DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY David A. Taylor, Chairperson PHAR: PHARMACOLOGY 7601. Medical Pharmacology for Health Sciences I (3) Lectures only. P: Bachelor’s or master’s degree in science or health profession; or consent of chair. Survey of pharmacodynamics, pharmacokinetics, adverse effects, and pharmacotherapeutic principles of drugs affecting autonomic, cardiovascular, respiratory, renal, and central nervous systems. 7602. Medical Pharmacology for Health Sciences II (3) Lectures only. P: Bachelor’s or master’s degree in science or health profession; or consent of chair. Survey of pharmacodynamics, pharmacokinetics, adverse effects, and pharmacotherapeutic principles of anesthetic, antimicrobial, antineoplastic, endocrine, and other therapeutic agents. Includes toxicology and treatment of poisonings. 7603. Pharmacology for Health Sciences (4) Lectures. P: Bachelor’s or master’s degree in science or health professions or consent of chair: Survey of pharmacodynamics, pharmacokinetics and adverse effects of drugs in various categories including: autonomic, cardiovascular, respiratory, renal, anesthetic, CNS, chemotherapy, endocrine, toxicology. 7604. Pharmacology for Health-Related Sciences (5) Lectures, small group conferences. P: Bachelor’s or master’s degree in science or health professions or consent of chair: Survey of pharmacodynamics, pharmacokinetics and clinical aspects of drugs in various categories including: autonomic, cardiovascular, respiratory, renal, anesthetic, CNS, chemotherapy, endocrine, toxicology. 6605. 7605 Seminar* (1) Formerly PHAR 6605 May be repeated. P: Consent of chair. Formal presentation and exchange of research ideas by faculty, distinguished guest speakers, and students. Scientific journal articles will also be periodically critiqued. 6609. 7609 Introduction to Pharmacology* (3) Formerly PHAR 6609 P: Previous admission to graduate program in biomedical sciences in School of Medicine and concurrent registration in graduate biochemistry and physiology; or consent of chair. History and scope of pharmacology; pharmacokinetics including the quantitative principles of uptake, distribution, biotransformation and elimination of drugs; and pharmacodynamics including dose and time-response relationships, pharmacokinetics, and factors modifying cellular mechanisms of drug actions. 6610. 7610 Basic Mechanisms of Drug Action* (3) Formerly PHAR 6610 P: BIOC 7300 PHAR 7609; BIOL 5800 or equivalent; PHLY 7702; or equivalent; or consent of chair. Fundamental mechanisms by which drugs affect physiology and biochemistry of living systems at macromolecular, cellular, organ, systemic, and multisystemic levels. 7614. Research Procedures I (2) P: Consent of chair; admission to graduate program in the Department of Pharmacology and Toxicology. Scheduled, fixed time assignment of new graduate students to the research laboratories of various department faculty members. Introduces new students to research programs of each department faculty member, prepares them for selection of an appropriate dissertation advisor and also develops and assesses basic research skills. 6615. 7615 Research Procedures*II (2) Formerly PHAR 6615 May be repeated. P: PHAR 7614; Admission to the graduate program in the Department of Pharmacology and Toxicology or consent of chair. Assigned to faculty preceptors. May precede beginning of thesis research. May be repeated. P: Consent of chair. Design of experimental protocol and collaboration in some aspect of preceptor’s program. Graduate students conduct directed research in the laboratory of faculty members assigned for direction of preliminary studies for dissertation research. 6640. 7640 Pharmacology of the Central Nervous System (3) Formerly PHAR 6640 P: BIOC 7300; BIOL 5800; PHLY 7702; or consent of chair. Basic neuropharmacological principles. Theories dealing with mechanisms of action of CNS drugs. Causes and treatment of major psychiatric and neurological disorders and basis of drug abuse taught through directed literature readings and class presentations and discussions. 6660. 7660 Cardiovascular Pharmacology (3) Formerly PHAR 6660 P: Admission to the graduate program in any of the basic science departments or consent of chair. The course enables students to understand the pathophysiology and pharmacotherapeutics of cardiovascular diseases through directed literature readings, class presentations and discussions. 7665. Pedagogy in Pharmacology (2) P: Successful completion of doctoral candidacy exam in Dept. of Pharmacology; consent of chair. Instruction, mentoring, and supervision in teaching of topics in pharmacology to health science, doctoral, and/or medical students. 6670. 7670 Research Techniques (3) Formerly PHAR 6670 P: PHAR 6609 or equivalent; or consent of course director. Advanced lab techniques in biomedical research. Molecular cloning, protein methods, equilibrium binding analysis, enzyme assays, microscopy, isolated tissue preparations, anesthesia, stereotaxic surgery, and behavioral paradigms. Each lab preceded by lecture covering relevant material. 7680. Toxicology (3) P: PHLY 6700; BIOL 5800 or equivalent; consent of chair. Principles of toxicology and the mechanisms that underlie toxic effects from the subcellular to the organism level will be discovered. In addition, patterns of toxicity of specific chemicals will be discussed, as well as how those results can be employed in risk assessment. 7777. Practical Problems in Biometry (3) P: College algebra; consent of chair or course director. Provides working knowledge of experimental design, analysis of variance, and other techniques. 8601. Medical Pharmacology I* (5) Lectures, small-group conferences, and computer-assisted labs. P: BIOC 7300; PHLY 7702; consent of chair. Survey of pharmacodynamics, pharmacokinetics, adverse effects, and pharmacotherapeutic principles of drugs affecting autonomic, cardiovascular, respiratory, renal, and central nervous systems. 8602. Medical Pharmacology II (5) Lectures, small-group conferences, and clinical practicum. P: BIOC 7300; PHLY 7702; consent of chair. Survey of pharmacodynamics, pharmacokinetics, adverse effects, and pharmacotherapeutic principles of anesthetic, antimicrobial, antineoplastic, endocrine, and other therapeutic agents. Includes toxicology and treatment of poisonings. 9000. Dissertation (3-12) May be repeated. May count maximum of 18 s.h. 9001. Dissertation: Summer Research (1) May be repeated. No credit may count toward degree. Students conducting dissertation research may only register for this course during the summer. PHAR Banked Courses 6650. Advanced Topics in Pharmacology (2) 6655. Pharmacological Regulation and Identification of Receptors (3)