Online only - Table 2: Chemotherapy related toxicities
All grades %
Grade III/IV %
Diarrhoea
64
14
Peripheral neuropathy
96
2
Hand foot syndrome
48
6
Neutropenia
55
8
Thrombocytopenia
26
2
Febrile neutropenia
0
Online only - Figure 3: Kaplan-Meier plot of overall survival for all enrolled
patients
Probalility of survival (%)
100
80
60
40
20
0
0
1
2
128
89
58
Number at risk
3
4
Time since registration (years)
39
26
5
6
17
8
7
Online only - Figure 5: Progression-free survival and overall survival for
patients undergoing attempt at curative resection
Probability of remaining progression free (%)
100
Subgroup B
Subgroup C
80
60
40
20
0
0
1
2
3
4
Time since registration (Years)
5
100
6
7
Subgroup B
Subgroup C
Probability of survival (%)
80
60
40
20
0
0
1
2
3
4
Time since registration (years)
5
6
7
Online only - Table 5: Characteristics of patients undergoing attempt at
resection
Subgroup B
n=10 (%)
Subgroup C
n=19 (%)
Median age
(range)
68
(38-75)
59
(51-70)
Synchronous
Presentation
80%
32%
Primary in-situ
4 (40)
4 (21)
2 (20)
1 (5)
1.8 months
16.1 months
10%
68%
3.5
(range 1-7)
27.1mm
(range 0-65)
2
(range 1-5)
20.5mm
(range 0-55)
Right Hemihepatectomy
0
3
Extended R Hepatectomy
2
2
Left hemihepatectomy
2
2
Extended L hepatecomy
2
3
2
3
1
6
1
0
Received long-course pelvic
chemoradiotherapy
Median time from diagnosis of
primary site to presentation with
metastases
Metachronous presentation
>12 months
Median number of liver lesions
at baseline for resected patients
Mean diameter of largest
resected metastasis
Type of liver resection
Segmentectomy
– 1 segment
Segmentectomy
– 2 or 3 segments
RFA
Table 6. Univariate and multivariate predictors of progression-free survival
for all enrolled patients.
Univariate Analysis
Primary disease
Local disease
No. metastases > 1
DFI > 12 months
Synch presentation
PS = 2
Hb <11
WCC >10
Subgroup B
Subgroup C
Alk phos >300
Peritoneal disease
Sig.
HR
.007
.017
.003
.010
.020
.012
.018
.022
.087
.000
.000
.015
1.68
1.98
1.82
0.57
1.61
2.37
1.78
1.77
0.65
0.38
3.51
2.16
Multivariate Analysis
95.0% CI for HR
Lower
1.15
1.13
1.23
0.37
1.08
1.21
1.11
1.09
0.39
0.24
1.78
1.16
Upper
2.43
3.47
2.70
0.88
2.42
4.63
2.87
2.88
1.07
0.60
6.93
4.01
Sig.
HR
NS
NS
NS
NS
NS
NS
NS
NS
NS
.001
.002
0.47
.460
2.98
1.89
95.0% CI for HR
Lower
.290
1.50
1.01
Upper
.740
5.94
3.55
Univariate and multivariate predictors of overall survival for all enrolled
patients.
Univariate Analysis
Primary disease
Local disease
No. metastases > 1
PS = 2
Hb <11
Platelets < 400
Bone disease
WCC >10
Subgroup B
Subgroup C
Alk Phos >300
Peritoneal disease
Sig.
HR
.023
.008
.014
.001
.025
.043
.032
.001
.189
.000
.000
.003
1.59
2.22
1.68
3.07
1.78
0.61
4.76
2.35
0.70
0.32
6.95
2.54
Multivariate Analysis
95.0% CI for HR
Lower
1.07
1.23
1.11
1.56
1.08
0.38
1.14
1.42
0.42
0.19
3.33
1.36
Upper
2.36
4.00
2.54
6.02
2.96
0.99
19.87
3.90
1.19
0.55
14.51
4.71
Sig.
HR
NS
NS
NS
NS
NS
NS
.024
.022
NS
.001
.000
.013
5.37
1.92
.409
4.50
2.24
95.0% CI for HR
Upper
1.25
1.10
.239
2.03
1.18
Upper
23.11
3.37
.699
9.96
4.24
Table 7. Univariate factors predictive of progression-free survival in
patients with isolated liver metastases (subgroups B &C).
Univariate Analysis
Largest liver met > 5cm
No. liver mets >1
CEA >200
WCC >10
Hb <11
Platelets <400
LDH >ULN
DFI >12 months
Synch presentation
Subgroup B
Age >60
Sig.
HR
.425
.471
.480
.809
.099
.765
.921
.020
.046
.063
.066
1.35
.80
.71
1.12
1.93
1.12
1.05
0.46
1.90
1.76
1.76
95.0% CI for HR
Lower
.65
.43
.28
.44
.89
.52
.41
0.23
1.01
.97
.96
Upper
2.80
1.48
1.82
2.86
4.20
2.41
2.71
0.88
3.58
3.20
3.22
Univariate and multivariate predictors of overall survival in patients with
isolated liver metastases (subgroups B &C).
Univariate Analysis
Largest liver met > 5cm
No. liver mets >1
CEA >200
WCC >10
Hb <11
Platelets < 400
LDH >ULN
DFI > 12 months
Synch presentation
Subgroup B
Age >60
Sig.
HR
.954
.987
.854
.809
.730
.112
.541
.432
.771
.012
.022
1.03
.994
.906
1.14
1.18
2.35
1.45
.751
1.11
2.37
2.31
95.0% CI for HR
Lower
.425
.493
.317
.400
.458
.818
.438
.368
.559
1.21
1.13
Upper
2.48
2.00
2.59
3.23
3.05
6.77
4.83
1.53
2.19
4.63
4.72
Multivariate Analysis
Sig.
HR
NS
NS
NS
NS
NS
NS
NS
NS
NS
.011
.013
2.45
2.54
95.0% CI for HR
Lower
1.23
1.22
Upper
4.88
5.33