applications. More research possibilities are 4 Light/Particle Sources Fields 100 TW Laser Condensed Matter Laser sputtering technique for ultrahigh-quality thin film 100 TW Laser Astrophysics High energy relativistic plasma jets 100 TW Laser Plasma Plasma nonlinear optics Femtosecond Pulse Laser Energy Technology Study and control of new organic solar cell materials Femtosecond Pulse Laser Biotechnology Light dynamics therapy and imaging. Membrane, vesicle, ion channel and Ultrafast Pulse Hard X ray Life Sciences X ray Holography Condensed Matter Ultrafast Pulse Soft X Ray THz Pulse Laser High Energy Proton Beam High Energy Proton Beam Resolve dynamics of DNA, RNA, protein and polymers Femtosecond time scale defect dynamics in ion implanting of silicon substrate Relevant Institutions Physics, Material Science & Industry Astronomy and Space Science Physics & Space Science Physics, Chemistry & Material Science Biomedicine & Teaching Hospital Life Science and Biochemistry Physics, Material Science & Industry Chemical Dynamics Electron excitation analysis in photon emission AMO & Chemistry Condensed Matter Probe material structure Plasma Probe high density plasma Astrophysics Simulation high energy Coulomb explosion Subjects cell manipulation High Energy Proton Beam Medicine Proton beam therapy Pulse Neutron Beam Condensed Matter Time resolve study of magnetic material Positron Beam High Energy Physics Create electron-positron plasma Physics, Chemistry & Material Science Physics & Space Science Astronomy Biomedicine & Teaching Hospital Physics, Material Science & Industry Physics (8) Plans for Integrating Resources from Research Centers to achieve the Aim for the Top University The project will combine expertise from Physics, Biophysics, Optics and Photonics, Chemistry, Life Sciences, Chemical Engineering and Material Engineering, Material Sciences, Energy, and Biomedicine in the university. All kinds of ultrafast light and particle sources and life sciences/soft matters core facility equipments will support advance researches in whole campus. 5 II. Project Content (1) Main Project (Project Investigator: CHEN, Pei-Long) The executive committee under the main project consists of the Chairman of Physics Department and three sub-project leaders for the long-term development, planning and supervising various projects. The main project will promote inter-sub-project collaborations, sharing resources, conduct administrative work such as purchasing, hiring, organizing workshops & meetings both locally and internationally. This project emphases the integration of various expertise in different groups for leading-edge research, for example the project of using femto-second laser to activate living cells/vesicles integrate inter-disciplinary strengths from 5 different groups. (2) Component 1: Strong Field Laser Plasma Physics & Applications (Project Investigator: WANG, Jyh-Pyng) In the last 4 years, we constructed a high-quality, multi-beam 100TW laser system to make high energy, high flux, ultra-fast photon and particle sources available in university-level laboratory, and also developed downstream applications. The first item is high-quality electron accelerator and X-ray lasers. Currently there are 1GeV level laser-plasma electron accelerators available internationally. However electron flux and beam stability are not good enough for practical use. We have developed unique plasma waveguide technique. If we can master the optical control of electron injection, its combination with the waveguide technique will yield stable high flux, high energy electron beams. With such beams, we can further develop ion channel free electron laser to achieve 10 keV X rays and also reverse Compton scattering technique to obtain photons between 10 keV X rays and 2 MeV gamma rays. These wavelength-tunable light beams can excite nuclear energy levels, a valuable new tool for studying nuclear physics. High quality electron accelerator can also be used to generate large quantity of positrons. If these positrons can be trapped with electrons inside a Paul Trap, we can study the electron-positron plasmas which will be a significant breakthrough in astrophysics. In 32.8 nm band, the X ray laser we developed based on plasma waveguide has very high brightness, 400 billion times that of synchrotron radiation. This can be used on ultra-fast X ray flash photograph, coherent scattering, holography, as well as X ray nonlinear optics. Besides X ray intensity, beam quality and stability are also the key elements in application. Thus development in these aspects is also our top priority. Besides X ray lasers, high harmonic generations are also important X ray source. Using our advantage in double frequency-triple light sources, we may be able to achieve multi-period quasi phase matching, extending high harmonics to 2.5-4 nm bands. On the other hand, interaction between laser and solid film is also an important emerging field. High power laser can push out electrons in solid thin film, creating a strong Coulomb accelerating electrical fields and accelerating protons. High energy protons are important particles for clinical radiation therapy. How to obtain 200 MeV protons from 100 TW to 1 PW laser is a very important research topic. Although we do not have PW lasers, as long as we can understand the mechanism of proton acceleration, through international collaborations using national-lab-class facility, we can still try to demonstrate such experiments. Because solids have much higher electron density than gas, if we can control electron density and energy distribution, the electrons can be used to generate positrons and reverse Compton scattering. High power laser can control dynamics of plasmas, which can also affect laser propagation, creating infrared, THz light, and X 6 rays. The key is to control this feedback loop. Intense electromagnetic field will also produce nonlinear plasma dynamics due to relativistic effects, leading to double refraction and polarization. This is also a new topic, which will help the study of black holes, neutron stars and pulars. (3) Component 2: Frontier Complex Systems Experiment (Project Investigator: LIN, I) Compared to the large scale strong field laser plasma facility, this subproject mainly composes smaller scale advance complex system experiments. Based on excellent infrastructures and researches supported by the funding of previous phase, there will be experiments on strongly coupled dusty plasma liquids, complex and bio-fluids, neural networks and heart dynamics, biomembrane, cell molecular motor and advance nano-bio imaging. Researches come from Physics, Biophysics, Life Science, and Chemical & Material Engineering in NCU. All the problems in the subproject have very close connections in both fundamental theoretical principle and experiment. They are studying nonlinear spatial structures and dynamics of different complex systems. For example in strongly coupled dusty plasma, microscale suspended charge particles organized into liquid state through mutual interaction. By direct observation of individual motions, we can understand dynamics and structure of liquid from micromotions. Under strong interaction and random thermal motion, cold liquids exhibit local order and multiple length scale and dynamics. This dynamics is very similar to the synchroized and non-synchronized firing in neuron network and heart system. Bio- and lipid membranes are also strongly coupled cold liquid systems, with unique ion channels. From the view points of complex fluids, dusty plasma liquids, granular flows, or bioflows such as bacteria colony all share common multiple spatial and temporal mode excitation and energy transfer. Biofluids also have unique self excitations. All experiments in the subproject share many experiment methodology and equipments. This includes the digital imaging and analysis for large spatial and temporal dynamical ranges, and local position controls with lasers. Biological sample preparation and measurement will also be done in the core facilities setup during the previous phase. Excitation and probe of neuron and heart system also utilize strong, short pulse lasers developed in subproject 1. (4) Component 3: Theoretical Research in Nonlinear Complex Systems (Project Investigator: LAI, Pik-Yin) The subproject combines theorists from physics, mathematics, biophysics, system biology and bioinformatics, complex systems, and brain research center. The focus will be on fundamental theory, mathematical tools, computer simulations, and theoretical models, spanning wide spectrum of topics such as biophysics, soft matters, nonlinear physics, dynamical systems, plasma theory and simulations. Simulations are common in these problems, mostly using large scale computations to study strongly coupled and nonlinear systems. Specific questions using multi-CPU parallel computations include strong field plasma, coupled nonlinear dynamics, complex network dynamics and function detection, multiple cell systems, cell evolution, complex fluid, and bioflows. With the support of Center of Mathematics and Theoretical Physics, cross-discipline collaboration will also be greatly enhanced. 7 (5) Component 4: Pulse Light Source Applications on Materials Control and Diagnosis (Project Investigator: CHEN, Szu-Yuan) The subproject is to use the THz, infrared, visible light, UV, soft and hard X ray, and gamma ray pulse source generated from high power infrared pulse laser system (including 10 TW laser in Academic Sinica and 100 TW laser in NCU) and corresponding laser plasma systems to development new techniques of novel materials. These materials will have great application potentials in optics, energy, medicine, and electronics. These light sources can probe the mechanisms of material growth, properties, and applications. Laser plasmas are very efficient in board-band light wavelength transformation. It can be used to produce full bandwidth pulse light sources, providing an effect tools for probing of material static properties, as well as dynamics. Because the high intensity of light pulse, it can also be used to control growth morphology. Lights have been used extensively in past decades as material probing tools. However there are relative few studies using lights for controlling purposes. We will use pulse lights in different wave lengths to create a new material growth platform. We will try to control various material processing stages, such as target sputtering, plasma or molecule flight, substrate surface diffusion, substrate preprocessing and sample light post processing. Light can also be used to study and control solar cell, solar hydration device, organic and semiconductor light-emitting device, quantum computing device, ultrafast magnetic device, free radical removing drugs or devices, antibiotics, protein structure analysis, nuclear quantum optics and nonlinear optics. III. Overall and Annual Objectives (1) Overall Objectives This project is to perform advance research through resource and expertise from different laboratories. Previous phase focused on infrastructure. This phase will be mostly on human resources and equipments. We expect to publish 50 papers in high impact journals such as PRL and PNAS. The goals are shown in Fig. 1. (2) Annual Objectives Detail research progress plan is listed in Fig. 2. IV. Response and Improvements to Initial Review Opinions Initial review opinion: The thrust area has proposed a very well defined plan to use its 100TW Laser-Plasma facility. The only question is how do they plan to integrate this research into the education process? Also, it would be worthy to have a website to inform the public of their achievements – maybe there already is a website, but if so, it is not mentioned in the proposal. 8 Response: We are very thankful to the positive review comments. We will increase our education and outreach programs of 100 TW laser experiments. Some of the more basic experimental techniques will be integrated into various physics courses, nurturing interests and ability on advance optics. It will also serve the purpose of preparing new generation of students on strong field laser research. The outreach programs will conclude public lectures and demonstrations for general public. The web links for our projects and groups are also added in the web pages of physics department http://www.phy.ncu.edu.tw/en/index.php 9 Fig 1. Project Goals Fig 2. Detail research progress plan (next two pages) 10 2012 2011 Build high contrast pre-optical parametric amplifer to a contrast of 1010 to solve the problem of pre-ionization in solid target Simulation study of multiple layer solid thin film target for the increase of proton energy and flux Increase efficient of plasma lens to increase laser contrast. Expecting an increase of 100-1000 fold in laser contrast Develop X ray holography with 100 nm resolution. Study of plasma waveguide with H, He or N, to avoid the problem of waveguide destroyed by excessive electrons Overcome the problem of nonlinear evolution of high energy laser pulse in plasma waveguide, for stable and high flux electrons. Problem of coupling between laser pulse and plasma waveguide for waveguide efficiency Time resolved photo-electron spectroscopy to study magnet femtosecond reversal mechanism THz light probing of melanin thin film for the mechanism of voltage switching Laser pulse control of growth of diamond thin film 2013 Develop positron trap technique Develop X ray holography with 20 nm resolution Free electron laser using micro proton channel to achieve keV X ray. Super narrow laser pulse laser deposition to grow carbon nanoparticle Reverse Compton scattering to obtain tunable gamma rays. Develop X ray fluorescent spectroscopy. Real time observation of microstructure of carbon thin film with femtosecond X ray Multiple femtosecond pulse to resovle mechanism of light sensitive die molecules for solar cell application Infrared spectrum control heating to control crystal growth 11 Laser deposition of high quality melanin thin film Infrared induced crystallization of protein and other biomolecules. Purify carbon isotope with laser to enhance decoherent time of nitrogen defect Use AC Paul trap to trap electrons and positrons for the creation of electron-positron plasma Use the X ray to resolve surface light chemistry and shock wave With plasma nonlinear phase modulation to create high energy infrared pulse, with which to produce high harmonics to ionize and control molecular vibration. Accelerate electrons in waveguide Laser induced microarray to control ion implant distribution and nitrogen defect in diamond. Coulomb explosion and plasma wave propagation of high density plasma study with X ray or proton beam Develop two-photon autocorrelation devices to measure pulse length of X ray Try to achieve Xe26+ X ray laser in wavguide Resolve secondary structure with UV pulse, for the ability to control these structures 2015 Produce 200Mev proton beam with PW facility under international collaboration Using electron beam to create positron by colliding on metal target Study how to produce large quantities of electrons from thin film target. Use relativistic laser Doppler effect to shift laser pulse to X ray wavelength Super narrow laser pulse laser deposition to achieve 100 femtosecond magnetic reversal 2014 Hard X ray ultrashort pulse for single molecule image, with application on non-crystal protein Pulse laser deposition of TiO2 thin film with combination of melanin thin film for height efficiency solar cell Study nuclear induced transparency, nuclear Raman effects and two-photon nuclear excitation 2011 2012 In vitro live heart cell and whole heart dynamical experiments. Heart muscle cell exicitation nonlinear dynamics theory In vitro whole heart VT and VF induction and dynamics observations Effect of temperature and stimuli on the variation of heart beat Coupled nonlinear excitable and oscillatory system and biological time sequence analysis Construct multi-electrode electro-physiology measurement system. Using electrode array to study in vitro neuron dynamics. Calcium fluorenscent measure of large scale neuron firing Computer control of specific neurons and gilia cells. Study synapse plasticity and role of gilia cell in neuron netowork. Control interaction with magnets between granular particles Construct interaction-tunable airbed granular experimental system Design controllable external stimuli to study mechanism of short term memory Dusty plasma supercool and glass state study Microscopic waveform study of nonlinear dusty plasma wave Dusty plasma supercool state and critical slowing down. Long chain liquid dynamics Create chiral granular particle. Study supercool and glass states under external driving Parallel computing of particle motions, matching particle properties with experimental ones. Setup large scale particle simulation system, including hardware setup and software development. Simulation of large scale parallel computation of strong field plasma physics, calculating how to generate large quantities of electrons from thin film target. Setup particle and bacteria behavior experiments in temperature and concentration gradients Setup single biomolecule and molecular motor lab. 2014 2013 Measure of particle dynamics in temperature and concentration gradients Bacteria flagella motor high resolution fluorescent and rotating measurement Setup super high resolution fluorescent system. Study dynamics of rotor and stator in bacteria flagella motor 12 2015 Using nonlinear time sequence analysis to study precursor of VT and VF, with possible clinical application. Design flexible neuron network and synapse connectivity to study mechanism of learning Microscopic study of turbulence Study turbulence Dynamics of live long chain under shear Simulation composite particles such as long chains Compute electron-proton double layers and study how to increase proton energy and flux Measure of cell dynamics in temperature and concentration gradients Flagella motor ion flux measurement and rotating behavior Website Link for the Full Version of the Aim for Top University Project Proposal and Related Attachments http://pine.cc.ncu.edu.tw/~ncutop/index.php?lang=2 Step 1:Login. 1 Step 2:Login with user account:ncu7020 Password:ncu57025 Step 3:Select “Achievements & Future Plans” 3 2 Step 4:Select 「The Aim for Top University Project Proposal」 13 4 Step 5:Browse for the attachments of the project proposal of each key field. 5 14