Annotations of proteins belonging to the significant networks identified by IPA and showed in figure 4.
Symbols corresponding to the identified proteins are shown in bold.
Network (CNS area)
I (Brain)
II (Brain)
III (Cerebellum)
Annotations
ACO2 =aconitase 2, mitochondrial; APP= amyloid beta (A4) precursor protein; ARHGDIA= Rho GDP dissociation inhibitor (GDI) alpha; CKB = creatine kinase, brain; DBN1 = drebrin 1; DNM1 = dynamin 1; DPYSL2 = dihydropyrimidinase-like 2; ERK= p42/p44 Map Kinase; GHRL= ghrelin/obestatin prepropeptide; GLUD1 = glutamate dehydrogenase; Gpd= alpha-glycerophoshate dehydrogenase; GPD2 = glycerol-3-phosphate dehydrogenase 2
(mitochondrial); HSP90B1 = heat shock protein 90kDa beta (Grp94), member 1; IKBKG= inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; LDHB = lactate dehydrogenase B; MAP3K3= mitogen-activated protein kinase kinase kinase 3; MTTP= microsomal triglyceride transfer protein; NEFM = neurofilament, medium polypeptide; NR6A1= nuclear receptor subfamily 6, group A, member 1; PI4KA= phosphatidylinositol 4-kinase, catalytic, alpha; PITPNA = phosphatidylinositol transfer protein, alpha; Pkc(s)= Protein kinase c; PPARA= peroxisome proliferator activated receptor alpha; PPARGC1A= peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PTGS1= prostaglandin-endoperoxide synthase 1; SNAP25 = synaptosomal-associated protein, 25kDa; SNCA : synuclein, alpha (non
A4 component of amyloid precursor); TNF= tumor necrosis factor (TNF superfamily, member 2); TPI1 = triosephosphate isomerase 1; TPM1 = tropomyosin 1 (alpha).
ATP6V1A = ATPase, H
+
transporting, lysosomal 70kDa, V1 subunitA; ATP6V1B2 = ATPase, H+ transporting, lysosomal
56/58kDa, V1 subunit B2; CREM= cAMP responsive element modulator; ENO1 = enolase 1, (alpha); EPO= erythropoietin;
FANCA= Fanconi anemia, complementation group A; GRB2= growth factor receptor; HBB(includeEG:3043) = haemoglobin beta; IDH3A = isocitrate dehydrogenase 3 (NAD+) alpha; IDH3B= isocitrate dehydrogenase 3 (NAD+) beta;
IDH3G= isocitrate dehydrogenase 3 (NAD+) gamma; IL4= interleukin 4; IL12B= interleukin 12B; ITGAL= integrin, alpha
L; ITGA4= integrin, alpha 4; ITGB2= integrin, beta 2; MYC= v-myc myelocytomatosis viral oncogene homolog (avian);
PPARGC1A= peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PRKCE= protein kinase C, epsilon;
PRNP= prion protein; PTGS2= prostaglandin-endoperoxide synthase 2; RNF128= ring finger protein; SMARCC1=
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; ST3GAL4= ST3 betagalactoside alpha-2,3-sialyltransferase 4; TNFRSF1B= tumor necrosis factor receptor superfamily, member 1B; UQCRC1 = ubiquinol-cytochrome c reductase core protein I;; UQCRH= ubiquinol-cytochrome c reductase hinge protein; VWF= von
Willebrand factor; WDR1 = WD repeat domain 1; XBP1= X-box binding protein 1
ACTB= actin beta; ARHGDIA = Rho GDP dissociation inhibitor (GDI) alpha; CA2 = carbonic anhydrase II; CCT5 = chaperonin containing TCP1, subunit 5 (epsilon); CKB = creatine kinase, brain;CLIC4= chloride intracellular channel 4;
DPYSL2 = dihydropyrimidinase-like 2; DYNLL1= dynein, light chain, LC8-type 1; ENO1 = enolase 1, (alpha); FBXO2= Fbox protein 2; GLO1 = glyoxalase I; GLUD1 = glutamate dehydrogenase 1; HGF= hepatocyte growth factor (hepapoietin A; scatter factor); IDH3A = isocitrate dehydrogenase 3 (NAD+) alpha; IDH3G= isocitrate dehydrogenase 3 (NAD+) gamma;
IKBKE= inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon; LDHB = lactate dehydrogenase B;
MT3= metallothionein 3; MYC= v-myc myelocytomatosis viral oncogene homolog (avian); NGLY1= N-glycanase 1;
PGAM1 = phosphoglycerate mutase 1 (brain); PPP1CC= protein phosphatase 1, catalytic subunit, gamma isoform; RHOA= ras homolog gene family, member A; Rock= Rho kinase; ROCK2= Rho associated, coiled-coil containing protein kinase 2;
SEDLP= trafficking protein particle complex 2 pseudogene 1; SEMA3A= semaphorin 3A; SSBP2= single-stranded DNA binding protein 2; TNF= tumor necrosis factor (TNF superfamily, member 2); TOMM34= translocase of outer mitochondrial membrane 34; UBB= ubiquitin B; UCHL1 = ubiquitin carboxyl-terminal esterase L1; VCP = valosincontaining protein; WIPF1= WAS/WASL interacting protein family, member 1.

hippocampus, Martin B.
ref. 9 f f

Protein classification in the loci identified by the three-way Venn diagram analysis . The six loci containing the proteins identified in this study are listed in the alphabetical key from figure S1. NCBI accession numbers and the protein names are shown. b
(group 2 only) c
(group 3 only) d
(common to groups 1 and 2) e
(common to groups 2 and 3)
29144967
(WD repeat-containing protein 1)
6755863
(Heat shock protein 90 kDa beta member 1)
124504386
(Neurofilament medium polypeptide)
165932331
(Glyoxalase I)
157951596
(Carbonic anhydrase 2)
37359776
(CCT-epsilon)
6678047
(Alpha-synuclein)
b
4760590
(Hemoglobin subunit beta-1)
a
226958349
(Triosephosphate isomerase)
b
56789289
(L-lactate dehydrogenase B chain)
6680027
(Glutamate dehydrogenase 1, mitochondrial)
31982030
(Rho GDP-dissociation inhibitor
1)
487851
(Dynamin-1)
6679337
(Phosphatidylinositol transfer protein alpha isoform)
148670553
(Valosin containing protein)
114326546
(Phosphoglycerate mutase )
256000796
(Tropomyosin alpha-1 chain)
3156073
(V-type proton ATPase catalytic subunit A)
a
148693871
(Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial)
6755588
(Synaptosomal-associated protein 25)
b
60391212
(Aconitate hydratase, mitochondrial)
a
51338706
(V-type proton ATPase subunit B, brain isoform)
123232244
(Glycerol-3-phosphate dehydrogenase, mitochondrial)
14548301
(Cytochrome b-c1 complex subunit 1, mitochondrial)
19909851
(Drebrin)
187956864
(Oxoglutarate Dehydrogenase like protein ) a Difference in expression level in agreement with that observed by Martin et al . (ref. 9) b Difference in expression level in disagreement with that observed by Martin et al.
. (ref. 9) f
(common to groups 1 and 3)
188219614
(Ubiquitin carboxyl-terminal hydrolase isozyme L1) g
(common to groups 1, 2, and 3)
40254595
(Dihydropyrimidinase-related protein 2)
a
13637776
(Alpha-enolase)
10946574
(Creatine kinase B-type)
b