Supplementary Table 1: Cell populations used in metastasis assays.
Metastatic propensity to bone and lung for all in vivo selected and single cellderived populations used in the study.
Cell Line
Lung
Metastatic
Activity
Bone
Metastatic
Activity
Parental
1833
1834
3475
3481
2293
2295
4142
4173
4175
4180
SCP 2
SCP 3
SCP 6
SCP 21
SCP 25
SCP 26
SCP 28
SCP 32
SCP 43
SCP 46
-/+
-/+
+
++
++
+
+
+++
+++
+++
+++
-/+
+
-/+
+
+
+
-/+
+
+++
+
+
+
+
+
+
+
+
+
+++
+
-/+
++
+++
+
+
+++
Supplementary Table 2: Class comparison between parental MDA-MB-231
and LM2 cell lines selected to be highly metastatic to lung. Shown are 95
unique genes from 113 Affymetrix probe sets. Yellow marks 61 overexpressed
probe sets and blue marks 52 underexpressed probe sets after a three-fold filter
was applied.
Probe set
200665_s_at
203029_s_at
203030_s_at
207442_at
206172_at
Fold
Change
407.01
147.27
97.07
58.71
48.52
206785_s_at
202310_s_at
211534_x_at
33.05
20.03
15.67
221261_x_at
202947_s_at
204475_at
217388_s_at
205767_at
201645_at
204698_at
205623_at
212091_s_at
213711_at
210663_s_at
14.65
13.50
13.35
12.82
8.99
7.43
6.77
6.75
6.35
6.34
6.29
204748_at
201720_s_at
203571_s_at
6.23
5.83
5.74
204205_at
205463_s_at
213194_at
5.29
5.02
4.86
212190_at
220217_x_at
221009_s_at
4.63
4.56
4.56
201564_s_at
216268_s_at
201417_at
220922_s_at
4.55
4.47
4.45
4.40
Gene Title
secreted protein, acidic, cysteine-rich (osteonectin)
protein tyrosine phosphatase, receptor type, N polypeptide 2
protein tyrosine phosphatase, receptor type, N polypeptide 2
colony stimulating factor 3 (granulocyte)
interleukin 13 receptor, alpha 2
killer cell lectin-like receptor subfamily C, member 1 /// killer
cell lectin-like receptor subfamily C, member 2
collagen, type I, alpha 1
protein tyrosine phosphatase, receptor type, N polypeptide 2
melanoma antigen, family D, 4 /// melanoma antigen, family D,
4
glycophorin C (Gerbich blood group)
matrix metalloproteinase 1 (interstitial collagenase)
kynureninase (L-kynurenine hydrolase)
Epiregulin
tenascin C (hexabrachion)
Interferon stimulated gene 20kDa
Aldehyde dehydrogenase 3 family, memberA1
collagen, type VI, alpha 1
keratin, hair, basic, 1
kynureninase (L-kynurenine hydrolase)
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H
synthase and cyclooxygenase)
Lysosomal-associated multispanning membrane protein-5
chromosome 10 open reading frame 116, adipose specific 2
apolipoprotein B mRNA editing enzyme, catalytic polypeptidelike 3G
platelet-derived growth factor alpha polypeptide
roundabout, axon guidance receptor, homolog 1 (Drosophila)
serine (or cysteine) proteinase inhibitor, clade E (nexin,
plasminogen activator inhibitor type 1), member 2
SPANX family, member C
angiopoietin-like 4
fascin homolog 1, actin-bundling protein (Strongylocentrotus
purpuratus)
jagged 1 (Alagille syndrome)
SRY (sex determining region Y)-box 4
SPANX family, member B1 /// SPANX family, member C
Gene
Symbol
SPARC
PTPRN2
PTPRN2
CSF3
IL13RA2
KLRC1 ///
KLRC2
COL1A1
PTPRN2
MAGED4
GYPC
MMP1
KYNU
EREG
TNC
ISG20
ALDH3A1
COL6A1
KRTHB1
KYNU
PTGS2
LAPTM5
C10ORF116
APOBEC3G
PDGFA
ROBO1
SERPINE2
SPANXC
ANGPTL4
FSCN1
JAG1
SOX4
SPANXB1
201288_at
213428_s_at
220921_at
33304_at
205174_s_at
4.26
4.24
4.21
4.16
4.01
210933_s_at
3.99
204470_at
3.89
201069_at
205399_at
201061_s_at
221902_at
221760_at
219563_at
3.85
3.76
3.71
3.62
3.59
3.57
211368_s_at
209030_s_at
202728_s_at
204385_at
209505_at
201325_s_at
201721_s_at
3.54
3.42
3.41
3.24
3.24
3.21
3.21
206097_at
201324_at
203417_at
3.17
3.15
3.12
208937_s_at
219911_s_at
222182_s_at
222103_at
203585_at
221911_at
216488_s_at
205017_s_at
210046_s_at
213075_at
3.10
3.10
3.07
3.07
3.06
3.02
0.33
0.33
0.33
0.33
202149_at
0.32
202610_s_at
0.32
210340_s_at
0.32
221011_s_at
219959_at
213537_at
0.32
0.31
0.31
Rho GDP dissociation inhibitor (GDI) beta
collagen, type VI, alpha 1
SPANX family, member B1
Interferon stimulated gene 20kDa
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
fascin homolog 1, actin-bundling protein (Strongylocentrotus
purpuratus)
chemokine (C-X-C motif) ligand 1 (melanoma growth
stimulating activity, alpha)
matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase,
72kDa type IV collagenase)
doublecortin and CaM kinase-like 1
Stomatin
G protein-coupled receptor 153
mannosidase, alpha, class 1A, member 1
chromosome 14 open reading frame 139
caspase 1, apoptosis-related cysteine protease (interleukin 1,
beta, convertase)
immunoglobulin superfamily, member 4
latent transforming growth factor beta binding protein 1
kynureninase (L-kynurenine hydrolase)
nuclear receptor subfamily 2, group F, member 1
epithelial membrane protein 1
Lysosomal-associated multispanning membrane protein-5
solute carrier family 22 (organic cation transporter), member 1like antisense
epithelial membrane protein 1
microfibrillar-associated protein 2
inhibitor of DNA binding 1, dominant negative helix-loop-helix
protein
solute carrier organic anion transporter family, member 4A1
CCR4-NOT transcription complex, subunit 2
Activating transcription factor 1
zinc finger protein 185 (LIM domain)
hypothetical protein LOC221810
ATPase, Class VI, type 11A
muscleblind-like 2 (Drosophila)
isocitrate dehydrogenase 2 (NADP+), mitochondrial
olfactomedin-like 2A
neural precursor cell expressed, developmentally downregulated 9
cofactor required for Sp1 transcriptional activation, subunit 2,
150kDa
colony stimulating factor 2 receptor, alpha, low-affinity
(granulocyte-macrophage)
likely ortholog of mouse limb-bud and heart gene /// likely
ortholog of mouse limb-bud and heart gene
molybdenum cofactor sulfurase
major histocompatibility complex, class II, DP alpha 1
/// SPANXC
ARHGDIB
COL6A1
SPANXB1
ISG20
QPCT
FSCN1
CXCL1
MMP2
DCAMKL1
STOM
GPR153
MAN1A1
C14orf139
CASP1
IGSF4
LTBP1
KYNU
NR2F1
EMP1
LAPTM5
SLC22A1LS
EMP1
MFAP2
ID1
SLCO4A1
CNOT2
ATF1
ZNF185
LOC221810
ATP11A
MBNL2
IDH2
OLFML2A
NEDD9
CRSP2
CSF2RA
LBH
MOCOS
HLA-DPA1
202237_at
206473_at
201428_at
201843_s_at
202017_at
202688_at
205018_s_at
203387_s_at
212372_at
205805_s_at
216060_s_at
203974_at
204149_s_at
210136_at
214040_s_at
213067_at
207379_at
201137_s_at
208306_x_at
215193_x_at
202986_at
206814_at
204070_at
202238_s_at
201842_s_at
0.30
0.30
0.30
0.30
0.30
0.30
0.29
0.29
0.28
0.27
0.27
0.26
0.25
0.25
0.24
0.24
0.24
0.23
0.23
0.23
0.23
0.22
0.21
0.21
0.21
207620_s_at
211990_at
202350_s_at
0.18
0.18
0.17
211907_s_at
207214_at
211839_s_at
208209_s_at
202145_at
211991_s_at
204238_s_at
209394_at
208161_s_at
209201_x_at
210140_at
212942_s_at
217028_at
214827_at
0.16
0.16
0.16
0.16
0.14
0.13
0.12
0.10
0.09
0.08
0.07
0.07
0.06
0.04
nicotinamide N-methyltransferase
membrane-bound transcription factor protease, site 2
claudin 4
EGF-containing fibulin-like extracellular matrix protein 1
epoxide hydrolase 1, microsomal (xenobiotic)
tumor necrosis factor (ligand) superfamily, member 10
muscleblind-like 2 (Drosophila)
TBC1 domain family, member 4
myosin, heavy polypeptide 10, non-muscle
receptor tyrosine kinase-like orphan receptor 1
dishevelled associated activator of morphogenesis 1
haloacid dehalogenase-like hydrolase domain containing 1A
glutathione S-transferase M4
LOC388483
gelsolin (amyloidosis, Finnish type)
myosin, heavy polypeptide 10, non-muscle
EGF-like repeats and discoidin I-like domains 3
major histocompatibility complex, class II, DP beta 1
major histocompatibility complex, class II, DR beta 3
major histocompatibility complex, class II, DR beta 3
aryl-hydrocarbon receptor nuclear translocator 2
nerve growth factor, beta polypeptide
retinoic acid receptor responder (tazarotene induced) 3
nicotinamide N-methyltransferase
EGF-containing fibulin-like extracellular matrix protein 1
calcium/calmodulin-dependent serine protein kinase (MAGUK
family)
Major histocompatibility complex, class II, DP alpha 1
matrilin 2
par-6 partitioning defective 6 homolog beta (C. elegans) /// par6 partitioning defective 6 homolog beta (C. elegans)
serine protease inhibitor, Kazal type 4
colony stimulating factor 1 (macrophage)
complement component 4 binding protein, beta
lymphocyte antigen 6 complex, locus E
major histocompatibility complex, class II, DP alpha 1
chromosome 6 open reading frame 108
acetylserotonin O-methyltransferase-like
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chemokine (C-X-C motif) receptor 4
cystatin F (leukocystatin)
KIAA1199
chemokine (C-X-C motif) receptor 4
par-6 partitioning defective 6 homolog beta (C. elegans)
NNMT
MBTPS2
CLDN4
EFEMP1
EPHX1
TNFSF10
MBNL2
TBC1D4
MYH10
ROR1
DAAM1
HDHD1A
GSTM4
--GSN
MYH10
EDIL3
HLA-DPB1
HLA-DRB3
HLA-DRB3
ARNT2
NGFB
RARRES3
NNMT
EFEMP1
CASK
--MATN2
PARD6B
SPINK4
CSF1
C4BPB
LY6E
HLA-DPA1
C6orf108
ASMTL
ABCC3
CXCR4
CST7
KIAA1199
CXCR4
PARD6B
Supplementary Table 3: Overlapping genes between lung and bone
metastasis signatures. The 113 probe sets (95 unique genes) from
Supplementary Table 2 were overlapped with the 127 probe sets (102 unique
genes) previously identified as the gene-expression signature of MDA-MB-231
cell populations that are highly metastatic to bone. Shown are 9 intersecting
genes (11 probe sets) and whether each is up-regulated or down-regulated in
either the bone metastasis signature or the lung metastasis signature.
Probe set
Description
Gene symbol
Bone
Lung
201417_at
SRY (sex determining region Y)-box 4
SOX4
down
up
203571_s_at
adipose specific 2
C10orf116
down
up
208161_s_at
ATP-binding cassette, sub-family C (CFTR/MRP), 3
ABCC3
down
down
211991_s_at
major histocompatibility complex, class II, DP alpha 1
HLA-DPA1
down
down
219563_at
chromosome 14 open reading frame 139
C14orf139
up
up
204475_at
matrix metalloproteinase 1 (interstitial collagenase)
MMP1
up
up
209201_x_at
CXCR4
up
down
SPANXA1
up
up
220922_s_at
Chemokine (C-X-C motif) receptor 4
sperm protein associated with the nucleus, X
chromosome, family member A1
sperm protein associated with the nucleus, X
chromosome, family member A1
SPANXA1
up
up
215193_x_at
major histocompatibility complex, class II, DR beta 1
HLA-DRB1
down
down
201137_s_at
major histocompatibility complex, class II, DP beta 1
HLA-DPB1
down
down
220921_at
Supplementary Table 4: Lung metastasis candidate genes. Shown are 54
unique genes from 65 Affymetrix probe sets representing genes associated with
lung metastagenicity and virulence. Overexpressed fold change (yellow) and
underexpressed fold change (blue) from comparing parental MDA-MB-231 and
the LM2 cell lines are indicated.
Probe set
200665_s_at
212667_at
206172_at
Fold
Change
Gene Title
Gene
Symbol
secreted protein, acidic, cysteine-rich (osteonectin)
interleukin 13 receptor, alpha 2
killer cell lectin-like receptor subfamily C, member 1 /// killer cell
lectin-like receptor subfamily C, member 2
matrix metalloproteinase 1 (interstitial collagenase)
SPARC
IL13RA2
KLRC1 ///
KLRC2
MMP1
kynureninase (L-kynurenine hydrolase)
Epiregulin
tenascin C (hexabrachion)
interferon stimulated gene 20kDa
aldehyde dehydrogenase 3 family, memberA1
keratin, hair, basic, 1
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H
synthase and cyclooxygenase)
KYNU
EREG
TNC
ISG20
ALDH3A1
KRTHB1
LAPTM5
C10orf116
ROBO1
SPANXC
ANGPTL4
4.55
Lysosomal-associated multispanning membrane protein-5
chromosome 10 open reading frame 116, adipose specific 2
roundabout, axon guidance receptor, homolog 1 (Drosophila)
SPANX family, member C
angiopoietin-like 4
fascin homolog 1, actin-bundling protein (Strongylocentrotus
purpuratus)
4.45
SRY (sex determining region Y)-box 4
4.40
4.24
SPANX family, member B1 /// SPANX family, member C
collagen, type VI, alpha 1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating
activity, alpha)
matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase,
72kDa type IV collagenase)
Stomatin
G protein-coupled receptor 153
mannosidase, alpha, class 1A, member 1
chromosome 14 open reading frame 139
caspase 1, apoptosis-related cysteine protease (interleukin 1,
beta, convertase)
immunoglobulin superfamily, member 4
SOX4
SPANXB1
/// SPANXC
COL6A1
407.01
48.52
206785_s_at
204475_at
217388_s_at
210663_s_at
205767_at
201645_at
204698_at
205623_at
213711_at
33.05
13.35
204748_at
201720_s_at
201721_s_at
203571_s_at
213194_at
220217_x_at
221009_s_at
201564_s_at
210933_s_at
201417_at
201416_at
220922_s_at
220921_at
213428_s_at
6.23
204470_at
3.89
201069_at
201061_s_at
221902_at
221760_at
219563_at
3.85
3.71
3.62
3.59
3.57
211368_s_at
209030_s_at
3.54
3.42
12.82
8.99
7.43
6.77
6.75
6.34
5.83
5.74
4.86
4.56
4.56
PTGS2
FSCN1
CXCL1
MMP2
STOM
GPR153
MAN1A1
C14orf139
CASP1
IGSF4
202728_s_at
209505_at
201325_s_at
201324_at
3.41
3.24
latent transforming growth factor beta binding protein 1
nuclear receptor subfamily 2, group F, member 1
LTBP1
NR2F1
3.21
EMP1
208937_s_at
222182_s_at
203868_s_at
213075_at
3.10
3.07
2.17
0.33
202149_at
0.32
210340_s_at
219959_at
202017_at
205018_s_at
205017_s_at
210136_at
214040_s_at
213067_at
202986_at
204070_at
201842_s_at
201843_s_at
202350_s_at
202145_at
211991_s_at
213537_at
209394_at
208161_s_at
212942_s_at
217028_at
209201_x_at
214827_at
0.32
0.31
0.30
epithelial membrane protein 1
inhibitor of DNA binding 1, dominant negative helix-loop-helix
protein
CCR4-NOT transcription complex, subunit 2
vascular cell adhesion molecule 1
olfactomedin-like 2A
neural precursor cell expressed, developmentally downregulated 9
colony stimulating factor 2 receptor, alpha, low-affinity
(granulocyte-macrophage)
molybdenum cofactor sulfurase
epoxide hydrolase 1, microsomal (xenobiotic)
0.29
0.25
0.24
0.24
0.23
0.21
muscleblind-like 2 (Drosophila)
LOC388483
gelsolin (amyloidosis, Finnish type)
myosin, heavy polypeptide 10, non-muscle
aryl-hydrocarbon receptor nuclear translocator 2
retinoic acid receptor responder (tazarotene induced) 3
MBNL2
--GSN
MYH10
ARNT2
RARRES3
0.21
0.17
0.14
EGF-containing fibulin-like extracellular matrix protein 1
matrilin 2
lymphocyte antigen 6 complex, locus E
EFEMP1
MATN2
LY6E
0.13
0.10
0.09
0.07
major histocompatibility complex, class II, DP alpha 1
acetylserotonin O-methyltransferase-like
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
KIAA1199
HLA-DPA1
ASMTL
ABCC3
KIAA1199
0.06
0.04
chemokine (C-X-C motif) receptor 4
par-6 partitioning defective 6 homolog beta (C. elegans)
CXCR4
PARD6B
ID1
CNOT2
VCAM1
OLFML2A
NEDD9
CSF2RA
MOCOS
EPHX1
Supplementary Table 5. Expression of Genes in the Lung Metastasis
Signature Correlated to Lung Metastasis-Free Survival in Breast Cancer
Patients. A Cox proportional hazards model was used to relate gene expression
changes of the 54 gene lung metastasis signature to lung metastasis-free
survival in 82 breast cancer patients.
Probe set
204070_at
221009_s_at
203571_s_at
202728_s_at
205017_s_at
201564_s_at
201324_at
210340_s_at
204475_at
212942_s_at
204470_at
204748_at
202986_at
213067_at
213075_at
222182_s_at
206785_s_at
208161_s_at
202145_at
202017_at
209505_at
210663_s_at
210136_at
219959_at
201061_s_at
213428_s_at
219563_at
220217_x_at
213537_at
213711_at
201645_at
201721_s_at
201842_s_at
213194_at
214040_s_at
220921_at
Gene
Symbol
RARRES3
ANGPTL4
C10orf116
LTBP1
MBNL2
FSCN1
EMP1
CSF2RA
MMP1
KIAA1199
CXCL1
PTGS2
ARNT2
MYH10
OLFML2A
CNOT2
KLRC1
ABCC3
LY6E
EPHX1
NR2F1
KYNU
MBP
MOCOS
STOM
COL6A1
C14orf139
SPANXC
HLA-DPA1
KRTHB1
TNC
LAPTM5
EFEMP1
ROBO1
GSN
SPANXB1
Hazard
Ratio
0.434
2.991
0.608
3.364
3.133
1.975
2.997
1.805
1.313
1.617
1.356
1.451
0.746
0.674
0.434
0.365
0.752
0.776
0.704
0.678
0.806
1.235
1.431
1.359
0.613
1.542
0.657
0.773
0.786
1.100
1.195
1.305
0.865
1.216
1.167
0.892
Lower
95%
0.291
1.661
0.467
1.467
1.357
1.280
1.411
1.212
1.064
1.076
1.076
1.030
0.542
0.429
0.165
0.120
0.544
0.574
0.437
0.387
0.579
0.887
0.809
0.830
0.267
0.722
0.319
0.474
0.493
0.899
0.805
0.634
0.570
0.699
0.717
0.612
Upper
95%
0.648
5.388
0.792
7.711
7.231
3.047
6.369
2.687
1.619
2.431
1.708
2.043
1.026
1.060
1.139
1.108
1.040
1.048
1.136
1.186
1.121
1.718
2.532
2.226
1.408
3.293
1.355
1.261
1.253
1.347
1.772
2.687
1.313
2.113
1.901
1.301
p-value
0.00001
0.00005
0.00047
0.00074
0.00169
0.00201
0.00272
0.00283
0.00742
0.02083
0.02191
0.02628
0.06494
0.06899
0.07305
0.07775
0.08261
0.10283
0.13893
0.17169
0.21238
0.21883
0.22674
0.23861
0.24098
0.25386
0.25881
0.28465
0.33430
0.36209
0.37407
0.48354
0.49742
0.49865
0.51734
0.54461
209030_s_at
202350_s_at
208937_s_at
209394_at
221760_at
205767_at
206172_at
211368_s_at
201069_at
203868_s_at
204698_at
205623_at
201416_at
214827_at
217028_at
221902_at
212667_at
202149_at
IGSF4
MATN2
ID1
ASMTL
MAN1A1
EREG
IL13RA2
CASP1
MMP2
VCAM1
ISG20
ALDH3A1
SOX4
PARD6B
CXCR4
GPR153
SPARC
NEDD9
0.755
0.907
1.156
0.816
0.890
1.058
1.061
1.065
1.079
1.065
0.973
0.957
0.941
0.972
0.953
0.964
0.969
1.033
0.300
0.658
0.716
0.400
0.522
0.814
0.691
0.663
0.592
0.576
0.743
0.598
0.462
0.648
0.482
0.524
0.489
0.510
1.899
1.252
1.866
1.667
1.519
1.374
1.629
1.710
1.966
1.969
1.273
1.531
1.913
1.458
1.884
1.773
1.922
2.092
0.54672
0.55728
0.56958
0.58735
0.66920
0.67603
0.78848
0.79193
0.80346
0.83993
0.84223
0.85511
0.86571
0.88897
0.88906
0.90587
0.92818
0.92853
Supplementary Table 6. Lung Metastasis Signature Genes Used to Classify
Primary Breast Cancers Expressing the Lung Metastasis Signature. All
genes from Table 1 are shown.
UG
cluster
Gene
symbol
Hs.118400
Hs.83169
Hs.9613
Hs.74120
FSCN1
MMP1
ANGPTL4
C10orf116
0.00002
Hs.789
CXCL1
0.000355
0.000444
0.000506
0.000627
0.001263
0.004365
0.005179
0.006426
Hs.196384
Hs.185568
Hs.109225
Hs.17466
Hs.368256
Hs.444471
Hs.421986
Hs.77667
PTGS2
KRTHB1
VCAM1
RARRES3
LTBP1
KYNU
CXCR4
LY6E
0.007153
0.010871
Hs.410900
Hs.255149
ID1
MAN1A1
0.032361
0.03713
0.046859
0.053773
0.05492
0.062067
0.071707
0.079271
0.080391
0.096189
0.097858
0.119096
Hs.388589
Hs.115263
Hs.98998
Hs.357901
Hs.157986
Hs.165725
Hs.436200
Hs.153647
Hs.156682
Hs.306692
Hs.105434
Hs.280311
NEDD9
EREG
TNC
SOX4
MOCOS
CNOT2
LAPTM5
MATN2
IGSF4
EMP1
ISG20
MYH10
0.124785
0.213167
Hs.301198
Hs.361748
ROBO1
NR2F1
Description
Fascin homolog 1, actin-bundling protein
(Strongylocentrotus purpuratus)
Matrix metalloproteinase 1 (interstitial collagenase)
Angiopoietin-like 4
Chromosome 10 open reading frame 116
Chemokine (C-X-C motif) ligand 1 (melanoma growth
stimulating activity, alpha)
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H
synthase and cyclooxygenase)
Keratin, hair, basic, 1
Vascular cell adhesion molecule 1
Retinoic acid receptor responder (tazarotene induced) 3
Latent transforming growth factor beta binding protein 1
Kynureninase (L-kynurenine hydrolase)
Chemokine (C-X-C motif) receptor 4
Lymphocyte antigen 6 complex, locus E
Inhibitor of DNA binding 1, dominant negative helix-loophelix protein
Mannosidase, alpha, class 1A, member 1
Neural precursor cell expressed, developmentally downregulated 9
Epiregulin
Tenascin C (hexabrachion)
SRY (sex determining region Y)-box 4
Molybdenum cofactor sulfurase
CCR4-NOT transcription complex, subunit 2
Lysosomal-associated multispanning membrane protein-5
Matrilin 2
Immunoglobulin superfamily, member 4
Epithelial membrane protein 1
Interferon stimulated gene 20kDa
Myosin, heavy polypeptide 10, non-muscle
Roundabout, axon guidance receptor, homolog 1
(Drosophila)
Nuclear receptor subfamily 2, group F, member 1
0.230817
0.25087
0.254227
Hs.125715
Hs.367877
Hs.446537
MBNL2
MMP2
GSN
Muscleblind-like 2 (Drosophila)
MMP2
Gelsolin (amyloidosis, Finnish type)
0.255766
Hs.531581
GPR153
G protein-coupled receptor 153
p-value
<0.000001
<0.000001
<0.000001
0.000006
0.274128
0.345846
0.36839
0.423864
Hs.336046
Hs.357004
Hs.6111
Hs.111779
IL13RA2
OLFML2A
ARNT2
SPARC
0.507582
0.650845
Hs.2490
Hs.76224
CASP1
EFEMP1
0.75516
0.764736
0.830009
0.830451
0.843369
0.846476
0.867387
Hs.520937
Hs.439776
Hs.512576
Hs.415997
Hs.458420
Hs.575
Hs.89649
CSF2RA
STOM
KLRC1
COL6A1
ASMTL
ALDH3A1
EPHX1
0.899238
Hs.90786
0.926966
Hs.914
ABCC3
HLADPA1
Interleukin 13 receptor, alpha 2
Olfactomedin-like 2A
Aryl-hydrocarbon receptor nuclear translocator 2
Secreted protein, acidic, cysteine-rich (osteonectin)
Caspase 1, apoptosis-related cysteine protease (interleukin
1, beta, convertase)
EGF-containing fibulin-like extracellular matrix protein 1
Colony stimulating factor 2 receptor, alpha, low-affinity
(granulocyte-macrophage)
Stomatin
Killer cell lectin-like receptor subfamily C, member 1
Collagen, type VI, alpha 1
Acetylserotonin O-methyltransferase-like
Aldehyde dehydrogenase 3 family, memberA1
Epoxide hydrolase 1, microsomal (xenobiotic)
ATP-binding cassette, sub-family C (CFTR/MRP), member
3
Major histocompatibility complex, class II, DP alpha 1