Breast Cancer October 2015 This bulletin covers aspects of breast cancer, and should be of interest to multidisciplinary teams working in this area. Sections can include: Combined Modality Therapies Drug Therapy Pathology, Staging, Polymorphisms & Biomarkers Prognosis, Survival & Risk Factors Radiotherapy & Imaging Supportive Care & Symptom Management Surgery Many of the following articles are available online via the NHS Scotland Knowledge Network. Please use the links where provided and your ATHENS password. A complete list of available online journals and registration for ATHENS can be found at www.knowledge.scot.nhs.uk/ If the article you require is not available via the NHS Scotland Knowledge Network and you would like to request a print copy, please submit your request online at www.quest.scot.nhs.uk This bulletin contains a selection of material gathered from a search of the evidence base, and is not intended to be comprehensive. Professional judgment should be exercised when appraising the material. The Library takes no responsibility for the wording, content and accuracy of the information supplied, which has been extracted in good faith from reputable sources. NHSGGC is not responsible for the content of external internet sites. Compiled by: Kirsty Coltart Subject Librarian Beatson West of Scotland Cancer Centre 0141 301 7285, kirsty.coltart@ggc.scot.nhs.uk 1 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network GENERAL ESMO Clinical Practice Guidelines: Primary breast cancer. (Sep 2015) http://annonc.oxfordjournals.org/content/26/suppl_5/v8.full Francis A, Thomas J, Fallowfield L, et al. (2015). Addressing overtreatment of screen detected DCIS; the LORIS trial. European journal of cancer 51,16:2296-2303. COMBINED MODALITY THERAPIES Boughey JC, Ballman KV, Hunt KK, et al. (2015). Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance). Journal of Clinical Oncology 33,30:3386-3393. Chapman CH and Jagsi R. (2015). Postmastectomy Radiotherapy After Neoadjuvant Chemotherapy: A Review of the Evidence. Oncology (Williston Park) 29,9:657-666. Goncalves A, Pierga JY, Ferrero JM, et al. (2015). UNICANCER-PEGASE 07 study: a randomized phase III trial evaluating postoperative docetaxel-5FU regimen after neoadjuvant dose-intense chemotherapy for treatment of inflammatory breast cancer. Annals of Oncology 26,8:1692-1697. Hallam S, Govindarajulu S, Huckett B, et al. (2015). BRCA1/2 Mutation-associated Breast Cancer, Wide Local Excision and Radiotherapy or Unilateral Mastectomy: A Systematic Review. Clinical Oncology (Royal College of Radiologists) 27,9:527-535. Strnad V, Hannoun-Levi JM, Guinot JL, et al. (2015). Recommendations from GEC ESTRO Breast Cancer Working Group (I): Target definition and target delineation for accelerated or boost Partial Breast Irradiation using multicatheter interstitial brachytherapy after breast conserving closed cavity surgery. Radiotherapy & Oncology 115,3:342-348. DRUG & TARGETED THERAPY Bear HD, Tang G, Rastogi P, et al. (2015). Neoadjuvant plus adjuvant bevacizumab in early breast cancer (NSABP B-40 [NRG Oncology]): secondary outcomes of a phase 3, randomised controlled trial. Lancet Oncology 16,9:1037-1048. Farolfi A, Scarpi E, Rocca A, et al. (2015). Time to initiation of adjuvant chemotherapy in patients with rapidly proliferating early breast cancer. European journal of cancer 51,14:1874-1881. Ibrahim MF, Mazzarello S, Shorr R, et al. (2015). Should de-escalation of bone-targeting agents be standard of care for patients with bone metastases from breast cancer? A systematic review and meta-analysis. Annals of Oncology 26,11:2205-2213. Lin NU, Guo H, Yap JT, et al. (2015). Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging (TBCRC 003). Journal of Clinical Oncology 33,24:2623-2631. Seferina SC, Lobbezoo DJ, de Boer M, et al. (2015). Real-Life Use and Effectiveness of Adjuvant Trastuzumab in Early Breast Cancer Patients: A Study of the Southeast 2 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Netherlands Breast Cancer Consortium. Oncologist 20,8:856-863. Sparano JA, Zhao F, Martino S, et al. (2015). Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer. Journal of Clinical Oncology 33,21:2353-2360. Wang J, Xu B, Yuan P, et al. (2015). Capecitabine combined with docetaxel versus vinorelbine followed by capecitabine maintenance medication for first-line treatment of patients with advanced breast cancer: Phase 3 randomized trial. Cancer 121,19:34123421. Yardley DA, Bosserman LD, O'Shaughnessy JA, et al. (2015). Paclitaxel, bevacizumab, and everolimus/placebo as first-line treatment for patients with metastatic HER2-negative breast cancer: a randomized placebo-controlled phase II trial of the Sarah Cannon Research Institute. Breast Cancer Research & Treatment 154,1:89-97. PATHOLOGY, STAGING, POLYMORPHISMS, BIOMARKERS Arpino G, Milano M and De Placido S. (2015). Features of aggressive breast cancer. Breast 24,5:594-600. Criscitiello C, Esposito A, De Placido S, et al. (2015). Targeting fibroblast growth factor receptor pathway in breast cancer. Current opinion in oncology 27,6:452-456. Desmedt C, Fumagalli D, Pietri E, et al. (2015). Uncovering the genomic heterogeneity of multifocal breast cancer. Journal of Pathology 236,4:457-466. Dieci MV, Mathieu MC, Guarneri V, et al. (2015). Prognostic and predictive value of tumorinfiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials. Annals of Oncology 26,8:1698-1704. Furrer D, Sanschagrin F, Jacob S, et al. (2015). Advantages and Disadvantages of Technologies for HER2 Testing in Breast Cancer Specimens. American Journal of Clinical Pathology 144,5:686-703. Moss SM, Wale C, Smith R, et al. (2015). Effect of mammographic screening from age 40 years on breast cancer mortality in the UK Age trial at 17 years' follow-up: a randomised controlled trial. Lancet Oncology 16,9:1123-1132. Myers ER, Moorman P, Gierisch JM, et al. (2015). Benefits and Harms of Breast Cancer Screening: A Systematic Review. JAMA 314,15:1615-1634. Oeffinger KC, Fontham ET, Etzioni R, et al. (2015). Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society. JAMA 314,15:1599-1614. Tot T, Viale G, Rutgers E, et al. (2015). Optimal breast cancer pathology manifesto. European journal of cancer 51,16:2285-2288. van Nijnatten TJ, Schipper RJ, Lobbes MB, et al. (2015). The diagnostic performance of sentinel lymph node biopsy in pathologically confirmed node positive breast cancer patients after neoadjuvant systemic therapy: A systematic review and meta-analysis. European Journal of Surgical Oncology 41,10:1278-1287. Van Poznak C, Somerfield MR, Bast RC, et al. (2015). Use of Biomarkers to Guide Decisions on Systemic Therapy for Women With Metastatic Breast Cancer: American Society of 3 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Clinical Oncology Clinical Practice Guideline. Journal of Clinical Oncology 33,24:2695-2704. PROGNOSIS, SURVIVAL, RISK FACTORS Barnabei A, Strigari L, Marchetti P, et al. (2015). Predicting Ovarian Activity in Women Affected by Early Breast Cancer: A Meta-Analysis-Based Nomogram. Oncologist 20,10:1111-1118. Wagner-Johnston ND, Sloan JA, Liu H, et al. (2015). 5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial. Cancer 121,15:2537-2543. Zhou Q, Yin W, Du Y, et al. (2015). Prognostic impact of chemotherapy-induced amenorrhea on premenopausal breast cancer: a meta-analysis of the literature. Menopause 22,10:1091-1097. Zhou Y, Zhao H and Peng C. (2015). Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Annals of Epidemiology 25,9:687-697. RADIOTHERAPY AND IMAGING Canney P, Murray E, Dixon-Hughes J, et al. (2015). A Prospective Randomised Phase III Clinical Trial Testing the Role of Prophylactic Cranial Radiotherapy in Patients Treated with Trastuzumab for Metastatic Breast Cancer - Anglo Celtic VII. Clinical Oncology (Royal College of Radiologists) 27,8:460-464. Chung MJ, Lee GJ, Suh YJ, et al. (2015). Setup Error and Effectiveness of Weekly ImageGuided Radiation Therapy of TomoDirect for Early Breast Cancer. Cancer Research & Treatment 47,4:774-780. Emaus MJ, Bakker MF, Peeters PH, et al. (2015). MR Imaging as an Additional Screening Modality for the Detection of Breast Cancer in Women Aged 50-75 Years with Extremely Dense Breasts: The DENSE Trial Study Design. Radiology 277,2:527-537. Gentile MS, Usman AA, Neuschler EI, et al. (2015). Contouring Guidelines for the Axillary Lymph Nodes for the Delivery of Radiation Therapy in Breast Cancer: Evaluation of the RTOG Breast Cancer Atlas. International journal of radiation oncology, biology, physics 93,2:257-265. Jagsi R, Griffith KA, Boike TP, et al. (2015). Differences in the Acute Toxic Effects of Breast Radiotherapy by Fractionation Schedule: Comparative Analysis of Physician-Assessed and Patient-Reported Outcomes in a Large Multicenter Cohort. JAMA Oncology 1,7:918930. Liu E, Santibanez P, Puterman ML, et al. (2015). A Quantitative Analysis of the Relationship Between Radiation Therapy Use and Travel Time. International journal of radiation oncology, biology, physics 93,3:710-718. Meattini I, Saieva C, Marrazzo L, et al. (2015). Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial. 4 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Breast Cancer Research & Treatment 153,3:539-547. Ng SP, David S, Alamgeer M, et al. (2015). Impact of Pretreatment Combined (18)FFluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging on Radiation Therapy Treatment Decisions in Locally Advanced Breast Cancer. International journal of radiation oncology, biology, physics 93,1:111-117. Pignol JP, Caudrelier JM, Crook J, et al. (2015). Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers. International journal of radiation oncology, biology, physics 93,3:614-621. Poortmans PM, Collette S, Kirkove C, et al. (2015). Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer. New England Journal of Medicine 373,4:317327 Shaitelman SF, Schlembach PJ, Arzu I, et al. (2015). Acute and Short-term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation: A Randomized Clinical Trial. JAMA Oncology 1,7:931-941. Taylor CW and Kirby AM. (2015). Cardiac Side-effects From Breast Cancer Radiotherapy. Clinical Oncology (Royal College of Radiologists) 27,11:621-629. van Roozendaal LM, Schipper RJ, Smit LH, et al. (2015). Three-Dimensional Breast Radiotherapy and the Elective Radiation Dose at the Sentinel Lymph Node Site in Breast Cancer. Annals of Surgical Oncology 22,12:3824-3830. Whelan TJ, Olivotto IA, Parulekar WR, et al. (2015). Regional Nodal Irradiation in Early-Stage Breast Cancer. New England Journal of Medicine 373,4:307-316. Wong K, Delaney GP and Barton MB. (2015). Estimation of the optimal number of radiotherapy fractions for breast cancer: A review of the evidence. Radiotherapy & Oncology 116,2:174-178. Zhou ZR, Mei X, Chen XX, et al. (2015). Systematic review and meta-analysis comparing hypofractionated with conventional fraction radiotherapy in treatment of early breast cancer. Surgical oncology 24,3:200-211. SUPPORTIVE CARE AND SYMPTOM MANAGEMENT Arslan M and Ozdemir L. (2015). Oral Intake of Ginger for Chemotherapy-Induced Nausea and Vomiting Among Women With Breast Cancer. Clinical journal of oncology nursing 19,5:E92-7. Bartula I and Sherman KA. (2015). The Female Sexual Functioning Index (FSFI): evaluation of acceptability, reliability, and validity in women with breast cancer. Supportive Care in Cancer 23,9:2633-2641. Bradley Palmer J, Lane D, Mayo D, et al. (2015). Effects of Music Therapy on Anesthesia Requirements and Anxiety in Women Undergoing Ambulatory Breast Surgery for Cancer Diagnosis and Treatment: A Randomized Controlled Trial. Journal of Clinical Oncology 33,28:3162-3168. Choi E, Nahm FS and Lee PB. (2015). Sympathetic Block as a New Treatment for Lymphedema. Pain Physician 18,4:365-372. 5 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Das N, Baumgartner RN, Riley EC, et al. (2015). Treatment-related risk factors for arm lymphedema among long-term breast cancer survivors. Journal of Cancer Survivorship 9,3:422-430. de Boer AG, Taskila TK, Tamminga SJ, et al. (2015). Interventions to enhance return-towork for cancer patients. Cochrane Database of Systematic Reviews 9,007569. Derry HM, Jaremka LM, Bennett JM, et al. (2015). Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psycho-oncology 24,8:958-966. Divers J and O'Shaughnessy J. (2015). Stomatitis Associated With Use of mTOR Inhibitors: Implications for Patients With Invasive Breast Cancer. Clinical journal of oncology nursing 19,4:468-474. Do T, Medhekar R, Bhat R, et al. (2015). The risk of febrile neutropenia and need for G-CSF primary prophylaxis with the docetaxel and cyclophosphamide regimen in early-stage breast cancer patients: a meta-analysis. Breast Cancer Research & Treatment 153,3:591597. Dodds SE, Pace TW, Bell ML, et al. (2015). Feasibility of Cognitively-Based Compassion Training (CBCT) for breast cancer survivors: a randomized, wait list controlled pilot study. Supportive Care in Cancer 23,12:3599-3608. Dow J and Kennedy Sheldon L. (2015). Breast Cancer Survivors and Sexuality: A Review of the Literature Concerning Sexual Functioning, Assessment Tools, and Evidence-Based Interventions. Clinical journal of oncology nursing 19,4:456-461. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Coleman R, Powles T, et al. (2015). Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials. Lancet 386,10001:1353-1361. Ercoli LM, Petersen L, Hunter AM, et al. (2015). Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial. Psycho-oncology 24,11:1360-1367. Eyigor S, Cinar E, Caramat I, et al. (2015). Factors influencing response to lymphedema treatment in patients with breast cancer-related lymphedema. Supportive Care in Cancer 23,9:2705-2710. Ezzo J, Manheimer E, McNeely ML, et al. (2015). Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database of Systematic Reviews 5,003475. Fenlon DR, Khambhaita P and Hunter MS. (2015). Helping Patients to Help Themselves after Breast Cancer Treatment. Clinical Oncology (Royal College of Radiologists) 27,11:640-646. Freeman LW, White R, Ratcliff CG, et al. (2015). A randomized trial comparing live and telemedicine deliveries of an imagery-based behavioral intervention for breast cancer survivors: reducing symptoms and barriers to care. Psycho-oncology 24,8:910-918. Freysteinson WM, Deutsch AS, Davin K, et al. (2015). The Mirror Program: Preparing Women for the Postoperative Mastectomy Mirror-Viewing Experience. Nursing forum 50,4:252-257. Gudenkauf LM, Antoni MH, Stagl JM, et al. (2015). Brief cognitive-behavioral and relaxation training interventions for breast cancer: A randomized controlled trial. Journal of Consulting & Clinical Psychology 83,4:677-688. 6 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Harris LN, Cleary EH and Stanton AL. (2015). Project connect online: user and visitor experiences of an Internet-based intervention for women with breast cancer. Psychooncology 24,9:1145-1151. Hernandez Torres C, Mazzarello S, Ng T, et al. (2015). Defining optimal control of chemotherapy-induced nausea and vomiting-based on patients' experience. Supportive Care in Cancer 23,11:3341-3359. Hofheinz RD, Gencer D, Schulz H, et al. (2015). Mapisal Versus Urea Cream as Prophylaxis for Capecitabine-Associated Hand-Foot Syndrome: A Randomized Phase III Trial of the AIO Quality of Life Working Group. Journal of Clinical Oncology 33,22:2444-2449. Huang HP, Wen FH, Tsai JC, et al. (2015). Adherence to prescribed exercise time and intensity declines as the exercise program proceeds: findings from women under treatment for breast cancer. Supportive Care in Cancer 23,7:2061-2071. Jassim GA, Whitford DL, Hickey A, et al. (2015). Psychological interventions for women with non-metastatic breast cancer. Cochrane Database of Systematic Reviews 5,008729. Le Rhun E, Delbeuck X, Lefeuvre-Plesse C, et al. (2015). A phase III randomized multicenter trial evaluating cognition in post-menopausal breast cancer patients receiving adjuvant hormonotherapy. Breast Cancer Research & Treatment 152,3:569-580. Lopez C, Charles C, Rouby P, et al. (2015). Relations between arthralgia and fear of recurrence: results of a cross-sectional study of breast cancer patients treated with adjuvant aromatase inhibitors therapy. Supportive Care in Cancer 23,12:3581-3588. Maass SW, Roorda C, Berendsen AJ, et al. (2015). The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: A systematic review. Maturitas 82,1:100-108. Manne SL, Siegel S, Heckman CJ, et al. (2015). Psychological distress as a mediator of the association between disease severity and occupational functioning among employed spouses of women recently diagnosed with breast cancer. Psycho-oncology 24,11:15601568. Mao JJ, Bowman MA, Xie SX, et al. (2015). Electroacupuncture Versus Gabapentin for Hot Flashes Among Breast Cancer Survivors: A Randomized Placebo-Controlled Trial. Journal of Clinical Oncology 33,31:3615-3620. Mejdahl MK, Mertz BG, Bidstrup PE, et al. (2015). Preoperative Distress Predicts Persistent Pain After Breast Cancer Treatment: A Prospective Cohort Study. Journal of the National Comprehensive Cancer Network 13,8:995-1003. Morean DF, O'Dwyer L and Cherney LR. (2015). Therapies for Cognitive Deficits Associated With Chemotherapy for Breast Cancer: A Systematic Review of Objective Outcomes. Archives of Physical Medicine & Rehabilitation 96,10:1880-1897. Okuyama S, Jones W, Ricklefs C, et al. (2015). Psychosocial telephone interventions for patients with cancer and survivors: a systematic review. Psycho-oncology 24,8:857-870. Phillips SM, Dodd KW, Steeves J, et al. (2015). Physical activity and sedentary behavior in breast cancer survivors: New insight into activity patterns and potential intervention targets. Gynecologic oncology 138,2:398-404. Rock CL, Flatt SW, Byers TE, et al. (2015). Results of the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial: A Behavioral Weight Loss Intervention in Overweight or Obese Breast Cancer Survivors. Journal of Clinical Oncology 33,28:3169-3176. 7 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network Ronn R and Holzer H. (2015). Breast cancer and fertility: an update. Current Opinion in Supportive & Palliative Care 9,3:285-293. Schmidt A, Kowalski C, Pfaff H, et al. (2015). The Influence of Health Literacy on Information Needs Among Women Newly Diagnosed With Breast Cancer, With Special Reference to Employment Status. Journal of health communication 20,10:1177-1184. Shaw LK, Sherman K and Fitness J. (2015). Dating concerns among women with breast cancer or with genetic breast cancer susceptibility: a review and meta-synthesis. Health Psychology Review 9,4:491-505. Shen MJ, Dyson RC, D'Agostino TA, et al. (2015). Cancer-related internet information communication between oncologists and patients with breast cancer: a qualitative study. Psycho-oncology 24,11:1439-1447. Swisher AK, Abraham J, Bonner D, et al. (2015). Exercise and dietary advice intervention for survivors of triple-negative breast cancer: effects on body fat, physical function, quality of life, and adipokine profile. Supportive Care in Cancer 23,10:2995-3003. Teo I, Novy DM, Chang DW, et al. (2015). Examining pain, body image, and depressive symptoms in patients with lymphedema secondary to breast cancer. Psycho-oncology 24,11:1377-1383. Villarreal-Garza C, Martinez-Cannon BA, Platas A, et al. (2015). Specialized programs to support young women with breast cancer. Current Opinion in Supportive & Palliative Care 9,3:308-316. Wang LY, Pierdomenico A, Lefkowitz A, et al. (2015). Female Sexual Health Training for Oncology Providers: New Applications. Sexual Medicine 3,3:189-197. Wiseman KP, Bishop DL, Shen Q, et al. (2015). Survivorship care plans and time since diagnosis: factors that contribute to who breast cancer survivors see for the majority of their care. Supportive Care in Cancer 23,9:2669-2676. Wyatt G, Sikorskii A, Tesnjak I, et al. (2015). Chemotherapy interruptions in relation to symptom severity in advanced breast cancer. Supportive Care in Cancer 23,11:3183-3191. Younus J, Lock M, Vujovic O, et al. (2015). A case-control, mono-center, open-label, pilot study to evaluate the feasibility of therapeutic touch in preventing radiation dermatitis in women with breast cancer receiving adjuvant radiation therapy. Complementary therapies in medicine 23,4:612-616. Zhou ES, Falk SJ and Bober SL. (2015). Managing premature menopause and sexual dysfunction. Current Opinion in Supportive & Palliative Care 9,3:294-300. SURGERY Basu NN, Ross GL, Evans DG, et al. (2015). The Manchester guidelines for contralateral risk-reducing mastectomy. World Journal of Surgical Oncology 13,237. Chester R, Bokinni O, Ahmed I, et al. (2015). UK national survey of management of breast lobular carcinoma in situ. Annals of the Royal College of Surgeons of England 97,8:574-577. Criscitiello C, Giuliano M, Curigliano G, et al. (2015). Surgery of the primary tumor in de novo metastatic breast cancer: To do or not to do? European Journal of Surgical Oncology 8 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network 41,10:1288-1292. Jerome-D'Emilia B, Suplee PD, Boiler JL, et al. (2015). A Woman's Decision to Choose Bilateral Mastectomy. Cancer nursing 38,6:426-435. Liu Y, Wang Y, Zhou L, et al. (2015). Prognostic effect of menstrual cycle on timing of surgery in premenopausal breast cancer patients. American Journal of Surgery 210,3:506511. Mimouni M, Lecuru F, Rouzier R, et al. (2015). Reexcision for positive margins in breast cancer: A predictive score of residual disease. Surgical oncology 24,3:129-135. Moossdorff M, Vugts G, Maaskant-Braat AJ, et al. (2015). Contralateral lymph node recurrence in breast cancer: Regional event rather than distant metastatic disease. A systematic review of the literature. European Journal of Surgical Oncology 41,9:1128-1136. O'Brien JA, Ho A, Wright GP, et al. (2015). Breast-Conserving Surgery in Bilateral Breast Cancer. Annals of Surgical Oncology 22,10:3389-3396. Sagara Y, Mallory MA, Wong S, et al. (2015). Survival Benefit of Breast Surgery for LowGrade Ductal Carcinoma In Situ: A Population-Based Cohort Study. JAMA Surgery 150,8:739-745. Please note that the journal articles you are accessing are subject to the terms and conditions imposed by the publisher, so there will be a limit on the number of articles an individual may download or print from a single issue of a journal. You can consult your local NHSGGC library with any queries. If you have any questions regarding this or any other library services please contact Library staff – contact details are at the beginning of the bulletin. Sources used for this bulletin: OVID MEDLINE, SIGN, NICE, Healthcare Improvement Scotland 9 Breast Cancer, October 2015 Kirsty Coltart, Subject Librarian, NHSGGC Library Network